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https://www.readbyqxmd.com/read/30325844/stenciling-based-prick-and-print-technique-for-harvesting-shaped-corneal-grafts-for-management-of-peripheral-corneal-perforations
#1
Gautam Singh Parmar, Bhushan Ghodke, Sunandini Bose, Ashok Kumar Meena
PURPOSE: To evaluate a new surgical technique ("prick and print") for harvesting shaped donor corneal grafts in cases with perforated peripheral ulcerative keratitis (PUK). METHODS: We conducted a retrospective case series at a tertiary center. Medical records of 13 patients with perforated PUK, who underwent tectonic eccentric keratoplasty using the stenciling-based prick and print technique during the past 1 year, were reviewed. All patients (15 eyes of 13 patients) received grafts of varying sizes and shapes (14 crescentic and 1 biconvex)...
October 5, 2018: Cornea
https://www.readbyqxmd.com/read/30325492/ophtalmoplegia-complicating-sino-orbital-mucormycosis
#2
Walid Zbiba, Emna Bouayed, Nadia Ben Abdesslem, Issam Elleuch, Malek Kharrat
PURPOSE: To report a case of complete ophthalmoplegia and blindness in sino-orbital mucormycosis. CASE REPORT: A 68-year-old woman with history of diabetes and breast cancer presented with sudden onset of fever, orbital pain and blindness in the right eye. The patient was found to have no light perception, complete ophthalmoplegia, chemosis, corneal ulcer and optic nerve atrophy. In rhinologic examination, necrosis was noticed. Brain and orbit magnetic resonance imaging showed diffuse sinusitis with orbital involvement...
March 2018: La Tunisie Médicale
https://www.readbyqxmd.com/read/30324322/genetic-diversity-and-persistent-colonization-of-enterococcus-faecalis-on-ocular-surfaces
#3
Daisuke Todokoro, Hiroshi Eguchi, Takashi Suzuki, Motoo Suzuki, Haruyuki Nakayama-Imaohji, Tomomi Kuwahara, Takahiro Nomura, Haruyoshi Tomita, Hideo Akiyama
PURPOSE: Enterococcus faecalis causes severe acute endophthalmitis and often leads to poor visual outcomes. Conjunctival bacterial cultures occasionally grow atypical bacteria including E. faecalis, which can potentially contribute to the development of postoperative endophthalmitis. However, the characteristics of these ocular E. faecalis strains are unknown. This study is the first attempt to determine the population characteristics of E. faecalis clinical isolates from eye infections and ocular commensals...
October 15, 2018: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/30317274/severe-haemolysis-and-renal-failure-precipitated-by-hepatitis-e-virus-in-g6pd-deficient-patient-a-case-report
#4
Baseer Sultan Ahmad, Adeel Ahmad, Sajjad Jamil, Saiyed Abdullah Abubakar Mohsin Ehsanullah, Abeera Munir
Hepatitis E virus is the etiological agent for Hepatitis E infection, which is congruent to Hepatitis A infection. The clinical spectrum of the disease range from asymptomatic self-limiting disease which requires no treatment to life threatening fulminant liver disease in pregnancy, G6PD deficient and post-liver transplant patients, which necessitate urgent treatment. Similarly we are reporting a case of a 28 year old male with no previous known comorbids, who presented in emergency department with low grade fever, yellow discolouration of eyes and upper abdominal pain for last 5-6 days...
September 2018: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/30317199/toxic-epidermal-necrolysis-the-red-eye-and-red-herrings-in-casualty
#5
Robert J Barry, Ulises Zanetto, Sai Kolli, Rupal Morjaria
A 38-year-old woman presented to casualty with bilateral red eyes associated with a recent upper respiratory tract infection. This was initially diagnosed as conjunctivitis, however systemic review revealed an erythematous facial and skin rash, mildly swollen lips and mild swallowing difficulties. The patient was referred for an urgent medical assessment, by which time she was found to have erythema affecting 54% of her body surface area and diagnosed with suspected toxic epidermal necrolysis (TEN). She rapidly deteriorated over 24 hours with a spreading blistering skin rash and airway compromise requiring urgent intubation and admission to the intensive treatment unit (ITU)...
October 12, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/30317007/pathogenesis-of-herpes-simplex-keratitis-the-host-cell-response-and-ocular-surface-sequelae-to-infection-and-inflammation
#6
REVIEW
Ann-Marie Lobo, Alex M Agelidis, Deepak Shukla
Herpes simplex virus type 1 (HSV) keratitis is a leading cause of infectious blindness. Clinical disease occurs variably throughout the cornea from epithelium to endothelium and recurrent HSV stromal keratitis is associated with corneal scarring and neovascularization. HSV keratitis can be associated with ocular pain and subsequent neutrophic keratopathy. Host cell interactions with HSV trigger an inflammatory cascade responsible not only for clearance of virus but also for progressive corneal opacification due to inflammatory cell infiltrate, angiogenesis, and corneal nerve loss...
October 11, 2018: Ocular Surface
https://www.readbyqxmd.com/read/30316219/comparison-of-chlorhexidine-disinfectant-in-vitro-effect-on-environmental-and-ocular-acanthamoeba-strains-the-amoebic-agents-of-human-keratitis-%C3%A2-an-emerging-sight-threatening-corneal-disease-in-poland
#7
Marcin Padzik, Wanda Baltaza, Jacek P. Szaflik, Edyta Hendiger, Monika Dybicz, Lidia Chomicz
Small amoebae belonging to the Acanthamoeba genus complete their life cycles in different environmental niches as free-living protists however some of them are facultative parasites that can cause severe disease in humans. The sight-threatening Acanthamoeba keratitis develops in immune-competent persons, mainly in contact lens wearers; it is detected with increasing frequency along with the spread of contact lens use. The high abundance of the amoebae in the environment is important for dispersion and transmission of the infections among humans...
2018: Annals of Parasitology
https://www.readbyqxmd.com/read/30315893/identification-of-sparganosis-based-on-next-generation-sequencing
#8
Bailu Du, Yue Tao, Jing Ma, Xing Weng, Yanping Gong, Yang Lin, Nan Shen, Xi Mo, Qing Cao
The incidence of sparganosis, a parasitic disease caused by plerocercoid larvae of the genus Spirometra, has gradually risen worldwide (especially in remote areas) in recent years. Pulmonary and pleural sparganosis, as well as other sites of infestation, including the subcutaneous tissues, the abdominal viscera, brain and eyes, has been reported. In clinical practice, due to the atypical signs and symptoms and limited laboratory approaches for the specific detection of sparganum, sparganosis is often misdiagnosed...
October 10, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/30315260/enucleation-in-asian-indian-patients-a-histopathological-review-of-2009-cases
#9
Swathi Kaliki, Sai Divya Jajapuram, Kavya Madhuri Bejjanki, George Ramappa, Ashik Mohamed, Dilip K Mishra
OBJECTIVE: To review the indications of enucleation in Asian Indian patients and study the trend over the 22-year period. METHODS: Retrospective study of 2009 patients who underwent enucleation. RESULTS: The mean age at presentation of patients who underwent enucleation was 155 months The histopathology diagnosis included a benign tumor (n = 22, 1%), malignant tumor (n = 1472, 73%), acute trauma (n = 93, 5%), retinal vascular disease (n = 50, 3%), inflammatory/infective pathology (n = 33, 2%), or other miscellaneous/non-specific diagnosis (n = 460, 23%)...
October 12, 2018: Eye
https://www.readbyqxmd.com/read/30314752/intracapsular-infection-after-small-incision-lenticule-extraction
#10
Min Chen, Dewei Li
A 40-year-old man had uneventful small-incision lenticule extraction. Three days later, the uncorrected distance visual acuity was 20/20 and the cornea was clear without intraocular inflammatory in both eyes. At 6 days, the patient presented with a foreign-body sensation in the right eye but with no decrease in vision. Dense infiltration was visible at the inferior nasal corneal rim on slitlamp microscopy. Anterior segment optical coherence tomography showed the lesion in the junction of the capsular bag and the lenticular edge...
October 9, 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/30311533/effects-of-topical-ophthalmic-application-of-0-5-proparacaine-hydrochloride-on-aerobic-bacterial-culture-results-for-naturally-occurring-infected-corneal-ulcers-in-dogs
#11
Katelyn E Fentiman, Amy J Rankin, Jessica M Meekins, James K Roush
OBJECTIVE To evaluate the effects of topical ophthalmic application of 0.5% proparacaine hydrochloride solution (PHCL; containing 0.01% benzalkonium chloride as preservative) on aerobic bacterial culture results for naturally occurring infected corneal ulcers in dogs. DESIGN Clinical trial. ANIMALS 25 client-owned dogs with infected corneal ulcers (24 unilaterally affected and 1 bilaterally affected; only 1 eye included/dog) examined between June 2008 and May 2011. PROCEDURES Swab samples for aerobic bacterial culture were collected from the periphery of each corneal ulcer before and approximately 1 minute after topical ophthalmic application of 1 drop of PHCL...
November 1, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/30308675/sinusitis-in-children
#12
Harbir Singh Arora
Acute bacterial sinusitis (ABS) mostly occurs as a complication of acute viral upper respiratory tract infection (URI), which is a common condition encountered in an outpatient setting. ABS manifests with three different presentations, most commonly as persistent symptoms of viral URI (nasal drainage and or cough) for more than 10 days. ABS is also diagnosed when the patient presents with severe symptoms of a URI accompanied by fever >102.2°F and purulent nasal drainage for at least 3 days. Lastly, ABS can complicate viral URI around day 6 or 7 of illness after initial improvement in the symptoms of URI...
October 1, 2018: Pediatric Annals
https://www.readbyqxmd.com/read/30307777/immune-response-and-mechanisms-of-ifn-%C3%AE-in-administration-for-keratomycosis
#13
Xuedong Zheng, Tianlu Xie, Yan Lin, Juan Yang, Libin Huang, Jingjin Zhang, Xiaoli Han, Jianzhang Hu
PURPOSE: To investigate the immune response and mechanisms of interferon-γ (IFN-γ) in the fungal keratitis in mice. METHODS: Mice were divided into two groups: group A, topical PBS four times daily post-infection; group B: topical IFN-γ four times daily post-infection. At1, 3, 5, and 7 days, the corneal lesions and inflammatory responses were observed by slit lamp, and immunofluorescence staining was performed to evaluate F4/80+ and CD4+ cells. Using ELISA, and RT-PCR to detect the expression levels of macrophage migration inhibitory factor (MIF), macrophage inflammatory protein-2 (MIP-2), IL-4, IL-10, IL-12, and IFN-γ...
October 11, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/30306361/endogenous-endophthalmitis-a-9-year-retrospective-study-at-a-tertiary-referral-hospital-in-malaysia
#14
Rosiah Muda, Valarmathy Vayavari, Deivanai Subbiah, Hamisah Ishak, Azian Adnan, Shelina Oli Mohamed
BACKGROUND: The objective of this study was to determine the clinical presentation, systemic risk factors, source of infective microorganism, treatment outcomes, and prognostic indicators of endogenous endophthalmitis at a main tertiary referral hospital for uveitis in Malaysia. A retrospective review of medical records of 120 patients (143 eyes) with endogenous endophthalmitis over a period of 9 years between January 2007 and December 2015 was undertaken. RESULTS: Identifiable systemic risk factors were present in 79...
October 11, 2018: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/30295071/immune-keratitis-an-unusual-primary-presentation-of-neuro-beh%C3%A3-et-s-disease
#15
Jitender Jinagal, Aniruddha Agarwal, Avinash Negi, Gaurav Gupta, Vikas Sharma, Parul Chawla Gupta, Jagat Ram
A 19-year-old Nepalese male presented with complaints of bilateral ocular discomfort, photophobia, watering, and redness for 1 week. Visual acuity was 6/12 and 6/60 in the right and left eye, respectively. On biomicroscopic examination, presence of peripheral stromal infiltrates with conjunctival follicles was noted; infiltrates progressed to involve central cornea with further decrease in vision over next few days. After ruling out infectious keratitis, detailed systemic examination and laboratory investigations were diagnostic of neuro-Behçet's disease...
October 7, 2018: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/30293205/multimodal-imaging-of-multifocal-chorioretinitis-secondary-to-endogenous-candida-infection
#16
Chiara Veronese, Chiara Maiolo, Annalisa Gurreri, Mariachiara Morara, Antonio P Ciardella, Lawrence A Yannuzzi
PURPOSE: To present multimodal imaging of multifocal chorioretinitis secondary to endogenous candida infection in a young adult. METHODS: A 49-year-old woman who presented for evaluation of bilateral endogenous candida chorioretinitis underwent complete ophthalmic examination, in addition to fundus photography (FP), enhanced depth imaging optical coherence tomography, fundus autofluorescence (FAF), fluorescein angiography (FA), indocyanine green angiography (ICGA) and optical coherence tomography angiography (OCTA)...
October 6, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/30290600/manifestations-and-outcomes-of-nocardia-infections-comparison-of-immunocompromised-and-nonimmunocompromised-adult-patients
#17
COMPARATIVE STUDY
Julie Steinbrink, Joan Leavens, Carol A Kauffman, Marisa H Miceli
Nocardia is a ubiquitous environmental pathogen that causes infection primarily following inhalation into the lungs. It is generally thought to cause infection primarily in immunocompromised patients, but nonimmunocompromised individuals are also at risk of infection. We sought to compare risk factors, clinical manifestations, diagnostic approach, treatment, and mortality in immunocompromised and nonimmunocompromised adults with nocardiosis.We studied all adults with culture-proven Nocardia infection at a tertiary care hospital from 1994 to 2015 and compared immunocompromised with nonimmunocompromised patients...
October 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30289395/the-evaluation-of-the-effect-of-helicobacter-pylori-infection-on-choroidal-thickness
#18
Cemile Üçgül Atılgan, Ahmet Yozgat, Pınar Kösekahya, Mehtap Çağlayan, Selam Yekta Şendul, Nilüfer Berker, Zeynep Altıparmak, Emin Altıparmak, Pelin Yılmazbaş
BACKGROUND/AIMS: To evaluate the effects of Helicobacter pylori infection on choroidal thickness (CT) using enhanced depth imaging spectral domain-optical coherence tomography (SD-OCT). MATERIALS AND METHODS: A total of 63 right eyes of 63 patients who tested positive for H. pylori (Group 1) and 46 right eyes of 46 patients who tested negative for H. pylori (Group 2) were evaluated. The CTs at the subfoveal area and at 1 mm ranging up to 3 mm from the fovea at the nasal and temporal quadrants were measured and compared...
October 5, 2018: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/30287322/more-than-keratitis-ichthyosis-and-deafness-multisystem-effects-of-lethal-gjb2-mutations
#19
Evelyn Lilly, Christopher G Bunick, Alexander M Maley, Shali Zhang, Mary K Spraker, Amy J Theos, Karina L Vivar, Lucia Seminario-Vidal, Adam E Bennett, Robert Sidbury, Yasushi Ogawa, Masashi Akiyama, Barbara Binder, Smail Hadj-Rabia, Raffaella A Morotti, Earl J Glusac, Keith A Choate, Gabriele Richard, Leonard M Milstone
BACKGROUND: Infant death in KID syndrome is recognized; its association with specific genotypes and pathophysiology is inadequately understood. OBJECTIVE: To discover characteristics that account for poor outcomes in lethal KID syndrome. METHODS: We collected four new cases and nine previously reported, genotyped cases of lethal KID syndrome. We performed new molecular modeling of the lethal mutants GJB2 p.A88V and GJB2 p.G45E. RESULTS: Infant death occurred in all patients with GJB2 p...
October 1, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/30286145/tracheal-tubes-lubricated-with-water-to-reduce-sore-throat-after-intubation-a-randomized-non-inferiority-trial
#20
Eugene Kim, Seong Mi Yang, Sang Gyu Kwak, Seoyeong Park, Jae-Hyon Bahk, Jeong-Hwa Seo
BACKGROUND: Sore throat is common after tracheal intubation. Water can be used to lubricate tracheal tubes, but its benefit has not been validated. We thus did a randomised non-inferiority trial to test the hypothesis that a tube lubricated with water does not reduce sore throat after tracheal intubation. METHODS: We randomized female or male patients (n = 296) undergoing surgery in the ears or eyes to receive either a tube lubricated with water or a tube without lubrication for intubation...
2018: PloS One
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