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molecularly imprinted

Xin-Lu Liu, Hong-Fei Yao, Mei-Hong Chai, Wei He, Yan-Ping Huang, Zhao-Sheng Liu
The facile fabrication of single-walled carbon nanotubes (SWCNTs)-doping molecularly imprinted polymer (MIP) nanocomposite-based binary green porogen system, room-temperature ionic liquids (RTILs), and deep eutectic solvents (DESs) was developed for drug delivery system. With fenbufen (FB) as template molecule, 4-vinylpyridine (4-VP) was used as functional monomer, ethylene glycol dimethacrylate as cross-linking monomer, and 1-butyl-3-methylimidazoliumtetrafluoroborate and choline chloride/ethylene glycol as binary green solvent, in the presence of SWCNTs...
October 15, 2018: AAPS PharmSciTech
Antonio D Hidalgo-Santos, Maria Del Carmen DeMingo-Alemany, Francisca Moreno-Macián, Mónica Roselló, Carmen Orellana, Francisco Martínez, Alfonso Caro-Llopis, Sara León-Cariñena, Miguel Tomás-Vila
Introduction: Schaaf-Yang syndrome (SYS) is caused by truncating point mutations of the paternal allele of MAGEL2 , an imprinted gene located in the critical region of Prader-Willi syndrome (PWS). These patients present a phenotype with neurodevelopmental delay, hypotonia, joint contractures, and a particularly high prevalence of autism (up to 75% in affected individuals). The loss of function of MAGEL2 is suggested to contribute to endocrine hypothalamic dysfunction in individuals with PWS...
July 2018: International Journal of Endocrinology and Metabolism
Merav Cohen, Amir Giladi, Anna-Dorothea Gorki, Dikla Gelbard Solodkin, Mor Zada, Anastasiya Hladik, Andras Miklosi, Tomer-Meir Salame, Keren Bahar Halpern, Eyal David, Shalev Itzkovitz, Tibor Harkany, Sylvia Knapp, Ido Amit
Lung development and function arises from the interactions between diverse cell types and lineages. Using single-cell RNA sequencing (RNA-seq), we characterize the cellular composition of the lung during development and identify vast dynamics in cell composition and their molecular characteristics. Analyzing 818 ligand-receptor interaction pairs within and between cell lineages, we identify broadly interacting cells, including AT2, innate lymphocytes (ILCs), and basophils. Using interleukin (IL)-33 receptor knockout mice and in vitro experiments, we show that basophils establish a lung-specific function imprinted by IL-33 and granulocyte-macrophage colony-stimulating factor (GM-CSF), characterized by unique signaling of cytokines and growth factors important for stromal, epithelial, and myeloid cell fates...
September 28, 2018: Cell
Tuanwei Liu, Zhenyun Qiao, Jilan Wang, Ping Zhang, Zhide Zhang, Dian-Shun Guo, Xinlin Yang
It is the goal for the development of cancer target chemotherapy with specific recognition, efficient killing the tumor cells and tissues to avoid the intolerable side effects. Molecular imprinted polymer (MIPs) nanoparticles could introduce kinds of specific bio-markers (template molecules) into the nanoparticles with the subsequent removal, leaving special holes in the structure with predictable recognition specificity with cells. Herein, we design and synthesize a kind of sialic acid (SA) over-expressed tumor target hollow double-layer imprinted polymer nanoparticles with S-nitrosothiols for nitric oxide (NO)-releasing as chemotherapy...
October 3, 2018: Colloids and Surfaces. B, Biointerfaces
Ameni Touati, Javier Errea-Dorronsoro, Sonia Nouri, Yosra Halleb, Arrate Pereda, Nabiha Mahdhaoui, Aida Ghith, Ali Saad, Guiomar Perez de Nanclares, Dorra H'mida Ben Brahim
AIM: 6q24-related transient neonatal diabetes mellitus (6q24-TNDM) is a rare imprinting disorder characterized by uncontrolled hyperglycemia during the first 6 months of life. The molecular etiology of 6q24-TNDM is attributable to overexpression of the paternally inherited PLAGL1 and HYMAI genes located on the 6q24 locus. One of these major defects is maternal loss of methylation (LOM) at 6q24. In addition, approximately 50% of TNDM patients that present LOM at 6q24 can also display hypomethylation at additional imprinted loci (multilocus imprinting disturbances, MLID)...
October 13, 2018: Acta Diabetologica
Moazameh Peyrovi, Mohammadreza Hadjmohammadi, Iman Saeidi
In the present study, a novel and efficient adsorbent constructed of molecularly imprinted polymer on the surface of modified magnetic nanoparticles with oleic acid (MNPs) was applied for the selective extraction of ezetimibe. The magnetic molecularly imprinted polymer (MMIP) was polymerized at the surface of modified MNPs using methacrylic acid (MAA) as functional monomer, ezetimibe as template and ethylene glycol dimethacrylate (EGDMA) as cross-linker. The resulting MMIP showed high adsorption capacity, good selectivity and fast kinetic binding for the template molecule...
October 12, 2018: Biomedical Chromatography: BMC
Elaheh Mansouri, Mahboobe Sarabi-Jamab, Behrouz Ghorani, Seyed Ahmad Mohajeri
Bulk polymerization method was used to prepare a homogeneous molecularly imprinted polymer (MIP) for the specific extraction of herbicide mecoprop (MCPP). Thereafter, the binding performance of this functional polymer was evaluated under optimal condition, compared to a non-imprinted polymer. From the Scatchard plot analysis, two types of binding sites were detected in the MIP, the high affinity binding sites with a KD (equilibrium dissociation constant) of 6.4 µM and the low affinity ones with a KD of 55...
October 11, 2018: Bulletin of Environmental Contamination and Toxicology
Xu Wang, Fang-Fang Yang, Li-Ping Zhang, Yan-Ping Huang, Zhao-Sheng Liu
Flotation drug delivery system (FDDS) is recognized as an efficient means to improve the therapeutic efficiency and enhance the drug bioavailability. Herein, we have developed a molecularly imprinted polymer (MIP) against capecitabine (CAP) to fabricate a FDDS by exploiting polyhedral oligomeric silsesquioxane (POSS) and Mobil composition of matter no. 41 (MCM-41) as the codopant. The synergistic effect of POSS and MCM-41 endows MIPs with enhanced imprinting effect and improved mass transfer efficiency. The impacts of the type of dopant, the type of functional monomer, the template/functional monomer ratio and the functional monomer/cross-linker ratio on imprinting effect have been investigated in detail...
October 12, 2018: Biomaterials Science
Liqin Hu, Tingting Zhou, Dan Luo, Jingwen Feng, Yun Tao, Yusun Zhou, Surong Mei
Recently, magnetic solid-phase extraction (MSPE) using magnetic molecularly imprinted polymers (MMIPs), which is a simple process with excellent selectivity, has attracted much attention for the determination of environmental pollutants. In this study, MMIPs were used as an adsorbent to establish a selective MSPE method coupled with high-performance liquid chromatography using ultraviolet detection (HPLC-UV) for the determination of tetrabromobisphenol A (TBBPA) levels in water and fish samples. The samples were collected from a laboratory-based fish-water system after 0, 2, 5, 8, 11, 20, 30, and 50 days...
February 10, 2019: Science of the Total Environment
Zengwei Li, Chan Lei, Na Wang, Xiongli Jiang, Yue Zeng, Zhenzhen Fu, Likou Zou, Li He, Shuliang Liu, Xiaolin Ao, Kang Zhou, Shujuan Chen
In this study, an efficient, selective, and simple analytical method for the extraction of chloramphenicol (CAP) from food using magnetic molecularly imprinted polymers (MMIPs) as the solid-phase extraction (SPE) sorbent was successfully developed. MMIPs with varying ratios of methacrylic acid to acrylamide were prepared by suspension polymerization on the surface of double-bond-modified Fe3 O4 magnetic nanoparticles. Further, these MMIPs were characterized by Fourier transform infrared spectroscopy and scanning electron microscopy, as well as using a vibrating sample magnetometer...
October 3, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Xiaoqiang Chen, Yu Luan, Ningwei Wang, Zhiping Zhou, Xiaoni Ni, Yunfei Cao, GuangShe Zhang, Yufeng Lai, Wenming Yang
Sulfadiazine is an environmental pollutant derived from abuse of antibiotics. Its content in environmental water is closely related to human health. Thus, a novel dual emission surface molecularly imprinted nanosensor is designed for specific adsorption and detection of sulfadiazine. In the system, blue emissive carbon quantum dots wrapped with silica served as the internal reference signal for eliminating background interference while red emissive thioglycolic acid-modified CdTe quantum dots were encapsulated in the imprinted layer to offer recognition signal...
October 11, 2018: Journal of Separation Science
Rebecca S DeVaux, Jason I Herschkowitz
Ductal Carcinoma in Situ (DCIS) is an early breast cancer lesion that is considered a nonobligate precursor to development of invasive ductal carcinoma (IDC). Although only a small subset of DCIS lesions are predicted to progress into a breast cancer, distinguishing innocuous from minacious DCIS lesions remains a clinical challenge. Thus, patients diagnosed with DCIS will undergo surgery with the potential for radiation and hormone therapy. This has led to a current state of overdiagnosis and overtreatment...
October 10, 2018: Journal of Mammary Gland Biology and Neoplasia
Esra Feyzioğlu, Emir Özçalışkan, Hayriye Karakaş, Murat Uygun, Deniz Aktaş Uygun, Sinan Akgöl, Adil Denizli
In this presented study, a novel molecularly imprinted polymeric hydrogel membranes (PHMs) were developed to use for the albumin depletion studies. For this, albumin imprinted poly(2-hydroxyethyl methacrylate-N-methacryloyl-(L)-phenylalanine methyl ester) polymeric hydrogel membranes [p(HEMA-MAP) PHMs] were synthesized by the photopolymerization technique, and then characterized by SEM, EDX, FT-IR and swelling studies. Synthesized PHMs had spherical structure and the MAP monomer incorporation onto the PHMs was determined by EDX analysis by using nitrogen stoichiometry...
October 10, 2018: Journal of Biomaterials Science. Polymer Edition
Lingling Du, Zhen Cheng, Panpan Zhu, Qian Chen, Yongqiong Wu, Kejun Tan
As a persistent organic pollutant, perfluorooctane sulfonate has drawn worldwide attention. In this contribution, a novel molecularly imprinted polymer based on mesoporous silica nanoparticles was prepared for efficient separation and enrichment of perfluorooctane sulfonate in water samples. The polymer was characterized by transmission electron microscopy, Fourier transform infrared spectra, X-ray diffraction and N2 adsorption/desorption experiments. The static adsorption experiments and the adsorption kinetic tests were conducted...
October 9, 2018: Journal of Separation Science
Xiaotong Feng, Jon Ashley, Tongchang Zhou, Yi Sun
A fluorometric assay is described for doxycycline detection. It is based on the use of nitrogen-doped carbon quantum dots (NCQDs) coated with molecularly imprinted polymers (MIPs). The NCQDs were prepared by a one-step hydrothermal reaction using citric acid and ethylenediamine (EDA) as the starting materials. Afterwards, the NCQDs were incorporated into the polymer that was molecularly imprinted with doxycycline. It is found that doxycycline quenches the fluorescence of the NCQDs, and that the functional groups on the surface of NCQDs play an important role in terms of quenching efficiency...
October 6, 2018: Mikrochimica Acta
Brian P Bloom, Ruibin Liu, Peng Zhang, Supriya Ghosh, Ron Naaman, David N Beratan, David H Waldeck
The optical and electronic properties of semiconductor quantum dots (QDs) make them attractive candidates for applications in photovoltaics, spintronics, photocatalysis, and optoelectronics. Understanding how to control the flow of charge in QD assemblies is essential for realizing novel applications. This Account explores some unique characteristics of charge transport in QD dyads, triads, and their assemblies. The emerging features of these assemblies that provide new opportunities to manipulate charge flow at the nanoscale are (1) cascading energy landscapes and band offsets to inhibit charge recombination, (2) electrostatic fields that direct charge flow through QD-QD and QD-conjugated polymer junctions, and (3) QD chirality and chiral imprinting that promotes vectorial electron and spin selective transport...
October 5, 2018: Accounts of Chemical Research
Shengnan Xu, Ligang Chen, Ling Ma
The authors describe a fluorescent probe for sensitive and selective determination of quercetin, an indicator for the freshness of drinks. The probe consists of silica ball encapsulated graphitic carbon nitride (g-C3 N4 ) modified with a molecularly imprinted polymer (MIP). It was synthesized via reverse microemulsion. The resulting MIP@g-C3 N4 nanocomposite was characterized by fluorescence spectroscopy, transmission electron microscopy, Fourier transform infrared spectroscopy, and X-ray powder diffraction...
October 3, 2018: Mikrochimica Acta
Guizhen Li, Kyung Ho Row
A ternary deep eutectic solvent (TDES) was used as both template and functional monomer in the synthesis of TDES-based molecularly imprinted polymers (TDES-MIPs). A meticulous miniaturized solid-phase microextraction (mini-SPME) method followed by high-performance liquid chromatography (HPLC) were used for the optimal speciation of 3,4-dihydroxybenzoic acid (3,4-DHBA) in the needle of a syringe system with response surface methodology (RSM). Under the optimal conditions for the determination of 3,4-DHBA (amount of adsorbent (2 mg), sample volume (1 mL), cycles for adsorption and desorption (6)), the actual extraction amount was 8...
October 3, 2018: Analytical and Bioanalytical Chemistry
Jessica Tome-Garcia, Parsa Erfani, German Nudelman, Alexander M Tsankov, Igor Katsyv, Rut Tejero, Bin Zhang, Martin Walsh, Roland H Friedel, Elena Zaslavsky, Nadejda M Tsankova
The intrinsic drivers of migration in glioblastoma (GBM) are poorly understood. To better capture the native molecular imprint of GBM and its developmental context, here we isolate human stem cell populations from GBM (GSC) and germinal matrix tissues and map their chromatin accessibility via ATAC-seq. We uncover two distinct regulatory GSC signatures, a developmentally shared/proliferative and a tumor-specific/migratory one in which TEAD1/4 motifs are uniquely overrepresented. Using ChIP-PCR, we validate TEAD1 trans occupancy at accessibility sites within AQP4, EGFR, and CDH4...
October 1, 2018: Nature Communications
Yan-Ling Liu, Rong Liu, Yu Qin, Quan-Fa Qiu, Zhen Chen, Shi-Bo Cheng, Wei-Hua Huang
Flexible electrochemical (EC) sensors have shown great prospect in epidermal detection for personal healthcare and disease diagnosis. However, no reports have been seen in flexible device for urea analysis in body fluids. Herein, we developed a flexible wearable EC sensor based on surface molecularly imprinted nanotubes for non-invasive urea monitoring with high selectivity in human sweat. The flexible EC sensor was prepared by electropolymerization of 3,4-ethylenedioxythiophene (EDOT) monomer on the hierarchical network of carbon nano-tubes (CNTs) and gold nanotubes (Au NTs) to imprint template molecule urea...
October 1, 2018: Analytical Chemistry
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