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JOURNAL ARTICLE
Jingjing Zhang, Xuan Yang, Guofang Xu, Biswal Basanta Kumar, Rajasekhar Balasubramanian
Visible light-driven photocatalytic oxidation by photogenerated holes has immense potential for environmental remediation applications. While the electron-mediated photoreduction reactions are often at the spotlight, active holes possess a remarkable oxidation capacity that can degrade recalcitrant organic pollutants, resulting in non-toxic byproducts. However, the random charge transfer and rapid recombination of electron-hole pairs hinder the accumulation of long-lived holes at the reaction center. Herein, we report a novel method employing defect-engineered indium (In) single atom photocatalysts, dispersed in carbon nitride foam (In-Nv-CNF), to overcome these challenges and make further advances in photocatalysis...
May 11, 2024: Advanced Materials
#2
JOURNAL ARTICLE
Ren Lin, Hai-Peng He, Yang Zhao, Jun-Bing Lv, Jia-Xin Peng, Heng-Hui Yin
OBJECTIVE: The objective was to present our experience on managing mycotic infrarenal abdominal aortic aneurysm (MIAAA) through a retrospective cohort study. METHODS: Data of patients with MIAAA managed in our center from July 2016 to October 2022 were retrospectively analyzed. The diagnosis of MIAAA was made based on: (1) preoperative clinical signs of infection; (2) elevated serologic infection parameters; (3) para-aneurysmal infection features on enhanced computed tomography; and (4) positive blood or tissue cultures...
May 11, 2024: Journal of Endovascular Therapy
#3
JOURNAL ARTICLE
Carlos Ramos-Acosta, Laura Huerta-Pantoja, Milton Eduardo Salazar-Hidalgo, Elsa Mayol, Selene Jiménez-Vega, Pablo García-Peña, Jenifeer Jordi-Cruz, Cristina Baquero, Almudena Porras, Belén Íñigo-Rodríguez, Celina M Benavente, Andrea R López-Pastor, Irene Gómez-Delgado, Elena Urcelay, Francisco Javier Candel, Eduardo Anguita
Multiple myeloma is an incurable plasma cell malignancy. Most patients end up relapsing and developing resistance to antineoplastic drugs, like bortezomib. Antibiotic tigecycline has activity against myeloma. This study analyzed tigecycline and bortezomib combination on cell lines and plasma cells from myeloma patients. Apoptosis, autophagic vesicles, mitochondrial mass, mitochondrial superoxide, cell cycle, and hydrogen peroxide were studied by flow cytometry. In addition, mitochondrial antioxidants and electron transport chain complexes were quantified by reverse transcription real-time PCR (RT-qPCR) or western blot...
April 30, 2024: International Journal of Molecular Sciences
#4
JOURNAL ARTICLE
Damiana-Maria Vulturar, Benoît Pilmis, Claire Rouzaud, Anne Gigandon, Gaëlle Dauriat, Séverine Feuillet-Soummer, Liviu-Stefan Moaca, Elie Fadel, Olaf Mercier, Dominique Fabre, Olivier Lortholary, Jérôme Le Pavec
Bordetella hinzii (B. hinzii) , a Gram-negative bacillus commonly associated with respiratory infections in animals, has garnered attention for its sporadic cases in humans, particularly in immunocompromised individuals. Despite its opportunistic nature, there remains limited understanding regarding its pathogenicity, diagnostic challenges, and optimal treatment strategies, especially in the context of immunosuppression. Herein, we present the first documented case of acute bronchitis caused by B. hinzii in an immunocompromised patient following double-lung transplantation...
April 26, 2024: International Journal of Molecular Sciences
#5
JOURNAL ARTICLE
Niclas Huber, Natascha Gundling, Maria Thurow, Uwe Ligges, Martina Hoedemaker
It was the aim of this study to examine whether the usage of the vaccine COXEVAC® (Ceva Santé Animale) could reduce the consumption of antibiotics in Q-fever-positive dairy farms. Additionally, the effects of other herd-level factors on the consumption of antibiotics were investigated. A total of 36 farms with vaccination and 13 farms without vaccination participated in this longitudinal cohort study. In all herds, Coxiella burnetii had been directly or indirectly diagnosed. To compare the treatment frequency of antibiotics between the vaccinated group and the non-vaccinated group, the consumption of antibiotics for each farm was collected using the veterinary documents about the application and delivery of antibiotics...
May 3, 2024: Animals: An Open Access Journal From MDPI
#6
JOURNAL ARTICLE
Alison Collins, Cherie Collins
Proliferative enteropathy (PE) is characterized by diarrhea and reduced weight gains in growing pigs and intestinal hemorrhage in finishers. Vaccination, antibiotic medication, and improved hygiene can control PE, but their efficacy depends upon the epidemiology of PE. This study monitored the timing and severity of PE in 84 commercial pens across seven treatments, including disinfection, vaccination, no treatment, medication with olaquindox (50, 25 and 12.5 ppm), and combined disinfection and vaccination. Vaccination with or without lime disinfection suppressed clinical signs of PE and reduced the number of excreted L...
April 30, 2024: Animals: An Open Access Journal From MDPI
#7
JOURNAL ARTICLE
Jing Dong, Yuze Zhang, Qiuhong Yang, Yongtao Liu, Shun Zhou, Xiaohui Ai
Sortase A (SrtA) is responsible for anchoring surface proteins to the cell wall, and has been identified as a promising target developing anti-infective drugs of Gram-positive bacteria. The aim of the study was to identify inhibitors of Streptococcus agalactiae ( S. agalactiae ) SrtA from natural compounds to overcome the spread of antibiotic resistance in aquaculture. Here, we found that the MIC of fraxetin against S. agalactiae was higher than 256 μg/mL, indicating that fraxetin had no anti- S. agalactiae activity...
April 29, 2024: Animals: An Open Access Journal From MDPI
#8
JOURNAL ARTICLE
Jing Zuo, Yingying Quan, Jinpeng Li, Yue Li, Dong Song, Xingping Li, Yuxin Wang, Li Yi, Yang Wang
Streptococcus suis ( S. suis ) is a zoonotic pathogen with a global distribution, which causes serious diseases in both humans and animals and economic losses in the swine industry. As antibiotic resistance increases, there is an urgent imperative to explore novel antibacterial alternatives. In the present study, we selected the anticancer drug 5-fluorouracil (5-FU) approved by the Food and Drug Administration (FDA) as a candidate drug to treat S. suis infections. The results showed that various pathogens, especially S...
April 24, 2024: Animals: An Open Access Journal From MDPI
#9
JOURNAL ARTICLE
Sofia Roero, Giulia Benedetto, Lorena Charrier, Agata Ingala, Alice Ronco, Teresa Fea, Valentina Borgarello, Carlotta Bossotti, Silvana Arduino, Alberto Revelli
Objectives : Twin pregnancy implies a higher risk of preterm birth and, consequently, higher neonatal morbidity and mortality. In singleton pregnancies, infections of the lower genital tract (LGTIs) and bacterial vaginosis are associated with preterm labor, and their early detection has been proven effective in reducing complications like the preterm premature rupture of membranes (pPROM) and preterm delivery. The same evidence, however, is lacking for twin pregnancies. This study aimed to evaluate whether the early identification and treatment of LGTIs or bacterial vaginosis in asymptomatic women with twin pregnancy could reduce the rate of miscarriages, pPROM, and preterm birth...
May 2, 2024: Journal of Clinical Medicine
#10
JOURNAL ARTICLE
Tobias Pantel, Klaus Christian Mende, Martin Stangenberg, Malte Mohme, Theresa Mohme, Frank Floeth, Sven Oliver Eicker, Marc Dreimann
Background : Spondylodiscitis is an infectious disease affecting an intervertebral disc and the adjacent vertebral bodies and is often the complication of a distant focus of infection. This study aims to ascertain the regional and hospital-specific disparities in bacterial patterns and resistance profiles in spontaneous and iatrogenic spondylodiscitis and their implications for patient treatment. Methods: We enrolled patients from two German hospitals, specifically comparing a university hospital (UVH) with a peripheral non-university hospital (NUH)...
April 26, 2024: Journal of Clinical Medicine
#11
REVIEW
Mahmoud G El Baassiri, Zachariah Raouf, Sarah Badin, Alejandro Escobosa, Chhinder P Sodhi, Isam W Nasr
Traumatic brain injury (TBI) is a chronic and debilitating disease, associated with a high risk of psychiatric and neurodegenerative diseases. Despite significant advancements in improving outcomes, the lack of effective treatments underscore the urgent need for innovative therapeutic strategies. The brain-gut axis has emerged as a crucial bidirectional pathway connecting the brain and the gastrointestinal (GI) system through an intricate network of neuronal, hormonal, and immunological pathways. Four main pathways are primarily implicated in this crosstalk, including the systemic immune system, autonomic and enteric nervous systems, neuroendocrine system, and microbiome...
May 10, 2024: Journal of Neuroinflammation
#12
JOURNAL ARTICLE
Lisa H Amir, Sharinne B Crawford, Meabh Cullinane, Luke E Grzeskowiak
BACKGROUND: Mastitis is a common reason new mothers visit their general practitioner (GP). In Australia, the Therapeutic Guidelines: Antibiotic provides practical advice to GPs managing a range of infections, including mastitis. It is not known if Australian GPs prescribe antibiotics and order investigations as recommended for the management of mastitis. METHODS: A convergent mixed methods design integrated quantitative analysis of a general practice dataset with analysis of interviews with GPs...
May 10, 2024: BMC Prim Care
#13
JOURNAL ARTICLE
Daniela Neudecker, Nora Fritisch, Thomas Sutter, Lenette Lu, Pei Lu, Marc Tebruegge, Begoña Santiago-Garcia, Nicole Ritz
BACKGROUND: Tuberculosis (TB) poses a major public health challenge, particularly in children. A substantial proportion of children with TB disease remain undetected and unconfirmed. Therefore, there is an urgent need for a highly sensitive point-of-care test. This study aims to assess the performance of serological assays based on various antigen targets and antibody properties in distinguishing children (0-18 years) with TB disease (1) from healthy TB-exposed children, (2) children with non-TB lower respiratory tract infections, and (3) from children with TB infection...
May 10, 2024: BMC Infectious Diseases
#14
JOURNAL ARTICLE
Wei Zhuang, Tao He, Jianyekai Tuerheng, Guang He, Bao-Li Wang, Yi-Heng Yang, Lan Zhang, Xian-Zhe Dong, Sheng-Yan Xi
BACKGROUND: Neurobrucellosis (NB) is a rare and serious complication of brucellosis. Its clinical manifestations vary, with no obvious specificity. At present, there is no clear clinical diagnosis or treatment for reference. In this study, we retrospectively analyzed the clinical data for 21 patients with NB to provide reference data for its further study. METHODS: We analyzed the epidemiological and clinical manifestations, laboratory tests, imaging examinations, cerebrospinal fluid, and treatment plans of 21 patients diagnosed with NB in the Department of Neurology, Xuanwu Hospital, Capital Medical University Beijing, China...
May 10, 2024: BMC Infectious Diseases
#15
JOURNAL ARTICLE
Hervé Nicoloff, Karin Hjort, Dan I Andersson, Helen Wang
Heteroresistance is a medically relevant phenotype where small antibiotic-resistant subpopulations coexist within predominantly susceptible bacterial populations. Heteroresistance reduces treatment efficacy across diverse bacterial species and antibiotic classes, yet its genetic and physiological mechanisms remain poorly understood. Here, we investigated a multi-resistant Klebsiella pneumoniae isolate and identified three primary drivers of gene dosage-dependent heteroresistance for several antibiotic classes: tandem amplification, increased plasmid copy number, and transposition of resistance genes onto cryptic plasmids...
May 10, 2024: Nature Communications
#16
JOURNAL ARTICLE
Martin Thornhill, Bernard Prendergast, Mark Dayer, Ash Frisby, Peter Lockhart, Larry M Baddour
National Institute for Health and Care Excellence (NICE) guidelines are ambiguous over the need for patients at increased risk of infective endocarditis (IE) to receive antibiotic prophylaxis (AP) prior to invasive dental procedures (IDPs), and this has caused confusion for patients and dentists alike. Moreover, the current law on consent requires clinicians to ensure that patients are made aware of any material risk they might be exposed to by any proposed dental treatment and what can be done to ameliorate this risk, so that the patient can decide for themselves how they wish to proceed...
May 2024: British Dental Journal
#17
JOURNAL ARTICLE
Biljana Kakaraskoska Boceska, Tuba Vilken, Basil Britto Xavier, Tomislav Kostyanev, Qiang Lin, Christine Lammens, Sally Ellis, Seamus O'Brien, Renata Maria Augusto da Costa, Aislinn Cook, Neal Russell, Julia Bielicki, Amy Riddell, Wolfgang Stohr, Ann Sarah Walker, Eitan Naaman Berezin, Emmanuel Roilides, Maia De Luca, Lorenza Romani, Daynia Ballot, Angela Dramowski, Jeannette Wadula, Sorasak Lochindarat, Suppawat Boonkasidecha, Flavia Namiiro, Hoang Thi Bich Ngoc, Minh Dien Tran, Tim R Cressey, Kanchana Preedisripipat, James A Berkley, Robert Musyimi, Charalampos Zarras, Trusha Nana, Andrew Whitelaw, Cely Barreto da Silva, Prenika Jaglal, Willy Ssengooba, Samir K Saha, Mohammad Shahidul Islam, Marisa Marcia Mussi-Pinhata, Cristina Gardonyi Carvalheiro, Laura J V Piddock, Paul T Heath, Surbhi Malhotra-Kumar, Michael Sharland, Youri Glupczynski, Herman Goossens
Gram-negative bacteria (GNB) are a major cause of neonatal sepsis in low- and middle-income countries (LMICs). Although the World Health Organization (WHO) reports that over 80% of these sepsis deaths could be prevented through improved treatment, the efficacy of the currently recommended first- and second-line treatment regimens for this condition is increasingly affected by high rates of drug resistance. Here we assess three well known antibiotics, fosfomycin, flomoxef and amikacin, in combination as potential antibiotic treatment regimens by investigating the drug resistance and genetic profiles of commonly isolated GNB causing neonatal sepsis in LMICs...
May 10, 2024: Nature Communications
#18
JOURNAL ARTICLE
Dariusz Kawecki, Anna Majewska, Jarosław Czerwiński
BACKGROUND: Pneumonia is a major cause of hospitalization and has a substantial impact on health care costs. Diagnosis and treatment of pneumonia in solid organ transplant (SOT) patients remain a challenge for clinicians in the emergency department. This study aimed to evaluate demographic features, clinical patterns, history of hospitalization, and diagnosis of adult patients after organ(s) transplantation (liver, kidney, pancreas) with severe pneumonia requiring hospitalization. The aim is to determine whether patients undergoing SOT receive or require specific care and whether they need to be prioritized...
May 9, 2024: Transplantation Proceedings
#19
JOURNAL ARTICLE
Balázs Babarczy, Ágnes Hajdu, Ria Benko, Mária Matuz, Renáta Papp, Pantelis Antoniou, Ketevan Kandelaki, Danilo Lo Fo Wong, Sahil Khan Warsi
OBJECTIVES: Inappropriate antibiotic prescribing is a major cause of antimicrobial resistance (AMR). The aim of this study was to explore paediatric general practitioners' (GP Peds) antibiotic prescription practice in suspected respiratory tract infections (RTIs), using the capability-opportunity-motivation-behaviour framework. DESIGN: The design is a qualitative study based on individual, semistructured telephone or virtual interviews. SETTING: Paediatric general practice in Hungary...
May 10, 2024: BMJ Open
#20
REVIEW
John McAteer, Pranita D Tamma
In the article, the authors review antibiotic treatment options for both acute uncomplicated UTI and complicated UTI. In addition, they review alternative regimens which are needed in the setting of drug-resistant pathogens including vancomycin-resistant Enterococcus, -extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-E), carbapenem-resistant Enterobacterales, and carbapenem-resistant Pseudomonas, which are encountered with more frequency.
June 2024: Infectious Disease Clinics of North America
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