Read by QxMD icon Read


Christiane Ganter-Argast, Martin Teufel, Isa Sammet, Sefik Tagay, Stephan Zipfel, Johannes Mander
Art therapy is a clinically accepted method of therapy, but there are still very few studies that deal with the efficacy, change factors or mode of action of art therapy. In particular, there is a dearth of research instruments and psychometrically verified research tools specially fitted for art therapy which measures the experience dimensions of the art therapy group from the patient's point of view. Hence, it provides evidence of its effectiveness, better understands the art therapy group processes and serves quality assurance...
October 16, 2018: Psychotherapie, Psychosomatik, Medizinische Psychologie
Lavinia A Carabet, Nada Lallous, Eric Leblanc, Fuqiang Ban, Helene Morin, Sam Lawn, Fariba Ghaidi, Joseph Lee, Ian G Mills, Martin E Gleave, Paul S Rennie, Artem Cherkasov
While Myc is an essential regulator of growth in normal cells, it is also frequently associated with cancer progression, therapy-resistance and lethal outcomes in most human cancers. In prostate cancer (PCa), Myc transcription factors are implicated in the pathogenesis and progression of the full spectrum of PCa, from adenocarcinoma to advanced castration-resistant and neuroendocrine phenotypes. Though a high-value therapeutic target, clinically approved anti-Myc drugs have yet to be discovered. To elicit its oncogenic effects, Myc must form a heterodimer with its partner Max, which together bind DNA and activate transcription of a spectrum of target genes that promote cell growth, proliferation, metabolism, and apoptosis while blocking differentiation...
September 11, 2018: European Journal of Medicinal Chemistry
Qian Li, Feng Wang, Yang Yu, Zhengce Huang, Mantao Li, Yuntao Guan
Sponge city construction is a new concept of urban stormwater management, which can effectively relieve urban flooding, reduce non-point source pollution, and promote the usage of rainwater resources, often including the application of Low Impact Development (LID) techniques. Although 30 cities in China have been chosen to implement sponge city construction, there is a lack of a quantitative evaluation method to evaluate the environmental, economic, and social benefits of LID practices. This paper develops a comprehensive evaluation system to quantify the benefits of different combinations of LID units using the Storm Water Management Model (SWMM) and the Analytical Hierarchy Process (AHP) method...
October 13, 2018: Journal of Environmental Management
Benjamin Saunders, Bernadette Bartlam, Majid Artus, Kika Konstantinou
Sciatica is a common form of low back pain (LBP) that has been identified as distinct both in terms of the persistence and severity of symptoms. Little research has explored individual experiences of sciatica, and none focuses on individuals with the most severe, long-lasting symptoms who may experience the most profound impact. This paper addresses this gap through proposing a theoretical framework for understanding such experiences, that of biographical suspension as a form of liminality of Self. Twenty semi-structured interviews were conducted with individuals with severe sciatic symptoms between January 2016‒March 2017, as part of the UK-based SCOPiC (SCiatica Outcomes in Primary Care) randomised controlled trial...
October 2, 2018: Social Science & Medicine
Paraskevi Mavrogiorgou, Björn Enzi, Saskia Steinmann, Christoph Mulert, Georg Juckel
OBJECTIVE: The so-called neuroanatomical hypothesis (with an increased activity of orbitofrontal cortex [OFC]) and the serotonergic hypothesis (with low activity in this system) have been discussed regarding the pathogenesis of obsessive-compulsive disorder (OCD) for decades. This study aimed to look for a relationship between the 2 pathogenetic concepts. METHODS: Nineteen OCD patients (8 female, 11 male, mean ± SD age = 33.37 ± 11.73 years, Yale-Brown Obsessive Compulsive Scale: 21...
October 9, 2018: Journal of Clinical Psychiatry
Christopher Parker, Valerie Lewington, Neal Shore, Clemens Kratochwil, Moshe Levy, Ola Lindén, Walter Noordzij, Jae Park, Fred Saad
Importance: Targeted alpha therapy attempts to deliver systemic radiation selectively to cancer cells while minimizing systemic toxic effects and may lead to additional treatment options for many cancer types. Observations: Theoretically, the high-energy emission of short-range alpha particles causes complex double-stranded DNA breaks, eliciting cell death. No known resistance mechanism to alpha particles has been reported or scientifically established. The short-range emission of alpha particle radiation confines its cytotoxic effect to cancerous lesions and the surrounding tumor microenvironment while limiting toxic effects to noncancerous tissues...
September 20, 2018: JAMA Oncology
Zehra Jamil, Syeda Sadia Fatima, Amna Afzal Saeed
OBJECTIVE: To explore the potentials of technology-assisted assessment for learning using Kahoot software in teaching session. METHODS: This cross-sectional study was conducted at Aga Khan University, Karachi, to investigate the usefulness of formative assessment based on the use of Kahoot, a quiz-based learning platform, in undergraduate setting.Six lectures were offered to undergraduate medical students with integration of assessment for learning (AfL) activities...
June 2018: JPMA. the Journal of the Pakistan Medical Association
Rehana Rehman, Mussarat Ashraf, Anila Jasmine, Karishma Lal, Faiza Alam
OBJECTIVE: To evaluate the role of tumour necrosis factor alpha and interleukin-6 in conception after assisted reproductive treatment. METHODS: The longitudinal cohort study was conducted from August 2014 to May 2015 and comprised patients undergoing intracytoplasmic sperm injection at the Islamabad Clinic Serving Infertile Couples, Islamabad, Pakistan. During the procedure, endometrial thickness was measured on the day of ovulation induction and serum tumour necrosis factor alpha along with interleukin-6 were measured on the embryo transfer day...
June 2018: JPMA. the Journal of the Pakistan Medical Association
Jose Serrano, Dana K Andersen, Christopher E Forsmark, Stephen J Pandol, Ziding Feng, Sudhir Srivastava, Jo Ann S Rinaudo
Research progress in diseases of the exocrine pancreas [chronic pancreatitis (CP), pancreatogenic diabetes mellitus, and pancreatic cancer] has been hampered by the disorders' heterogeneity, the limitations of previous small cross-sectional studies, the inability to safely obtain pancreatic tissue for study, and the lack of structured epidemiology tools, genetic testing, and biomarker development. Mechanism-based research of these diseases has suffered from the lack of systematically collected clinical measures in longitudinal cohort studies linked with biospecimens...
November 2018: Pancreas
Paul Brinkman, Anke-Hilse Maitland-van der Zee, Ariane H Wagener
PURPOSE OF REVIEW: The long-term management goals of the inflammatory airway diseases asthma and chronic obstructive pulmonary disease (COPD) are similar and focus on symptom control and reduction of exacerbation frequency and severity. Treatable traits have recently been postulated as a management concept which complements the traditional diagnostic labels 'asthma' and 'COPD', thereby focusing on therapy targeted to a patients' individual disease-associated characteristics. Exhaled volatile organic compounds (VOCs) may be utilized as noninvasive biomarker for disease activity or manifestation in asthma and COPD...
October 15, 2018: Current Opinion in Pulmonary Medicine
Ellinor Tengelin, Pia H Bülow, Ina Berndtsson, Elisabeth Dahlborg Lyckhage
The documents and literature that regulate nursing education are based on certain values and knowledge, and the underlying power in the curriculum raises the question of how health care professionals are molded during the course of their education. Norm criticism is a concept with its roots in critical pedagogy and gender and queer studies, emphasizing the origins as well as the consequences of marginalization, power, and knowledge of what is generally accepted as "normal" and "true." Norm criticism is used in this article to analyze the documents and literature underlying a nursing program in Sweden, which are shown to include a sometimes politically correct rhetoric, but one lacking a firm basis in social justice values...
October 13, 2018: ANS. Advances in Nursing Science
Xing Chen, Na-Na Guan, Ya-Zhou Sun, Jian-Qiang Li, Jia Qu
Small molecule is a kind of low molecular weight organic compound with variety of biological functions. Studies have indicated that small molecules can inhibit a specific function of a multifunctional protein or disrupt protein-protein interactions and may have beneficial or detrimental effect against diseases. MicroRNAs (miRNAs) play crucial roles in cellular biology, which makes it possible to develop miRNA as diagnostics and therapeutic targets. Several drug-like compound libraries were screened successfully against different miRNAs in cellular assays further demonstrating the possibility of targeting miRNAs with small molecules...
October 16, 2018: Briefings in Bioinformatics
Qi-Qi Yang, Rui-Tong Liu, Chao Huang, Yi-Fan Huang, Lin-Feng Gao, Bing Sun, Zhi-Peng Huang, Lei Zhang, Chen-Xia Hu, Ze-Qi Zhang, Chun-Lin Sun, Qiang Wang, Yu-Long Tang, Hao-Li Zhang
The rediscovery of black phosphorus (BP) has expanded the 2D family into Group 15 (Nitrogen Group) elements, among which bismuthene is the latest member with extraordinary opto-electronic, catalytic and biocompatible properties and potential as a 2D topological insulator. However, bulk Bi is not easily mechanically exfoliated as its counterpart of BP. Thus, to date, the reports on 2D Bi fabrication are rare, and investigations on its nonlinear optical properties are even less. Herein, we rationally designed a new strategy combining acid-interaction and liquid exfoliation to successfully transform metal bulk Bi into few-layer semiconductor, which resulted in unseen opto-electronic properties, such as tunable nonlinear responses all the way to the near-infrared (NIR) region...
October 16, 2018: Nanoscale
Sui Li, Dai Xi Xiu, Tie Mao Shi, Shi Wen Zhou, Shi Lei Fu, Chang Yu
Low impact development (LID) of industrial parks is an important component in the construction of China's sponge cities. We compared the methods of optimizing ecological spatial structure for rain and flood control in industrial parks, via analyzing the influence of landscape pattern on hydrological process. Firstly, according to the hydrological and geological conditions of the coastal area, the landscape pattern of the industrial park was optimized, with the water corridor system being structured and green patches being integrated...
October 2018: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
Mohamed Mahjoub, Sihem Ben Fredj, Nebiha Bouafia, Rym Bouriga, Naceur Ben Jalleb, Mansour Njah
BACKGROUND: promoting patient safety culture is a strategic priority and converges towards improving quality of health care. The healthcare professionals-patient relationship is an essential concept of patient safety culture. However, the increase of patient safety awareness is still delayed in Tunisia. OBJECTIVE: to assess and analyze the healthcare professional-patient relationship level among all healthcare professionals' categories in university hospital centre (UHC)FarhatHached, Sousse¬ Tunisia in order to further direct our strategies...
February 2018: La Tunisie Médicale
Foruhar Moayeri, David Dunt, Ya-Seng Arthur Hsueh, Colleen Doyle
PURPOSE: Depression and anxiety are commonly comorbid in Chronic Obstructive Pulmonary Disease (COPD) and associated with high health services utilization and deterioration of the quality of life. This study evaluated the cost-utility of telephone-based cognitive behavioural therapy (TB-CBT) (experimental arm) in comparison with a placebo-befriending (control arm) program in COPD participants with mild to severe depression and/or anxiety. METHODS: The Assessment of Quality of Life (AQoL-4D) scale was used to conduct the cost-utility analysis...
October 16, 2018: Expert Review of Pharmacoeconomics & Outcomes Research
Tyler P Killinger, Kristen Couper Schellhase
CONTEXT: National Collegiate Athletic Association (NCAA) institutions are required to certify insurance coverage of medical expenses for injuries student-athletes sustain while participating in NCAA events. Institutions assign this role to a variety of employees, including athletic trainers (ATs), athletic administrators, business managers, secretaries, and others. In 1994, Street et al observed that ATs were responsible for administering medical claim payments at 68.1% of institutions...
October 16, 2018: Journal of Athletic Training
Danielle Clucas, Lucy C Fox, Erica M Wood, Frank S Hong, John Gibson, Ashish Bajel, Jeff Szer, Piers Blombery, Zoe K McQuilten, Devendra Hiwase, Frank Firkin, Merrole F Cole-Sinclair
Acquired aplastic anaemia is a rare, serious, immunologically-mediated bone marrow failure syndrome, characterised by marrow hypoplasia of varying severity and significant pancytopenia. Careful attention and investigation, including molecular testing, is required to confirm the diagnosis and exclude other mimicking conditions, such as inherited bone marrow failure syndromes. In a proportion of patients, the disease evolves to myelodysplasia or acute myeloid leukaemia and in some there is an association with paroxysmal nocturnal haemoglobinuria...
October 15, 2018: Internal Medicine Journal
Zhifang Guo, Victoria Blair, Glen B Deacon, Peter Courtney Junk
Tris(pentafluorophenyl)bismuth has been examined as a potential replacement for diarylmercurials in redox transmetallation/protolysis (RTP) syntheses of reactive rare earth compounds from free rare earth metals, HgAr2, and a proligand HL. Thus, the lanthanoid pyrazolates, [Ln(Ph2pz)3(thf)3] (Ph2pz = 3,5-diphenylpyrazolate; Ln = La, 1, Ce, 2, Nd, 3, Tb, 4; thf = tetrahydrofuran), [Ln2(Ph2pz)4(OMe)2(dme)2]·2dme (Ln = Ho, 5, Er, 6, Tm, 7, Lu, 8; dme = 1,2-dimethoxyethane), [Ln(Ph2pz)3(dme)2] (Ln = Dy, 9, Sm, 10), [Ln(tBu2pz)3(thf)2] (tBu2pz = 3,5-di-tert-butylpyrazolate; Ln = La, 11, Ce, 12, Sm, 13, Gd, 14, Dy, 15, Ho, 16, Tm, 17, Yb, 18, Lu, 19), [Ln(ttfpz)3(thf)3] (ttfpz = 3-(2´-thienyl)-5-(trifluoromethyl)pyrazolate; Ln = La, 20, Sm, 21), and [Er(PhMepz)3(thf)2] 22 (PhMepz = 3-phenyl-5-methyl-pyrazolate) have been prepared in good yields by redox transmetallation/protolysis reactions employing lanthanoid metals, trispentafluorophenylbismuth [Bi(C6F5)3]·0...
October 15, 2018: Chemistry: a European Journal
Sumit Dadhwal, Jessica M Fairhall, Shailesh K Goswami, Sarah Hook, Allan Bernard Gamble
An alkene-azide 1,3-dipolar cycloaddition between trans-cyclooctene (TCO) and an azide-capped hydrogel that promotes rapid gel dissolution is reported. Using an ultrashort aryl azide-capped peptide hydrogel (PhePhe), we have demonstrated proof-of-concept where upon reaction with TCO, the hydrogel undergoes a gel-sol transition via 1,2,3-triazoline degradation and 1,6-self-immolation of the generated aniline. The potential application of this as a general trigger in sustained drug delivery is demonstrated through release of encapsulated cargo (doxorubicin)...
October 15, 2018: Chemistry, An Asian Journal
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"