keyword
https://read.qxmd.com/read/38534715/equivalence-trial-of-the-non-bismuth-10-day-concomitant-and-14-day-hybrid-therapies-for-helicobacter-pylori-eradication-in-high-clarithromycin-resistance-areas
#21
JOURNAL ARTICLE
Sotirios D Georgopoulos, Elias Xirouchakis, Christos Liatsos, Pericles Apostolopoulos, Panagiotis Kasapidis, Beatriz Martinez-Gonzalez, Fotini Laoudi, Maria Stoupaki, Georgios Axiaris, Dionysios Sgouras, Andreas Mentis, Spyridon Michopoulos
Background and aim : We conducted an equivalence trial of quadruple non-bismuth "concomitant" and "hybrid" regimens for H. pylori eradication in a high clarithromycin resistance area. Methods : There were 321 treatment-naïve H. pylori -positive individuals in this multicenter clinical trial randomized to either the hybrid (esomeprazole 40 mg/bid, amoxicillin 1 g/bid for 7 days, then 7 days esomeprazole 40 mg/bid, amoxicillin 1 g/bid, clarithromycin 500 mg/bid, and metronidazole 500 mg/bid) or the concomitant regimen (all medications given concurrently bid for 10 days)...
March 20, 2024: Antibiotics
https://read.qxmd.com/read/38534712/multiple-drug-resistant-streptococcus-strains-an-actual-problem-in-pig-farms-in-western-romania
#22
JOURNAL ARTICLE
Luminita Costinar, Corina Badea, Adela Marcu, Corina Pascu, Viorel Herman
Streptococci are a type of bacteria that can cause severe illnesses in humans and animals. Some typical species like S. suis , or atypical species like S. porcinus and, S. dysgalactiae subsp. dysgalactiae , can cause infections like septicemia, meningitis, endocarditis, arthritis, and septic shock. S. suis is considered a newly emerging zoonotic pathogen. Although human streptococcal infection outbreaks are rare, it is appropriate to review the main streptococcal species isolated in pig farms in western Romania, due to the high degree of antibiotic resistance among most isolates commonly used in human treatment...
March 19, 2024: Antibiotics
https://read.qxmd.com/read/38534709/effect-of-inappropriate-treatment-in-hospitalized-patients-with-pyelonephritis-treated-with-cefuroxime-a-cohort-study
#23
JOURNAL ARTICLE
Jorge Alberto Cortés, Claudia Rocío Sierra, Ricardo Sánchez
The aim of this study was to evaluate the effect of inappropriate therapy in adult patients with community-acquired pyelonephritis caused by Escherichia coli receiving empirical treatment with cefuroxime during hospital stay and readmission. A retrospective cohort study was performed. Inappropriate treatment was considered treatment for a nonsusceptible isolate according to the results of the urine culture. Adjustment for confounding factors was performed with propensity score-derived inverse probability of treatment weighting...
March 19, 2024: Antibiotics
https://read.qxmd.com/read/38534708/strategies-for-preventing-and-treating-oral-mucosal-infections-associated-with-removable-dentures-a-scoping-review
#24
REVIEW
Adriana Barbosa Ribeiro, Pillar Gonçalves Pizziolo, Lorena Mosconi Clemente, Helena Cristina Aguiar, Beatriz de Camargo Poker, Arthur Augusto Martins E Silva, Laís Ranieri Makrakis, Marco Aurelio Fifolato, Giulia Cristina Souza, Viviane de Cássia Oliveira, Evandro Watanabe, Cláudia Helena Lovato da Silva
Oral infections occur due to contact between biofilm rich in Candida albicans formed on the inner surface of complete dentures and the mucosa. This study investigated historical advances in the prevention and treatment of oral mucosal infection and identified gaps in the literature. Bibliographic research was conducted, looking at PubMed, Embase, Web of Science, and Scopus, where 935 articles were found. After removing duplicates and excluding articles by reading the title and abstract, 131 articles were selected for full reading and 104 articles were included...
March 18, 2024: Antibiotics
https://read.qxmd.com/read/38534707/when-to-stop-antibiotics-in-the-critically-ill
#25
REVIEW
Nathan D Nielsen, James T Dean, Elizabeth A Shald, Andrew Conway Morris, Pedro Povoa, Jeroen Schouten, Nicholas Parchim
Over the past century, antibiotic usage has skyrocketed in the treatment of critically ill patients. There have been increasing calls to establish guidelines for appropriate treatment and durations of antibiosis. Antibiotic treatment, even when appropriately tailored to the patient and infection, is not without cost. Short term risks-hepatic/renal dysfunction, intermediate effects-concomitant superinfections, and long-term risks-potentiating antimicrobial resistance (AMR), are all possible consequences of antimicrobial administration...
March 18, 2024: Antibiotics
https://read.qxmd.com/read/38534705/scientific-rationale-and-clinical-basis-for-clindamycin-use-in-the-treatment-of-dermatologic-disease
#26
REVIEW
Maria K Armillei, Ivan B Lomakin, James Q Del Rosso, Ayman Grada, Christopher G Bunick
Clindamycin is a highly effective antibiotic of the lincosamide class. It has been widely used for decades to treat a range of skin and soft tissue infections in dermatology and medicine. Clindamycin is commonly prescribed for acne vulgaris, with current practice standards utilizing fixed-combination topicals containing clindamycin that prevent Cutibacterium acnes growth and reduce inflammation associated with acne lesion formation. Certain clinical presentations of folliculitis, rosacea, staphylococcal infections, and hidradenitis suppurativa are also responsive to clindamycin, demonstrating its suitability and versatility as a treatment option...
March 17, 2024: Antibiotics
https://read.qxmd.com/read/38534704/a-single-dose-of-piperacillin-plus-tazobactam-gel-as-an-adjunct-to-professional-mechanical-plaque-removal-pmpr-in-patients-with-peri-implant-mucositis-a-6-month-double-blind-randomized-clinical-trial
#27
JOURNAL ARTICLE
Ioana Ilyes, Marius Boariu, Darian Rusu, Vincenzo Iorio-Siciliano, Octavia Vela, Simina Boia, Georgios Kardaras, Petra Șurlin, Horia Calniceanu, Holger Jentsch, Alexandru Lodin, Stefan-Ioan Stratul
OBJECTIVES: This randomized, placebo-controlled, double-masked clinical trial aimed to evaluate the clinical and microbiological efficacy of professional mechanical plaque removal (PMPR) with or without adjunctive application of piperacillin plus tazobactam gel in the treatment of peri-implant mucositis (PiM) for up to 6 months. MATERIALS AND METHODS: The study included 31 patients with peri-implant mucositis (bleeding on probing (BoP) > 1 at at least one site at baseline, absence of peri-implant bone loss compared with a previous radiograph)...
March 17, 2024: Antibiotics
https://read.qxmd.com/read/38534703/rethinking-hidradenitis-suppurativa-management-insights-into-bacterial-interactions-and-treatment-evolution
#28
REVIEW
Faith D Huynh, Giovanni Damiani, Christopher G Bunick
Hidradenitis suppurativa (HS), or acne inversa, is a chronic inflammatory dermatological condition characterized by painful and recurrent nodules and purulent abscesses. HS can have a devastating impact on the quality of life of patients. This condition is commonly localized to the axilla, groin, perineal, and inframammary regions, and can develop fistulas and sinus tracts over time. Its pathogenesis remains elusive and is best characterized at the moment as multi-factorial. Additionally, questions remain about the role of cutaneous dysbiosis as a primary HS trigger or as a secondary perturbation due to HS inflammation...
March 17, 2024: Antibiotics
https://read.qxmd.com/read/38534701/identification-and-clinical-characteristics-of-community-acquired-acinetobacter-baumannii-in-patients-hospitalized-for-moderate-or-severe-covid-19-in-peru
#29
JOURNAL ARTICLE
Wilmer Silva-Caso, Giancarlo Pérez-Lazo, Miguel Angel Aguilar-Luis, Adriana Morales-Moreno, José Ballena-López, Fernando Soto-Febres, Johanna Martins-Luna, Luis J Del Valle, Sungmin Kym, Deysi Aguilar-Luis, Dayana Denegri-Hinostroza, Juana Del Valle-Mendoza
Acinetobacter baumannii has been described as a cause of serious community-acquired infections in tropical countries. Currently, its implications when simultaneously identified with other pathogens are not yet adequately understood. A descriptive study was conducted on hospitalized patients with a diagnosis of moderate/severe SARS-CoV-2-induced pneumonia confirmed via real-time RT-PCR. Patients aged > 18 years who were admitted to a specialized COVID-19 treatment center in Peru were selected for enrollment...
March 16, 2024: Antibiotics
https://read.qxmd.com/read/38534699/generation-and-characterization-of-stable-small-colony-variants-of-usa300-staphylococcus-aureus-in-raw-264-7-murine-macrophages
#30
JOURNAL ARTICLE
Dalida Bivona, Carmelo Bonomo, Lorenzo Colombini, Paolo G Bonacci, Grete F Privitera, Giuseppe Caruso, Filippo Caraci, Francesco Santoro, Nicolò Musso, Dafne Bongiorno, Francesco Iannelli, Stefania Stefani
Intracellular survival and immune evasion are typical features of staphylococcal infections. USA300 is a major clone of methicillin-resistant S. aureus (MRSA), a community- and hospital-acquired pathogen capable of disseminating throughout the body and evading the immune system. Carnosine is an endogenous dipeptide characterized by antioxidant and anti-inflammatory properties acting on the peripheral (macrophages) and tissue-resident (microglia) immune system. In this work, RAW 264.7 murine macrophages were infected with the USA300 ATCC BAA-1556 S...
March 16, 2024: Antibiotics
https://read.qxmd.com/read/38534698/biofilm-development-by-mycobacterium-avium-complex-clinical-isolates-effect-of-clarithromycin-in-ultrastructure
#31
JOURNAL ARTICLE
Arij Akir, Abrar Senhaji-Kacha, Maria Carmen Muñoz-Egea, Jaime Esteban, John Jairo Aguilera-Correa
BACKGROUND: The Mycobacterium avium complex includes the commonest non-tuberculous mycobacteria associated with human infections. These infections have been associated with the production of biofilms in many cases, but there are only a few studies about biofilms produced by the species included in this group. METHODS: Three collection strains ( M. avium ATCC25291, M. intracellulare ATCC13950, and M. chimaera DSM756), three clinically significant strains (647, 657, and 655), and three clinically non-significant ones (717, 505, and 575) of each species were included...
March 16, 2024: Antibiotics
https://read.qxmd.com/read/38534697/post-covid-19-pandemic-rebound-of-macrolide-resistant-mycoplasma-pneumoniae-infection-a-descriptive-study
#32
JOURNAL ARTICLE
Fan-Fan Xing, Kelvin Hei-Yeung Chiu, Chao-Wen Deng, Hai-Yan Ye, Lin-Lin Sun, Yong-Xian Su, Hui-Jun Cai, Simon Kam-Fai Lo, Lei Rong, Jian-Liang Chen, Vincent Chi-Chung Cheng, David Christopher Lung, Siddharth Sridhar, Jasper Fuk-Woo Chan, Ivan Fan-Ngai Hung, Kwok-Yung Yuen
The rebound characteristics of respiratory infections after lifting pandemic control measures were uncertain. From January to November 2023, patients presenting at a teaching hospital were tested for common respiratory viruses and Mycoplasma pneumoniae using a combination of antigen, nucleic acid amplification, and targeted next-generation sequencing (tNGS) tests. The number and rate of positive tests per month, clinical and microbiological characteristics were analyzed. A rapid rebound of SARS-CoV-2 was followed by a slower rebound of M...
March 15, 2024: Antibiotics
https://read.qxmd.com/read/38534696/current-therapeutic-approaches-for-multidrug-resistant-and-extensively-drug-resistant-acinetobacter-baumannii-infections
#33
REVIEW
Petros Rafailidis, Periklis Panagopoulos, Christos Koutserimpas, George Samonis
The treatment of Acinetobacter baumannii infections remains a challenge for physicians worldwide in the 21st century. The bacterium possesses a multitude of mechanisms to escape the human immune system. The consequences of A. baumannii infections on morbidity and mortality, as well on financial resources, remain dire. Furthermore, A. baumannii superinfections have also occurred during the COVID-19 pandemic. While prevention is important, the antibiotic armamentarium remains the most essential factor for the treatment of these infections...
March 15, 2024: Antibiotics
https://read.qxmd.com/read/38534695/role-of-%C3%AE-lactamase-inhibitors-as-potentiators-in-antimicrobial-chemotherapy-targeting-gram-negative-bacteria
#34
REVIEW
Song Zhang, Xinyu Liao, Tian Ding, Juhee Ahn
Since the discovery of penicillin, β-lactam antibiotics have commonly been used to treat bacterial infections. Unfortunately, at the same time, pathogens can develop resistance to β-lactam antibiotics such as penicillins, cephalosporins, monobactams, and carbapenems by producing β-lactamases. Therefore, a combination of β-lactam antibiotics with β-lactamase inhibitors has been a promising approach to controlling β-lactam-resistant bacteria. The discovery of novel β-lactamase inhibitors (BLIs) is essential for effectively treating antibiotic-resistant bacterial infections...
March 15, 2024: Antibiotics
https://read.qxmd.com/read/38534690/chestnut-honey-is-effective-against-mixed-biofilms-at-different-stages-of-maturity
#35
JOURNAL ARTICLE
Regina Koloh, Viktória L Balázs, Lilla Nagy-Radványi, Béla Kocsis, Erika Beáta Kerekes, Marianna Kocsis, Ágnes Farkas
The irresponsible overuse of antibiotics has increased the occurrence of resistant bacterial strains, which represents one of the biggest patient safety risks today. Due to antibiotic resistance and biofilm formation in bacteria, it is becoming increasingly difficult to suppress the bacterial strains responsible for various chronic infections. Honey was proven to inhibit bacterial growth and biofilm development, offering an alternative solution in the treatment of resistant infections and chronic wounds. Our studies included chestnut honey, valued for its high antibacterial activity, and the bacteria Pseudomonas aeruginosa , methicillin-resistant Staphylococcus aureus , and S...
March 13, 2024: Antibiotics
https://read.qxmd.com/read/38534686/antimicrobial-properties-of-colostrum-and-milk
#36
REVIEW
Furkan Eker, Emir Akdaşçi, Hatice Duman, Yalçın Mert Yalçıntaş, Ahmet Alperen Canbolat, Arda Erkan Kalkan, Sercan Karav, Dunja Šamec
The growing number of antibiotic resistance genes is putting a strain on the ecosystem and harming human health. In addition, consumers have developed a cautious attitude towards chemical preservatives. Colostrum and milk are excellent sources of antibacterial components that help to strengthen the immunity of the offspring and accelerate the maturation of the immune system. It is possible to study these important defenses of milk and colostrum, such as lactoferrin, lysozyme, immunoglobulins, oligosaccharides, etc...
March 11, 2024: Antibiotics
https://read.qxmd.com/read/38534685/an-overview-of-antibiotic-therapy-for-early-and-late-onset-neonatal-sepsis-current-strategies-and-future-prospects
#37
REVIEW
Giovanni Boscarino, Rossana Romano, Carlotta Iotti, Francesca Tegoni, Serafina Perrone, Susanna Esposito
Neonatal sepsis is a clinical syndrome mainly associated with a bacterial infection leading to severe clinical manifestations that could be associated with fatal sequalae. According to the time of onset, neonatal sepsis is categorized as early- (EOS) or late-onset sepsis (LOS). Despite blood culture being the gold standard for diagnosis, it has several limitations, and early diagnosis is not immediate. Consequently, most infants who start empirical antimicrobial therapy do not have an underlying infection. Despite stewardship programs partially reduced this negative trend, in neonatology, antibiotic overuse still persists, and it is associated with several relevant problems, the first of which is the increase in antimicrobial resistance (AMR)...
March 10, 2024: Antibiotics
https://read.qxmd.com/read/38534678/experience-with-pcr-testing-for-enteric-bacteria-and-viruses-of-emergency-department-patients-with-acute-gastroenteritis-are-there-implications-for-the-early-treatment-of-clostridioides-difficile-infection
#38
JOURNAL ARTICLE
Andreas Iffland, Maria Zechel, Jan-Christoph Lewejohann, Birgit Edel, Stefan Hagel, Michael Hartmann, Bettina Löffler, Jürgen Rödel
Early identification of acute gastroenteritis (AGE) pathogens via PCR may improve the management of patients presenting to the emergency department (ED). In this study, we evaluated the implementation of a testing algorithm for ED patients with AGE using the BD MAX automated PCR system. Data from 133 patients were analyzed. A total of 56 patients (42%) tested positive via PCR for at least one bacterial or viral pathogen. The median time to report PCR results was 6.17 h compared to 57.28 h for culture results for bacterial pathogens...
March 6, 2024: Antibiotics
https://read.qxmd.com/read/38534675/impact-of-genital-infections-and-antibiotic-use-on-incidence-of-preterm-birth-a-retrospective-observational-study
#39
JOURNAL ARTICLE
Daniela Teodora Marti, Felix Bratosin, Ovidiu Rosca, Roxana Folescu, Cosmin Citu, Adrian Ratiu, Zoran Laurentiu Popa
This study investigates the complex interplay among genital infections, antibiotic usage, and preterm birth. This study aims to identify common genital pathogens associated with preterm births, assess the impact of various antibiotic treatments on pregnancy outcomes, and understand antibiotic resistance patterns among these pathogens. This study included 71 pregnant women who experienced preterm birth and 94 women with genital infections who delivered at term. Various maternal characteristics, medical history, signs and symptoms, gestational weight, gestational age, type of birth, vaginal pH, Nugent scores, and vaginal flora were analyzed...
March 5, 2024: Antibiotics
https://read.qxmd.com/read/38534667/antimicrobial-resistance-and-sports-the-scope-of-the-problem-implications-for-athletes-health-and-avenues-for-collaborative-public-health-action
#40
REVIEW
Ognjen Ožegić, Branka Bedenić, Sunčanica Ljubin Sternak, Mario Sviben, Jasminka Talapko, Iva Pažur, Ivana Škrlec, Ivan Segedi, Tomislav Meštrović
Antimicrobial resistance (AMR) poses a global threat, leading to increased mortality and necessitating urgent action-however, its impact on athletes and the world of sports has hitherto been neglected. Sports environments (including athletic and aquatic) exhibit high levels of microbial contamination, potentially contributing to the spread of resistant microorganisms during physical activities. Moreover, the literature suggests that travel for sports events may lead to changes in athletes' gut microbiomes and potentially impact their antibiotic resistance profiles, raising questions about the broader implications for individual and public/global health...
February 29, 2024: Antibiotics
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