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Lucas S A Pereira, Sabrina A Camacho, Antonio A Malfatti-Gasperini, Karen Jochelavicius, Thatyane M Nobre, Osvaldo N Oliveira, Pedro H B Aoki
Photodynamic therapy (PDT) efficiency depends on many factors including the incorporation of the photosensitizer (PS) in cell membranes and possible lipid hydroperoxidation. In this study, we show that hydroperoxidation may be photoinduced when eosin Y is incorporated into Langmuir monolayers that serve as cell membrane models. This occurs for Langmuir monolayers of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) and 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC), which have unsaturation in their hydrophobic chains...
August 6, 2018: Colloids and Surfaces. B, Biointerfaces
Azusa Kondoh, Akio Iino, Sho Ishikawa, Takuma Aoki, Masahiro Terada
An efficient method for the synthesis of polysubstituted pyrroles was established based on the [3+2] cycloaddition strategy utilizing the [1,2]-phospha-Brook rearrangement under Brønsted base catalysis. The less-explored approach of the [3+2] cycloaddition, i.e., the reaction of a C3 subunit with imines, was successfully achieved by making use of newly designed C3 subunits containing the requisite umpolung. The two-step [3+2] cycloaddition involves the catalytic generation of an α-oxygenated propargyl anion through the [1,2]-phospha-Brook rearrangement followed by γ-addition to the imine under Brønsted base catalysis and the subsequent intramolecular cyclization mediated by Au catalyst or a halogenation reagent to afford polysubstituted pyrroles having a variety of substituents in a positional selective manner...
August 16, 2018: Chemistry: a European Journal
Takayuki Aoki, Miyuki Kudo, Maho Endo, Yuka Nakayama, Akiyuki Amano, Mariko Naito, Yoshihide Ota
PURPOSE: Perioperative oral care is effective for the prevention and reduction of complications following surgery. However, oral cancer patients' oral health is often poor. During hospitalization, oral cancer patients frequently receive oral care from ward nurses as well as professional oral care from dental hygienists. Maintenance of good oral hygiene in these patients ideally requires cooperation between nurses and dental hygienists. Consequently, communication tools used to share information about the status of patients' oral health are needed...
August 15, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Ai Takeyama, Yasuo Nagata, Bungo Shirouchi, Chika Nonaka, Hiromu Aoki, Tsubasa Haraguchi, Masao Sato, Kei Tamaya, Hideto Yamamoto, Kazunari Tanaka
Accumulation of abdominal fat triggers metabolic syndrome, which is a cluster of metabolic abnormalities, such as dyslipidemia, glucose intolerance, insulin resistance or hyperinsulinemia, and hypertension, that leads to the development of diabetes and cardiovascular disease. Mushrooms have been used as a foodstuff and folk medicine worldwide. Among these mushrooms, Sparassis crispa (SC) is a relatively newly cultivated edible and medicinal mushroom, which has been reported to have anti-diabetic and anti-hypertensive properties...
August 14, 2018: Journal of Oleo Science
Nobuo Watanabe, Kirill Kryukov, So Nakagawa, Junko S Takeuchi, Meiko Takeshita, Yukiko Kirimura, Satomi Mitsuhashi, Toru Ishihara, Hiromichi Aoki, Sadaki Inokuchi, Tadashi Imanishi, Shigeaki Inoue
Prompt identification of causative pathogenic bacteria is imperative for the treatment of patients suffering from infectious diseases, including sepsis and pneumonia. However, current culture-based methodologies have several drawbacks including their limitation of use to culturable bacterial species. To circumvent these problems, we attempted to detect bacterial DNA in blood using next-generation DNA sequencing (NGS) technology. We conducted metagenomic and 16S ribosomal RNA (rRNA) gene amplicon sequencing of DNA extracted from bacteria-spiked blood using an Ion Personal Genome Machine...
2018: PloS One
Olga Kyrchanova, Amina Kurbidaeva, Marat Sabirov, Nikolay Postika, Daniel Wolle, Tsutomu Aoki, Oksana Maksimenko, Vladic Mogila, Paul Schedl, Pavel Georgiev
Expression of the three bithorax complex homeotic genes is orchestrated by nine parasegment-specific regulatory domains. Autonomy of each domain is conferred by boundary elements (insulators). Here, we have used an in situ replacement strategy to reanalyze the sequences required for the functioning of one of the best-characterized fly boundaries, Fab-7. It was initially identified by a deletion, Fab-71, that transformed parasegment (PS) 11 into a duplicate copy of PS12. Fab-71 deleted four nuclease hypersensitive sites, HS*, HS1, HS2, and HS3, located between the iab-6 and iab-7 regulatory domains...
August 15, 2018: PLoS Genetics
Masamitsu Yanada, Masayoshi Masuko, Jinichi Mori, Jun Aoki, Shohei Mizuno, Takahiro Fukuda, Kazuhiko Kakihana, Yukiyasu Ozawa, Shuichi Ota, Heiwa Kanamori, Takehiko Mori, Hirohisa Nakamae, Tetsuya Eto, Souichi Shiratori, Tetsuo Maeda, Koji Iwato, Tatsuo Ichinohe, Yoshinobu Kanda, Junji Tanaka, Yoshiko Atsuta, Shingo Yano
It remains unclear how specific innovations in allogeneic hematopoietic cell transplantation (HCT) attained over the past decades have contributed to improvement in transplantation outcomes. To address this question, we conducted a registry-based study of adults with acute myeloid leukemia in first or second complete remission who underwent allogeneic HCT between 1994 and 2013 from a sibling (N = 1600) or unrelated (N = 2113) donor matched at the antigen level for HLA-A, -B, and -DR. Preliminary analysis led us to focus on comparisons between the 1994-2006 and 2007-2013 periods...
August 14, 2018: Bone Marrow Transplantation
Shinichiro Fujimoto, Tomonori Kawasaki, Kanako K Kumamaru, Yuko Kawaguchi, Tomotaka Dohi, Taichi Okonogi, Keiken Ri, Sou Yamada, Kazuhisa Takamura, Etsuro Kato, Yoshiteru Kato, Makoto Hiki, Shinya Okazaki, Shigeki Aoki, Dimitris Mitsouras, Frank J Rybicki, Hiroyuki Daida
Aims: We evaluated diagnostic accuracy of CT-fractional flow reserve (CT-FFR) computed on-site with a new vendor workstation, against invasive FFR as the reference standard. Methods and results: Retrospective analyses compared CT-FFR of 104 vessels with 30-90% diameter stenosis in 75 patients imaged using single-rotation 320 detector-row coronary CT angiography (CCTA) with invasive FFR performed within 90 days. Prospective ECG-gated CCTA included exposure of 70-99% of the R-R interval...
August 10, 2018: European Heart Journal Cardiovascular Imaging
Yoshinori Aoki, Daisuke Nishizawa, Kaori Yoshida, Junko Hasegawa, Shinya Kasai, Kaori Takahashi, Yoshihiko Koukita, Tatsuya Ichinohe, Masakazu Hayashida, Ken-Ichi Fukuda, Kazutaka Ikeda
BACKGROUND: Activating transcription factor 2 (ATF2) is a member of the leucine zipper family of DNA binding proteins and is widely distributed in tissues. Several recent studies have demonstrated that this protein is involved in mechanisms that are related to pain and inflammation. However, unclear is whether polymorphisms of the ATF2 gene, which encodes the human ATF2 protein, influence pain or analgesic sensitivity. This study examined associations between the analgesic effect of fentanyl in the cold pressor-induced pain test and polymorphisms in the ATF2 gene in 355 Japanese subjects...
June 2018: Neuropsychopharmacology reports
Tomoya Yamasaki, Takashi Yoshioka, Masaya Imoto, Hiroshi Aoki, Kei Fujio, Shinya Uehara, Hideo Otsuki
We present a case of a 45-year-old female who experienced rupture of a right calyceal diverticulum caused by ureteroscopy. Fifteen hours after the operation, she had severe right flank pain and a high fever (38.9°C). Computed tomography revealed perinephric extravasation of urine and bleeding inside the diverticulum. We diagnosed rupture of a calyceal diverticulum; therefore, we continued antibiotic administration and pain relief medication. She became afebrile on postoperative day 4 and was discharged from the hospital on postoperative day 7...
2018: Case Reports in Urology
Yi-Wen Chen, Ang Doma Sherpa, Chiye Aoki
OBJECTIVE: This study tested the effects of ketamine on vulnerability of female adolescent mice to activity-based anorexia (ABA). METHOD: Twenty-four female C57Bl/6 J mice underwent ABA induction, which involved exposing wheel-acclimated adolescent mice to two bouts of food restriction (FR)-the first ABA (P41-44, mid-adolescence) and the second ABA (P55-59, late adolescence), with recovery in between. Ketamine (3 or 30 mg/kg) or vehicle was given once, on the second day of FR of the first ABA (P42)...
August 13, 2018: International Journal of Eating Disorders
Tsubasa Kawasaki, Kyohei Mikami, Tsutomu Kamo, Ryoma Aoki, Rumiko Ishiguro, Hiroshi Nakamura, Ryosuke Tozawa, Nao Asada, Yukinobu Hiiragi, Yoichi Yamada, Masahiro Hirano, Kazuko Katsuki
This study aimed to investigate (a) motor planning difficulty by using a two-step test in Parkinson's disease (PD) compared with age-matched healthy subjects and (b) the relationship between motor planning difficulty and clinical factors. The two-step test was performed by 58 patients with PD with Hoehn & Yahr (H&Y) stage I-IV and 110 age-matched healthy older adult controls. In the two-step test, the participants estimated the two-step distance with maximum effort. Subsequently, they performed the actual two-step trial to measure the actual maximum distance...
2018: PloS One
Noriko Otsuki, Reiko Arakawa, Kaori Kaneko, Ryoko Aoki, Masayuki Arakawa, Kayoko Saito
Spinal muscular atrophy (SMA) is a severe genetic neuromuscular disorder caused by insufficiency of functional survival motor neuron (SMN) protein. Several clinical trials have been conducted with the aim of upregulating the expression of the SMN protein in SMA patients. In order to evaluate the efficiency of these SMN-targeted approaches, it has become necessary to verify SMN protein levels in the cells of SMA patients. Accordingly, we have developed a method allowing the evaluation of the functional SMN protein with < 1...
2018: PloS One
Hidehisa Someya, Taiki Itoh, Mebae Kato, Shin Aoki
Disaccharide nucleosides, which consist of disaccharide and nucleobase moieties, have been known as a valuable group of natural products having multifarious bioactivities. Although chemical O-glycosylation is a commonly beneficial strategy to synthesize disaccharide nucleosides, the preparation of substrates such as glycosyl donors and acceptors requires tedious protecting group manipulations and a purification at each synthetic step. Meanwhile, several research groups have reported that boronic and borinic esters serve as a protecting or activating group of carbohydrate derivatives to achieve the regio- and/or stereoselective acylation, alkylation, silylation, and glycosylation...
July 26, 2018: Journal of Visualized Experiments: JoVE
Tatsuhiko Urakami, Midori Miyata, Kei Yoshida, Yusuke Mine, Remi Kuwabara, Masako Aoki, Junichi Suzuki
OBJECTIVE: To analyze changes in the annual incidence of school students with type 2 diabetes detected by urine glucose screening at schools in the Tokyo Metropolitan Area during 1975-2015. METHODS: Trend in temporal changes in the annual incidence rate were analyzed using a joinpoint regression model and the joinpoints. Annual percent change (APC) was calculated for each segmented line regression. Average annual percent change (AAPC) was also calculated for the whole period analyzed...
August 12, 2018: Pediatric Diabetes
Masashi Ryo, Takafumi Yamashino, Hisanori Yamakawa, Yuichi Fujita, Setsuyuki Aoki
Two-component systems, versatile signaling mechanisms based on phosphate transfer between component proteins, must have played important roles in adaptation and diversification processes in land plant evolution. We previously demonstrated that two Per-Arnt-Sim (PAS)-histidine kinases, PHK1 and PHK2, repress gametophore formation in the moss Physcomitrella patens under aerobic conditions, and that, in eukaryotes, the presence of their homologs is restricted to early-diverging streptophyte linages. We assessed here whether or not PHKs play a role in oxygen signaling...
August 9, 2018: Biochemical and Biophysical Research Communications
Hiroshi Ueno, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Yosuke Matsumoto, Shozo Aoki, Motoi Okamoto, Takeshi Ishihara
In the central nervous system (CNS), extracellular matrix (ECM) molecules comprise more than 20% of the volume and are involved in neuronal plasticity, synaptic transmission, and differentiation. Perineuronal nets (PNNs) are ECM molecules that highly accumulate around the soma of neurons. The components of the ECM in the CNS include proteins, proteoglycans, and glycosaminoglycans. Although hyaluronic acid (HA) is considered a constituent element of PNNs, the distribution of HA in the cortex has not been clarified...
August 9, 2018: Brain Research
Nader Rajaei, Naoya Aoki, Haruka K Takahashi, Tetsu Miyaoka, Takanori Kochiyama, Masahiro Ohka, Norihiro Sadato, Ryo Kitada
Humans are adept at perceiving textures through touch. Previous neuroimaging studies have identified a distributed network of brain regions involved in the tactile perception of texture. However, it remains unclear how nodes in this network contribute to the tactile awareness of texture. To examine the hypothesis that such awareness involves the interaction of the primary somatosensory cortex with higher order cortices, we conducted a functional magnetic resonance imaging (fMRI) study utilizing the velvet hand illusion, in which an illusory velvet-like surface is perceived between the hands...
August 10, 2018: Human Brain Mapping
Yosuke Takamura, Wataru Aoki, Atsushi Satomura, Seiji Shibasaki, Mitsuyoshi Ueda
Rheumatoid arthritis (RA) is an autoimmune disease that causes the chronic inflammation of the joints. Intercellular communication containing synovial fibroblasts seems to play a major role in RA pathogenesis. In this study, to better understand intercellular communication related to RA pathogenesis, we identified exosomal microRNAs (miRNAs) derived from synovial fibroblasts. Exosomes were collected from an RA synovial fibroblast (RASF) cell line, namely, MH7A, with or without stimulation by tumor necrosis factor alpha (TNF-α)...
2018: PloS One
Michael R Karns, Daniel L Jones, Dane C Todd, Travis G Maak, Stephen K Aoki, Robert T Burks, Minkyoung Yoo, Richard E Nelson, Patrick E Greis
Background: Few studies have investigated the influence of patient-specific variables or procedure-specific factors on the overall cost of anterior cruciate ligament reconstruction (ACLR) in an ambulatory surgery setting. Purpose: To determine patient- and procedure-specific factors influencing the overall direct cost of outpatient arthroscopic ACLR utilizing a unique value-driven outcomes (VDO) tool. Study Design: Cohort study (economic and decision analysis); Level of evidence, 3...
August 2018: Orthopaedic Journal of Sports Medicine
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