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aging marker

Aunaly Palmer, Lisa A Taitsman, May J Reed, Bala G Nair, Itay Bentov
Hip fractures result in significant morbidity and mortality in elders. Indicators of frailty are associated with poor outcomes. Commonly used frailty tools rely on motor skills that cannot be performed by this population. We determined the association between the Charlson Comorbidity Score (CCS), intraoperative hypotension (IOH), and a geriatric medicine consult index (GCI) with short-term mortality in hip fracture patients. A retrospective cohort study was conducted at a single institution over a 2-year period...
2018: Geriatric Orthopaedic Surgery & Rehabilitation
David Parada Domínguez, Karla B Peña Gonzalez
Angiosarcoma is a rare soft tissue neoplasm, which accounts for <1% of all soft tissue tumours. It has been previously reported that the incidence rate of angiosarcomas increases following radiotherapy. The present study reports two cases of intra-abdominal angiosarcoma associated with previous radiotherapy treatment. To the best of our knowledge, these associations have not been previously described in English literature. The patients aged 71 and 83 years were admitted to the center for abdominal pain and diarrhea...
December 2018: Molecular and Clinical Oncology
Guangjie Zhao, Wanling Wu, Xiaoqin Wang, Jingwen Gu
Acute megakaryocytic leukemia (AMKL) is a rare subtype of acute myeloid leukemia (AML), which is challenging to diagnose due to frequent myelofibrosis (MF) and a low percentage of blast cells. In the present study, clinical characteristics and experimental observations in 9 adult patients diagnosed with AMKL, who were recruited by the Sino-U.S. Shanghai Leukemia Co-operative Group, were analyzed in order to summarize the diagnostic experience and provide recommendations on diagnosing AMKL. All the patients were diagnosed according to the 2008 World Health Organization diagnostic criteria...
December 2018: Oncology Letters
Romina Burla, Mattia La Torre, Giorgia Zanetti, Alex Bastianelli, Chiara Merigliano, Simona Del Giudice, Alessandro Vercelli, Ferdinando Di Cunto, Marina Boido, Fiammetta Vernì, Isabella Saggio
Epilepsy is a complex clinical condition characterized by repeated spontaneous seizures. Seizures have been linked to multiple drivers including DNA damage accumulation. Investigation of epilepsy physiopathology in humans imposes ethical and practical limitations, for this reason model systems are mostly preferred. Among animal models, mouse mutants are particularly valuable since they allow conjoint behavioral, organismal, and genetic analyses. Along with this, since aging has been associated with higher frequency of seizures, prematurely aging mice, simulating human progeroid diseases, offer a further useful modeling element as they recapitulate aging over a short time-window...
2018: Frontiers in Genetics
Mehrnush Amiri Siavashani, Shahrzad Zadeh Modarres, Naghmeh Mirhosseini, Esmat Aghadavod, Saghar Salehpour, Zatollah Asemi
Purpose: This study was performed to determine the effects of chromium supplementation on the gene expression of insulin, lipid, and inflammatory markers in infertile women with polycystic ovary syndrome (PCOS) who were candidate for in vitro fertilization (IVF). Methods: Forty women, aged 18-40 years, who had been selected for IVF were recruited in this randomized double-blinded, placebo-controlled trial. They ( n = 20/group) were randomly assigned into intervention groups to take either 200 μg/day of chromium or placebo for 8 weeks...
2018: Frontiers in Endocrinology
Gorka Fernández-Eulate, Ainhoa Alberro, Maider Muñoz-Culla, Miren Zulaica, Mónica Zufiría, Myriam Barandiarán, Igone Etxeberria, José Javier Yanguas, Maria Mercedes Gallardo, Nora Soberón, Ana María Lacosta, Virginia Pérez-Grijalba, Jesús Canudas, Noelia Fandos, Pedro Pesini, Manuel Sarasa, Begoña Indakoetxea, Fermin Moreno, Itziar Vergara, David Otaegui, Maria Blasco, Adolfo López de Munain
Many factors may converge in healthy aging in the oldest old, but their association and predictive power on healthy or functionally impaired aging has yet to be demonstrated. By detecting healthy aging and in turn, poor aging, we could take action to prevent chronic diseases associated with age. We conducted a pilot study comparing results of a set of markers (peripheral blood mononuclear cell or PBMC telomere length, circulating Aβ peptides, anti-Aβ antibodies, and ApoE status) previously associated with poor aging or cognitive deterioration, and their combinations, in a cohort of "neurologically healthy" (both motor and cognitive) nonagenarians ( n = 20) and functionally impaired, institutionalized nonagenarians ( n = 38) recruited between 2014 and 2015...
2018: Frontiers in Aging Neuroscience
F Marra, C Petronio, P Ceruleo, G Di Stefano, F Florindo, M Gatta, M La Rosa, M F Rolfo, L Salari
We present a combined geomorphological and biochronological study aimed at providing age constraints to the deposits forming a wide paleo-surface in the coastal area of the Tyrrhenian Sea, south of Anzio promontory (central Italy). We review the faunal assemblage recovered in Campoverde, evidencing the occurrence of the modern fallow deer subspecies Dama dama dama, which in peninsular Italy is not present before MIS 5e, providing a post-quem terminus of 125 ka for the deposit hosting the fossil remains. The geomorphological reconstruction shows that Campoverde is located within the highest of three paleosurfaces progressively declining towards the present coast, at average elevations of 36, 26 and 15 m a...
December 13, 2018: Scientific Reports
Giacomo Rossitto, Rhian M Touyz, Mark C Petrie, Christian Delles
Hypertonic Na+ accumulation in peripheral tissues is a recently described phenomenon: it has been associated with ageing, hypertension, diabetes, chronic kidney disease and heart failure, but its clinical meaning has yet to be determined. This concept conflicts with the classic physiological paradigm of constant balance between salt intake and excretion, and its water-independent nature is still a matter of debate.We developed a theoretical model explaining changes in the chemical composition of tissues as a function of extracellular volume fraction and excess extracellular fluid, i...
December 21, 2018: Clinical Science (1979-)
Christina B Johns, Cheryl Lacadie, Betty Vohr, Laura R Ment, Dustin Scheinost
Survivors of preterm birth experience long-lasting behavioral problems characterized by increased risk of depression, anxiety, and impairments in social functioning. The amygdala is a key region for social functioning and alterations in amygdala structure and connectivity are thought to underlie social functioning deficits in many disorders, including preterm birth. However, functional connectivity of the amygdala and its association with social impairments is not well-studied in preterm participants (PTs)...
December 3, 2018: NeuroImage: Clinical
Robert J Pignolo
Exceptional longevity represents an extreme phenotype. Current centenarians are survivors of a cohort who display delayed onset of age-related diseases and/or resistance to otherwise lethal illnesses occurring earlier in life. Characteristics of aging are heterogeneous, even among long-lived individuals. Associations between specific clinical or genetic biomarkers exist, but there is unlikely to be a single biomarker predictive of long life. Careful observations in the oldest old offer some empirical strategies that favor increased health span and life span, with implications for compression of disability, identification and implementation of lifestyle behaviors that promote independence, identification and measurement of more reliable markers associated with longevity, better guidance for appropriate health screenings, and promotion of anticipatory health discussions in the setting of more accurate prognostication...
December 6, 2018: Mayo Clinic Proceedings
Paula Nascimento Brandão-Lima, Gabrielli Barbosa de Carvalho, Ramara Kadija Fonseca Santos, Beatriz da Cruz Santos, Natalia Lohayne Dias-Vasconcelos, Vivianne de Sousa Rocha, Kiriaque Barra Ferreira Barbosa, Liliane Viana Pires
The role of the concomitant intake of zinc, potassium, calcium, and magnesium in the glycemic control of individuals with type 2 diabetes mellitus (T2DM) has not been extensively discussed. We evaluated the relationship between the dietary intake of these micronutrients and glycemic markers in 95 individuals with T2DM (mean age 48.6 ± 8.4 years). Hierarchical grouping analysis was used to divide the individuals into two clusters according to their micronutrient intake, and differences between clusters were statistically assessed...
December 8, 2018: Nutrients
Sara Pereira, Peter T Katzmarzyk, Donald Hedeker, José Maia
The co-occurrence of health-related markers and their associations with individual, family, and environmental characteristics have not yet been widely explored in siblings. We aimed to identify multivariate profiles of health-related markers, analyze their associations with biological, sociodemographic, and built environment characteristics, and estimate sibling resemblance in these profiles. The sample includes 736 biological siblings aged 9⁻20 years. Body fat was measured with a portable bioelectrical impedance scale; biological maturation was assessed with the maturity offset; handgrip strength, standing long jump, one-mile run, and shuttle run were used to mark physical fitness...
December 10, 2018: International Journal of Environmental Research and Public Health
You Zhou, Mingcai Zhao, Zheyan Pu, Guoqiang Xu, Xiangkun Li
The average age of hyperuricemia patients has gradually decreased, but young patients with primary hyperuricemia often do not exhibit clinical symptoms and have not received sufficient attention. However, a lack of symptoms with primary hyperuricemia does not mean that high serum uric acid (UA) levels cannot lead to pathological effects, such as oxidative stress and inflammation, and the specific damage is still unclear. We aimed to determine the relationship between oxidative stress and inflammation to explore the possible role of pathological damage in asymptomatic young patients with primary hyperuricemia...
December 2018: Medicine (Baltimore)
R Akbari Moghaddam Kakhki, Z Lu, A Thanabalan, H Leung, M Mohammadigheisar, E Kiarie
There is limited information on the effects of enteric pathogen on bone quality in rapidly growing broiler chicks. We examined tibia and femur attributes (length, diameter, relative weight of ash content [AC] to the BW, ash concentration [AP]) and serum bone-turnover markers including receptor activator of nuclear factor kappa-B ligand (RANKL) for resorption, alkaline phosphatase (ALP) for mineralization, and selected serum metabolites in 14-day-old broilers challenged with Eimeria. A total of 160 (80 males and 80 females) 1-day-old Ross × Ross 708 chicks were used...
December 13, 2018: Poultry Science
Keren Agay-Shay, Yaron Michael, Xavier Basagaña, Èrica Martínez-Solanas, David Broday, Itamar M Lensky, Mary Rudolf, Lisa Rubin, Rafi Kent, Nadav Levy, Ziona Haklai, Itamar Grotto
Background: Natural environments may have beneficial impacts on pregnancy outcomes. However, longitudinal evidence is limited and the associations with variance in surrounding greenness is unknown. Our objective was to evaluate these associations among 73 221 live births in Tel Aviv, Israel. Methods: Longitudinal exposure to mean of greenness during pregnancy and trimesters were calculated using satellite-based Moderate Resolution Imaging Spectroradiometer (MODIS) Normalised Difference Vegetation Index (NDVI) data...
December 13, 2018: International Journal of Epidemiology
Alison I C Donaldson, Toby O Smith, Sarah Alder, Alexandra M Johnstone, Baukje De Roos, Lorna S Aucott, Adam L Gordon, Phyo K Myint
Context: Care home residents are at risk of malnutrition owing to reduced food intake, anabolic resistance in aging muscle, and a high prevalence of medical morbidity and functional dependency. There has been limited consensus regarding the effectiveness of a high-protein diet on quality of life or clinical outcomes in care home residents. Objective: The aim of this review was to evaluate the effectiveness of nonmeat, high-protein supplementation on health-related quality of life (HRQOL) and relevant clinical and nutritional outcomes in older people in a care home setting...
December 13, 2018: Nutrition Reviews
Trajen Head, Lisa Henn, Victor P Andreev, Edward E Herderick, Sapna K Deo, Sylvia Daunert, Pascal J Goldschmidt-Clermont
IMPORTANCE: Most individuals who die of sudden cardiac death (SCD) display very advanced lesions of atherosclerosis in their coronary arteries. Thus, we sought to identify and characterize a putative subpopulation of young individuals exhibiting accelerated coronary artery atherosclerosis. OBJECTIVE: Our analysis of the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study-which examined 2651 individuals, obtaining quantitative measurements of traditional risk factors for coronary heart disease (CHD)-aimed to identify individuals with advanced coronary artery lesions, and to determine whether risk factors could account for such rapid disease progression, or not...
November 13, 2018: American Heart Journal
Josine E Verhoeven, Brenda W J H Penninx, Yuri Milaneschi
OBJECTIVE: While there is robust evidence for a cross-sectional association between depression and shorter telomere length, suggestive of advanced biological aging, the nature of this association remains unclear. Here, we tested whether both traits share a common genetic liability with novel methods using genomics. METHODS: Data were from 2032 participants of the Netherlands Study of Depression and Anxiety (NESDA) with genome-wide genetic information and multiple waves of data on DSM-IV lifetime depression diagnosis, depression severity, neuroticism and telomere length...
November 22, 2018: Psychoneuroendocrinology
Eleni Orfanoudaki, Maria Gazouli, Kalliopi Foteinogiannopoulou, Eirini Theodoraki, Evangelia Legaki, Ioannis Romanos, Ioannis Mouzas, Ioannis E Koutroubakis
BACKGROUND: Infliximab trough levels (IFX-TLs) and antibodies to infliximab (ATIs) have been suggested as useful markers for the optimization of treatment in inflammatory bowel disease (IBD). We aimed to estimate the patterns over time of IFX-TLs and ATIs in IBD patients on maintenance treatment with IFX. METHODS: Two different measurements of IFX-TLs and ATIs were performed (ELISA; Eagle BioSciences) at a 10-month interval using serum samples of consecutive patients on maintenance treatment with IFX...
December 12, 2018: European Journal of Gastroenterology & Hepatology
Lenka Turoňová, Kristína Kubejová, Karolína Vorčáková, Peter Ďurdík, Tatiana Péčová, Klára Martinásková
BACKGROUND: To evaluate the presence of endothelial dysfunction in Slovak children with juvenile psoriatic arthritis in the absence of classic cardiovascular risk factors in order to assess its relationship to the disease activity and disability. METHODS: 25 juvenile psoriatic arthritis patients (JPSA) and 25 healthy controls aged 6-19 years were enrolled into this study. In all subjects vascular measurements over a period of three years (January 2013 - January 2016) were performed, in accordance with the guidelines for ultrasonographic evaluation of FMD% (flow-mediated endothelial dependent vasodilatation) of the brachial artery...
2018: Acta Medica (Hradec Králové)
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