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Echocardiography CKD

Zhuo Xu, Hui-Ping Gu, Yang Gu, Wei Sun, Kun Yu, Xi-Wen Zhang, Xiang-Qing Kong
Objective: To study the coronary microvascular function in older patients with heart failure with preserved ejection fraction (HFpEF) using an invasive pressure-temperature sensor guidewire. Methods: Patients undergoing echocardiography and cardiac catheterization examinations for exertional dyspnea and a positive stress test were retrospectively enrolled from January 2014 to November 2017, and were allocated into the control group or HFpEF group. The HFpEF group was secondary divided into two groups according to the age of 65...
November 2018: Journal of Geriatric Cardiology: JGC
A Savarese, M Probo, C Locatelli, A L Gazzonis, S A Zanzani, G Traini, T Vitiello, P G Brambilla
In humans, iron deficiency represents a relevant occurrence in heart failure (HF), with or without anaemia, and is associated with the worst outcome. Moreover, chronic kidney disease (CKD) is a well-known comorbidity of HF and is strongly associated with the risk of developing anaemia. The most common cause of HF in dogs is myxomatous mitral valve disease (MMVD). To the best of our knowledge, no studies have examined the iron status in dogs with HF, with and without CKD. The aim of this retrospective study was to evaluate the iron status in dogs affected by MMVD and how strong is the relation with HF...
September 2018: Polish Journal of Veterinary Sciences
Eglė Tamulėnaitė, Rūta Žvirblytė, Rūta Ereminienė, Edita Žiginskienė, Eglė Ereminienė
Background and objectives : Chronic kidney disease (CKD) increases the risk of cardiovascular diseases even in its early stages and is associated with structural and functional cardiac abnormalities. The aim of this study was to use speckle-tracking echocardiography (STE) to evaluate left and right ventricle mechanics and function, markers of subclinical dysfunction in patients with end-stage renal disease (ESRD) undergoing haemodialysis. Methods : Patients with ESRD undergoing regular haemodialysis and with preserved left ventricle (LV) ejection fraction (EF) ( n = 38) were enrolled in this retrospective study...
November 13, 2018: Medicina
Il Young Kim, June Hyun Kim, Min Jeong Kim, Dong Won Lee, Cheol Gu Hwang, Miyeun Han, Harin Rhee, Sang Heon Song, Eun Young Seong, Soo Bong Lee
BACKGROUND: Cardiovascular disease (CVD) is a leading cause of death in patients with chronic kidney disease (CKD). Left ventricular hypertrophy (LVH) and left ventricular diastolic dysfunction (LVDD) are known as predictors of CVD in these patients. Neutrophil gelatinase-associated lipocalin (NGAL) is a biomarker of acute kidney injury. Recently, elevated NGAL levels have been reported in patients with CVD. This study aimed to evaluate the association between plasma NGAL levels and LVH/LVDD in patients with CKD...
2018: PloS One
Yunan Zhou, Matthias Hellberg, Evangelia Kouidi, Asterios Deligiannis, Peter Höglund, Naomi Clyne
BACKGROUND: Abdominal aortic calcification (AAC) is an established risk factor for cardiovascular events in patients with chronic kidney disease (CKD). We hypothesized that AAC is associated with a decline in glomerular filtration rate (GFR) as well as with some other cardiovascular risk factors. MATERIALS AND METHODS: This is a cross-sectional analysis of baseline data from a randomized controlled clinical trial (RENEXC). A total of 151 patients (aged 66 ± 14 years) with an average measured GFR (mGFR) of 22...
October 12, 2018: Clinical Nephrology
Shun Kizawa, Takahide Ito, Kanako Akamatsu, Noboru Ichihara, Shimpei Nogi, Masatoshi Miyamura, Yumiko Kanzaki, Koichi Sohmiya, Masaaki Hoshiga
Patients with chronic kidney disease (CKD) experiencing atrial arrhythmia are hypothesized to have elevated CHADS2 and CHA2 DS2 -VASc scores, thereby predisposed to left atrial (LA) thrombus formation and subsequent thromboembolism. We examined possible association of LA thrombogenic milieu (TM) with CKD in patients with nonvalvular atrial fibrillation. A total of 581 patients (181 women; mean age, 67 years) who underwent transesophageal echocardiography were examined. Patients were divided into 4 groups based on the estimated glomerular filtration rate (eGFR) (ml/min/1...
September 13, 2018: American Journal of Cardiology
Noman Ali, Smriti Saraf, Dominik Schlosshan, Michael Cunnington, Christopher J Malkin, Daniel J Blackman
Trans-catheter aortic valve implantation (TAVI) has become an established treatment for inoperable and high-surgical risk patients with severe, symptomatic aortic stenosis (AS). Post-procedural acute kidney injury (AKI) is a frequent complication following TAVI and is associated with increased mortality. Patients with pre-existing chronic renal impairment are at particularly high risk. The etiology of post-TAVI AKI is multi-factorial, but the principal procedural issues are contrast-induced nephropathy, and renal hypoperfusion secondary to intra-procedural hypotension...
October 2018: Journal of Cardiology Cases
Anna Chuda, Joanna Berner, Małgorzata Lelonek
BACKGROUND: Care for patients with heart failure (HF) in Poland requires improvement. OBJECTIVES: The aim of this study was to define the journey of a HF patient, taking into account the specialization of the hospital ward and further highly specialized outpatient care. MATERIAL AND METHODS: Using the medical system CliniNET® we analyzed 214 consecutive patients hospitalized due to HF (ICD-10: I50) in the period from September 1, 2015, to December 31, 2015, and also the data from post-discharge outpatient care in a 3-month period...
October 2, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Giovanni Fazio, Ilaria Dentamaro, Rosanna Gambacurta, Pasquale Alcamo, Paolo Colonna
BACKGROUND AND OBJECTIVE: Patients with atrial fibrillation (AF) and advanced chronic kidney disease (CKD) are at high risk of adverse events and are complicated to manage. There is little evidence on the effects of non-vitamin K oral anticoagulants in patients with severe CKD. Preliminary data in patients taking edoxaban whose creatinine clearance fell below 30 mL/min showed a low risk of stroke and major bleeding. The aim of our study is to test the safety of edoxaban 30 mg/day in patients with severe renal impairment with an estimated glomerular filtration rate (eGFR) of 15-29 mL/min...
November 2018: Clinical Drug Investigation
Mattia Arrigo, Pietro E Cippà, Alexandre Mebazaa
PURPOSE OF THE REVIEW: To summarize current advances in the understanding and management of heart failure (HF) in patients with advanced chronic kidney disease (CKD). RECENT FINDINGS: Diagnosis of HF and treatment of congestion are crucial in the management of patients with advanced CKD to reduce symptoms, preserve organ function, and improve outcomes. Echocardiography and cardiovascular biomarkers may help to differentiate cardiac from non-cardiac components of overhydration...
October 2018: Current Heart Failure Reports
Manal Moustafa Mahmoud, Asmaa Shamseldeen, Laila Ahmed Rashed, Amal Elham Fares, Ashraf Shamaa, Doaa Mostafa Gharib
Volume overload, the common phenomenon in patients with chronic kidney disease is associated with cardiovascular risk factors.Howeverits contribution to development of adverse cardiovascular outcomes in those patients is not fully studied.Thus, the presentworkaimed to study the effect of highsalt-induced volumeoverloadin a rat model of chronic kidney disease on cardiac functions and geometry. Thirty adult male Sprague-Dawley rats were randomly divided to a sham operation anduninephrectomy, thenwere subjected to either a normal-salt (0...
August 4, 2018: Canadian Journal of Physiology and Pharmacology
Hiroaki Io, Yusuke Suzuki
BACKGROUND: Currently, left ventricular (LV) hypertrophy and dysfunction are considered the strongest predictors of cardiovascular mortality in chronic kidney disease (CKD) patients. We investigated the factors associated with elevated LV mass index (LVMI) using echocardiography and assessed the strategies used to treat CKD (stages 1-5D) patients. SUMMARY: In study 1, we prospectively determined correlations among biochemical values, physical specimens, and LVMI using echocardiography in hemodialysis (HD) and peritoneal dialysis (PD) patients (stage 5D)...
2018: Contributions to Nephrology
Dominika Klimczak-Tomaniak, Tomasz Pilecki, Dorota Żochowska, Damian Sieńko, Maciej Janiszewski, Leszek Pączek, Marek Kuch
BACKGROUND/AIMS: Chronic kidney disease is a pro-inflammatory condition where the interplay between different regulatory pathways and immune cells mediates an unfavorable remodeling of the vascular wall and myocardial hypertrophy. These mechanisms include the action of CXCL12. The aim of this study is to evaluate the association between serum CXCL12 with left ventricular hypertrophy (LVH) and blood pressure control in chronic kidney disease (CKD) patients. METHODS: This single-center observational study involved 90 stable CKD stage 1-5 patients (including 33 renal transplant recipients) and 25 healthy age- and sex-matched control subjects...
2018: Cardiorenal Medicine
Thomas A Mavrakanas, Aisha Khattak, Karandeep Singh, David M Charytan
BACKGROUND: Echocardiographic characteristics across the spectrum of chronic kidney disease (CKD) have not been well described. We assessed the echocardiographic characteristics of patients with preserved renal function and mild or moderate CKD referred for echocardiography and determined whether echocardiographic parameters of left ventricular (LV) and right ventricular (RV) structure and function were associated with changes in renal function and mortality. METHODS: This retrospective cohort study enrolled all adult patients who had at least one trans-thoracic echocardiography between 2004 and 2014 in our institution...
July 11, 2018: BMC Nephrology
Morten B Thomsen, Morten S Nielsen, Annemarie Aarup, Line S Bisgaard, Tanja X Pedersen
Chronic kidney disease (CKD) and uremia increase the risk of heart disease and sudden cardiac death. Coronary artery disease can only partly account for this. The remaining mechanistic links between CKD and sudden death are elusive, but may involve cardiac arrhythmias. For the present study, we hypothesized that a thorough electrophysiological study in mice with CKD would provide us valuable information that could aid in the identification of additional underlying causes of sudden cardiac death in patients with kidney disease...
July 2018: Physiological Reports
Benjamin Bonnard, Marie Pieronne-Deperrois, Zoubir Djerada, Soumaya Elmoghrabi, Peter Kolkhof, Antoine Ouvrard-Pascaud, Paul Mulder, Frédéric Jaisser, Smail Messaoudi
Managing the cardiovascular complications of renal failure is a major therapeutic challenge in clinical practice. Mineralocorticoid Receptor (MR) blockade is a highly effective strategy for the management of heart failure, but the use of MR antagonists (MRA) is limited by their side effects rendering them contraindicated in patients with renal failure. Finerenone is a new non-steroidal MRA that shows fewer hyperkaliaemic events than the traditional steroidal MRAs and could therefore represent an alternative to these molecules in patients with damaged kidney function...
August 2018: Journal of Molecular and Cellular Cardiology
Pavlos Kashioulis, Jaana Lundgren, Emman Shubbar, Lisa Nguy, Aso Saeed, Cecilia Wallentin Guron, Gregor Guron
BACKGROUND/AIMS: Cardiovascular disease is the major cause of death in patients with chronic kidney disease (CKD). Rats with adenine-induced chronic renal failure (ACRF) develop severe renal insufficiency and metabolic abnormalities that closely resemble those in patients with uremia. The aim of the present study was to determine left ventricular (LV) morphology and function in rats with ACRF. METHODS: Male Sprague-Dawley rats received either chow containing adenine or were pair-fed an identical diet without adenine (controls, C)...
2018: Kidney & Blood Pressure Research
David A Jaques, Hajo Müller, Chantal Martinez, Sophie De Seigneux, Pierre-Yves Martin, Belen Ponte, Patrick Saudan
BACKGROUND: Few studies have assessed the role of 24-h ambulatory blood pressure monitoring (ABPM) in adults with nondialysis chronic kidney disease (CKD). We examined the potential determinants of left ventricular hypertrophy (LVH) and mass index (LVMI) in this population. PARTICIPANTS AND METHODS: We carried out a cross-sectional study on 69 stage 3b-5 CKD adults who had ABPM and transthoracic echocardiography performed simultaneously. Hypertension (HT) was defined as 24 h blood pressure (BP) of at least 130/80 mmHg...
October 2018: Blood Pressure Monitoring
Ufuk Yildirim, Okan Gulel, Alay Eksi, Melda Dilek, Sabri Demircan, Mahmut Sahin
The aim of this study was to compare left ventricular (LV) functions by speckle tracking echocardiography (STE) in chronic kidney disease (CKD) patients in various stages and under different renal replacement treatments in order to evaluate possible differences between them. This prospective study included 150 patients with CKD. Renal transplantation patients with glomerular filtration rate greater than 60 ml/min/1.73 m2 , patients receiving hemodialysis three times a week, and patients in the predialysis stage with glomerular filtration rate less than 30 ml/dk/1...
November 2018: International Journal of Cardiovascular Imaging
Lyudmila Milovanova, Victor Fomin, Sergey Moiseev, Marina Taranova, Yury Milovanov, Lidia Lysenko Kozlovskaya, Vasiliy Kozlov, Elena Kozevnikova, Svetlana Milovanova, Marina Lebedeva, Vladimir Reshetnikov
BACKGROUND: A low protein diet (LPD) with essential amino acid ketoanalogue supplementation (KA) may contribute in improving of chronic kidney disease (CKD), while the exact mechanisms of KA's effect are not established yet. We have conducted a prospective, randomized, controlled comparative study of LPD + KA and LPD alone in relation to serum Klotho, FGF-23 levels in CKD patients. METHODS: 79 non-diabetic CKD 3b-4 stage patients, compliant with LPD diet (0...
December 2018: Clinical and Experimental Nephrology
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