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https://www.readbyqxmd.com/read/30517889/diabetes-sleep-treatment-trial-premise-design-and-methodology
#1
Eileen R Chasens, Charles W Atwood, Lora E Burke, Mary Korytkowski, Robert Stansbury, Patrick J Strollo, Susan M Sereika
The Diabetes Sleep Treatment Trial (DSTT) is a multi-site, double-blinded, randomized, sham-controlled trial. The study objective is to test whether treatment of obstructive sleep apnea (OSA) with continuous positive airway pressure (CPAP) treatment results in improved glycemic control and diabetes self-management behavior compared to participants on a sham-CPAP (sub-therapeutic) device in participants with type 2 diabetes mellitus (T2DM) and co-morbid OSA. The purpose of this paper is to describe the premise for the DSTT, the study design, and the methodology used in this on-going trial...
December 2, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/30517796/combination-of-the-searches-for-pair-produced-vectorlike-partners-of-the-third-generation-quarks-at-sqrt-s-13-tev-with-the-atlas-detector
#2
M Aaboud, G Aad, B Abbott, O Abdinov, B Abeloos, D K Abhayasinghe, S H Abidi, O S AbouZeid, N L Abraham, H Abramowicz, H Abreu, Y Abulaiti, B S Acharya, S Adachi, L Adam, L Adamczyk, J Adelman, M Adersberger, A Adiguzel, T Adye, A A Affolder, Y Afik, C Agheorghiesei, J A Aguilar-Saavedra, F Ahmadov, G Aielli, S Akatsuka, T P A Åkesson, E Akilli, A V Akimov, G L Alberghi, J Albert, P Albicocco, M J Alconada Verzini, S Alderweireldt, M Aleksa, I N Aleksandrov, C Alexa, T Alexopoulos, M Alhroob, B Ali, G Alimonti, J Alison, S P Alkire, C Allaire, B M M Allbrooke, B W Allen, P P Allport, A Aloisio, A Alonso, F Alonso, C Alpigiani, A A Alshehri, M I Alstaty, B Alvarez Gonzalez, D Álvarez Piqueras, M G Alviggi, B T Amadio, Y Amaral Coutinho, A Ambler, L Ambroz, C Amelung, D Amidei, S P Amor Dos Santos, S Amoroso, C S Amrouche, C Anastopoulos, L S Ancu, N Andari, T Andeen, C F Anders, J K Anders, K J Anderson, A Andreazza, V Andrei, C R Anelli, S Angelidakis, I Angelozzi, A Angerami, A V 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Zemaityte, J C Zeng, Q Zeng, O Zenin, D Zerwas, M Zgubič, D F Zhang, D Zhang, F Zhang, G Zhang, G Zhang, H Zhang, J Zhang, L Zhang, L Zhang, M Zhang, P Zhang, R Zhang, R Zhang, X Zhang, Y Zhang, Z Zhang, Y Zhao, Z Zhao, A Zhemchugov, Z Zheng, D Zhong, B Zhou, C Zhou, L Zhou, M S Zhou, M Zhou, N Zhou, Y Zhou, C G Zhu, H L Zhu, H Zhu, J Zhu, Y Zhu, X Zhuang, K Zhukov, V Zhulanov, A Zibell, D Zieminska, N I Zimine, S Zimmermann, Z Zinonos, M Zinser, M Ziolkowski, G Zobernig, A Zoccoli, K Zoch, T G Zorbas, R Zou, M Zur Nedden, L Zwalinski
A combination of the searches for pair-produced vectorlike partners of the top and bottom quarks in various decay channels (T→Zt/Wb/Ht, B→Zb/Wt/Hb) is performed using 36.1  fb^{-1} of pp collision data at sqrt[s]=13  TeV with the ATLAS detector at the Large Hadron Collider. The observed data are found to be in good agreement with the standard model background prediction in all individual searches. Therefore, combined 95% confidence-level upper limits are set on the production cross section for a range of vectorlike quark scenarios, significantly improving upon the reach of the individual searches...
November 23, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/30517793/observation-of-centrality-dependent-acoplanarity-for-muon-pairs-produced-via-two-photon-scattering-in-pb-pb-collisions-at-sqrt-s_-nn-5-02-tev-with-the-atlas-detector
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Zhang, R Zhang, R Zhang, X Zhang, Y Zhang, Z Zhang, P Zhao, X Zhao, Y Zhao, Z Zhao, A Zhemchugov, B Zhou, C Zhou, L Zhou, M S Zhou, M Zhou, N Zhou, Y Zhou, C G Zhu, H L Zhu, H Zhu, J Zhu, Y Zhu, X Zhuang, K Zhukov, V Zhulanov, A Zibell, D Zieminska, N I Zimine, S Zimmermann, Z Zinonos, M Zinser, M Ziolkowski, G Zobernig, A Zoccoli, K Zoch, T G Zorbas, R Zou, M Zur Nedden, L Zwalinski
This Letter presents a measurement of γγ→μ^{+}μ^{-} production in Pb+Pb collisions recorded by the ATLAS detector at the Large Hadron Collider at sqrt[s_{NN}]=5.02  TeV with an integrated luminosity of 0.49  nb^{-1}. The azimuthal angle and transverse momentum correlations between the muons are measured as a function of collision centrality. The muon pairs are produced from γγ through the interaction of the large electromagnetic fields of the nuclei. The contribution from background sources of muon pairs is removed using a template fit method...
November 23, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/30517737/comprehensive-study-of-the-clinical-phenotype-of-germline-bap1-variant-carrying-families-worldwide
#4
Sebastian Walpole, Antonia L Pritchard, Colleen M Cebulla, Robert Pilarski, Meredith Stautberg, Frederick H Davidorf, Arnaud de la Fouchardière, Odile Cabaret, Lisa Golmard, Dominique Stoppa-Lyonnet, Erin Garfield, Ching-Ni Njauw, Mitchell Cheung, Joni A Turunen, Pauliina Repo, Reetta-Stiina Järvinen, Remco van Doorn, Martine J Jager, Gregorius P M Luyten, Marina Marinkovic, Cindy Chau, Miriam Potrony, Veronica Höiom, Hildur Helgadottir, Lorenza Pastorino, William Bruno, Virginia Andreotti, Bruna Dalmasso, Giulia Ciccarese, Paola Queirolo, Luca Mastracci, Karin Wadt, Jens Folke Kiilgaard, Michael R Speicher, Natasha van Poppelen, Emine Kilic, Rana'a T Al-Jamal, Irma Dianzani, Marta Betti, Carsten Bergmann, Sandro Santagata, Sonika Dahiya, Saleem Taibjee, Jo Burke, Nicola Poplawski, Sally J O'Shea, Julia Newton-Bishop, Julian Adlard, David J Adams, Anne-Marie Lane, Ivana Kim, Sonja Klebe, Hilary Racher, J William Harbour, Michael L Nickerson, Rajmohan Murali, Jane M Palmer, Madeleine Howlie, Judith Symmons, Hayley Hamilton, Sunil Warrier, William Glasson, Peter Johansson, Carla Daniela Robles-Espinoza, Raul Ossio, Annelies de Klein, Susana Puig, Paola Ghiorzo, Maartje Nielsen, Tero T Kivelä, Hensin Tsao, Joseph R Testa, Pedram Gerami, Marc-Henri Stern, Brigitte Bressac-de Paillerets, Mohamed H Abdel-Rahman, Nicholas K Hayward
Background: The BRCA1-associated protein-1 (BAP1) tumor predisposition syndrome (BAP1-TPDS) is a hereditary tumor syndrome caused by germline pathogenic variants in BAP1 encoding a tumor suppressor associated with uveal melanoma, mesothelioma, cutaneous melanoma, renal cell carcinoma, and cutaneous BAP1-inactivated melanocytic tumors. However, the full spectrum of tumors associated with the syndrome is yet to be determined. Improved understanding of the BAP1-TPDS is crucial for appropriate clinical management of BAP1 germline variant carriers and their families, including genetic counseling and surveillance for new tumors...
December 4, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/30517044/theta-gamma-cascades-and-running-speed
#5
Alex Sheremet, Jack P Kennedy, Yu Qin, Yuchen Zhou, Sarah D Lovett, Sarah N Burke, Andrew Porter Maurer
Oscillations in the hippocampal LFP at theta and gamma frequencies are prominent during awake-behavior and have demonstrated several behavioral correlates. Both oscillations have been observed to increase in amplitude and frequency as a function of running speed. Previous investigations, however, have examined the relationship between speed and each of these oscillation bands separately. Based on energy cascade models where "... perturbations of slow frequencies cause a cascade of energy dissipation at all frequency scales" (Buzsaki 2006), we hypothesized that cross-frequency interactions between theta and gamma should increase as a function of speed...
December 5, 2018: Journal of Neurophysiology
https://www.readbyqxmd.com/read/30515719/q-twist-analysis-to-assess-benefit-risk-of-pembrolizumab-in-patients-with-pd-l1-positive-advanced-or-metastatic-non-small-cell-lung-cancer
#6
Min Huang, M Catherine Pietanza, Ayman Samkari, James Pellissier, Thomas Burke, Sheenu Chandwani, Fansen Kong, A Simon Pickard
OBJECTIVES: Pembrolizumab monotherapy showed significantly longer overall survival and fewer treatment-related adverse events compared to chemotherapy in patients with advanced or metastatic non-small cell lung cancer (NSCLC) with programmed death ligand-1 (PD-L1)-positive tumors in the first-line setting in KEYNOTE (KN)-024 and in those previously treated in KN010. The objective of this analysis was to assess the benefit-risk of pembrolizumab in terms of quality-adjusted survival amongst patients in these trials...
December 4, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/30515447/neurostimulation-for-functional-neurological-disorder-evaluating-longitudinal-neurophysiology
#7
Matthew J Burke, Reina Isayama, Gaayathiri Jegatheeswaran, Carolyn Gunraj, Anthony Feinstein, Anthony E Lang, Robert Chen
No abstract text is available yet for this article.
September 2018: Movement Disorders Clinical Practice
https://www.readbyqxmd.com/read/30513811/perceived-family-functioning-in-relation-to-energy-intake-in-adolescent-girls-with-loss-of-control-eating
#8
Manuela Jaramillo, Natasha L Burke, Lauren B Shomaker, Sheila M Brady, Merel Kozlosky, Jack A Yanovski, Marian Tanofsky-Kraff
Family functioning is hypothesized to influence the development, maintenance, and treatment of obesity and eating disorders. However, there are limited data examining family functioning in relation to energy intake in the laboratory among youth at high-risk for eating disorders and excess weight gain. Therefore, we examined the relationship between perceived family functioning and energy intake during a laboratory test meal designed to model a binge episode. We performed hierarchical multiple regression analyses among 108 adolescent girls in an excess weight gain prevention trial...
December 2, 2018: Nutrients
https://www.readbyqxmd.com/read/30511082/phase-behavior-of-main-chain-liquid-crystalline-polymer-networks-synthesized-by-alkyne-azide-cycloaddition-chemistry
#9
Yongjian Wang, Kelly A Burke
Liquid crystalline polymer networks (LCNs) couple polymer chain organization to molecular ordering, the switching of which has been shown to impart stimuli-responsive properties, including actuation and one-way shape memory, to the networks. While LCNs have long been proposed as artificial muscles, recent reports have also suggested potential as dynamic biomaterial substrates. In contrast to many existing LCNs synthesized using hydrophobic spacers, this work investigates networks synthesized using more hydrophilic spacers to promote interaction with water...
December 4, 2018: Soft Matter
https://www.readbyqxmd.com/read/30509405/the-american-academy-of-nursing-on-policy-proposed-healthcare-policy-changes-threaten-women-s-health
#10
Carol F Roye, Versie Johnson-Mallard, Pam Burke, Ivy M Alexander, Diana Taylor, Cindy Smith Greenberg, Kim Czubaruk
No abstract text is available yet for this article.
November 2018: Nursing Outlook
https://www.readbyqxmd.com/read/30508739/in-vitro-effect-of-oxidized-and-reduced-glutathione-peptides-on-angiotensin-converting-enzyme-purified-from-human-plasma
#11
Zehra Basi, Vedat Turkoglu
Angiotensin converting enzyme (ACE, peptidyldipeptidase A, EC 3.4.15.1) plays an important role in the regulation of blood pressure. In this study, ACE was purified from human plasma by affinity chromatography in single step. The enzyme purified in 5367-fold from human plasma and specific activity was found to be 1208 EU/mg protein. The purity and molecular weight of ACE were determined by SDS-PAGE, which indicated two bands at around 60 kDa and 70 kDa on the gel. Effect of oxidized glutathione (GSSG) peptide and reduced glutathione (GSH) peptide on purified ACE activity were also investigated in which lisinopril was used as reference inhibitor...
November 19, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/30508130/unpacking-the-black-box-of-lay-health-worker-processes-in-a-us-based-intervention
#12
Nancy J Burke, Kristine Phung, Filmer Yu, Ching Wong, Khanh Le, Isabel Nguyen, Long Nguyen, Alice Guan, Tung T Nguyen, Janice Y Tsoh
Prior studies have supported the effectiveness of the use of Lay Health Workers (LHWs) as an intervention model for managing chronic health conditions, yet few have documented the mechanisms that underlie the effectiveness of the interventions. This study provides a first look into how LHWs delivered a family-based intervention and the challenges encountered. We utilize observation data from LHW-led educational sessions delivered as part of a randomized controlled trial (RCT) designed to test a LHW outreach family-based intervention to promote smoking cessation among Vietnamese American smokers...
December 1, 2018: Health Promotion International
https://www.readbyqxmd.com/read/30508028/association-of-pallidal-neurostimulation-and-outcome-predictors-with-x-linked-dystonia-parkinsonism
#13
Norbert Brüggemann, Aloysius Domingo, Dirk Rasche, Christian K E Moll, Raymond L Rosales, Roland Dominic G Jamora, Henrike Hanssen, Alexander Münchau, Julia Graf, Anne Weissbach, Vera Tadic, Cid C Diesta, Jens Volkmann, Andrea Kühn, Thomas F Münte, Volker Tronnier, Christine Klein
Importance: Anecdotal evidence suggests that deep brain stimulation (DBS) of the internal globus pallidus (GPi) is effective in ameliorating dystonia in X-linked dystonia parkinsonism (XDP), a disease that is usually refractive to medical therapy. Objective: To determine the efficacy of GPi-DBS in a cohort of patients with XDP in a prospective study and identify predictors of postoperative outcomes. Design, Setting, and Participants: This observational prospective cohort study enrolled patients in February 2013 and was completed in December 2014...
December 3, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/30507899/robot-assisted-gait-training-effectively-improved-lateropulsion-in-subacute-stroke-patients-a-single-blinded-randomized-controlled-trial
#14
Na R Yun, Min C Joo, Seungchan Kim, Min-Su Kim
BACKGROUND: Some stroke patients are known to use nonparetic extremities to push toward the paretic side, a movement known as lateropulsion. Lateropulsion impairs postural balance and interferes with rehabilitation. AIM: The aim of the present study was to investigate the effect of robot-assisted gait training (RAGT) on recovery from lateropulsion compared with conventional physical therapy (CPT). DESIGN: This was a single-blinded, randomized controlled trial...
December 3, 2018: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/30507257/nutrition-for-travel-from-jetlag-to-catering
#15
Shona L Halson, Louise M Burke, Jeni Pearce
Domestic and international travel represents a regular challenge to high performance track and field athletes, particularly when associated with the pressure of competition or the need to support specialized training (e.g. altitude or heat adaptation). Jetlag is a challenge for transmeridian travelers while fatigue and alterations to gastrointestinal comfort are associated with many types of long haul travel. Planning food and fluid intake that is appropriate to the travel itinerary may help to reduce problems...
December 3, 2018: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/30506744/alcohol-and-ideal-cardiovascular-health-the-multi-ethnic-study-of-atherosclerosis
#16
Oluseye Ogunmoroti, Olatokunbo Osibogun, Robyn L McClelland, Gregory L Burke, Khurram Nasir, Erin D Michos
BACKGROUND: Alcohol consumption is associated with cardiovascular disease (CVD), with moderate drinkers having decreased CVD risk compared to non- and heavy drinkers. However, whether alcohol consumption is associated with ideal cardiovascular health (CVH), assessed by the AHA Life's Simple 7 (LS7) metrics, and whether associations differ by sex, is uncertain. HYPOTHESIS: Heavy alcohol consumption is associated with worse CVH METHODS: We explored associations between alcohol consumption and CVH in a multi-ethnic population including 6,506 participants free of CVD, aged 45-84 years...
December 2, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/30504514/outcomes-of-extracorporeal-membrane-oxygenation-support-for-complex-high-risk-elective-percutaneous-coronary-interventions-a-single-center-experience-and-review-of-the-literature
#17
Arslan Shaukat, Katarzyna Hryniewicz-Czeneszew, Benjamin Sun, Karol Mudy, Kelly Wilson, Peter Tajti, Larissa Stanberry, Ross Garberich, Yader Sandoval, M Nicholas Burke, Ivan Chavez, Mario Gössl, Timothy Henry, Daniel Lips, Michael Mooney, Anil Poulose, Paul Sorajja, Jay Traverse, Yale Wang, Steven Bradley, Emmanouil S Brilakis
OBJECTIVES: Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is most commonly used in patients with cardiac arrest and cardiogenic shock. There are limited data on the use of VA-ECMO for elective, high-risk percutaneous coronary intervention (PCI). We examined the in-hospital and mid-term clinical outcomes in patients undergoing complex, high-risk PCI with VA-ECMO support. METHODS: . We conducted a retrospective review of ECMO-supported elective high-risk PCIs performed at our institution between May 2012 and May 2017...
December 2018: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/30503744/balloons-are-not-for-angioplasty-alone-a-novel-occlusion-technique-for-stroke-prevention
#18
EDITORIAL
Christopher R Burke, Pavan Atluri
No abstract text is available yet for this article.
November 2, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/30502886/building-mental-health-and-caring-for-vulnerable-children-increasing-prevention-access-and-equity
#19
Kathleen R Delaney, Pamela Burke, Janiece DeSocio, Cindy Smith Greenberg, Daryl Sharp
No abstract text is available yet for this article.
November 2018: Nursing Outlook
https://www.readbyqxmd.com/read/30501288/erratum-correlation-electron-cyclotron-emission-diagnostic-and-improved-calculation-of-turbulent-temperature-fluctuation-levels-on-asdex-upgrade-rev-sci-instrum-89-053503-2018
#20
A J Creely, S J Freethy, W M Burke, G D Conway, R Leccacorvi, W C Parkin, D R Terry, A E White
No abstract text is available yet for this article.
November 2018: Review of Scientific Instruments
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