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idiopathic enteropathy

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https://www.readbyqxmd.com/read/30313113/successful-azathioprine-treatment-in-an-adolescent-with-chronic-enteropathy-associated-with-slco2a1-gene-a-case-report
#1
Keisuke Eda, Tatsuki Mizuochi, Yugo Takaki, Kosuke Ushijima, Junji Umeno, Yushiro Yamashita
INTRODUCTION: Chronic nonspecific multiple ulcers of the small intestine (CNSU), an entity with female preponderance and manifestations including anemia and hypoproteinemia reflecting persistent gastrointestinal bleeding and intestinal protein loss, has been considered idiopathic. Umeno et al recently reported that CNSU is caused by loss-of-function mutations in the solute carrier organic anion transporter family member 2A1 gene (SLCO2A1) encoding a prostaglandin transporter, renaming the disorder "chronic enteropathy associated with SLCO2A1 gene mutation" (CEAS)...
October 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30032386/gluten-neuropathy-prevalence-of-neuropathic-pain-and-the-role-of-gluten-free-diet
#2
Panagiotis Zis, Ptolemaios Georgios Sarrigiannis, Dasappaiah Ganesh Rao, Marios Hadjivassiliou
BACKGROUND AND AIM: Peripheral neuropathy is a common extraintestinal manifestation of gluten sensitivity (gluten neuropathy). We aimed to establish the prevalence of neuropathic pain in patients with otherwise idiopathic PN and gluten sensitivity (positive antigliadin, endomysial, and/or transglutaminase antibodies, with or without enteropathy) and to describe any contributory factors. METHODS: All consecutive patients with gluten neuropathy (GN) attending a specialist gluten/neurology clinic were invited to participate...
July 21, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29663515/determining-optimal-therapy-of-dogs-with-chronic-enteropathy-by-measurement-of-serum-citrulline
#3
Magda Gerou-Ferriani, Rhiannon Allen, Peter-John M Noble, Alexander J German, Marco Caldin, Daniel J Batchelor
BACKGROUND: Serum concentration of citrulline is a useful biomarker in human intestinal disease and indicates globally reduced enterocyte mass and absorptive function in various disease states. OBJECTIVES: To determine whether serum citrulline concentration is a biomarker in chronic enteropathy (CE) in dogs, to provide useful information regarding optimal treatment or to predict outcome. ANIMALS: Seventy-four dogs with CE and 83 breed- and age-matched hospital controls with no clinical signs of intestinal disease...
May 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29525901/perianal-minimally-invasive-surgery-pamis-for-rectal-stump-resection-after-previous-colectomy
#4
Andreas Lorenz, Pamela Kogler, Marcus Huth, Reinhold Kafka-Ritsch, Dietmar Öfner, Alexander Perathoner
PURPOSE: Resection of a long rectal stump after previous colectomy or Hartmann procedure often requires a combined transperitoneal and transperineal approach because of limited access through a perineal incision alone. Risks associated with this procedure include iatrogenic injury to bowels, nerves, ureters, vessels and sexual organs. This study reports on the feasibility and safety of perianal minimally invasive surgery (PAMIS) for the resection of long rectal stumps that would otherwise require a combined transperitoneal and perianal approach...
June 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29391315/a-rare-cause-of-multiple-small-bowel-ulcers-and-strictures-in-a-10-year-old-child
#5
Teera Kijmassuwan, Pornthep Tanpowpong, Sani Molagool, Suporn Treepongkaruna
Enteritis and small bowel ulcers can be caused by inflammatory bowel disease, drug-induced enteritis, cytomegalovirus, tuberculosis, or intestinal lymphoma. Cryptogenic multifocal ulcerous stenosing enteritis (CMUSE) is an uncommon idiopathic cause of ulceration and stricture of the small bowel. CMUSE can occur in adults, but only few pediatric cases have been reported. Inflammatory bowel disease and other causes should be carefully sought first before the diagnosis of CMUSE can be made. Previous reports demonstrated that surgical intervention may be necessary for both diagnostic and therapeutic purposes...
January 2018: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/28958380/disseminated-mycobacterium-avium-intracellulare-leading-to-protein-losing-enteropathy-in-an-elderly-man-with-idiopathic-cd4-lymphocytopenia
#6
Carlos J Perez-Lopez, Erving Arroyo, Maristely Rodriguez, Damarys Ortiz, Sylvette Nazario
No abstract text is available yet for this article.
October 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28886934/transglutaminase-6-antibodies-in-gluten-neuropathy
#7
Panagiotis Zis, Dasappaiah Ganesh Rao, Ptolemaios Georgios Sarrigiannis, Pascale Aeschlimann, Daniel P Aeschlimann, David Sanders, Richard A Grünewald, Marios Hadjivassiliou
BACKGROUND: TG6 antibodies have been shown to be a marker of gluten ataxia but their presence in the context of other neurological manifestations of gluten sensitivity has not been explored. We investigated the presence of TG6 antibodies in gluten neuropathy (GN), defined as as an otherwise idiopathic peripheral neuropathy associated with serological markers of gluten sensitivity (one or more of antigliadin IgG and/or IgA, endomysial and transglutaminase-2 antibodies). METHODS: This was a cross-sectional study conducted at the Sheffield Institute of Gluten Related Diseases, Royal Hallamshire Hospital, Sheffield, UK...
November 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28865226/evaluation-of-clinicopathological-features-in-cats-with-chronic-gastrointestinal-signs
#8
P Gianella, M Pietra, P E Crisi, P Famigli Bergamini, F Fracassi, M Morini, A Boari
Food-responsive enteropathy (FRE), idiopathic inflammatory bowel disease (IBD), and alimentary tract lymphoma (AL) are often the remaining differentials for cats presenting with chronic gastrointestinal (GI) signs. Differential diagnosis is further complicated by overlapping clinicopathological features and histopathological changes, however. In this study we describe the clinical presentation of cats with chronic GI signs secondary to FRE, IBD, and AL, and evaluate possible associations between clinical, clinicopathological, ultrasonographic findings and diagnosis...
March 1, 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/28703447/chronic-diarrhea-in-dogs-retrospective-study-in-136-cases
#9
M Volkmann, J M Steiner, G T Fosgate, J Zentek, S Hartmann, B Kohn
BACKGROUND: Chronic diarrhea (CD) is common in dogs, and information on frequency and distribution of primary and secondary causes is lacking. OBJECTIVES: To evaluate underlying causes and predictors of outcome in dogs with CD. ANIMALS: One hundred and thirty-six client-owned dogs with CD (≥3 weeks duration). METHODS: Retrospective review of medical records (Small Animal Clinic, Freie Universität Berlin, Germany, 09/2009-07/2011)...
July 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28510689/chronic-enteropathy-associated-with-slco2a1-gene-ceas-characterisation-of-an-enteric-disorder-to-be-considered-in-the-differential-diagnosis-of-crohn-s-disease
#10
Naoki Hosoe, Naoki Ohmiya, Fumihito Hirai, Junji Umeno, Motohiro Esaki, Hirokazu Yamagami, Kei Onodera, Shigeki Bamba, Hiroyuki Imaeda, Shunichi Yanai, Tadakazu Hisamatsu, Haruhiko Ogata, Takayuki Matsumoto
Small intestinal ulcers include mucosal damage caused by drugs, particularly nonsteroidal anti-inflammatory drugs [NSAIDs], infectious diseases, and idiopathic inflammatory bowel disease. Previously, a group of Japanese investigators reported an unusual and uncommon type of enteritis and referred to the condition as chronic nonspecific multiple ulcers of the small intestine [CNSU]. CNSU is characterised by chronic blood and protein loss through persistent small intestinal ulcers. Recently, four candidate mutations in the solute carrier organic anion transporter family, member 2A1 [SLCO2A1] gene, encoding a prostaglandin transporter, were identified by whole-exome sequencing in patients with CNSU...
October 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/27852543/screening-of-patients-with-juvenile-idiopathic-arthritis-and-those-with-rheumatoid-arthritis-for-celiac-disease-in-southwestern-iran
#11
Mozhgan Moghtaderi, Shirin Farjadian, Elham Aflaki, Naser Honar, Soheila Alyasin, Maryam Babaei
BACKGROUND/AIMS: Celiac disease (CD) is a common enteropathy triggered by the ingestion of gluten in genetically susceptible individuals. It is frequently found in conjunction with other autoimmune diseases. The purpose of this study was to investigate the prevalence of CD in patients with juvenile idiopathic arthritis (JIA) and those with rheumatoid arthritis (RA) in southwestern Iran. MATERIALS AND METHODS: A total of 53 children with JIA and 55 adults with RA were enrolled...
November 2016: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/27224999/protein-losing-enteropathy-in-camptodactyly-arthropathy-coxa-vara-pericarditis-cacp-syndrome
#12
Bram Peters, Janneke H M Schuurs-Hoeijmakers, Joris Fuijkschot, Annette Reimer, Michiel van der Flier, Dorien Lugtenberg, Esther P A H Hoppenreijs
BACKGROUND: Camptodactyly-arthropathy-coxa vara-pericarditis (CACP, OMIM: #208250) syndrome is a rare autosomal recessive disease that can be difficult to recognise not only because of its wide clinical variability but also because of its clinical resemblance to juvenile idiopathic arthritis (JIA). PRG4 is the only gene so far known to be associated with CACP syndrome. Children with CACP syndrome lack the glycoprotein lubricin due to recessive mutations in PRG4. Lubricin serves as a lubricant in joints, tendons and visceral cavities (pleural cavity, pericardium) and inhibits synovial proliferation...
May 25, 2016: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/27159733/retrospective-evaluation-of-the-administration-of-25-human-albumin-to-dogs-with-protein-losing-enteropathy-21-cases-2003-2013
#13
Kimberly A Loyd, Christine G Cocayne, Julie M Cridland, Wayne R Hause
OBJECTIVE: To describe the administration of 25% human serum albumin (HSA) to dogs diagnosed with idiopathic inflammatory bowel disease (IBD) and protein-losing enteropathy (PLE). The secondary objectives were to report any acute and delayed adverse events and the effect of corticosteroids on the development of these reactions. DESIGN: Retrospective study (2003-2013). SETTING: Private referral hospital. ANIMALS: Twenty-one client owned dogs diagnosed with PLE and idiopathic IBD that received ≥ 1 transfusion of 25% HSA...
July 2016: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/27017054/fecal-s100a12-concentration-predicts-a-lack-of-response-to-treatment-in-dogs-affected-with-chronic-enteropathy
#14
Romy M Heilmann, Maria Volkmann, Cristiane C Otoni, Niels Grützner, Barbara Kohn, Albert E Jergens, Jörg M Steiner
S100A12 is a potential biomarker of gastrointestinal inflammation in dogs and fecal S100A12 concentrations are correlated with disease severity and outcome. The aim of the present study was to investigate whether there was any association between pre-treatment fecal S100A12 concentrations in dogs affected with chronic enteropathy (CE) and the response to treatment. Dogs affected with CE were recruited into the study and were classified as antibiotic-responsive diarrhea (ARD; n = 9), food-responsive diarrhea (FRD; n = 30) or idiopathic inflammatory bowel disease (IBD; n = 25)...
September 2016: Veterinary Journal
https://www.readbyqxmd.com/read/26839099/diarrheal-illness-in-the-pediatric-population-a-review-of-neonatal-enteropathies-and-childhood-idiopathic-inflammatory-bowel-disease
#15
Eric U Yee, Jeffrey D Goldsmith
In the clinical context of pediatric diarrheal illness, the interpretation of endoscopic mucosal biopsies varies significantly from that in adults. This review outlines these differences by first describing a host of diarrheal illnesses that are nearly exclusive to the pediatric age group. The final portion of this article describes salient pathologic differences between adult and pediatric idiopathic inflammatory bowel disease. The goal of this review is to provide a brief description of each disease process and focus on practical aspects of diagnosis that are applicable for pathologists working in general practice settings...
September 2013: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/26552467/factors-related-to-outcomes-in-lupus-related-protein-losing-enteropathy
#16
Doo-Ho Lim, Yong-Gil Kim, Seung-Hyeon Bae, Soomin Ahn, Seokchan Hong, Chang-Keun Lee, Bin Yoo
BACKGROUND/AIMS: Protein-losing enteropathy (PLE), characterized by severe hypoalbuminemia and peripheral edema, is a rare manifestation of systemic lupus erythematosus. This present study aimed to identify the distinctive features of lupus-related PLE and evaluate the factors related to the treatment response. METHODS: From March 1998 to March 2014, the clinical data of 14 patients with lupus PLE and seven patients with idiopathic PLE from a tertiary center were reviewed...
November 2015: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/26495097/association-of-celiac-disease-with-idiopathic-pulmonary-hemosiderosis-lane-hamilton-syndrome
#17
Hikmet Tekin Nacaroglu, Ozlem Sarac Sandal, Ozlem Bag, Semiha Bahceci Erdem, Ozlem Bekem Soylu, Gulden Diniz, Aysel Ozturk, Demet Can
INTRODUCTION: Idiopathic Pulmonary Hemosiderosis (IPH) is a rare cause of alveolar hemorrhage, which is seen primarily in childhood. Celiac disease is defined as a chronic, immune-mediated enteropathy of the small intestine, caused by exposure to dietary gluten in genetically pre-disposed individuals. Association of IPH and celiac disease is known as Lane Hamilton syndrome. There are limited number of case reports of this syndrome in literature. CASE PRESENTATION: Although there were no growth and developmental delay and gastrointestinal symptoms like chronic diarrhea, chronic constipation, vomiting, abdominal bloating and pain in the two patients with IPH, they were diagnosed with Lane Hamilton Syndrome...
October 2015: Iranian Journal of Pediatrics
https://www.readbyqxmd.com/read/25925933/gluten-related-disorders-gluten-ataxia
#18
REVIEW
Marios Hadjivassiliou, David D Sanders, Daniel P Aeschlimann
The term gluten-related disorders (GRD) refers to a spectrum of diverse clinical manifestations triggered by the ingestion of gluten in genetically susceptible individuals. They include both intestinal and extraintestinal manifestations. Gluten ataxia (GA) is one of the commonest neurological manifestations of GRD. It was originally defined as otherwise idiopathic sporadic ataxia in the presence of circulating antigliadin antibodies of IgA and/or IgG type. Newer more specific serological markers have been identified but are not as yet readily available...
2015: Digestive Diseases
https://www.readbyqxmd.com/read/25755567/idiopathic-non-cirrhotic-intrahepatic-portal-hypertension-nciph-newer-insights-into-pathogenesis-and-emerging-newer-treatment-options
#19
REVIEW
Ashish Goel, Joshua E Elias, Chundamannil E Eapen, Banumathi Ramakrishna, Elwyn Elias
Chronic microangiopathy of portal venules results in idiopathic non-cirrhotic intrahepatic portal hypertension (NCIPH). Recent data suggest a role for vasoactive factors of portal venous origin in the pathogenesis of this 'pure' vasculopathy of the liver. Enteropathies (often silent), are an important 'driver' of this disease. NCIPH is under-recognized and often mis-labeled as cryptogenic cirrhosis. Liver biopsy is needed to prove the diagnosis of NCIPH. In these patients, with advancing disease and increased porto-systemic shunting, the portal venous vasoactive factors bypass the liver filter and contribute to the development of pulmonary vascular endothelial disorders-porto-pulmonary hypertension and hepato-pulmonary syndrome as well as mesangiocapillary glomerulonephritis...
September 2014: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/25728812/lack-of-correlation-between-mucosal-immunoglobulin-a-positive-plasma-cell-numbers-and-tlr5-genotypes-in-german-shepherd-dogs-with-idiopathic-chronic-enteropathy
#20
A Lee, A Kathrani, S L Priestnall, K Smith, D Werling, K Allenspach
It has been suggested previously that a deficiency in mucosal immunoglobulin (Ig) A production could be involved in the pathogenesis of chronic enteropathy in German shepherd dogs (GSDs). Recent research has shown that single nucleotide polymorphisms in the gene encoding Toll-like receptor (TLR)-5 are associated with an increased risk of development of chronic idiopathic enteropathy in this breed. IgA is essential for mucosal immunity and studies in mice have linked the interaction of TLR5 with its ligand flagellin to class switching of B cells into IgA-producing plasma cells...
February 2015: Journal of Comparative Pathology
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