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Abnormal placentation

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https://www.readbyqxmd.com/read/30339608/contributors-management-of-abnormal-placentation
#1
(no author information available yet)
No abstract text is available yet for this article.
December 2018: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/30337910/zika-virus-infection-at-different-pregnancy-stages-anatomopathological-findings-target-cells-and-viral-persistence-in-placental-tissues
#2
Lucia de Noronha, Camila Zanluca, Marion Burger, Andreia Akemi Suzukawa, Marina Azevedo, Patricia Z Rebutini, Iolanda Maria Novadzki, Laurina Setsuko Tanabe, Mayra Marinho Presibella, Claudia Nunes Duarte Dos Santos
Zika virus (ZIKV) infection in humans has been associated with congenital malformations and other neurological disorders, such as Guillain-Barré syndrome. The mechanism(s) of ZIKV intrauterine transmission, the cell types involved, the most vulnerable period of pregnancy for severe outcomes from infection and other physiopathological aspects are not completely elucidated. In this study, we analyzed placental samples obtained at the time of delivery from a group of 24 women diagnosed with ZIKV infection during the first, second or third trimesters of pregnancy...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/30335256/-asherman-s-syndrome-management-after-curettage-following-a-postnatal-placental-retention-and-literature-review
#3
REVIEW
Nguefack C Tchente, G Brichant, M Nisolle
Asherman's syndrome (AS) is a partial or complete obliteration of the uterine cavity after intrauterine trauma. Approximately 90 % of severe AS cases occur after abortion curettage or postpartum curettage. Clinical signs and symptoms are abnormalities of the cycle (hypomenorrhoea or amenorrhoea) and fertility disorders. We have reviewed the recent literature on AS following the description of a typical clinical case. The management of AS is not easy. It must be done by experienced surgeons. Realization of several surgeries is sometimes mandatory, with the use of anti-adhesive devices between interventions...
October 2018: Revue Médicale de Liège
https://www.readbyqxmd.com/read/30335019/choriocarcinoma-with-brain-metastasis-after-term-pregnancy-a-case-report
#4
Liang Song, Qingli Li, Rutie Yin, Danqing Wang
RATIONALE: Although the incidence of postpartum choriocarcinoma is extremely low, careful postpartum placental examination, histopathological examination in patients with abnormalities, and blood β-human chorionic gonadotropin (HCG) monitoring in high-risk pregnant women are necessary for early diagnosis of postpartum choriocarcinoma and improvement in prognosis. PATIENT CONCERNS: A 32-year-old woman presented with the chief complaint of postpartum irregular vaginal bleeding for 45 days and coughing and hemoptysis for 7 days...
October 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30334300/maternal-right-ventricular-function-uteroplacental-circulation-in-first-trimester-and-pregnancy-outcome-in-women-with-congenital-heart-disease
#5
Anne S Siegmund, Marlies A M Kampman, Martijn A Oudijk, Barbara J M Mulder, Gertjan Tj Sieswerda, Steven V Koenen, Yoran M Hummel, Monique W M de Laat, Krystyna M Sollie-Szarynska, Henk Groen, Arie P J van Dijk, Dirk J van Veldhuisen, Caterina M Bilardo, Petronella G Pieper
OBJECTIVE: Pregnant women with congenital heart disease (CHD) have an increased chance of abnormal uteroplacental flow (UPF) measured from second trimester onwards. This is related to pregnancy complications affecting mother and baby. Maternal right ventricular (RV) dysfunction has been suggested as predisposing factor. First trimester UPF screening, followed by therapeutic strategies, is effective in preventing pregnancy complications. The study aim was to relate first trimester UPF measurements to pre-pregnancy maternal cardiac function and pregnancy complications...
October 17, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/30325659/improving-pregnancy-outcomes-in-humans-through-studies-in-sheep
#6
Janna L Morrison, Mary J Berry, Kimberley Jae Botting, Jack R T Darby, Martin G Frasch, Kathryn L Gatford, Dino A Giussani, Clint Lee Gray, Richard Harding, Emilio A Herrera, Matthew W Kemp, Mitchell C Lock, I Caroline McMillen, Timothy J Moss, Gabrielle C Musk, Mark H Oliver, Timothy R H Regnault, Claire T Roberts, Jia Yin Soo, Ross L Tellam
Experimental studies that are relevant to human pregnancy rely on the selection of appropriate animal models as an important element in experimental design. Consideration of the strengths and weaknesses of any animal model of human disease is fundamental to effective and meaningful translation of preclinical research. Studies in sheep have made significant contributions to our understanding of the normal and abnormal development of the fetus. As a model of human pregnancy, studies in sheep have enabled scientists and clinicians to answer questions about the etiology and treatment of poor maternal, placental and fetal health and to provide an evidence base for translation of interventions into the clinic...
October 16, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/30322585/short-term-and-long-term-effects-of-caesarean-section-on-the-health-of-women-and-children
#7
REVIEW
Jane Sandall, Rachel M Tribe, Lisa Avery, Glen Mola, Gerard Ha Visser, Caroline Se Homer, Deena Gibbons, Niamh M Kelly, Holly Powell Kennedy, Hussein Kidanto, Paul Taylor, Marleen Temmerman
A caesarean section (CS) can be a life-saving intervention when medically indicated, but this procedure can also lead to short-term and long-term health effects for women and children. Given the increasing use of CS, particularly without medical indication, an increased understanding of its health effects on women and children has become crucial, which we discuss in this Series paper. The prevalence of maternal mortality and maternal morbidity is higher after CS than after vaginal birth. CS is associated with an increased risk of uterine rupture, abnormal placentation, ectopic pregnancy, stillbirth, and preterm birth, and these risks increase in a dose-response manner...
October 13, 2018: Lancet
https://www.readbyqxmd.com/read/30320188/the-metabolic-role-of-lnczbtb39-1-2-in-the-trophoblast-mobility-of-preeclampsia
#8
Yamin Liu, Ting-Li Han, Xiaofang Luo, Yuxiang Bai, Xuehai Chen, Wei Peng, Xi Xiong, Philip N Baker, Chao Tong, Hongbo Qi
Preeclampsia is characterized by new onset of hypertension and proteinuria after 20 weeks' gestation and is a leading cause of maternal and neonatal morbidity and mortality. The pathogenesis of preeclampsia is often associated with aberrant trophoblast function that leads to shallow placental implantation. However, the exact underlying mechanisms remain unclear. Placental LncZBTB39-1:2 expression level was investigated in 20 healthy placentae and 20 placentae with preeclampsia using qRT-PCR, and the metabolic profile of trophoblasts overexpressing LncZBTB39-1:2 in vitro was analysed using gas chromatography-mass spectrometry (GC-MS)...
September 2018: Genes & Diseases
https://www.readbyqxmd.com/read/30319761/hydrogen-rich-water-ameliorates-rat-placental-stress-induced-by-water-restriction
#9
Yun-Zhi Shi, Song Jin, Han Qin, Heng-Bo Jiang, Guo-Hua Song, Shu-Cun Qin
Dehydration is one of the intrauterine abnormalities that could lead to fetal growth retardation and to increase the risk of a variety of adult diseases later in life. This study were to determine the impact of hydrogen-rich water (HRW) supplementation on placental angiotensin II type 1 receptor and placental oxidative stress induced by water restriction. Pregnant Wistar rat were randomly assigned to one of the three groups ( n =12 per group). In control group, pure water and food were supplied ad libitum. Water restriction group and HRW group were respectively given pure water and HRW with free access to food, excepting only one hour was available for drinking from day 7 to day 17 of pregnancy...
July 2018: Medical Gas Research
https://www.readbyqxmd.com/read/30319550/regulation-of-placental-development-and-its-impact-on-fetal-growth-new-insights-from-mouse-models
#10
REVIEW
Laura Woods, Vicente Perez-Garcia, Myriam Hemberger
The placenta is the chief regulator of nutrient supply to the growing embryo during gestation. As such, adequate placental function is instrumental for developmental progression throughout intrauterine development. One of the most common complications during pregnancy is insufficient growth of the fetus, a problem termed intrauterine growth restriction (IUGR) that is most frequently rooted in a malfunctional placenta. Together with conventional gene targeting approaches, recent advances in screening mouse mutants for placental defects, combined with the ability to rapidly induce mutations in vitro and in vivo by CRISPR-Cas9 technology, has provided new insights into the contribution of the genome to normal placental development...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/30317546/abnormally-invasive-placentation-in-cohort-studies-refining-the-methodology
#11
Gabriel Levin, Amihai Rottenstreich
We read the original research by Martimucci et al. with great interest (1). They performed a retrospective cohort study evaluating the role of a short interpregnancy interval (IPI) in the occurrence abnormal invasive placentation (AIP). In their study, 67 women were included in the study group and 86 in the control group. The authors concluded that short IPI is not associated with increased risk of AIP. While the authors address an important topic, several important issues warrant further clarification. This article is protected by copyright...
October 14, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/30316326/the-role-of-placental-malperfusion-in-the-pathogenesis-of-preeclampsia-in-dichorionic-twin-and-singleton-pregnancies
#12
Amir Aviram, Ms Kristine Giltvedt, Christopher Sherman, John Kingdom, Arthur Zaltz, Jon Barrett, Nir Melamed
INTRODUCTION: In singletons, the pathogenesis of hypertensive disorders of pregnancy (HDP) is attributed to abnormal placentation, characterized by maternal vascular malperfusion (MVM) lesions. Whether MVM plays a similar role in twin pregnancies is unclear. The purpose of the study was to compared placental pathology findings between dichorionic-twin and singleton pregnancies complicated by HDP. METHODS: Retrospective cohort study of women with dichorionic-twin or singleton pregnancies complicated by HDP who gave birth in a single tertiary center between 2001 and 2015...
October 2018: Placenta
https://www.readbyqxmd.com/read/30315787/fetal-growth-and-risk-assessment-is-there-an-impasse
#13
Jason Gardosi
Fetal growth restriction is an indicator of placental insufficiency and is strongly associated with adverse perinatal outcome. There is a point that the recent dominance in the medical literature about which reference charts to use and dichotomization of fetal size at the 10th percentile overlooks the fact there is not a single cut-off in any growth chart that acts as an absolute divider between high and low risk for adverse outcome. Thus, the collective goal of all researchers to identify, monitor and effectively manage growth-restricted fetuses is better served by replacing dichotomisation of normal versus abnormal fetal growth at the 10th percentile by interpretation of fetal size in context with other known parameters of fetal risk - all as continuous parameters...
October 10, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/30315784/fetal-growth-and-risk-assessment-is-there-an-impasse
#14
Wessel Ganzevoort, Baskaran Thilaganathan, Ahmet Baschat, Sanne Gordijn
Fetal growth restriction is an indicator of placental insufficiency and is strongly associated with adverse perinatal outcome. There is a point that the recent dominance in the medical literature about which reference charts to use and dichotomization of fetal size at the 10th percentile overlooks the fact there is not a single cut-off in any growth chart that acts as an absolute divider between high and low risk for adverse outcome. Thus, the collective goal of all researchers to identify, monitor and effectively manage growth-restricted fetuses is better served by replacing dichotomisation of normal versus abnormal fetal growth at the 10th percentile by interpretation of fetal size in context with other known parameters of fetal risk - all as continuous parameters...
October 10, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/30315766/ap39-a-modulator-of-mitochondrial-bioenergetics-reduces-anti-angiogenic-response-and-oxidative-stress-in-hypoxia-exposed-trophoblasts-relevance-for-preeclampsia-pathogenesis
#15
Ambart E Covarrubias, Edouard Lecarpentier, Agnes Lo, Saira Salahuddin, Kathryn J Gray, S Ananth Karumanchi, Zsuzsanna K Zsengellér
Although the etiology of preeclampsia, a pregnancy complication with significant maternal and neonatal morbidity, has not been fully characterized, placental ischemia due to impaired spiral artery remodeling and abnormal secretion of anti-angiogenic factors are thought to be important in the pathogenesis of the disease. Placental ischemia could impair trophoblast mitochondrial function and energy production leading to the release of reactive oxygen species (ROS). ROS has been shown to stabilize hypoxia inducible factor (HIF-1α), which in turn may induce transcription of anti-angiogenic factors, soluble fms-like tyrosine kinase 1 (sFLT1) and soluble endoglin in trophoblasts...
October 10, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/30312189/foreword-management-of-abnormal-placentation
#16
Robert M Silver
No abstract text is available yet for this article.
December 2018: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/30308389/cortisol-progesterone-17%C3%AE-ohprogesterone-and-pregnenolone-in-foals-born-from-mare-s-hormone-treated-for-experimentally-induced-ascending-placentitis
#17
Vitória Müller, Bruna R Curcio, Ramiro E Toribio, Lorena S Feijó, Luciana A Borba, Igor F Canisso, Carlos E W Nogueira
This study aimed to evaluate steroid hormones in foals born from mares treated for ascending placentitis with different combinations of trimethoprim-sulfamethoxazole (TMS), flunixin meglumine (FM), long-acting altrenogest (ALT) and estradiol cypionate (ECP) for ten consecutive days, starting two days after experimental induction of placentitis with Streptococcus zooepidemicus. Fourty-six pregnant mares and respective foals were assigned as healthy group (Control, n = 8) or treated groups as follows: TMS+FM (n = 8), TMS+FM+ALT (n = 8), TMS+FM+ALT+ECP (n = 6), TMS+FM+ECP (n = 6) and no treatment (NO TREAT n = 10)...
June 30, 2018: Theriogenology
https://www.readbyqxmd.com/read/30303745/bisphenol-a-exposure-alters-placentation-and-causes-preeclampsia-like-features-in-pregnant-mice-involved-in-reprogramming-of-dna-methylation-of-wnt2
#18
Yunzhen Ye, Yao Tang, Yu Xiong, Liping Feng, Xiaotian Li
Preeclampsia leads to adverse outcomes for pregnant women. Bisphenol A (BPA) is an environmental endocrine disruptor and has been shown to be positively associated with increased risk of preeclampsia in human studies. We investigated whether BPA exposure causes preeclampsia-like features in pregnant mice and the associated underlying mechanisms. Experiments were performed in animal models and cell cultures. In pregnant mice, BPA-exposed mice exhibited preeclampsia-like features including hypertension, disruption of the circulation, and the placental angiogenesis biomarkers fms-related tyrosine kinase 1 and placenta growth factor, and glomerular atrophy; urinary protein was not affected...
October 10, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/30291324/first-trimester-placental-endothelial-cells-from-pregnancies-with-abnormal-uterine-artery-doppler-are-more-sensitive-to-apoptotic-stimuli
#19
Nicoletta Charolidi, Amanda J Host, Sandra Ashton, Zoe Tryfonos, Karin Leslie, Baskaran Thilaganathan, Judith E Cartwright, Guy S Whitley
Failure of the placental capillary network to develop normally is associated with early onset fetal growth restriction (FGR) and pre-eclampsia (PE). Although the symptoms are observed at term, the problem begins in the first trimester. However, investigations at this clinically relevant time are hindered by difficulties in identifying earlystage pregnancies that are at risk of developing FGR/PE. Using uterine artery Doppler ultrasound in the first trimester as a proxy measure of poor placentation, we have identified pregnancies at increased risk of developing early onset FGR/PE...
October 5, 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/30288733/interpregnancy-interval-and-abnormally-invasive-placentation
#20
Kristina Martimucci, Robyn Bilinski, Anisha M Perez, Theresa Kuhn, Abdulla Al-Khan, Jesus R Alvarez-Perez
INTRODUCTION: The presence of a previous uterine scar is a strong risk factor for developing abnormally invasive placentation (AIP). We sought to determine if a short interpregnancy interval predisposes to AIP. We hypothesized that short interpregnancy interval after a previous cesarean delivery increase the risk of AIP in comparison to a longer interpregnancy interval. MATERIAL AND METHODS: We performed a retrospective cohort study of women with a histological diagnosis of AIP and a history of a previous cesarean section...
October 4, 2018: Acta Obstetricia et Gynecologica Scandinavica
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