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placental allografts

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https://www.readbyqxmd.com/read/30199609/evaluation-of-dehydrated-human-umbilical-cord-biological-properties-for-wound-care-and-soft-tissue-healing
#1
Jenn D Bullard, Jennifer Lei, Jeremy J Lim, Michelle Massee, Anna M Fallon, Thomas J Koob
Chronic wounds are a significant health care problem with serious implications for quality of life because they do not properly heal and often require therapeutic intervention. Amniotic membrane allografts have been successfully used as a biologic therapy to promote soft tissue healing; however, the umbilical cord, another placental-derived tissue, has also recently garnered interest because of its unique composition but similar placental tissue origin. The aim of this study was to characterize PURION® PLUS Processed dehydrated human umbilical cord (dHUC) and evaluate the biological properties of this tissue that contribute to healing...
September 10, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/30129890/biochemical-characterization-of-pure-dehydrated-binate-amniotic-membrane-role-of-cytokines-in-the-spotlight
#2
Mukta S Sane, Neha Misra, Nathan M Quintanar, Christopher D Jones, Soumyajit Banerjee Mustafi
AIM: Placental allografts used for tissue regeneration differ in membrane compositions and processing techniques. A uniquely folded dehydrated binate amniotic membrane (DBAM) was biochemically characterized to evaluate its potential role in wound healing. METHODS: Histology, Luminex-based immunoassay and standard in vitro cell biology techniques were employed. RESULTS: Histological staining confirmed that the DBAM was chorion free with epithelial cell layer of the respective amnion membranes facing outward...
September 2018: Regenerative Medicine
https://www.readbyqxmd.com/read/30008251/human-placental-membrane-as-a-wound-cover-for-chronic-diabetic-foot-ulcers-a-prospective-postmarket-closure-study
#3
Douglas J Pacaccio, Shawn M Cazzell, Gabriel J Halperin, Maria A Kasper, Joel M Neutel, Brian D O'Carroll, Alexander M Reyzelman
OBJECTIVE: To evaluate the safety and efficacy of a chorioamniotic allograft, used as a wound cover for chronic foot ulcers, in patients with diabetes. METHODS: A multicentre, prospective, postmarket study where eligible patients received up to 11 weekly wound cover applications. Computerised planimetry was used to calculate the diabetic foot ulcer (DFU) area each week. The primary endpoint of the study was wound closure assessment. Secondary endpoints included DFU recurrence and morbidity...
July 1, 2018: Journal of Wound Care
https://www.readbyqxmd.com/read/29869436/understanding-immune-tolerance-of-cancer-re-purposing-insights-from-fetal-allografts-and-microbes
#4
REVIEW
Megan B Barnet, Prunella Blinman, Wendy Cooper, Michael J Boyer, Steven Kao, Christopher C Goodnow
Cancer cells seem to exploit mechanisms that evolve as part of physiological tolerance, which is a complementary and often beneficial form of defense. The study of physiological systems of tolerance can therefore provide insights into the development of a state of host tolerance of cancer, and how to break it. Analysis of these models has the potential to improve our understanding of existing immunological therapeutic targets, and help to identify future targets and rational therapeutic combinations. The treatment of cancer with immune checkpoint inhibitors aims to reverse the progression to tolerance of cancer, and achieve an immunogenic, rather than tolerogenic, homeostasis...
August 2018: BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology
https://www.readbyqxmd.com/read/29861014/the-role-of-placental-membrane-allografts-in-the-surgical-treatment-of-tendinopathies
#5
REVIEW
Joel Ang, Chih-Kang David Liou, Harry P Schneider
Placental membrane grafts have long been used in the realms of wound care and ophthalmology to assist in the healing cascade. Recently, surgeons have started to implant placental membrane grafts in a wide variety of foot and ankle surgeries to take advantage of their many touted benefits. The application of placental membrane grafts for cases of lower extremity tendinopathy is detailed in this article.
July 2018: Clinics in Podiatric Medicine and Surgery
https://www.readbyqxmd.com/read/29703554/the-biological-basis-and-prevention-of-preterm-birth
#6
REVIEW
Gian Carlo Di Renzo, Valentina Tosto, Irene Giardina
The time of birth is a critical determinant of perinatal and long-term outcomes. Preterm birth is still the first cause of infant mortality and morbidity; unfortunately, rates of preterm birth remain high in both high- and low-resource countries, ranging from 5% to 18%. Preterm parturition is a syndrome, which can be induced by various factors such as infection, cervical pathology, uterine overdistension, progesterone deficiency, vascular alterations (utero-placental ischemia, decidual hemorrhage), maternal and fetal stress, allograft reaction, allergic phenomena, and probably other several unknown factors...
February 16, 2018: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29644033/a-case-of-dupuytren-s-disease-managed-with-viable-cryopreserved-placental-membrane-adjunct-to-open-palmar-fasciectomy
#7
Christopher M Dress, Elisabet K Tassis
Dupuytren's disease (DD) is a rare connective tissue disorder resulting in progressive fibrosis and thickening of the palmar fascia, and contracture of the fingers due to excessive collagen deposition. Staged surgical interventions are reserved for severe cases, yet worsening of fibrosis and contracture of fingers post-surgery, has been reported to have a recurrence rate as high as 85%. Here, the authors report on use of viable cryopreserved placental membrane (vCPM) allograft as an adjunct to open fasciectomy...
March 2018: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29607631/treatment-of-gingival-recession-using-a-coronally-advanced-flap-procedure-with-or-without-placental-membrane
#8
Sarah Grace George, Anil Kumar Kanakamedala, Jaideep Mahendra, Nashra Kareem, Little Mahendra, Jeethu John Jerry
AIM: The aim of the present study was to compare the treatment of gingival recession defects using a coronally-advanced flap procedure with or without placental membrane. METHODS: Sixty teeth in 15 patients with single and multiple Miller's class I and II gingival recession defects bilaterally in the anterior and premolar region of the maxilla and mandible were divided into two groups. In group I (control), 30 recession defects were treated with coronally-advanced flap alone using Zucchelli's technique...
August 2018: Journal of Investigative and Clinical Dentistry
https://www.readbyqxmd.com/read/29507646/epigenetic-regulation-of-placental-gene-expression-in-transcriptional-subtypes-of-preeclampsia
#9
Katherine Leavey, Samantha L Wilson, Shannon A Bainbridge, Wendy P Robinson, Brian J Cox
Background: Preeclampsia (PE) is a heterogeneous, hypertensive disorder of pregnancy, with no robust biomarkers or effective treatments. We hypothesized that this heterogeneity is due to the existence of multiple subtypes of PE and, in support of this hypothesis, we recently identified five clusters of placentas within a large gene expression microarray dataset ( N  = 330), of which four (clusters 1, 2, 3, and 5) contained a substantial number of PE samples. However, while transcriptional analysis of placentas can subtype patients, we propose that the addition of epigenetic information could discern gene regulatory mechanisms behind the distinct PE pathologies, as well as identify clinically useful potential biomarkers...
2018: Clinical Epigenetics
https://www.readbyqxmd.com/read/29306095/effect-of-polybrominated-diphenyl-ether-congeners-on-placental-cytokine-production
#10
Yuko Arita, Corinne Yeh, Theodosia Thoma, Darios Getahun, Ramkumar Menon, Morgan R Peltier
Polybrominated diphenyl ethers (PBDEs) are pollutants that may increase the risk of preterm birth. In previous studies, we found that a mixture of PBDEs altered the expression of biomarkers for preterm birth by the placenta. However, there are 209 different PBDE congeners with different tissue distributions. How these different congeners may alter the production of immunomodulators by the placenta that help to maintain the survival of the fetal allograft is unclear. Therefore, we compared the effects 5 common congeners on basal and bacteria-stimulated cytokine production by the placenta...
February 2018: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29275037/open-surgical-implantation-of-a-viable-intact-cryopreserved-human-placental-membrane-for-the-treatment-of-recalcitrant-plantar-fasciitis-case-report-with-greater-than-2-year-follow-up-duration
#11
REVIEW
Xingbo P Sun, Amy G Wilson, Georgina M Michael
Plantar fasciitis is one of the most common conditions encountered by a podiatric physician. Although most individuals respond well to traditional conservative and surgical remedies, a portion of patients will exhaust all available treatment options and will experience ongoing pain that can ultimately affect their quality of life. There has been an increase in scientific and clinical research surrounding the medical use of human placental membranes (HPMs) and many of these point-of-care allografts are now commercially available...
May 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29245303/viable-placental-allograft-as-a-biological-dressing-in-the-clinical-management-of-full-thickness-thermal-occupational-burns-two-case-reports
#12
Eric L Johnson, Elisabet K Tassis, Georgina M Michael, Susan G Whittinghill
RATIONALE: Occupational burn injuries can be detrimental and difficult to manage. The majority of complex cases are referred and managed at regional burn centers where access to specialized care is available. As an alternative to hospitalization with staged surgical procedures, placental products may be used for outpatient medical management of these common burn injuries, especially if access to a regional burn center is limited or restricted.Fresh amnion has been a treatment of choice in burns for more than 100 years...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28873060/a-retrospective-crossover-study-of-the-use-of-aseptically-processed-placental-membrane-in-the-treatment-of-chronic-diabetic-foot-ulcers
#13
Lawrence A DiDomenico, Dennis P Orgill, Robert D Galiano, Thomas E Serena, Marissa J Carter, Jarrod P Kaufman, Nathan J Young, Charles M Zelen
BACKGROUND: In a recently published, prospective randomized controlled trial (RCT) comparing aseptically processed dehydrated human amnion/chorion allograft (dHACA) to standard of care (SOC), 85% wound closure rates were reported in the dHACA arm while only 25% of patients in the SOC arm healed. OBJECTIVE: The purpose of this retrospective crossover study is to evaluate the effectiveness of dHACA in those patients that failed to respond to the SOC treatments and who exited the original study after failing up to 12 weeks of SOC treatment...
July 26, 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28872478/response-to-the-letter-to-the-editor-understanding-the-impact-of-preservation-methods-on-the-integrity-and-functionality-of-placental-allografts
#14
COMMENT
Amy Johnson, Alexandra Gyurdieva, Sandeep Dhall, Yi Duan-Arnold, Alla Danilkovitch
No abstract text is available yet for this article.
November 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28829757/chronic-inflammatory-lesions-of-the-placenta-are-associated-with-an-up-regulation-of-amniotic-fluid-cxcr3-a-marker-of-allograft-rejection
#15
Eli Maymon, Roberto Romero, Gaurav Bhatti, Piya Chaemsaithong, Nardhy Gomez-Lopez, Bogdan Panaitescu, Noppadol Chaiyasit, Percy Pacora, Zhong Dong, Sonia S Hassan, Offer Erez
OBJECTIVE: The objective of this study is to determine whether the amniotic fluid (AF) concentration of soluble CXCR3 and its ligands CXCL9 and CXCL10 changes in patients whose placentas show evidence of chronic chorioamnionitis or other placental lesions consistent with maternal anti-fetal rejection. METHODS: This retrospective case-control study included 425 women with (1) preterm delivery (n=92); (2) term in labor (n=68); and (3) term not in labor (n=265). Amniotic fluid CXCR3, CXCL9 and CXCL10 concentrations were determined by ELISA...
February 23, 2018: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28709842/what-compatibility-in-2017-for-the-haematopoietic-stem-cell-transplantation
#16
REVIEW
X Lafarge
The diversification of potential donors to perform stem cell allografts now enables to propose a compatible graft cell source adapted to the different clinical situations. Transplants with a geno-identical sibling donor, otherwise with the most HLA-compatible unrelated donor, remain the first-line solutions. Alternative transplants allow to graft patients having no donors in international registries, owing to the rarity of their HLA typing. They are carried out with fairly incompatible grafts and are therefore limited by the existence in the recipient of preformed anti-HLA antibodies which predispose to their rejection...
September 2017: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/28691395/low-expression-of-soluble-human-leukocyte-antigen-g-in-early-gestation-and-subsequent-placenta-mediated-complications-of-pregnancy
#17
Luca Marozio, Anna Garofalo, Paola Berchialla, Anna Maria Tavella, Loredana Salton, Franco Cavallo, Chiara Benedetto
AIM: Abnormal placentation is a common pathogenic mechanism of many placenta-mediated complications of late pregnancy, including pre-eclampsia, fetal growth restriction, stillbirth, and placental abruption. During successful placentation, the trophoblast (which is a semi-allograft) is not rejected by decidual immune cells because of maternal immune tolerance, mainly induced by human leukocyte antigen G (HLA-G). Deficient HLA-G expression seems to be associated with the development of complications of pregnancy...
September 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28585704/the-regulations-and-role-of-circadian-clock-and-melatonin-in-uterine-receptivity-and-pregnancy-an-immunological-perspective
#18
REVIEW
Gene Chi Wai Man, Tao Zhang, Xiaoyan Chen, Jianzhang Wang, Fangrong Wu, Yingyu Liu, Chi Chiu Wang, Ying Cheong, Tin Chiu Li
During normal pregnancy, the mechanism by which the fetus escapes immunological rejection by the maternal womb remains elusive. Given the biological complexities, the immunological mechanism is unlikely to be simply an allograft response in acceptance or rejection of the early pregnancy. Circadian clock responsible for the mammalian circadian rhythm is an endogenously generated rhythm associated with almost all physiological processes including reproduction. There is now growing evidence to suggest that the circadian clocks are intricately linked to the immune system and pregnancy...
August 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28542608/increase-in-complement-ic3b-is-associated-with-anti-inflammatory-cytokine-expression-during-late-pregnancy-in-mice
#19
Keigo Nakamura, Kazuya Kusama, Rulan Bai, Sadamasa Ishikawa, Sayuri Fukushima, Yoshihito Suda, Kazuhiko Imakawa
Immunological tolerance between fetal allograft and mother is crucial for pregnancy establishment and maintenance; however, these mechanisms particularly those during the latter part of pregnancy have not been definitively elucidated. The aim of this study was to examine the presence and potential function of innate immunity characteristic to the middle to late pregnancy. We first characterized up-regulated proteins in decidua from day 11 pregnant (P11) mice using 2D-PAGE, followed by MALDI-TOF/MS analysis...
2017: PloS One
https://www.readbyqxmd.com/read/28520231/lymphocyte-alloantigenic-challenge-as-a-potential-cofactor-in-hiv-infection-and-progression-to-aids
#20
Charles Hoff, Raymond D A Peterson
A hypothesis is developed that circulatory exposure to alloantigens found on lymphocytes triggers a series of events leading to suppression of the cell-mediated arm of the immune system and, therefore, that such alloantigenic challenge can be an important cofactor promoting infection with the human immunodeficiency virus (HIV) and development of the acquired immunodeficiency syndrome (AIDS) following infection. The explanatory model that is developed is based in large part on current knowledge of the results of fetal lymphocyte alloantigenic challenge of the maternal immune system...
1990: American Journal of Human Biology: the Official Journal of the Human Biology Council
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