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Cerebral hypoperfusion injury

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https://www.readbyqxmd.com/read/30545240/the-efficacy-of-near-infrared-spectroscopy-monitoring-in-carotid-endarterectomy-a-prospective-single-center-observational-study
#1
Yu Wang, Li Li, Tianlong Wang, Lei Zhao, Hua Feng, Qian Wang, Long Fan, Xuexin Feng, Wei Xiao, Kunpeng Feng
There has been no gold standard for intraoperative monitoring in carotid endarterectomy (CEA) till now. The purpose of the current study was to investigate the value of near-infrared spectroscopy (NIRS) monitoring in CEA and explore the thresholds for intraoperative cerebral hypoperfusion. Eighty-four consecutive patients who underwent CEA surgery in Xuan Wu Hospital of Capital Medical University from August 2015 to June 2016 were enrolled in this study. All patients were intraoperatively monitored by transcranial Doppler ultrasonography (TCD) and NIRS...
December 14, 2018: Cell Transplantation
https://www.readbyqxmd.com/read/30543556/pulse-pressure-and-perioperative-stroke
#2
Abbas Al-Qamari, Ibukunoluwa Adeleke, Adam Kretzer, Charles W Hogue
PURPOSE OF REVIEW: Central pulse pressure (PP), a marker of vascular stiffness, is a novel indicator of risk for perioperative morbidity including ischemic stroke. Appreciation for the mechanism by which vascular stiffness leads to organ dysfunction along with understanding its clinical detection may lead to improved patient management. RECENT FINDINGS: Vascular stiffness is associated with increased mortality and neurologic, cardiac, and renal injury in nonsurgical and surgical patients...
December 12, 2018: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/30539815/-xiao-xu-ming-decoction-extract-regulates-differentially-expressed-proteins-in-the-hippocampus-after-chronic-cerebral-hypoperfusion
#3
Yue-Hua Wang, Ying-Lin Yang, Xiao Cheng, Jun Zhang, Wan Li, Guan-Hua Du
Xiao-Xu-Ming decoction has been widely used to treat stroke and sequelae of stroke. We have previously shown that the active fractions of Xiao-Xu-Ming decoction attenuate cerebral ischemic injury. However, the global protein profile and signaling conduction pathways regulated by Xiao-Xu-Ming decoction are still unclear. This study established a two-vessel occlusion rat model by bilateral common carotid artery occlusion. Rats were intragastrically administered 50 or 150 mg/kg Xiao-Xu-Ming decoction for 4 consecutive weeks...
March 2019: Neural Regeneration Research
https://www.readbyqxmd.com/read/30497184/microrna-195-protection-against-focal-cerebral-ischemia-by-targeting-cx3cr1
#4
(no author information available yet)
OBJECTIVEIt has been reported that microRNA-195 (miR-195) protects against chronic brain injury induced by chronic brain hypoperfusion. However, neither the expression profile of miR-195 nor its potential role during acute ischemic stroke has been investigated. In this study, the authors' aim was to verify the mechanism of miR-195 in acute ischemic stroke.METHODSThe plasma levels of miR-195 expression were assessed using real-time PCR in 96 patients with acute ischemic stroke, and the correlation with the National Institutes of Health Stroke Scale score was evaluated...
November 1, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/30443885/the-acute-phase-of-experimental-subarachnoid-hemorrhage-intracranial-pressure-dynamics-and-their-effect-on-cerebral-blood-flow-and-autoregulation
#5
Catharina Conzen, Katrin Becker, Walid Albanna, Miriam Weiss, Annika Bach, Nyanda Lushina, André Steimers, Sarah Pinkernell, Hans Clusmann, Ute Lindauer, Gerrit A Schubert
Clinical presentation and neurological outcome in subarachnoid hemorrhage (SAH) is highly variable. Aneurysmal SAH (aSAH) is hallmarked by sudden increase of intracranial pressure (ICP) and acute hypoperfusion contributing to early brain injury (EBI) and worse outcome, while milder or non-aneurysmal SAH with comparable amount of blood are associated with better neurological outcome, possibly due to less dramatic changes in ICP. Acute pressure dynamics may therefore be an important pathophysiological aspect determining neurological complications and outcome...
November 15, 2018: Translational Stroke Research
https://www.readbyqxmd.com/read/30416654/olfactory-ensheathing-cells-transplantation-attenuates-chronic-cerebral-hypoperfusion-induced-cognitive-dysfunction-and-brain-damages-by-activating-nrf2-ho-1-signaling-pathway
#6
Ailing Yu, Leilei Mao, Fangfang Zhao, Baoliang Sun
Chronic cerebral hypoperfusion (CCH) has become a crucial factor contributing to neurological disorders and cognitive deficits. Olfactory ensheathing cells (OECs) transplantation has been widely used to repair central nerve systems (CNS) injury, however, whether this intervention has therapeutic effects on CCH-induced cognitive dysfunction and brain damages is still unknown. In this study, we sought to determine the potential therapeutic effects of OECs transplantation on CCH. Two days after the establishment of 2VO rat model, OECs or its medium transplantation were performed via intrastriatal injection...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/30405422/icariside-ii-ameliorates-cognitive-impairments-induced-by-chronic-cerebral-hypoperfusion-by-inhibiting-the-amyloidogenic-pathway-involvement-of-bdnf-trkb-creb-signaling-and-up-regulation-of-ppar%C3%AE-and-ppar%C3%AE-in-rats
#7
Caixia Yin, Yuanyuan Deng, Yuangui Liu, Jianmei Gao, Lingli Yan, Qihai Gong
Chronic cerebral hypoperfusion (CCH) is regarded as a high-risk factor for cognitive decline of vascular dementia (VD) as it is conducive to induce beta-amyloid (Aβ) aggregation. Icariside II (ICS II), a plant-derived flavonoid compound, has showed neuroprotective effect on animal models of Alzheimer's disease (AD) by decreasing Aβ levels. Here, we assessed the effect of ICS II on CCH-induced cognitive deficits and Aβ levels in rats, and the possible underlying mechanisms were also explored. It was disclosed that CCH induced by bilateral common carotid artery occlusion (BCCAO) caused cognitive deficits, neuronal injury and increase of Aβ1-40 and Aβ1-42 levels in the rat hippocampus, while oral administration of ICS II for 28 days abolished the above deficits in the hippocampus of BCCAO rats...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/30382185/cz-7-a-new-derivative-of-claulansine-f-ameliorates-2vo-induced-vascular-dementia-in-rats-through-a-nrf2-mediated-antioxidant-responses
#8
Dan-Dan Liu, Xia Yuan, Shi-Feng Chu, Chen Chen, Qian Ren, Piao Luo, Mei-Yu Lin, Sha-Sha Wang, Tian-Bi Zhu, Qi-di Ai, Ying-da Zang, Dong-Ming Zhang, Xin He, Zhi-Hua Huang, Hong-Shuo Sun, Zhong-Ping Feng, Nai-Hong Chen
Vascular dementia (VD) results from accumulated damage in the vascular system, which is characterized by progressive impairments in memory and cognition and is second only to Alzheimer's disease (AD) in prevalence among all types of dementia. In contrast to AD, there is no FDA-approved treatment for VD owing to its multiple etiologies. In this study, we investigated whether CZ-7, a new derivative of Claulansine F (Clau F) with verified neuroprotective activity in vitro, could ameliorate the cognitive impairment of rats with permanent occlusion of bilateral common carotid arteries (2VO) and its potential mechanisms of action...
October 31, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/30380944/cerebral-blood-flow-in-children-and-adolescents-several-years-after-concussion
#9
Brian L Brooks, Trevor A Low, Vickie Plourde, Shane Virani, Zeanna Jadavji, Frank P MacMaster, Karen M Barlow, R Marc Lebel, Keith Owen Yeates
OBJECTIVES: The long-term effects of concussion in youth remain poorly understood. The objective of this study was to determine the association between history of concussion and cerebral blood flow (CBF) in youth. METHODS: A total of 53 children and adolescents with a history of concussion (n = 37) or orthopaedic injury (OI; n = 16) were considered. Measures included pseudo-continuous arterial spin labelling magnetic resonance imaging to quantify CBF, post-concussion symptoms, psychological symptoms, and cognitive testing...
October 31, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/30343686/soluble-epoxide-hydrolase-inhibition-alleviated-cognitive-impairments-via-nrg1-erbb4-signaling-after-chronic-cerebral-hypoperfusion-induced-by-bilateral-carotid-artery-stenosis-in-mice
#10
Jiahuan Hao, Yuxue Chen, Ensheng Yao, Xinghua Liu
Cerebral ischemic stroke is associated with a high rate of incidence, prevalence and mortality globally. Carotid artery stenosis, which is mainly caused by atherosclerosis plaque, results in chronic cerebral hypoperfusion and predominantly increases the risk of ischemic stroke. In the present study, we used bilateral common carotid artery stenosis (BCAS) model by placing microcoils of 0.18 mm diameter encompassing both common carotid arteries respectively, to mimic the pathogenesis of carotid artery atherosclerosis and intensively explore the pathology...
November 15, 2018: Brain Research
https://www.readbyqxmd.com/read/30283542/burr-holes-revascularization-in-three-pediatric-cases-of-moyamoya-syndrome-easy-choice-or-insidious-trap-case-series-and-review
#11
Mattia Pacetti, Domenico Tortora, Pietro Fiaschi, Alessandro Consales, Gianluca Piatelli, Marcello Ravegnani, Armando Cama, Marco Pavanello
Introduction: Moyamoya disease is a steno-occlusive cerebrovascular disease of unknown etiology involving the terminal portion of the internal carotid artery and the proximal portions of the anterior and middle cerebral arteries with associated collateral vascular network. When the vascular pattern is associated with a particular condition (e.g., Type 1 neurofibromatosis, Down syndrome), it is defined as moyamoya syndrome (MMS) (or quasi-moyamoya). Among different indirect bypass techniques used to prevent ischemic injury by increasing collateral blood flow to hypoperfused areas of the cortex, multiple burr holes technique is an easy and diffuse indirect revascularization approach in the treatment of moyamoya...
July 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/30270845/late-failure-of-cerebral-autoregulation-in-hypoxic-ischemic-encephalopathy-is-associated-with-brain-injury-a-pilot-study
#12
Zachary A Vesoulis, Steve M Liao, Amit M Mathur
Post-resuscitation reperfusion following hypoxic-ischemia (HIE) is associated with secondary brain injury in neonates. 
 
 Objective: To quantify the association between perfusion exceeding autoregulatory limits and brain injury.
 
 Methods: Continuous mean arterial blood pressure (MABP) and cerebral near-infrared spectroscopy (NIRS) data were prospectively collected from infants with HIE. Cerebral oximetry index (COx) was calculated as a moving correlation coefficient between MABP and NIRS...
October 1, 2018: Physiological Measurement
https://www.readbyqxmd.com/read/30269810/is-technology-for-orthostatic-hypotension-ready-for-primetime
#13
REVIEW
Zoe K Sarafis, Aaron K Monga, Aaron A Phillips, Andrei V Krassioukov
Spinal cord injury (SCI) often results in the devastating loss of motor, sensory, and autonomic function. After SCI, the interruption of descending sympathoexcitatory pathways disrupts supraspinal control of blood pressure (BP). A common clinical consequence of cardiovascular dysfunction after SCI is orthostatic hypotension (OH), a debilitating condition characterized by rapid profound decreases in BP when assuming an upright posture. OH can result in a diverse array of insidious and pernicious health consequences...
September 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/30228838/advanced-neuroimaging-in-balo-s-concentric-sclerosis-mri-mrs-dti-and-asl-perfusion-imaging-over-1-year
#14
Crystal Jing Jing Yeo, George J Hutton, Steve H Fung
Balo concentric sclerosis (BCS) is a rare, atypical demyelinating disease, which may rapidly progress to become severe and fatal. Advanced neuroimaging has proven helpful for early diagnosis, classification, prognostication, and monitoring of progression in multiple sclerosis, but has not been fully explored in BCS. We present the case of a 27-year-old woman with BCS in whom advanced neuroimaging was used to correlate the evolution of disease with clinical findings over the course of 1 year. Magnetic resonance imaging, magnetic resonance spectroscopy (MRS), diffusion tensor imaging (DTI), and arterial spin labeling cerebral perfusion were obtained at presentation (Day 0), and at Day 67 and Day 252...
October 2018: Radiology Case Reports
https://www.readbyqxmd.com/read/30196311/neonatal-cerebrovascular-autoregulation
#15
REVIEW
Christopher J Rhee, Cristine Sortica da Costa, Topun Austin, Ken M Brady, Marek Czosnyka, Jennifer K Lee
Cerebrovascular pressure autoregulation is the physiologic mechanism that holds cerebral blood flow (CBF) relatively constant across changes in cerebral perfusion pressure (CPP). Cerebral vasoreactivity refers to the vasoconstriction and vasodilation that occur during fluctuations in arterial blood pressure (ABP) to maintain autoregulation. These are vital protective mechanisms of the brain. Impairments in pressure autoregulation increase the risk of brain injury and persistent neurologic disability. Autoregulation may be impaired during various neonatal disease states including prematurity, hypoxic-ischemic encephalopathy (HIE), intraventricular hemorrhage, congenital cardiac disease, and infants requiring extracorporeal membrane oxygenation (ECMO)...
September 8, 2018: Pediatric Research
https://www.readbyqxmd.com/read/30192196/a-refined-model-of-chronic-cerebral-hypoperfusion-resulting-in-cognitive-impairment-and-a-low-mortality-rate-in-rats
#16
Ahmed Mansour, Kuniyasu Niizuma, Sherif Rashad, Akira Sumiyoshi, Rie Ryoke, Hidenori Endo, Toshiki Endo, Kenichi Sato, Ryuta Kawashima, Teiji Tominaga
OBJECTIVE The cognitive deficits of vascular dementia and the vasoocclusive state of moyamoya disease have often been mimicked with bilateral stenosis/occlusion of the common carotid artery (CCA) or internal carotid artery. However, the cerebral blood flow (CBF) declines abruptly in these models after ligation of the CCA, which differs from "chronic" cerebral hypoperfusion. While some modified but time-consuming techniques have used staged occlusion of both CCAs, others used microcoils for CCA stenosis, producing an adverse effect on the arterial endothelium...
September 7, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/30178324/cerebral-hemodynamics-after-transcranial-direct-current-stimulation-tdcs-in-patients-with-consequences-of-traumatic-brain-injury
#17
Alexey O Trofimov, George Kalentiev, Michael Karelsky, Cristina Ksenofontova, Alevtina Ruzavina, Michail Yuriev, Denis E Bragin
In recent years, hopes for better treatment of traumatic brain injury (TBI) have focused on non-pharmacologic transcranial electrical brain stimulation; however, studies of perfusion changes after stimulation are few and contradictory. Therefore, the aim of this study was to assess cerebral perfusion after high-definition transcranial direct current stimulation (HD-tDCS) in patients with posttraumatic encephalopathy (PTE). METHODS: Twenty patients with PTE (16 men and 4 women, aged 35...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/30149778/perinatal-hypoxic-ischemic-brain-injury-in-large-animal-models-relevance-to-human-neonatal-encephalopathy
#18
Raymond C Koehler, Zeng-Jin Yang, Jennifer K Lee, Lee J Martin
Perinatal hypoxia-ischemia resulting in death or lifelong disabilities remains a major clinical disorder. Neonatal models of hypoxia-ischemia in rodents have enhanced our understanding of cellular mechanisms of neural injury in developing brain, but have limitations in simulating the range, accuracy, and physiology of clinical hypoxia-ischemia and the relevant systems neuropathology that contribute to the human brain injury pattern. Large animal models of perinatal hypoxia-ischemia, such as partial or complete asphyxia at the time of delivery of fetal monkeys, umbilical cord occlusion and cerebral hypoperfusion at different stages of gestation in fetal sheep, and severe hypoxia and hypoperfusion in newborn piglets, have largely overcome these limitations...
December 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/30092283/topological-remodeling-of-cortical-perineuronal-nets-in-focal-cerebral-ischemia-and-mild-hypoperfusion
#19
Egor Dzyubenko, Daniel Manrique-Castano, Christoph Kleinschnitz, Andreas Faissner, Dirk M Hermann
Despite the crucial role of perineuronal nets (PNNs) in neural plasticity and neurological disorders, their ultrastructural organization remains largely unresolved. We have developed a novel approach combining superresolution structured illumination microscopy (SR-SIM) and mathematical reconstruction that allows for quantitative analysis of PNN topology. Since perineuronal matrix is capable to restrict neural plasticity but at the same time is necessary to maintain synapses, we hypothesized that a beneficial post stroke recovery requires a reversible loosening of PNNs...
August 6, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/30084882/brain-perfusion-regional-volumes-and-cognitive-function-in-hiv-positive-patients-treated-with-protease-inhibitor-monotherapy
#20
Lewis J Haddow, Claudia Godi, Magdalena Sokolska, M Jorge Cardoso, Ruth Oliver, Alan Winston, Wolfgang Stöhr, Amanda Clarke, Fabian Chen, Ian G Williams, Margaret Johnson, Nick Paton, Alejandro Arenas-Pinto, Xavier Golay, Hans Rolf Jäger
Background: Protease inhibitor monotherapy (PIM) for HIV may exert suboptimal viral control in the central nervous system. We determined whether cerebral blood flow (CBF) and regional brain volumes were associated with PIM, and whether specific cognitive domains were associated with imaging biomarkers. Methods: Cognitive assessment and brain MRI were performed after the final visit of a randomized HIV treatment strategy trial. Participants were virologically suppressed on triple therapy at trial entry and followed for 3-5 years...
July 31, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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