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Nutrigenomics

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https://www.readbyqxmd.com/read/29785087/transcriptomic-impacts-of-rumen-epithelium-induced-by-butyrate-infusion-in-dairy-cattle-in-dry-period
#1
Ransom L Baldwin, Robert W Li, Yankai Jia, Cong-Jun Li
The purpose of this study was to evaluate the effects of butyrate infusion on rumen epithelial transcriptome. Next-generation sequencing (NGS) and bioinformatics are used to accelerate our understanding of regulation in rumen epithelial transcriptome of cattle in the dry period induced by butyrate infusion at the level of the whole transcriptome. Butyrate, as an essential element of nutrients, is a histone deacetylase (HDAC) inhibitor that can alter histone acetylation and methylation, and plays a prominent role in regulating genomic activities influencing rumen nutrition utilization and function...
2018: Gene Regulation and Systems Biology
https://www.readbyqxmd.com/read/29781841/carbohydrates-and-diet-patterns-in-nonalcoholic-fatty-liver-disease-in-children-and-adolescents
#2
Ahlia Sekkarie, Jean A Welsh, Miriam B Vos
PURPOSE OF REVIEW: The primary treatment for nonalcoholic fatty liver disease (NAFLD) in children is lifestyle change, including a healthier diet. However, there are no agreed upon expert recommendations for a specific diet in the prevention or treatment of NAFLD. In this study, we review studies published between 2015 and 2017 contributing to further understanding of the role of diet in the development and progression of NAFLD, particularly those addressing sugars and dietary patterns...
May 16, 2018: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/29762088/an-updated-taxonomy-and-a-graphical-summary-tool-for-optimal-classification-and-comprehension-of-omics-research
#3
Nina Pirih, Tanja Kunej
The volume of publications and the type of research approaches used in omics system sciences are vast and continue to expand rapidly. This increased complexity and heterogeneity of omics data are challenging data extraction, sensemaking, analyses, knowledge translation, and interpretation. An extended and dynamic taxonomy for the classification and summary of omics studies are essential. We present an updated taxonomy for classification of omics research studies based on four criteria: (1) type and number of genomic loci in a research study, (2) number of species and biological samples, (3) the type of omics technology (e...
May 2018: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/29736190/ons-an-ontology-for-a-standardized-description-of-interventions-and-observational-studies-in-nutrition
#4
Francesco Vitali, Rosario Lombardo, Damariz Rivero, Fulvio Mattivi, Pietro Franceschi, Alessandra Bordoni, Alessia Trimigno, Francesco Capozzi, Giovanni Felici, Francesco Taglino, Franco Miglietta, Nathalie De Cock, Carl Lachat, Bernard De Baets, Guy De Tré, Mariona Pinart, Katharina Nimptsch, Tobias Pischon, Jildau Bouwman, Duccio Cavalieri
Background: The multidisciplinary nature of nutrition research is one of its main strengths. At the same time, however, it presents a major obstacle to integrate data analysis, especially for the terminological and semantic interpretations that specific research fields or communities are used to. To date, a proper ontology to structure and formalize the concepts used for the description of nutritional studies is still lacking. Results: We have developed the Ontology for Nutritional Studies (ONS) by harmonizing selected pre-existing de facto ontologies with novel health and nutritional terminology classifications...
2018: Genes & Nutrition
https://www.readbyqxmd.com/read/29678078/challenges-in-design-and-creation-of-genetic-openehr-archetype
#5
Priscila A Maranhão, Gustavo Bacelar-Silva, Duarte Gonçalves-Ferreira, Pedro Vieira-Marques, Ricardo Cruz-Correia
Since the Human Genomic Project discovered the sequencing of human genome, the interest about genome content in clinical practice has increased. Genetic information has become a key point to understand diseases or improve treatments, for example, the nutrigenomic and nutrigenetics. However, the huge amount of data generated raises the need for Electronic Health Record (EHR) improvements as it becomes increasingly necessary that it includes more specific genetic information. Thus, we aim to propose standard genetic archetypes (in openEHR) and describe our main challenges in this context...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29659694/nutritional-genomics-and-direct-to-consumer-genetic-testing-an-overview
#6
Marta Guasch-Ferré, Hassan S Dashti, Jordi Merino
The increasing prevalence in polygenic diseases, such as obesity, cardiovascular disease, and type 2 diabetes, observed over the past few decades is more likely linked to a rapid transition in lifestyle rather than to changes in the sequence of the nuclear genome. In the new era of precision medicine, nutritional genomics holds the promise to be translated into tailored nutritional strategies to prevent and manage polygenic diseases more effectively. Nutritional genomics aims to prevent, treat, and manage polygenic diseases through targeted therapies formulated from individuals' genetic makeup and dietary intake...
March 1, 2018: Advances in Nutrition
https://www.readbyqxmd.com/read/29649123/phytochemical-properties-and-nutrigenomic-implications-of-yacon-as-a-potential-source-of-prebiotic-current-evidence-and-future-directions
#7
REVIEW
Yang Cao, Zheng Feei Ma, Hongxia Zhang, Yifan Jin, Yihe Zhang, Frank Hayford
The human gut is densely populated with diverse microbial communities that are essential to health. Prebiotics and fiber have been shown to possess the ability to modulate the gut microbiota. One of the plants being considered as a potential source of prebiotic is yacon. Yacon is an underutilized plant consumed as a traditional root-based fruit in South America. Yacon mainly contains fructooligosaccharides (FOS) and inulin. Therefore, it has bifidogenic benefits for gut health, because FOS are not easily broken down by digestive enzymes...
April 12, 2018: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/29618337/gene-co-expression-networks-in-liver-and-muscle-transcriptome-reveal-sex-specific-gene-expression-in-lambs-fed-with-a-mix-of-essential-oils
#8
Marcella Sabino, Victor Adriano Okstoft Carmelo, Gianluca Mazzoni, Katia Cappelli, Stefano Capomaccio, Paolo Ajmone-Marsan, Andrea Verini-Supplizi, Massimo Trabalza-Marinucci, Haja N Kadarmideen
BACKGROUND: Essential oil (EO) dietary supplementation is a new strategy to improve animal health. EO compounds have antiparasitic, antimicrobial, antiviral, antimycotic, antioxidant and anti-inflammatory proprieties. Nutrigenomics investigations represent innovative approaches in understanding the relation between diet effect and gene expression related to the animal performance. Few nutrigenomics studies have used a high-throughput RNA-Sequencing (RNA-Seq) approach, despite great potential of RNA-Seq data in gene expression quantification and in co-expression network analyses...
April 4, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29590680/nutrigenomic-information-in-the-openehr-data-set
#9
Priscila Alves Maranhão, Gustavo Marísio Bacelar-Silva, Duarte Nuno Gonçalves Ferreira, Conceição Calhau, Pedro Vieira-Marques, Ricardo João Cruz-Correia
BACKGROUND:  The traditional concept of personalized nutrition is based on adapting diets according to individual needs and preferences. Discussions about personalized nutrition have been on since the Human Genome Project, which has sequenced the human genome. Thenceforth, topics such as nutrigenomics have been assessed to help in better understanding the genetic variation influence on the dietary response and association between nutrients and gene expression. Hence, some challenges impaired the understanding about the nowadays important clinical data and about clinical data assumed to be important in the future...
January 2018: Applied Clinical Informatics
https://www.readbyqxmd.com/read/29506909/vegf-and-glut1-are-highly-heritable-inversely-correlated-and-affected-by-dietary-fat-intake-consequences-for-cognitive-function-in-humans
#10
Rita Schüler, Nicole Seebeck, Martin A Osterhoff, Veronica Witte, Agnes Flöel, Andreas Busjahn, Alexander Jais, Jens C Brüning, Turid Frahnow, Stefan Kabisch, Olga Pivovarova, Silke Hornemann, Michael Kruse, Andreas F H Pfeiffer
OBJECTIVE: Reduction of brain glucose transporter GLUT1 results in severe neurological dysfunction. VEGF is required to restore and maintain brain glucose uptake across the blood brain barrier via GLUT1, which was shown to be acutely diminished in response to a high fat diet (HFD) in mice. The genetic and HFD-related regulation and association of VEGF and GLUT1 (SLC2A1) in humans was investigated in the NUtriGenomic Analysis in Twins (NUGAT) study. METHODS: 92 healthy and non-obese twins were standardized to a high-carbohydrate low-fat diet for 6 weeks before switched to a 6-week HFD under isocaloric conditions...
May 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29484031/-fto-genotype-dietary-protein-intake-and-body-weight-in-a-multiethnic-population-of-young-adults-a-cross-sectional-study
#11
David C Merritt, Joseph Jamnik, Ahmed El-Sohemy
Background: Variation in the fat mass and obesity-associated gene ( FTO ) has been associated with susceptibility to obesity, but the association appears to be modified by diet. We investigated whether dietary protein intake modifies the association between FTO variant rs1558902 and body mass index (BMI) and waist circumference in young adults ( n  = 1491) from the cross-sectional Toronto Nutrigenomics and Health Study. Results: Lifestyle, genetic, anthropometric, and biochemical data were collected and diet was assessed using a Toronto-modified Willett Food Frequency Questionnaire...
2018: Genes & Nutrition
https://www.readbyqxmd.com/read/29470410/the-evolving-role-of-multivitamin-multimineral-supplement-use-among-adults-in-the-age-of-personalized-nutrition
#12
REVIEW
Jeffrey B Blumberg, Regan L Bailey, Howard D Sesso, Cornelia M Ulrich
Micronutrient deficiencies occur in segments of the adult population in the United States. Multivitamin/multimineral supplements (MVMS) are widely used by this population, which reduces inadequacies in micronutrient intake, but the potential for exceeding tolerable upper intake levels in others should be considered. There are concerns associated with the excessive intake of certain nutrients, particularly folic acid, and potential untoward consequences. The advent of nutrigenomics and the enhanced ability to directly study the interactions between nutrition and genetic variants and expression will allow for the conduct of more targeted studies with specific endpoints and may ultimately lead to progress in the field of personalized nutrition...
February 22, 2018: Nutrients
https://www.readbyqxmd.com/read/29433995/precision-nutrition-for-prevention-and-management-of-type-2-diabetes
#13
REVIEW
Dong D Wang, Frank B Hu
Precision nutrition aims to prevent and manage chronic diseases by tailoring dietary interventions or recommendations to one or a combination of an individual's genetic background, metabolic profile, and environmental exposures. Recent advances in genomics, metabolomics, and gut microbiome technologies have offered opportunities as well as challenges in the use of precision nutrition to prevent and manage type 2 diabetes. Nutrigenomics studies have identified genetic variants that influence intake and metabolism of specific nutrients and predict individuals' variability in response to dietary interventions...
May 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29389608/nutrigenomic-studies-on-hilsa-to-evaluate-flesh-quality-attributes-and-genes-associated-with-fatty-acid-metabolism-from-the-rivers-hooghly-and-padma
#14
Satabdi Ganguly, Arabinda Mahanty, Tandrima Mitra, Sasmita Mohanty, Basanta Kumar Das, Bimal Prasanna Mohanty
The Indian shad hilsa (Tenualosa ilisha), a commercially important food fish rich in oils, enjoys high consumer preference in the South Asian countries owing to its unique flavour and culinary properties. The present study was undertaken with the primary objective of determining the flesh quality attributes of hilsa in terms of nutritive value (gross chemical composition, amino acid, fatty acid and mineral composition), pH, water holding capacity (WHC) and expression of genes associated with fatty acid metabolism and flesh quality...
January 2018: Food Research International
https://www.readbyqxmd.com/read/29365662/fetal-programming-and-nutrigenomics-different-response-of-female-progeny-versus-male-progeny-in-cholesterolemia-to-maternal-intake-of-fructose
#15
Paola Otero Gómez, Maite De La Cuesta, Elena Fauste, Silvia Rodrigo, Maribel Panadero, Juan José Alvarez-Millán, Lourdes Rodríguez, Carlos Bocos
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29355093/dietary-fat-intake-associated-with-bone-mineral-density-among-visfatin-genotype-in-obese-people
#16
Leila Khorrami-Nezhad, Khadijeh Mirzaei, Zhila Maghbooli, Seyed Ali Keshavarz
Osteoporosis and adipose tissue are closely related with many contradictions. Visfatin is an adipokine that is related to osteoporosis and adiposity. This nutrigenomics study examined the interaction between visfatin genotypes and dietary fat intake, with regard to bone mineral density (BMD) among an obese population. In this cross-sectional study, 336 subjects were enrolled; the mean age was 38·25 (sd 11·69) years and the mean BMI was 31·79 (sd 4·77) kg/m2. Laboratory measurements were lipid profile, insulin and fasting blood sugar...
January 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29339647/proceedings-of-the-11th-congress-of-the-international-society-of-nutrigenetics-and-nutrigenomics-isnn-2017
#17
William T Barrington, Anna C Salvador, Jaana A Hartiala, Raffaele De Caterina, Martin Kohlmeier, J Alfredo Martinez, Carin B Kreutzer, David Heber, Aldons J Lusis, Zhaoping Li, Hooman Allayee
The International Society of Nutrigenetics and Nutrigenomics (ISNN) held its 11th annual Congress in Los Angeles, California, between September 16 and 19, 2017. In addition to 2 keynote lectures, 4 plenary sessions included presentations by internationally renowned speakers on cutting-edge areas of research and new discoveries in genetics/genomics, the microbiome, and nutrition. Scientific topics included multi-omics approaches; diet and the microbiome; cancer, longevity, and metabolism; moving the field forward; and translational/educational aspects and the future of medicine...
2017: Journal of Nutrigenetics and Nutrigenomics
https://www.readbyqxmd.com/read/29316855/the-role-of-noninvasive-cardiovascular-testing-applied-clinical-nutrition-and-nutritional-supplements-in-the-prevention-and-treatment-of-coronary-heart-disease
#18
Mark Houston
Numerous clinical trials suggest that we have reached a limit in our ability to decrease the incidence of coronary heart disease (CHD) and cardiovascular disease (CVD) utilizing the traditional diagnostic evaluation, prevention and treatment strategies for the top five cardiovascular risk factors of hypertension, diabetes mellitus, dyslipidemia, obesity and smoking. About 80% of heart disease (heart attacks, angina, coronary heart disease and congestive heart failure) can be prevented by optimal nutrition, optimal exercise, optimal weight and body composition, mild alcohol intake and avoiding smoking...
March 2018: Therapeutic Advances in Cardiovascular Disease
https://www.readbyqxmd.com/read/29313752/recent-science-and-clinical-application-of-nutrition-to-coronary-heart-disease
#19
Mark Houston, Deanna Minich, Stephen T Sinatra, Joel K Kahn, Mimi Guarneri
One of the greatest threats to mortality in industrialized societies continues to be coronary heart disease (CHD). Moreover, the ability to decrease the incidence of CHD has reached a limit utilizing traditional diagnostic evaluations and prevention and treatment strategies for the top five cardiovascular risk factors (hypertension, diabetes mellitus, dyslipidemia, obesity, and smoking). It is well known that about 80% of CHD can be prevented with optimal nutrition, coupled with exercise, weight management, mild alcohol intake, and smoking cessation...
March 2018: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/29249178/biomarkers-of-cardiometabolic-health-and-nutritional-status-in-individuals-with-positive-celiac-disease-serology
#20
Joseph Jamnik, David Ja Jenkins, Ahmed El-Sohemy
BACKGROUND: Celiac disease (CD) is an autoimmune disorder characterized by damage to the intestinal mucosa and nutrient malabsorption in severe cases. However, it remains unclear whether nutrient deficiencies and other adverse health effects are prevalent in individuals with positive CD serology identified through screening studies. OBJECTIVE: The objective was to determine whether biomarkers of cardiometabolic health and nutritional status differ between those with positive and negative CD serology identified in a screening study of Canadian adults...
January 1, 2017: Nutrition and Health
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