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Emmanuelle Castagnoli, Johanna Salo, Matti S Toivonen, Tamás Marik, Raimo Mikkola, László Kredics, Alejandro Vicente-Carrillo, Szabolcs Nagy, Markus T Andersson, Maria A Andersson, Jarek Kurnitski, Heidi Salonen
A novel, objective, and rapid computed motility inhibition (CMI) assay was developed to identify and assess sublethal injury in toxin-exposed boar spermatozoa and compared with a subjective visual motility inhibition (VMI) assay. The CMI values were calculated from digital micrographic videos using a custom MATLAB® script by contrasting the motility index values of each experiment with those of the background and control experiments. Following a comparison of the CMI and VMI assays results, it was determined that their agreement depended on the shape of the dose-response curve...
November 8, 2018: Toxins
Vera Schellewald, Jens Kleinert, Rolf Ellegast
The present field study evaluates the use of dynamic workstations (cycling devices) in a real-life office environment. Specific characteristics of use were recorded and possible relationships with short-term changes in well-being were investigated. For a period of 12 weeks, 36 employees were given free access to eight devices. Frequency, duration and speed of use were self-determined but registered objectively for every event of use. Immediately before and after using a cycling device, employees rated their well-being with a modified version of the EZ-scale from Nitsch to assess changes in the short-term...
November 8, 2018: International Journal of Environmental Research and Public Health
Jerzy Gębski, Marzena Jezewska-Zychowicz, Dominika Guzek, Monika Świątkowska, Dagmara Stangierska, Marta Plichta
Short sleep duration appears to put adults at risk of excessive energy intake and obesity; less is known specifically about how sleep quantity relates to dietary patterns. Therefore, the aim of this study was to assess the associations of dietary patterns (DPs) with short sleep duration. The data were collected in November 2016 through a cross-sectional quantitative survey among 972 Polish adults with both normal weight and excessive weight. Principal components analysis (PCA) was conducted to derive DPs. Logistic regression analysis was used to verify associations between short sleep duration (independent variable) and DPs (dependent variables)...
November 8, 2018: International Journal of Environmental Research and Public Health
Yurina Sugita, Tetsuro Miyazaki, Kazunori Shimada, Megumi Shimizu, Mitsuhiro Kunimoto, Shohei Ouchi, Tatsuro Aikawa, Tomoyasu Kadoguchi, Yuko Kawaguchi, Tomoyuki Shiozawa, Kiyoshi Takasu, Masaru Hiki, Shuhei Takahashi, Katsuhiko Sumiyoshi, Hiroshi Iwata, Hiroyuki Daida
BACKGROUND: Delirium is a common occurrence in patients admitted to the intensive care unit and is related to mortality and morbidity. Malnutrition is a predisposing factor for the development of delirium. Nevertheless, whether the nutritional status on admission anticipates the development of delirium in patients with acute cardiovascular diseases remains unknown. OBJECTIVE: This study aims to assess the correlation between the nutritional status on admission using the nutritional index and the development of delirium in the coronary intensive care unit...
November 8, 2018: Nutrients
Paulo J Palma, Joana A Marques, Rui I Falacho, Alexandra Vinagre, João Miguel Santos, João Carlos Ramos
The purpose of the present study was to assess the proper time to perform a restoration (immediately or delayed) after placement of two calcium silicate-based cements (CSCs) and to test the performance of two different restorative protocols regarding shear bond strength (SBS). Seventy-five acrylic blocks were randomly divided into five groups ( n = 15). Specimens were filled with either ProRoot MTA (Dentsply Tulsa Dental) or Biodentine (Septodont). The restoration was performed at an immediate (12 min) or delayed (seven days) timeframe, using a resin-based flowable composite (SDR) (bonded to the CSC using a universal bonding system) or glass ionomer cement (GIC) as restorative materials...
November 8, 2018: Materials
Kumar Jayant, Isabella Reccia, Francesco Virdis, A M James Shapiro
AIM: The livers from DCD (donation after cardiac death) donations are often envisaged as a possible option to bridge the gap between the availability and increasing demand of organs for liver transplantation. However, DCD livers possess a heightened risk for complications and represent a formidable management challenge. The aim of this study was to evaluate the effects of thrombolytic flush in DCD liver transplantation. METHODS: An extensive search of the literature database was made on MEDLINE, EMBASE, Cochrane, Crossref, Scopus databases, and clinical trial registry on 20 September 2018 to assess the role of thrombolytic tissue plasminogen activator (tPA) flush in DCD liver transplantation...
November 8, 2018: Journal of Clinical Medicine
Mohsen Tahmasebi Nasab, Kendall Grimm, Mohammad Hadi Bazrkar, Lan Zeng, Afshin Shabani, Xiaodong Zhang, Xuefeng Chu
Non-point source (NPS) pollution from agricultural lands is the leading cause of various water quality problems across the United States. Particularly, surface depressions often alter the releasing patterns of NPS pollutants into the environment. However, most commonly-used hydrologic models may not be applicable to such depression-dominated regions. The objective of this study is to improve water quantity/quality modeling and its calibration for depression-dominated basins under wet and dry hydroclimatic conditions...
November 8, 2018: International Journal of Environmental Research and Public Health
Zhe Yuan, Jijun Xu, Yongqiang Wang
Projecting future changes in extreme flood is critical for risk management. This paper presented an analysis of the implications of the Fifth Coupled Model Intercomparison Project Phase (CMIP5) climate models on the future flood in the Jinsha River Basin (JRB) in Southwest China, using the Xinanjiang (XAJ) hydrologic model. The bias-corrected and resampled results of the multimodel dataset came from the Inter-Sectoral Impact Model Intercomparison Project (ISI-MIP). Relatively optimal general circulation models (GCMs) were selected with probability density functions (PDFs)-based assessment...
November 8, 2018: International Journal of Environmental Research and Public Health
Guixing Ren, Zhenxing Shi, Cong Teng, Yang Yao
Breast cancer is the most frequently diagnosed cancer in women worldwide. The antiproliferative activities of biochanin A (BA) and ginsenoside Rh₂ were determined by evaluating their inhibitory effect on MDA-MB-231 human breast cancer cell proliferation. The combination of BA with Rh₂ was also assessed. In MDA cells, combination treatment led to a decrease in the EC50 values of BA and Rh₂ to 25.20 μM and 22.75 μM, respectively. In MCF-7 cells, the EC50 values of combined BA and Rh₂ decreased to 27...
November 8, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Xinyan Li, Weichen Li, Lingping Hou
BACKGROUND: The first-line bevacizumab plus chemotherapy resulted in a clinical efficacy for Chinese patients with advanced nonsquamous non-small-cell lung cancer (NSCLC). Some economic analyses have carried out various methods to evaluate the cost-effectiveness of bevacizumab as the first-line treatment for NSCLC in other countries. Our objective was to assess the cost-effectiveness of bevacizumab plus chemotherapy compared with chemotherapy alone for the first-line treatment of advanced nonsquamous NSCLC...
November 6, 2018: Value in Health Regional Issues
Gillian S Gould, Michelle Bovill, Lauren Pollock, Billie Bonevski, Maree Gruppetta, Lou Atkins, Kristin Carson-Chahhoud, Katherine M Boydell, Gabrielle R Gribbin, Chris Oldmeadow, Alix Hall, Yael Bar-Zeev
BACKGROUND: Many health providers (HPs) lack knowledge, confidence, optimism and skills in addressing smoking with pregnant women. This study aimed to explore the feasibility and acceptability of a) a co-designed multi-component intervention for HPs at Aboriginal Medical Services (AMSs) in culturally-targeted pregnancy-specific smoking cessation care and b) the study design. METHODS: Using a randomised step-wedge cluster design, the Indigenous Counselling And Nicotine (ICAN) QUIT in Pregnancy Trial was evaluated across six AMSs in three Australian states...
October 30, 2018: Addictive Behaviors
Tuyet T N Nguyen, Julien Némery, Nicolas Gratiot, Emilie Strady, Viet Quoc Tran, An Truong Nguyen, Joanne Aimé, Alice Peyne
Saigon-Dongnai Rivers in Southern Vietnam is a complex lowland hydrological network of tributaries that is strongly influenced by the tidal cycles. The increasing economic, industrial and domestic developments in and around Ho Chi Minh City (HCMC) have led to serious impacts on water quality due to lack of appropriate wastewaters treatment. Drinking water production is impacted and the large aquaculture production areas may also be affected. We analyzed spatial and seasonal variability of nutrient concentrations (Phosphorus, Nitrogen and Silica) and eutrophication indicators (Organic Carbon, Chlorophyll-a and Dissolved Oxygen) based on bi-monthly monitoring during two hydrological cycles (July 2015-December 2017)...
October 26, 2018: Science of the Total Environment
Lianqing Xue, Boli Zhu, Yiping Wu, Guanghui Wei, Shumin Liao, Changbing Yang, Jing Wang, Hui Zhang, Lei Ren, Qiang Han
With large-scale developments, the Manas River Basin (MRB) is in an extreme imbalance especially in land use, thus causing a series of ecological problems. A reliable dynamic ecological risk assessment is expected to provide useful information for the economic development. Through coupling spatial Cellular Automaton-Markov (CA-Markov) model and Landsat satellite images in 2000, 2008 and 2016, we forecasted the land use maps in 2024 and 2032. Based on the ecological risk model, we evaluated the ecological risk at landscape level from 2000 to 2032...
October 30, 2018: Science of the Total Environment
Yulong Tan, Matthias Leonhard, Doris Moser, Su Ma, Berit Schneider-Stickler
Mixed fungal and bacterial biofilm associated infections of implants have been a huge challenge in health care because of the increased resistance to antimicrobials and the critical biological differences between fungi and bacteria. In this study, we evaluated the 2-aminobenzimidazole (2ABI) and curcumin (CUR) alone to inhibit planktonic cell growth, adhesion as well as single and mixed species biofilms of Candida albicans and Staphylococcus aureus on silicone. The combined effects between 2ABI and CUR on mixed species biofilm formation and pre-formed biofilm were assessed...
November 2, 2018: Colloids and Surfaces. B, Biointerfaces
Manju Singh, Ram Mohan, Sonali Mishra, Nitu Goyal, Karuna Shanker, Namita Gupta, Birendra Kumar
This article describes the study to standardize phytochemically and distinguish Swertia chirayita from that of possible substitution/adulteration using ultra performance liquid chromatography (UPLC) with photodiode array detector (PDA) and chemometric tools viz. principal component analysis (PCA) and hierarchical clustering analysis (HCA). Five ecotypes of Swertia chirayita and five possible substitutions, e.g.,Swertia bimaculata (SB), Swertia chordata (SCH), Swertia ciliata (SCL), Swertia paniculata (SP), and Halenia elliptica (HE) collected from different Indian Himalayan region...
November 1, 2018: Journal of Pharmaceutical and Biomedical Analysis
Guoyong Xie, Qiuhong Xu, Ran Li, Lu Shi, Yu Han, Yan Zhu, Gang Wu, Minjian Qin
The dried flowers and inflorescences of Buddleja officinalis Maxim are used as traditional medicines in China, and aqueous extracts of the flowers have also been used since ancient times as a yellow rice colorant at local festivals. In this study, HPLC-Q-TOF-MS/MS was used to determine the overall chemical composition of this medicine-food plant. A total of 54 compounds, including 23 flavonoids, 19 phenylethanoid glycosides, 7 alkaloids and 5 other compounds, were detected in the methanol extracts of the herb using this method...
October 22, 2018: Journal of Pharmaceutical and Biomedical Analysis
Samir A Anuj, Harsukh P Gajera, Darshna G Hirpara, Baljibhai A Golakiya
The increasing drug-resistance pathogens among gram-positive bacterial species are becoming a major health concern nowadays. Over the past few years, the bactericidal efficacy of nano‑silver against some drug-resistant gram-positive bacteria has been established, however further investigation is needed to determine whether nano‑silver could be an option for the treatment of drug-resistant gram-positive microbial infections. The purpose of the present study was to determine the bactericidal efficacy of nano‑silver with its membrane destroying property using drug-resistant Staphylococcus aureus MTCC 3160...
November 6, 2018: European Journal of Pharmaceutical Sciences
Xiaopan Li, Mengcen Qian, Genming Zhao, Chen Yang, Pingping Bao, Yichen Chen, Xiaoyan Zhou, Bei Yan, Yingying Wang, Jun Zhang, Qiao Sun
Despite the rising disease burden of colorectal cancer (CRC), CRC screening has not yet been widely introduced as a large organized program in developing countries. To facilitate better delivery of screening in these areas, we investigated the performance of a large community-based CRC screening program implemented in Shanghai Pudong New Area during the period 2013-2016. We conducted a prospective cohort study by following up the screening behavior and results of tested participants in the program. Data from the program reporting system and monthly progress reports were collected...
November 6, 2018: Preventive Medicine
Armin Azadkhah Shalmani, Mohammad Hossein Ghahremani, Fereshteh Jeivad, Amir Shadboorestan, Gholamreza Hassanzadeh, Abbas Beh-Pajooh, Mikhriy Ganbari-Erdi, Sara Kasirzadeh, Mojtaba Mojtahedzadeh, Omid Sabzevari
AIMS: Sepsis is a potentially fatal illness that can lead to impairment of multiple organs such as liver. The condition is deeply associated with oxidative stress and inflammation. Monomethyl fumarate (MMF) has manifested antioxidant and immunomodulatory properties. The aim of current study was to evaluate protective effects of MMF in sepsis-induced hepatic dysfunction. MAIN METHODS: Sepsis was induced by cecal ligation and puncture (CLP). Wistar rats were assigned to one of sham, CLP, CLP + dexamethasone (as positive control of inflammation) and CLP + MMF groups...
November 6, 2018: Life Sciences
Elizabeth V Dray, Marybeth Hall, Diana Covalschi, Ann P Cameron
OBJECTIVES: To evaluate the efficacy of urethral bulking agents for stress urinary incontinence in the setting of prior failed sling. METHODS: This is a retrospective review of patients who underwent urethral bulking agent injections for a primary complaint of stress urinary incontinence following prior failed sling surgery. The outcomes assessed were patient reported improvement, need for further interventions for incontinence and validated questionnaires. Values for questionnaires were obtained from the patient's pre-procedure visit, at the first visit following their last injection and at their most recent visit within our system...
November 6, 2018: Urology
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