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Diabetics Retinopathy

T Kakhniashvili, N Tabagari-Bregvadze, L Nikoleishvili, L Khuchua, R Kurashvili
Our aim was to evaluate the serum vascular endothelial growth factor (VEGF) level in type 2 diabetes patients with comorbid obstructive sleep apnea (OSA) and to compare it in connection with diabetic retinopathy and chronic kidney disease severity. In the prospective cohort study following data were collected: medical anamnesis; demographic and anthropometric data; laboratory (serum VEGF, complete blood count, biochemistry, immunology, complete urine test, including microalbuminuria) and instrumental investigation data (fundoscophy, laboratory polysomnography)...
October 2018: Georgian Medical News
Rana Shafabakhsh, Esmat Aghadavod, Majid Ghayour-Mobarhan, Gordon Ferns, Zatollah Asemi
Retinopathy, characterized by an alteration of the retinal microvasculature, is a common complication of diabetes mellitus. These changes can cause increased permeability and alter endothelial cell proliferation, edema, and abnormal neovascularization and eventually result in blindness. The pathogenesis of diabetic retinopathy (DR) is complicated, involving many factors/mediators such as genetic susceptibility, microRNAs, and cytokines. One of the factors involved in DR pathogenesis is epigenetic changes that can have a key role in the regulation of gene expression; these include microRNAs, histone modifications, and methylation of DNA...
December 4, 2018: Journal of Cellular Physiology
Li-Qiong Zhang, Hao Cui, Yong-Bin Yu, Huan-Qi Shi, Yuan Zhou, Mei-Jiao Liu
Retinal neovascularization occurs in various ocular disorders including proliferative diabetic retinopathy and secondary neovascular glaucoma, resulting in blindness. This paper aims to investigate the effect of microRNA-141-3p (miR-141-3p) on retinal neovascularization and retinal ganglion cells (RGCs) in glaucoma mice through the Docking protein 5 (DOK5)-mediated mitogen-activated protein kinase (MAPK) signaling pathway. Chip retrieval and difference analysis were used for the potential mechanism of miR-141-3p on glaucoma...
December 4, 2018: Journal of Cellular Physiology
Shipeng Li, Jianling Sun, Wenchao Hu, Yan Liu, Dan Lin, Haiping Duan, Fengting Liu
OBJECTIVE: Adropin, a newly identified regulatory protein encoded by Enho gene, is correlated with insulin sensitivity and diabetes. The aim of this study is to determine whether serum and vitreous adropin concentrations are correlated with the presence of diabetic retinopathy (DR). METHODS: A population of 165 patients with type 2 diabetes mellitus (T2DM) [52 without DR, 69 with non-proliferative diabetic retinopathy (NPDR), and 44 patients with proliferative diabetic retinopathy (PDR)] was enrolled in this study...
December 4, 2018: Annals of Clinical Biochemistry
Effat Alizadeh, Parviz Mammadzada, Helder André
Ocular angiogenic diseases, such as proliferative diabetic retinopathy and neovascular age-related macular degeneration, are associated with severe loss of vision. These pathologies originate from different vascular beds, retinal and choroidal microvasculatures, respectively. The activation of endothelial cells (EC) plays pivotal roles in angiogenesis, often triggered by oxygen deficiency. Hypoxia-inducible factors in ECs mediate the transcription of multiple angiogenic genes, including the canonical vascular endothelial growth factors...
December 3, 2018: International Journal of Molecular Sciences
Zhongxiao Wang, Chi-Hsiu Liu, Shuo Huang, Jing Chen
The Wnt signaling pathway plays a pivotal role in vascular morphogenesis in various organs including the eye. Wnt ligands and receptors are key regulators of ocular angiogenesis both during the eye development and in vascular eye diseases. Wnt signaling participates in regulating multiple vascular beds in the eye including regression of the hyaloid vessels, and development of structured layers of vasculature in the retina. Loss-of-function mutations in Wnt signaling components cause rare genetic eye diseases in humans such as Norrie disease (ND), and familial exudative vitreoretinopathy (FEVR) with defective ocular vasculature...
December 1, 2018: Progress in Retinal and Eye Research
Ozkan Sever
No abstract text is available yet for this article.
December 3, 2018: Acta Ophthalmologica
Sandra Aurell, Kersti Sjövall, Anna Paul, Åsa Morén, Elisabet Granstam
PURPOSE: To evaluate treatment outcome at 12 months in eyes with neovascular age-related macular degeneration (nAMD) treated with antivascular endothelial growth factor (anti-VEGF) injections according to either pro re nata (PRN)- or treat-and-extend (TE)-regimen in one clinical setting in Sweden. METHODS: Data were obtained retrospectively from the Swedish Macula Register, optical coherence tomography-database and electronic patient charts. The study included 443 eyes; 223 PRN- and 220 TE-treated eyes...
December 3, 2018: Acta Ophthalmologica
Peter Kuzmak, Charles Demosthenes, April Maa
The US Department of Veterans Affairs has been acquiring store and forward digital diabetic retinopathy surveillance retinal fundus images for remote reading since 2007. There are 900+ retinal cameras at 756 acquisition sites. These images are manually read remotely at 134 sites. A total of 2.1 million studies have been performed in the teleretinal imaging program. The human workload for reading images is rapidly growing. It would be ideal to develop an automated computer algorithm that detects multiple eye diseases as this would help standardize interpretations and improve efficiency of the image readers...
December 3, 2018: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
Irving Enrique Carral-Santander, Abril Santos-Palacios, Blanca Elizabeth Martínez-Baez, Linda Cernichiaro-Espinosa, Juan Manuel Elizondo-Camacho, Carlos Andrés Valdés-Lara, Virgilio Morales-Cantón, Raul Velez-Montoya
Purpose: To report a case of occlusive retinal vasculopathy, secondary to hyperhomocysteinemia. Observations: A 43-year-old male was examined at the retina outpatient clinic due to complaints of bilateral decrease in visual acuity. The patient underwent a comprehensive ophthalmological examination, wide-field fundus photographs and fluorescein angiography, as well as spectral domain optical coherence tomography with enhanced-deep imaging. The patient had a significant medical history of chronic kidney disease and progressive bilateral vision loss over the last two years, which worsened in the left eye during the past 3 months...
March 2019: American Journal of Ophthalmology Case Reports
Miao Liu, Jianhua Wang, Yao He
Aims: This study aimed at assessing the impact of baseline bilirubin (TBiL) on the incidence of diabetic retinopathy (DR) based on a five-year cohort study which consisted of 5323 Chinese male diabetic patients. Methods: A cohort study based on 5323 male diabetic patients was conducted in Beijing, from 2009 to 2013. Both baseline TBiL and follow-up changes were measured. Cox proportional risk model was used to calculate the hazard ratio (HR) of TBiL for DR risk...
2018: Journal of Diabetes Research
Ian A Thompson, Alia K Durrani, Shriji Patel
PURPOSE: The purpose of this study is to measure optical coherence tomography angiography (OCTA)-defined retinal vascular and choriocapillaris parameters in diabetic patients without clinically evident diabetic retinopathy. METHODS: Retrospective case series of eyes in patients with a documented history of either type 1 or type 2 diabetes mellitus without any clinical signs of diabetic retinopathy seen at the Vanderbilt Eye Institute. All eyes underwent dilated funduscopic examination along with OCTA...
December 3, 2018: Eye
Mehrdad Afarid, Adel Attarzadeh, Mohsen Farvardin, Hossein Ashraf
This study was performed to determine the association amongst serum leptin level and anthropometric measures with the severity of Diabetic Retinopathy (DR) in subjects with type 2 Diabetes Mellitus (DM). This case-controlled study was conducted within a one-year period, during year 2016, at outpatient retina ophthalmology clinics of Shiraz, southern Iran. Eighty-three patients with type 2 DM, referring for ophthalmoscopy evaluation, were included. Anthropometric measures, serum leptin level, and baseline laboratory assessment was performed for all subjects...
2018: Medical Hypothesis, Discovery and Innovation in Ophthalmology
Jose Leal, Ramon Luengo-Fernandez, Irene M Stratton, Angela Dale, Katerina Ivanova, Peter H Scanlon
BACKGROUND: Annually 2.7 million individuals are offered screening for diabetic retinopathy (DR) in England. Spectral-Domain Optical Coherence Tomography (SD-OCT) has the potential to relieve pressure on NHS services by correctly identifying patients who are screen positive for maculopathy on two-dimensional photography without evidence of clinically significant macular oedema (CSMO), limiting the number of referrals to hospitals. We aim to assess whether the addition of SDOCT imaging in digital surveillance clinics is a cost-effective intervention relative to hospital eye service (HES) follow-up...
November 30, 2018: Eye
Yuhua Chen, Jiao Meng, Hua Li, Hong Wei, Fangfang Bi, Shi Liu, Kai Tang, Haiyu Guo, Wei Liu
Diabetic retinopathy (DR), an obstacle of the visual microvascular system, is a serious complication of diabetic patients. Paraoxonase 1 (PON1) has been extensively evaluated as a genetic candidate for diabetic microvascular complications, and PON1 is associated with DR. In this study, the biological functions of PON1 and its related proteins were determined via gene ontology (GO) enrichment analysis; we demonstrated that treatment with resveratrol alleviated retinal inflammatory activities to evaluate its protective effects on streptozotocin (STZ)-induced diabetic rats and high-glucose (HG) stimulated rat retinal endothelial cells (RRECs)...
November 29, 2018: Experimental Eye Research
Warda Ali, Kanwal Zareen Abbasi, Ali Raza
OBJECTIVE: To compare panretinal photocoagulation (PRP) plus intravitreal bevacizumab (IVB) against PRP alone in the treatment of proliferative diabetic retinopathy (PDR) in terms of mean change in best corrected visual acuity (BCVA), neovessels on disc (NVD) and neovessels elsewhere (NVE). STUDY DESIGN: Experimental study. PLACE AND DURATION OF STUDY: Department of Ophthalmology, Benazir Bhutto Hospital, Rawalpindi, from December 2014 to July 2015...
December 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
S V Sdobnikova, V S Kulybysheva, A L Sidamonidze
Diabetes mellitus is one of the most common chronic diseases in the world. Among its late complications that can lead to disability is diabetic neuropathy (DN). Patients diagnosed with DN often also have diabetic retinopathy (DR). According to available data, DR prevalence ranges from 30 to 60%. For a long time, DR has been considered a microvascular disease. However, more data has been emerging recently that indicates the presence of other components in the pathophysiology of DR. Neurodegenerative changes in the retina can be detected in patients with diabetes mellitus before clinical signs of diabetic retinopathy appear...
2018: Vestnik Oftalmologii
L Samii, M Kallas-Koeman, L E Donovan, A Lodha, S Crawford, S Butalia
AIMS: To assess the association between vascular complications of diabetes and the risk of congenital malformations in pregnant women with Type 1 diabetes. METHODS: We conducted an observational retrospective cohort study in women with Type 1 diabetes who received care consecutively from three tertiary care diabetes-in-pregnancy clinics in Calgary, Alberta, Canada. Multivariable logistic regression was used to assess the association between vascular complications (retinopathy, nephropathy and pre-existing hypertension) and congenital malformations in offspring of women with Type 1 diabetes...
November 30, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
Danial Mohabati, Elon Hc van Dijk, Thomas J van Rijssen, Eiko K de Jong, Myrte B Breukink, Jose P Martinez-Ciriano, Greet Dijkman, Carel B Hoyng, Sascha Fauser, Suzanne Yzer, Camiel Jf Boon
Purpose: To describe a spectrum of severe chronic central serous chorioretinopathy (cCSC) cases and their response to photodynamic therapy (PDT). Patients and methods: A total of 66 patients (81 eyes) with active severe cCSC were studied, and their response to PDT was compared with a control group consisting of 35 active cCSCs (37 eyes) that did not display characteristics of severity. Best-corrected visual acuity (BCVA) and complete resolution of subretinal fluid (SRF) were considered as main outcome measures...
2018: Clinical Ophthalmology
Richard F Spaide, Luis Arias Barquet
PURPOSE: To investigate eyes with solitary large aneurysms arising from retinal capillaries. METHODS: Consecutive patients with aneurysms greater than 200 µm in diameter were evaluated with a comprehensive ophthalmologic examination including optical coherence tomography, optical coherence tomography angiography, and fluorescein angiography. The aneurysms were solitary in the sense, and there was only one aneurysm larger than the threshold diameter and a few or no other aneurysms...
November 21, 2018: Retina
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