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aging marker

E A Kogan, N V Zharkov, S I Askolskaya, Yu V Popov, M A Krot, T A Demura
OBJECTIVE: To investigate the growth mechanisms of large uterine leiomyoma (LULM) on the basis of a clinical morphology examination, by providing immunohistochemical (IHC) characteristics of the expression of growth factors (transforming growth factor-beta (TGFβ) and platelet-derived endothelial cell growth factor (PD-ECGF)) and markers of stemness (CD117/c-kit, Connexin 43, Nestin) and proliferation (Ki-67). SUBJECT AND METHODS: The investigators examined surgical specimens from 38 women diagnosed with simple uterine leiomyoma (ULM), who had been divided into two groups: 1) 21 patients with LULM (>6 cm in diameter) (a study group); 2) 17 patients with small ULM (<4 cm in diameter) (a comparison group)...
2018: Arkhiv Patologii
Maciej Horyniecki, Beata Łącka-Gaździk, Ewa Niewiadomska, Bogdan Mazur, Mirosław Śnit, Beata Łabuz-Roszak
Introduction Chronic kidney disease (CKD) is one of stroke risk factors and may be associated with impaired platelet reactivity. Objectives The aim of the study was to evaluate the platelet reactivity in patients with CKD using acetylsalicylic acid (ASA). Patients and methods 108 patients with CKD and 41 controls without CKD taking ASA were enrolled in the study. Platelet function was assessed by impedance aggregometry in the whole blood using a multi-channel platelet function analyzer (Multiplate®). Urine concentration of 11-dehydrotromboxane was measured by AspirinWorks®...
October 18, 2018: Polish Archives of Internal Medicine
Pooja Dewan, Anupriya Dixit, Sunil Gomber, Mrinalini Kotru, Basu D Banerjee, Vipin Tyagi, Rajeev K Malhotra
Bone marrow iron estimation remains the gold standard for diagnosing iron-deficiency anemia (IDA); serum ferritin, total iron-binding capacity, and transferrin saturation are routinely used as surrogate markers of IDA. However, these tests are marred by problems like poor specificity and sensitivity. Recently, hepcidin, a protein hormone synthesized in the liver and excreted in urine, has been shown to be related to iron status. We estimated the serum and urinary hepcidin levels in healthy children aged 6 to 60 months with (n=30) and without IDA (n=30)...
October 16, 2018: Journal of Pediatric Hematology/oncology
Guilherme Pinheiro Machado, Gustavo N Araujo, Christian K Carpes, Mateus C Lech, Stefani Mariani, Felipe H Valle, Luiz C C Bergoli, Rodrigo V Wainstein, Marco V Wainstein
BACKGROUND: Elevated neutrophil-to-lymphocyte ratio (NLR) is an indirect marker of inflammation, and is associated with adverse clinical outcomes in patients with ST-segment elevation myocardial infarction (STEMI). The aim of this study was to investigate the usefulness of NLR to predict procedural adverse events is patients who underwent primary percutaneous coronary intervention (PCI). PATIENTS AND METHODS: Consecutive patients with STEMI who underwent primary PCI were divided into low and high NLR, whereas high was defined as an NLR value above 75° percentile (≥9...
October 16, 2018: Coronary Artery Disease
Jeremy D Kidd, Curtis Dolezal, Walter O Bockting
PURPOSE: Transgender individuals smoke tobacco at disproportionately higher rates than the general U.S. population, and concurrent use of gender-affirming hormones (estrogen or testosterone) and tobacco confers greater cardiovascular (CV) risk. This study examines the relationship between tobacco use and legal document gender-marker change, and medical/surgical interventions for gender transition. METHODS: Data came from an Internet-based survey of U.S. trans-feminine (n = 631) and trans-masculine (n = 473) individuals...
October 2018: LGBT Health
Tohru Michitsuji, Nozomi Iwanaga, Yoshiro Horai, Yoshika Tsuji, Chieko Kawahara, Yasumori Izumi, Ken Taniguchi, Shinichiro Yoshida, Atsushi Kawakami
AIM: To analyze the clinical course and prognosis in patients diagnosed with polymyalgia rheumatica (PMR) complicated by the presence of malignancies. METHODS: We retrospectively screened the case files of 216 patients hospitalized in our department between 2011 and December 2016 for the results of a thorough physical examination and data on treatment for rheumatic diseases. We identified 53 patients with PMR according to Bird's criteria and 43 patients with 2012 European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) classification criteria for PMR, then analyzed the clinical and serologic manifestations of PMR in patients with (n = 6) and without (n = 47 in Bird' criteria, n = 37 in 2012 EULAR/ACR criteria) malignancy...
October 18, 2018: Modern Rheumatology
Yoshinaga Okugawa, Yuji Toiyama, Akira Yamamoto, Tsunehiko Shigemori, Ayame Kitamura, Takashi Ichikawa, Shozo Ide, Takahito Kitajima, Hiroyuki Fujikawa, Hiromi Yasuda, Yoshiki Okita, Junichiro Hiro, Toshimitsu Araki, Donald C McMillan, Chikao Miki, Masato Kusunoki
BACKGROUND: The systemic inflammatory response (SIR) via host-tumor interactions has been termed the seventh hallmark of cancer, and several studies demonstrated that SIR might be a pivotal mediator for progression of cancer cachexia. The objective of this study was to clarify the correlation between sarcopenia and SIR in patients with colorectal cancer (CRC). METHODS: A total of 308 patients with CRC were enrolled in this study. Preoperative psoas muscle mass index and intramuscular adipose tissue content were evaluated using preoperative computed tomographic images, and the correlation between body composition status and several SIR markers, including C-reactive protein (CRP), serum albumin level, neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, and systemic immune-inflammation index (SII) was assessed using statistical methods...
October 18, 2018: JPEN. Journal of Parenteral and Enteral Nutrition
R Hartman, P Patil, R Tisherman, C St Croix, L J Niedernhofer, P D Robbins, F Ambrosio, B Van Houten, G Sowa, N Vo
Robust cellular bioenergetics is vital in the energy-demanding process of maintaining matrix homeostasis in the intervertebral disc. Age-related decline in disc cellular bioenergetics is hypothesised to contribute to the matrix homeostatic perturbation observed in intervertebral disc degeneration. The present study aimed to measure how ageing impacted disc cell mitochondria and bioenergetics. Age-related changes measured included matrix content and cellularity in disc tissue, as well as matrix synthesis, cell proliferation and senescence markers in cell cultures derived from annulus fibrosus (AF) and nucleus pulposus (NP) isolated from the discs of young (6-9 months) and older (36-50 months) New Zealand White rabbits...
October 18, 2018: European Cells & Materials
Daniel Beltrame Ferreira, Walter Henriques da Costa, Diego Abreu Clavijo, Ricardo Decia, Isabela Werneck Cunha, Luciana Schultz, Rafael Malagoli Rocha, Gustavo Cardoso Guimarães, Stênio de Cássio Zequi
Objective: To evaluate immunohistochemical erythropoietin (EPO) expression in clear cell renal cell carcinoma (ccRCC), its association with major clinicopathological variables and its prognostic impact. Methods: A total of 220 patients with renal cell carcinoma (RCC) surgically treated between 1989 and 2009 were evaluated in this multi-institutional study. All the cases were reviewed by a single pathologist and the immunohistochemical reactivity to EPO was analysed using tissue microarray...
November 27, 2017: Kidney cancer
Shraddha Sapkota, Tao Huan, Tran Tran, Jiamin Zheng, Richard Camicioli, Liang Li, Roger A Dixon
Background : Among the neurodegenerative diseases of aging, sporadic Alzheimer's disease (AD) is the most prevalent and perhaps the most feared. With virtually no success at finding pharmaceutical therapeutics for altering progressive AD after diagnosis, research attention is increasingly directed at discovering biological and other markers that detect AD risk in the long asymptomatic phase. Both early detection and precision preclinical intervention require systematic investigation of multiple modalities and combinations of AD-related biomarkers and risk factors...
2018: Frontiers in Aging Neuroscience
C N Guruprasad, A R Pradeep
Interleukin-34 (IL-34), an alternative ligand for macrophage colony-stimulating factor receptor, plays an important role in osteoclastogenesis. The aim of this study was to analyze the effect of smoking on IL-34 levels in gingival crevicular fluid (GCF) and plasma in individuals with healthy periodontium and chronic generalized periodontitis (CP). A total of 60 individuals ranging in age from 25 to 55 years were enrolled in the study. The participants were divided into 4 groups: Group A, 30 samples (15 GCF and 15 plasma) obtained from 15 non-smokers with healthy periodontium; Group B, 30 samples (15 GCF and 15 plasma) from 15 smokers with healthy periodontium; Group C, 30 samples (15 GCF and 15 plasma) from 15 non-smokers with CP; and Group D, 30 samples (15 GCF and 15 plasma) from 15 smokers with CP...
October 18, 2018: Bulletin of Tokyo Dental College
Vijitha Burra, P S Nagaraja, Naveen G Singh, V Prabhakar, N Manjunatha
Background: Acute kidney injury (AKI) is a strong predictor of morbidity and mortality after cardiac surgery. Lack of valid early biomarkers for predicting AKI has hampered the ability to take therapeutic measures for preventive cause. Hyperphosphatemia that occurs in AKI due to renal excretion defect was not studied in this context and could be simple marker of AKI. Therefore, we tested role of serum phosphorus in prediction of AKI as a biomarker after cardiac surgery in children. Methodology: We prospectively evaluated 51 children aged between 3 weeks and 12 years undergoing elective cardiac surgery...
October 2018: Annals of Cardiac Anaesthesia
Pustika Amalia Wahidiyat, Stephen Diah Iskandar, Damayanti Sekarsari
BACKGROUND: routine blood transfusion in transfusion-dependent-thalassemia (TDT) causes iron accumulation in various organ. Serum markers of iron overload, serum ferritin and transferrin saturation, are sensitive but not specific. MRI T2-star (T2*) is valuable for detecting iron level in organs. This study aimed to explore the degree of iron overload in various organs, iron deposition difference between children and adults, also its correlation with serum marker of iron overload. METHODS: this was a cross-sectional study of TDT patients who had been evaluated by MRI T2* examination in Cipto Mangunkusumo Hospital from 2014 to 2018...
July 2018: Acta Medica Indonesiana
Eva Piccand, Peter Vollenweider, Idris Guessous, Pedro Marques-Vidal
OBJECTIVE: To assess the associations between single foods, nutrients, dietary patterns and dietary scores, and inflammatory markers (C-reactive protein (CRP), IL-6, TNF-α and leucocyte count). DESIGN: Cross-sectional, population-based study. SETTING: City of Lausanne, Switzerland, years 2009-2012. SUBJECTS: Adults (n 4027; 46·5 % men), mean age 57·2 (sd 10·2) years. Dietary intake was collected using a semi-quantitative FFQ...
October 18, 2018: Public Health Nutrition
Haris Zahoor, Pedro C Barata, Xuefei Jia, Allison Martin, Kimberly D Allman, Laura S Wood, Timothy D Gilligan, Petros Grivas, Moshe C Ornstein, Jorge A Garcia, Brian I Rini
BACKGROUND: Nivolumab is approved for the treatment of refractory metastatic renal cell carcinoma. Patterns and predictors of progressive disease (PD) on nivolumab, and outcomes in such patients are lacking. METHODS: A retrospective analysis of patients (pts) with metastatic clear cell renal cell carcinoma (ccRCC) who received nivolumab at Cleveland Clinic (2015-2017) was performed. PD was defined per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 or clinical progression as per treating physician...
October 17, 2018: Journal for Immunotherapy of Cancer
Sadegh Jafarnejad, Virginia Boccardi, Banafshe Hosseni, Mohsen Taghizadeh, Zahra Hamedifard
OBJECTIVE: The present meta-analysis was designed to assess the effects of vitamin C supplementation on serum C-reactive protein (CRP) levels. METHODS: We conducted a comprehensive systematic search of literature in Scopus, PubMed and Google Scholar until May 2018. The pooled weighted mean difference (WMD) and its 95% confidence interval (CI) in baseline and at the end of trial were calculated to assess the net change in serum CRP by using random-effects model. The heterogeneity was assessed by I2 test...
October 16, 2018: Current Pharmaceutical Design
Mahvash Shere, Tye E Arbuckle, Patricia Monnier, William Fraser, Maria P Velez
OBJECTIVES: Time-to-Pregnancy (TTP) is an epidemiological tool to assess couple fecundity. The finger digit ratio (2D:4D) has been suggested as a marker of androgen exposure in utero. Maternal, paternal, or couple-mediated factors related to fecundity may also have an effect on androgen exposure during pregnancy. We aimed to investigate the association between TTP, infertility, or use of Assisted Reproductive Technologies (ART) and offspring 2D:4D. METHODS: Data from 673 mother-child pairs were collected from questionnaires in the Maternal-Infant Research on Environmental Chemicals (MIREC) study across 10 cities in Canada...
October 17, 2018: American Journal of Human Biology: the Official Journal of the Human Biology Council
Anthony Noor, Catherine Gibb, Sam Boase, John-Charles Hodge, Suren Krishnan, Andrew Foreman
OBJECTIVE: To provide a summary of the current frailty literature relating to head and neck cancer. DATA SOURCES: Ovid MEDLINE, PubMed, Google Scholar. METHODS: A comprehensive review of the literature was performed from 2000 to 2017 using key words frailty, elderly, geriatric, surgery, otolaryngology, head and neck cancer. RESULTS: The aging population has led to an increased diagnosis of head and neck cancer in elderly patients...
October 17, 2018: Laryngoscope
Mehmet A Bilen, Dylan J Martini, Yuan Liu, Colleen Lewis, Hannah H Collins, Julie M Shabto, Mehmet Akce, Haydn T Kissick, Bradley C Carthon, Walid L Shaib, Olatunji B Alese, Rathi N Pillai, Conor E Steuer, Christina S Wu, David H Lawson, Ragini R Kudchadkar, Bassel F El-Rayes, Viraj A Master, Suresh S Ramalingam, Taofeek K Owonikoko, R Donald Harvey
BACKGROUND: Optimal prognostic and predictive biomarkers for patients with advanced-stage cancer patients who received immunotherapy (IO) are lacking. Inflammatory markers, such as the neutrophil-to-lymphocyte ratio (NLR), the monocyte-to-lymphocyte ratio (MLR), and the platelet-to-lymphocyte ratio (PLR), are readily available. The authors investigated the association between these markers and clinical outcomes of patients with advanced-stage cancer who received IO. METHODS: A retrospective review was conducted of 90 patients with advanced cancer who received treatment on phase 1 clinical trials of IO-based treatment regimens...
October 17, 2018: Cancer
Takashi Ono, Tomomi Kouguchi, Akira Ishikawa, Atsushi J Nagano, Atsushi Takenouchi, Takeshi Igawa, Masaoki Tsudzuki
The shear force value is one of the major traits that determine meat quality. In the present study, we performed QTL analysis for chicken breast muscle shear force value at 7 wk of age using 545 single nucleotide polymorphism (SNP) markers developed via restriction-site associated DNA sequencing (RAD-seq). An F2 resource family was generated by mating Oh-Shamo, a native Japanese chicken breed, and the White Plymouth Rock chicken breed. A total of 215 F2 birds were produced. Simple interval mapping revealed one significant main-effect QTL between 6...
October 17, 2018: Poultry Science
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