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Elaine Burke, Mary Teeling, Martina Hennessy
INTRODUCTION: A combined academic and clinical training programme for junior doctors in Ireland, the academic track for internship, has recently been launched. The academic track offers newly graduated doctors protected time within the working week to undertake a research project in addition to funding, an academic supervisor, and additional training in research skills. This study seeks to investigate the views of undergraduate medical students. METHODS: The study population was undergraduate medical students at Trinity College Dublin in their penultimate year of study...
October 20, 2018: Irish Journal of Medical Science
Johanna Junker, Valerie Brandt, Brian D Berman, Marie Vidailhet, Emmanuel Roze, Anne Weissbach, Cynthia Comella, Irene A Malaty, Joseph Jankovic, Mark S LeDoux, Alfredo Berardelli, Richard Barbano, Stephen G Reich, Joel S Perlmutter, H A Jinnah, Norbert Brüggemann
OBJECTIVE: To determine predictors of alcohol responsiveness in a large cohort of patients with dystonia. METHODS: A total of 2,159 participants with dystonia were prospectively enrolled in the cross-sectional Dystonia Coalition multicenter study. Patients with secondary, combined, or confirmed genetic dystonia (total n = 164) or unknown alcohol responsiveness (n = 737) were excluded. Patients answered a standardized questionnaire and were clinically examined using a standardized video protocol and the Burke-Fahn-Marsden Dystonia Rating Scale...
October 19, 2018: Neurology
Meghan E Byrne, Marian Tanofsky-Kraff, Nichole M Kelly, Anne Claire Grammer, Manuela Jaramillo, Sarah J Mi, Monika M Stojek, Lisa M Shank, Natasha L Burke, Omni Cassidy, Natasha A Schvey, Sheila M Brady, Andrew P Demidowich, Miranda M Broadney, Susan Z Yanovski, Jack A Yanovski
Objective:  Pediatric loss-of-control (LOC) eating is associated with, and predictive of, gains in adiposity and adverse metabolic outcomes. In addition, some preliminary data suggest that anxiety may exacerbate the relationship of LOC eating with weight and metabolic syndrome (MetS)-related measures. We therefore examined whether anxiety moderated the relationship between LOC eating and body mass index z (BMIz), adiposity, and MetS-related measures in youth. Methods:  A convenience sample of non-treatment-seeking boys and girls of varying weight strata were interviewed to determine the presence of LOC eating and completed a questionnaire assessing trait anxiety...
October 18, 2018: Journal of Pediatric Psychology
Peter Tajti, Iosif Xenogiannis, Ivan Chavez, Mario Gössl, Michael Mooney, Anil Poulose, Paul Sorajja, Jay Traverse, Yale Wang, M Nicholas Burke, Emmanouil S Brilakis
Coronary artery perforations are more likely to occur during percutaneous coronary intervention of complex coronary lesions, such as heavily calcified lesions and chronic total occlusions. Areas covered: Authors provide an update on the management of coronary perforations by performing a critical review of the related, recently published literature. Expert commentary: Meticulous attention to guidewire position and to device selection is critical for minimizing the risk for coronary perforation. If a perforation occurs, following a structured, algorithmic approach can maximize the likelihood of a successful outcome...
October 19, 2018: Expert Review of Cardiovascular Therapy
Jennifer R Seal, Michael R Robinson, James Burke, Marina Bejanian, Michael Coote, Mayssa Attar
PURPOSE: To explore the ocular distribution of bimatoprost after intracameral administration of a biodegradable sustained-release bimatoprost implant (Bimatoprost SR) versus repeated topical administration of bimatoprost 0.03% ophthalmic solution in dogs. Bimatoprost SR and topical bimatoprost 0.03% previously were shown to have similar intraocular pressure-lowering effects in humans in a phase 1/2 clinical trial. METHODS: Twenty-four beagle dogs received either once-daily topical bimatoprost 0...
October 18, 2018: Journal of Ocular Pharmacology and Therapeutics
Crystal R Smit, Rebecca N H de Leeuw, Kirsten E Bevelander, William J Burk, Laura Buijs, Thabo J van Woudenberg, Moniek Buijzen
OBJECTIVE: In this study, we tested an integrated model for why young adolescents consume fruit, vegetables, and water. The model was based on evidence from studies applying three dominant theoretical approaches, including planned behavior, social norms, and intrinsic motivation. METHOD: The integrated model was tested with structural equation modeling using four data-collection waves of the MyMovez Project (MyMovez, 2017) in which 953 young adolescents (53.9% girls; M age = 11...
October 18, 2018: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
Eunji Sim, Suhwan Song, Kieron Burke
We argue that any general mathematical measure of density error, no matter how reasonable, is too arbitrary to be of universal use. However the energy functional itself provides a universal relevant measure of density errors. For the self-consistent density of any Kohn-Sham calculation with an approximate functional, the theory of density corrected DFT provides an accurate, practical estimate of this ideal measure. We show how to estimate the significance of the density-driven error even when exact densities are unavailable...
October 18, 2018: Journal of Physical Chemistry Letters
Jason R Falvey, Michael J Bade, Jeri E Forster, Robert E Burke, Jason M Jennings, Eugene Nuccio, Jennifer E Stevens-Lapsley
BACKGROUND: Home-health-care utilization after total knee arthroplasty (TKA) is increasing. Recent publications have suggested that supervised rehabilitation is not needed to optimize functional recovery after TKA; however, few studies have evaluated patients in home-health-care settings. The objectives of this study were to (1) determine whether physical therapy (PT) utilization is associated with functional improvements for patients in home-health-care settings after TKA and (2) determine which factors are related to utilization of PT...
October 17, 2018: Journal of Bone and Joint Surgery. American Volume
Jeffrey W Tyner, Cristina E Tognon, Daniel Bottomly, Beth Wilmot, Stephen E Kurtz, Samantha L Savage, Nicola Long, Anna Reister Schultz, Elie Traer, Melissa Abel, Anupriya Agarwal, Aurora Blucher, Uma Borate, Jade Bryant, Russell Burke, Amy Carlos, Richie Carpenter, Joseph Carroll, Bill H Chang, Cody Coblentz, Amanda d'Almeida, Rachel Cook, Alexey Danilov, Kim-Hien T Dao, Michie Degnin, Deirdre Devine, James Dibb, David K Edwards, Christopher A Eide, Isabel English, Jason Glover, Rachel Henson, Hibery Ho, Abdusebur Jemal, Kara Johnson, Ryan Johnson, Brian Junio, Andy Kaempf, Jessica Leonard, Chenwei Lin, Selina Qiuying Liu, Pierrette Lo, Marc M Loriaux, Samuel Luty, Tara Macey, Jason MacManiman, Jacqueline Martinez, Motomi Mori, Dylan Nelson, Ceilidh Nichols, Jill Peters, Justin Ramsdill, Angela Rofelty, Robert Schuff, Robert Searles, Erik Segerdell, Rebecca L Smith, Stephen E Spurgeon, Tyler Sweeney, Aashis Thapa, Corinne Visser, Jake Wagner, Kevin Watanabe-Smith, Kristen Werth, Joelle Wolf, Libbey White, Amy Yates, Haijiao Zhang, Christopher R Cogle, Robert H Collins, Denise C Connolly, Michael W Deininger, Leylah Drusbosky, Christopher S Hourigan, Craig T Jordan, Patricia Kropf, Tara L Lin, Micaela E Martinez, Bruno C Medeiros, Rachel R Pallapati, Daniel A Pollyea, Ronan T Swords, Justin M Watts, Scott J Weir, David L Wiest, Ryan M Winters, Shannon K McWeeney, Brian J Druker
The implementation of targeted therapies for acute myeloid leukaemia (AML) has been challenging because of the complex mutational patterns within and across patients as well as a dearth of pharmacologic agents for most mutational events. Here we report initial findings from the Beat AML programme on a cohort of 672 tumour specimens collected from 562 patients. We assessed these specimens using whole-exome sequencing, RNA sequencing and analyses of ex vivo drug sensitivity. Our data reveal mutational events that have not previously been detected in AML...
October 17, 2018: Nature
Shashank Sarvepalli, Carol A Burke, Marc Monachese, Rocio Lopez, Brandie H Leach, Lisa Laguardia, Margaret O'Malley, Matthew F Kalady, James M Church
INTRODUCTION: The timing of prophylactic colorectal surgery in patients with familial adenomatous polyposis (FAP) is based on the immediacy of the colorectal cancer risk. The ability to predict the need for surgery may help patients and their families plan in the context of life events and CRC risk. We created a model to predict the likelihood of surgery within 2 and 5 years of first colonoscopy at our institution. METHODS: A single institution hereditary colorectal syndrome (Cologene™) database was interrogated for all patients with FAP having a deleterious APC mutation...
October 17, 2018: American Journal of Gastroenterology
Rachel Lenzi, Catherine Packer, Kathleen Ridgeway, Troy D Moon, Ann F Green, Lazaro González-Calvo, Holly M Burke
Women First was a combined economic and social empowerment intervention implemented between 2010 and 2015 in Zambézia Province, Mozambique. The intervention was designed to reduce adolescent girls' risk of HIV and gender-based violence, improve school attendance and empower girls. However, perceptions of girls' improved respectfulness also emerged as an unanticipated effect during the programme evaluation. In this paper, we explore emic definitions of respect and girls' good behaviour and perceptions of how the intervention caused improvements in behaviour from the perspective of intervention participants, their heads of household, influential men in their lives, and community members...
October 17, 2018: Culture, Health & Sexuality
Cory M McLaughlin, Minna M Wieck, Erica N Barin, Alyssa Rake, Rita V Burke, Heather B Roesly, L Caulette Young, Todd P Chang, Elizabeth A Cleek, Inge Morton, Catherine J Goodhue, Randall S Burd, Henri R Ford, Jeffrey S Upperman, Aaron R Jensen
PURPOSE: Simulation-based training has the potential to improve team-based care. We hypothesized that implementation of an in situ multidisciplinary simulation-based training program would improve provider confidence in team-based management of severely injured pediatric trauma patients. METHODS: An in situ multidisciplinary pediatric trauma simulation-based training program with structured debriefing was implemented at a free-standing children's hospital. Trauma providers were anonymously surveyed 1 month before (pre-), 1 month after (post-), and 2 years after implementation...
October 15, 2018: Pediatric Surgery International
G Damian Brusko, S Shelby Burks, Michael Y Wang
No abstract text is available yet for this article.
November 1, 2018: Neurosurgery
Willem G van Panhuis, Anne Cross, Donald S Burke
Objective: In 2013, we released Project Tycho, an open-access database comprising 3.6 million counts of infectious disease cases and deaths reported for over a century by public health surveillance in the United States. Our objective is to describe how Project Tycho version 1 (v1) data has been used to create new knowledge and technology and to present improvements made in the newly released version 2.0 (v2). Materials and Methods: We analyzed our user database and conducted online searches to analyze the use of Project Tycho v1 data...
October 15, 2018: Journal of the American Medical Informatics Association: JAMIA
Romuald N Lipcius, Russell P Burke
Restoration efforts with native eastern oyster, Crassostrea virginica, in Chesapeake Bay and elsewhere have been limited by shell availability, necessitating the use of alternative structures as subtidal reefs, yet these have rarely been evaluated quantitatively. We quantified population structure, density, abundance and biomass of eastern oyster and hooked mussel, Ischadium recurvum, on a concrete modular reef (75 m2 surface area over 5 m2 of river bottom) deployed subtidally at 7 m depth in the Rappahannock River, Virginia during October, 2000...
2018: PloS One
Lior M Elkaim, Naif M Alotaibi, Alissa Sigal, Haifa M Alotaibi, Nir Lipsman, Suneil K Kalia, Darcy L Fehlings, Andres M Lozano, George M Ibrahim
AIM: We performed a meta-analysis with individual participant data of deep brain stimulation (DBS) for dystonia in children and young people. METHOD: Three databases (PubMed, Embase, and Web of Science) were queried from January 1999 to August 2017 with no language restrictions to identify case studies and cohort studies reporting on pediatric patients (age ≤21y) with dystonia. The primary outcomes were changes in Burke-Fahn-Marsden (BFM) or Barry-Albright Dystonia Scale scores...
October 15, 2018: Developmental Medicine and Child Neurology
Brandi T Johnson-Weaver, Herman F Staats, A Wesley Burks, Michael D Kulis
Food allergies are a growing public health concern with an estimated 8% of US children affected. Peanut allergies are also on the rise and often do not spontaneously resolve, leaving individuals at-risk for potentially life-threatening anaphylaxis throughout their lifetime. Currently, two forms of peanut immunotherapy, oral immunotherapy (OIT) and epicutaneous immunotherapy (EPIT), are in Phase III clinical trials and have shown promise to induce desensitization in many subjects. However, there are several limitations with OIT and EPIT, such as allergic side effects, daily dosing requirements, and the infrequent outcome of long-term tolerance...
2018: Frontiers in Immunology
Uche F Onyewuchi, Kathy Tomaszewski, Krishna K Upadhya, Priya S Gupta, Natalie Whaley, Anne E Burke, Maria E Trent
The objective of this quality improvement study was to assess the feasibility, acceptability, and impact of integrating long-acting reversible contraceptive (LARC) delivery services into an academic pediatric primary care practice. Adolescent medicine providers in Baltimore, Maryland, were trained in LARC placement with gynecology providers integrated to offer onsite LARC placement and procedural support. Referrals, appointments, and contraceptive method choice/receipt were tabulated. Of 212 individuals referred for LARC consultations, 104 attended appointments...
October 13, 2018: Clinical Pediatrics
Sagarmoy Mandal, Jayashrita Debnath, Bernd Meyer, Nisanth N Nair
Plane wave basis sets offer many advantages in ab initio molecular dynamics due to their efficiency and simplicity. In combination with hybrid density functionals, they become computationally expensive due to the evaluation of the Hartree-Fock exchange energy. The computational cost can be significantly reduced by screening the Kohn-Sham orbital products after localizing the orbitals in real space. However, such a procedure introduces apparent errors in the wavefunctions and nuclear forces resulting in unstable dynamics...
October 14, 2018: Journal of Chemical Physics
Brendan M Browne, Kristian D Stensland, Chintan K Patel, Travis Sullivan, Eric J Burks, David Canes, Jay D Raman, Joshua Warrick, Kimberly M Reiger-Christ
OBJECTIVE: To evaluate microRNA biomarkers for upper tract urothelial carcinoma (UTUC) to improve risk stratification. METHODS: MicroRNA was isolated from 157 radical nephroureterectomy (RNU) specimens from two institutions. The relative expression of miRNA was examined for high grade versus low grade tumors as well as muscle invasive versus non-muscle invasive tumors. Recurrence free survival (RFS) and overall survival (OS) were also stratified using relative expression of specific miRNA...
October 10, 2018: Urology
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