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“Mathew williams”

Basil M Saour, Jeffrey H Wang, Michael P Lavelle, Roy O Mathew, Mandeep S Sidhu, William E Boden, Joseph D Sacco, Eric J Costanzo, Mohammad A Hossain, Tuhsar Vachharanji, Anas Alrefaee, Arif Asif
INTRODUCTION: Reliable markers to predict sudden cardiac death (SCD) in patients with end stage renal disease (ESRD) remain elusive, but echocardiogram (ECG) parameters may help stratify patients. Given their roles as markers for myocardial dispersion especially in high risk populations such as those with Brugada syndrome, we hypothesized that the Tpeak to Tend (TpTe) interval and TpTe/QT are independent risk factors for SCD in ESRD. METHODS: Retrospective chart review was conducted on a cohort of patients with ESRD starting hemodialysis...
August 16, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
Catherine Goudie, Noelle Cullinan, Anita Villani, Natalie Mathews, Kalene van Engelen, David Malkin, Meredith S Irwin, William D Foulkes
BACKGROUND: Neuroblastoma is the most common pediatric extracranial solid tumor. Germline pathogenic variants in ALK and PHOX2B, as well as other cancer predisposition genes, are increasingly implicated in the pathogenesis of neuroblastic tumors. A challenge for clinicians is the identification of children with neuroblastoma who require genetics evaluation for underlying cancer predisposition syndromes (CPS). PROCEDURE: We developed a decisional algorithm (MIPOGG) to identify which patients with neuroblastic tumors have an increased likelihood of an underlying CPS...
August 16, 2018: Pediatric Blood & Cancer
Mathew Geltzeiler, Marnie Bertolet, William Albergotti, John Gleysteen, Brennan Olson, Michael Persky, Neil Gross, Ryan Li, Peter Andersen, Seungwon Kim, Robert L Ferris, Umamaheswar Duvvuri, Daniel Clayburgh
IMPORTANCE: The American Joint Committee on Cancer, 8th edition (AJCC-8) contains a new staging system for human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC). Our study aim was to evaluate the effectiveness of the AJCC-8 relative to the AJCC 7th edition (AJCC-7). MATERIALS AND METHODS: A retrospective chart review was performed on a multi-institutional, prospectively collected dataset from two tertiary referral centers. All patients had HPV+ OPSCC treated primarily with surgery...
September 2018: Oral Oncology
Gary Marks, Christine O'Daniels, Cynthia Grossman, Nicole Crepaz, Charles E Rose, Unnati Patel, Michael J Stirratt, Lytt I Gardner, Edward R Cachay, William C Mathews, Mari-Lynn Drainoni, Meg Sullivan, Lucy Bradley-Springer, Marla Corwin, Christopher Gordon, Allan Rodriguez, Shireesha Dhanireddy, Thomas P Giordano
We sought to integrate a brief computer and counseling support intervention into the routine practices of HIV clinics and evaluate effects on patients' viral loads. The project targeted HIV patients in care whose viral loads exceeded 1000 copies/ml at the time of recruitment. Three HIV clinics initiated the intervention immediately, and three other HIV clinics delayed onset for 16 months and served as concurrent controls for evaluating outcomes. The intervention components included a brief computer-based intervention (CBI) focused on antiretroviral therapy adherence; health coaching from project counselors for participants whose viral loads did not improve after doing the CBI; and behavioral screening and palm cards with empowering messages available to all patients at intervention clinics regardless of viral load level...
August 16, 2018: AIDS Care
Euan S Polson, Verena B Kuchler, Christopher Abbosh, Edith M Ross, Ryan K Mathew, Hester A Beard, Bárbara da Silva, Andrew N Holding, Stephane Ballereau, Eulashini Chuntharpursat-Bon, Jennifer Williams, Hollie B S Griffiths, Hao Shao, Anjana Patel, Adam J Davies, Alastair Droop, Paul Chumas, Susan C Short, Mihaela Lorger, Jason E Gestwicki, Lee D Roberts, Robin S Bon, Simon J Allison, Shoutian Zhu, Florian Markowetz, Heiko Wurdak
Pharmacological inhibition of uncontrolled cell growth with small-molecule inhibitors is a potential strategy for treating glioblastoma multiforme (GBM), the most malignant primary brain cancer. We showed that the synthetic small-molecule KHS101 promoted tumor cell death in diverse GBM cell models, independent of their tumor subtype, and without affecting the viability of noncancerous brain cell lines. KHS101 exerted cytotoxic effects by disrupting the mitochondrial chaperone heat shock protein family D member 1 (HSPD1)...
August 15, 2018: Science Translational Medicine
Md Ashrafuzzaman, Zahidul Haque, Basharat Ali, Boby Mathew, Peng Yu, Frank Hochholdinger, Joao Braga de Abreu Neto, Max R McGillen, Hans-Jürgen Ensikat, William J Manning, Michael Frei
Monitoring of ozone damage to crops plays an increasingly important role for the food security of many developing countries. Ethylenediurea (EDU) could be a tool to assess ozone damage to vegetation on field scale, but its physiological mode of action remains unclear. This study investigated mechanisms underlying the ozone-protection effect of EDU in controlled chamber experiments. Ozone sensitive and tolerant rice genotypes were exposed to ozone (108 ppb, 7 h day-1 ) and control conditions. EDU alleviated ozone effects on plant morphology, foliar symptoms, lipid peroxidation and photosynthetic parameters in sensitive genotypes...
August 14, 2018: Plant, Cell & Environment
Jason J Sico, Fitsum Baye, Laura J Myers, John Concato, Jared Ferguson, Eric M Cheng, Farid Jadbabaie, Zhangsheng Yu, Gregory Arling, Alan J Zillich, Mathew J Reeves, Linda S Williams, Dawn M Bravata
Background: American Heart Association/American Stroke Association expert consensus guidelines recommend consideration of cardiac stress testing to screen for occult coronary heart disease (CHD) among patients with ischemic stroke/TIA who have a high-risk Framingham Cardiac Risk Score (FCRS). Whether this guideline is being implemented in routine clinical practice, and the association of its implementation with mortality, is less clear. Methods: Study participants were Veterans with stroke/TIA (n = 11,306) during fiscal year 2011 who presented to a VA Emergency Department or who were admitted...
June 2018: Neurology. Clinical Practice
Jörn A Karhausen, Wenjing Qi, Alan M Smeltz, Yi-Ju Li, Svati H Shah, William E Kraus, Joseph P Mathew, Mihai V Podgoreanu, Miklos D Kertai
INTRODUCTION:  Thrombocytopenia after cardiac surgery independently predicts stroke, acute kidney injury and death. To understand the underlying risks and mechanisms, we analysed genetic variations associated with thrombocytopenia in patients undergoing coronary artery bypass grafting (CABG) surgery. MATERIALS AND METHODS:  Study subjects underwent isolated on-pump CABG surgery at Duke University Medical Center. Post-operative thrombocytopenia was defined as platelet count < 100 × 109 /L...
August 13, 2018: Thrombosis and Haemostasis
Michael S Koeckert, Eugene A Grossi, Patrick F Vining, Ramsey Abdallah, Mathew R Williams, Gary Kalkut, Didier F Loulmet, Elias A Zias, Michael Querijero, Aubrey C Galloway
OBJECTIVE: Medicare's Bundle Payment for Care Improvement(BPCI) Model 2 groups reimbursement for valve surgery into 90-day episodes of care(EOC) which include operative costs, inpatient stay, physician fees, post-acute care, and readmissions up to 90 days post-procedure. We analyzed our BPCI patients' 90-day outcomes to understand the late financial risks and implications of the bundle payment system for valve patients. METHODS: All BPCI valve patients from 10/2013 (start of risk-sharing phase) through 12/2015 were included...
August 10, 2018: Seminars in Thoracic and Cardiovascular Surgery
Andrea Stracciolini, Laura Amar-Dolan, David R Howell, Taylor Alex, Paul Berkner, Noah J Sandstrom, Mark Peluso, Mathew Kurtz, Mannix Rebekah, William P Meehan
BACKGROUND: Female participation in sport has grown substantially over the last 4 decades. OBJECTIVES: We investigated the association between sports participation and (1) later-life health outcomes and (2) later-life quality-of-life (QoL) measures among female college alumni. METHODS: We conducted a cross-sectional study of female alumni between the ages of 40 and 70 years. Participants completed a questionnaire that included QoL measures assessing general health, negative consequences of alcohol use, mental health, and other self-reported health outcomes...
August 8, 2018: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
Steven Higgins, Stephan Heeb, Giordano Rampioni, Mathew P Fletcher, Paul Williams, Miguel Cámara
The Pseudomonas aeruginosa quorum sensing (QS) network plays a key role in the adaptation to environmental changes and the control of virulence factor production in this opportunistic human pathogen. Three interlinked QS systems, namely las, rhl , and pqs , are central to the production of pyocyanin, a phenazine virulence factor which is typically used as phenotypic marker for analysing QS. Pyocyanin production in P. aeruginosa is a complex process involving two almost identical operons termed phzA 1 B 1 C 1 D 1 E 1 F 1 G 1 ( phz1 ) and phzA 2 B 2 C 2 D 2 E 2 F 2 G 2 ( phz2 ), which drive the production of phenazine-1-carboxylic acid (PCA) which is further converted to pyocyanin by two modifying enzymes PhzM and PhzS...
2018: Frontiers in Cellular and Infection Microbiology
Hasan Jilaihawi, Zhen-Gang Zhao, Mathew Williams
No abstract text is available yet for this article.
August 3, 2018: EuroIntervention
Xiaodun Li, Hayley E Francies, Maria Secrier, Juliane Perner, Ahmad Miremadi, Núria Galeano-Dalmau, William J Barendt, Laura Letchford, Genevieve M Leyden, Emma K Goffin, Andrew Barthorpe, Howard Lightfoot, Elisabeth Chen, James Gilbert, Ayesha Noorani, Ginny Devonshire, Lawrence Bower, Amber Grantham, Shona MacRae, Nicola Grehan, David C Wedge, Rebecca C Fitzgerald, Mathew J Garnett
Esophageal adenocarcinoma (EAC) incidence is increasing while 5-year survival rates remain less than 15%. A lack of experimental models has hampered progress. We have generated clinically annotated EAC organoid cultures that recapitulate the morphology, genomic, and transcriptomic landscape of the primary tumor including point mutations, copy number alterations, and mutational signatures. Karyotyping of organoid cultures has confirmed polyclonality reflecting the clonal architecture of the primary tumor. Furthermore, subclones underwent clonal selection associated with driver gene status...
July 30, 2018: Nature Communications
Julia E Hood, Heather Bradley, James P Hughes, Matthew R Golden, Heidi M Crane, Susan E Buskin, Greer A Burkholder, Elvin Geng, Mari M Kitahata, William C Mathews, Richard D Moore, Stephen E Hawes
The estimated burden of chronic disease among people living with HIV (PLWH) varies considerably by data source, due to differences in case definitions, analytic approaches, and underlying patient populations. We evaluated the burden of diabetes (DM) and chronic kidney disease (CKD) in two large data systems that are commonly queried to evaluate health issues affecting HIV care patients: the Medical Monitoring Project (MMP), a nationally representative sample, and the Centers for AIDS Research Network of Integrated Clinical Systems (CNICS), a clinical cohort...
July 27, 2018: AIDS Care
Joseph A Delaney, Robin M Nance, Bridget M Whitney, Frederick L Altice, Xinyuan Dong, Maria Esther Perez Trejo, Mika Matsuzaki, Faye S Taxman, Geetanjali Chander, Irene Kuo, Rob Fredericksen, Lauren N Strand, Joseph J Eron, Elvin Geng, Mari M Kitahata, William C Mathews, Kenneth Mayer, Richard D Moore, Michael S Saag, Sandra Springer, Redonna Chandler, Shoshana Kahana, Heidi M Crane
PURPOSE: Substance use is linked with poor outcomes among people living with HIV (PLWH) and is associated with mental health disorders. This analysis examines the impact of decreasing substance use, even without abstinence, on depressive symptoms among PLWH. METHODS: Data are from PLWH enrolled in the Centers for AIDS Research Network of Integrated Clinical Sites (CNICS) cohort. Participants completed longitudinal assessments of substance use (modified ASSIST) and depressive symptoms (PHQ-9)...
July 19, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Wendy S Tzou, Peter A Rothstein, Michael Cowherd, Matthew M Zipse, Christine Tompkins, Lucas Marzec, Ryan G Aleong, Joseph L Schuller, Paul D Varosy, Ryan T Borne, Jehu Mathew, Alexis Tumolo, Amneet Sandhu, Duy T Nguyen, William H Sauer
INTRODUCTION: Multiple ablations are often necessary to manage ventricular arrhythmias (VAs) in nonischemic cardiomyopathy (NICM) patients. We assessed characteristics and outcomes and role of adjunctive, nonstandard ablation in repeat VA ablation (RAbl) in NICM. METHODS AND RESULTS: Consecutive NICM patients undergoing RAbl were analyzed, with characteristics of the last VA ablations compared between those undergoing 1 versus multiple-repeat ablations (1-RAbl vs...
July 23, 2018: Journal of Cardiovascular Electrophysiology
Eugene A Grossi, Mathew R Williams
No abstract text is available yet for this article.
August 2018: Journal of Thoracic and Cardiovascular Surgery
Hayley E Francies, Andrew Barthorpe, Anne McLaren-Douglas, William J Barendt, Mathew J Garnett
No abstract text is available yet for this article.
March 27, 2018: Methods in Molecular Biology
George Bardsley, Peter Daley-Yates, Amanda Baines, Rodger Kempsford, Mathew Williams, Tony Mallon, Irene Braithwaite, Kylie Riddell, Shashidhar Joshi, Philippe Bareille, Richard Beasley, James Fingleton
BACKGROUND: Fluticasone furoate/Vilanterol trifenatate (FF/VI) is an inhaled corticosteroid/long-acting beta-agonist combination with a prolonged bronchodilator duration of action. We characterised the time-course of onset and offset of airway anti-inflammatory action of FF/VI, as assessed by fraction of exhaled nitric oxide (FeNO), and compared this to the bronchodilator duration of action. METHODS: A single-centre, randomised, double-blind, placebo-controlled, two-period, crossover study was undertaken in 28 steroid-naïve adults with asthma...
July 13, 2018: Respiratory Research
Michael F Tweedle, Haiming Ding, William T Drost, Joshua Dowell, James Spain, Mathew Joseph, Said M Elshafae, Maria-Isabela Menendez, Li Gong, Shankaran Kothandaraman, Wessel P Dirksen, Chadwick L Wright, Robert Bahnson, Michael V Knopp, Thomas J Rosol
BACKGROUND: Ace-1 canine prostate cancer cells grow orthotopically in cyclosporine immunosuppressed laboratory beagles. We previously transfected (human Gastrin-Releasing Peptide Receptor, huGRPr) into Ace-1 cells and demonstrated receptor-targeted NIRF imaging with IR800-G-Abz4-t-BBN, an agonist to huGRPr. Herein, we used the new cell line to develop the first canine prostate cancer model expressing a human growth factor receptor. METHODS: Dogs were immunosuppressed with cyclosporine, azathioprine, prednisolone, and methylprednisolone...
July 11, 2018: Prostate
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