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https://www.readbyqxmd.com/read/30338413/early-canakinumab-therapy-for-the-sensorineural-deafness-in-a-family-with-muckle-wells-syndrome-due-to-a-novel-mutation-of-nlrp3-gene
#1
Yasunori Iida, Hiroyuki Wakiguchi, Fumiko Okazaki, Tamaki Nakamura, Hiroki Yasudo, Makoto Kubo, Kazuma Sugahara, Hiroshi Yamashita, Yutaka Suehiro, Naoko Okayama, Kunio Hashimoto, Naoki Iwamoto, Atsushi Kawakami, Yoshiharu Aoki, Hidetoshi Takada, Shouichi Ohga, Shunji Hasegawa
Cryopyrin-associated periodic syndrome (CAPS) is one of the autoinflammatory disorders caused by mutations in NLRP3 gene. The over-production of interleukin (IL)-1β induced by NLRP3 gene mutations plays an important role in the pathophysiology of CAPS. We diagnosed 3 patients with CAPS, who were lineal family members having a novel mutation of NLRP3 gene. The objective of this report is to compare the characteristics of symptoms and differences in the therapeutic responses of them, who had the same mutation...
October 18, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/30338086/cardiac-arrest-caused-by-diphenhydramine-overdose
#2
Tomoya Nishino, Shinjirou Wakai, Hiromichi Aoki, Sadaki Inokuchi
Case: A 45-year-old man presented to our emergency department with disturbance of consciousness; he had mentioned to his family earlier about a drug overdose. When first responders arrived, he suffered cardiac arrest. Cardiac arrest due to drug overdose was diagnosed.The patient was supported with venoarterial extracorporeal membrane oxygenation. Arterial blood gas showed mixed acidosis, and electrocardiogram showed junctional rhythm and complete right bundle branch block. Outcome: The patient's blood pressure gradually decreased, and he died on the third day of hospitalization...
October 2018: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/30338080/impact-of-emergency-physicians-competent-in-severe-trauma-management-surgical-techniques-and-interventional-radiology-on-trauma-management
#3
Hiroyuki Otsuka, Toshiki Sato, Keiji Sakurai, Hiromichi Aoki, Takeshi Yamagiwa, Shinichi Iizuka, Sadaki Inokuchi
Aim: Despite recent advancements in trauma management following introduction of interventional radiology (IVR) and damage-control strategies, challenges remain regarding optimal use of resources for severe trauma. Methods: In October 2014, we implemented a trauma management system comprising emergency physicians competent in severe trauma management, surgical techniques, and IVR. To evaluate this system, of 5,899 trauma patients admitted to our hospital from January 2011 to January 2018, we selected 107 patients with severe trauma (injury severity score ≥ 16) who presented with persistent hypotension (two or more systolic blood pressure measurements <90 mmHg), regardless of primary resuscitation...
October 2018: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/30336984/%C3%AE-tocopherol-promotes-thermogenic-gene-expression-via-pgc-1%C3%AE-upregulation-in-3t3-l1-cells
#4
Rieko Tanaka-Yachi, Masato Shirasaki, Rena Otsu, Chie Takahashi-Muto, Hideki Inoue, Yoshinori Aoki, Taisuke Koike, Chikako Kiyose
Activation of thermogenic adipocytes (brown and beige) has been considered an attractive target for weight loss and treatment of metabolic disease. Peroxisome proliferator-activated receptor γ co-activator-1 α (PGC1-α) is a master regulator of thermogenic gene expression in thermogenic adipocytes. We previously reported that α-tocopherol upregulated PGC-1α gene expression and promoted thermogenic adipocyte differentiation in mammalian adipocytes. In this study, we investigated the effects of the vitamin E analogs (α-, γ- and δ-tocopherol) on PGC-1α and uncoupling protein 1 (UCP1) gene expression in 3T3-L1 cells...
October 15, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/30335749/resveratrol-enhances-the-clearance-of-mitochondrial-damage-by-vitrification-and-improves-the-development-of-vitrified-warmed-bovine-embryos
#5
Tomotaka Hara, Airi Kin, Sogo Aoki, Shinsuke Nakamura, Koumei Shirasuna, Takehito Kuwayama, Hisataka Iwata
The present study investigated the vitrification-induced deterioration of mitochondrial functions that may reduce the developmental ability of post-warming bovine embryos. In addition, the effect of supplementation of the culture medium with resveratrol on the mitochondrial functions and post-warming embryonic development was examined. Two days after in vitro fertilization, embryos with 8-12 cells (referred to hereafter as 8-cell embryos) were vitrified and warmed, followed by in vitro incubation for 5 days in a culture medium containing either the vehicle or 0...
2018: PloS One
https://www.readbyqxmd.com/read/30334024/modification-of-amine-cured-epoxy-resins-by-boronic-acids-based-on-their-reactivity-with-intrinsic-diethanolamine-units
#6
Yumiko Ito, Jumpei Kida, Daisuke Aoki, Hideyuki Otsuka
Amine-cured epoxy polymers were modified after curing, exploiting the reactivity of their intrinsic diethanolamine (DEA) units toward boronic acids. The condensation of DEA units with various boronic acids resulted in changes in the thermal, mechanical, and optical properties of the original amine-cured epoxy polymers.
October 18, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/30333487/integrated-extracellular-microrna-profiling-for-ovarian-cancer-screening
#7
Akira Yokoi, Juntaro Matsuzaki, Yusuke Yamamoto, Yutaka Yoneoka, Kenta Takahashi, Hanako Shimizu, Takashi Uehara, Mitsuya Ishikawa, Shun-Ichi Ikeda, Takumi Sonoda, Junpei Kawauchi, Satoko Takizawa, Yoshiaki Aoki, Shumpei Niida, Hiromi Sakamoto, Ken Kato, Tomoyasu Kato, Takahiro Ochiya
A major obstacle to improving prognoses in ovarian cancer is the lack of effective screening methods for early detection. Circulating microRNAs (miRNAs) have been recognized as promising biomarkers that could lead to clinical applications. Here, to develop an optimal detection method, we use microarrays to obtain comprehensive miRNA profiles from 4046 serum samples, including 428 patients with ovarian tumors. A diagnostic model based on expression levels of ten miRNAs is constructed in the discovery set. Validation in an independent cohort reveals that the model is very accurate (sensitivity, 0...
October 17, 2018: Nature Communications
https://www.readbyqxmd.com/read/30333391/clinical-diversity-in-patients-with-anderson-fabry-disease-with-the-r301q-mutation
#8
Saori Yamamoto, Tasuku Nagasawa, Koichiro Sugimura, Atuhiro Kanno, Shunsuke Tatebe, Tatsuo Aoki, Haruka Sato, Katsuya Kozu, Ryo Konno, Kotaro Nochioka, Kimio Sato, Hiroaki Shimokawa
Anderson-Fabry disease (AFD) is a rare X-linked disorder caused by deficient activity of the lysosomal enzyme α-galactosidase A (α-GAL A). We herein report 10 cases of AFD in 5 families (3 men and 7 women) that were found to have a specific common mutation in R301Q (G-to-A transition in exon 6 [codon 301] resulting in the replacement of a glutamine with an arginine residue). We evaluated their clinical characteristics, residual enzymatic activity, and plasma concentrations of globotriaosylsphingosine (Lyso-Gb3)...
October 17, 2018: Internal Medicine
https://www.readbyqxmd.com/read/30324711/evaluation-of-bone-healing-following-er-yag-laser-ablation-in-rat-calvaria-compared-with-bur-drilling
#9
Yujin Ohsugi, Akira Aoki, Koji Mizutani, Sayaka Katagiri, Motohiro Komaki, Masahiro Noda, Toru Takagi, Sho Kakizaki, Walter Meinzer, Yuichi Izumi
The Er:YAG laser is currently used for bone ablation. However, the effect of Er:YAG laser irradiation on bone healing remains unclear. The aim of this study was to investigate bone healing following ablation by laser irradiation as compared with bur drilling. Rat calvarial bone was ablated using Er:YAG laser or bur with water coolant. Er:YAG laser effectively ablated bone without major thermal changes. In-vivo micro-CT analysis revealed that laser irradiation showed significantly higher bone repair ratios than bur drilling...
October 15, 2018: Journal of Biophotonics
https://www.readbyqxmd.com/read/30323595/different-aggregation-and-shape-characteristics-of-carbon-materials-affect-biological-responses-in-raw264-cells
#10
Chika Kuroda, Katsuya Ueda, Hisao Haniu, Haruka Ishida, Satomi Okano, Takashi Takizawa, Atsushi Sobajima, Takayuki Kamanaka, Kazushige Yoshida, Masanori Okamoto, Tamotsu Tsukahara, Yoshikazu Matsuda, Kaoru Aoki, Hiroyuki Kato, Naoto Saito
Introduction: Carbon nanotubes (CNTs) have various shapes, including needle-like shapes and curled shapes, and the cytotoxicity and carcinogenicity of CNTs differ depending on their shapes and surface modifications. However, the biological responses induced by CNTs and related mechanisms according to the dispersion state of CNTs have not been extensively studied. Materials and methods: We prepared multiwalled CNTs (MWCNTs) showing different dispersions and evaluated these MWCNTs in RAW264 cells to determine cytotoxicity, cellular uptake, and immune responses...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/30320616/comparison-of-pixel-values-of-maxillary-sinus-grafts-and-adjacent-native-bone-with-cone-beam-computed-tomography
#11
Danielle Ayumi Nishimura, Eduardo Massaharu Aoki, Reinaldo Abdala Júnior, Emiko Saito Arita, Otavio Henrique Pinhata-Baptista, Ricardo Yudi Tateno, Luciana Correa, Arthur Rodriguez Gonzalez Cortes
PURPOSE: Pixel values from cone-beam computed tomography (CBCT) are proportional to bone density. This study aimed to correlate and compare pixel values of healed maxillary sinus grafts and adjacent native bone (NB). MATERIAL AND METHODS: This study was conducted on CBCT scan patients referred for maxillary sinus floor augmentation with biphasic calcium phosphate (n = 31). Graft height and width measurements were performed. In addition, mean pixel values were calculated in 3 different regions: NB, sinus graft close to NB (CNB), and sinus graft far from NB (FNB)...
October 12, 2018: Implant Dentistry
https://www.readbyqxmd.com/read/30319049/diabetes-mellitus-inhibits-complete-recanalization-in-patients-with-middle-cerebral-artery-occlusion
#12
Junya Aoki, Kazumi Kimura, Naomi Morita, Masafumi Harada, Shinji Nagahiro
METHODS: This was a retrospective cohort study. Data from 165 patients, with middle cerebral occlusion before t-PA therapy (from the YAMATO study databank), were retrospectively evaluated. Patients were classified into diabetic (D) or non-diabetic (ND) groups based on the history of diabetes mellitus (DM) or hemoglobin A1c levels of ≥ 6.5%. Arterial recanalization was assessed using magnetic resonance angiography or digital subtraction angiography at 2 points: 1) early recanalization, within 2 h; 2) delayed complete recanalization at 24 h...
October 15, 2018: Neurological Research
https://www.readbyqxmd.com/read/30317021/a-case-of-monoclonal-gammopathy-of-undetermined-significance-with-abnormal-low-levels-of-plasma-glycated-albumin-by-m-protein
#13
Noriko Kuramoto, Tatsuya Wakahara, Yuichi Tamagawa, Takahiro Uchino, Masahiro Koseto, Manabu Kawakami, Michio Otsuki, Yoshimasa Aoki, Midori Ishibashi, Soji Kasayama, Satoru Sumitani, Masafumi Koga
BACKGROUND: It is known that an immunoglobulin abnormality affects various clinical laboratory measurements and leads to abnormal values. We experienced a case of monoclonal gammopathy of undetermined significance (MGUS) showing a falsely low plasma glycated albumin (GA) level. CASE REPORT: The patient was a 75-y-old male who visited our hospital for thrombocytosis identified during a medical checkup. Based on further examinations, he was diagnosed with MGUS (IgM-κ type)...
October 11, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/30311367/effect-of-switching-from-pioglitazone-to-the-sglt2-inhibitor-dapagliflozin-on-body-weight-and-metabolism-related-factors-in-patients-with-type-2-diabetes-mellitus-an-open-label-prospective-randomized-parallel-group-comparison-trial
#14
Kyu Yon G Cho, Akinobu Nakamura, Kazuno Omori, Takahiro Takase, Aika Miya, Naoki Manda, Yoshio Kurihara, Shin Aoki, Tatsuya Atsumi, Hideaki Miyoshi
The effects of dapagliflozin and pioglitazone on body weight and glycemic control were compared in patients with type 2 diabetes mellitus. Seventy-one patients on pioglitazone (PIO) were either switched to dapagliflozin (DAP, n = 36) at 5 mg per day or continued on PIO (n = 35). Primary endpoints were superiority of weight loss and non-inferiority of HbA1c level after 24 weeks with DAP. Body weight decrease was greater with DAP than with PIO (75.3 ± 14.9 to 71.3 ± 15.1 kg vs. 74.7 ± 13.8 to 75.2 ± 13.9 kg; p < 0...
October 12, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/30310970/clinical-and-in-vitro-studies-of-the-correlation-between-mgmt-and-the-effect-of-streptozocin-in-pancreatic-net
#15
Susumu Hijioka, Keiichiro Sakuma, Masahiro Aoki, Nobumasa Mizuno, Takamichi Kuwahara, Nozomi Okuno, Kazuo Hara, Yasushi Yatabe
PURPOSE: This study aimed to determine the correlation between DNA repair enzyme O6-methylguanine DNA methyltransferase (MGMT) status and the response to streptozocin in advanced well-differentiated pancreatic neuroendocrine tumors (WD panNETs). METHODS: To test the hypothesis that MGMT deficiency was required for an alkylating drug response, we retrospectively reviewed the response of 13 patients with WD panNETs to alkylating agents in relation to MGMT status. We also studied MGMT expression in streptozocin resistance using panNET cell lines...
October 11, 2018: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/30309765/feasibility-of-dynamic-myocardial-ct-perfusion-using-single-source-64-row-ct
#16
Nobuo Tomizawa, Shengpu Chou, Yusuke Fujino, Masaru Kamitani, Kodai Yamamoto, Shinichi Inoh, Takeshi Nojo, Kanako K Kumamaru, Shigeki Aoki, Sunao Nakamura
BACKGROUND: Dynamic myocardial computed tomography perfusion (CTP) is an emerging technique to diagnose significant coronary stenosis. However, this procedure has not been reported using single-source 64-row CT. OBJECTIVE: To investigate the radiation dose and the diagnostic performance of dynamic CTP to diagnose significant stenosis by catheter exam. METHODS: We prospectively included 165 patients who underwent CTP exam under adenosine stress using a single-source 64-row CT...
October 6, 2018: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/30308425/a-case-of-obstructive-jaundice-due-to-early-carcinoma-of-the-cystic-duct-protruding-into-the-common-bile-duct
#17
Yuhki Sakuraoka, Takashi Suzuki, Genki Tanaka, Takayuki Shimizu, Takayuki Shiraki, Park Kyongha, Shozo Mori, Yukihiro Iso, Masato Kato, Taku Aoki, Keiichi Kubota, Hidetsugu Yamagishi
INTRODUCTION: Cystic duct carcinoma is a rare disease, and only 33 cases reported worldwide have completely fulfilled the criteria first established by Farrar in 1951. Here we describe an extremely rare case of early cystic duct carcinoma that fulfilled the Farrar criteria, the papillary tumour protruding into the common bile duct, leading to obstructive jaundice. CASE PRESENTATION: A 76-year-old man visited a clinic with icteric conjunctivae, and was referred to our hospital for investigation of suspected obstructive jaundice...
October 4, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/30306584/cancer-of-the-cervix-uteri
#18
Neerja Bhatla, Daisuke Aoki, Daya Nand Sharma, Rengaswamy Sankaranarayanan
Since the publication of the last FIGO Cancer Report there have been giant strides in the global effort to reduce the burden of cervical cancer, with WHO announcing a call for elimination. In over 80 countries, including LMICs, HPV vaccination is now included in the national program. Screening has also seen major advances with implementation of HPV testing on a larger scale. However, these interventions will take a few years to show their impact. Meanwhile, over half a million new cases are added each year...
October 2018: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/30305982/fetal-congenital-peripheral-bronchial-atresia-diagnosed-by-magnetic-resonance-imaging-two-case-reports
#19
Mitsuru Kozaki, Yuko Iraha, Hitoshi Masamoto, Hayase Nitta, Yukiko Chinen, Tadatsugu Kinjo, Keiko Mekaru, Yoichi Aoki
Two types of congenital bronchial atresia (proximal and peripheral) have been classified. We report two cases of peripheral bronchial atresia diagnosed by prenatal ultrasonography (US) and magnetic resonance imaging (MRI). Evaluating an enlarged lung mass that is homogeneously hyperechoic on US and hyperintense on T2-weighted MRI can help in determining whether bronchial atresia is present. Proximal type is suggested when a dilated main bronchus is observed as a tubule structure of an involved lung hilum. In our cases, T2-weighted MRI revealed homogeneously hyperintense lung lesion with decreased signal intensity of adjacent lobe, flattening diaphragm, and mediastinal shift...
October 2018: American Journal of Perinatology Reports
https://www.readbyqxmd.com/read/30305944/electrical-disorders-in-atrial-septal-defect-genetics-and-heritability
#20
REVIEW
Hisaaki Aoki, Minoru Horie
Atrial septal defect (ASD) is one of the most common types of congenital heart diseases (CHDs). Most ASDs occur sporadically, but some are inherited and associated with cardiac conduction defects such as atrioventricular block (AVB) or bundle branch block. Mutations in genes encoding transcription factor gene TBX5 and NKX2-5 , were found in Holt-Oram syndrome (HOS) and ASD with atrioventricular (AV) conduction defects, respectively. HOS is characterized by upper limb anomaly in addition to ASD and AVB (heart-hand syndrome)...
September 2018: Journal of Thoracic Disease
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