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https://www.readbyqxmd.com/read/28749306/successful-treatment-of-digital-osteitis-by-intravenous-regional-perfusion-of-ceftiofur-in-an-african-elephant-loxodonta-africana
#1
Christopher J Dutton, Pauline G Delnatte, Simon R Hollamby, Graham J Crawshaw
A 41-yr-old African elephant ( Loxodonta africana ) presented with a swollen third digit of the left forelimb and a 2-cm hole in the pad. Corrective trimming, topical treatments, and an oral antibiotic resulted in apparent resolution; however, it reoccurred after 4 mo. Radiographs suggested bone lysis in the third phalanx, with the primary differential diagnosis being septic osteitis. Flushing with metronidazole solution and intravenous regional perfusion (IVRP) of the foot were commenced. A tourniquet was applied just above the carpus, an interdigital vein was identified by ultrasound, and into this vein 2 g (20 ml) of ceftiofur sodium solution, followed by 60 ml of heparinized saline, was administered...
June 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28749114/characteristics-and-outcomes-of-patients-with-hematological-malignancies-admitted-for-intensive-care-a-single-centre-experience
#2
Shafaq Maqsood, Farhana Badar, Abdul Hameed
Background and Purpose: Patients with hematological malignancies admitted to an intensive care unit (ICU) generally have a high mortality rate. The aim of our study was to assess the characteristics and outcomes of such patients and to identify factors predicting ICU mortality. Material and Methods: This retrospective chart review was conducted in the intensive care unit (ICU) of Shaukat Khanum Memorial Cancer Hospital and Research Centre over a period of 5 years, from January 2010 to January 2015. Results: Characteristics :A total of 213 patients were included in this study...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28748855/clinical-characteristics-and-endoscopic-endonasal-removal-of-foreign-bodies-within-sinuses-orbit-and-skull-base
#3
Yi-Hui Wen, Wei-Jian Hou, Wen-Bin Lei, Feng-Hong Chen, Xiao-Lin Zhu, Zhang-Feng Wang, Ren-Qiang Ma, Wei-Ping Wen
BACKGROUND: Foreign bodies within the sinuses, orbit, and skull base (FBSOS) are rare; hence, diagnosis and management guidelines are lacking. Endoscopic sinus surgery (ESS) removal is preferred because of the less invasiveness and minimal morbidity. This study was designed to summarize clinical experience with ESS management of FBSOS. METHODS: We retrospectively reviewed clinical manifestations, imaging findings, treatment, and outcomes in consecutive patients with ESS removal of FBSOS between 2004 and 2015 at a tertiary academic medical center...
August 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28748698/band-gap-engineering-of-titania-film-through-cobalt-regulation-for-oxidative-damage-of-bacteria-respiration-and-viability
#4
Jinhua Li, Jiaxing Wang, Donghui Wang, Geyong Guo, Kelvin Wai Kwok Yeung, Xianlong Zhang, Xuanyong Liu
Biomaterial-related bacterial infections cause patient suffering, mortality and extended periods of hospitalization, and impose a substantial burden on medical systems. In this context, understanding the interactions between nanomaterials and bacteria is clinically significant. Herein, TiO2-based heterojunctions including Co-TiO2, CoO-TiO2 and Co3O4-TiO2, were firstly designed by optimizing magnetron sputtering to establish a platform to explore the interactions between nanomaterials and bacteria. We found that the energy band bending and band gap narrowing were effectively promoted at the contact interface of the heterojunctions, which have the ability to induce abiotic reactive oxygen species formation...
July 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28748440/pharmaceuticals-released-from-senior-residences-occurrence-and-risk-evaluation
#5
Silvia Lacorte, Silvia Luis, Cristian Gómez-Canela, Teresa Sala-Comorera, Audrey Courtier, Benoit Roig, Ana Maria Oliveira-Brett, Claire Joannis-Cassan, Juan Ignacio Aragonés, Lucia Poggio, Thierry Noguer, Luisa Lima, Carlos Barata, Carole Calas-Blanchard
One of the main pursuits, yet most difficult, in monitoring studies is to identify the sources of environmental pollution. In this study, we have identified health-care facilities from south European countries as an important source of pharmaceuticals in the environment. We have estimated that compounds consumed in by the elderly and released from effluents of senior residences can reach river waters at a concentration higher than 0.01 μg/L, which is the European Medicines Agency (EMA) threshold for risk evaluation of pharmaceuticals in surface waters...
July 27, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28748396/disagreement-between-the-results-from-three-commercial-tests-for-the-detection-of-borrelia-specific-serum-antibodies-in-the-netherlands-associated-with-antibiotic-treatment-for-lyme-borreliosis-a-retrospective-study
#6
T van Gorkom, K Kremer, W Voet, D W Notermans, B J M Vlaminckx, S U C Sankatsing, S F T Thijsen
The diagnosis of Lyme borreliosis is challenging because of the often non-specific symptoms and persisting antibodies after infection. We investigated the diagnostic characteristics of two enzyme-linked immunosorbent assays (ELISAs) and an immunoblot for the detection of Borrelia-specific serum antibodies using different test strategies in individuals with and without antibiotic treatment for Lyme borreliosis. This retrospective study included healthy individuals, patients with active Lyme neuroborreliosis and patients treated for Lyme neuroborreliosis...
July 26, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28748309/interaction-of-zn-ii-bleomycin-a2-and-zn-ii-peplomycin-with-a-dna-hairpin-containing-the-5-gt-3-binding-site-in-comparison-with-the-5-gc-3-binding-site-studied-by-nmr-spectroscopy
#7
Shelby E Follett, Azure D Ingersoll, Sally A Murray, Teresa M Reilly, Teresa E Lehmann
Bleomycins are a group of glycopeptide antibiotics synthesized by Streptomyces verticillus that are widely used for the treatment of various neoplastic diseases. These antibiotics have the ability to chelate a metal center, mainly Fe(II), and cause site-specific DNA cleavage. Bleomycins are differentiated by their C-terminal regions. Although this antibiotic family is a successful course of treatment for some types of cancers, it is known to cause pulmonary fibrosis. Previous studies have identified that bleomycin-related pulmonary toxicity is linked to the C-terminal region of these drugs...
July 26, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28748192/extranodal-nk-t-cell-lymphoma-nasal-type-presenting-as-refractory-pseudomonas-aeruginosa-facial-cellulitis
#8
Erika Reategui Schwarz, Katerina G Oikonomou, Megan Reynolds, Juliette Kim, Rajeev L Balmiki, Stephanie A Sterling
Extranodal natural killer T-cell lymphoma, nasal type (ENKL), formerly called lethal midline granuloma or angiocentric T-cell lymphoma, is a predominantly extranodal non-Hodgkin lymphoma characterized by vascular damage, necrosis, and an association with Epstein-Barr virus. In the United States, it is more frequently seen in Asian, Asian Pacific Islander, and Hispanic descent populations and is more prevalent in males in their fifth decade. Clinical presentation of NK nasal lymphoma most commonly involves epistaxis; obstruction; discharge; destructive mass in sinuses, palate, and nose; and skin ulceration...
July 2017: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/28748087/antimicrobial-effects-of-lysophosphatidylcholine-on-methicillin-resistant-staphylococcus-aureus
#9
Haruko Miyazaki, Naoko Midorikawa, Saki Fujimoto, Natsumi Miyoshi, Hideto Yoshida, Tetsuya Matsumoto
OBJECTIVES: Methicillin-resistant Staphylococcus aureus (MRSA) is an important health care-associated and community-associated pathogen and causes a large number of infections worldwide. For the purpose of application to topical treatment of MRSA infection, we examined the antimicrobial effects of lysophosphatidylcholine (LPC) on MRSA strains. We also investigated the combination effect of LPC and gentamicin on MRSA growth. METHODS: The LPC minimum inhibitory concentrations (MIC) for Gram-positive (S...
July 2017: Therapeutic Advances in Infectious Disease
https://www.readbyqxmd.com/read/28747897/identification-of-emerging-human-mastitis-pathogens-by-maldi-tof-and-assessment-of-their-antibiotic-resistance-patterns
#10
María Marín, Rebeca Arroyo, Irene Espinosa-Martos, Leónides Fernández, Juan M Rodríguez
Lactational mastitis constitutes one of the main causes of undesired weaning, depriving the mother-infant pair from the benefits of breastfeeding; therefore, this condition should be considered a relevant public health issue. The role of specific microorganisms remains unclear since human milk cultures and antibiotic susceptibility testing (AST) are not routinely performed, despite the fact that this would be key to ensure an early and effective diagnosis and treatment. The objective of this study was to describe the culturable microbial diversity in 647 milk samples from breastfeeding women with clinical symptoms of mastitis by Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF) VITEK MS technology and to analyze the antimicrobial susceptibility profiles of a collection of isolates from these samples by the VITEK 2 AST system...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28747785/discovery-of-monoclonal-antibodies-cross-reactive-to-novel-subserotypes-of-k-pneumoniae-o3
#11
Luis M Guachalla, Katarina Stojkovic, Katharina Hartl, Marta Kaszowska, Yadhu Kumar, Benjamin Wahl, Tobias Paprotka, Eszter Nagy, Jolanta Lukasiewicz, Gábor Nagy, Valéria Szijártó
Klebsiella pneumoniae is responsible for nosocomial infections causing significant morbidity and mortality. Treatment of newly emerging multi-drug resistant strains is hampered due to severely limited antibiotic choices. Passive immunization targeting LPS O-antigens has been proposed as an alternative therapeutic option, given the limited variability of Klebsiella O-antigens. Here we report that the O3 serogroup, previously considered to have uniform O-antigen built of mannan, represents three different subtypes differing in the number of mannose residues within the O-antigen repeating units...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28747418/a-complication-of-meningitis-and-infective-endocarditis-due-to-streptococcus-pyogenes
#12
Kosuke Inoue, Akiyoshi Hagiwara, Akio Kimura, Norio Ohmagari
We described a rare case of meningitis and infective endocarditis (IE) due to Streptococcus pyogenes. An 80-year-old woman was admitted to our hospital with unconsciousness. Glasgow Coma Scale was E1V3M5. We diagnosed her with acute meningitis due to S. pyogenes and started treatment using ceftriaxone. In spite of the improvement of her unconscious state, she developed a new-onset systolic murmur on day 13, and echocardiography revealed severe mitral valve regurgitation with vegetation. Therefore, we also diagnosed her with IE and continued the antibiotics for 6 weeks after we confirmed the negative blood cultures...
July 26, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28747205/detection-of-antibiotic-resistance-is-essential-for-gonorrhoea-point-of-care-testing-a-mathematical-modelling-study
#13
Stephanie M Fingerhuth, Nicola Low, Sebastian Bonhoeffer, Christian L Althaus
BACKGROUND: Antibiotic resistance is threatening to make gonorrhoea untreatable. Point-of-care (POC) tests that detect resistance promise individually tailored treatment, but might lead to more treatment and higher levels of resistance. We investigate the impact of POC tests on antibiotic-resistant gonorrhoea. METHODS: We used data about the prevalence and incidence of gonorrhoea in men who have sex with men (MSM) and heterosexual men and women (HMW) to calibrate a mathematical gonorrhoea transmission model...
July 26, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28747198/population-based-prevalence-survey-of-follicular-trachoma-and-trachomatous-trichiasis-in-the-casamance-region-of-senegal
#14
Emma M Harding-Esch, Julbert Kadimpeul, Boubacar Sarr, Awa Sane, Souleymane Badji, Mass Laye, Ansumana Sillah, Sarah E Burr, David MacLeod, Anna R Last, Martin J Holland, David C Mabey, Robin L Bailey
BACKGROUND: Trachoma, caused by ocular infection with Chlamydia trachomatis, is the leading infectious cause of blindness worldwide. We conducted the first population-based trachoma prevalence survey in the Casamance region of Senegal to enable the Senegalese National Eye Care Programme (NECP) to plan its trachoma control activities. The World Health Organization (WHO) guidelines state that any individual with trachomatous trichiasis (TT) should be offered surgery, but that surgery should be prioritised where the prevalence is >0...
July 26, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28747160/adverse-events-in-women-and-children-who-have-received-intrapartum-antibiotic-prophylaxis-treatment-a-systematic-review
#15
Farah Seedat, Chris Stinton, Jacoby Patterson, Julia Geppert, Bee Tan, Esther R Robinson, Noel Denis McCarthy, Olalekan A Uthman, Karoline Freeman, Samantha Ann Johnson, Hannah Fraser, Colin Stewart Brown, Aileen Clarke, Sian Taylor-Phillips
BACKGROUND: Adverse events from intrapartum antibiotic prophylaxis (IAP) are poorly documented yet essential to inform clinical practice for neonatal group B Streptococcus (GBS) disease prevention. In this systematic review, we appraised and synthesised the evidence on the adverse events of IAP in the mother and/or her child. METHODS: We searched MEDLINE, MEDLINE In-Process & Other Non-Indexed Citations, EMBASE, Cochrane, and Science Citation Index from date of inception until October 16th 2016...
July 26, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28747159/a-case-report-of-ct-diagnosed-renal-infarct-secondary-to-syphilitic-aortitis
#16
Maaike Spaltenstein, Françoise Humbert, Diem-Lan Vu, Ilker Uçkay, Gregor John
BACKGROUND: Even though reported cases of syphilis have been increasing, cases of tertiary syphilis remain extremely rare. The majority of our knowledge with regard to complications of syphilis such as aortitis was acquired before the advent of relatively modern technologies such as CT, MRI and PET. This case report presents a rare case of syphilitic aortitis associated with a renal infarct caused by a peripheral arterial embolism diagnosed by CT. CASE PRESENTATION: We present a young man with sudden abdominal pain and flank tenderness without fever...
July 26, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28747056/fecal-transplantation-as-a-treatment-for-clostridium-difficile-infection-in-patients-with-ulcerative-colitis
#17
Marta Izquierdo Romero, Pilar Varela Trastoy, Alejo Mancebo Mata
Clostridium difficile (CD) infection is currently the most frequent etiology of nosocomial diarrhea. Besides, its incidence is progressively increasing in ambulatory patients. Inflammatory bowel disease (IBD) is a risk factor of CD infection itself, but also due to the regular immunosuppressive treatment used in these patients. At the present time, fecal transplantation (FT) is a safe and cost-effective alternative if the previous antibiotic treatments have failed. Similar outcomes between patients with IBD and general population have been reported...
July 27, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28747007/ozone-pretreatment-of-process-waste-water-generated-in-course-of-fluoroquinolone-production
#18
Fares Daoud, David Pelzer, Sebastian Zuehlke, Michael Spiteller, Oliver Kayser
During production of active pharmaceutical ingredients, process waste water is generated at several stages of manufacturing. Whenever possible, the resulting waste water will be processed by conventional waste water treatment plants. Currently, incineration of the process waste water is the method to eliminate compounds with high biological activity. Thus, ozone treatment followed by biological waste water treatment was tested as an alternative method. Two prominent representatives of the large group of fluoroquinolone antibiotics (ciprofloxacin and moxifloxacin) were investigated, focussing on waste water of the bulk production...
July 12, 2017: Chemosphere
https://www.readbyqxmd.com/read/28746884/effects-of-single-and-combined-use-of-bacteriophages-and-antibiotics-to-inactivate-escherichia-coli
#19
Nádia Valério, Cristiana Oliveira, Vânia Jesus, Tatiana Branco, Carla Pereira, Catarina Moreirinha, Adelaide Almeida
A major concern of phage therapy is the emergency of phage-resistant mutants. This limitation can be overcome by the combined use of phages and antibiotics. It has been shown that the combination of antibiotics and phages is an alternative that cannot only be effective at reducing bacterial numbers, but also to contribute to the management of resistance levels. However, this view has only been discussed with regard to antibiotic resistance and not to control phage-mutant emergence. In our study we compared not only the resistance of the bacteria to the four antibiotics tested with and without phages addition, but also the resistance to the phages in the presence and absence of antibiotics...
July 23, 2017: Virus Research
https://www.readbyqxmd.com/read/28746018/splenic-abscess-in-immunocompetent-patients-managed-primarily-without-splenectomy-a-series-of-7-cases
#20
S Divyashree, Nikhil Gupta
INTRODUCTION: Splenic abscesses are rare in immunocompetent adults. Despite advances in diagnosis and treatment, these abscesses are still potentially life threatening. Various factors have been reported to predispose otherwise immunocompetent adults to splenic abscesses. Splenectomy was once considered the "gold standard" treatment. However, the trend is shifting to a conservative approach. CASE DESCRIPTION: We describe seven cases of splenic abscess in immunocompetent adults, the cause of which ranged from tuberculosis to salmonella and was as rare as Plasmodium vivax...
2017: Permanente Journal
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