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Assessment Evaluation

Tracy L Leong, Paula M Loveland, Alexandra Gorelik, Louis Irving, Daniel P Steinfort
BACKGROUND: Performance of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) for staging the radiologically normal mediastinum has been reported with inconsistent findings. We assessed the sensitivity of systematic staging using EBUS-TBNA for detection of radiologically occult mediastinal metastases in cN0/N1 lung cancer. METHODS: Studies evaluating EBUS-TBNA for systematic mediastinal staging in cN0/N1 lung cancer were identified by systematic review...
August 16, 2018: Journal of Bronchology & Interventional Pulmonology
Mitsuhiro Tsuritani, Yoshiaki Morita, Takekazu Miyoshi, Kenichi Kurosaki, Jun Yoshimatsu
OBJECTIVE: We attempted to evaluate fetal cardiac activity of congenital heart disease (CHD) and normal heart fetuses by magnetic resonance imaging (MRI). METHODS: We evaluated the fetal cardiac functional assessment and the blood flow of descending aorta at 34 weeks' gestation or more by MRI and compared the results with ultrasonography findings. We measured 6 normal heart fetuses and 14 CHD fetuses. RESULTS: The ejection fraction (EF) and descending aorta blood flow in the CHD group were 76...
August 16, 2018: Journal of Computer Assisted Tomography
Christian Booz, Julian L Wichmann, Sabine Boettger, Ahmed Al Kamali, Simon S Martin, Lukas Lenga, Doris Leithner, Moritz H Albrecht, Hanns Ackermann, Thomas J Vogl, Boris Bodelle, Benjamin Kaltenbach
OBJECTIVE: The aim of this study was to investigate a novel version of a computer-aided diagnosis (CAD) system developed for automated bone age (BA) assessment in comparison to the Greulich and Pyle method, regarding its accuracy and the influence of carpal bones on BA assessment. METHODS: Total BA, BA of the left distal radius, and BA of carpal bones in 305 patients were determined independently by 3 blinded radiologists and assessed by the CAD system. Pearson product-moment correlation, Bland-Altman plot, root-mean-square deviation, and further agreement analyses were computed...
August 16, 2018: Journal of Computer Assisted Tomography
Mohammad Alwardat, Mohammad Etoom, Salameh Al Dajah, Tommaso Schirinzi, Giulia Di Lazzaro, Paola Sinibaldi Salimei, Nicola Biagio Mercuri, Antonio Pisani
The aim of this systematic review and meta-analysis was to evaluate the effectiveness of robot-assisted gait training (RAGT) on motor impairments in people with Parkinson's disease (PD). A computer-based systematic literature search was performed in six databases according to PRISMA guidelines. Randomized controlled trials (RCTs) that assessed the effects of RAGT on motor impairments in people with PD were included. GRADE approach and PEDro scale were used to determine the studies' quality of evidence. Meta-analyses were performed by calculating the weighted mean difference (WMD) at 95% confidence interval...
August 16, 2018: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
Himanshu Gupta
Over the past few years, the need for sustainable environmental management has increased rapidly and green management has emerged as an important tool for the same. The role of Green Human Resource Management (GHRM) practices in environmental management and green management is widely known but still lesser discussed in academic literature. Thus, realizing the importance of GHRM in environmental management by organizations, this study attempts to identify the important practices of GHRM and evaluate the performance of manufacturing organizations using GHRM practices...
August 13, 2018: Journal of Environmental Management
Kai Xu, Chiyuan Ma, Langhai Xu, Jisheng Ran, Lifeng Jiang, Yuzhe He, Safwat Adel Abdo Moqbel, Zhan Wang, Lidong Wu
Osteoarthritis (OA) is a chronic degenerative joint disease that has been shown to be closely related to the over expression of matrix metalloproteinases (MMPs). Polygalacic acid is a triterpene isolated from the root of Polygala tenuifolia Willd. In the present study, the anti-inflammatory effect of polygalacic acid in OA was investigated as well as its in vitro and in vivo mechanism. In vitro, rat chondrocytes were induced with interleukin-1beta (IL-1β) and treated with different concentrations of polygalacic acid; real-time PCR and Western blotting were performed to evaluate the expressions of MMP-3, MMP-9, MMP-13, and COX-2...
August 13, 2018: International Immunopharmacology
Matthew Shupler, William Godwin, Joseph Frostad, Paul Gustafson, Raphael E Arku, Michael Brauer
BACKGROUND: Exposure to household air pollution (HAP) from cooking with dirty fuels is a leading health risk factor within Asia, Africa and Central/South America. The concentration of particulate matter of diameter ≤ 2.5 μm (PM2.5 ) is an important metric to evaluate HAP risk, however epidemiological studies have demonstrated significant variation in HAP-PM2.5 concentrations at household, community and country levels. To quantify the global risk due to HAP exposure, novel estimation methods are needed, as financial and resource constraints render it difficult to monitor exposures in all relevant areas...
August 14, 2018: Environment International
Hiroki Abe, Kento Koyama, Shuso Kawamura, Shigenobu Koseki
Stochastic models take into account the uncertainty and variability of predictions in quantitative microbial risk assessment. However, a model that considers thermal inactivation conditions can better predict whether or not bacteria in food are alive. To this end, we describe a novel probabilistic modelling procedure for accurately predicting thermal end point, in contrast to conventional kinetic models that are based on extrapolation of the D value. We used this new model to investigate changes in the survival probability of Salmonella enterica serotype Oranienburg during thermal processing...
August 8, 2018: International Journal of Food Microbiology
Darrin M Aase, Stephanie M Gorka, Justin E Greenstein, Eric Proescher, Natania A Crane, Llashe-Kaye Everett, Ikram Hassan, Amanda Osborn, Christopher Schroth, Amy Kennedy-Krage, K Luan Phan
BACKGROUND: Rates of comorbid alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD) are increasing among post-9/11 veterans, and emotion regulation problems have been identified as a feature of both disorders. However, no studies to date have explored how individual differences in emotion regulation may moderate the relationship between PTSD symptoms and alcohol use. We evaluated how two core emotion regulation strategies - one adaptive (i.e., cognitive reappraisal) and one maladaptive (i...
August 7, 2018: Drug and Alcohol Dependence
Li Gao, Bo Gao, Dongyu Xu, Wenqi Peng, Jin Lu
Response of trace metals to the consecutive water level fluctuation in the Three Gorges Reservoir (TGR) sediments remains unclear. Here, we evaluated the influence of consecutive stages of water level fluctuation on trace metal pollution using multiple analytical approaches. The spatio-temporal distributions of trace metals in TGR sediments were investigated for five consecutive water impoundment stages from 2015 to 2017. Anthropogenic contributions and trace metal stocks in the TGR were quantitatively estimated using a combination of a regional geochemical baseline (RGB) and annual sediment load...
August 9, 2018: Science of the Total Environment
Rachel M Walker, Brigid M Gillespie, Lukman Thalib, Niall S Higgins, Jennifer A Whitty
BACKGROUND: Pressure injuries are localised areas of injury to the skin and/or underlying tissues. OBJECTIVES: To assess foam dressings compared to other dressings in healing pressure injuries. DESIGN: Systematic review and meta-analysis DATA SOURCES: The review team searched: the Cochrane Wounds Specialised Register; the Cochrane Central Register of Controlled Trials; Ovid MEDLINE; Ovid Embase; EBSCO CINAHL Plus and the NHS Economic Evaluation Database...
July 24, 2018: International Journal of Nursing Studies
Domenico Giacco, Maev Conneely, Tumseela Masoud, Erin Burn, Stefan Priebe
BACKGROUND: Observational research has found that involuntary treatment provides limited benefits in terms of long-term clinical outcomes. Our aim was to review literature on existing interventions in order to identify helpful approaches to improve outcomes of involuntary treatment. METHODS: This systematic review follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement guidelines. Seven databases (AMED, PsycINFO, Embase Classic, Embase 1974-2017, CINAHL, MEDLINE, and BNI) were searched and the results were analysed in a narrative synthesis...
August 14, 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
Fabíola M Barreto, Mariana R da Silva, Patrícia A C Braga, Adriana P A Bragotto, Hamilton Hisano, Felix G R Reyes
Florfenicol is one of the most-used antimicrobial agents in global fish farming. Nevertheless, in most countries, its use is not conducted in accordance with good practices. The aim of this work was to evaluate the leaching of florfenicol from coated fish feed into the water. Analytical methods were developed and validated for the quantitation of florfenicol in medicated feed and water by UHPLC-MS/MS. Florfenicol residues in the water were quantified after 5- and 15-min exposures of the medicated feed in the water at 22 and 28 °C and at pH 4...
August 6, 2018: Environmental Pollution
Rafael Francisco Lia Mondelli, Cristiane Machado de Almeida, Fabio Antonio Piola Rizzante, Ana Flavia Sanches Borges, Sérgio Kiyoshi Ishikiriama, Juliana Fraga Soares Bombonatti
BACKGROUND: Use of hybrid-light (HL) during in-office teeth bleaching can provide faster and reliable results after a single bleaching session, especially if associated with previous acid etching. The present in vivo, interventional, split-mouth, triple-blinded and randomized study evaluated the efficiency of a HL, with and without prior enamel acid etching, assessing the gel application time, degree of color change, sensitivity and treatment stability up to 12 months. METHODS: Thirty-four patients were selected and randomly divided into four groups...
August 14, 2018: Photodiagnosis and Photodynamic Therapy
Praveen Rishi, Shania Vij, Indresh Kumar Maurya, Ujjwal Jit Kaur, Sanjay Bharati, Rupinder Tewari
Fast emerging antibiotic resistance in pathogens requires special attention for strengthening the reservoir of antimicrobial compounds. In view of this, several peptides with known antimicrobial activities have been reported to enhance the efficacy of antibiotics against multidrug resistant (MDR) pathogens. In the present study, potential of peptides having distinct mechanism of action, if any, was evaluated to improve the efficacy of conventional antibiotics against methicillin-resistant S. aureus (MRSA). After primary screening of six peptides, two peptides namely T3 and T4 showing very high minimum inhibitory concentrations (MICs) were selected to assess their role in altering the MICs of antibiotics to which the pathogen was resistant...
August 14, 2018: Microbial Pathogenesis
Yutian Tian, Cengceng Chen, Shuhan Guo, Li Zhao, Yongjian Yan
OBJECTIVE: We explored methods to establish an animal model of manganese poisoning and evaluate the feasibility of the determination method. METHODS: Twenty-four specific pathogen-free male rats were randomly divided into four groups: control, low-dose (15.0 mg/kg), middle-dose (25.0 mg/kg), and high-dose (50.0 mg/kg). Intraperitoneal injection of MnCl2 ·H2 O was administered every 48 hours for three months. Rats were tested for behavior, muscle tension, and with a balance beam experiment at the end of each month...
August 14, 2018: Toxicology
Zana A Carver, Alice A Han, Charles Timchalk, Thomas J Weber, Kimberly J Tyrrell, Ryan L Sontag, Teresa Luders, William B Chrisler, Karl K Weitz, Jordan N Smith
The objective of this study was to evaluate the potential for non-invasive biomonitoring of 2,4-dichlorophenoxyacetic acid (2,4-D) in saliva. Using an in vitro rat salivary gland epithelial cell (SGEC) system, a collection of experiments investigating chemical protein binding, temporal and directional transport, as well as competitive transport with para-aminohippuric acid (PAH), a substrate for renal organic anion transporters, was conducted to identify cellular transport parameters required to computationally model salivary transport of 2,4-D...
August 14, 2018: Toxicology
Bora İrer, Aylin Çelikhisar, Hakan Çelikhisar, Ozan Bozkurt, Ömer Demir
OBJECTIVE: To determine the presence of lower urinary tract symptoms (LUTS), nocturia, sexual dysfunction (SD) and the status of quality of life (QOL) in men with obstructive sleep apnea syndrome (OSAS) and after continuous positive airway pressure (CPAP) treatment, the changes in the presence of these conditions and the improvements of QOL. MATERIEL AND METHODS: In this study, 126 patients with suspicious diagnosis of OSAS were enrolled prospectively. International Prostate Symptom Score (IPSS), International Consultation on Incontinence Questionnaire-Male LUTS (ICIQ-MLUTS), Overactive Bladder Symptoms Score (OABS-V8), Nocturia Quality of Life (Nqol), voiding diary, International Index of Erectile Function (IIEF-15) questionnaire and Short form 36 (SF-36) to assess the presence of SD, LUTS, nocturia and the status of QOL were filled by patients before polysomnography...
August 14, 2018: Urology
José Moreira, Ariane Paixão, Juliana Oliveira, Waldir Jaló, Ofélio Manuel, Rafaela Rodrigues, Alexandra Oliveira, Leonardo Tinoco, João Lima, Beatriz Grinsztejn, Valdiléa G Veloso, André M Japiassú, Cristiane C Lamas
OBJECTIVES: To compare the discriminatory capacity of the quick Sequential Organ Failure Assessment (qSOFA) versus the Systemic Inflammatory Response Syndrome (SIRS) score for predicting 30-day mortality and intensive care unit (ICU) admission in patients with suspicion of infection at an HIV reference center. METHODS: Prospective cohort study including consecutive adult patients who had suspected infection and subsequently admitted to the medical ward. Variables related to qSOFA and SIRS were measured at admission...
August 14, 2018: Clinical Microbiology and Infection
Asako Murayama, Kei Fujiwara, Norie Yamada, Masaaki Shiina, Takahiro Masaki, Masamichi Muramatsu, Takaji Wakita, Takanobu Kato
Nonstructural protein 5A (NS5A) inhibitors of hepatitis C virus (HCV) are known to have potent anti-viral effects; however, these inhibitors have limited activities on strains with resistant-associated substitutions or non-genotype 1 strains. To overcome these shortcomings, novel NS5A inhibitors have been developed and approved for clinical application. The aim of this study was to evaluate the anti-viral effect of novel NS5A inhibitors (derivatives of odalasvir) on HCV genotype 2 strains in a cell culture system...
August 14, 2018: Antiviral Research
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