Read by QxMD icon Read


Anisur Rahman, Mohammad Akbar Faqeerzada, Byoung-Kwan Cho
BACKGROUND: Allicin and soluble solid content (SSC) in garlic is the responsible for its pungent flavor and odor. However, current conventional methods such as high-pressure liquid chromatography (HPLC), refractometer has a critical drawbacks in that they are time-consuming, labor-intensive and destructive procedures. The present study aimed to predict the allicin and soluble solid content (SSC) in garlic using hyperspectral imaging in combination with variable selection algorithms and calibration models...
March 14, 2018: Journal of the Science of Food and Agriculture
Lijun Yang, Min Yang, Siying Li, Zhongxi Zhao
Posaconazole is a broad-spectrum antibacterial drug for the treatment of invasive fungal infections. However, its clinical usage is limited by a lot of adverse reactions such as diarrhea. S-allylmercaptocysteine (SAMC), a garlic organosulfur compound, has a strong antioxidative and anti-inflammatory activity. This study aimed to examine the protective effects of SAMC on posaconazole-induced adverse effects. Mice were treated with the blank control, enteric coated posaconazole microparticles (POS group) and its combination with SAMC (Combination group)...
March 8, 2018: International Immunopharmacology
Ang Li, Yan Liu, Xiaosong Zhu, Xiao Sun, Xiuli Feng, Dawei Li, Jiangqiang Zhang, Meihua Zhu, Zhongxi Zhao
Although the organosulfur compounds from garlic have shown diverse pharmacological activities, the prototype drug was almost undetectable in vivo. As known, methylallyl sulfone (AMSO2) is the main metabolite of some active organosulfur compounds derived from garlic. The purpose of this article was to study the protective effect of AMSO2 on cigarette smoke extract (CSE) induced cell apoptosis in lungs in vivo and in vitro. The male rats were injected intraperitoneally with 900 μL of 100% CSE 3 times for three successive weeks...
March 7, 2018: Biochemical and Biophysical Research Communications
Abebe Basazn Mekuria, Sewunet Admasu Belachew, Henok Getachew Tegegn, Dawit Simegnew Ali, Adeladlew Kassie Netere, Eskedar Lemlemu, Daniel Asfaw Erku
BACKGROUND: Type 2 Diabetes Mellitus (T2DM) patients are increasingly using herbal remedies due to the fact that sticking to the therapeutic regimens is becoming awkward. However, studies towards herbal medicine use by diabetic patients is scarce in Ethiopia. Therefore, the aim of the current study was to explore the prevalence and correlates of herbal medicine use with different sociodemographic variables among type 2 diabetes patients visiting the diabetic follow-up clinic of University of Gondar comprehensive specialized hospital (UOGCSH), Ethiopia...
March 9, 2018: BMC Complementary and Alternative Medicine
Ganiyu Oboh, Adedayo O Ademiluyi, Odunayo M Agunloye, Ayokunle Olubode Ademosun, Bolaji Grace Ogunsakin
Spices are used in soup preparation in many homes and serve as ingredients in the preparation of several traditional delicacies endowed with natural antioxidants such as polyphenols. The aim of this study is to evaluate the effect of aqueous extract of garlic, white onion, and purple onion on angiotensin-converting enzyme, α-amylase, and α-glucosidase activity in vitro and determine their antioxidant properties via various antioxidant assays such as OH* , Fe2+ chelation, and 2, 2'-azino-bis 3-ethylbenzothiazoline-6-sulphonic acid (ABTS) radical-scavenging assays...
March 9, 2018: Journal of Dietary Supplements
Małgorzata Iciek, Magdalena Górny, Anna Bilska-Wilkosz, Danuta Kowalczyk-Pachel
Aldehyde dehydrogenase (ALDH) catalyzes the critical step of ethanol metabolism, i.e. transformation of toxic acetaldehyde to acetic acid. It is a redox sensitive protein with the key Cys in its active site. Recently, it has been documented that activity of some proteins can be modified by sulfur-containing molecules called reactive sulfur species leading to the formation of hydro- persulfides. The aim of the present study was to examine whether ALDH activity can be modified in this way. Studies were performed in vitro using yeast ALDH and various reactive sulfur species, including Na2 S, GSSH, K2 Sx , Na2 S2 O3 , and garlic-derived allyl sulfides...
March 9, 2018: Acta Biochimica Polonica
Masashi Nakamoto, Takuto Fujii, Toshiaki Matsutomo, Yukihiro Kodera
We analyzed aged garlic extract (AGE) to understand its complex sulfur chemistry using post-column high-performance liquid chromatography with an iodoplatinate reagent and liquid chromatography high resolution mass spectrometry (LC-MS). We observed unidentified peaks of putative sulfur compounds. Three compounds were isolated and identified as γ-glutamyl-γ-glutamyl-S-methylcysteine, γ-glutamyl-γ- glutamyl-S-allylcysteine (GGSAC) and γ-glutamyl-γ-glutamyl-S-1-propenyl- cysteine (GGS1PC) by nuclear magnetic resonance and LC-MS analysis using based on comparisons with chemically synthesized reference compounds...
March 2, 2018: Journal of Agricultural and Food Chemistry
Thi Van Anh Nguyen, Hidefumi Yoshii
The stability of allyl sulfide, an organosulfur compound present in garlic oil, in its α-, β-, and γ-cyclodextrin inclusion complexes was investigated under various storage conditions. The complexes of cyclodextrins and allyl sulfide were prepared by spray drying. The storage temperature, relative humidity, and initial moisture content of the inclusion complex had different effects on the release rate of allyl sulfide. Allyl sulfide in α-cyclodextrin complexes had a lower release rate than in β- and γ-cyclodextrin complexes at 100 °C and at 50 °C under 6, 40, 54, and 73% relative humidity...
March 2, 2018: Bioscience, Biotechnology, and Biochemistry
E M Abdelfattah, G Vezzoli, G Buczkowski, M M Makagon
The northern fowl mite (NFM), Ornithonyssus sylviarum (Mesostigmata: Macronyssidae), is the primary blood-feeding ectoparasite found on poultry in the U.S.A. Three experiments were conducted in vitro to test the acaricidal properties of cade, garlic, lavender, lemongrass, pine and thyme essential oils against NFM, and to evaluate whether these effects are altered by adjusting oil application rates and application modality (direct vs. vapour contact). Applied at the rate of 0.21 mg/cm2 , the essential oils of cade, thyme, lemongrass and garlic resulted in higher NFM mortality at 24 h post-application than lavender and pine oils, and the untreated and ethanol-treated controls...
March 2, 2018: Medical and Veterinary Entomology
Yusuke Amino, Hidehiko Wakabayashi, Satoko Akashi, Yutaka Ishiwatari
The structures, flavor-modifying effects, and CaSR activities of γ-glutamyl peptides comprising sulfur-containing amino acids were investigated. The chemical structures, including the linkage mode of the N-terminal glutamic acid, of γ-L-glutamyl-S-(2-propenyl)-L-cysteine (γ-L-glutamyl-S-allyl-L-cysteine) and its sulfoxide isolated from garlic were established by comparing their NMR spectra with those of authentic peptides prepared using chemical methods. Mass spectrometric analysis also enabled determination of the linkage modes in the glutamyl dipeptides by their characteristic fragmentation...
March 2018: Bioscience, Biotechnology, and Biochemistry
Mohd Faizan Siddiqui, Bilqees Bano
Carbendazim is a broad spectrum benzimidazole fungicide which is used to ensure plants' protection from pest and pathogens' invasion. The present work describes the impact of carbendazim (CAR) on garlic phytocystatin (GPC) which is a crucial plant regulatory protein. Interaction of carbendazim with GPC has been investigated through various biophysical techniques viz. UV absorption, fluorescence spectroscopy, isothermal titration calorimetry, far-UV circular dichroism and FTIR spectroscopy which showed binding between them with consequent modulatory effects...
February 2018: Pesticide Biochemistry and Physiology
D Arumai Selvan, D Mahendiran, R Senthil Kumar, A Kalilur Rahiman
Phyto-synthesis of silver nanoparticles (AgNPs) was achieved using aqueous garlic, green tea and turmeric extracts, and characterized by different spectroscopic techniques. Phytochemical analysis revealed the presence of rich amount of biochemicals in these extracts, which serve as reducing and capping agents for converting silver nitrate into AgNPs. FT IR spectroscopy confirmed the role of biomolecules in the bioreduction and efficient stabilization of AgNPs. UV-Vis DRS spectra showed a band around 450 nm characteristics of AgNPs...
February 14, 2018: Journal of Photochemistry and Photobiology. B, Biology
Baiqiang Zhai, Chuanhai Zhang, Yao Sheng, Changhui Zhao, Xiaoyun He, Wentao Xu, Kunlun Huang, Yunbo Luo
Alliin (S-allyl cysteine sulfoxide) is a bioactive sulfoxide compound derived from garlic. To evaluate the preventive effect of alliin against metabolic risk factors in diet induced obese (DIO) mice, we treated the C57BL/6J DIO mice with drinking water with or without alliin (0.1 mg/ml) for 8 weeks. Results showed that alliin had no significant effect on the body weight, adiposity or energy balance. However, alliin treatment enhanced glucose homeostasis, increased insulin sensitivity and improved the lipid profile in the DIO mice...
February 23, 2018: Scientific Reports
Mahmoud Younis, Diaeldin Abdelkarim, Assem Zein El-Abdein
Drying of garlic slices in thin-layer have been studied with Infrared (IR) at 0.075, 0.15, 0.225 and 0.3 W cm-2 radiation intensity and 0.75 and 1.25 m s-1 air flow velocity. The results showed increasing in drying rate and decreasing at the time of drying with decreasing air flow velocity and increasing IR radiation intensity. The effective moisture diffusivity (Deff ) was obtained using Fick's diffusion equation and its mean values ranged between 5.83×10-11 and 7.66×10-10 m2  s-1 for all investigated conditions...
February 2018: Saudi Journal of Biological Sciences
Ko-Chao Lee, Chih-Chuan Teng, Chien-Heng Shen, Wen-Shih Huang, Chien-Chang Lu, Hsing-Chun Kuo, Shui-Yi Tung
Black garlic has been reported to show multiple bioactivities against the development of different diseases. In the present study, the hepatoprotective effect of black garlic on injured liver cells was investigated. Rat clone-9 hepatocytes were used for all experiments; tert-Butyl hydroperoxide (tBHP) was used to induce injury of rat clone-9 hepatocytes. The contents of malondialdehyde (MDA) and glutathione (GSH); anti-oxidative enzyme activities of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx); and mRNA expression levels of interleukin (IL)-6 and IL-8 in rat clone-9 hepatocytes were determined to evaluate the level of cell damage...
March 2018: Experimental and Therapeutic Medicine
Yong Ji, Peijun Wu, Jie Zhang, Jun Zhang, Youfeng Zhou, Yongwen Peng, Shifeng Zhang, Gaotang Cai, Guiqing Gao
In this research, Ganzhou Chinese Cabbage (Brassica rapa pekinensis), Native Purple Garlic (Allium sativum L) and Leping Radish (Raphanus sativus L) widely planted and distributed along the Le'an River were chosen in the present study. Soil physical-chemical properties, nutrients contents as well as heavy metals elements accumulated in both soils and vegetables collected from 24 sites were analyzed by lab analysis combined with statistical method which was also used for calculation of contamination factor, pollution indexes and hazardous index...
February 8, 2018: Chemosphere
Yinglan Peng, Ke Hu
The present study investigated the effect of garlic (G) on serum, liver, renal and cerebral parameters of rats with chronic intermittent hypoxia (CIH) combined with diabetes mellitus (DM). A total of 32 rats were divided into eight groups, with 4 rats/group. A total of three models were established, including CIH, DM and CIH‑DM, and an additional healthy control (C) group. Rats in C‑G, CIH‑G, DM‑G and CIH‑DM‑G groups were injected with a G extract daily. Serum, liver, renal and cerebral parameters were detected...
February 7, 2018: Molecular Medicine Reports
Chenlong Li, Hanguang Jing, Guangtao Ma, Peng Liang
Allicin is an extract purified from Allium sativum (garlic), and previous research has indicated that Allicin has an inhibitory effect on many kinds of tumor cells. The aim of the present study was to explore the anticancer activity of Allicin on human glioma cells and investigate the underlying mechanism. MTT and colony-formation assays were performed to detect glioma cell proliferation, and explore the effect of Allicin at various doses and time-points. The apoptosis of glioma cells was measured by fluorescence microscopy with Hoechst 33258 staining, and then flow cytometry was used to analyzed changes in glioma cell apoptosis...
February 2, 2018: Molecular Medicine Reports
Liming Zhang, Ping Guan, Zhihan Zhang, Yujie Dai, Limin Hao
Complexes of amylose (Am) with garlic bioactive components (GBCs) were prepared by milling activating treatment of Am and garlic paste (GP) together. The complex, produced by milling for 2.5h with the garlic (dry basis)/Am ratio of 1:5 (w/w) and water content of 25% (w/w) exhibited significantly higher allicin content (0.49mg/g of complex) than others. The scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transforms infrared (FT-IR), differential scanning calorimetry (DSC), thermogravimetry analysis (TGA), high performance liquid chromatography (HPLC), and gas chromatography-mass spectrometry (GC-MS) techniques were used complex characterization...
March 2018: Food Research International
Hao Zhang, Ping Wang, Yixue Xue, Libo Liu, Zhen Li, Yunhui Liu
In middle and old age, Alzheimer's disease (AD) is a progressive neurodegenerative disorder of brain. As an increasingly aging population, AD represents a huge burden for the patients' family and the country. However, current therapeutical strategies have shown limited effectiveness. Allicin, which is the main composition of garlic, was reported to prevent the learning and memory impairment of AD mouse model. As the mechanism is not clear, in this study, we used the APP (amyloid precursor protein)/PS1 (presenilin 1) double transgenic mice, which express human mutant APP and PS1, to determine the protective effect of allicin on neurons...
February 2018: Tissue & Cell
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"