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Assessment Evaluation

Henrik Odéen, Dennis L Parker
OBJECTIVES: To develop, test and evaluate improved 2D and 3D protocols for proton resonance frequency shift magnetic resonance temperature imaging (MRTI) of laser interstitial thermal therapy (LITT). The objective was to develop improved MRTI protocols in terms of temperature measurement precision and volume coverage compared to the 2D MRTI protocol currently used with a commercially available LITT system. METHODS: Four different 2D protocols and four different 3D protocols were investigated...
January 15, 2019: Lasers in Surgery and Medicine
Richard K Burt, Roumen Balabanov, Joachim Burman, Basil Sharrack, John A Snowden, Maria Carolina Oliveira, Jan Fagius, John Rose, Flavia Nelson, Amilton Antunes Barreira, Kristina Carlson, Xiaoqiang Han, Daniela Moraes, Amy Morgan, Kathleen Quigley, Kimberly Yaung, Regan Buckley, Carri Alldredge, Allison Clendenan, Michelle A Calvario, Jacquelyn Henry, Borko Jovanovic, Irene B Helenowski
Importance: Hematopoietic stem cell transplantation (HSCT) represents a potentially useful approach to slow or prevent progressive disability in relapsing-remitting multiple sclerosis (MS). Objective: To compare the effect of nonmyeloablative HSCT vs disease-modifying therapy (DMT) on disease progression. Design, Setting, and Participants: Between September 20, 2005, and July 7, 2016, a total of 110 patients with relapsing-remitting MS, at least 2 relapses while receiving DMT in the prior year, and an Expanded Disability Status Scale (EDSS; score range, 0-10 [10 = worst neurologic disability]) score of 2...
January 15, 2019: JAMA: the Journal of the American Medical Association
Jonatas Rafael de Oliveira, Polyana Graças das Figueiredo Vilela, Rosilene Batista de Aguiar Almeida, Felipe Eduardo de Oliveira, Cláudio Antonio Talge Carvalho, Samira Esteves Afonso Camargo, Antonio Olavo Cardoso Jorge, Luciane Dias de Oliveira
The use of medicinal plants can be an alternative method for the control of microorganisms responsible for human infections. This study evaluated the antimicrobial activity of Salvia officinalis Linnaeus (sage) extract on clinical samples isolated from the oral cavity and reference strains of Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus mutans, Candida albicans, Candida tropicalis, and Candida glabrata. In addition, testing assessed the cytotoxic effect of S officinalis on murine macrophages (RAW 264...
January 2019: General Dentistry
Michael D Gray, Paul C Lyon, Christophoros Mannaris, Lisa K Folkes, Michael Stratford, Leticia Campo, Daniel Y F Chung, Shaun Scott, Mark Anderson, Robert Goldin, Robert Carlisle, Feng Wu, Mark R Middleton, Fergus V Gleeson, Constantin C Coussios
Purpose To demonstrate the feasibility and safety of using focused ultrasound planning models to determine the treatment parameters needed to deliver volumetric mild hyperthermia for targeted drug delivery without real-time thermometry. Materials and Methods This study was part of the Targeted Doxorubicin, or TARDOX, phase I prospective trial of focused ultrasound-mediated, hyperthermia-triggered drug delivery to solid liver tumors ( identifier NCT02181075). Ten participants (age range, 49-68 years; average age, 60 years; four women) were treated from March 2015 to March 2017 by using a clinically approved focused ultrasound system to release doxorubicin from lyso-thermosensitive liposomes...
January 15, 2019: Radiology
Simon Lennartz, Markus Le Blanc, David Zopfs, Nils Große Hokamp, Nuran Abdullayev, Kai Roman Laukamp, Stefan Haneder, Jan Borggrefe, David Maintz, Thorsten Persigehl
Purpose To evaluate the use of spectral CT for differentiation between noncalcified benign pleural lesions and pleural carcinomatosis. Materials and Methods In this retrospective study, patients who underwent contrast agent-enhanced late venous phase spectral CT of the chest between June 1, 2016, and July 1, 2018 with histopathologic and/or imaging confirmation of noncalcified pleural lesions were evaluated. Conventional images, iodine overlay (IO) images, and virtual monoenergetic images at 40 keV (hereafter, VMI40keV ) were reconstructed from contrast-enhanced spectral chest CT...
January 15, 2019: Radiology
Quang Ngoc Dong, Masaaki Karino, Takashi Koike, Taichi Ide, Satoe Okuma, Ichiro Kaneko, Rie Osako, Takahiro Kanno
PURPOSE: We investigated the feasibility of isolated medial orbital wall fracture reconstruction using an unsintered hydroxyapatite particles/poly L-lactide (u-HA/PLLA) sheet implant with the assistance of intraoperative navigation via the transcaruncular approach. PATIENTS AND METHODS: Ten consecutive patients (5 males and 5 females; mean age, 57.5 years) were included based on the clinical and imaging criteria. All patients underwent surgical treatment of the isolated medial orbital wall fracture using transcaruncular incision and the u-HA/PLLA implant under navigation...
January 15, 2019: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
Uğur Gökçelli, Utku Kürşat Ercan, Enver İlhan, Asuman Argon, Elif Çukur, Orhan Üreyen
PURPOSES: Formation of peritoneal adhesions is a common consequence of abdominopelvic surgeries and remarkably increases the mortality and morbidity. Moreover, peritoneal adhesions linked to chronic abdominopelvic pain and infertility in women. Various attempts for prevention of peritoneal adhesions were reported. However, these methods either remain insufficient to prevent formation of peritoneal adhesions or carry some practical limitations and thus, there is a need for novel techniques that could effectively decrease the formation of peritoneal adhesions...
January 15, 2019: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
Joseph F McGuire, Patricia Z Tan, John Piacentini
This report examined the nature of obsessive-compulsive disorder (OCD) symptoms nominated for treatment and investigate improvement in OCD symptom dimensions. Youth with OCD (N = 71) participated in a clinical trial that compared exposure-based cognitive behavior therapy (CBT) to psychoeducation plus relaxation training (PRT). Participants completed a baseline assessment to characterize OCD severity. Next, parents and youth collaboratively developed an OCD symptom treatment hierarchy. Afterward, these symptoms were independently reassessed at each session by youth and parents...
January 15, 2019: Journal of Clinical Child and Adolescent Psychology
Gregory Hansen, Joshua Hochman, Meghan Garner, Jeffrey Dmytrowich, Tanya Holt
BACKGROUND: Delivery of noninvasive ventilation commonly occurs in the pediatric intensive care unit (PICU). With the advent of high flow nasal cannula (HFNC), patients with respiratory distress may be rescued on the ward without a PICU admission. We evaluated our ward HFNC algorithm to determine its safety profile and independent predictors for non-responders, defined as requiring a subsequent PICU admission. METHODS: A retrospective chart review for patients <17 years of age admitted with respiratory distress between 2016-17...
January 15, 2019: Pediatrics International: Official Journal of the Japan Pediatric Society
Ivo Genev, Gardner Yost, Mary Gregory, Kayéromi Gomez, Patroklos Pappas, Antone Tatooles, Geetha Bhat
BACKGROUND: Left ventricular assist device (LVAD) implantation for advanced heart failure is known to improve survival, functional capacity, and quality of life. Most patients implanted with LVADs suffer from moderate to severe malnutrition and deconditioning due to their advanced disease. The Mini Nutritional Assessment (MNA) and the short form of the survey (MNA-SF) are 2 well-validated clinical tools, previously used to assess patient nutrition status in numerous conditions. Earlier work has demonstrated that low nutrition scores can independently predict mortality in the LVAD population...
January 15, 2019: Nutrition in Clinical Practice
Diana M Solomon, Elizabeth Zorzanello Emery, Haley L Kavelak, Laura Pontiggia, James M Hollands, Angela L Bingham
BACKGROUND: The American Society for Parenteral and Enteral Nutrition (ASPEN) parenteral nutrition (PN) safety consensus recommendations advise a comprehensive education program and competency assessment for all healthcare professionals involved in the care of patients receiving PN. The ASPEN-model papers provide guidance for designing PN competencies for prescribers, pharmacists, and pharmacy technicians. The purpose of this research was to evaluate the impact of a comprehensive educational program that aligns with the ASPEN model on PN competency, attitudes, and perceptions in a multidisciplinary healthcare professional audience...
January 15, 2019: Nutrition in Clinical Practice
Safeena Kulsum, Nalini Raju, Nisheena Raghavan, Ravindra Dr, Anupam Sharma, Alka Mehta, Moni A Kuriakose, Amritha Suresh
Understanding the cellular interactions during oral carcinogenesis has the potential to identify novel prognostic and therapeutic targets. This study aimed at investigating the cancer stem cell (CSCs)-fibroblast niche interactions using in-vitro dysplastic cell line models developed from different stages of 4NQO-induced oral carcinogenic mice model. The spontaneously transformed epithelial cells (DysMSCTR6, 14 and 16) were developed from three time points (mild/moderate/severe), while 2 fibroblast cell lines (FibroMSCTR12, 16) were developed from moderate and severe dysplastic tissue...
January 15, 2019: Molecular Carcinogenesis
Litong Fan, Jiaqing Chen, Yanmeng Tao, Boon Chin Heng, Jiakuo Yu, Zheng Yang, Zigang Ge
Transforming growth factor beta (TGF-β) is commonly utilized in chondrogenic differentiation protocols, but this often results in incomplete maturation of the derived chondrocytes. Gene expression analysis, quantitation of sulfated glycosaminoglycan and collagen, and histological staining were performed to assess the effects of ghrelin. The signaling pathways involved were investigated with inhibitors or targeted by shRNAs. Joint cavity delivery of TGF-β with or without ghrelin, within a rat cartilage defect model was performed to evaluate the in vivo effects of ghrelin...
January 15, 2019: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Elizabeth R Mueller, Rob van Maanen, Christopher Chapple, Paul Abrams, Sender Herschorn, Dudley Robinson, Matthias Stoelzel, Sang J Yoon, Salman Al-Shukri, Tomasz Rechberger, Christian Gratzke
AIMS: SYNERGY II was a 12-month phase III trial in patients with overactive bladder (OAB) symptoms that investigated the safety and efficacy of the combination of mirabegron and solifenacin in comparison with each monotherapy. This analysis evaluated the trial findings using four age subgroups (<65, ≥65, <75, and ≥75 years). METHODS: Eligible patients were ≥18 years with symptoms of "wet" OAB (urinary frequency and urgency with incontinence) for ≥3 months...
January 15, 2019: Neurourology and Urodynamics
Danielle McClanahan, Andrew Yeh, Brian Firek, Stacey Zettle, Matthew Rogers, Richard Cheek, Michelle V L Nguyen, Christopher P Gayer, Stacy G Wendell, Steven J Mullett, Michael J Morowitz
BACKGROUND: Dietary intake sharply impacts the structure and function of the gut microbiota, which is important for childhood health. However, little is known about the microbiota of children who cannot eat by mouth. Standard enteral formulas for supplemental nutrition are low in fiber and high in processed sugars and are commonly associated with gastrointestinal side effects. In this pilot study, we examined the effects of plant-based enteral nutrition (PBEN) upon the gut bacteria of chronically ill children...
January 15, 2019: JPEN. Journal of Parenteral and Enteral Nutrition
Lawrence LeBeau, Christine Morgan, Deborah Heath, Vanessa K Pazdernik
Context: The Mini-Clinical Evaluation Exercise (Mini-CEX) is one example of a direct observation tool used for workplace-based skills assessment. The Mini-CEX has been validated as a useful formative evaluation tool in graduate medical education. However, no Mini-CEX has been reported in the literature that specifically assesses the osteopathic manipulative medicine (OMM) skills of family medicine residents. Therefore, the authors created and studied an OMM Mini-CEX to fill this skills assessment gap...
January 15, 2019: Journal of the American Osteopathic Association
Hülya Çizmeci, Ayça Çiprut
OBJECTIVES: This study aims to evaluate the reading and writing abilities of students with cochlear implants and compare their results with those of their normal-hearing peers. The effect of age at implantation and duration of cochlear implant use were analyzed in relation to the subjects' reading and writing skills development. MATERIALS AND METHODS: The study included 20 students who underwent cochlear implantation and 20 students with normal hearing, who were enrolled during their 6th to 8th grades...
December 2018: Journal of International Advanced Otology
Wilfried Lebon, Jacques Guillot, Maria-Jesús Álvarez, José Antonio Bazaga, Marie-Laure Cortes-Dubly, Pascal Dumont, Marianne Eberhardt, Héctor Gómez, Olivier Pennant, Noémie Siméon, Frederic Beugnet, Lénaïg Halos
In the past decade, canine thelaziosis due to Thelazia callipaeda has been diagnosed in an increasing number of European countries, with endemic areas being identified. A multi-center field trial was conducted in endemic areas in France and Spain to evaluate the efficacy of monthly administrations of the oral milbemycin oxime/afoxolaner combination (NexGard Spectra® ) for the prevention of T. callipaeda infection in at-risk dogs. A total of 79 dogs negative for T. callipaeda and with a clinical history of eyeworm infection in the past two years completed the study...
2019: Parasite: Journal de la Société Française de Parasitologie
Petri Mankinen, Ville Vihervaara, Saku Torvinen, Janne Martikainen, Erkki Soini
AIM: To estimate the drug administration, travelling, and productivity costs associated with infusion or subcutaneous proteasome inhibitor (PI) treatments (specifically carfilzomib and bortezomib) for multiple myeloma (MM) patients in Finland. MATERIALS AND METHODS: Price tariffs of Finnish hospital districts are used as the basis of invoicing sent to health care service payers. A review of these price tariff lists was conducted and obtained data analyzed to estimate the mean unit cost of PI administration visit...
January 15, 2019: Journal of Medical Economics
Małgorzata Frankowska, Joanna Miszkiel, Lucyna Pomierny-Chamioło, Bartosz Pomierny, Giuseppe Giannotti, Agata Suder, Małgorzata Filip
BACKGROUND: Environmental conditions have an important function in substance use disorder, increasing or decreasing the risks of relapse. Several studies strongly support the role of the dopamine D2 -like and metabotropic glutamate type 5 receptors in maladaptive neurobiological responses to cocaine reward and relapse. AIMS: The present study employed cocaine self-administration with yoked-triad procedure in rats to explore whether drug abstinence in different housing conditions affects the drug-seeking behaviour and the dopamine D2 -like and metabotropic glutamate type 5 receptor density and affinity in several regions of the animal brain...
January 15, 2019: Journal of Psychopharmacology
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