Xin Dong, Ruijia Wen, Yuanyuan Xiong, Xiaotong Jia, Xiwen Zhang, Xin Li, Liangyou Zhang, Zhibin Li, Shu Zhang, Yanna Yu, Qiang Li, Xingbo Wu, Haitao Tu, Zixin Chen, Shaoxiang Xian, Lingjun Wang, Chao Wang, Lianqun Jia, Junyan Wang, Gangyi Chen
Cardiorenal syndrome type 4 (CRS4), a progressive deterioration of cardiac function secondary to chronic kidney disease (CKD), is a leading cause of death in patients with CKD. In this study, we aimed to investigate the cardioprotective effect of emodin on CRS4. C57BL/6 mice with 5/6 nephrectomy and HL-1 cells stimulated with 5% CKD mouse serum were used for in vivo and in vitro experiments. To assess the cardioprotective potential of emodin, we employed a comprehensive array of methodologies, including echocardiography, tissue staining, immunofluorescence staining, biochemical detection, flow cytometry, real-time quantitative PCR, and western blot analysis...
January 10, 2024: Phytotherapy Research: PTR