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https://www.readbyqxmd.com/read/29331459/garlic-allium-sativum-l-fed-to-dairy-cows-does-not-modify-the-cheese-making-properties-of-milk-but-affects-the-color-texture-and-flavor-of-ripened-cheese
#1
Giulia Rossi, Stefano Schiavon, Giovanna Lomolino, Claudio Cipolat-Gotet, Alberto Simonetto, Giovanni Bittante, Franco Tagliapietra
Garlic and garlic components have recently been proposed as ruminal activity modulators to reduce the enteric methane emissions of ruminants, but little is known of their influence on milk coagulation properties, nutrient recovery, cheese yield, and sensorial and rheological characteristics of milk and cheese. The present study assessed the effects of garlic and diallyl sulfide supplements on dry matter intake (DMI), productive performance, milk coagulation properties, cheese yield, milk and cheese sensory profiles, and rheological characteristics...
January 10, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29329251/pharmacological-investigation-of-the-anti-inflammation-and-anti-oxidation-activities-of-diallyl-disulfide-in-a-rat-emphysema-model-induced-by-cigarette-smoke-extract
#2
Yan Liu, Ang Li, Xiuli Feng, Xiao Sun, Xiaosong Zhu, Zhongxi Zhao
Diallyl disulfide (DADS) is the main organosulfur ingredient in garlic, with known antioxidant and anti-inflammatory activities. The aim of the present study was to investigate the effect of DADS on reducing the inflammation and redox imbalance in a rat emphysema model that was induced by intraperitoneal injection of cigarette smoke extract (CSE). Briefly, DADS exerted an anti-inflammation effect on emphysema rats through decreasing cell influx in the bronchoalveolar lavage fluid (BALF) and suppressing pro-inflammation cytokine production including tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6) via inhibiting the NF-κB pathway...
January 12, 2018: Nutrients
https://www.readbyqxmd.com/read/29318305/geographical-origin-characterization-of-slovenian-organic-garlic-using-stable-isotope-and-elemental-composition-analyses
#3
Anja Mahne Opatić, Marijan Nečemer, David Kocman, Sonja Lojen
In the present research, the applicability of stable isotope (δ13C, δ15N, δ34S, δ18O) and multi-element (P, S, Cl, K, Ca, Zn, Br, Rb, Sr) data for determining the geographical origin of garlic (Allium sativum L.) at the scale of Slovenia was examined. Slovenia is a rather small country (20273 km2) with significant geological and biological diversity. Garlic, valued for its medicinal properties, was collected from Slovenian farms with certified organic production and analyzed by elemental analyzer isotope ratio mass spectrometry combined with energy dispersive X- ray fluorescence spectrometry...
December 2017: Acta Chimica Slovenica
https://www.readbyqxmd.com/read/29305303/alliin-attenuates-1-3-dichloro-2-propanol-induced-lipogenesis-in-hepg2-cells-through-activation-of-the-amp-activated-protein-kinase-dependent-pathway
#4
Jing Lu, Bijun Cheng, Zhuoqun Meng, Baochen Fang, Tianjiao Li, Maocheng Sun, Meitong Liu, Shuang Guan
Accumulating evidence reveals the association of 1, 3-dichloro-2-propanol (1, 3-DCP) exposure and lipogenesis. Alliin, the most abundant sulphur compound in garlic, has been demonstrated to exhibit hypoglycemic, antioxidant and anti-inflammatory activities. Here, we showed that alliin attenuated lipogenesis induced by 1,3-DCP and that the reduction was due to activation of the AMPK pathway. HepG2 cells exposed to 1,3-DCP exhibited significant increase of triglyceride(TG) and total cholesterol(TC), and alliin reduced the accumulation...
January 2, 2018: Life Sciences
https://www.readbyqxmd.com/read/29288771/s-allyl-cysteine-regulates-the-tnf%C3%AE-induced-muscle-wasting-by-suppressing-proteolysis-and-regulating-the-inflammatory-molecules-in-skeletal-muscle-myotubes
#5
Vikas Dutt, Vikram Saini, Prachi Gupta, Nirmaljeet Kaur, Manju Bala, Ravindra Gujar, Anita Grewal, Sanjeev Gupta, Anita Dua, Ashwani Mittal
BACKGROUND: Elevated levels of inflammatory molecules are the key players in muscle wasting/atrophy leading to human morbidity. TNFα is a well-known pro-inflammatory cytokine implicated in the pathogenesis of muscle wasting under diverse clinical settings. S-allyl cysteine (SAC), an active component of garlic (Allium sativum), has established anti-oxidant and anti-inflammatory effects in various cell types. However, the impact of SAC on skeletal muscle pathology remains unexplored. Owing to the known anti-inflammatory properties of SAC, we investigate whether pre-treatment with SAC has a protective role in TNFα induced atrophy in cultured myotubes...
December 27, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29287429/antimicrobial-and-antioxidant-properties-of-various-greek-garlic-genotypes
#6
Spyridon Petropoulos, Ângela Fernandes, Lillian Barros, Ana Ciric, Marina Sokovic, Isabel C F R Ferreira
Recent studies show a significant variation in antioxidant and antimicrobial properties between the various garlic genotypes mostly due to differences in chemical composition and bioactive compounds content. The aim of the present study was to evaluate antioxidant properties and antimicrobial activity of garlics collected from the main cultivation areas of Greece, as well as to correlate this activity with their total phenolics content. Genotype G5 showed the highest total phenolics content, which was significantly correlated with the lowest EC50 values for all the tested antioxidant activity assays...
April 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29280389/the-effects-of-black-garlic-on-the-working-memory-and-pyramidal-cell-number-of-medial-prefrontal-cortex-of-rats-exposed-to-monosodium-glutamate
#7
Titis Nurmasitoh, Dwi Cahyani Ratna Sari, Ginus Partadiredja
Monosodium glutamate-induced exitotoxicity causes oxidative stress in many brain areas, including the medial prefrontal cortex. The ethanolic garlic (Allium sativum) extract is considered as a neuroprotective substance. The present study aimed at investigating the effects of the ethanolic fermented garlic extract on the working memory and the pyramidal cell number of the medial prefrontal cortex of adolescent male Wistar rats exposed to monosodium glutamate (MSG). Twenty-five rats were randomly divided into five groups...
December 27, 2017: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/29251532/metabolism-and-pharmacokinetics-studies-of-allyl-methyl-disulfide-in-rats
#8
Yan Liu, Ang Li, Xiaoyan Jiang, Xiaosong Zhu, Xiuli Feng, Xiao Sun, Zhongxi Zhao
1. Allyl methyl disulfide (AMDS) is one of the main compounds in garlic whereas its metabolism has not been studied yet. 2. In this work, we first identified the metabolites of AMDS in rat erythrocytes and rats using GC-MS. The transformation mechanism study among different metabolites was then conducted. The apparent kinetics of AMDS in rat erythrocytes and pharmacokinetics of AMDS by oral administration in rats were also studied. 3. The metabolic pathway study showed that AMDS were mainly metabolized in rats to allyl methyl sulfoxide (AMSO) and allyl methyl sulfone (AMSO2) through mechanisms of reduction, methylation and oxidation...
December 18, 2017: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/29248015/plant-extracts-as-a-natural-treatment-against-the-fish-ectoparasite-neobenedenia-sp-monogenea-capsalidae
#9
A G Trasviña-Moreno, F Ascencio, C Angulo, K S Hutson, A Avilés-Quevedo, R B Inohuye-Rivera, J C Pérez-Urbiola
The toxicity of water-ethanol extracts of garlic (Allium sativum), ginger (Zingiber officinale), basil (Ocimum basilicum), bitter chaparro (Castela tortuousa), onion (Allium cepa) and papaya (Carica papaya) against adults, eggs and oncomiracidia of Neobenedenia spp. parasites was examined. Parasites were exposed to continuous immersion and treated as follows: extracts were tested at three dilutions: 1:10, 1:50 and 1:100 made with filtered seawater (35 g l-1); ethanol (70%) was evaluated at the same dilutions of 1:10 (7% ethanol), 1:50 (1...
December 17, 2017: Journal of Helminthology
https://www.readbyqxmd.com/read/29243835/diallyl-trisulfide-inhibits-breast-cancer-stem-cells-via-suppression-of-wnt-%C3%AE-catenin-pathway
#10
Xiaoting Li, Yu Meng, Chunfeng Xie, Jianyun Zhu, Xiaoqian Wang, Yuan Li, Shanshan Geng, Jieshu Wu, Caiyun Zhong, Min Li
Cancer stem cells (CSCs) play a central role in the development of breast cancer. The canonical Wnt/β-catenin signal pathway is critical for maintaining CSCs characteristics. Diallyl trisulfide (DATS), a natural organosulfur compound from the garlic, exhibits effective antitumor properties. However, the role of DATS in regulating breast CSCs activity and the underlying molecular mechanisms remain obscure. In the present study, we reported that DATS efficiently inhibited the viability of breast CSCs as evidenced by reducing turmorspheres formation, decreasing the expression of breast CSCs markers (CD44, ALDH1A1, Nanog and Oct4), as well as inhibiting proliferation and inducing apoptosis...
December 15, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29239661/enhancement-of-the-antimycobacterial-activity-of-macrophages-by-ajoene
#11
Ji-Ae Choi, Soo-Na Cho, Yun-Ji Lim, Junghwan Lee, Dam Go, Seon-Hwa Kim, Chang-Hwa Song
Ajoene, a garlic-derived sulfur-containing compound, has broad-spectrum antimicrobial activity. To assess the potential of ajoene for treating tuberculosis (TB), we determined whether it induces the stress response of the endoplasmic reticulum (ER), which plays an important role in TB. We showed that ajoene stimulation induced the production of ER stress sensor molecules and reactive oxygen species (ROS) levels. Ajoene-induced ROS production was dependent on c-Jun N-terminal kinase (JNK) activation. Interestingly, the inhibition of JNK activity and suppression of ROS production reduced ajoene-induced CHOP production in macrophages...
January 1, 2017: Innate Immunity
https://www.readbyqxmd.com/read/29215100/quillaja-saponin-based-hollow-salt-particles-as-solid-carriers-for-enhancing-sensory-aroma-with-reduced-sodium-intake
#12
Xiao-Wei Chen, Dan-Xia Yang, Jian Guo, Qi-Jun Ruan, Xiao-Quan Yang
Dietary salt is a vital ingredient associated with sensory performance in processed foods, while reduced salt intake linked to public health is highly desired by consumers and food manufacturers. In this paper, quillaja saponin (QS) based hollow salt particles (∼10 μm) were fabricated by simple spray drying, and utilized as solid carriers to enhance sensory aromas with reduced sodium intake. QS-coated nanodroplets were firstly prepared as a reservoir for flavor oils (lemon and garlic oil), and then served as frameworks to construct hollow salt particles via general spray drying...
December 7, 2017: Food & Function
https://www.readbyqxmd.com/read/29208504/hepatoprotective-effects-of-garlic-against-ethanol-induced-liver-injury-a-mini-review
#13
REVIEW
Min-Jie Guan, Ning Zhao, Ke-Qin Xie, Tao Zeng
Alcoholic liver disease (ALD) is a progressively aggravated liver disease with a diverse spectrum from steatosis to hepatitis, fibrosis, and cirrhosis. Epidemiological studies reveal that alcohol is one of the major causes of advanced liver disease in Europe, United States, and China. Despite the considerable harm, progression in ALD research is slow and the current therapies for ALD have less efficient. Garlic (Allium sativum) has been used as a flavoring agent and also a folk medicine since ancient time. Along with the prosperity in the use of herbal medicines for the treatment of human diseases in recent decades, a series of studies have focused on the beneficial effects of garlic against ALD...
December 2, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29207122/diallyl-disulfide-inhibits-the-metastasis-of-type-%C3%A2-esophageal%C3%A2-gastric-junction-adenocarcinoma-cells-via-nf-%C3%AE%C2%BAb-and-pi3k-akt-signaling-pathways-in-vitro
#14
Xiaoran Yin, Cheng Feng, Lili Han, Yinan Ma, Yang Jiao, Jun Wang, Lijun Jia, Fuchun Jing, Xiaoyan Gao, Yinbin Zhang, Jun Zhang
Esophageal-gastric junction adenocarcinoma (AEG) is an aggressive tumor with high incidence and dismal prognosis worldwide. Despite significant advances in therapeutic strategies, the 5-year survival rate still remains low. Diallyl disulfide (DADS), which is one of the major volatile components isolated from garlic, has been shown to have multi-targeted antitumor activities in a variety of cancer cells. However, the exact anti-metastatic effects and underlying molecular mechanisms of DADS in AEG have not been elucidated...
November 27, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29202189/effects-of-pesticides-on-the-survival-of-rove-beetle-coleoptera-staphylinidae-and-insidious-flower-bug-hemiptera-anthocoridae-adults
#15
Raymond A Cloyd, Nathan J Herrick
This study determined the direct, indirect, or both effects of pesticides on the rove beetle, Dalotia coriaria (Kraatz) (Coleoptera: Staphylinidae), and the insidious flower bug, Orius insidiosus (Say) (Hemiptera: Anthocoridae). The pesticides evaluated were Capsicum oleoresin extract, garlic oil, and soybean oil; cyantraniliprole; flupyradifurone; GS-omega/kappa-Hxtx-Hv1; Isaria fumosorosea; tolfenpyrad; pyrethrins; and spinosad. One experiment was conducted in a greenhouse with rove beetle adults exposed to growing medium applications of cyantraniliprole...
November 30, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29201054/antibacterial-effects-of-natural-herbal-extracts-on-streptococcus-mutans-can-they-be-potential-additives-in-dentifrices
#16
Spoorthi Banavar Ravi, Sudarshini Nirupad, Prashanthi Chippagiri, Rohit Pandurangappa
Background: Many plants or herbs exhibit potent antimicrobial activity against various microorganisms. They have no side effects and presumably act against and modulate the factors that are crucial for microbial survival or their activity. Streptococcus mutans is a pioneer bacteria implicated in dental caries. This study aims to evaluate the antimicrobial activity of garlic bulbs, pudina leaves, and mango and eucalyptus twig extracts on Streptococcus mutans by evaluating their zone of inhibition and determining their minimum inhibitory concentration (MIC)...
2017: International Journal of Dentistry
https://www.readbyqxmd.com/read/29196903/concurrent-use-of-prescription-drugs-and-herbal-medicinal-products-in-older-adults-a-systematic-review
#17
REVIEW
Taofikat B Agbabiaka, Barbara Wider, Leala K Watson, Claire Goodman
BACKGROUND: The use of herbal medicinal products (HMPs) is common among older adults; however, little is known about concurrent use with prescription drugs, as well as potential interactions associated with such combinations. OBJECTIVE: The aim of this systematic review was to identify and evaluate the literature on concurrent prescription and HMP use among older adults to assess prevalence, patterns, potential interactions and factors associated with this use. METHODS: Systematic searches were conducted in the MEDLINE, PsycINFO, EMBASE, CINAHL, AMED, Web of Science and Cochrane databases from inception to May 2017 for studies reporting concurrent use of prescription medicines with HMPs in adults ≥ 65 years of age...
December 1, 2017: Drugs & Aging
https://www.readbyqxmd.com/read/29196013/the-potential-of-herbs-and-spices-to-reduce-lipid-oxidation-during-heating-and-gastrointestinal-digestion-of-a-beef-product
#18
T Van Hecke, P L Ho, S Goethals, S De Smet
Here we tested the potential of ten culinary herbs (basil, oregano, rosemary and thyme) and spices (black pepper, cayenne pepper, cumin, curcuma, garlic and sweet paprika) to limit oxidation during cooking of a high-fat beef product, and during its subsequent in vitro gastrointestinal digestion. The herbs and spices were added separately at 0.5% and 1% (w/w), either during meat processing before heating of the product or after heating of the meat as a seasoning. Lipid oxidation was evaluated by malondialdehyde, 4-hydroxy-2-nonenal and hexanal quantification in the meat products and gastrointestinal digests...
December 2017: Food Research International
https://www.readbyqxmd.com/read/29182588/fluorinated-analog-nmr-s-of-organosulfur-compounds-from-garlic-allium-sativum-synthesis-chemistry-and-anti-angiogenesis-and-antithrombotic-studies
#19
Eric Block, Benjamin Bechand, Sivaji Gundala, Abith Vattekkatte, Kai Wang, Shaymaa S Mousa, Kavitha Godugu, Murat Yalcin, Shaker A Mousa
We describe the synthesis, reactivity, and antithrombotic and anti-angiogenesis activity of difluoroallicin (S-(2-fluoroallyl) 2-fluoroprop-2-ene-1-sulfinothioate) and S-2-fluoro-2-propenyl-l-cysteine, both easily prepared from commercially available 3-chloro-2-fluoroprop-1-ene, as well as the synthesis of 1,2-bis(2-fluoroallyl)disulfane, 5-fluoro-3-(1-fluorovinyl)-3,4-dihydro-1,2-dithiin, trifluoroajoene ((E,Z)-1-(2-fluoro-3-((2-fluoroallyl)sulfinyl)prop-1-en-1-yl)-2-(2-fluoroallyl)disulfane), and a bis(2-fluoroallyl)polysulfane mixture...
November 28, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29181754/formulation-and-characterization-of-garlic-allium-sativum-l-essential-oil-nanoemulsion-and-its-acaricidal-activity-on-eriophyid-olive-mites-acari-eriophyidae
#20
Abdel-Tawab H Mossa, Sahar I Afia, Samia M M Mohafrash, Badawi A Abou-Awad
Green and nanoacaricides including essential oil (EO) nanoemulsions are important compounds to provide new, active, safe acaricides and lead to improvement of avoiding the risk of synthetic acaricides. This study was carried out for the first time on eriophyid mites to develop nanoemulsion of garlic essential oil by ultrasonic emulsification and evaluate its acaricidal activity against the two eriophyid olive mites Aceria oleae Nalepa and Tegolophus hassani (Keifer). Acute toxicity of nanoemulsion was also studied on male rats...
November 27, 2017: Environmental Science and Pollution Research International
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