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Chinese herbal medicines

Yu Xia, Bo Yu, Chaozhi Ma, Yijun Tu, Ling Zhai, Yanfang Yang, Dan Liu, Yanwen Liu, Hezhen Wu, Hanxiong Dan, Pengtao You
Yu Gan Long (YGL) is a Chinese traditional herbal medicine that has been used in the treatment of liver fibrosis for many years in clinical practice. However, its anti-hepatofibrotic mechanism has not been studied yet. In this study, the effect and mechanism of YGL in reducing liver fibrosis was demonstrated in vivo. Our results showed that liver fibrosis biomarkers collagen IV (Col IV), type III precollagen (PCIII), hyaluronuc acid (HA) and laminin (LN), were increased after CCl4 treatment and decreased by YGL...
July 21, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Kuan-Yu Chen, Mei-Yao Wu, Pei-Shan Yang, Jen-Huai Chiang, Chung-Y Hsu, Chiu-Ying Chen, Hung-Rong Yen
ETHNOPHARMACOLOGICAL RELEVANCE: Traditional Chinese medicine (TCM) has been used for over two thousand years to treat motor impairments corresponding to the clinical manifestations of Parkinson's disease (PD). AIM OF THE STUDY: This study aimed to investigate the prescription of Chinese herbal medicine (CHM) for the management of PD and further determine whether CHM can improve motor function and decrease the risk of incident fracture. MATERIALS AND METHODS: Patients older than 40 years newly diagnosed with PD between January 1997 and December 2010 were selected from the National Health Insurance Research Database (NHIRD) and followed up until the end of 2013...
August 14, 2018: Journal of Ethnopharmacology
Dong-Sheng Zhao, Zi-Tian Wu, Zhuo-Qing Li, Ling-Li Wang, Li-Long Jiang, Wei Shi, Ping Li, Hui-Jun Li
ETHNOPHARMACOLOGICAL RELEVANCE: Dioscorea bulbifera rhizome (DBR), one type of herbal medicine, is extensively used in both Indian and Chinese system of traditional medicine. It has been effective in treating various diseases, such as sore throat, struma, and tumors. However, more and more clinical investigations have suggested that DBR can cause liver injury. AIM OF THE STUDY: In the present study, we aimed to characterize the corresponding molecular changes of liver dysfunction and reveal overall metabolic and physiological mechanisms of the subchronic toxic effect of DBR...
August 13, 2018: Journal of Ethnopharmacology
Ying Nie, Weifeng Yao
The quantitative analysis of multiple indexes remains an important quality evaluation method of traditional Chinese medicine (TCM) herbal formulas. The Chinese Pharmacopoeia 2015 only stipulates the content of a single component, specnuezhenide, in Erzhiwan composed of the Fructus Ligustri Lucidi (FLL) powder and aqueous extracts of Herba Ecliptae (HE). To generalize the intrinsic quality of Erzhiwan, a novel C30 -HPLC method with good precision, accuracy, and reproducibility was developed for the simultaneous determination of six compounds, including two isomers, and then an analytic hierarchy process was further applied to integrate and discriminate the quality of four samples prepared via different methods...
August 15, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Jin-Hui Tian, Shu-Zhen Shi, Ye Zhao, Wen-Juan Ma, Rui-Feng Liu, Xiao-Hu Wang, Jun-Hua Zhang
To mainly analyze the prescription rules of Chinese herbal drugs for radiation induced lung injury, optimize the prescriptions, and provide a reference for the clinical treatment of radiation induced lung injury. The major Chinese databases CNKI, CBM and Wanfang data were searched to obtain the literature on Chinese herbal drugs for radiation induced lung injury. BICOMS 2 software was used to extract and collect all Chinese herbal drugs information and generate the co-occurrence matrix; NetDraw and Gcluto software were then used to make network map and visualization matrix for analysis...
July 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Ya-Jing Zhang, Tao Wang, Qiao-Sheng Guo, Qing-Jun Zou, Meng-Lu Zhao, Zheng-Zhou Han, Min Wei
ICP-MS was used to determine the contents of five heavy metals such as lead (Pb), cadmium (Cd), mercury (Hg), arsenic (As) and copper (Cu) in Chrysanthemum indicum and soil samples. Pearson correlation and path analysis were used to analyze the effects of latitude and longitude and altitude on the content of heavy metal elements in Ch. indicum. To explore the relationship between geographical location of heavy metal content in Ch. indicum and the content of heavy metal elements in soil. The results showed that the Ch...
July 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Dan-Dan Mo, Jun-Hui Liu, Hai-Bing Qiu, Shan-Mei Su, Hua-Zhen Qin, Jun-Qi Chen, You Yin, Ming-Fang Li
In order to explore the correlation between the medicinal properties,efficacy and application in the same genetic relationship,explain the scientific connotation of the medicinal properties and effects of traditional Chinese medicines(TCM),promote the academic development of the theory of traditional Chinese medicines,and provide reference for the research and development of the traditional Chinese medicines of a same genus. In this paper, a literature study of ancient and modern works of Chinese herbal medicine was conducted to investigate the correlation between the properties, meridians tropism, efficacy and application of Alpinia officinarum, A...
July 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Yangyang Xu, Hao Cai, Gang Cao, Yu Duan, Ke Pei, Jia Zhou, Li Xie, Jiayu Zhao, Jing Liu, Xiaoqi Wang, Lin Shen
To characterize the chemical differences of volatile components between crude and processed Baizhu Shaoyao San (BSS), a classical Chinese herbal formula that is widely applied in the treatment of gastrointestinal diseases, we developed a gas chromatography-mass spectrometry-based needle trap device combined with multivariate data analysis to globally profile volatile components and rapidly identify differentiating chemical markers. Using a triple-bed needle packed with Carbopack X, DVB and Carboxen 1000 sorbents, we identified 121 and 123 compounds, respectively, in crude and processed BSS...
June 2018: Royal Society Open Science
Chung-Wah Cheng, Li Zhang, Chen Zhao, Linda Ld Zhong, Li-Jie Shi, Liang Dai, Rui Zheng, Jing Chen, Ge Li, Jing-Bo Zhai, Wai Kun, Ai-Ping Lu, Hong-Cai Shang, Zhao-Xiang Bian
BACKGROUND: Syndrome is one of the most important concepts in Chinese medicine (CM) theory. However, it was not well accounted in most of randomized controlled trials (RCTs). OBJECTIVE: To determine whether CM syndrome differentiation affects the treatment results, functional constipation (FC) was selected as a target disease, and MaZiRenWan (, MZRW), a classic CM formula commonly used for constipation with excessive heat syndrome, was selected for study. METHODS: It is an 18-week prospective double-blinded, doubledummy RCT, including 2-week run-in, 8-week treatment and 8-week post treatment follow-up...
August 14, 2018: Chinese Journal of Integrative Medicine
Bumjung Kim, Cheolmin Jo, Ho-Young Choi, Kyungjin Lee
Historically, traditional herbal medicines (THMs) have been the conventional treatment strategy in the Korean medical system for treating many diseases. However, THMs have rarely been used to treat hypertension, and moreover few studies have investigated the interaction of blood pressure with the coadministration of synthetic antihypertensives. We aimed to evaluate the vasorelaxant and hypotensive effects of the traditional herbal prescription Cheonwangbosimdan (CWBSD; "Tianwangbuxindan" in Chinese) and the combination of CWBSD with amlodipine...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Xiaoying Sun, Lilan Sun, Hang Qi, Qin Gao, Gongxin Wang, Ningning Wei, Kewei Wang
Coumarin osthole is a dominant bioactive ingredient of natural Cnidium monnieri plant commonly used as traditional Chinese herbal medicines for therapies and treatments including antipruritus and antidermatitis. However, the molecular mechanism underlying the action of osthole remains unclear. In this study we report that osthole exerts antipruritic effect through selective inhibition of Ca2+-permeable and thermosensitive TRPV3 cation channels that are primarily expressed in the keratinocytes of the skin. Coumarin osthole was identified as an inhibitor of TRPV3 channels transiently expressed in HEK293 cells in the calcium fluorescent FlexStation assay...
August 14, 2018: Molecular Pharmacology
Ming-Yii Huang, Chia-En Tu, Shu-Chi Wang, Yung-Li Hung, Chia-Cheng Su, Shih-Hua Fang, Chi-Shuo Chen, Po-Len Liu, Wei-Chung Cheng, Yu-Wei Huang, Chia-Yang Li
BACKGROUND: Inflammation has been found to be associated with many neurodegenerative diseases, including Parkinson's and dementia. Attenuation of microglia-induced inflammation is a strategy that impedes the progression of neurodegenerative diseases. METHODS: We used lipopolysaccharide (LPS) to simulate murine microglia cells (BV2 cells) as an experimental model to mimic the inflammatory environment in the brain. In addition, we examined the anti-inflammatory ability of corylin, a main compound isolated from Psoralea corylifolia L...
August 15, 2018: BMC Complementary and Alternative Medicine
Xiaojiao Duan, Jiarui Wu, Xingyue Huang, Kaihuan Wang, Yi Zhao, Dan Zhang, Xinkui Liu, Xiaomeng Zhang
Introduction: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) imposes a huge economic burden on healthcare systems worldwide. Chinese herbal injections (CHIs) are widely used to treat AECOPD. In this study, we examined the efficacy of CHIs in the treatment of AECOPD using a network meta-analysis (NMA). Methods: Literature search was conducted from electronic databases of randomized controlled trials (RCTs) on CHIs plus Western medicine (WM) versus WM...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Xiaolong Xu, Qingquan Liu, Shasha He, Jingxia Zhao, Ning Wang, Xuyang Han, Yuhong Guo
Sepsis is reported to be an unusual systemic reaction to infection, accompanied by multiple-organ failure. Sepsis-induced cardiomyopathy (SIC), defined as damages and dysfunction of the heart, is essential in the pathogenesis of sepsis. Traditional Chinese formula, which has long been used to improve the situation of patients through multitarget regulation, is now gradually being used as complementary therapy. The present study aimed to investigate the effect of Qiang-Xin 1 (QX1) formula, a traditional Chinese herbal medicine designed for cardiac dysfunction, on cecal ligation puncture (CLP)-induced heart damage and its underlying mechanisms in mice...
2018: Frontiers in Pharmacology
Zhi Liu, Xin He, Lili Wang, Yunhua Zhang, Yue Hai, Rui Gao
This review summarizes the current research status of hepatotoxicity and points out that drug induced liver injury (DILI) remains an important scientific problem that urgently needs to be solved. Due to the special nature of Chinese Herbal medicine and the complexity of its clinical use, it is difficult to identify and evaluate its toxicity and resulting herb induced liver injury (HILI). At the same time, due to a lack of specific indicators, the direct and indirect long-term effects of Chinese Herbal Medicine on the liver are also difficult to be clinically determined...
August 13, 2018: Current Drug Metabolism
Shu-Han Qu, Ji-Ping Zhao, Sheng Chen, Zhi-Hong Wen, Yi Zhang, Xue-Si Hou, Wei-Mei Zeng, Yi-Fan Jia, Xiang-Hong Jing
OBJECTIVE: To evaluate the clinical effect of herbal cake-partitioned moxibustion combined with medication in the treatment of moderate and severe persistent allergic rhinitis (PAR) patients of spleen deficiency pattern. METHODS: Sixty patients with moderate and severe PAR of spleen deficiency pattern were randomized into medication (Rhinocort) group and herbal cake-partitioned moxibustion combined with medication group (combination group, n =30 cases in each). Medicinal cake-partitioned moxibustion was applied to Yintang (GV 29, for about 20 min), Shenque(CV 8, about 50 min), bilateral Zusanli (ST 36, about 40 min)and Hegu(LI 4, about 40 min)once every other day for successive 8 weeks...
July 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
Wen-Ting Wang, Hua Zhang, Yuan Yuan, Ya Guo, Shi-Xin He
Raman spectroscopy is a spectroscopic analysis technique that enables rapid qualitative and quantitative detection based on inelastic collision and Raman scattering intensity. This review detailed the generation principle, instrument composition, influencing factors, and common classifications of Raman spectrum. Furthermore, it summarized and forecast the research progress of Raman spectroscopy in the field of drug analysis simultaneously over the past decade, including the identification of active pharmaceutical ingredients (APIs), qualitative and quantitative studies of pharmaceutical preparations, detection of illicit drugs, the identification of Chinese herbal medicines, and the combination with other technologies...
August 8, 2018: AAPS PharmSciTech
Farshad Homayouni Moghadam, Mehrnaz Mesbah-Ardakani, Mohammad Hossein Nasr-Esfahani
Objectives: Based on data from Chinese and Indian traditional herbal medicines, gum resin of Ferula assa-foetida (sometimes referred to asafetida or asafoetida) has several therapeutic applications. The authors of various studies have claimed that asafetida has cytotoxic, antiulcer, anti-neoplasm, anti-cancer, and anti-oxidative effects. In present study, the anti-aging effect of asafetida on senescent human dermal fibroblasts was evaluated. Methods: Senescence was induced in in vitro cultured human dermal fibroblasts (HDFs) through exposure to H2 O2 , and the incidence of senescence was recognized by using cytochemical staining for the activity of β -galactosidase...
September 2017: Journal of Pharmacopuncture
Renjin Lin, Jinti Lin, Shihen Li, Jian Ding, Hongqiang Wu, Guangheng Xiang, Shi Li, Yijia Huang, Dingsheng Lin, Weiyang Gao, Jianzhong Kong, Huazi Xu, Kailiang Zhou
Background: Random skin flaps are routinely placed during plastic and reconstructive surgery, but the distal areas often develop ischemia and necrosis. Baicalein, a major flavonoid extracted from the traditional Chinese herbal medicine huangqin, Scutellaria baicalensis Georgi, may improve flap viability. Materials and methods: Rats were randomly divided into baicalein and control groups and they underwent placement of modified McFarlane flaps after intraperitoneal administration of baicalein or vehicle...
2018: Drug Design, Development and Therapy
Ye Wang, Heng-Yu Huang, Zhi-Tian Zuo, Yuan-Zhong Wang
Dendrobium officinale, as a tonic herb, has attracted more and more consumers to consume in daily life. In order to protect the wild resource, the herb has made great progress though cultivation in vitro. However, the quality is fluctuated in Chinese herbal medicine market due to influence such as cultivated areas and harvesting period. Therefore, the herbal samples from different cultivated locations were evaluated with high-performance liquid chromatography with diode array detector (HPLC-DAD) in terms of two chemical components, quercetin and erianin...
August 1, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
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