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Laura Crane, Rachel Wilcock, Katie L Maras, Wing Chui, Carmen Marti-Sanchez, Lucy A Henry
Research suggests that autistic children can provide accurate and forensically useful eyewitness evidence. However, members of a jury also rely on non-verbal behaviours when judging the credibility of a witness, and this could determine the verdict of a case. We presented mock jurors with videos (from an experimental study) of one of two child witnesses on the autism spectrum being interviewed about a mock minor crime. Results demonstrated that providing jurors with generic information about autism and/or informing them of the child's diagnostic label differentially affected credibility ratings, but not for both children...
July 28, 2018: Journal of Autism and Developmental Disorders
Erin L Abner, Janna H Neltner, Gregory A Jicha, Ela Patel, Sonya L Anderson, Donna M Wilcock, Linda J Van Eldik, Peter T Nelson
Data from a large autopsy series were analyzed to address questions pertinent to primary age-related tauopathy (PART) and Alzheimer's disease (AD): what factors are associated with increased severity of neurofibrillary degeneration in brains that lack neuritic amyloid plaques?; is there an association between Apolipoprotein E (APOE) alleles and PART pathologic severity independent of amyloid-β (Aβ) deposits?; and, how do the stains used to detect plaques and tangles impact the experimental results? Neuropathologic data were evaluated from elderly research volunteers whose brain autopsies were performed at University of Kentucky Alzheimer's Disease Center (UK-ADC; N = 145 subjects)...
2018: Journal of Alzheimer's Disease: JAD
Paul Howard, Jan Remi, Constanze Remi, Sarah Charlesworth, Helen Whalley, Rebecca Bhatia, Morwenna Hitchens, Mary Mihalyo, Andrew Wilcock
No abstract text is available yet for this article.
July 20, 2018: Journal of Pain and Symptom Management
Natasha Lovell, Sabrina Bajwah, Matthew Maddocks, Andrew Wilcock, Irene J Higginson
BACKGROUND: Breathlessness remains a common and distressing symptom in people with advanced disease with few effective treatment options. Repurposing of existing medicines has been effective in other areas of palliative care, for example, antidepressants to treat pain, and offers an opportunity to deliver improved symptom control in a timely manner. Previous case series have shown reduced breathlessness following the use of sertraline (a selective serotonin reuptake inhibitor) in people with chronic obstructive pulmonary disease...
July 1, 2018: Palliative Medicine
Andrew Wilcock, Sim Koon, Cathann Manderson, Vicky Taylor, Matthew Maddocks
BACKGROUND: Breathlessness is common in patients with thoracic cancer but difficult to manage. The Incremental Shuttle Walking Test (ISWT) can help assess new treatments, but its repeatability has not been described in this group. AIM: To examine within and between day repeatability of the ISWT in this setting. METHODS: Patients with incurable thoracic cancer were recruited from outpatient clinics at a University Hospital. Two ISWTs were completed one hour apart on two consecutive days, with the first test for familiarization purposes only...
July 2018: Respiratory Medicine
Andrew Wilcock, Sarah Charlesworth, Claire Stark Toller, Rahul Girish, Mary Mihalyo, Paul Howard
Therapeutic Reviews aim to provide essential independent information for health professionals about drugs used in palliative and hospice care. Additional content is available on Country-specific books (Hospice and Palliative Care Formulary USA, and Palliative Care Formulary, British and Canadian editions) are also available and can be ordered from The series editors welcome feedback on the articles (
August 2018: Journal of Pain and Symptom Management
Sarah E Gollust, Andrew Wilcock, Erika Franklin Fowler, Colleen L Barry, Jeff Niederdeppe, Laura Baum, Pinar Karaca-Mandic
The effectiveness of health insurance advertising has gained renewed attention following the Trump administration's decision to reduce the marketing budget for the federal Marketplace. Yet there is limited evidence on the relationship between advertising and enrollment behavior. This study combined survey data from the 2014 National Health Interview Survey on adults ages 18-64 with data on volumes of televised advertisements aired in respondents' counties of residence during the 2013-14 open enrollment period...
June 2018: Health Affairs
Rachel Wilcock, Laura Crane, Zoe Hobson, Gilly Nash, Mimi Kirke-Smith, Lucy A Henry
Performance at identification lineup was assessed in eighty-five 6- to 11-year-old typically developing children. Children viewed a live staged event involving 2 male actors, and were asked to identify the perpetrators from 2 separate lineups (one perpetrator-present lineup and one perpetrator-absent lineup). Half the children took part in lineups adapted by a registered intermediary (an impartial, trained professional who facilitates understanding and communication between vulnerable witnesses and members of the justice system), and half took part in "best-practice" lineups, according to the current guidance for eyewitness identification in England and Wales...
May 2018: Applied Cognitive Psychology
Andrew Wilcock, Sarah Charlesworth
No abstract text is available yet for this article.
June 2018: BMJ Supportive & Palliative Care
Maria Claudia Bernardes Spexoto, Sergio Vicente Serrano, Vanessa Halliday, João Maroco, Andrew Wilcock, Juliana Alvares Duarte Bonini Campos
OBJECTIVE: To evaluate the psychometric properties, along with cross-cultural invariance analysis, of the Cancer Appetite and Symptom Questionnaire (CASQ). METHOD: Data from 555 United Kingdom (UK) cancer patients were used to evaluate the psychometric properties of the CASQ. Construct validity was assessed through factorial and convergent validity. We conducted a confirmatory factor analysis using as indices the chi-square ratio by degrees of freedom (χ2/df), the comparative fit index (CFI), the goodness of fit index (GFI), and the root mean square error of approximation (RMSEA)...
April 2018: Trends in Psychiatry and Psychotherapy
Susan Hayes, Nick Rheinberger, Meagan Powley, Tricia Rawnsley, Linda Brown, Malcolm Brown, Karen Butler, Ann Clarke, Stephen Crichton, Maggie Henderson, Helen McCosker, Ann Musgrave, Joyce Wilcock, Darren Williams, Karin Yeaman, T S Zaracostas, Adam C Taylor, Gordon Wallace
An artist-led exploration of portrait accuracy and likeness involved 12 Artists producing 12 portraits referencing a life-size 3D print of the same Sitter. The works were assessed during a public exhibition, and the resulting likeness assessments were compared to portrait accuracy as measured using geometric morphometrics (statistical shape analysis). Our results are that, independently of the assessors' prior familiarity with the Sitter's face, the likeness judgements tended to be higher for less morphologically accurate portraits...
June 2018: Perception
Jane Wilcock, David Taylor
No abstract text is available yet for this article.
May 2018: British Journal of General Practice: the Journal of the Royal College of General Practitioners
Marie T Fallon, Andrew Wilcock, Caroline A Kelly, James Paul, Liz-Anne Lewsley, John Norrie, Barry J A Laird
No abstract text is available yet for this article.
June 1, 2018: JAMA Oncology
Paul Wilcock, Rachel M Webster
No abstract text is available yet for this article.
May 2018: Nature Reviews. Drug Discovery
Sivakumar Subramaniam, Pauline Dand, Martin Ridout, Declan Cawley, Sophie Miller, Paola Valli, Rebecca Bright, Brendan O'Neill, Tricia Wilcocks, Georgina Parker, Dee Harris
OBJECTIVES: In palliative care settings, predicting prognosis is important for patients and clinicians. The Palliative Prognostic Index (PPI), a prognostic tool calculated using clinical indices alone has been validated within cancer population. This study was to further test the discriminatory ability of the PPI (ie, its ability to determine whether a subject will live more or less than a certain amount of time) in a larger sample but with a palliative care context and to compare predictions at two different points in time...
March 5, 2018: BMJ Supportive & Palliative Care
Joanne Bayly, Dominique Wakefield, Nilay Hepgul, Andrew Wilcock, Irene J Higginson, Matthew Maddocks
OBJECTIVES: International guidelines recommend that rehabilitation be offered to people with thoracic cancer to improve symptoms, function, and quality of life. When rehabilitation interventions require a change in behaviour, the use of theory and behaviour change techniques (BCTs) enhance participation. Our objective was to systematically identify BCTs and examine their use in relation to the Capability, Opportunity, Motivation-Behaviour model and known enablers and barriers to engagement in this population...
July 2018: Psycho-oncology
Andrew Wilcock, Sarah Charlesworth
No abstract text is available yet for this article.
March 2018: BMJ Supportive & Palliative Care
S A Lee, J Dunne, E Febery, P Wilcock, T Mottram, M R Bedford
1. The current study was conducted to investigate the effect of high phytase doses on growth performance and real-time gastric pH measurements in broiler chickens and pigs. 2. In the first experiment, 576 male Ross 308 broilers were fed in two phases (0-21 and 21-42 d) with 4 treatment groups, with diets meeting nutrient requirements containing 0, 500, 1500 or 2500 FTU/kg phytase. In the second, 64 Landrace weaners were fed on diets meeting nutrient requirements with or without phytase (0 or 2500 FTU/kg) in two phases (0-21 and 21-42 d)...
June 2018: British Poultry Science
V Leung, A Sastry, S Srivastava, D Wilcock, A Parrott, S Nayak
Endovascular mechanical thrombectomy (MT) is reserved for acute ischaemic stroke secondary to large vessel occlusion. The various MT techniques employed in the treatment of hyperacute strokes are constantly evolving with new devices and improvisation of existing technology (Wahlgren, et al 2016). In this review, we describe a variety of MT techniques gained from our experience of performing over 350 procedures in 7 years of providing a 24/7 service within the national framework of a hyperacute stroke centre...
May 2018: Clinical Radiology
Omar M Al-Janabi, Pradeep Panuganti, Erin L Abner, Ahmed A Bahrani, Ronan Murphy, Shoshana H Bardach, Allison Caban-Holt, Peter T Nelson, Brian T Gold, Charles D Smith, Donna M Wilcock, Gregory A Jicha
BACKGROUND AND PURPOSE: Interpreting the clinical significance of moderate-to-severe global cerebral atrophy (GCA) is a conundrum for many clinicians, who visually interpret brain imaging studies in routine clinical practice. GCA may be attributed to normal aging, Alzheimer's disease (AD), or cerebrovascular disease (CVD). Understanding the relationships of GCA with aging, AD, and CVD is important for accurate diagnosis and treatment decisions for cognitive complaints. METHODS: To elucidate the relative associations of age, moderate-to-severe white matter hyperintensities (WMHs), and moderate-to-severe medial temporal lobe atrophy (MTA), with moderate-to-severe GCA, we visually rated clinical brain imaging studies of 325 participants from a community based sample...
May 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
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