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Marwan Odeh, Ayat Qasoum, Rene Tendler, Mohamad Kais, Rola Khamise Farah, Jacob Bornstein
OBJECTIVE:  Frozen section examination is a rapid method for identifying products of conception in endometrial curetting, yet its accuracy is inconclusive. The purposes of this study is to determine the accuracy of frozen section analysis of endometrial curetting in pregnancies of unknown location, and to verify the relation of β-human chorionic gonadotrophin (hCG) level and endometrial thickness to the assessed accuracy. METHODS:  We reviewed data from January 2009 to December 2014 of diagnostic curettages from women with suspected ectopic pregnancies sent for frozen section examination at a medical center...
December 12, 2018: Revista Brasileira de Ginecologia e Obstetrícia
Monika Bullinger, Jens Kuhn, Karolina Leopold, Wolfgang Janetzky, Rita Wietfeld
Consideration of quality of life has developed into an important concept of a patient-oriented medicine in the last 50 years. With it, it should be possible to capture the subjective experience of the patients and describe its different dimensions. Today, the quality of life as a patient-reported endpoint is also an integral part of the early benefit assessment under the German Drug Market Reorganization Act. In the treatment of schizophrenic patients, however, improvement in quality of life as an accepted target criterion has only been established with delay...
December 12, 2018: Fortschritte der Neurologie-Psychiatrie
Alpha Oumar Diallo, Asha Krishnaswamy, Stuart K Shapira, Matthew E Oster, Mary G George, Jenna C Adams, Elizabeth R Walker, Paul Weiss, Mohammed K Ali, Wendy Book
Background: The prevalence of moderate or complex (moderate-complex) congenital heart defects (CHDs) among adults is increasing due to improved survival, but many patients experience lapses in specialty care or their CHDs are undocumented in the medical system. There is, to date, no efficient approach to identify this population. Objective: To develop and assess the performance of a risk score to identify adults aged 20-60 years with undocumented specific moderate-complex CHDs from electronic health records (EHR)...
December 1, 2018: Journal of the American Medical Informatics Association: JAMIA
Huan Liu, Shu Zhang, Xi Jiang, Tuo Zhang, Heng Huang, Fangfei Ge, Lin Zhao, Xiao Li, Xintao Hu, Junwei Han, Lei Guo, Tianming Liu
The human cerebral cortex is highly folded into diverse gyri and sulci. Accumulating evidences suggest that gyri and sulci exhibit anatomical, morphological, and connectional differences. Inspired by these evidences, we performed a series of experiments to explore the frequency-specific differences between gyral and sulcal neural activities from resting-state and task-based functional magnetic resonance imaging (fMRI) data. Specifically, we designed a convolutional neural network (CNN) based classifier, which can differentiate gyral and sulcal fMRI signals with reasonable accuracies...
December 12, 2018: Cerebral Cortex
Yvonne Lamers, Amanda J MacFarlane, Deborah L O'Connor, Bénédicte Fontaine-Bisson
The Government of Canada and the Society of Obstetricians and Gynaecologists of Canada both recommend a daily multivitamin supplement containing 400 µg folic acid (FA) for the primary prevention of neural tube defects among low-risk women from before conception and throughout lactation. Prenatal supplements marketed and prescribed in Canada typically exceed the recommended dose, usually providing ≥1000 µg FA/d. This high daily dose, coupled with staple-food FA fortification, has resulted in the observation of very high blood folate concentrations among reproductive-aged women consuming FA-containing supplements...
December 1, 2018: American Journal of Clinical Nutrition
S S Malchau, A A Henningsen, J Forman, A Loft, A Nyboe Andersen, A Pinborg
STUDY QUESTION: Is the number of aspirated oocytes in the first ART cycle associated with the cumulative live birthrates (CLBR) in subsequent cycles? SUMMARY ANSWER: The number of aspirated oocytes in the first cycle was associated with CLBR in subsequent cycles. Previous treatment response predicts outcome in future cycles. WHAT IS KNOWN ALREADY: Previous reports have shown a positive association between the number of retrieved oocytes and live birthrate per fresh treatment cycle...
December 12, 2018: Human Reproduction
Jacinta H Martin, R John Aitken, Elizabeth G Bromfield, Brett Nixon
BACKGROUND: DNA integrity and stability are critical determinants of cell viability. This is especially true in the female germline, wherein DNA integrity underpins successful conception, embryonic development, pregnancy and the production of healthy offspring. However, DNA is not inert; rather, it is subject to assault from various environment factors resulting in chemical modification and/or strand breakage. If structural alterations result and are left unrepaired, they have the potential to cause mutations and propagate disease...
December 12, 2018: Human Reproduction Update
Yvette Audrey Assouni Mindjah, Félix Essiben, Pascal Foumane, Julius Sama Dohbit, Emile Telesphore Mboudou
OBJECTIVE: To identify the risk factors for ectopic pregnancy (EP) in a population of Cameroonian women. SAMPLE AND METHODS: We performed a matched case-control study; 88 women with diagnosed EP (cases), and 176 women with first trimester intrauterine pregnancy (IUP) (controls), who underwent questionnaires. Odds Ratio (OR) and 95% confidence intervals (CIs) were calculated and adjusted for potential confounding factors via multivariate logistic regression analysis...
2018: PloS One
Rita Chen, Nora M Bello, Mark W Becker, Laura Bix
BACKGROUND: Unintentional exposure to medications is a noted problem in pediatric populations despite the prevalent use of child-resistant (CR) packaging and educational campaigns informing consumers about appropriate storage. OBJECTIVE: Conduct a proof-of concept study that evaluates how package designs that engage the attention of children in meaningless ways affect opening time and number of openings. STUDY DESIGN: Non-CR vials with or without distracters were provided to 108 children (24-51 months) in pairs...
2018: PloS One
Mary Fran Tracy, Linda Chlan, Kay Savik, Debra J Skaar, Craig Weinert
BACKGROUND: Although potent sedative and opioid drugs are some of the most commonly used medications to manage pain, anxiety, and discomfort in critically ill patients, conducting clinical trials where sedative and opioid medications are outcome variables within a longitudinal research design can be a methodological challenge. OBJECTIVES: The purpose of this article is to provide in detail a conceptual discussion of the concept and analysis of sedative exposure: A novel research analysis method for aggregating sedative and opioid medication doses from disparate drug classes commonly administered to critically ill patients and used by our team in several clinical research studies...
January 2019: Nursing Research
Michelle L Litchman, Thomas Schlepko, Tom Rowley, Mary McFarland, Michelle Fiander
BACKGROUND AND PURPOSE: The Advanced Practice Registered Nurses (APRN) Consensus Model was produced by the APRN Joint Dialogue Group in 2008. The aim of the Consensus Model is to guide state boards on the implementation of APRN practice components, including licensure, accreditation, certification, and education and to clarify the legal scope of practice and APRN roles. The purpose of this scoping review and gap analysis was to appraise the evidence related to patient, nurse practitioner (NP) and organizational outcomes resulting from the Consensus Model...
December 2018: Journal of the American Association of Nurse Practitioners
Malte Bellmann, Thomas Maximilian Köhler, Thomas Schmalz
Safety-relevant gait situations (walking on stairs and slopes, walking backwards, walking with small steps, simulated perturbations of swing phase extension) were investigated in a motion analysis laboratory with six unilateral transfemoral amputees using two different microprocessor-controlled prosthetic knee joints (Rheo Knee XC, C-Leg). A randomized crossover design was chosen. The study results imply that the performance and safety potential of a microprocessor-controlled knee joint can be associated with the individual control algorithms and the technological concepts that are implemented to generate motion resistances for controlling flexion and extension movements...
December 12, 2018: Biomedizinische Technik. Biomedical Engineering
Poh Heng Chong, Catherine Walshe, Sean Hughes
BACKGROUND: For children with life-shortening illness, achieving a "good death" can be a tacit goal. There is little understanding of how different stakeholders perceive what a "good death" might be. OBJECTIVE: To review empirical literature to construct an understanding of a "good death" for children with life-shortening conditions. DESIGN: An integrative review approach was followed. This involved searching across Embase, Web of Science, Medline, CINAHL, and PsycINFO (no date limits set), as well as identifying eligible studies tracking reference lists...
December 11, 2018: Journal of Palliative Medicine
Mingzhong Wang, Longxuan Xu, Guowei Chen, Xiaopeng Zhao
Improving luminescent intensity is a significant technical requirement and scientific problem for the luminescent performance of fluorophor materials through the ages. The process control and luminescence performance still limit the developments of luminescent intensity even through it can be improved partly by covering or magnetron sputtering of precious metals on the surface of the fluorophore materials. On the basis of the improvement of luminescence center radiative transition rate by surface plasma resonance and Y2 O3 :Eu3+ microsheet phosphors, a fundamental model for topological luminophor Y2 O3 :Eu3+ +Ag was designed referencing the concepts of topological materials in order to enhance luminescent performance by composite-luminescence, which composed of Eu3+ centric electroluminescence and surface plasma-enhanced photoluminescence by Ag...
December 12, 2018: ACS Applied Materials & Interfaces
Hui Yang, Xian-Ying Duan, Jia-Jia Lai, Yan Zhao, Xin-Jun Wang, Mei-Lin Wei
Cocrystals and isomers, two well-known unique concepts in supramolecular chemistry, are rarely put together until now. For the first time, we report three unprecedented and interesting cocrystals of twin isomers of coordination polymers (CPs) in situ formed by typical Keggin anions and Cu(II)-4,4'-bis(hydroxymethyl)-2,2'-bipyridine (Cu(II)-H2 L) complex moieties. In cocrystals 1-3, the Cu(II)-H2 L complex moieties are quadrisupported on Keggin-type anions through W(Mo)-Ot-Cu-Ot-W(Mo) (Ot is the terminal O atom) links in the crystal to form two twin ionic/neutral CPs with a fixed chemical stoichiometry...
December 12, 2018: Inorganic Chemistry
Csilla Ágoston, Orsolya Király, Zsolt Demetrivics
INTRODUCTION: Our study is based on the concept that mental disorders - including psychotic symptoms - should be treated as dimensions/continuums rather than categories; an approach supported in the DSM-5 as well. Consequently, the measurement of certain symptoms of psychosis (e.g. hallucinations, persecutory ideation) may also be important in the normal population. We have performed the Hungarian adaptation of two questionnaires - the Persecutory Ideation Questionnaire and the Launay-Slade Hallucination Scale - in the current study and we also examined the relationship of the consumption of various caffeinated beverages, caffeine use disorder, the tendency to hallucinations and persecutory ideations...
2018: Psychiatria Hungarica: A Magyar Pszichiátriai Társaság Tudományos Folyóirata
Åsa B Gustafsson, Gerald W Dorn
The central functions fulfilled by mitochondria as both energy generators essential for tissue homeostasis and gateways to programmed apoptotic and necrotic cell death mandate tight control over the quality and quantity of these ubiquitous endosymbiotic organelles. Mitophagy, the targeted engulfment and destruction of mitochondria by the cellular autophagy apparatus, has conventionally been considered as the mechanism primarily responsible for mitochondrial quality control. However, our understanding of how, why, and under what specific conditions mitophagy is activated has grown tremendously over the past decade...
January 1, 2019: Physiological Reviews
Hiram Shaish, Simukayi Mutasa, Jasnit Makkar, Peter Chang, Lawrence Schwartz, Firas Ahmed
OBJECTIVE: The purpose of this study is to determine whether a convolutional neural network (CNN) can predict the maximum standardized uptake value (SUVmax ) of lymph nodes in patients with cancer using the unenhanced CT images from a PET/CT examination, thus providing a proof of concept for potentially using deep learning to diagnose nodal involvement. MATERIALS AND METHODS: Consecutive initial staging PET/CT scans obtained in 2017 for patients with pathologically proven malignancy were collected...
December 12, 2018: AJR. American Journal of Roentgenology
Rachel A Bergstrom
Science, technology, engineering, and math (STEM) continue to work to increase the diversity of the fields, yet there are still significant historical and societal hurdles to be overcome before we reach full representation throughout STEM. The concept of science identity has become a point of interest in this process; it has been suggested that development of one's identity as a scientist is critical to persistence in the field. Metaphors that are rooted in bodily experience can provide a starting point to understand abstract concepts, including science identity and how we as STEM educators respond to increasing diversity within our fields...
March 1, 2019: Advances in Physiology Education
Katharine Semsar, Sara Brownell, Brian A Couch, Alison J Crowe, Michelle K Smith, Mindi M Summers, Christian D Wright, Jennifer K Knight
We describe the development of a new, freely available, online, programmatic-level assessment tool, Measuring Achievement and Progress in Science in Physiology, or Phys-MAPS ( ). Aligned with the conceptual frameworks of Core Principles of Physiology, and Vision and Change Core Concepts, Phys-MAPS can be used to evaluate student learning of core physiology concepts at multiple time points in an undergraduate physiology program, providing a valuable longitudinal tool to gain insight into student thinking and aid in the data-driven reform of physiology curricula...
March 1, 2019: Advances in Physiology Education
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