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Acute kidney injury, children

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https://www.readbyqxmd.com/read/30095579/acute-kidney-injury-may-not-be-as-uncommon-as-believed-in-children-with-advanced-chronic-liver-diseases
#1
Bikrant Bihari Lal, Priti Vijay, Vikrant Sood, Rajeev Khanna, Seema Alam
No abstract text is available yet for this article.
August 8, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30085171/rhabdomyolysis-in-children-three-exotic-presentations-from-suriname
#2
Kevin van 't Kruys, Rens Zonneveld, Safir Liesdek, Wilco Zijlmans
We describe three clinical cases of Surinamese children with rhabdomyolysis with diverse clinical presentation and course. The first patient had rhabdomyolysis because of toxins caused by multiple beestings and developed acute kidney injury. The other two patients had rhabdomyolysis following acute infection with chikungunya and influenza A/H1N1 virus. These cases emphasize that the diverse etiology of rhabdomyolysis should be considered in children in tropical settings.
July 30, 2018: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/30084780/modified-peritoneal-dialysis-for-treatment-of-acute-renal-failure-after-complex-congenital-heart-surgery-in-infants
#3
Lefeng Zhang, Yongqiang Jin, Fuqiang Zhang, Hongyin Li, Qingyu Wu
BACKGROUND: Acute kidney injury (AKI) is one of the common complications in infants and children after complex congenital heart surgery. Peritoneal dialysis (PD) is usually applied for renal replacement therapy (RRT), especially in infants. We investigated the efficacy and safety of modified PD for the treatment of acute renal failure and congestive heart failure after cardiac surgery for congenital heart disease in infants.  Methods: We retrospectively analyzed five consecutive patients from October 2015 to February 2017...
June 25, 2018: Heart Surgery Forum
https://www.readbyqxmd.com/read/30078024/outcome-of-continuous-renal-replacement-therapy-in-critically-ill-children-a-retrospective-cohort-study
#4
Tareq Al-Ayed, Naveed Ur Rahman, Abdullah Alturki, Fahad Aljofan
BACKGROUND: Continuous renal replacement therapy (CRRT) has become the preferred mode of dialysis to support critically ill children with acute kidney injury. However, there are limited pediatric data on CRRT use, especially in our region. OBJECTIVE: Determine the outcome of CRRT among critically ill children. DESIGN: Retrospective cohort study. SETTING: Pediatric intensive care unit. PATIENTS AND METHODS: The study included critically ill children 1-14 years of age who underwent CRRT from July 2009 to June 2015...
July 2018: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/30075198/acute-kidney-injury-after-out-of-hospital-pediatric-cardiac-arrest
#5
Timothy T Cornell, David T Selewski, Jeffrey A Alten, David Askenazi, Julie C Fitzgerald, Alexis Topjian, Richard Holubkov, Kent Page, Beth S Slomine, James R Christensen, J Michael Dean, Frank W Moler
IMPORTANCE: Many children with return of spontaneous circulation (ROSC) following cardiac arrest (CA) experience acute kidney injury (AKI). The impact of therapeutic hypothermia on the epidemiology of post-CA AKI in children has not been fully investigated. OBJECTIVE: The study aims were to: 1) describe the prevalence of severe AKI in comatose children following out-of-hospital CA (OHCA), 2) identify risk factors for severe AKI, 3) evaluate the impact of therapeutic hypothermia on the prevalence of severe AKI, and 4) evaluate the association of severe AKI with survival and functional outcomes...
July 31, 2018: Resuscitation
https://www.readbyqxmd.com/read/30073844/toxicity-of-muscimol-and-ibotenic-acid-containing-mushrooms-reported-to-a-regional-poison-control-center-from-2002-2016
#6
Michael J Moss, Robert G Hendrickson
BACKGROUND: Amanita muscaria (AM) and A. pantherina (AP) contain ibotenic acid and muscimol and may cause both excitatory and sedating symptoms. Gastrointestinal (GI) symptoms are not classically described but have been reported. There are relatively few reported cases of poisoning with these mushrooms in North America. METHODS: This is a retrospective review of ingestions of ibotenic acid and muscimol containing mushrooms reported to a United States regional poison center from 2002-2016...
August 3, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/30065066/peritoneal-infections-in-children-undergoing-acute-peritoneal-dialysis-at-a-tertiary-quaternary-central-hospital-in-kwazulu-natal-south-africa
#7
Mulalo Nepfumbada, Elaene Naicker, Rajendra Bhimma
BACKGROUND: In a resource-limited setting, acute peritoneal dialysis (APD) is the modality of choice as a form of renal replacement therapy in children with acute kidney injury (AKI). However, there is a high risk of peritonitis that causes significant morbidity and mortality. Data on PD and peritonitis in developing countries are scarce. The purpose of this retrospective study was to determine the prevalence of APD-related peritonitis at a central referral hospital in KwaZulu-Natal, South Africa...
July 31, 2018: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/30035208/assessment-of-a-renal-angina-index-for-prediction-of-severe-acute-kidney-injury-in-critically-ill-children-a-multicentre-multinational-prospective-observational-study
#8
Rajit K Basu, Ahmad Kaddourah, Stuart L Goldstein
Background: Acute kidney injury (AKI) occurs in one in four children admitted to the intensive care unit (ICU) and AKI severity is independently associated with increased patient morbidity and mortality. Early prediction of AKI has the potential to improve outcomes. In smaller, single center populations, we have previously derived and validated the performance of the renal angina index (RAI), a context driven risk stratification system, to predict severe AKI. Methods: A prospective, observational study (AWARE1 , January-December 2014) was conducted in intensive care units from 32 centers in 9 countries...
February 2018: Lancet Child & Adolescent Health
https://www.readbyqxmd.com/read/30028784/cardiac-surgery-associated-kidney-injury-in-children-and-renal-oximetry
#9
Rachel Joffe, Mohammed Al Aklabi, Sudeshna Bhattacharya, Dominic Cave, Thomas Calleja, Daniel Garros, Nicholas Majesic, Lindsay Ryerson, Catherine Morgan
OBJECTIVES: Cardiac surgery-associated acute kidney injury is common in children and associates with negative outcomes. Novel interventions to reduce cardiac surgery-associated acute kidney injury require knowledge of its pathophysiology. States of altered perfusion, oxygen delivery, and energy consumption occur during cardiopulmonary bypass and could protect against or contribute to renal cellular injury and recovery. Near-infrared spectroscopy is noninvasive technology for monitoring regional blood flow and tissue oxygenation...
July 19, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/30024573/major-adverse-events-following-over-shunting-are-associated-with-worse-outcomes-than-major-adverse-events-after-a-blocked-systemic-to-pulmonary-artery-shunt-procedure
#10
Kok Wai Soo, Johann Brink, Yves d'Udekem, Warwick Butt, Siva P Namachivayam
OBJECTIVES: Causes of major adverse event after systemic-to-pulmonary shunt procedure are usually shunt occlusion or over-shunting. Outcomes categorized on the basis of these causes will be helpful both for quality improvement and prognostication. DESIGN: Retrospective cohort analysis of children who underwent a systemic-to-pulmonary shunt after excluding those who had it for Norwood or Damus-Kaye-Stansel procedure. SETTING: The Royal Children's Hospital, Melbourne, VIC, Australia...
July 17, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/30022758/-predictive-value-of-red-blood-cell-distribution-width-for-acute-kidney-injury-in-children-with-sepsis
#11
Lin Zhang, Kuan-Peng Guo, Yi Mo, Su-Wu Yi, Cai-Zhi Huang, Cai-Xia Long, Li-Ya Mo
OBJECTIVE: To study the clinical value of red blood cell distribution width (RDW) in the early prediction of acute kidney injury (AKI) in children with sepsis. METHODS: A total of 126 children with sepsis were divided into an AKI group (n=66) and a non-AKI group (n=60) according to the presence or absence of AKI. These patients were also classified into high-RDW and low-RDW groups according to the mean RDW. The groups were compared in terms of age, male-to-female ratio, body mass index (BMI), Acute Physiology and Chronic Health Evaluation II (APACHE II) score, Sequential Organ Failure Assessment (SOFA) score, serum blood urea nitrogen (BUN), creatinine (Cr), uric acid (UA), serum C-reactive protein (CRP), and routine blood test results...
July 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/30022312/pre-operative-level-of-fgf23-predicts-severe-acute-kidney-injury-after-heart-surgery-in-children
#12
Oded Volovelsky, Tara C Terrell, Hayley Swain, Michael R Bennett, David S Cooper, Stuart L Goldstein
BACKGROUND: Early detection of acute kidney injury (AKI) after cardiac surgery has improved recently with the discovery and validation of novel urinary biomarkers. However, objective tools to predict the risk of AKI before the insult are still missing. We tested the hypothesis that pre-operative serum fibroblast growth factor 23 (FGF23) concentrations would be elevated in children who develop AKI after heart surgery with cardiopulmonary bypass (CPB). We also compared post-operative FGF23 concentrations to other biomarkers for early detection of AKI...
July 19, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/30001443/acute-kidney-injury-in-hospitalized-pediatric-patients
#13
Rajit K Basu
Acute kidney injury (AKI) is pervasive, affecting a significant proportion of critically ill and noncritically ill children. Recent data demonstrate a clear independent association of escalating AKI severity with not only mortality, but also with longer-term disability and chronic kidney disease in children. The paradigm has shifted-patients are no longer dying with AKI, but rather from AKI. In this review, AKI is described in the paradigms of "past," "present," and "future" to stimulate a reassessment of our understanding of this organ dysfunction syndrome...
July 1, 2018: Pediatric Annals
https://www.readbyqxmd.com/read/29992550/risk-factors-of-acute-kidney-injury-in-children-after-cardiac-surgery
#14
Ji-Hyun Lee, Ji-Yoon Jung, Sun-Woo Park, In-Kyung Song, Eun-Hee Kim, Hee-Soo Kim, Jin-Tae Kim
BACKGROUND: The objective of this retrospective study was to determine the risk factors for acute kidney injury (AKI), including albumin, in children who underwent cardiac surgery. In addition, we evaluated the association between preoperative serum albumin level and postoperative AKI in these patients. METHODS: This retrospective study included 505 pediatric patients who underwent congenital cardiac surgery. Preoperative and perioperative risk factors for AKI, including serum albumin level, were assessed...
July 11, 2018: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29988999/immunosuppressive-treatment-in-children-with-iga-nephropathy-and-the-clinical-value-of-podocytopathic-features
#15
Alexandra Cambier, Marion Rabant, Michel Peuchmaur, Alexandre Hertig, Georges Deschenes, Cecile Couchoud, Anne Kolko, Remi Salomon, Julien Hogan, Thomas Robert
Introduction: There is a need for treatment guidelines and prognostic factor identification in children with primary IgA nephropathy. We analyzed the causative effect of steroids and the applicability of the Oxford classification. Methods: A total of 82 consecutive children (mean 10.6 years; median follow-up 3.3 years) were reviewed; 21 patients (25.6%) presented with acute kidney injury, and 6 (7.3%) with nephrotic syndrome. Renal biopsies were scored for Oxford classification and podocytopathic features in 2 groups: a group treated with steroid therapy (some in association with cyclophosphamide) and supportive care (renin angiotensin system blockade) and a group treated by supportive care alone...
July 2018: KI Reports
https://www.readbyqxmd.com/read/29987455/nephrotoxin-exposure-and-acute-kidney-injury-in-critically-ill-children-undergoing-congenital-cardiac-surgery
#16
Amanda M Uber, Maria E Montez-Rath, David M Kwiatkowski, Catherine D Krawczeski, Scott M Sutherland
BACKGROUND: Though acute kidney injury (AKI) is often multifactorial, investigators are now emphasizing the specific contribution of nephrotoxins. This study examines the epidemiology of nephrotoxin exposure and nephrotoxin-associated AKI among children undergoing congenital heart surgery (CHS). METHODS: This is a retrospective cohort study of children admitted following CHS between June 1, 2014, and September 30, 2014. Nephrotoxins were defined according to the Nephrotoxic Injury Negated by Just-in-time-Action (NINJA) collaborative; high nephrotoxin exposure was defined as receipt of ≥ 3 nephrotoxins concurrently...
July 9, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29987453/utilization-of-the-renal-angina-index-in-picu-of-a-developing-country-for-prediction-of-subsequent-severe-acute-kidney-injury
#17
Raina Kaur, Gurdeep Singh Dhooria, Puneet A Pooni, Deepak Bhat, Siddharth Bhargava, Shruti Kakkar, Kamal Arora, Namita Bansal
BACKGROUND: Acute kidney injury (AKI) is independently associated with worsened morbidity and increased mortality in the pediatric intensive care unit (PICU). AKI risk score, termed renal angina index (RAI) is used in developed countries to predict subsequent severe AKI. Very few studies have investigated application of RAI in the PICU of a developing country. This prospective observational study aimed to predict severe subsequent AKI in children admitted to PICU using RAI. METHODS: Over 1 year, children admitted to PICU aged 1 month-18 years old, with no previous kidney disease, were included...
July 9, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29980292/acute-kidney-injury-complicating-nephrotic-syndrome-of-minimal-change-disease
#18
REVIEW
Alain Meyrier, Patrick Niaudet
Minimal change disease accounts for 70% to 90% of cases of nephrotic syndrome in children. It also causes nephrotic syndrome in adults, including patients older than age 60. Renal function is altered moderately in approximately 20% to 30% of patients because foot-process fusion impairs filtration of water and solutes. The glomerular filtration rate is reduced by approximately 20% to 30% and returns to baseline with remission of proteinuria. Over the past 50 years, a number of publications have reported cases of acute kidney injury occurring in approximately one-fifth to one-third of adult cases in the absence of prior or concomitant renal disease...
July 3, 2018: Kidney International
https://www.readbyqxmd.com/read/29972122/-association-of-hypoalbuminemia-with-acute-kidney-injury-in-children-after-cardiac-surgery
#19
Lian Duan, Guo-Huang Hu, Meng Jiang, Cheng-Liang Zhang, Yan-Ying Duan
OBJECTIVE: To study whether hypoalbuminemia after pediatric cardiopulmonary bypass (CPB) for cardiac surgery is a risk factor for postoperative acute kidney injury (AKI). METHODS: A retrospective analysis was performed on the clinical data of 1 110 children who underwent CPB surgery between 2012 and 2016. According to the minimum serum albumin within 48 hours postoperatively, these patients were divided into hypoalbuminemia group (≤35 g/L) and normal albumin group (>35 g/L)...
June 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29970747/pediatric-acute-kidney-injury-in-north-india-a-prospective-hospital-based-study
#20
Shariq Nawaz, Kamran Afzal
The conducted study aimed to determine the incidence and clinical profile of acute kidney injury (AKI) in hospitalized patients using the AKI Network (AKIN) criteria. This prospective observational study was conducted at the Pediatric ward and pediatric Intensive Care Unit of a tertiary level teaching hospital in North India. The participants were 763 consecutive patients aged three months to 12 years from January 2014 to October 2015 and were assessed for eligibility. Of these, 163 patients were excluded from the study...
May 2018: Saudi Journal of Kidney Diseases and Transplantation
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