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https://www.readbyqxmd.com/read/28543822/good-for-the-lung-but-bad-for-the-liver-garlic-induced-hepatotoxicity-following-liver-transplantation
#1
S A Shaikh, S Tischer, E K Choi, R J Fontana
WHAT IS KNOWN AND OBJECTIVE: Limited data exist surrounding the metabolism and safety of garlic supplements. CASE DESCRIPTION: A patient with a history of hepatopulmonary syndrome (HPS) and orthotopic liver transplantation was admitted to our surgery transplant service with severe hypoxaemia. The patient was started on high-dose Garlicin Cardio(®) (Allium sativum) for HPS and soon after had elevated liver function tests. Garlicin Cardio(®) was discontinued and liver enzymes normalized...
May 25, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28543032/influence-of-different-wild-garlic-allium-ursinum-extracts-on-the-gastrointestinal-system-spasmolytic-antimicrobial-and-antioxidant-properties
#2
Dragana R Pavlović, Milica Veljković, Nikola M Stojanović, Marija Gočmanac-Ignjatović, Tatjana Mihailov-Krstev, Suzana Branković, Dušan Sokolović, Mirjana Marčetić, Niko Radulović, Mirjana Radenković
OBJECTIVES: As there are no previous studies of the European wild-garlic (Allium ursinum) effects on the gastrointestinal system, despite its traditional applications in gastrointestinal disorders' treatment and regular use in the human diet, we have quantified and compared spasmolytic, antimicrobial and antioxidant activities of its different leaf extracts. METHODS: Wild-garlic extracts were tested for spasmolytic activity on isolated rat ileum, antimicrobial activity on selected Gram-positive and Gram-negative bacteria and fungi by microdilution method and antioxidant capacity by DPPH radical-scavenging assay...
May 23, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28541356/food-and-plant-bioactives-for-reducing-cardiometabolic-disease-risk-an-evidence-based-approach
#3
REVIEW
Arrigo F G Cicero, Federica Fogacci, Alessandro Colletti
Cardiovascular diseases (CVDs) are one of the major causes of mortality and disability in Western countries. Prevention is known to be the cornerstone to lessen the incidence of CVDs and also to reduce the economic burden of both the citizen and the healthcare system. "Interventional medicine" certainly puts lifestyle modification as the first therapeutic step, including a healthy diet and physical activity. Secondly, a large body of research individuated a number of food and plant bioactives, which are potentially efficacious in preventing and reducing some highly prevalent CV risk factors, such as hypercholesterolemia, hypertension, vascular inflammation and vascular compliance...
May 25, 2017: Food & Function
https://www.readbyqxmd.com/read/28536879/effects-of-dietary-intake-of-garlic-on-intestinal-trematodes
#4
Alba Cortés, Miguel García-Ferrús, Javier Sotillo, J Guillermo Esteban, Rafael Toledo, Carla Muñoz-Antolí
The current strategy for the control of helminth infections relies on chemotherapy. However, resistance appearance is promoting the necessity of developing new drugs against trematodes. Herein, potential trematocidal effects of garlic (Allium sativum) are investigated in the context of intestinal foodborne trematodes, employing the Echinostoma caproni-mouse model. Daily administration of dietary doses of garlic was conducted in three groups of mice: (i) before infection (prophylaxis), (ii) after infection (therapeutic) and (iii) both, before and after infection (continuous)...
May 23, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28535590/emission-of-volatile-organic-compounds-and-production-of-secondary-organic-aerosol-from-stir-frying-spices
#5
Tengyu Liu, Qianyun Liu, Zijun Li, Lei Huo, ManNin Chan, Xue Li, Zhen Zhou, Chak K Chan
Cooking is an important source of volatile organic compounds (VOCs) and a potential source of secondary organic aerosol (SOA) both indoors and outdoors. In this study, VOC emissions from heating corn oil and stir-frying spices (i.e. garlic, ginger, myrcia and zanthoxylum piperitum (Sichuan pepper)) were characterized using an on-line membrane inlet vacuum ultraviolet single-photon ionization time-of-flight mass spectrometer (VUV-SPI-TOFMS). VOC emissions from heating corn oil were dominated by aldehydes, which were enhanced by factors of one order of magnitude when stir-frying spices...
May 19, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28530769/beneficial-effects-of-garlic-allium-sativum-oil-in-experimental-corrosive-esophageal-burns-effects-of-garlic-oil-in-esophageal-burns
#6
Ceren Şen Tanrıkulu, Yusuf Tanrikulu, Fahriye Kılınç, Burak Bahadır, Murat Can, Füruzan Köktürk
BACKGROUND: Corrosive esophageal burns, particularly common in developing countries, lead to different problems in different age groups. The ingestion of corrosive substances can cause such problems as stricture of the esophagus, to acute perforation, and even death. Because stricture formation is related to the severity of the initial injury, the prevention of stricture constitutes a main goal of treatment. The aim of this study was to investigate the protective and anti-inflammatory effects of garlic (Allium sativum) oil in corrosive esophageal burn...
May 2017: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/28524727/e-cadherin-%C3%AE-catenin-complex-a-target-for-anticancer-and-antimetastasis-plants-plant-derived-compounds
#7
Majid Tafrihi, Roohollah Nakhaei Sistani
Plants reputed to have cancer-inhibiting potential and putative active components derived from those plants have emerged as an exciting new field in cancer study. Some of these compounds have cancer-inhibiting potential in different clinical staging levels, especially metastasis. A few of them which stabilize cell-cell adhesions are controversial topics. This review article introduces some effective herbal compounds that target E-cadherin/β-catenin protein complex. In this article, at first, we briefly review the structure and function of E-cadherin and β-catenin proteins, Wnt signaling pathway, and its target genes...
May 19, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28507945/antimicrobial-activity-of-two-garlic-species-allium-sativum-and-a-tuberosum-against-staphylococci-infection-in-vivo-study-in-rats
#8
Paulo César Venâncio, Sidney Raimundo Figueroba, Bruno Dias Nani, Luiz Eduardo Nunes Ferreira, Bruno Vilela Muniz, Fernando de Sá Del Fiol, Adilson Sartoratto, Edvaldo Antonio Ribeiro Rosa, Francisco Carlos Groppo
Purpose: This study observed the effect of garlic extracts and amoxicillin against an induced staphylococcal infection model. MIC and MBC were also obtained for aqueous extracts of Allium sativum (Asa) and Allium tuberosum (Atu) against Staphylococcus aureus penicillin-sensitive (PSSA - ATCC 25923) and MRSA (ATCC 33592). Methods: Granulation tissues were induced in the back of 205 rats. After 14 days, 0.5 mL of 10(8) CFU/mL of PSSA or MRSA were injected inside tissues. After 24h, animals were divided: G1 (Control) - 0...
April 2017: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28507406/evaluation-of-different-agroindustrial-waste-on-the-effect-of-different-carcass-characteristics-and-physiological-and-biochemical-parameters-in-broilers-chicken
#9
Y Sánchez-Roque, Y D C Pérez-Luna, E Pérez-Luna, R Berrones Hernández, S Saldaña-Trinidad
AIM: This study was conducted to evaluate the physiological and biochemical effect in chickens of the Ross breed of a food enriched with agroindustrial waste. MATERIALS AND METHODS: The food is one of the main components of the total cost for the production of chickens. Rations should be formulated to provide the correct balance of energy, protein, amino acids, minerals, vitamins and essential fatty acids, to allow optimal growth and performance. This study was intended to evaluate a natural feed for chicken, made from corn, yucca meal, eggshells, orange peel, soybean meal, salt and garlic, enriched with agroindustrial waste (molasses, milk whey and ferment of coffee)...
April 2017: Veterinary World
https://www.readbyqxmd.com/read/28502851/inhibitory-effect-of-alliin-from-allium-sativum-on-the-glycation-of-superoxide-dismutase
#10
Shehwaz Anwar, Hina Younus
Inhibition of glycation is an important approach for alleviating diabetic complications. Alliin, the most abundant sulphur compound in garlic has been demonstrated to possess antidiabetic activity. However, there is no scientific evidence supporting its antiglycating activity. The objective of this study was to determine the inhibitory effect of alliin on glucose and methyglyoxal (MG)-induced glycation of an important antioxidant enzyme, superoxide dismutase (SOD). Glycation of SOD resulted in a decrease in enzyme activity, fragmentation/cross-linking, reduced cross-reactivity with anti-SOD antibodies, both tertiary and secondary structural changes, and formation of AGEs and fibrils...
May 11, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28501767/garlic-derived-organosulfur-compound-exerts-antitumor-efficacy-via-activation-of-mapk-pathway-and-modulation-of-cytokines-in-sgc-7901-tumor-bearing-mice
#11
Xiaoyan Jiang, Xiaosong Zhu, Weizhen Huang, Hongya Xu, Zhongxi Zhao, Siying Li, Shanzhong Li, Jianhua Cai, Jimin Cao
Diallyl trisulfide (DATS), a natural agent derived from garlic, has been tested for its antigastric cancer activities in various preliminary studies. However, more systematic pharmacodymatic (PD) and mechanistic evaluations are clearly needed. The aim of this study was to investigate the antitumor effects of DATS in the treatment of human gastric cancer cell SGC-7901 both in vitro and in vivo using widely recommended study procedures. DATS suppressed cancer cells proliferation and induced cell cycle arrest accompanied by an increase in the expressions of cyclin A2 and cyclin B1 in SGC-7901 cancer cells...
May 11, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28500963/sensory-profiling-of-low-sodium-frankfurter-containing-garlic-products-adequacy-of-polarized-projective-mapping-compared-with-trained-panel
#12
C N Horita, E A Esmerino, V A S Vidal, J S Farah, G V Amaral, H M A Bolini, A G Cruz, M A R Pollonio
No abstract text is available yet for this article.
May 4, 2017: Meat Science
https://www.readbyqxmd.com/read/28498422/garlic-extract-in-bladder-cancer-prevention-evidence-from-t24-bladder-cancer-cell-xenograft-model-tissue-microarray-and-gene-network-analysis
#13
Won Tae Kim, Sung-Pil Seo, Young Joon Byun, Ho-Won Kang, Yong-June Kim, Sang-Cheol Lee, Pildu Jeong, Yoonhee Seo, Soo Young Choe, Dong-Joon Kim, Seon-Kyu Kim, Sung-Kwon Moon, Yung-Hyun Choi, Geun Taek Lee, Isaac Yi Kim, Seok Joong Yun, Wun-Jae Kim
There is a growing interest in the use of naturally occurring agents in cancer prevention. This study investigated the garlic extract affects in bladder cancer (BC) prevention. The effect of garlic extract in cancer prevention was evaluated using the T24 BC BALB/C-nude mouse xenograft model. Microarray analysis of tissues was performed to identify differences in gene expression between garlic extract intake and control diet, and gene network analysis was performed to assess candidate mechanisms of action. Furthermore, we investigated the expression value of selected genes in the data of 165 BC patients...
May 11, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28496966/effects-of-deer-on-the-photosynthetic-performance-of-invasive-and-native-forest-herbs
#14
J Mason Heberling, Nathan L Brouwer, Susan Kalisz
Overabundant generalist herbivores can facilitate non-native plant invasions, presumably through direct and indirect modifications to the environment that affect plant performance. However, ecophysiological mechanisms behind ungulate-mediated plant invasions have not been well-studied. At a long-term Odocoileus virginianus (white-tailed deer) exclusion site in a temperate deciduous forest, we quantified deer-mediated ecophysiological impacts on an invasive biennial Alliaria petiolata (garlic mustard) and two palatable native herbaceous perennials, Maianthemum racemosum and Trillium grandiflorum...
March 2017: AoB Plants
https://www.readbyqxmd.com/read/28492800/fungal-infection-control-by-garlic-extracts-allium-sativum-l-and-modulation-of-peritoneal-macrophages-activity-in-murine-model-of-sporotrichosis
#15
J P Burian, L V S Sacramento, I Z Carlos
Garlic (Allium sativum L.) is grown all over the world as seasoning and medicinal vegetable since 3,000 BC. Allicin is the main component of garlic, being attributed to it the most of its biological activities, such as bactericidal, antifungal and antiviral actions. However, other compounds of garlic present antioxidant, hypocholesterolemic, vasodilator activities, protective action against different types of cancer, and immunomodulatory. Fungal infections are important causes of morbidity and mortality in people mainly in immunosuppressed ones...
May 4, 2017: Brazilian Journal of Biology, Revista Brasleira de Biologia
https://www.readbyqxmd.com/read/28490150/a-simple-and-sensitive-vortex-assisted-ionic-liquid-dispersive-microextraction-and-spectrophotometric-determination-of-selenium-in-food-samples
#16
Esra Bağda, Mustafa Tüzen
In the present study, a novel and eco-friendly vortex-assisted ionic liquid-based microextraction method was developed for the determination of selenium in food. The microextraction method is based on the liberation of iodine in the presence of selenium; the liberated iodine reacts with I(-) to form I3(-). Anionic I3(-) reacts with cationic crystal violet dye, and the product is extracted into 1-hexyl-3-methylimidazolium hexafluorophosphate phase in the presence of Triton X-114. The proposed method is linear in the range of 2...
October 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28489336/antimicrobial-activity-of-natural-products-against-clostridium-difficile-in-vitro
#17
Niloufar Roshan, Thomas V Riley, Katherine A Hammer
AIMS: To investigate the antimicrobial activity of various natural products against C. difficile in vitro. METHODS AND RESULTS: The antibacterial activity of 20 natural products was determined by the agar well diffusion and broth microdilution assays against four C. difficile strains, three comparator organisms and four gastrointestinal commensal organisms. Of the raw natural products, garlic juice had the highest activity. The most active processed products were peppermint oil and the four pure compounds trans-cinnamaldehyde, allicin, menthol and zingerone...
May 10, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28489057/an-optimized-facile-procedure-to-synthesize-and-purify-allicin
#18
Frank Albrecht, Roman Leontiev, Claus Jacob, Alan J Slusarenko
Allicin is a reactive sulfur species (RSS) and defence substance from garlic (Allium sativum L.). The compound is a broad-spectrum antibiotic that is also effective against multiple drug resistant (MDR) strains. A detailed protocol for allicin synthesis based on diallyl-disulfide (DADS) oxidation by H₂O₂ using acetic acid as a catalyst was published in 2001 by Lawson and Wang. Here we report on improvements to this basic method, clarify the mechanism of the reaction and show that it is zero-order with respect to DADS and first-order with respect to the concentration of H₂O₂...
May 10, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28481316/phytochemical-profiles-and-antimicrobial-activities-of-allium-cepa-red-cv-and-a-sativum-subjected-to-different-drying-methods-a-comparative-ms-based-metabolomics
#19
Mohamed A Farag, Sara E Ali, Rashad H Hodaya, Hesham R El-Seedi, Haider N Sultani, Annegret Laub, Tarek F Eissa, Fouad O F Abou-Zaid, Ludger A Wessjohann
Plants of the Allium genus produce sulphur compounds that give them a characteristic (alliaceous) flavour and mediate for their medicinal use. In this study, the chemical composition and antimicrobial properties of Allium cepa red cv. and A. sativum in the context of three different drying processes were assessed using metabolomics. Bulbs were dried using either microwave, air drying, or freeze drying and further subjected to chemical analysis of their composition of volatile and non-volatile metabolites. Volatiles were collected using solid phase micro-extraction (SPME) coupled to gas chromatography-mass spectrometry (GC/MS) with 42 identified volatiles including 30 sulphur compounds, four nitriles, three aromatics, and three esters...
May 8, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28479370/yap1p-the-central-regulator-of-the-s-cerevisiae-oxidative-stress-response-is-activated-by-allicin-a-natural-oxidant-and-defence-substance-of-garlic
#20
Martin C H Gruhlke, Ivan Schlembach, Roman Leontiev, Andreas Uebachs, Peter U G Gollwitzer, Alexander Weiss, Agnes Delaunay, Michel Toledano, Alan J Slusarenko
Allicin is a thiol-reactive sulfur-containing natural product from garlic with a broad range of antimicrobial effects against prokaryotes and eukaryotes. Previous work showed that the S. cerevisiae OSI1 gene is highly induced by allicin and other thiol-reactive compounds, and in silico analysis revealed multiple Yap1p binding motifs in the OSI1 promoter sequence. An OSI1-promoter::luciferase reporter construct expressed in Wt and Δyap1 cells showed absolute Yap1p-dependence for allicin-induced OSI1-expression...
May 4, 2017: Free Radical Biology & Medicine
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