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“Mathew williams”

Steven P Williams, Andrew S Barthorpe, Howard Lightfoot, Mathew J Garnett, Ultan McDermott
This corrects the article DOI: 10.1038/sdata.2017.139.
October 9, 2018: Scientific Data
Daniel R Saban, Robin R Hodges, Rose Mathew, Nancy J Reyes, Chen Yu, Rebecca Kaye, William Swift, Nora Botten, Charles N Serhan, Darlene A Dartt
Severe, chronic eye allergy is an understudied, vision-threatening condition. Treatments remain limited. We used a mouse model of severe allergic eye disease (AED) to determine whether topical application of the pro-resolution mediator Resolvin D1 (RvD1) terminates the response. AED was induced by injection of ovalbumin (OVA) followed by topical challenge of OVA daily. RvD1 was applied topically prior to OVA. Clinical symptoms were scored. Eye washes were assayed for MUC5AC. After 7 days, eyes were removed and the number of goblet cells, T helper cell responses and presence of immune cells in draining lymph nodes and conjunctiva determined...
October 2, 2018: Mucosal Immunology
Jingtao Lilue, Anthony G Doran, Ian T Fiddes, Monica Abrudan, Joel Armstrong, Ruth Bennett, William Chow, Joanna Collins, Stephan Collins, Anne Czechanski, Petr Danecek, Mark Diekhans, Dirk-Dominik Dolle, Matt Dunn, Richard Durbin, Dent Earl, Anne Ferguson-Smith, Paul Flicek, Jonathan Flint, Adam Frankish, Beiyuan Fu, Mark Gerstein, James Gilbert, Leo Goodstadt, Jennifer Harrow, Kerstin Howe, Ximena Ibarra-Soria, Mikhail Kolmogorov, Chris J Lelliott, Darren W Logan, Jane Loveland, Clayton E Mathews, Richard Mott, Paul Muir, Stefanie Nachtweide, Fabio C P Navarro, Duncan T Odom, Naomi Park, Sarah Pelan, Son K Pham, Mike Quail, Laura Reinholdt, Lars Romoth, Lesley Shirley, Cristina Sisu, Marcela Sjoberg-Herrera, Mario Stanke, Charles Steward, Mark Thomas, Glen Threadgold, David Thybert, James Torrance, Kim Wong, Jonathan Wood, Binnaz Yalcin, Fengtang Yang, David J Adams, Benedict Paten, Thomas M Keane
We report full-length draft de novo genome assemblies for 16 widely used inbred mouse strains and find extensive strain-specific haplotype variation. We identify and characterize 2,567 regions on the current mouse reference genome exhibiting the greatest sequence diversity. These regions are enriched for genes involved in pathogen defence and immunity and exhibit enrichment of transposable elements and signatures of recent retrotransposition events. Combinations of alleles and genes unique to an individual strain are commonly observed at these loci, reflecting distinct strain phenotypes...
October 1, 2018: Nature Genetics
Joseph A Delaney, Robin M Nance, Bridget M Whitney, Heidi M Crane, Jessica Williams-Nguyen, Mathew J Feinstein, Robert C Kaplan, David B Hanna, Matthew J Budoff, Daniel R Drozd, Greer Burkholder, Michael J Mugavero, William C Mathews, Richard D Moore, Joseph J Eron, Peter W Hunt, Elvin Geng, Michael S Saag, Mari M Kitahata, Susan R Heckbert
BACKGROUND: People living with human immunodeficiency virus (HIV) are at risk of increased myocardial infarction (MI). Cumulative HIV viral load (VL) has been proposed as a better measure of HIV inflammation than other measures of VL, like baseline VL, but its associations with MI are not known. METHODS: The multi-site Centers for AIDS Research Network of Integrated Clinical Systems (CNICS) cohort includes clinical data and centrally adjudicated MI with distinction between atheroembolic MI (type 1) and MI related to supply-demand mismatch (type 2)...
September 28, 2018: Epidemiology
Anthony T Fojo, Catherine R Lesko, Keri L Calkins, Richard D Moore, Mary E McCaul, Heidi E Hutton, William C Mathews, Heidi Crane, Katerina Christopoulos, Karen Cropsey, Michael J Mugavero, Kenneth Mayer, Brian W Pence, Bryan Lau, Geetanjali Chander
Few studies examine how depression and substance use interact to affect HIV control. In 14,380 persons with HIV (PWH), we used logistic regression and generalized estimating equations to evaluate how symptoms of depression interact with alcohol, cocaine, opioid, and methamphetamine use to affect subsequent retention in care, maintaining an active prescription for ART, and consistent virologic suppression. Among PWH with no or mild depressive symptoms, heavy alcohol use had no association with virologic suppression (OR 1...
September 29, 2018: AIDS and Behavior
Nathan A Jud, Michael D D'Emic, Scott A Williams, Josh C Mathews, Katie M Tremaine, Janok Bhattacharya
The diversification of flowering plants and marked turnover in vertebrate faunas during the mid-Cretaceous transformed terrestrial communities, but the transition is obscured by reduced terrestrial deposition attributable to high sea levels. We report a new fossil assemblage from multiple localities in the Upper Cretaceous Ferron Sandstone Member of the Mancos Shale Formation in Utah. The fossils date to the Turonian, a severely underrepresented interval in the terrestrial fossil record of North America. A large silicified log (maximum preserved diameter, 1...
September 2018: Science Advances
George B Sigal, Abraham Pinter, Todd L Lowary, Masanori Kawasaki, Andra Li, Anu Mathew, Michael Tsionsky, Ruixiang Blake Zheng, Tatiana Plisova, Ke Shen, Kiyonori Katsuragi, Alok Choudhary, William J Honnen, Payam Nahid, Claudia M Denkinger, Tobias Broger
The only currently commercialized point-of-care assay for tuberculosis (TB) that measures Lipoarabinomannan (LAM) in urine (Alere LF-LAM) has insufficient sensitivity. We evaluated the potential of 100 novel monoclonal antibody pairs targeting a variety of LAM epitopes on a sensitive electrochemiluminescence platform to improve the diagnostic accuracy. In the screening many antibody pairs showed high reactivity to purified LAM, but performed poorly at detecting urinary LAM in clinical samples suggesting differences in antigen structure and immunoreactivity of the different LAM sources...
September 26, 2018: Journal of Clinical Microbiology
Jackson J Liang, Benjamin A D'Souza, Brian P Betensky, Erica S Zado, Benoit Desjardins, Pasquale Santangeli, William W Chik, David S Frankel, David J Callans, Gregory E Supple, Mathew D Hutchinson, Sanjay Dixit, Robert D Schaller, Fermin C Garcia, David Lin, Michael P Riley, Francis E Marchlinski
OBJECTIVES: This study sought to characterize septal substrate in patients with nonischemic left ventricular cardiomyopathy (NILVCM) undergoing ventricular tachycardia (VT) ablation. BACKGROUND: The interventricular septum is an important site of VT substrate in NILVCM. METHODS: The authors studied 95 patients with NILVCM and VT. Electroanatomic mapping using standard bipolar (<1.5 mV) and unipolar (<8.3 mV) low-voltage criteria identified septal scar location and size...
September 2018: JACC. Clinical Electrophysiology
Andrew J Robinson, Muluneh Tamiru, Rachel Salby, Clayton Bolitho, Andrew Williams, Simon Huggard, Eva Fisch, Kathryn Unsworth, James Whelan, Mathew G Lewsey
BACKGROUND: The genome-wide expression profile of genes in different tissues/cell types and developmental stages is a vital component of many functional genomic studies. Transcriptome data obtained by RNA-sequencing (RNA-Seq) is often deposited in public databases that are made available via data portals. Data visualization is one of the first steps in assessment and hypothesis generation. However, these databases do not typically include visualization tools and establishing one is not trivial for users who are not computational experts...
September 19, 2018: BMC Plant Biology
Robert Marlin, Ankita Kadakia, Brandon Ethridge, William C Mathews
PURPOSE: The aims of this study were (1) to evaluate current physician attitudes toward homosexuality and homosexual, transgender, and HIV-positive individuals and (2) to compare current attitudes of those from prior surveys of the same population, the San Diego County medical community. METHODS: An online survey was conducted during November-December 2017 to assess general attitudes toward homosexuality and medically focused items that addressed homosexual orientation, transgender identity, and HIV...
October 2018: LGBT Health
Lily M van Eeden, Ann Eklund, Jennifer R B Miller, José Vicente López-Bao, Guillaume Chapron, Mikael R Cejtin, Mathew S Crowther, Christopher R Dickman, Jens Frank, Miha Krofel, David W Macdonald, Jeannine McManus, Tara K Meyer, Arthur D Middleton, Thomas M Newsome, William J Ripple, Euan G Ritchie, Oswald J Schmitz, Kelly J Stoner, Mahdieh Tourani, Adrian Treves
Carnivore predation on livestock often leads people to retaliate. Persecution by humans has contributed strongly to global endangerment of carnivores. Preventing livestock losses would help to achieve three goals common to many human societies: preserve nature, protect animal welfare, and safeguard human livelihoods. Between 2016 and 2018, four independent reviews evaluated >40 years of research on lethal and nonlethal interventions for reducing predation on livestock. From 114 studies, we find a striking conclusion: scarce quantitative comparisons of interventions and scarce comparisons against experimental controls preclude strong inference about the effectiveness of methods...
September 2018: PLoS Biology
Anahita Dastur, AHyun Choi, Carlotta Costa, Xunqin Yin, August F Williams, Joseph D McClanaghan, Max Greenberg, Justine E Roderick, Neha U Patel, Jessica L Boisvert, Ultan McDermott, Mathew J Garnett, Jorge Almenara, Steven Grant, Kathryn Rizzo, Jeffrey A Engelman, Michelle A Kelliher, Anthony C Faber, Cyril H Benes
PURPOSE: Effective targeted therapies are lacking for refractory and relapsed T-cell Acute Lymphoblastic Leukemia (T-ALL). Suppression of the NOTCH pathway using gamma-secretase inhibitors (GSIs) is toxic and clinically not effective. The goal of this study was to identify alternative therapeutic strategies for T-ALL. EXPERIMENTAL DESIGN: We performed a comprehensive analysis of our high throughput drug screen across hundreds of human cell lines including fifteen T-ALL models...
September 17, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Fidel A Desir, Catherine R Lesko, Richard D Moore, Michael A Horberg, Cherise Wong, Heidi M Crane, Michael Silverberg, Jennifer E Thorne, Beth Rachlis, Charles Rabkin, Angel M Mayor, William C Mathews, Keri N Althoff
Background: The United States National HIV/AIDS Strategy established goals to reduce disparities in retention in human immunodeficiency virus (HIV) care, antiretroviral therapy (ART) use, and viral suppression. The impact of sex, age, and sexual HIV acquisition risk (ie, heterosexual vs same-sex contact) on the magnitude of HIV-related racial/ethnic disparities is not well understood. Methods: We estimated age-stratified racial/ethnic differences in the 5-year restricted mean percentage of person-time spent in care, on ART, and virally suppressed among 19 521 women (21...
August 31, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Imran H Iftikhar, Mathew Schimmel, William Bender, Colin Swenson, David Amrol
BACKGROUND: Several new biologics have been studied in patients with eosinophilic asthma with varying degrees of response on clinical outcomes. No head-to-head trial has directly compared the efficacy of these drugs. OBJECTIVE: To synthesize data on the relative efficacy of benralizumab, dupilumab, lebrikizumab, mepolizumab, reslizumab, and tralokinumab using network meta-analysis. DATA SOURCES: We searched PubMed from inception to December 15th, 2017...
October 2018: Lung
You-Cheng Hseu, Geng-Ruei Chang, Jian-You Pan, Peramaiyan Rajendran, Dony Chacko Mathew, Mei-Ling Li, Jiunn-Wang Liao, William Tzu-Liang Chen, Hsin-Ling Yang
Antrodia camphorata (AC) exhibits potential for engendering cell-cycle arrest as well as prompting apoptosis and metastasis inhibition in triple-negative breast cancer (TNBC) cells. We performed the current study to explore the anti-epithelial-to-mesenchymal transition (EMT) properties of fermented AC broth in TNBC cells. Our results illustrated that noncytotoxic concentrations of AC (20-60 μg/ml) reversed the morphological changes (fibroblastic-to-epithelial phenotype) as well as the EMT by upregulating the observed E-cadherin expression...
August 26, 2018: Journal of Cellular Physiology
P Finnegan, M Fitzgerald, D Smit, K Martin, J Mathew, D Varma, A Lim, S Scott, K Williams, Y Kim, B Mitra
BACKGROUND: Complications related to incorrect positioning of tube thoracostomy (TT) have been reported to be as high as 30%. The aim of this study was to assess the feasibility of flexible videoscope guided placement of a pre-loaded chest tube, permitting direct intrapleural visualization and placement (Video-Tube Thoracostomy [V-TT]). METHODS: A prospective, single centre, phase 1 pilot study with a parallel control group was undertaken. The population studied were adult thoracic trauma patients requiring emergency TT who were haemodynamically stable...
August 11, 2018: Injury
Robert A Houze, Lynn A McMurdie, Walter A Petersen, Mathew R Schwaller, William Baccus, Jessica D Lundquist, Clifford F Mass, Bart Nijssen, Steven A Rutledge, David R Hudak, Simone Tanelli, Gerald G Mace, Michael R Poellot, Dennis P Lettenmaier, Joseph P Zagrodnik, Angela K Rowe, Jennifer C DeHart, Luke E Madaus, Hannah C Barnes
OLYMPEX is a comprehensive field campaign to study how precipitation in Pacific storms is modified by passage over coastal mountains.
October 2017: Bulletin of the American Meteorological Society
Basil M Saour, Jeffrey H Wang, Michael P Lavelle, Roy O Mathew, Mandeep S Sidhu, William E Boden, Joseph D Sacco, Eric J Costanzo, Mohammad A Hossain, Tuhsar Vachharanji, Anas Alrefaee, Arif Asif
INTRODUCTION: Reliable markers to predict sudden cardiac death (SCD) in patients with end stage renal disease (ESRD) remain elusive, but echocardiogram (ECG) parameters may help stratify patients. Given their roles as markers for myocardial dispersion especially in high risk populations such as those with Brugada syndrome, we hypothesized that the Tpeak to Tend (TpTe) interval and TpTe/QT are independent risk factors for SCD in ESRD. METHODS: Retrospective chart review was conducted on a cohort of patients with ESRD starting hemodialysis...
August 16, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
Catherine Goudie, Noelle Cullinan, Anita Villani, Natalie Mathews, Kalene van Engelen, David Malkin, Meredith S Irwin, William D Foulkes
BACKGROUND: Neuroblastoma is the most common pediatric extracranial solid tumor. Germline pathogenic variants in ALK and PHOX2B, as well as other cancer predisposition genes, are increasingly implicated in the pathogenesis of neuroblastic tumors. A challenge for clinicians is the identification of children with neuroblastoma who require genetics evaluation for underlying cancer predisposition syndromes (CPS). PROCEDURE: We developed a decisional algorithm (MIPOGG) to identify which patients with neuroblastic tumors have an increased likelihood of an underlying CPS...
August 16, 2018: Pediatric Blood & Cancer
Mathew Geltzeiler, Marnie Bertolet, William Albergotti, John Gleysteen, Brennan Olson, Michael Persky, Neil Gross, Ryan Li, Peter Andersen, Seungwon Kim, Robert L Ferris, Umamaheswar Duvvuri, Daniel Clayburgh
IMPORTANCE: The American Joint Committee on Cancer, 8th edition (AJCC-8) contains a new staging system for human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC). Our study aim was to evaluate the effectiveness of the AJCC-8 relative to the AJCC 7th edition (AJCC-7). MATERIALS AND METHODS: A retrospective chart review was performed on a multi-institutional, prospectively collected dataset from two tertiary referral centers. All patients had HPV+ OPSCC treated primarily with surgery...
September 2018: Oral Oncology
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