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Echocardiography CKD

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https://www.readbyqxmd.com/read/30079760/contribution-of-volume-overload-to-progression-of-cardiovascular-diseases-in-rat-model-of-chronic-kidney-disease
#1
Manal Moustafa Mahmoud, Asmaa Shamseldeen, Laila Ahmed Rashed, Amal Elham Fares, Ashraf Shamaa, Doaa Mostafa Gharib
Volume overload, the common phenomenon in patients with chronic kidney disease is associated with cardiovascular risk factors.Howeverits contribution to development of adverse cardiovascular outcomes in those patients is not fully studied.Thus, the presentworkaimed to study the effect of highsalt-induced volumeoverloadin a rat model of chronic kidney disease on cardiac functions and geometry. Thirty adult male Sprague-Dawley rats were randomly divided to a sham operation anduninephrectomy, thenwere subjected to either a normal-salt (0...
August 4, 2018: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/30041199/strategy-for-prevention-of-left-ventricular-remodeling-in-predialysis-and-dialysis-patients
#2
Hiroaki Io, Yusuke Suzuki
BACKGROUND: Currently, left ventricular (LV) hypertrophy and dysfunction are considered the strongest predictors of cardiovascular mortality in chronic kidney disease (CKD) patients. We investigated the factors associated with elevated LV mass index (LVMI) using echocardiography and assessed the strategies used to treat CKD (stages 1-5D) patients. SUMMARY: In study 1, we prospectively determined correlations among biochemical values, physical specimens, and LVMI using echocardiography in hemodialysis (HD) and peritoneal dialysis (PD) patients (stage 5D)...
2018: Contributions to Nephrology
https://www.readbyqxmd.com/read/30021207/-cxcl12-in-patients-with-chronic-kidney-disease-and-healthy-controls-relationships-to-ambulatory-24-hour-blood-pressure-and-echocardiographic-measures
#3
Dominika Klimczak-Tomaniak, Tomasz Pilecki, Dorota Żochowska, Damian Sieńko, Maciej Janiszewski, Leszek Pączek, Marek Kuch
BACKGROUND/AIMS: Chronic kidney disease is a pro-inflammatory condition where the interplay between different regulatory pathways and immune cells mediates an unfavorable remodeling of the vascular wall and myocardial hypertrophy. These mechanisms include the action of CXCL12. The aim of this study is to evaluate the association between serum CXCL12 with left ventricular hypertrophy (LVH) and blood pressure control in chronic kidney disease (CKD) patients. METHODS: This single-center observational study involved 90 stable CKD stage 1-5 patients (including 33 renal transplant recipients) and 25 healthy age- and sex-matched control subjects...
2018: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29996910/echocardiographic-parameters-and-renal-outcomes-in-patients-with-preserved-renal-function-and-mild-moderate-ckd
#4
Thomas A Mavrakanas, Aisha Khattak, Karandeep Singh, David M Charytan
BACKGROUND: Echocardiographic characteristics across the spectrum of chronic kidney disease (CKD) have not been well described. We assessed the echocardiographic characteristics of patients with preserved renal function and mild or moderate CKD referred for echocardiography and determined whether echocardiographic parameters of left ventricular (LV) and right ventricular (RV) structure and function were associated with changes in renal function and mortality. METHODS: This retrospective cohort study enrolled all adult patients who had at least one trans-thoracic echocardiography between 2004 and 2014 in our institution...
July 11, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29984555/uremia-increases-qrs-duration-after-%C3%AE-adrenergic-stimulation-in-mice
#5
Morten B Thomsen, Morten S Nielsen, Annemarie Aarup, Line S Bisgaard, Tanja X Pedersen
Chronic kidney disease (CKD) and uremia increase the risk of heart disease and sudden cardiac death. Coronary artery disease can only partly account for this. The remaining mechanistic links between CKD and sudden death are elusive, but may involve cardiac arrhythmias. For the present study, we hypothesized that a thorough electrophysiological study in mice with CKD would provide us valuable information that could aid in the identification of additional underlying causes of sudden cardiac death in patients with kidney disease...
July 2018: Physiological Reports
https://www.readbyqxmd.com/read/29981797/mineralocorticoid-receptor-antagonism-improves-diastolic-dysfunction-in-chronic-kidney-disease-in-mice
#6
Benjamin Bonnard, Marie Pieronne-Deperrois, Zoubir Djerada, Soumaya Elmoghrabi, Peter Kolkhof, Antoine Ouvrard-Pascaud, Paul Mulder, Frédéric Jaisser, Smail Messaoudi
Managing the cardiovascular complications of renal failure is a major therapeutic challenge in clinical practice. Mineralocorticoid Receptor (MR) blockade is a highly effective strategy for the management of heart failure, but the use of MR antagonists (MRA) is limited by their side effects rendering them contraindicated in patients with renal failure. Finerenone is a new non-steroidal MRA that shows fewer hyperkaliaemic events than the traditional steroidal MRAs and could therefore represent an alternative to these molecules in patients with damaged kidney function...
July 6, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29969785/adenine-induced-chronic-renal-failure-in-rats-a-model-of-chronic-renocardiac-syndrome-with-left-ventricular-diastolic-dysfunction-but-preserved-ejection-fraction
#7
Pavlos Kashioulis, Jaana Lundgren, Emman Shubbar, Lisa Nguy, Aso Saeed, Cecilia Wallentin Guron, Gregor Guron
BACKGROUND/AIMS: Cardiovascular disease is the major cause of death in patients with chronic kidney disease (CKD). Rats with adenine-induced chronic renal failure (ACRF) develop severe renal insufficiency and metabolic abnormalities that closely resemble those in patients with uremia. The aim of the present study was to determine left ventricular (LV) morphology and function in rats with ACRF. METHODS: Male Sprague-Dawley rats received either chow containing adenine or were pair-fed an identical diet without adenine (controls, C)...
July 3, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29958233/nondipping-pattern-on-24-h-ambulatory-blood-pressure-monitoring-is-associated-with-left-ventricular-hypertrophy-in-chronic-kidney-disease
#8
David A Jaques, Hajo Müller, Chantal Martinez, Sophie De Seigneux, Pierre-Yves Martin, Belen Ponte, Patrick Saudan
BACKGROUND: Few studies have assessed the role of 24-h ambulatory blood pressure monitoring (ABPM) in adults with nondialysis chronic kidney disease (CKD). We examined the potential determinants of left ventricular hypertrophy (LVH) and mass index (LVMI) in this population. PARTICIPANTS AND METHODS: We carried out a cross-sectional study on 69 stage 3b-5 CKD adults who had ABPM and transthoracic echocardiography performed simultaneously. Hypertension (HT) was defined as 24 h blood pressure (BP) of at least 130/80 mmHg...
June 28, 2018: Blood Pressure Monitoring
https://www.readbyqxmd.com/read/29948637/the-effect-of-different-treatment-strategies-on-left-ventricular-myocardial-deformation-parameters-in-patients-with-chronic-renal-failure
#9
Ufuk Yildirim, Okan Gulel, Alay Eksi, Melda Dilek, Sabri Demircan, Mahmut Sahin
The aim of this study was to compare left ventricular (LV) functions by speckle tracking echocardiography (STE) in chronic kidney disease (CKD) patients in various stages and under different renal replacement treatments in order to evaluate possible differences between them. This prospective study included 150 patients with CKD. Renal transplantation patients with glomerular filtration rate greater than 60 ml/min/1.73 m2 , patients receiving hemodialysis three times a week, and patients in the predialysis stage with glomerular filtration rate less than 30 ml/dk/1...
June 9, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29948444/effect-of-essential-amino-acid-%C3%B0%C2%BAetoanalogues-and-protein-restriction-diet-on-morphogenetic-proteins-fgf-23-and-%C3%B0-lotho-in-3b-4-stages-chronic-%C3%B0%C2%BAidney-disease-patients-a-randomized-pilot-study
#10
Lyudmila Milovanova, Victor Fomin, Sergey Moiseev, Marina Taranova, Yury Milovanov, Lidia Lysenko Kozlovskaya, Vasiliy Kozlov, Elena Kozevnikova, Svetlana Milovanova, Marina Lebedeva, Vladimir Reshetnikov
BACKGROUND: A low protein diet (LPD) with essential amino acid ketoanalogue supplementation (KA) may contribute in improving of chronic kidney disease (CKD), while the exact mechanisms of KA's effect are not established yet. We have conducted a prospective, randomized, controlled comparative study of LPD + KA and LPD alone in relation to serum Klotho, FGF-23 levels in CKD patients. METHODS: 79 non-diabetic CKD 3b-4 stage patients, compliant with LPD diet (0...
June 11, 2018: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29940595/assessment-of-peritoneal-membrane-arteriolar-structure-in-conjunction-with-traditional-cardiovascular-system-evaluation-in-chronic-kidney-disease-ckd-stage-5-patients
#11
Rafal Donderski, Paweł Stróżecki, Beata Sulikowska, Magdalena Grajewska, Ryszard Trafny, Magdalena Bodnar, Andrzej Marszałek, Anna Stefańska, Joanna Siódmiak, Grażyna Odrowąż-Sypniewska, Jacek Manitius
BACKGROUND/AIMS: Cardiovascular complications are responsible for increased mortality and morbidity in chronic kidney disease (CKD) patients. Functional and structural changes of peritoneal membrane are reported in CKD patients both on conservative treatment and on renal replacement therapy (RRT). The aim of the study was to assess the structure of peritoneal membrane small arteries (precapillary arterioles) in diabetic and non-diabetic CKD stage 5 patients before initiation of peritoneal dialysis (PD) and evaluate its relationship with heart and large arteries abnormalities and with selected biochemical parameters...
2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29889834/pathological-presentation-of-cardiac-mitochondria-in-a-rat-model-for-chronic-kidney-disease
#12
Einat Bigelman, Lena Cohen, Genya Aharon-Hananel, Ran Levy, Zach Rozenbaum, Ann Saada, Gad Keren, Michal Entin-Meer
BACKGROUND: Mitochondria hold crucial importance in organs with high energy demand especially the heart. We investigated whether chronic kidney disease (CKD), which eventually culminates in cardiorenal syndrome, could affect cardiac mitochondria and assessed the potential involvement of angiotensin II (AngII) in the process. METHODS: Male Lewis rats underwent 5/6 nephrectomy allowing CKD development for eight months or for eleven weeks. Short-term CKD rats were administered with AngII receptor blocker (ARB)...
2018: PloS One
https://www.readbyqxmd.com/read/29861563/a-prospective-study-of-pulmonary-hypertension-in-patients-with-chronic-kidney-disease-a-new-and-pernicious-complication
#13
H Suresh, B S Arun, V Moger, P B Vijayalaxmi, K T K Murali Mohan
Pulmonary hypertension (PH) is a recently recognized complication of chronic kidney disease (CKD), especially in end-stage renal disease. It has prevalence estimates of 30%-50% and is an independent predictor of increased mortality in CKD patients. The aim of this study is to analyze the prevalence of PH in patients with CKD, its severity in different stages of CKD, and risk factors for it. One hundred and eight patients with CKD treated at Karnataka Institute of Medical Sciences, Hubli, Karnataka, between January 1, 2014, and June 30, 2015, were selected...
March 2018: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/29781842/application-of-echocardiographic-data-in-patients-with-chronic-kidney-disease
#14
Ruth F Dubin
PURPOSE OF REVIEW: Patients with chronic kidney disease (CKD) are at a high risk for cardiovascular events and mortality, particularly heart failure. Echocardiography is the most commonly used diagnostic imaging modality for heart failure. The purpose of this review is to summarize recent literature that demonstrates how echocardiography may be used to define cardiac structure and function in the CKD population and to identify echocardiographic abnormalities that have utility in predicting clinical outcomes in this population...
July 2018: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/29779029/low-plasma-hydrogen-sulfide-is-associated-with-impaired-renal-function-and-cardiac-dysfunction
#15
Qing Kuang, Ning Xue, Jing Chen, Ziyan Shen, Xiaomeng Cui, Yi Fang, Xiaoqiang Ding
BACKGROUND: Chronic kidney disease (CKD) has been proposed to associate with decreased hydrogen sulfide (H2S) level. Nevertheless, the role of H2S in the pathogenesis of CKD has not been fully investigated. Our study aimed to investigate the plasma level of endogenous H2S in patients with different stages of CKD, and to identify the role of H2S in the progression of CKD and its relationship with cardiovascular diseases. METHODS: A total of 157 non-dialysis CKD patients were recruited in our study, with 37 age- and sex-matched healthy individuals as control...
2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29775443/-b-type-natriuretic-peptide-as-a-marker-of-cardiac-dysfunction-in-children-with-chronic-kidney-disease
#16
Tomasz Drożdż, Przemko Kwinta, Zbigniew Kordon, Krystyna Sztefko, Andrzej Rudziński, Katarzyna Zachwieja, Monika Miklaszewska, Danuta Czarnecka, Dorota Drożdż
Left ventricular hypertrophy is the most common organ damage in children with chronic kidney disease (CKD). AIM: The aim of the study was to assess the usefulness of B-type natriuretic peptide (BNP) as a marker of heart injury in children with CKD. MATERIALS AND METHODS: We included 66 children (41 boys and 25 girls) aged 0.7 to 18.6 (median 11.6) years with CKD stage 1-5. The concentrations of urea, creatinine, cystatin C and BNP in blood serum were assessed, and the estimated glomerular filtration rate (eGFR) was calculated from the Schwartz and Filler formulas...
April 23, 2018: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29750229/left-ventricular-twist-before-and-after-haemodialysis-an-analysis-using-speckle-tracking-echocardiography
#17
Anthony Yip, Saraladevi Naicker, Ferande Peters, Elena Libhaber, Nirvathi Maharaj, Mduduzi Mashabane, Mohammed Rafique Essop
BACKGROUND: The most commonly used parameter of cardiac function in the chronic kidney disease (CKD) patient is ejection fraction (EF), using transthoracic echocardiography (TTE). EF is a highly load-dependent measurement, which varies considerably in CKD patients undergoing haemodialysis. The aim of this pilot study was to evaluate a novel measure of myocardial function, left ventricular twist, which is defined as the 'wringing action of the heart', using speckletracking echocardiography in CKD patients before and after haemodialysis...
April 20, 2018: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/29734153/clinical-impact-of-left-ventricular-diastolic-dysfunction-in-chronic-kidney-disease
#18
Tetsuya Ogawa, Kosaku Nitta
Left ventricular diastolic dysfunction (LVDD) frequently occurs in chronic kidney disease (CKD) and is associated with heart failure and higher mortality. LVDD is observed in patients with early stages of CKD and is associated with cardiovascular events, in patients undergoing incident hemodialysis in the absence of systolic function. The pathogenesis of CKD includes abnormal ventricular filling in diastole and a higher LV filling pressure (LVFP) because of LV hypertrophy (LVH), in addition to myocardial interstitial fibrosis...
2018: Contributions to Nephrology
https://www.readbyqxmd.com/read/29684593/renal-function-n-terminal-pro-b-type-natriuretic-peptide-propeptide-big-endothelin-and-patients-with-heart-failure-and-preserved-ejection-fraction
#19
Ingrid Gergei, Bernhard K Krämer, Hubert Scharnagl, Tatjana Stojakovic, Winfried März
Renal dysfunction may limit the clinical application of NT-proBNP in the diagnosis of heart failure. In general practice, where echocardiography is not readily available, a biomarker for the diagnosis of a heart failure with preserved ejection fraction (HFpEF) would be useful. Since cardiac diseases frequently coincide with renal disease, there is a high need of valid risk stratification methods in patients affected with both. We therefore examined NT-proBNP and another biomarker, Big-Endothelin-1, as a marker of HFpEF in patients with CKD...
April 21, 2018: Peptides
https://www.readbyqxmd.com/read/29682152/thrombomodulin-as-a-new-marker-of-endothelial-dysfunction-in-chronic-kidney-disease-in-children
#20
Dorota Drożdż, Monika Łątka, Tomasz Drożdż, Krystyna Sztefko, Przemko Kwinta
Endothelial dysfunction (ED) and oxidative stress are potential new pathomechanisms of cardiovascular diseases in patients with chronic kidney disease (CKD). The aim of the study was to assess the association between endothelial dysfunction, oxidative stress biomarkers, and cardiovascular risk factors in children with CKD. Serum oxidized LDL (oxLDL), protein carbonyl group, urea, creatinine, cystatin C, thrombomodulin, asymmetric dimethylarginine (ADMA), von Willebrand factor, brain natriuretic peptide (BNP), lipids, high sensitivity C-reactive protein, intercellular adhesion molecule-1 levels, and albuminuria were measured...
2018: Oxidative Medicine and Cellular Longevity
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