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aging marker

Leena Antikainen, Jarmo Jääskeläinen, Henrikki Nordman, Raimo Voutilainen, Hanna Huopio
BACKGROUND: Maternal gestational diabetes mellitus (GDM) and overweight are associated with an increased risk of obesity and the metabolic syndrome in the adult offspring. We studied the influence of maternal GDM on prepubertal children's height, weight, body mass index (BMI), lipid and glucose metabolism, and low-grade inflammation. METHODS: A cohort of 135 prepubertal Caucasian children (age range 4.4-9.7 years) was studied in a controlled cross-sectional study...
August 15, 2018: Hormone Research in Pædiatrics
Madhukar H Trivedi, Charles South, Manish K Jha, A John Rush, Jing Cao, Benji Kurian, Mary Phillips, Diego A Pizzagalli, Joseph M Trombello, Maria A Oquendo, Crystal Cooper, Daniel G Dillon, Christian Webb, Bruce D Grannemann, Gerard Bruder, Patrick J McGrath, Ramin Parsey, Myrna Weissman, Maurizio Fava
BACKGROUND: One in three clinical trial patients with major depressive disorder report symptomatic improvement with placebo. Strategies to mitigate the effect of placebo responses have focused on modifying study design with variable success. Identifying and excluding or controlling for individuals with a high likelihood of responding to placebo may improve clinical trial efficiency and avoid unnecessary medication trials. METHODS: Participants included those assigned to the placebo arm (n = 141) of the Establishing Moderators and Biosignatures for Antidepressant Response in Clinical Care (EMBARC) trial...
August 15, 2018: Psychotherapy and Psychosomatics
Emily S Riddle, Erica L Bender, Anna E Thalacker-Mercer
Activation of satellite cells and expansion of the muscle progenitor cell (MPC) population is essential to generate a sufficient number of cells to repair damaged skeletal muscle. Proliferating MPCs have high energetic and biosynthetic material requirements, and the ability to utilize oxidative phosphorylation (OXPHOS) and/or glycolysis may affect expansion capacity of MPCs. In the present study, we investigated whether donor age and sex impact human MPC (hMPCs) expansion capacity and metabolic fuel preference...
August 15, 2018: American Journal of Physiology. Cell Physiology
Bruna Emanuelle Sanches Borges, Elza Baia de Brito, Hellen Thais Fuzii, Cláudia Simone Baltazar, Aline Barreto Sá, Camile Irene Mota da Silva, Gleyce de Fátima Silva Santos, Maria da Conceição Nascimento Pinheiro
Objective To investigate the relation between oxidative stress markers, human papillomavirus infection and cervical cancer precursor lesions. Methods The study comprised women aged 14 to 60 years living in communities located by Amazon rivers in the state of Pará (Itaituba, Limoeiro do Ajuru and Bragança, 126, 68 and 43 women respectively). Papanicolau smears and polymerase chain reaction tests for human papillomavirus DNA detection were performed. Blood samples were collected to test malondialdehyde, total and oxidized glutathione levels...
2018: Einstein
Miriam S Hohmann, David M Habiel, Ana L Coelho, Waldiceu A Verri, Cory M Hogaboam
While cellular senescence may be a protective mechanism in modulating proliferative capacity, fibroblast senescence is now recognized as a key pathogenic mechanism in Idiopathic Pulmonary Fibrosis (IPF). In aged mice, abundance and persistence of apoptosis-resistant senescent fibroblasts play a central role in non-resolving lung fibrosis after bleomycin challenge. Therefore, we investigated whether quercetin can restore the susceptibility of senescent IPF fibroblasts to pro-apoptotic stimuli and mitigate bleomycin-induced pulmonary fibrosis in aged mice...
August 15, 2018: American Journal of Respiratory Cell and Molecular Biology
Elisabetta Mattioli, Davide Andrenacci, Cecilia Garofalo, Sabino Prencipe, Katia Scotlandi, Daniel Remondini, Davide Gentilini, Anna Maria Di Blasio, Sergio Valente, Emanuela Scarano, Lucia Cicchilitti, Giulia Piaggio, Antonello Mai, Giovanna Lattanzi
Defects in stress response are main determinants of cellular senescence and organism aging. In fibroblasts from patients affected by Hutchinson-Gilford progeria, a severe LMNA-linked syndrome associated with bone resorption, cardiovascular disorders, and premature aging, we found altered modulation of CDKN1A, encoding p21, upon oxidative stress induction, and accumulation of senescence markers during stress recovery. In this context, we unraveled a dynamic interaction of lamin A/C with HDAC2, an histone deacetylase that regulates CDKN1A expression...
August 15, 2018: Aging Cell
Chandan Vangala, Jenny Pan, Ronald T Cotton, Venkat Ramanathan
The risk of mineral and bone disorders among patients with chronic kidney disease is substantially elevated, owing largely to alterations in calcium, phosphorus, vitamin D, parathyroid hormone, and fibroblast growth factor 23. The interwoven relationship among these minerals and hormones results in maladaptive responses that are differentially affected by the process of kidney transplantation. Interpretation of conventional labs, imaging, and other fracture risk assessment tools are not standardized in the post-transplant setting...
2018: Frontiers in Medicine
Carlos Salazar, Nelson Kanter Md, Amer Abboud
Malignant pleural mesothelioma (MPM) is a rare neoplasm. It predominantly affects elderly individuals aged over 70 years presenting with a unilateral pleural tumor usually associated with previous asbestos exposure. The respiratory symptoms are associated with ipsilateral pleural involvement with concomitant pleural effusions. The diagnosis of MPM is established by the morphologic and immunohistochemical features of a cytologic specimen. MPM can present as three histologic subtypes: epithelioid, sarcomatoid, or biphasic...
June 6, 2018: Curēus
Nida Saleem, Tahir Aziz Ahmed, Mukarram Bashir, Muhammad Omair Riaz, Ali Hamid
OBJECTIVE: To compare the frequency and the functional state of the collagen II reactive T cells with disease activity in rheumatoid arthritis patients and healthy controls. METHODS: This case-control cross-sectional study was carried out at the Department of Immunology; Armed Forces Institute of Pathology, Rawalpindi, Pakistan, from June to October 2014. Rheumatologist from Rehmat Noor Rheumatology Clinic, a private health facility of the city, was requested to send in patients with clinical diagnosis of rheumatoid arthritis...
August 2018: JPMA. the Journal of the Pakistan Medical Association
Masahir Okamoto, Jason D Gray, Chloe S Larson, Syed Faraz Kazim, Hideaki Soya, Bruce S McEwen, Ana C Pereira
Alzheimer's disease (AD) represents a major healthcare burden with no effective treatment. The glutamate modulator, riluzole, was shown to reverse many AD-related gene expression changes and improve cognition in aged rats. However, riluzole's effect on amyloid beta (Aβ) pathology, a major histopathological hallmark of AD, remains unclear. 5XFAD transgenic mice, which harbor amyloid β precursor protein (APP) and presenilin mutations and exhibit early Aβ accumulation, were treated with riluzole from 1 to 6 months of age...
August 14, 2018: Translational Psychiatry
Ronen Eavri, Jason Shepherd, Christina A Welsh, Genevieve H Flanders, Mark Bear, Elly Nedivi
Changes in excitatory neuron and synapse structure have been recognized as a potential physical source of age-related cognitive decline. Despite the importance of inhibition to brain plasticity, little is known regarding aging associated changes to inhibitory neurons. Here we test for age-related cellular and circuit changes to inhibitory neurons of mouse visual cortex. We find no substantial difference in inhibitory neuron number, inhibitory neuronal subtypes, or synapse numbers within the cerebral cortex of aged mice as compared to younger adults...
August 14, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Jared H Hara, Ashley Wu, Javier E Villanueva-Meyer, Gilmer Valdes, Vikas Daggubati, Sabine Mueller, Timothy D Solberg, Steve E Braunstein, Olivier Morin, David R Raleigh
PURPOSE: To investigate the prognostic utility of quantitative 3-dimensional magnetic resonance imaging radiomic analysis for primary pediatric embryonal brain tumors. METHODS AND MATERIALS: Thirty-four pediatric patients with embryonal brain tumor with concurrent preoperative T1-weighted postcontrast (T1PG) and T2-weighted fluid-attenuated inversion recovery (FLAIR) magnetic resonance images were identified from an institutional database. The median follow-up period was 5...
June 8, 2018: International Journal of Radiation Oncology, Biology, Physics
Taku Hatano, Masashi Takanashi, Hitoshi Tsuchihashi, Shin-Ichi Ueno, Arisa Hayashida, Yutaka Tsukune, Kazuaki Kanai, Yasushi Shimo, Nobutaka Hattori
BACKGROUND: Cutaneous and systemic plasmacytosis are skin disorders characterized by cutaneous polyclonal plasma cell infiltration accompanied by polyclonal hypergammaglobulinemia. Cutaneous plasmacytosis involvement is limited to the skin, mainly on the face and trunk, while systemic plasmacytosis also involves 2 or more organ systems. However, there have been no reports of inflammatory myositis due to plasmacytosis. Here, we report a patient with plasmacytosis who developed myalgia and easy fatigability due to inflammatory myositis...
August 14, 2018: BMC Neurology
K R Lin, J Q Zhu, J Li, J C Gu, H C Li, R Wei, Y Guo, Y Y Wang, H Y Wang, D L Fu
Objective: To analyze the causes of preoperative miscarriage of pancreatic serous cystadenoma (SCN) and find the ways to improve it. Methods: Clinical data of 425 pancreatic cystic neoplasm patients who underwent surgical resection from January 2006 to December 2016 in Department of Pancreatic Surgery in Huashan Hospital were retrospectively analyzed.Excel database was created which covered 128 fields of 7 fields: general information of patients, preoperative blood biochemical indexes, tumor markers, surgical related data, postoperative complications, imaging findings and pathology...
August 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
M Zhao, A X Wang, X Zhu, J J Yu, W Wang, D H Zhang, X L He, H Y He, X D Teng
Objective: To investigate the clinicopathologic and differential diagnostic features of glomus tumor of the kidney. Methods: Four cases of glomus tumor of the kidney were collected from the archives of Peking University Third Hospital, the Second Hospital of Tianjin Medical University, Ningbo Yinzhou Second Hospital and Zhejiang Provincial People's Hospital between January 2012 to June 2017; the clinical and radiologic features, histomorphology, immunohistochemistry, ultrastucture and prognosis were analyzed and the relevant literature was reviewed...
August 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
Norma Angélica Estrada Cruz, Julio César Almanza Pérez, Ángeles Fortis Barrera, Juan Manuel Gallardo, Leticia Manuel Apolinar, Julia Jeanett Segura Uribe, Sandra Orozco Suárez, Angélica Coyoy Salgado, Christian Guerra Araiza
In addition to oxidative stress due to the increase of free radicals, estrogen deficiency is associated with changes in enzymatic activity, glutathione redox ratio (GSH/GSSG), and the content of oxidative markers such as malondialdehyde. Tibolone, a synthetic steroid, has been used as an elective treatment for the relief of menopausal symptoms. However, the acute effects of hormonal therapy with tibolone on metabolic parameters and oxidative stress markers associated with the first stages of estrogen deficiency are still unknown...
August 14, 2018: Experimental and Clinical Endocrinology & Diabetes
Mohammed Jaber, Christian Ewelt, Johannes Wölfer, Benjamin Brokinkel, Christian Thomas, Martin Hasselblatt, Oliver Grauer, Walter Stummer
BACKGROUND: Approximately 20% of low-grade gliomas (LGG) display visible protoporphyrin fluorescence during surgery after 5-aminolevulinic acid (5-ALA) administration. OBJECTIVE: To determine if fluorescence represents a prognostic marker in LGG. METHODS: Seventy-four consecutive patients with LGG (World Health Organization 2016) were operated on with 5-ALA. Fluorescent tissue was specifically biopsied. Tumor size, age, Karnofsky index, contrast-enhancement, fluorescence, and molecular factors (IDH1/IDH2-mutations, Ki67/MIB1 Index, 1p19q codeletions, ATRX, EGFR, p53 expression, and O6-methylguanine DNA methyltransferase promotor methylation), were related to progression-free survival (PFS), malignant transformation-free survival (MTFS) and overall survival (OS)...
August 9, 2018: Neurosurgery
Felicity C Fitzgerald, Edouard Lhomme, Kathryn Harris, Julia Kenny, Ronan Doyle, Cissy Kityo, Liam B Shaw, George Abongomera, Victor Musiime, Adrian Cook, Julianne R Brown, Anthony Brooks, Ellen Owen-Powell, Diana M Gibb, Andrew J Prendergast, A Sarah Walker, Rodolphe Thiebaut, Nigel Klein
Objective: Immune activation is associated with morbidity/mortality in HIV-infection despite antiretroviral therapy (ART). We investigated whether microbial translocation drives immune activation in HIV-infected Ugandan children. Methods: Nineteen markers of immune activation/inflammation were measured over 96 weeks in HIV-infected Ugandan children in CHAPAS-3 (ISRCTN69078957) and HIV-uninfected age-matched controls. Microbial translocation was assessed using molecular techniques including next-generation sequencing...
August 11, 2018: Journal of Infectious Diseases
Emma L Feeney, Rebecca Barron, Victoria Dible, Zita Hamilton, Yvonne Power, Linda Tanner, Cal Flynn, Paul Bouchier, Tom Beresford, Nessa Noronha, Eileen R Gibney
Background: Dairy fat consumed as cheese has different effects on blood lipids than that consumed as butter. It is unknown whether the effect is specific to fat interaction with other cheese nutrients (calcium, casein proteins), or to the cheese matrix itself. Objective: We aimed to test the effect of 6 wk daily consumption of ∼40 g dairy fat, eaten within macronutrient-matched food matrices, on markers of metabolic health, in overweight adults aged ≥50 y. Design: The study was a 6-wk randomized parallel intervention; 164 volunteers (75 men) received ∼40 g of dairy fat/d, in 1 of 4 treatments: (A) 120 g full-fat Irish cheddar cheese (FFCC) (n = 46); (B) 120 g reduced-fat Irish cheddar cheese + butter (21 g) (RFC + B) (n = 45); (C) butter (49 g), calcium caseinate powder (30 g), and Ca supplement (CaCO3) (500 mg) (BCC) (n = 42); or (D) 120 g FFCC, for 6 wk (as per A) (n = 31)...
August 11, 2018: American Journal of Clinical Nutrition
Sang-Goo Lee, Aleksei E Mikhalchenko, Sun Hee Yim, Vadim N Gladyshev
Naked mole rats (NMRs, Heterocephalus glaber) are long-lived, cancer-resistant rodents. Here, we report the development of an induced pluripotent stem cell (iPSC) line generated from immortalized NMR embryonic fibroblasts transduced with a doxycycline-inducible mouse OSKM polycistronic vector. This iPSC line was shown to express pluripotency-associated markers, form embryoid bodies, differentiate in vitro to the derivatives of three germ layers, and exhibit normal karyotype. The ability of iPSCs to differentiate in vivo was supported by the contribution to interspecific chimera upon injection into mouse blastocysts...
June 20, 2018: Stem Cell Research
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