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https://www.readbyqxmd.com/read/30315925/characterization-and-expression-of-androgen-receptors-in-olive-flounder
#1
Yuxia Zou, Limin Peng, Shenda Weng, Dongdong Liang, Zhaofei Fan, Zhihao Wu, Xungang Tan, Shuang Jiao, Feng You
Androgens are critical hormones that regulate sex differentiation, sexual maturation, and spermatogenesis in vertebrates, which is mainly mediated by androgen receptors (ARs). Reports on transcript variants of ar (AR encoding gene) in human are almost always associated with cancers and androgen insensitivity syndrome. However, the knowledge of ar variants in teleosts is scarce. In this study, arβ and two transcript variants of arα (arα1 and arα2) in olive flounder (Paralichthys olivaceus) were cloned and analyzed...
October 10, 2018: Gene
https://www.readbyqxmd.com/read/30315888/career-expectations-and-preferences-of-urology-residency-applicants
#2
Julia Han, Andrew Rabley, Alex Vlasak, Shahab Bozorgmehri, Vincent Bird, Louis Moy
OBJECTIVE: To survey the characteristics, career goals, and practice preferences of current urology applicants. METHODS: An anonymous survey was emailed to applicants pursuing a residency position at the University of Florida for the 2017-2018 academic year Urology Match. The survey included questions on demographics, motivating factors to pursue urology, plans for fellowship training, and anticipated and desired practice patterns. RESULTS: 151 of 295 applicants completed the survey, mean age 26...
October 10, 2018: Urology
https://www.readbyqxmd.com/read/30314831/patient-knowledge-and-attitudes-toward-cervical-cancer-screening-after-the-2012-screening-guidelines
#3
Jayanti M Clay, Joanne K Daggy, Sunetris Fluellen, Brownsyne Tucker Edmonds
OBJECTIVE: To assess women's attitudes and preferences related to recent changes in cervical cancer screening guidelines. METHODS: We distributed 380 surveys in three University based and Community clinics. Study participants anonymously completed surveys, which included questions related to demographics, cervical cancer, screening practices, risk perception and attitudes towards changing practices. RESULTS: 315 women agreed to participate (83%)...
October 3, 2018: Patient Education and Counseling
https://www.readbyqxmd.com/read/30314828/patient-clinician-communication-about-sexual-health-in-breast-cancer-a-mixed-methods-analysis-of-clinic-dialogue
#4
Jennifer Barsky Reese, Kristen Sorice, Stephen J Lepore, Mary B Daly, James A Tulsky, Mary Catherine Beach
OBJECTIVES: Breast cancer patients' sexual health needs are frequently unmet. We examined the prevalence and content of communication about sexual health between breast cancer patients and clinicians. METHODS: Female breast cancer patients being seen in oncology clinic follow-up had a clinic visit audio recorded and self-reported sexual problems after the visit. Transcripts were coded for sexual health communication; data were analyzed descriptively or using Chi-square tests...
October 4, 2018: Patient Education and Counseling
https://www.readbyqxmd.com/read/30313122/awareness-of-polish-undergraduate-and-graduate-students-regarding-the-impact-of-viral-infections-and-high-risk-sexual-behaviors-on-the-occurrence-of-oral-cancer
#5
Bogumił Lewandowski, Ewelina Czenczek-Lewandowska, Paweł Pakla, Jan Frańczak, Tomasz Piskadło, Małgorzata Migut, Robert Brodowski
With every passing year, more and more studies and observations demonstrate growing incidence of oral cancer, a decrease in patients' age, and an increasing number of epidemiological factors. The aim of the study was to determine the level of awareness among undergraduate and graduate university students regarding the incidence of oral cancer linked with viral infections and high-risk sexual behavior, including oral sex. Self-administered questionnaire-based survey was carried out among 196 Polish students aged 19 to 25 years...
October 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30306581/psychosexual-health-in-gynecologic-cancer
#6
Rosalind Boa, Seija Grénman
More people are living with the long-term effects of cancer owing to improvements in cancer treatments and an aging population. Many people diagnosed with cancer report a negative impact on sexual identity, sexual functioning, and their sexual relationship. Gynecologic cancer survivors are often the most severely affected. These cancers involve cancers of the ovaries, uterus, cervix, vagina, and vulva. The impact of these cancers on sexual health results not only from the disease process itself, but may also be due to the necessary treatments required...
October 2018: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/30304311/evaluation-of-body-image-quality-of-life-tactile-sensitivity-and-pain-in-women-with-breast-cancer-submitted-to-surgical-intervention
#7
Juliana Nishimura Bueno, Cinira Assad Simão Haddad, Samantha Karlla Lopes De Almeida Rizzi, Patricia Santolia Giron, Gil Facina, Afonso Celso Pinto Nazário
OBJECTIVE: Breast cancer is one of the most common types of tumor in the world and the most common among women. There are several treatments for breast cancer; however, the condition often can be accompanied by severe complications in a woman's life. To evaluate and compare body image perception, quality of life, tenderness, and pain in women with breast cancer during preoperative and postoperative periods of 30, 60 and 90 days. MATERIALS AND METHODS: We conducted a prospective longitudinal study...
June 2018: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/30303929/evaluation-of-prepectoral-implant-placement-and-complete-coverage-with-tiloop%C3%A2-bra-mesh-for-breast-reconstruction-a-prospective-study-on-long-term-and-patient-reported-breast-q-outcomes
#8
D Casella, G Di Taranto, M Marcasciano, S Sordi, A Kothari, T Kovacs, F Lo Torto, E Cigna, C Calabrese, D Ribuffo
BACKGROUND: Breast reconstruction is rapidly evolving, owing to the changing face of cancer surgery and the growing acceptance of acellular dermal matrices (ADM) and synthetic meshes. Although some early reports showed encouraging results after prepectoral breast reconstruction, there is a paucity of data on long term outcomes. METHODS: Between January 2012 and March 2015, 179 patients undergoing mastectomy were enrolled at our institution. Patients underwent mastectomy and immediate prepectoral breast reconstruction with the definitive implant entirely wrapped in a titanium-coated polypropylene mesh (TiLoop®)...
October 9, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/30302850/male-partners-experiences-of-caregiving-for-women-with-cervical-cancer-a-qualitative-study
#9
Karianne Oldertrøen Solli, Marjolein de Boer, Kari Nyheim Solbraekke, Lisbeth Thoresen
AIMS AND OBJECTIVES: This study aims to develop knowledge on the experiences of male partners of women with cervical cancer during and after the illness. We explore men's experiences of becoming caregivers as well as how the illness trajectory affects or has affected the relationship. BACKGROUND: Receiving a cancer diagnosis has a significant impact on the lives of both the cancer patient and their family members. However, studies of male partners' experiences with cancer patients are scarce...
October 9, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/30302805/identification-of-potential-drugs-targeting-l-l-diaminopimelate-aminotransferase-of-chlamydia-trachomatis-an-integrative-pharmacoinformatics-approach
#10
Anupriya Sadhasivam, Umashankar Vetrivel
Chlamydia trachomatis (C.t) is a gram-negative obligate intracellular bacteria, which is a major causative of infectious blindness and sexually transmitted diseases. A surge in multidrug resistance among chlamydial species has posed a challenge to adopt alternative drug targeting strategies. Recently, in C.t, L,L-diaminopimelate aminotransferase (CtDAP-AT) is proven to be a potential drug target due its essential role in cell survival and host nonspecificity. Hence, in this study, a multilevel precision-based virtual screening of CtDAP-AT was performed to identify potential inhibitors, wherein, an integrative stringent scoring and filtration were performed by coupling, glide docking score, binding free energy, ADMET (absorption, distribution, metabolism, and excretion, toxicity) prediction, density functional theory (quantum mechanics), and molecular dynamics simulation (molecular mechanics)...
October 10, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30300053/suboptimal-use-of-effective-contraceptive-methods-in-young-mexican-women-with-breast-cancer
#11
Andrea Castro-Sanchez, Bertha Alejandra Martinez-Cannon, Alejandra Platas, Alejandro Mohar, Alan Fonseca, Yoatzin Vega, Adrian Fimbres-Morales, Cynthia Villarreal-Garza
PURPOSE: Contraceptive counseling and adherence in young women with breast cancer (BC) is a relevant issue because chemotherapy and hormonal treatment resulting in amenorrhea do not preclude unintended pregnancies. Currently, there is limited evidence from high-income countries; however, there are no studies regarding use of contraceptives in patients with BC in Mexico. This study aimed to determine the rate of contraceptive use in young Mexican women with BC during cancer treatment, characterize their contraceptive preferences, and assess contraceptive counseling by Mexican physicians...
October 2018: Journal of Global Oncology
https://www.readbyqxmd.com/read/30298960/healthcare-professionals-perspectives-on-the-prevalence-barriers-and-management-of-psychosocial-issues-in-cancer-care-a-mixed-methods-study
#12
Bojoura Schouten, Jochen Bergs, Patrick Vankrunkelsven, Johan Hellings
This cross-sectional mixed methods survey explores healthcare professionals' perspective on their management of cancer patients' psychosocial concerns, and barriers to integrate the psychosocial approach in their work. An invitation for participation was sent to 4,965 inpatient and outpatient working professionals, of which 583 responded (12% response rate), and 368 fully completed the survey. The majority of respondents does not use a systematic approach to discuss patients' psychosocial concerns, 37.5% use the general question "How are you?," and 65...
October 9, 2018: European Journal of Cancer Care
https://www.readbyqxmd.com/read/30298205/rouhier-s-colpocleisis-with-concomitant-vaginal-hysterectomy-an-instructive-video-for-female-pelvic-surgeons
#13
Florin Constantin, Nikolaus Veit-Rubin, Lauriane Ramyead, Jean Dubuisson
INTRODUCTION AND HYPOTHESIS: The treatment of pelvic organ prolapse (POP) in elderly women can be challenging. The vaginal operation known as colpocleisis, the total occlusion of the urogenital hiatus, with concomitant hysterectomy was described by Rouhier and represents a safe, time-saving, and reproducible procedure in the case of POP associated with uterine pathological conditions. It is suitable for elderly women who do not require preservation of coital function. The objective of this video is to provide anatomical illustrations and a precise description of the surgical steps...
October 8, 2018: International Urogynecology Journal
https://www.readbyqxmd.com/read/30295567/the-self-reported-perceptions-of-the-repercussions-of-the-disease-and-its-treatments-on-daily-life-for-young-women-with-breast-cancer-and-their-partners
#14
Anne Congard, Véronique Christophe, Christelle Duprez, Anne-Sophie Baudry, Pascal Antoine, Anne Lesur, Catherine Loustalot, Cecile Guillemet, Monelle Leclercq, Carine Segura, Damien Carlier, Claudia Lefeuvre-Plesse, Helene Simon, Jean-Sebastien Frenel, Laurence Vanlemmens
PURPOSE: This study aimed to compare the self-reported perceptions of the repercussions of the disease and its treatments and emotional distress in young women with breast cancer and their partners. DESIGN: Cross-sectional study using self-reported questionnaires. SAMPLE: 491 couples in which women were aged <45 years when diagnosed with non-metastatic breast cancer in four different groups of treatment: during chemotherapy with or without Trastuzumab; under Trastuzumab with or without hormone therapy; during hormone therapy; and during the follow-up period...
October 8, 2018: Journal of Psychosocial Oncology
https://www.readbyqxmd.com/read/30295077/does-anti-m%C3%A3-llerian-hormone-predict-change-in-menopausal-symptoms-following-risk-reducing-salpingo-oophorectomy-a-prospective-observational-study
#15
R F M Vermeulen, M van Beurden, K N Gaarenstroom, T Teunis, J M Kieffer, N K Aaronson, G G Kenter, C M Korse
OBJECTIVES: The aim of this study was to investigate whether serum anti-Müllerian hormone (AMH) predicts symptom burden after risk-reducing salpingo-oophorectomy (RRSO) in order to individualize counseling. METHODS: Patient-reported menopausal symptoms, sexual functioning, and psychological distress (depression and anxiety) were assessed 1 day before (T0) and 6 weeks (T1) and 7 months (T2) after RRSO. AMH was assessed before RRSO. Multivariable regression analysis was used to investigate the association between AMH and short-term and long-term change in symptom burden following RRSO...
October 8, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/30294662/human-papilloma-virus-vaccine-awareness-and-vaccination-history-in-patients-attending-sti-clinics-in-lagos-and-ibadan-nigeria
#16
A O Faneye, A A Adeiga, O B Awoderu, A S Fayemiwo
HPV is one of the most common causes of sexually transmitted disease in both men and women worldwide. It is transmitted through vaginal, anal, and oral sex. This study provided information on the Human Papilloma Virus (HPV) vaccine awareness and vaccination history in relation to the level of antibodies to (HPV) in the population at risk in Nigeria. Patients attending STI clinics at Lagos and Ibadan were recruited and informed consent was obtained from all the participants. Using semi structured questionnaire, vaccination history, demography and past experiences of the patients were obtained...
February 2018: Archives of basic and applied medicine
https://www.readbyqxmd.com/read/30293923/quality-of-life-in-long-term-testicular-cancer-survivors-with-compensated-leydig-cell-dysfunction
#17
Julie Wang Skøtt, Jakob Lauritsen, Michael Bay Kreiberg, Gedske Daugaard, Mikkel Bandak
BACKGROUND: Compensated Leydig cell (LC) dysfunction, defined by elevated serum levels of luteinizing hormone (LH) in combination with normal total testosterone levels, is common in testicular cancer (TC) survivors. The association between this condition and quality of life is unknown. We aimed to clarify if TC survivors with compensated LC dysfunction have impaired quality of life. PATIENTS AND METHODS: In total, 147 long-term TC survivors were included. On the basis of a single measurement of testosterone and LH, compensated LC dysfunction was defined by age-adjusted levels of LH above normal range combined with testosterone levels within the normal range...
September 8, 2018: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/30286263/body-mass-index-and-sexual-function-in-women-with-gynaecological-cancer
#18
Hannah Donkers, Anke Smits, Antonio Eleuteri, Ruud Bekkers, Leon Massuger, Khadra Galaal
OBJECTIVES: To investigate the association between Body Mass Index (BMI) and sexual functioning in gynaecologic cancer patients. To determine the association between socioeconomic deprivation and sexual functioning. METHODS: This is a prospective cohort study on women undergoing surgery for suspected or proven gynaecological cancer between September 2014 and February 2016 in the Royal Cornwall Hospital Trust. Patients were invited to participate by completing the Female Sexual Function Index (FSFI) at three time points: pre-operative, three months post-operative and one-year post-operative...
October 4, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/30285780/robotic-versus-laparoscopic-surgery-for-rectal-cancer-in-male-urogenital-function-preservation-a-meta-analysis
#19
REVIEW
Xiaoli Tang, Zheng Wang, Xiaoqing Wu, Meiyuan Yang, Daorong Wang
BACKGROUND: Urogenital dysfunction after rectal cancer surgery can largely affect patients' postoperative quality of life. Whether robotic surgery can be a better option when comparing with laparoscopic surgery is still not well-known. METHODS: Comprehensive search in PubMed, Embase, Cochrane Library, and Clinical Trials was conducted to identify relevant studies in March 2018. Studies comparing robotic surgery with laparoscopic surgery were included. Measurement of urogenital function was through the International Prostate Symptom Score and International Index of Erectile Function...
October 2, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/30284239/preoperative-radiotherapy-and-curative-surgery-for-the-management-of-localised-rectal-carcinoma
#20
REVIEW
Iosief Abraha, Cynthia Aristei, Isabella Palumbo, Marco Lupattelli, Stefano Trastulli, Roberto Cirocchi, Rita De Florio, Vincenzo Valentini
BACKGROUND: This is an update of the original review published in 2007.Carcinoma of the rectum is a common malignancy, especially in high income countries. Local recurrence may occur after surgery alone. Preoperative radiotherapy (PRT) has the potential to reduce the risk of local recurrence and improve outcomes in rectal cancer. OBJECTIVES: To determine the effect of preoperative radiotherapy for people with localised resectable rectal cancer compared to surgery alone...
October 3, 2018: Cochrane Database of Systematic Reviews
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