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Chinese herbal medicines

Taro Nonaka, Makiko Takahashi, Chika Nonaka, Kazufumi Haino, Masayuki Yamaguchi, Takayuki Enomoto, Koichi Takakuwa
AIM: Recently, it is widely recognized that positivity for anti-phospholipid antibodies is a causative factor for a range of reproductive failures. Anti-cardiolipin beta2 glycoprotein I antibody (anti-CL-beta2-GPI) is a representative anti-phospholipid antibody, which strongly correlates with the development of thrombotic events and diversity of adverse pregnancies. In this series, we aimed to elucidate effective treatment for patients with recurrent fetal losses positive for anti-CL-beta2-GPI using Japanese-modified Chinese herbal medicine...
December 4, 2018: Journal of Obstetrics and Gynaecology Research
Kun Liu, Xiu-Mei Ren, Qing-Sheng You, Ming-Ming Gu, Fei Wang, Shuo Wang, Chun-Hui Ma, Wei-Nan Li, Qing Ye
Dangguibuxue decoction (DBD), a kind of Chinese herbal medicine, has been widely used to treat blood deficiency disease in China. In this experiment, we studied the effects of the Dangguibuxue decoction (DBD) on the myocardial injury induced by cyclophosphamide in mice. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatine kinase (CK), and lactic dehydrogenase (LDH) in serum were detected by commercial kits. Total white blood cell (WBCs), platelets, and cytokines pathological changes of heart tissue were also examined...
2018: BioMed Research International
Kunlun Li, Jiaoyang Luo, Tong Ding, Xiaowen Dou, Yuli Hu, Xingguo Zhang, Meihua Yang
Bupleuri Radix is a famous traditional Chinese medicine (TCM) and an important raw material in TCM patent prescriptions. It is widely used in several countries, including China, Japan, South Korea, and America. However, the impact of heavy metal transfer rules on TCMs remains unknown. In this study, a total of 45 paired original medicines (OMs), decoction pieces (DPs), and vinegar-processed (VPs) samples were simultaneously determined via inductively coupled plasma-mass spectrometry after a microwave digestion...
November 2018: Food Science & Nutrition
I-Cheng Chen, Te-Hsien Lin, Yu-Hsuan Hsieh, Chih-Ying Chao, Yih-Ru Wu, Kuo-Hsuan Chang, Ming-Chung Lee, Guey-Jen Lee-Chen, Chiung-Mei Chen
Misfolded tau proteins induce accumulation of free radicals and promote neuroinflammation by activating microglia-releasing proinflammatory cytokines, leading to neuronal cell death. Traditional Chinese herbal medicines (CHMs) have been widely used in clinical practice to treat neurodegenerative diseases associated with oxidative stress and neuroinflammation. This study examined the neuroprotection effects of formulated CHMs Bai-Shao (made of Paeonia lactiflora ), Gan-Cao (made of Glycyrrhiza uralensis ), and Shaoyao Gancao Tang (SG-Tang, made of P...
2018: Oxidative Medicine and Cellular Longevity
Wing Lam, Yongshen Ren, Fulan Guan, Zaoli Jiang, William Cheng, Chang-Hua Xu, Shwu-Huey Liu, Yung-Chi Cheng
YIV-906 (PHY906), a four-herb Chinese medicine formulation, is inspired by an 1800 year-old Chinese formulation called Huang Qin Tang which is traditionally used to treat gastrointestinal (GI) symptoms. In animal studies, it could enhance anti-tumor activity of different classes of anticancer agents and promote faster recovery of the damaged intestines following irinotecan or radiation treatment. Several clinical studies have shown that YIV-906 had the potential to increase the therapeutic index of cancer treatments (chemotherapy, radiation) by prolonging life and improving patient quality of life...
2018: Frontiers in Pharmacology
Wanjun Yan, Xingcong Ma, Xiaoyao Zhao, Shuqun Zhang
Purpose: Baicalein, a widely used Chinese herbal medicine, has shown anticancer effects on many types of human cancer cell lines. However, little is known about the underlying mechanism in human breast cancer cells. In this study, we examined the apoptotic and autophagic pathways activated following baicalein treatment in human breast cancer cells in vitro and in vivo. Materials and methods: In in vitro study, we used MTT and clone formation assay to confirm the inhibitory role of baicalein on proliferation of MCF-7 and MDA-MB-231 breast cancer cells...
2018: Drug Design, Development and Therapy
Changgeng Fu, Dexin Yin, Haiying Nie, Dajun Sun
BACKGROUND/AIMS: Radix notoginseng is a well-known traditional Chinese herbal medicine, has extensively pharmacological activities in cardiovascular system. Notoginsenoside R1 (NGR1) is one main active ingredient of Radix notoginseng. The purpose of this study was to evaluate the functional effects of NGR1 on atherosclerosis (AS). METHODS: Human umbilical vascular endothelial cells (HUVECs) were subjected to oxidized low density lipoprotein (ox-LDL), before which cells were preconditioned with NGR1...
November 30, 2018: Cellular Physiology and Biochemistry
Jia Zhou, Hao Cai, Sicong Tu, Yu Duan, Ke Pei, Yangyang Xu, Jing Liu, Minjie Niu, Yating Zhang, Lin Shen, Qigang Zhou
Sinisan has been widely used to treat depression. However, its pharmacologically-effective constituents are largely unknown, and the pharmacological effects and clinical efficacies of Sinisan-containing processed medicinal herbs may change. To address these important issues, we developed an ultra-high performance liquid chromatography coupled with electrospray ionization tandem quadrupole-time-of-flight mass spectrometry (UHPLC-Q-TOF/MS) method coupled with multiple statistical strategies to analyze the compound profiles of Sinisan, including individual herb, herb-pair, and complicated Chinese medicinal formula...
November 29, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Yu-Chiang Hung, Chieh-Ying Chin, Yi-Chiao Lee, Yen-Hao Chen, Ming-Yen Tsai
BACKGROUND: To summarize the clinical efficacy and safety of Chinese herbal medicine (CHM) in the treatment of dermatologic events resulting from epidermal growth factor receptor (EGFR) inhibitors according to our experience of ten patients. METHODS: Four males and six females, 35-73 years old, mainly with acneiform rash associated with EGFR inhibitors on the face, scalp, perineum, four limbs, and upper trunk, were treated at our traditional Chinese medicine (TCM) clinic in 2016 and 2017...
November 6, 2018: Explore: the Journal of Science and Healing
Rendan Zhang, Tudi Li, Jiao Guo, Yanqun Zhao, Yuhong Liu, Yusi Yao, Zhihuan Zeng
BACKGROUND: To investigate the effects of a Chinese herbal medicine Fufang-Zhenzhu Tiaozhi Capsule (FTZ) on restenosis and elucidate the mechanism of action. METHODS: A restenosis model was established by balloon rubbing the endothelium of the abdominal aorta followed by high fat diet. Rabbits were divided into blank control group, restenosis group, FTZ group (0.66 mg/kg/day), atorvastatin group (5 mg/kg/day) and FTZ + atorvastatin group (n = 8). Vascular stenosis was analyzed by X-ray...
November 30, 2018: Lipids in Health and Disease
Su-Tso Yang, Yi-Rong Lin, Mei-Yao Wu, Jen-Huai Chiang, Pei-Shan Yang, Te-Chun Hsia, Hung-Rong Yen
BACKGROUND: Tuberculosis (TB) is one of the world's major communicable infectious diseases, and it still imposes a great health burden in developing countries. The development of drug-resistant TB during the treatment increases the treatment complexity, and the long-term pulmonary complications after completing treatment raise the epidemic health burden. This study intended to investigate the utilization of Chinese medicine (CM) for respiratory symptoms by patients with a medical history of TB in Taiwan...
November 29, 2018: BMC Complementary and Alternative Medicine
Yu Li, Jian-Guo Jiang
Anthraquinone compounds with the anthraquinone ring structure are widely found in traditional Chinese medicines and they are attracting a lot of attention due to their good pharmacological activity. Diversities of anthraquinones depend on their chemical structures, such as the number of anthraquinone rings and the substituents; what's more, the difference in chemical structure determines the difference in physiological activity. Based on results of previous studies, this review summarizes several natural anthraquinones identified from Chinese herbal medicines and their physiological activities including anti-cancer, anti-pathogenic microorganisms, anti-inflammatory, anti-oxidation, anti-osteoporosis, anti-depression, and anti-constipation...
November 28, 2018: Food & Function
Liang Dai, Chung-Wah Cheng, Ran Tian, Linda Ld Zhong, You-Ping Li, Ai-Ping Lyu, An-Wen Chan, Hong-Cai Shang, Zhao-Xiang Bian
Traditional Chinese Medicine (TCM) is one of the oldest systems of medicine. More and more attention has been paid to TCM application, but the variable quality of clinical trials with TCM impedes its widespread acceptance. The Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) 2013 Statement has established guidelines for designing clinical trials to ensure that the trial results are accurate and reliable. However, there are difficulties when applying SPIRIT 2013 Statement to trials with TCM, due to the unique theory and the characteristic of TCM intervention...
November 27, 2018: Chinese Journal of Integrative Medicine
Jun-Li Chang, Wen-Yi Wang, Yi-Mian Li, Shao-Pu Hu, Min Yao, Xue-Jun Cui, Wen-Lan Zhi, Qi Shi, Yong-Jun Wang, Yan-Ping Yang
OBJECTIVE: To summarize and critically assess the inhibitory effects of Chinese herbal medicine (CHM) on tumor volume and tumor weight for the treatment of osteosarcoma (OS) in mouse models. METHODS: PubMed, Embase, Web of Science, China Knowledge Resource Integrated Database (CNKI), Wanfang Database, VIP Database, and Chinese BioMedical (CBM) were searched since their inception dates to March 10, 2016. Two reviewers independently selected the controlled studies estimating effects of CHM on mouse OS by administration in vivo...
November 27, 2018: Chinese Journal of Integrative Medicine
Xin-Hui Lu, Jun Li
OBJECTIVE: To summarize the current evidence for 8 frequently prescribed Chinese herbal formulas (CHF) as treatments for angina pectoris in patients with coronary heart disease (CHD) and the associated adverse reactions. METHODS: Seven electronic databases were screened from their inception through July 2018 for all evidence related to classical CHF for the treatment of patients with CHD. RESULTS: CHF improves CHD outcomes in terms of angina pectoris, electrocardiogram results, Chinese medicine syndromes and biomarkers iomarkers...
November 27, 2018: Chinese Journal of Integrative Medicine
Hong Wei Zhang, Zhi Xiu Lin, Fan Cheung, William Chi-Shing Cho, Jin-Ling Tang
BACKGROUND: Moxibustion, a common treatment in traditional Chinese medicine, involves burning herbal preparations containing Artemisia vulgaris on or above the skin at acupuncture points. Its intended effect is to enhance body function, and it could reduce the side effects of chemotherapy or radiotherapy and improve quality of life (QoL) in people with cancer. OBJECTIVES: To assess the effects of moxibustion for alleviating side effects associated with chemotherapy, radiotherapy or both in people with cancer...
November 13, 2018: Cochrane Database of Systematic Reviews
M Ortiz, M Teut, E Ben-Arye, A Reshef, M Kaffman, Z Arnon, B Stöckigt, V Bähr, L Meoded-Danon, B Brinkhaus, E Schiff
INTRODUCTION: Communication is an essential component of patient care, and although medical schools provide training on this topic, patients and physicians alike express the need to improve their communication skills. An international medical student collaboration explored whether complementary medicine (CM) has the ability to further enhance patient-doctor communication. METHODS: Twenty-two medical students, nine mentors and two public representatives from Israel and Germany participated in this 18-month international group project...
December 2018: Complementary Therapies in Medicine
Yujie Shang, Su Lu, Yun Chen, Xiumei Sun
OBJECTIVE: Chinese herbal medicines (CHM) have been the mainstream therapy in Asia for thousands of years and become more popular as the alternative treatment recently. The objective of this study is to evaluate the efficacy and safety of CHM for non-structural abnormal uterine bleeding (AUB) in perimenopause. METHODS: Seven databases were searched from inception to December 31 st, 2017. Randomized controlled trials (RCTs) which compared CHM versus western therapy in treating non-structural AUB in perimenopause were extracted...
December 2018: Complementary Therapies in Medicine
Mengyue Guo, Wenjun Jiang, Jiaoyang Luo, Meihua Yang, Xiaohui Pang
Ziziphi Spinosae Semen (ZSS) has been widely used in traditional Chinese medicine system for decades. Under proper humidity and temperature, ZSS is easily contaminated by fungi and mycotoxins during harvest, storage, and transport, thereby posing a considerable threat to consumer health. In this study, we first used the Illumina MiSeq PE250 platform and targeted the internal transcribed spacer 2 sequences to investigate the presence of fungi in moldy and normal ZSS samples collected from five producing areas in China...
November 25, 2018: Toxins
Zhili Xiong, Lang Lang, Xun Gao, Wei Xiao, Zhenzhong Wang, Longshan Zhao
Guizhi Fuling capsule (GFC) was an important traditional Chinese herbal medicine used for the treatment of primary dysmenorrheal (PD). The aim of this study was to evaluate the anti-dysmenorrheal effect of GFC on dysmenorrheal rats induced by oxytocin and to investigate its mechanism of action. An integrative urinary metabolomic study based on 1 H NMR and UPLC-MS was used to investigate the therapeutic effect of GFC on PD rats. In addition, in order to obtain more potential biomarkers and to investigate the global urine metabolic profile associated with PD, we combined the characteristics of RP-UPLC-MS with HILIC-UPLC-MS on metabolomic platform to find non-polar and polar metabolites...
November 17, 2018: Journal of Pharmaceutical and Biomedical Analysis
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