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Sexuality cancer

Ryan N Montalvo, Brittany R Counts, James A Carson
PURPOSE OF REVIEW: We highlight evidence for sexual dimorphism in preclinical and clinical studies investigating the cause and treatment of cancer cachexia. RECENT FINDINGS: Cancer cachexia is unintended bodyweight loss occurring with cancer, and skeletal muscle wasting is a critical predictor of negative outcomes in the cancer patient. Skeletal muscle exhibits sexual dimorphism in fiber type, function, and regeneration capacity. Sex differences have been implicated in skeletal muscle metabolism, mitochondrial function, immune response to injury, and myogenic stem cell regulation...
August 9, 2018: Current Opinion in Supportive and Palliative Care
Daniel J Lee, Daniel A Barocas, Zhiguo Zhao, Li-Ching Huang, Matthew J Resnick, Tatsuki Koyoma, Ralph Conwill, Dan McCollum, Matthew R Cooperberg, Michael Goodman, Sheldon Greenfield, Ann S Hamilton, Mia Hashibe, Sherrie H Kaplan, Lisa E Paddock, Antoinette M Stroup, Xiao-Cheng Wu, David F Penson, Karen E Hoffman
PURPOSE: To compare patient-reported disease-specific functional outcomes after external beam radiation therapy (EBRT) and EBRT combined with low-dose-rate brachytherapy prostate boost (EB-LDR) among men with localized prostate cancer. METHODS AND MATERIALS: The prospective, population-based Comparative Effectiveness Analysis of Surgery and Radiation study enrolled men with localized prostate cancer in 2011 to 2012. The 26-item Expanded Prostate Cancer Index Composite measured patient-reported disease-specific function at baseline and at 6, 12, and 36 months...
September 1, 2018: International Journal of Radiation Oncology, Biology, Physics
H C Melissant, F Jansen, L E R Schutte, B I Lissenberg-Witte, J Buter, C R Leemans, M A Sprangers, M R Vergeer, E T M Laan, I M Verdonck-de Leeuw
INTRODUCTION: The aim of this prospective study was to investigate the course of sexual interest and enjoyment in relation to sociodemographic and clinical factors, health-related quality of life (HRQOL), and symptoms of psychological distress in head and neck cancer (HNC) patients treated with primary (chemo)radiotherapy. METHODS: HNC patients (n = 354) completed patient-reported outcome measures (PROMs) on HRQOL (EORTC QLQ-C30 and QLQ-H&N35, including the sexuality subscale covering less sexual interest and enjoyment), and psychological distress (HADS) pretreatment, at 6-week follow-up and at 3-, 6-, 12-, 18-, and 24-month follow-up (i...
August 2018: Oral Oncology
Niresh Thapa, Muna Maharjan, Yan Xiong, Daqiong Jiang, Thi-Phuong Nguyen, Marcia A Petrini, Hongbing Cai
We aimed to assess the quality of life (QOL) of the patients with cervical cancer after initial treatment, the factors affecting QOL and their clinical relevance. A total of 256 patients with cervical cancer who visited Zhongnan Hospital of Wuhan University from January 2017 to December 2017 were enrolled in this study. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core-30 item (EORTC QLQ-C30) and cervical cancer module (EORTC QLQ-CX24) was used to assess the QOL of patients...
August 10, 2018: Scientific Reports
Stana Pačarić, Jozo Kristek, Jure Mirat, Goran Kondža, Tajana Turk, Nikolina Farčić, Želimir Orkić, Ana Nemčić
BACKGROUND: Measuring the quality of life (QoL) of women with breast cancer is an important aspect of measuring treatment success. In Croatia, no QoL studies have been carried out with a focus on patients after mastectomy. The aim of this study was to examine QoL 1 month and 1 year after mastectomy. METHODS: This cross-sectional single-center study of quality of life was conducted in 101 patients, 50 of whom had undergone a mastectomy 1 month prior, and 51 of whom had undergone a mastectomy 1 year prior...
August 10, 2018: BMC Public Health
John Brodersen, Volkert Siersma, Hanne Thorsen
BACKGROUND: Cervical cancer screening will inevitably lead to unintentional harmful effects e.g. detection of indolent pathological conditions defined as overdetection or overdiagnosis. Overdiagnosis often leads to overutilisation, overtreatment, labelling and thereby negative psychosocial consequences. There is a lack of adequate psychosocial measures when it comes to measurement of the harms of medical screening. However, the Consequences of Screening questionnaire (COS) has been found relevant and comprehensive with adequate psychometric properties in breast and lung cancer screening...
August 10, 2018: BMC Psychology
Cara Clure, Colleen Rivard
Herpes simplex virus (HSV) is a common sexually transmitted infection. Although primary HSV typically presents with ulcerations, atypical presentations are possible. Only one other case report of HSV manifesting as a cervical mass exists. A 35-year-old immunocompetent female with dysuria was found to have a cervical mass concerning for cancer. She had a history of abnormal pap smears and a loop electrosurgical excision procedure   (LEEP) with poor follow-up. The patient was taken to the operating room for biopsies and staging and was found to have new vulvar ulcers...
June 6, 2018: Curēus
Jessica M Stringer, Elyse O K Swindells, Nadeen Zerafa, Seng H Liew, Karla J Hutt
With increasing improvements in cancer survival rates, it is critical to reduce the significant long-term side effects that afflict patients following treatment. For women, consequences of chemotherapy-induced damage to the reproductive system include infertility and premature menopause, which adversely effects cognition, mood, cardiovascular, bone, and sexual health, and increases the risk of early mortality. These long-term effects impact patient's life quality and highlight a significant and on-going burden on the health system after treatment...
August 2, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
Joren R Ten Hove, Jonathan M K Bogaerts, Michiel T J Bak, Miangela M Laclé, Vincent Meij, Lauranne A A P Derikx, Frank Hoentjen, Nofel Mahmmod, Sebastiaan A van Tuyl, Bas Oldenburg
Background: Patients with refractory inflammatory bowel disease (IBD) might require a subtotal colectomy with construction of an ileostomy. Due to the risk of nerve damage and pelvic sepsis, the diverted rectum is often left in situ. Evidence on long-term complications of this rectal stump is limited, particularly in patients with Crohn's disease (CD). In addition to the risk of development of neoplasia, diversion proctitis is a frequently reported rectal stump associated complication...
August 1, 2018: Inflammatory Bowel Diseases
Rūta Žulpaitė, Žana Bumbulienė
Current treatment schemes of childhood cancer are usually effective enough to enable successful management of the disease. With the high rates of survival, another problem arises because patients often suffer much later from side effects of the toxic therapy. A common complication caused by cancer treatment is impairment of the female reproductive system including dysfunction of the hypothalamus and hypophysis, the killing of gonadal cells, and uterine injury. This may lead to altered pubertal timing, gonadotropin insufficiency or deficiency, acute ovarian failure, premature ovarian insufficiency, sexual dysfunction, and complicated pregnancy...
2018: Ginekologia Polska
Ruth Kb Mome, Alison B Wiyeh, Eugene J Kongnyuy, Charles Shey Wiysonge
INTRODUCTION: The HIV pandemic continues to evolve with young women being the most vulnerable group to acquire infection. The presence of sexually transmitted infections (STIs) further enhances HIV susceptibility and also leads to long-term complications such as infertility and cervical cancer. The female condom is a self-initiated method for STI and HIV prevention but there are controversies on its effects. We aim to assess the effectiveness, safety and acceptability of the use of female condoms for prevention of STI and HIV acquisition among women...
August 5, 2018: BMJ Open
Chi Nguyen, David R Lairson, Michael D Swartz, Xianglin L Du
STUDY OBJECTIVE: To examine the risks and compare the occurrences of major long-term side effects (sexual dysfunction, bone fractures, diabetes, cardiovascular morbidity, acute myocardial infarction, and dementia) in patients with prostate cancer who received androgen deprivation therapy (ADT) with those who did not. DESIGN: Propensity score-matched retrospective cohort study using Medicare claims data. DATA SOURCE: National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) Program-Medicare linked database...
August 6, 2018: Pharmacotherapy
Cheryl Phua, Rodney Baber
The improved detection and successful treatment of breast cancer, resulting in better survival rates, has led to an increasing number of women living with the effects of treatment modalities and their long-term consequences. Menopausal symptoms following breast cancer can occur at an earlier age, be more severe and significantly influence a woman's overall wellbeing, in particular, sexual function, quality of life and adherence to treatment. There is a dearth of good quality evidence on the safest and most effective treatment options available for these women, and this article aims to summarize the current available treatments...
August 3, 2018: Drugs & Aging
Qing Chen, Shunping Li, Min Wang, Liu Liu, Gang Chen
Objectives: Breast cancer is one of the major cancers in Chinese women. European Organization for Research and Treatment of Cancer Quality of Life Questionnaires (EORTC QLQ-C30 and QLQ-BR23) are now the most common and well developed instruments assessing the health-related quality of life (HRQOL) of breast cancer patients internationally, whereas there are relatively few Chinese studies. This study has two aims: to investigate the HRQOL and explore which dimensions of HRQOL play more important roles in breast cancer patients' overall quality of life in China and to explore the latent factor structure and the potential complementary relationship between these two EORTC questionnaires...
2018: BioMed Research International
Noriyo Kaneko
BACKGROUND: The prevalence of cervical cancer among women aged 20-30 years has been increasing. A better understanding of the factors correlated with cervical cancer screening is vital to better identify suitable candidates and develop effective interventions. However, few studies have examined factors correlated with cervical cancer screening using a quantitative research design. Thus, this study aimed to assess the prevalence of and factors correlated with cervical cancer screening among unmarried and sexually active Japanese women aged 20-29 years...
July 31, 2018: BMC Women's Health
I Manini, E Montomoli
Human papillomavirus is the most common sexually transmitted infection, and skin-to-skin genital contact is sufficient for virus transmission. Cervical cancer is the second-most common cancer in women living in less developed regions, with an estimated 445,000 new cases in 2012 and 230,000 deaths every year. Until now, more than 200 types of HPV have been identified, and about 15 types (HPV-16, -18, -31, -33, -35, -39, -45, -51, -52, -56, -58, -59, -66, -68, -82) have been shown to cause cervical cancer because they are able to transform infected cells into malignant tumor cells...
July 2018: Annali di Igiene: Medicina Preventiva e di Comunità
Azra Lukac, Nenad Sulovic, Sonja Smiljic, Aleksandra N Ilic, Orhan Saban
Introduction/ Goals: The aim of our study was to point out the importance of the risk factors associated with cervical cancer in an asymptomatic population. Methodology: The study included 860 patients in the period from January 2017 to January 2018, which covered more than 80% of the targeted population in this municipality over the one year study, according to the National Program for Cervical Cancer Prevention in Montenegro. Results: The incidence of PAP III results was statistically significantly higher in women between 40 and 45 years of age compared to other age groups (p< 0...
June 2018: Materia Socio-medica
Jeanette Fingren, Elisabet Lindholm, Charlotta Petersén, Anne-Marie Hallén, Eva Carlsson
Having ostomy surgery changes a person's life. To assess adjustment to life with an ostomy and quality of life (QOL) 1 year after ostomy surgery, a prospective, explorative study was conducted among patients of a stoma clinic at a university hospital in Sweden. All consecutive patients who had undergone nonemergent or emergency surgery involving formation of an ostomy and who received regular follow-up at the ward and at the outpatient clinic during the first year by an enterostomal therapist (ET) were prospectively included in the study; their demographic information (including age, gender, diagnosis/reason for an ostomy, nonemergent or emergency surgery, ostomy type, preoperative counselling/siting [Yes/No], self-sufficiency in stoma care, professional activity, and whether they lived with a spouse/partner) was recorded upon admission to the study...
June 2018: Ostomy/wound Management
Anna E R Faris, Drogo K Montague, Bradley C Gill
INTRODUCTION: Men undergoing prostatectomy can have unrealistic preoperative expectations regarding sexual function after surgery and may desire more education on recovery and symptom management. AIM: To present contemporary data on recovery of sexual function after prostatectomy and characterize how it is impacted by perioperative patient educational interventions. METHODS: A comprehensive review of the English-language literature available by PubMed search...
July 26, 2018: Sexual Medicine Reviews
Mohammad Ali Soleimani, Nasim Bahrami, Ameneh Yaghoobzadeh, Averil Parker, Yiong Huak Chan
PURPOSE: This study aims to examine the correlation between sexual function and sexual distress, and to determine the predictive factors of sexual function and sexual distress in women with gynecologic cancers. METHODS: In this cross-sectional study, 387 subjects were referred to Velayat Hospital in Qazvin, Iran, using convenience sampling method between June and August 2016. Data were collected using a demographic questionnaire, the Female Sexual Function Index (FSFI), and the Female Sexual Distress Scale-Revised (FSDS-R)...
August 2018: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
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