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https://www.readbyqxmd.com/read/30317446/a-simple-highly-sensitive-colorimetric-immunosensor-for-the-detection-of-alternariol-monomethyl-ether-in-fruit-by-non-aggregated-gold-nanoparticles
#1
Yan Man, Junan Ren, Bingru Li, Xinxin Jin, Ligang Pan
Alternariol monomethyl ether (AME) is one of the major Alternaria mycotoxins present in a wide range of fruits, vegetables, grains, and their products, and possesses the properties of mutagenicity and carcinogenicity. In this study, a simple, rapid, and highly sensitive colorimetric immunosensor based on magnetic nanoparticles (MNPs) was firstly developed for the detection of AME in fruit by nonaggregated gold nanoparticles (GNPs). AME-BSA-Fe3 O4 MNP conjugates and free AME molecules in samples competitively bind with monoclonal antibody (mAb)-GNP conjugates...
October 13, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/30317041/highly-effective-oxidation-of-roxarsone-by-ferrate-and-simultaneous-arsenic-removal-with-in-situ-formed-ferric-nanoparticles
#2
Tao Yang, Yulei Liu, Lu Wang, Jin Jiang, Zhuangsong Huang, Su-Yan Pang, Haijun Cheng, Dawen Gao, Jun Ma
Roxarsone (ROX) is used in breeding industry to prevent infection by parasites, stimulate livestock growth and improve pigmentation of livestock meat. After being released into environment, ROX could be bio-degraded with the formation of carcinogenic inorganic arsenic (As) species. Here, ferrate oxidation of ROX was reported, in which we studied total-As removal, determined reaction kinetics, identified oxidation products, and proposed a reaction mechanism. It was found that the apparent second-order rate constant (kapp ) of ferrate with ROX was 305 M-1 s-1  at pH 7...
October 7, 2018: Water Research
https://www.readbyqxmd.com/read/30316845/metabolism-of-4-methylimidazole-in-fischer-344-rats-and-b6c3f1-mice
#3
Timothy R Fennell, Scott L Watson, Suraj Dhungana, Rodney W Snyder
4-Methylimidazole (4-MeI) is a widely used chemical, also identified as a by-product of heating foods. In cancer bioassays, 4-MeI induced lung tumors in mice, but not in rats. To establish if metabolic differences could explain species difference in carcinogenicity, this study investigated metabolism of 4-MeI in rat and mouse lung and liver microsomes and S-9 fractions, and in vivo in rats and mice. No metabolites were detected in rat or mouse lung and liver microsomes, or lung S-9 fractions. Male and female F-344 rats and B6C3F1 mice were administered 50 and 150 mg/kg [14 C] 4-MeI by gavage...
October 11, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/30316843/2-6-dimethoxy-1-4-benzoquinone-isolation-and-identification-of-anti-carcinogenic-anti-mutagenic-and-anti-inflammatory-component-from-the-juice-of-vitis-coignetiae
#4
Tomonori Kamiya, Yusuke Tanimoto, Nana Fujii, Tomoe Negishi, Toshinori Suzuki, Tsutomu Hatano, Sakae Arimoto-Kobayashi
Previously we demonstrated the anti-tumorigenic, anti-mutagenic and anti-inflammatory effects of the juice of Vitis coignetiae (yamabudo), and identified caftaric acid as an anti-mutagenic component from the juice. In the present study, we investigated the isolation of anti-inflammatory components in yamabudo juice supposing that the anti-inflammatory components in yamabudo are also responsible for the anti-tumorigenic activity. The suppressing effect on nitric oxide production in mouse leukemic monocyte with LPS was used as a separation marker...
October 11, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/30316012/neoantigenic-potential-of-complex-chromosomal-rearrangements-in-mesothelioma
#5
Aaron S Mansfield, Tobias Peikert, James B Smadbeck, Julia B M Udell, Enrique Garcia-Rivera, Laura Elsbernd, Courtney L Erskine, Virginia P Van Keulen, Farhad Kosari, Stephen J Murphy, Hongzheng Ren, Vishnu V Serla, Janet L Schaefer Klein, Giannoula Karagouga, Faye R Harris, Carlos Sosa, Sarah H Johnson, Wendy Nevala, Svetomir N Markovic, Aaron O Bungum, Eric S Edell, Haidong Dong, John C Cheville, Marie Christine Aubry, Jin Jen, George Vasmatzis
INTRODUCTION: Malignant pleural mesothelioma is a disease primarily associated with exposure to the carcinogen asbestos. Whereas other carcinogen-related tumors are associated with a high tumor mutation burden, mesothelioma is not. We sought to resolve this discrepancy. MATERIAL AND METHODS: We used mate-pair (n=22), RNA (n=28) and T cell receptor sequencing along with in silico predictions and immunologic assays to understand how structural variants of chromosomes affect the transcriptome...
October 10, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/30315953/in-silico-prediction-of-heterocyclic-aromatic-amines-metabolism-susceptible-to-form-dna-adducts-in-humans
#6
Victorien Delannée, Sophie Langouët, Anne Siegel, Nathalie Théret
Heterocyclic aromatic amines (HAAs) are environmental and food contaminants that are classified as probable or possible carcinogens by the International Agency for Research on Cancer. Thirty different HAAs have been identified. However the metabolism of only three of them have been fully characterized in human hepatocytes: AαC (2-amino-9H-pyrido[2,3-b]indole), MeIQx (2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline) and PhIP (2-amino-1-methyl-6-phenyl-imidazo[4,5-b]pyridine). In this study, we use an integrative approach to accurately predict the biotransformation of 30 HAAs into DNA reactive and non DNA reactive compounds...
October 10, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/30315950/chromium-vi-promotes-cell-migration-through-targeting-epithelial-mesenchymal-transition-in-prostate-cancer
#7
Changwen Zhang, Keke Cai, Qijin Feng, Yong Xu, Zhihong Zhang
Chromium (Cr) is widely used in industry, making its toxicity a matter of concern. Although hexavalent Cr [Cr(VI)] can promote cancer cell proliferation in several cancers, there is little evidence implicating Cr(VI) in cancer cell migration, especially in prostate cancer. We show that the Cr concentration is higher in the serum of prostate cancer patients, and is closely associated with unfavorable outcomes for the patients. Additionally, low dose trivalent Cr [Cr(III)] exposure has no obvious carcinogenic effects in prostate cancer...
October 10, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/30315534/heavy-metal-quantification-of-classroom-dust-in-school-environment-and-its-impacts-on-children-health-from-rawang-malaysia
#8
Sock Yin Tan, Sarva Mangala Praveena, Emilia Zainal Abidin, Manraj Singh Cheema
This study aimed to determine bioavailable heavy metal concentrations (As, Cd, Co, Cu, Cr, Ni, Pb, Zn) and their potential sources in classroom dust collected from children's hand palms in Rawang (Malaysia). This study also aimed to determine the association between bioavailable heavy metal concentration in classroom dust and children's respiratory symptoms. Health risk assessment (HRA) was applied to evaluate health risks (non-carcinogenic and carcinogenic) due to heavy metals in classroom dust. The mean of bioavailable heavy metal concentrations in classroom dust found on children's hand palms was shown in the following order: Zn (1...
October 12, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/30314695/knockout-of-raptor-destabilizes-ornithine-decarboxylase-mrna-and-decreases-binding-of-hur-to-the-odc-transcript-in-cells-exposed-to-ultraviolet-b-irradiation
#9
Shannon L Nowotarski, Robert P Feehan, Christopher Presloid, Lisa M Shantz
Non-melanoma skin cancer (NMSC) is the most commonly diagnosed cancer in the United States. Ultraviolet-B (UVB) irradiation is the primary carcinogen responsible for stimulating NMSC development. Ornithine Decarboxylase (ODC), the first rate-limiting enzyme in the synthesis of polyamines, is upregulated in response to a variety of proliferation stimuli, including UVB exposure. Our previous studies have demonstrated regulation of ODC synthesis by the mammalian target of rapamycin complex 1 (mTORC1) in cells transformed by oncogenic Ras...
October 9, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/30312965/a-bayesian-generalized-log-normal-model-to-dynamically-evaluate-the-distribution-of-pesticide-residues-in-soil-associated-with-population-health-risks
#10
Zijian Li
Exploring better models for evaluating the distribution of pesticide residues in soil and sediment is necessary to assess and avoid population health risk. Frequentist philosophy and probability are widely used in many studies to apply a log-normal distribution associated with the maximum likelihood estimation, which assumes fixed parameters and relies on a large sample size for long-run frequency. However, frequentist probability might not be suitable for analyzing pesticide residue distribution, whose parameters are affected by many complex factors and should be treated as unfixed...
October 9, 2018: Environment International
https://www.readbyqxmd.com/read/30312948/establishing-a-health-risk-assessment-for-metal-speciation-in-soil-a-case-study-in-an-industrial-area-in-china
#11
Yimei Zhang, Jie Chen, Liqun Wang, Yalong Zhao, Ping Ou, WeiLin Shi
An improved method was proposed which integrates the distribution of metal speciation simulated by chemical equilibrium model, different exposure models and average daily intake dose modified by analytic hierarchy process for human health risk assessment of metal species (MS). With the rapid development of economic and urbanization, the metals pollution had become more serious in industrial areas. Adverse effects of soil contaminants on human health in typical industrial area should be assessed to evaluate the risks of soils in these areas...
October 9, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/30312928/environmentally-friendly-polychlorinated-naphthalenes-pcns-derivatives-designed-using-3d-qsar-and-screened-using-molecular-docking-density-functional-theory-and-health-based-risk-assessment
#12
Wenwen Gu, Yuanyuan Zhao, Qing Li, Yu Li
A complete design and screening system for environmental-friendly polychlorinated naphthalene (PCN) derivatives was established through three-dimensional quantitative structure-activity relationship (3D-QSAR), molecular docking, density functional theory (DFT) methods and health-based risk assessment based on dynamic multimedia fugacity model. Two types of 3D-QSAR models were established for PCNs using the experimental biological toxicity (logEC50 ) of 14 PCNs to carry out a modification to lower the logEC50 of CN-70...
September 27, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/30312850/safrole-induced-cytotoxicity-dna-damage-and-apoptosis-in-macrophages-via-reactive-oxygen-species-generation-and-akt-phosphorylation
#13
Kuang-Jen Chien, Ming-Ling Yang, Ping-Kun Tsai, Chun-Hung Su, Chia-Hui Chen, Chi-Ting Horng, Chung-Hsin Yeh, Wen-Ying Chen, Meng-Liang Lin, Chun-Jung Chen, Chen-Yu Chian, Yu-Hsiang Kuan
Safrole is a natural compound categorized as a group 2B carcinogen extracted from betel quid chewing, which is a common practice of psychoactive habits integrated into social and cultural ceremonies among serveral million people, especially in Southern or Southeastern Asia. Safrole is one of the major risk compunds for development of oral squamous cell carcinoma and hepatocellular carcinoma via DNA adduction. In innate immunity, macrophages are the predominant cells for non-specific first line defense against pathogens in oral tissue...
September 29, 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/30312759/iron-addiction-with-ferroptosis-resistance-in-asbestos-induced-mesothelial-carcinogenesis-toward-the-era-of-mesothelioma-prevention
#14
Shinya Toyokuni
Cancer is the primary cause of human mortality in most countries. This tendency has increased as various medical therapeutics have advanced, which suggests that we cannot escape carcinogenesis, although the final outcome may be modified by exposomes and statistics. Cancer is classified by its cellular differentiation. Mesothelial cells are distinct in that they line somatic cavities, facilitating the smooth movement of organs, but are not exposed to the external environment. Malignant mesothelioma, or simply mesothelioma, develops either in the pleural, peritoneal or pericardial cavities, or in the tunica vaginalis testes...
October 9, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/30312431/smoking-and-risk-of-colorectal-cancer-sub-classified-by-tumor-infiltrating-t-cells
#15
Tsuyoshi Hamada, Jonathan A Nowak, Yohei Masugi, David A Drew, Mingyang Song, Yin Cao, Keisuke Kosumi, Kosuke Mima, Tyler S Twombly, Li Liu, Yan Shi, Annacarolina da Silva, Mancang Gu, Wanwan Li, Katsuhiko Nosho, NaNa Keum, Marios Giannakis, Jeffrey A Meyerhardt, Kana Wu, Molin Wang, Andrew T Chan, Edward L Giovannucci, Charles S Fuchs, Reiko Nishihara, Xuehong Zhang, Shuji Ogino
Background: Evidence indicates not only carcinogenic effect of cigarette smoking but also its immunosuppressive effect. We hypothesized that the association of smoking with colorectal cancer risk might be stronger for tumors with lower anti-tumor adaptive immune response. Methods: During follow-up of 134 981 participants (3 490 851 person-years) in the Nurses' Health Study and Health Professionals Follow-up Study, we documented 729 rectal and colon cancer cases with available data on T-cell densities in tumor microenvironment...
October 11, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/30312218/hpv-6-associated-hsil-squamous-carcinoma-in-the-anogenital-tract
#16
Martina Z Liu, Yin P Hung, Eric C Huang, Brooke E Howitt, Marisa R Nucci, Christopher P Crum
Human papillomavirus (HPV) type 6 is historically classified as low-risk HPV type and associates with low-grade squamous intraepithelial lesions of the anogenital tract. Rare squamous carcinomas have been reported in association with these HPV types but the mechanism(s) behind this carcinogenic sequence have been unclear. We report 4 cases of low risk anogenital HPV infections-3 cervical (immature low-grade squamous intraepithelial lesion with metaplastic phenotype) and one anal (exophytic condyloma) lesion-that manifested with high-grade squamous intraepithelial lesion/squamous cell carcinoma...
October 11, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/30312029/tannic-acid-solution-a-better-fixative-solution-than-formalin-for-elastin-and-collagen-toxic-and-morphological-assessment
#17
Rafael Cisne, Alessandra M T Souza, Marco A Pereira-Sampaio, Marcio A Babinski, Silvana L Gorniak, Paula C Papa
Formaldehyde is commonly used worldwide, even though it is classified as carcinogenic to humans by the International Agency for Research on Cancer. This has motivated intensive investigations of formaldehyde substitutes, and recently, some alternative solutions were found, which can potentially replace it. Previous research showed that tannic acid (TA) in glutaraldehyde solution has the ability to stabilize elastin and collagen. This provided a basis for the development of a new alcoholic fixative solution, particularly aimed at extracellular matrix components, with TA as a main component...
September 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/30311985/response-of-head-and-neck-epithelial-cells-to-a-dna-damage-differentiation-checkpoint-involving-polyploidization
#18
Natalia Sanz-Gómez, Ana Freije, Laura Ceballos, Sergio Obeso, J Ramón Sanz, Fe García-Reija, Carmelo Morales-Angulo, Alberto Gandarillas
BACKGROUND: Squamous epithelia of the head and neck undergo continuous cell renewal and are continuously exposed to mutagenic hazard, the main cause of cancer. How they maintain homeostasis upon cell cycle deregulation is unclear. METHODS: To elucidate how head and neck epithelia respond to cell cycle stress, we studied human keratinocytes from various locations (oral mucosa, tonsil, pharynx, larynx, and trachea). We made use of genotoxic or mitotic drugs (doxorubicin [DOXO], paclitaxel, and nocodazole), or chemical inhibitors of the mitotic checkpoint kinases, Aurora B and polo-like-1...
October 12, 2018: Head & Neck
https://www.readbyqxmd.com/read/30311772/thermal-processing-food-related-toxicants-a-review
#19
Agnieszka Koszucka, Adriana Nowak
Heterocyclic aromatic amines, acrylamide, 5-hydroxymethylfurfural, furan, polycyclic aromatic hydrocarbons, nitrosamines, acrolein, chloropropanols and chloroesters are generated toxicants formed in some foodstuffs, mainly starchy and protein-rich food during thermal treatment such as frying, roasting and baking. The formation of these chemical compounds is associated with development of aromas, colors and flavors. One of the challenges facing the food industry today is to minimize these toxicants without adversely affecting the positive attributes of thermal processing...
October 12, 2018: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/30311575/regulation-of-epithelial-cell-proliferation-differentiation-and-plasticity-by-grainyhead-like-2-during-oral-carcinogenesis
#20
Mo K Kang, Wei Chen, No-Hee Park
Grainyhead-Like 2 (GRHL2) was originally described as one of the three mammalian isoforms with sequence homology to Grainyhead (GRH) in Drosophila, which determines the cuticle formation in fruit flies. Earlier studies characterized GRHL2 as an epithelial-specific transcription factor that regulates epithelial morphogenesis and differentiation. Using a high-throughput proteomic approach, we discovered GRHL2 as a novel trans-regulator of the hTERT gene, which codes for the catalytic subunit of the human telomerase...
2018: Critical Reviews in Oncogenesis
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