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Angiogenic factors

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https://www.readbyqxmd.com/read/30343555/angiogenesis-focusing-on-the-effects-of-exercise-in-aging-and-cancer
#1
Seong-Eun Kwak, Ji-Hyun Lee, Didi Zhang, Wook Song
PURPOSE: Although it is known that exercise induces angiogenesis, a clear mechanism has remained elusive due to various experimental limitations. This review presents the current status of angiogenesis-related experiments and future directions of experimentation in relation to exercise, aging, and cancer. METHODS: We conducted a PubMed search of the available literature to identify reported exercise related changes of angiogenic factors obtained in vitro using C2C12 cells and endothelial cells, and in vivo using animal experiments and in clinical studies...
September 30, 2018: Journal of Exercise Nutrition & Biochemistry
https://www.readbyqxmd.com/read/30343252/improving-the-angiogenic-potential-of-epcs-via-engineering-with-synthetic-modified-mrnas
#2
Heidrun Steinle, Sonia Golombek, Andreas Behring, Christian Schlensak, Hans Peter Wendel, Meltem Avci-Adali
The application of endothelial progenitor cells (EPCs) for the revascularization of ischemic tissues, such as after myocardial infarction, stroke, and acute limb ischemia, has a huge clinical potential. However, the low retention and engraftment of EPCs as well as the poor survival of migrated stem cells in ischemic tissues still hamper the successful clinical application. Thus, in this study, we engineered, for the first time, murine EPCs with synthetic mRNAs to transiently produce proangiogenic factors vascular endothelial growth factor-A (VEGF-A), stromal cell-derived factor-1α (SDF-1α), and angiopoietin-1 (ANG-1)...
September 13, 2018: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/30342159/methylglyoxal-accumulation-de-regulates-hoxa5-expression-thereby-impairing-angiogenesis-in-glyoxalase-1-knock-down-mouse-aortic-endothelial-cells
#3
Cecilia Nigro, Alessia Leone, Michele Longo, Immacolata Prevenzano, Thomas H Fleming, Antonella Nicolò, Luca Parrillo, Rosa Spinelli, Pietro Formisano, Peter P Nawroth, Francesco Beguinot, Claudia Miele
Impaired angiogenesis leads to long-term complications and is a major contributor of the high morbidity in patients with Diabetes Mellitus (DM). Methylglyoxal (MGO) is a glycolysis byproduct that accumulates in DM and is detoxified by the Glyoxalase 1 (Glo1). Several studies suggest that MGO contributes to vascular complications through mechanisms that remain to be elucidated. In this study we have clarified for the first time the molecular mechanism involved in the impairment of angiogenesis induced by MGO accumulation...
October 17, 2018: Biochimica et biophysica acta. Molecular basis of disease
https://www.readbyqxmd.com/read/30340815/a-high-sucrose-diet-does-not-enhance-spontaneous-metastasis-of-lewis-lung-carcinoma-in-mice
#4
Lin Yan, Sneha Sundaram
A high energy intake contributes to obesity, a risk factor for cancer. We previously reported that an excessive intake of dietary fat enhances malignant spread in mice. This study tested the hypothesis that consumption of a diet with an excessive amount of sucrose enhances metastasis. In a spontaneous metastasis model of Lewis lung carcinoma (LLC), male C57BL/6 mice were maintained on an AIN93G, a high-fat, or a high-sucrose diet for the duration of the study. Pulmonary metastases from a primary tumor, established by a subcutaneous injection of LLC cells, were quantified...
October 2018: Nutrition Research
https://www.readbyqxmd.com/read/30338879/molecular-determinants-of-microvascular-dysfunction-in-hypertensive-pregnancy-and-preeclampsia
#5
Wentao Yu, Wei Gao, Dan Rong, Zhixian Wu, Raouf A Khalil
Preeclampsia is a pregnancy-related disorder characterized by hypertension and often fetal intrauterine growth restriction, but the underlying mechanisms are unclear. Defective placentation and apoptosis of invasive cytotrophoblasts cause inadequate remodeling of spiral arteries, placental ischemia and reduced uterine perfusion pressure (RUPP). RUPP causes imbalance between the anti-angiogenic factors soluble fms-like tyrosine kinase-1 and soluble endoglin and the pro-angiogenic vascular endothelial growth factor and placental growth factor, and stimulates the release of proinflammatory cytokines, hypoxia-inducible factor, reactive oxygen species, and angiotensin AT1 receptor agonistic autoantibodies...
October 19, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/30338719/co-delivery-of-deferoxamine-and-hydroxysafflor-yellow-a-to-accelerate-diabetic-wound-healing-via-enhanced-angiogenesis
#6
Si-Qian Gao, Chen Chang, Jun-Jun Li, Ying Li, Xiao-Qian Niu, Dan-Ping Zhang, Long-Jian Li, Jian-Qing Gao
Nonhealing chronic wounds on foot induced by diabetes is a complicated pathologic process. They are mainly caused by impaired neovascularization, neuropathy, and excessive inflammation. A strategy, which can accelerate the vessel network formation as well as inhibit inflammatory response at the same time, makes it possible for effective diabetic ulcers treatment. Co-delivery of multiple drugs with complementary bioactivity offers a strategy to properly treat diabetic wound. We previously demonstrated that hydroxysafflor yellow A (HSYA) could accelerate diabetic wound healing through promoting angiogenesis and reducing inflammatory response...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/30336792/angiogenic-t-cells-in-primary-sj%C3%A3-gren-s-syndrome-a-double-edged-sword
#7
Alessia Alunno, Lidia Ibba-Manneschi, Onelia Bistoni, Sabrina Cipriani, Fabiana Topini, Roberto Gerli, Mirko Manetti
OBJECTIVES: The mechanisms underlying increased cardiovascular risk in primary Sjögren's syndrome (pSS) remain unclear. Since the recently discovered angiogenic T cells (Tang) may participate in endothelial repair by cooperating with endothelial progenitor cells (EPC), we aimed at quantifying and characterising Tang in the peripheral blood and minor salivary glands (MSG) of pSS patients. METHODS: Tang (CD3+CD31+CXCR4+) and EPC (CD34+CD133+VEGFR-2+) were quantified by flow cytometry in peripheral blood samples from 36 pSS patients and 20 healthy donors...
October 15, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/30336141/hypertension-augmented-activity-of-matrix-metalloproteinases-2-and-9-and-angiogenic-imbalance-in-hypertensive-pregnancy-are-attenuated-by-doxycycline
#8
Regina A Nascimento, José S Possomato-Vieira, Victor H Gonçalves-Rizzi, Gisele F Bonacio, Elen Rizzi, Carlos A Dias-Junior
Preeclampsia is manifested as maternal hypertension and fetal growth restriction. Matrix metalloproteinases (MMPs) are involved in hypertension and doxycycline reduces blood pressure by inhibition of MMPs. Moreover, excessive levels of MMPs and reduced nitric oxide (NO) bioavailability have been related to preeclampsia. We investigated the involvement of MMPs in hypertension in pregnancy induced by Nω-Nitro-L-arginine methyl ester (L-NAME) in rats. To this end, zimography was performed to evaluate the activity of MMPs -2 and -9 in placenta, uterus and thoracic aorta, and systolic blood pressure, feto-placental development and metabolites of NO were evaluated...
October 15, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/30336134/pro-angiogenic-peptides-in-biomedicine
#9
REVIEW
Lucia De Rosa, Rossella Di Stasi, Luca Domenico D'Andrea
Pro-angiogenic therapy provides a promising new perspective in tackling of many common and severe pathological conditions, such as central and peripheral vascular diseases. Pro-angiogenic therapy also finds interesting applications in the regenerative medicine for the treatment of chronic wounds and in tissue engineering. However, clinical studies on therapeutic angiogenesis, mainly performed by administrating growth factors, have not led to convincing results until now, mainly due to the unfavorable pharmacokinetic and to safety concerns...
October 15, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/30335942/tetrahedral-dna-nanostructure-promote-endothelia-cells-proliferation-migration-and-angiogenesis-via-notch-signaling-pathway
#10
Dan Zhao, Mengting Liu, Qian-Shun Li, Xiaolin Zhang, Changyue Xue, Yun-Feng Lin, Xiaoxiao Cai
The problem of tissue vascularization is one of the obstacles that currently restrict the application of tissue engineering products to the clinic. Achieving tissue vascularization and providing adequate nutrients for tissues is an urgent problem to build complex and effective tissue-engineered tissues and organs. Therefore, the aim of this study was to investigate the effect of tetrahedral DNA nanostructures (TDNs), a novel and biocompatible nanomaterial, on angiogenesis. The results showed that TDNs can enter into endothelia cells (ECs) and promote ECs proliferation, migration, tube formation and the expressions of angiogenic growth factors at the concentration of 250nmol L-1, which was accompanied by activation of the Notch signaling pathway...
October 18, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/30335754/adipose-derived-mesenchymal-stem-cells-formed-acinar-like-structure-when-stimulated-with-breast-epithelial-cells-in-three-dimensional-culture
#11
Jing Tong, Shan Mou, Lingyun Xiong, Zhenxing Wang, Rongrong Wang, Annika Weigand, Quan Yuan, Raymund E Horch, Jiaming Sun, Jie Yang
Lipotransfer has been applied in breast augmentation surgery for several years and the resident adipose-derived stem cells (ASCs) play an important role in enhancing fat graft survival. However, the interaction between ASCs and mammary epithelium is not fully understood. Many studies have shown that ASCs have a tumor-supportive effect in breast cancer. To the best of our knowledge, this is the first study on the effect of mammary epithelial cells on the human ASCs in 3D culture. ASCs were cultivated on matrigel in the conditioned medium (CM) prepared from a human breast epithelial cell line (HBL-100)...
2018: PloS One
https://www.readbyqxmd.com/read/30334971/complete-metabolic-response-to-therapy-of-hepatic-epithelioid-hemangioendothelioma-evaluated-with-18f-fluorodeoxyglucose-positron-emission-tomography-contrast-enhanced-computed-tomography-a-care-case-report
#12
Romina Grazia Giancipoli, Serena Monti, Olca Basturk, David Klimstra, Mary Louise Keohan, Orazio Schillaci, Giuseppe Corrias, Peter Sawan, Lorenzo Mannelli
RATIONALE: Hepatic epithelioid hemangioendothelioma (EHE) is a rare malignant vascular tumor of endothelial origin with a highly variable clinical presentation and natural history. Given its vascular origin, new therapies with inhibitors of vascular endothelial growth factor (VEGF) have been introduced in the treatment of these patients and have shown promising results. Few reports have described the role of F-Fluorodeoxyglucose positron emission tomography/contrast-enhanced computed tomography (F-FDG PET/CT) in the evaluation of this tumor after treatment with anti-angiogenic agents...
October 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30333826/enzymatic-inactivation-of-oxysterols-in-breast-tumor-cells-constraints-metastasis-formation-by-reprogramming-the-metastatic-lung-microenvironment
#13
Marta A Moresco, Laura Raccosta, Gianfranca Corna, Daniela Maggioni, Matias Soncini, Silvio Bicciato, Claudio Doglioni, Vincenzo Russo
Recent evidence indicates that immune cells contribute to the formation of tumor metastases by regulating the pre-metastatic niche. Whether tumor-derived factors involved in primary tumor formation play a role in metastasis formation is poorly characterized. Oxysterols act as endogenous regulators of lipid metabolism through the interaction with the nuclear Liver X Receptors-(LXR)α and LXRβ. In the context of tumor development, they establish a pro-tumor environment by dampening antitumor immune responses, and by recruiting pro-angiogenic and immunosuppressive neutrophils...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30332982/the-impact-of-micrornas-in-breast-cancer-angiogenesis-and-progression
#14
Kontomanolis N Emmanuel, Fasoulakis Zacharias, Papamanolis Valentinos, Koliantzaki Sofia, Dimopoulos Georgios, Kambas J Nikolaos
OBJECTIVE To review the recent data considering the expression profile and the role of microRNAs in breast tumorigenesis, and their impact on -the vital for breast cancer progression- angiogenesis. METHODS PubMed was searched for studies focused on data that associate microRNA with breast cancer, using the terms ''breast", "mammary gland", "neoplasia'', "angiogenesis" and ''microRNA'' between 1997-2018. RESULTS Aberrant expression of several circulating and tissue miRNAs is observed in human breast neoplasms with the deregulation of several miRNAs having a major participation in breast cancer progression...
October 17, 2018: MicroRNA
https://www.readbyqxmd.com/read/30329172/pentraxin-3-level-is-elevated-in-hereditary-hemorrhagic-telangiectasia-and-reflects-the-severity-of-disease-associated-epistaxis
#15
Johan Steineger, Thor Ueland, Pål Aukrust, Anikka Michelsen, Terje Osnes, Ketil Heimdal, Sinan Dheyauldeen
OBJECTIVES/HYPOTHESIS: We aimed to investigate if vascular endothelial growth factor (VEGF) and other angiogenic and inflammatory factors correlated with the clinical presentation in hereditary hemorrhagic telangiectasia (HHT) patients, particularly in regard to the severity of epistaxis. STUDY DESIGN: Prospective, comparative, single-center study. METHODS: One hundred nine samples were collected from 75 HHT patients attending the ear, nose, and throat department at Oslo University Hospital from February 2012 to August 2013...
October 17, 2018: Laryngoscope
https://www.readbyqxmd.com/read/30328441/novel-devices-for-studying-acute-and-chronic-mechanical-stress-in-retinal-pigment-epithelial-cells
#16
Farhad Farjood, Elizabeth Vargis
Choroidal neovascularization (CNV) is a major cause of blindness in patients with age-related macular degeneration (AMD). Overexpression of vascular endothelial growth factor (VEGF), a potent angiogenic protein, by retinal pigment epithelial (RPE) cells is a key stimulator of CNV. Mechanical stress occurs during different stages of AMD and is a possible inducer of VEGF expression in RPE cells. However, robust and realistic approaches to studying acute and chronic mechanical stress under various AMD stages do not exist...
October 17, 2018: Lab on a Chip
https://www.readbyqxmd.com/read/30326915/the-effects-of-pigment-epithelium-derived-factor-on-atherosclerosis-putative-mechanisms-of-the-process
#17
REVIEW
Shouyuan Ma, Shuxia Wang, Man Li, Yan Zhang, Ping Zhu
Cardiovascular disease (CVD) is a leading cause of death worldwide. Atherosclerosis is believed to be the major cause of CVD, characterized by atherosclerotic lesion formation and plaque disruption. Although remarkable advances in understanding the mechanisms of atherosclerosis have been made, the application of these theories is still limited in the prevention and treatment of atherosclerosis. Therefore, novel and effective strategies to treat high-risk patients with atherosclerosis require further development...
October 17, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/30326377/ldl-apheresis-to-decrease-sflt-1-during-early-severe-preeclampsia-report-of-two-cases-from-a-discontinued-phase-ii-trial
#18
Bassam Haddad, Guillaume Lefèvre, Alexandra Rousseau, Thomas Robert, Samir Saheb, Cedric Rafat, Marie Bornes, Camille Petit-Hoang, Frédéric Richard, Edouard Lecarpentier, Vassilis Tsatsaris, Jean Guibourdenche, Anthony Corchia, Eric Rondeau, Tabassome Simon, Alexandre Hertig
OBJECTIVE: Severe preeclampsia may require the delivery of the placenta to avoid life-threatening complications for the mother. Before 26 weeks of gestation, this often results in perinatal death. A decrease in soluble fms-like tyrosine kinase 1 (sFlt1), an anti-angiogenic factor central to the pathophysiology of the maternal syndrome, has been reported after LDL- apheresis. The present study tested whether LDL-apheresis could be used to allow women with early and severe preeclampsia to reach a gestational age where the baby had a viable chance of survival...
September 11, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/30325017/anti-vascular-endothelial-growth-factor-for-diabetic-macular-oedema-a-network-meta-analysis
#19
REVIEW
Gianni Virgili, Mariacristina Parravano, Jennifer R Evans, Iris Gordon, Ersilia Lucenteforte
BACKGROUND: Diabetic macular oedema (DMO) is a common complication of diabetic retinopathy. Antiangiogenic therapy with anti-vascular endothelial growth factor (anti-VEGF) can reduce oedema, improve vision and prevent further visual loss. These drugs have replaced laser photocoagulation as the standard of care for people with DMO. OBJECTIVES: The 2014 update of this review found high-quality evidence of benefit with anti-VEGF modalities, compared to laser photocoagulation, for the treatment of DMO...
October 16, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/30324115/a-survey-on-the-role-of-interleukin-10-in-breast-cancer-a-narrative
#20
Elnaz Sheikhpour, Parisa Noorbakhsh, Elnaz Foroughi, Soudabeh Farahnak, Rezvan Nasiri, Hossein Neamatzadeh
Interleukin (IL)-10, a multifunctional immune-regulatory cytokine with both immunosuppressive and anti-angiogenic functions, is produced by immune cells including macrophages, T lymphocytes, and natural killer cells. Among other effects, IL-10 promotes tumor cell proliferation and metastasis via immunosuppression. Interleukin-10-mediated immunosuppression is aided by synthesis of tumor necrosis factor, IL-1, IL-12, and chemokines, and down regulation of the surface co-stimulatory molecules CD80 and CD86 on tumors...
October 2018: Reports of Biochemistry & Molecular Biology
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