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https://www.readbyqxmd.com/read/28231115/statistical-analysis-of-mineral-concentration-for-the-geographic-identification-of-garlic-samples-from-sicily-italy-tunisia-and-spain
#1
Rossella Vadalà, Antonio F Mottese, Giuseppe D Bua, Andrea Salvo, Domenico Mallamace, Carmelo Corsaro, Sebastiano Vasi, Salvatore V Giofrè, Maria Alfa, Nicola Cicero, Giacomo Dugo
We performed a statistical analysis of the concentration of mineral elements, by means of inductively coupled plasma mass spectrometry (ICP-MS), in different varieties of garlic from Spain, Tunisia, and Italy. Nubia Red Garlic (Sicily) is one of the most known Italian varieties that belongs to traditional Italian food products (P.A.T.) of the Ministry of Agriculture, Food, and Forestry. The obtained results suggest that the concentrations of the considered elements may serve as geographical indicators for the discrimination of the origin of the different samples...
March 15, 2016: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28230744/s-allylmercaptocysteine%C3%A2-attenuates%C3%A2-cisplatin-induced%C3%A2-nephrotoxicity%C3%A2-through%C3%A2-suppression%C3%A2-of%C3%A2-apoptosis-%C3%A2-oxidative%C3%A2-stress-%C3%A2-and%C3%A2-inflammation
#2
Xiaosong Zhu, Xiaoyan Jiang, Ang Li, Zhongxi Zhao, Siying Li
Cisplatin is a potent chemotherapeutic agent, but its clinical usage is limited by nephrotoxicity. S-allylmercaptocysteine (SAMC), one of the water-soluble organosulfur garlic derivatives, has antioxidant and anti-inflammatory properties and plays an important role in protecting cells from apoptosis. This study aims to examine the protective effects of SAMC on cisplatin nephrotoxicity and to explore the mechanism of its renoprotection. Rats were treated with cisplatin with or without pre-treatment with SAMC...
February 20, 2017: Nutrients
https://www.readbyqxmd.com/read/28224922/multiple-garlic-allium-sativum-l-micrornas-regulate-the-immunity-against-the-basal-rot-fungus-fusarium-oxysporum-f-sp-cepae
#3
Subodh Kumar Chand, Satyabrata Nanda, Rukmini Mishra, Raj Kumar Joshi
The basal plate rot fungus, Fusarium oxysporum f. sp. cepae (FOC), is the most devastating pathogen posing a serious threat to garlic (Allium sativum L.) production worldwide. MicroRNAs (miRNAs) are key modulators of gene expression related to development and defense responses in eukaryotes. However, the miRNA species associated with garlic immunity against FOC are yet to be explored. In the present study, a small RNA library developed from FOC infected resistant garlic line was sequenced to identify immune responsive miRNAs...
April 2017: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/28219971/predicting-human-olfactory-perception-from-chemical-features-of-odor-molecules
#4
Andreas Keller, Richard C Gerkin, Yuanfang Guan, Amit Dhurandhar, Gabor Turu, Bence Szalai, Joel D Mainland, Yusuke Ihara, Chung Wen Yu, Russ Wolfinger, Celine Vens, Leander Schietgat, Kurt De Grave, Raquel Norel, Gustavo Stolovitzky, Guillermo A Cecchi, Leslie B Vosshall, Pablo Meyer
It is still not possible to predict whether a given molecule will have a perceived odor or what olfactory percept it will produce. We therefore organized the crowd-sourced DREAM Olfaction Prediction Challenge. Using a large olfactory psychophysical data set, teams developed machine-learning algorithms to predict sensory attributes of molecules based on their chemoinformatic features. The resulting models accurately predicted odor intensity and pleasantness and also successfully predicted 8 among 19 rated semantic descriptors ("garlic," "fish," "sweet," "fruit," "burnt," "spices," "flower," and "sour")...
February 24, 2017: Science
https://www.readbyqxmd.com/read/28219698/protective-effects-of-diallyl-disulfide-against-acetaminophen-induced-nephrotoxicity-a-possible-role-of-cyp2e1-and-nf-%C3%AE%C2%BAb
#5
Je-Won Ko, Jin-Young Shin, Jeong-Won Kim, Sung-Hyeuk Park, Na-Rae Shin, In-Chul Lee, In-Sik Shin, Changjong Moon, Sung-Ho Kim, Sung-Hwan Kim, Jong-Choon Kim
Diallyl disulfide (DADS) is a degradation product of allicin which is contained in garlic. This study investigated the protective effects of DADS against acetaminophen (AAP)-induced nephrotoxicity and the molecular mechanisms of nephroprotective effects in rats. AAP caused severe nephrotoxicity as evidenced by significant increases in renal tubular cell apoptosis, mitochondria-mediated apoptosis, and up-regulation of nuclear transcription factor kappa-B (NF-κB), cyclooxygenase-2 (Cox-2), and tumor necrosis factor-α (TNF-α) in the kidney with histopathological alterations...
February 17, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28216882/anticancer-potential-of-nutraceutical-formulations-in-mnu-induced-mammary-cancer-in-sprague-dawley-rats
#6
Gummalla Pitchaiah, Annapurna Akula, Vishala Chandi
BACKGROUND: Nutraceuticals help in combating some of the major health problems of the century including cancer, and 'nutraceutical formulations' have led to the new era of medicine and health. OBJECTIVE: To develop different nutraceutical formulations and to assess the anticancer potential of nutraceutical formulations in N-methyl-N-nitrosourea (MNU)-induced mammary cancer in Sprague Dawley rats. MATERIALS AND METHODS: Different nutraceutical formulations were prepared using fine powders of amla, apple, garlic, onion, papaya, turmeric, and wheat grass with and without cow urine distillate...
January 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28216514/diallyl-trisulfide-augments-ischemia-induced-angiogenesis-via-an-endothelial-nitric-oxide-synthase-dependent-mechanism
#7
Ryo Hayashida, Kazuhisa Kondo, Sumio Morita, Kazumasa Unno, Satoshi Shintani, Yuuki Shimizu, John W Calvert, Rei Shibata, Toyoaki Murohara
BACKGROUND: Hydrogen sulfide (H2S) exerts beneficial actions against the development of cardiovascular disease. Diallyl trisulfide (DATS) is an organic polysulfide found in garlic oil that liberates H2S under physiological conditions. This study investigated whether DATS modulates endothelial cell function, as well as revascularization processes in a mouse model of hind-limb ischemia.Methods and Results:Wild-type (WT), endothelial nitric oxide synthase-deficient (eNOS-KO) and Akt1-heterogenic deficient (Akt-Het) mice were subjected to unilateral hindlimb ischemia (HLI)...
February 17, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28212297/inorganic-reactive-sulfur-nitrogen-species-intricate-release-mechanisms-or-cacophony-in-yellow-blue-and-red
#8
Marian Grman, Muhammad Jawad Nasim, Roman Leontiev, Anton Misak, Veronika Jakusova, Karol Ondrias, Claus Jacob
Since the heydays of Reactive Sulfur Species (RSS) research during the first decade of the Millennium, numerous sulfur species involved in cellular regulation and signalling have been discovered. Yet despite the general predominance of organic species in organisms, recent years have also seen the emergence of inorganic reactive sulfur species, ranging from inorganic polysulfides (HSx(-)/Sx(2-)) to thionitrous acid (HSNO) and nitrosopersulfide (SSNO(-)). These inorganic species engage in a complex interplay of reactions in vitro and possibly also in vivo...
February 15, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28209019/efficacy-of-specific-plant-products-on-microorganisms-causing-dental-caries
#9
M Rajini Kanth, A Ravi Prakash, G Sreenath, Vikram Simha Reddy, S Huldah
INTRODUCTION: Dental caries and periodontal diseases are the most common oral diseases seen globally, both in developed and developing countries. Oral microorganisms that is gram positive and gram negative bacteria are known to be involved in causation of these diseases. Nowadays commercially available dentrifices and mouth rinses are known to contain ingredients that can alter the oral microbial flora and have undesirable side effects such as vomiting, diarrhoea, disarrangement of oral, intestinal flora and tooth staining...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28206859/evaluation-and-adaptation-of-attractive-toxic-sugar-baits-for-culex-tarsalis-and-culex-quinquefasciatus-control-in-the-coachella-valley-southern-california
#10
Whitney A Qualls, Jodi Scott-Fiorenzano, Gunter C Müller, Kristopher L Arheart, John C Beier, Rui-De Xue
The project goal was to determine how a new vector control strategy that targets the sugar-feeding behavior of mosquitoes, attractive toxic sugar baits (ATSBs), can be used to more effectively control West Nile virus (WNV) vectors in the Coachella Valley, California. Three laboratory studies were conducted to determine the utility of this method for control against Culex quinquefasciatus and Culex tarsalis : 1) efficacy evaluations of 2 formulations of ATSB, microencapsulated garlic oil, and a combination of microencapsulated garlic oil and 1% boric acid; 2) choice assays to determine the attractiveness of ATSB with the microencapsulated garlic oil against attractive sugar baits (ASB; the attractant alone; without toxin) and a 10% sucrose solution; and 3) vegetation efficacy tests on 3 common plant species in the Coachella Valley, Atriplex lentiformis, Tamarix ramosissima , and Pluchea sericea...
December 2016: Journal of the American Mosquito Control Association
https://www.readbyqxmd.com/read/28205676/garlic-genomic-autozygosity-regions-likelihood-based-inference-and-classification
#11
Zachary A Szpiech, Alexandra Blant, Trevor J Pemberton
No abstract text is available yet for this article.
February 16, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28197933/garlic-extract-attenuates-immobilization-stress-induced-alterations-in-plasma-antioxidant-oxidant-parameters-and-hepatic-function-in-rats
#12
Syed Kashif Zaidi, Shakeel Ahmed Ansari, Shams Tabrez, Md Nasrul Hoda, Ghulam Md Ashraf, Mohd Shahnawaz Khan, Sultan Alnohair, Naheed Banu, Mohammed Hussain Al-Qahtani
OBJECTIVE: To investigate the oxidative stress induced by 6 h of immobilization stress in Albino Wistar rats. Further, the pre- and post-treatment of aqueous garlic extract was studied to evaluate its preventive and curative efficacy on stress-induced altered oxidative parameters in rats. METHODS: Albino Wistar rats were exposed to 6 h of immobilization stress, and received garlic extract (100 mg/kg body weight) treatment pre- or post-stress exposure. The oxidative status of plasma after various treatments were evaluated by determining the levels of reduced glutathione, glucose, uric acid, thiobarbituric acid reactive substances, aspartate aminotransferase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) and the activities of superoxide dismutase, catalase and glutathione-S-transferase by standardized procedures...
February 15, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28197857/diallyl-disulfide-suppresses-the-inflammation-and-apoptosis-resistance-induced-by-dca-through-ros-and-the-nf-%C3%AE%C2%BAb-signaling-pathway-in-human-barrett-s-epithelial-cells
#13
Cheng Feng, Yumei Luo, Yuanyuan Nian, Dong Liu, Xiaoran Yin, Jing Wu, Jia Di, Rong Zhang, Jun Zhang
Barrett's esophagus (BE) is generally accepted as the only precursor to esophageal adenocarcinoma (EAC). Deoxycholic acid (DCA)-induced inflammation and apoptotic resistance play an important role in the carcinogenesis and progression from BE to EAC. Diallyl disulfide (DADS) is a garlic-derived natural organosulfur compound. This study investigated whether DADS has chemopreventive effects against BE and the potentially related signaling pathway. BAR-T cells were treated with DCA in the presence or absence of DADS...
February 14, 2017: Inflammation
https://www.readbyqxmd.com/read/28196294/comparison-of-immunomodulatory-effects-of-fresh-garlic-and-black-garlic-polysaccharides-on-raw-264-7-macrophages
#14
Min Li, Yi-Xi Yan, Qing-Tao Yu, Yong Deng, Ding-Tao Wu, Ying Wang, Ya-Zhong Ge, Shao-Ping Li, Jing Zhao
Garlic has a long history to be used for medicine and food purposes. Black garlic, the fermented product of fresh garlic, is considered with better biological activities, such as antioxidant activity, and is developed as an increasingly popular functional food. Polysaccharides are the major components of fresh and black garlic, and immunomodulatory activity is one major pharmacological effect of polysaccharides. Therefore, chemical characteristics and immunomodulatory effects of polysaccharides from fresh and black garlic are investigated and compared in vitro for the 1st time, in order to reveal their molecular and pharmacological differences...
February 14, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28195548/herbal-approach-in-the-treatment-of-pancytopenia
#15
Siddhi Manohar Bagwe, Pravin Popatrao Kale, Lokesh Kumar Bhatt, Kedar S Prabhavalkar
Pancytopenia is a health condition in which there is a reduction in the amount of leucocytes, erythrocytes and thrombocytes. If more than one of the blood cells is low then the condition is called as bicytopenia. The pancytopenic condition is observed in treatment of diseased conditions like thalassemia and hepatitis C. Iatrogenically pancytopenia is caused by some antibiotics and anti-HCV drugs. Medical conditions like aplastic anaemia, lymphoma, copper deficiency, and so forth can also cause pancytopenia...
February 14, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/28194108/novel-sulfur-metabolites-of-garlic-attenuate-cardiac-hypertrophy-and-remodeling-through-induction-of-na-k-atpase-expression
#16
Tarak N Khatua, Roshan M Borkar, Soheb A Mohammed, Amit K Dinda, R Srinivas, Sanjay K Banerjee
Epidemiologic studies show an inverse correlation between garlic consumption and progression of cardiovascular disease. However, the molecular basis for the beneficial effect of garlic on the heart is not known. Therefore, the objective of the present study was to (1) investigate the effect of raw garlic on isoproterenol (Iso) induced cardiac hypertrophy (2) find the active metabolites of garlic responsible for the beneficial effect. Cardiac hypertrophy was induced in rats by subcutaneous single injection of Iso 5 mg kg(-1) day(-1) for 15 days and the effect of garlic (250 mg/kg/day orally) was evaluated...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28191330/does-garlic-supplementation-control-blood-pressure-in-patients-with-severe-coronary-artery-disease-a-clinical-trial-study
#17
Marjan Mahdavi-Roshan, Javad Nasrollahzadeh, Ali Mohammad Zadeh, Ali Zahedmehr
BACKGROUND: Hypertension is one of the major risk factors for cardiovascular morbidities, including coronary artery disease (CAD). OBJECTIVES: With interest on the important role of hypertension in the progression of CAD, this study was designed to estimate the effect of garlic powder tablets on the blood pressure (BP) in patients with severe CAD. METHODS: A randomized, placebo-controlled, clinical trial was conducted on 56 CAD patients, aged 25 - 75 years old...
November 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/28188296/effect-of-garlic-gingko-and-st-john-s-wort-extracts-on-the-pharmacokinetics-of-fexofenadine-a-mechanistic-study
#18
Jasmina Turkanovic, Jacobus P Gerber, Michael B Ward, Robert W Milne
The aim of this study was to determine the effects of garlic and ginkgo herbal extracts on the pharmacokinetics of the P-glycoprotein (P-gp)/Organic anion transporting polypeptides (Oatps) substrate fexofenadine. Male rats were dosed orally with garlic (120 mg/kg), ginkgo (17 mg/kg), St. John's wort (SJW; 1000 mg/kg; positive control) or milli Q water for 14 days. On day 15, rats were either administered fexofenadine (orally or intravenously), had their livers isolated and perfused with fexofenadine, or the small intestine divided into four segments (SI-SIV) and analysed for P-gp and Oatp1a5...
February 10, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28187175/hspa6-augments-garlic-extract-induced-inhibition-of-proliferation-migration-and-invasion-of-bladder-cancer-ej-cells-implication-for-cell-cycle-dysregulation-signaling-pathway-alteration-and-transcription-factor-associated-mmp-9-regulation
#19
Seung-Shick Shin, Jun-Hui Song, Byungdoo Hwang, Dae-Hwa Noh, Sung Lyea Park, Won Tae Kim, Sung-Soo Park, Wun-Jae Kim, Sung-Kwon Moon
Although recent studies have demonstrated the anti-tumor effects of garlic extract (GE), the exact molecular mechanism is still unclear. In this study, we investigated the molecular mechanism associated with the inhibitory action of GE against bladder cancer EJ cell responses. Treatment with GE significantly inhibited proliferation of EJ cells dose-dependently through G2/M-phase cell cycle arrest. This G2/M-phase cell cycle arrest by GE was due to the activation of ATM and CHK2, which appears to inhibit phosphorylation of Cdc25C (Ser216) and Cdc2 (Thr14/Tyr15), this in turn was accompanied by down-regulation of cyclin B1 and up-regulation of p21WAF1...
2017: PloS One
https://www.readbyqxmd.com/read/28183044/metabolomic-study-on-the-antihypertensive-effect-of-s-1-propenylcysteine-in-spontaneously-hypertensive-rats-using-liquid-chromatography-coupled-with-quadrupole-orbitrap-mass-spectrometry
#20
Toshiaki Matsutomo, Mitsuyasu Ushijima, Yukihiro Kodera, Masashi Nakamoto, Miyuki Takashima, Naoaki Morihara, Koichi Tamura
Aged garlic extract (AGE) has been shown to improve hypertension in both clinical trials and experimental animal models. However, the active ingredient of AGE remains unknown. In the present study, we investigated the antihypertensive effects of AGE and its major constituents including S-1-propenylcysteine (S1PC) and S-allylcysteine (SAC) using spontaneously hypertensive rats (SHR) and found that S1PC is an active substance to lower blood pressure in SHR. In addition, the metabolomics approach was used to investigate the potential mechanism of the antihypertensive action of S1PC in SHR...
January 30, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
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