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https://www.readbyqxmd.com/read/29159686/new-cyclic-sulfides-extracted-from-allium-sativum-garlicnins-p-j2-and-q
#1
Toshihiro Nohara, Masateru Ono, Naho Nishioka, Fuka Masuda, Yukio Fujiwara, Tsuyoshi Ikeda, Daisuke Nakano, Junei Kinjo
Two atypical cyclic-type sulfides, garlicnin P (1) and garlicnin J2 (2), and one thiabicyclic-type sulfide, garlicnin Q (3), were isolated from the acetone extracts of garlic, Allium sativum, bulbs cultivated in the Kumamoto city area, and their structures characterized. Their production pathways are also discussed.
November 20, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/29154059/traditional-herbal-medicine-use-among-people-living-with-hiv-aids-in-gondar-ethiopia-do-their-health-care-providers-know
#2
Kaleab Taye Haile, Asnakew Achaw Ayele, Abebe Basazn Mekuria, Chilot Abiyu Demeke, Begashaw Melaku Gebresillassie, Daniel Asfaw Erku
BACKGROUND: People living with HIV/AIDS (PLWHA) are increasingly using herbal remedies due to the chronic nature of the disease, the complexities of treatment modalities and the difficulty in adhering to the therapeutic regimens. Yet, research on herbal medicine use in this patient population is scarce in Ethiopia. The present study aimed at investigating the prevalence and factors associated with the use of traditional herbal medicine among PLWHA in Gondar, Ethiopia. METHODS: A cross sectional survey was conducted on 360 PLWHA attending the outpatient clinic of University of Gondar referral and teaching hospital from September 1 to 30, 2016...
December 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/29150558/branched-pectic-galactan-in-phloem-sieve-element-cell-walls-implications-for-cell-mechanics
#3
Thomas A Torode, Rachel E O'Neill, Susan E Marcus, Valerie Cornuault, Sara Pose-Albacete, Rebecca P Lauder, Stjepan Kresimir Kracun, Maja Gro Rydahl, Mathias C F Andersen, William George Tycho Willats, Siobhan Ariel Braybrook, Belinda J Townsend, Mads H Clausen, J Paul Knox
A major question in plant biology concerns the specification and functional differentiation of cell types. This is in the context of constraints imposed by networks of cell walls that both adhere cells and contribute to the form and function of developing organs. Here, we report the identification of a glycan epitope that is specific to phloem sieve element cell walls in several systems. A monoclonal antibody, designated LM26, binds to the cell wall of phloem sieve elements in stems of Arabidopsis thaliana, Miscanthus x giganteus and notably sugar beet (Beta vulgaris) roots where phloem identification is an important factor for the study of phloem unloading of sucrose...
November 17, 2017: Plant Physiology
https://www.readbyqxmd.com/read/29140808/randomized-trial-evaluating-the-effect-of-aged-garlic-extract-with-supplements-versus-placebo-on-adipose-tissue-surrogates-for-coronary-atherosclerosis-progression
#4
Irfan Zeb, Naser Ahmadi, Ferdinand Flores, Matthew J Budoff
AIMS: Increased epicardial adipose tissue (EAT), pericardial adipose tissue (PAT), periaortic adipose tissue (PaAT), and subcutaneous adipose tissue (SAT) are mediators of metabolic risk, and are associated with the severity of coronary artery calcium (CAC). Aged garlic extract (AGE) has been shown to reduce the progression of coronary atherosclerosis. This study evaluates the effect of AGE with supplements (AGE+S) on EAT, PAT, SAT, and PaAT. METHODS: Sixty asymptomatic participants participated in a randomized trial evaluating the effect of AGE+S versus placebo on coronary atherosclerosis progression, and underwent CAC at baseline and after 12 months of treatment...
November 14, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/29126733/allicin-inspired-pyridyl-disulfides-as-antimicrobial-agents-for-multidrug-resistant-staphylococcus-aureus
#5
Jordan G Sheppard, Jeremy P McAleer, Pushkar Saralkar, Werner J Geldenhuys, Timothy E Long
A chemical library comprised of nineteen synthesized pyridyl disulfides that emulate the chemical reactivity of allicin (garlic) was evaluated for antimicrobial activity against a panel of pathogenic bacteria. Gram-positive species including vancomycin-intermediate and vancomycin-resistant Staphylococcus aureus (VISA, VRSA) demonstrated the highest level of susceptibility toward analogs with S-alkyl chains of 7-9 carbons in length. Further biological studies revealed that the disulfides display synergy with vancomycin against VRSA, cause dispersal of S...
October 12, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29121704/development-and-metabolite-profiling-of-elephant-garlic-vinegar
#6
Jeong-Won Kim, Deokyeol Jeong, Youngsuk Lee, Dongyup Han, Ju-Ock Nam, Won-Young Lee, Dong-Hyuck Hong, Soo Rin Kim, Yu Shin Ha
Elephant garlic (Allium ampeloprasum var. ampeloprasum), which belongs to the Alliaceae family along with onion and garlic, has a flavor and shape similar to those of normal garlic, but is not true garlic. Additionally, its properties are largely unknown, and its processing and product development have not been reported. In this study, we focused on using elephant garlic to produce a new type of vinegar, for which the market is rapidly growing because of its health benefits. First, we evaluated the effects of elephant garlic addition on acetic acid fermentation of rice wine by Acetobacter pasteurianus...
November 9, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29113106/headspace-solid-phase-microextraction-and-ultrasonic-extraction-with-the-solvent-sequences-in-chemical-profiling-of-allium-ursinum-l-honey
#7
Igor Jerković, Piotr M Kuś
A volatile profile of ramson (wild garlic, Allium ursinum L.) honey was investigated by headspace solid-phase microextraction (HS-SPME) and ultrasonic solvent extraction (USE) followed by gas chromatography and mass spectrometry (GC-FID/GC-MS) analyses. The headspace was dominated by linalool derivatives: cis- and trans-linalool oxides (25.3%; 9.2%), hotrienol (12.7%), and linalool (5.8%). Besides direct extraction with dichloromethane and pentane/diethyl ether mixture (1:2, v/v), two solvent sequences (I: pentane → diethyl ether; II: pentane → pentane/diethyl ether (1:2, v/v) → dichloromethane) were applied...
November 6, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29111889/the-combined-effects-of-exercise-diet-and-a-multi-ingredient-dietary-supplement-on-body-composition-and-adipokine-changes-in-overweight-adults
#8
Shawn M Arent, Alan J Walker, Joseph K Pellegrino, David J Sanders, Bridget A McFadden, Tim N Ziegenfuss, Hector L Lopez
BACKGROUND: Very few weight and fat loss supplements undergo finished-product research to examine efficacy. The purpose of this study was to determine the effects of an 8-week diet and exercise program on body composition, hip and waist girth, and adipokines and evaluate whether a dietary supplement containing raspberry ketone, capsaicin, caffeine, garlic, and Citrus aurantium enhanced outcomes. METHODS: Overweight men and women completed this randomized, placebo-controlled, double-blind study...
November 7, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/29111753/biogenic-nanostructured-porous-silicon-as-a-carrier-for-stabilization-and-delivery-of-natural-therapeutic-species
#9
Nguyen T Le, Jhansi R Kalluri, Armando Loni, Leigh T Canham, Jeffery L Coffer
Nanostructured mesoporous silicon (pSi) derived from the silicon-accumulator plant Tabasheer (Bambuseae) is demonstrated to serve as a potential carrier matrix for carrying and stabilizing naturally active, but otherwise metastable, therapeutic agents. Particularly, in this study, garlic oil containing phytochemicals (namely, allicin) that are capable of inhibiting Staphylococcus aureus (S. aureus) bacterial growth were incorporated into Tabasheer-derived porous silicon. Thermogravimetric analysis (TGA) indicated that relatively high amounts of the extract (53...
November 13, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29109311/antimicrobial-effect-of-ginger-garlic-honey-and-lemon-extracts-on-streptococcus-mutans
#10
Kiran Mathai, Swathy Anand, A Aravind, Praveen Dinatius, Anandhu V Krishnan, Meera Mathai
AIM: The aim of this study was to evaluate the effect of lemon, ginger, garlic, and honey extracts on Streptococcus mutans. MATERIALS AND METHODS: Commercially obtained honey, ginger, garlic, and lemon were included in the study to evaluate its efficacy in isolation and in combination against S. mutans. The efficacies of extracts were tested using well diffusion method, and its effect was evaluated by measuring the zone of inhibition around the well. Antimicrobial activity of the extracts was carried out individually and compared considering triplicates of all the extracts...
November 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/29108412/allium-discoloration-color-compounds-formed-during-greening-of-processed-garlic
#11
Roman Kubec, Petr Curko, Petra Urajová, Josep Rubert, Jana Hajslova
Structures and formation pathways of compounds responsible for blue-green discoloration of processed garlic were studied in model systems. A procedure was developed for isolation of the color compounds and their tentative identification by HPLC-DAD-MS/MS. It was found that the pigment is a mixture of numerous pyrrole-based purple/blue and yellow species. Experiments with isotope-labeled precursors revealed that two molecules of an amino acid are involved in the formation of each color compound. In the purple/blue species (λmax 565-600 nm), both amino acid molecules are incorporated into two 3,4-dimethylpyrrole-derived rings linked together by a propenylidine bridge...
November 6, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29104390/an-in-vitro-comparative-evaluation-of-efficacy-of-disinfecting-ability-of-garlic-oil-neem-oil-clove-oil-and-tulsi-oil-with-autoclaving-on-endodontic-k-files-tested-against-enterococcus-faecalis
#12
Shivayogi Hugar, Punit M Patel, Jyoti Nagmoti, Chaitanya Uppin, Laresh Mistry, Neha Dhariwal
Aim: To comparatively evaluate the efficacy of disinfecting ability of garlic oil, neem oil, clove oil, and tulsi oil with autoclaving on endodontic K files tested against Enterococcus faecalis. Materials and methods: Fifty endodontic K files were exposed to the test micro-organism and checked for its disinfecting ability using three different methods. Result: Garlic oil, clove oil, tulsi oil and autoclave showed considerable effectiveness against E...
July 2017: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/29104381/comparison-of-antimicrobial-efficacy-of-green-tea-garlic-with-lime-and-sodium-fluoride-mouth-rinses-against-streptococcus-mutans-lactobacilli-species-and-candida-albicans-in-children-a-randomized-double-blind-controlled-clinical-trial
#13
Ann Thomas, Sneha Thakur, Rishika Habib
Introduction: With greater awareness worldwide, the use of herbs and herbal products has increased to a large extent. Objective: To evaluate and compare the antimicrobial efficacy of green tea, garlic with lime, and 0.05% sodium fluoride (NaF) mouth rinses against Streptococcus mutans, Lactobacilli species, and Candida albicans. Materials and methods: A total of 45 children aged 4 to 6 years with severe early childhood caries (S-ECC; based on decayed extracted filled [defs] score) were selected...
July 2017: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/29101799/s-allyl-cysteine-improves-clinical-and-neuropathological-features-of-experimental-autoimmune-encephalomyelitis-in-c57bl-6-mice
#14
Hossein Zeinali, Tourandokht Baluchnejadmojarad, Soudabeh Fallah, Mohsen Sedighi, Nariman Moradi, Mehrdad Roghani
Multiple sclerosis (MS) is a deleterious autoimmune and demyelinating disorder of the central nervous system with debilitating sensory and motor complications. There is still no definite cure for it and the main focus for its treatment mostly pivots around subsiding its severity and recurrence. Experimental autoimmune encephalomyelitis (EAE) is an established animal model of MS. S-allyl cysteine (SAC) is the active and main constituent of aged garlic extract with anti-inflammatory and neuroprotective property...
November 1, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29077629/mechanism-of-action-of-topical-garlic-on-wound-healing
#15
Minhal Alhashim, Jamie Lombardo
BACKGROUND: Allicin, the active component of garlic, has been shown to have antimicrobial and anti-inflammatory properties. Garlic has also been used historically by many cultures to heal wounds. Several animal studies have shown that garlic extracts increase the rate of wound healing and decrease the rate of infection. OBJECTIVE: Fibroblasts play a key role in wound healing. Here we hypothesize that fibroblasts are being activated by allicin, leading to more organized and rapid wound repair...
October 26, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29064558/effect-of-different-light-spectra-on-the-pigmentation-of-stored-elephant-garlic
#16
Diego Comparini, Hieu T H Nguyen, Kota Ueda, Kyoshi Moritaka, Toshihiko Kihara, Kawano Tomonori
BACKGROUND: In the present study high-brightness light emitting diodes (HB-LEDs) have been used to investigate the influence of different light spectra on garlic discoloration at different humidity and temperature. Many processes involved in the discoloration process of garlic/leek during storage at different conditions remain unanswered. For this reason in this study the ability of specific light spectra to enhance the production of desirable pigments has been evaluated in the Elephant Garlic...
October 24, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29056888/effect-of-garlic-supplement-in-the-management-of-type-2-diabetes-mellitus-t2dm-a-meta-analysis-of-randomized-controlled-trials
#17
Juan Wang, Xiuming Zhang, Haili Lan, Weijia Wang
The present study was designed to systematically evaluate the clinical efficacy and safety of garlic supplement in the management of type 2 diabetes mellitus (T2DM). PubMed, EMBASE, the Cochrane Library, and China National Knowledge Internet (CNKI) were searched for relevant randomized controlled trials (RCTs) by using the terms garlic and T2DM up to April 2017. The quality of included RCTs was assessed by the Cochrane tool of risk of bias, and data of outcomes were pooled by REVMAN 5.3. Clinical factors were handled by meta-regression and subgroup analysis, and risk of publication bias was explored by inverted funnel plots...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/29045637/effects-of-feeding-on-different-host-plants-and-diets-on-bradysia-odoriphaga-population-parameters-and-tolerance-to-heat-and-insecticides
#18
Guodong Zhu, Yin Luo, Ming Xue, Haipeng Zhao, Xia Sun, Xinhui Wang
Bradysia odoriphaga Yang et Zhang, the Chinese chive root maggot, is a devastating pest of agricultural plants causing significant losses in vegetable crops, edible mushrooms, and humus. To determine the effects of feeding on different host plants and diets on the life parameters of B. odoriphaga and its tolerance to stressful conditions, we analyzed the life-table data of B. odoriphaga reared on Chinese chive (Allium hookeri), Welsh onion (Allium fistulosum), garlic (Allium sativum), oyster mushroom (Pleurotus ostreatus), and humus and assayed its tolerance to heat and insecticides...
October 17, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29043224/optimization-of-mixing-ratio-to-improve-antioxidant-activity-of-aged-garlic-with-pine-needle-using-response-surface-methodology
#19
Jae-Hee Park, Eunji Shin, Eunju Park
Aged garlic has been reported to possess beneficial pharmacological activities, including anti-stress and anti-fatigue properties, and to exert protective effects on the cardiovascular system and liver. Pine needles are widely used in folk medicine and as food additives owing to their pharmacological properties such as anti-aging and anti-inflammatory effects. It has long been known that combining certain phytochemicals with other phenols or organic acids can produce synergistic effects. Therefore, the purpose of this study was to develop an optimal formula of aged garlic with added pine needle powder for improved antioxidant activity using the statistical technique of response surface methodology...
September 2017: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/29039335/anti-avian-influenza-virus-h9n2-activity-of-aqueous-extracts-of-zingiber-officinalis-ginger-and-allium-sativum-garlic-in-chick-embryos
#20
Amir Rasool, Muti-Ur-Rehman Khan, Muhammad Asad Ali, Aftab Ahmad Anjum, Ishtiaq Ahmed, Asim Aslam, Ghulam Mustafa, Saima Masood, Muhammad Amjad Ali, Muhammad Nawaz
In the present study, anti-Avian influenza virus H9N2 activity of aqueous extracts (5, 10, 15, 20, 25%) of Zingiber officinalis and Allium sativum was evaluated. Embryo-toxicity was evaluated by histopathological scoring of Chorio-allantoic membrane of chick embryos. Cytotoxicity of extracts was determined by MTT assay on Vero cells. Aqueous extract of ginger had antiviral activity at 10, 15, 20 and 25% while garlic had activity at 15, 20 and 25%. Histopathological scoring of chorio-allantoic membrane for aqueous extracts (5, 10, 15, 20, 25%) of ginger (0...
July 2017: Pakistan Journal of Pharmaceutical Sciences
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