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Diabetics Retinopathy

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https://www.readbyqxmd.com/read/30339883/oxidative-stress-mediated-by-lipid-metabolism-contributes-to-high-glucose-induced-senescence-in-retinal-pigment-epithelium
#1
Qingqiu Chen, Li Tang, Guang Xin, Shiyi Li, Limei Ma, Yao Xu, Manjiao Zhuang, Qiuyang Xiong, Zeliang Wei, Zhihua Xing, Hai Niu, Wen Huang
Retinal pigment epithelium (RPE) dysfunction is thought to increase the risk of the development and progression of diabetic retinopathy (DR), the leading cause of blindness. However, the molecular mechanism behind high glucose-induced RPE cell damage is still blurred. We reported that ARPE-19 exposed to 25mM glucose for 48h did not induce apoptosis, but senescence validated by SA-β-Gal staining, p21 expression and cell cycle distribution. High glucose also increased oxidant species that exerted a pivotal role in senescence, which could be relieved by the treatment with antioxidant N-acetylcysteine (NAC)...
October 16, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/30338672/physical-activity-and-eye-diseases-the-beijing-eye-study
#2
Ya Xing Wang, Wen Bin Wei, Liang Xu, Jost B Jonas
PURPOSE: To assess associations between the amount of physical activity and the prevalence of ocular diseases. METHODS: The participants of the population-based Beijing Eye Study underwent a detailed ophthalmological examination and an interview. Physical activity was assessed in a standardized questionnaire. RESULTS: Out of 3468 study participants, information on their physical activity was available for 3031 (87.4%) individuals (age: 64...
October 18, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/30337857/color-processing-in-zebrafish-retina
#3
REVIEW
April Meier, Ralph Nelson, Victoria P Connaughton
Zebrafish ( Danio rerio ) is a model organism for vertebrate developmental processes and, through a variety of mutant and transgenic lines, various diseases and their complications. Some of these diseases relate to proper function of the visual system. In the US, the National Eye Institute indicates >140 million people over the age of 40 have some form of visual impairment. The causes of the impairments range from refractive error to cataract, diabetic retinopathy and glaucoma, plus heritable diseases such as retinitis pigmentosa and color vision deficits...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/30337331/retinal-oxygen-saturation-is-an-independent-risk-factor-for-the-severity-of-diabetic-retinopathy
#4
Toke Bek, Einar Stefánsson, Sveinn Hákon Hardarson
BACKGROUND: The oxygen saturation in larger retinal vessels has been shown to increase with increasing diabetic retinopathy (DR) grade and to help predict the effect of antivascular endothelial growth factor treatment in patients with diabetic maculopathy. However, it is unknown to what extent the increased oxygen saturation co-varies with other risk factors and whether it is an independent risk factor for the severity of DR. METHODS: Seven hundred and twenty-two successive patients referred for specialist evaluation of diabetic retinopathy including retinal oximetry were studied...
October 18, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/30337079/the-region-of-interest-localization-for-glaucoma-analysis-from-retinal-fundus-image-using-deep-learning
#5
Anirban Mitra, Priya Shankar Banerjee, Sudipta Roy, Somasis Roy, Sanjit Kumar Setua
BACKGROUND AND OBJECTIVES: Retinal fundus image analysis without manual intervention has been rising as an imperative analytical approach for early detection of eye-related diseases such as glaucoma and diabetic retinopathy. For analysis and detection of Glaucoma and some other disease from retinal image, there is a significant role of predicting the bounding box coordinates of Optic Disc (OD) that acts as a Region of Interest (ROI). METHODS: We reframe ROI detection as a solitary regression predicament, from image pixel values to ROI coordinates including class probabilities...
October 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/30335815/comparison-of-methods-to-quantify-macular-and-peripapillary-vessel-density-in-optical-coherence-tomography-angiography
#6
Alessandro Rabiolo, Francesco Gelormini, Riccardo Sacconi, Maria Vittoria Cicinelli, Giacinto Triolo, Paolo Bettin, Kouros Nouri-Mahdavi, Francesco Bandello, Giuseppe Querques
PURPOSE: To compare macular and peripapillary vessel density values calculated on optical coherence tomography angiography (OCT-A) images with different algorithms, elaborate conversion formula, and compare the ability to discriminate healthy from affected eyes. METHODS: Cross-sectional study of healthy subjects, patients with diabetic retinopathy, and glaucoma patients (44 eyes in each group). Vessel density in the macular superficial capillary plexus (SCP), deep capillary plexus (DCP), and the peripapillary radial capillary plexus (RCP) were calculated with seven previously published algorithms...
2018: PloS One
https://www.readbyqxmd.com/read/30335521/increased-vertical-asymmetry-of-macular-retinal-layers-in-myopic-chinese-children
#7
Junjie Deng, Xiangui He, Bo Zhang, Shuyu Xiong, Jianfeng Zhu, Ling Wang, Mingjin Wang, Xun Xu
PURPOSE: The purpose of this project is to explore the changes in and factors associated with asymmetry between the superior and inferior hemiretina in children with different refractive levels. MATERIALS AND METHODS: A total of 2,964 children from twelve primary and middle schools in Shanghai, China, were included. The mean thickness of the GCL+ layer (ganglion cell layer+ inner plexiform layer), the GCC layer (ganglion cell complex, a combination of the retinal nerve fiber layer and the GCL+ layer), and the neural retina were measured according to the sectors defined by the Early Treatment of Diabetic Retinopathy Study (ETDRS) grid with swept-source optical coherence tomography...
October 18, 2018: Current Eye Research
https://www.readbyqxmd.com/read/30335004/bilateral-cataracts-as-the-first-manifestation-of-type-1-diabetes-mellitus-a-case-report
#8
Juan Wu, Haixia Zeng, Rui Xuan, Shuihong Lei, Jing Li, Xiaoyang Lai, Jianping Liu
RATIONALE: Cataracts can occur in children and adolescents with Type 1 Diabetes Mellitus who have poorly controlled glycemia. Here, we report a case of a 16-year-old female, who was diagnosed with bilateral cataracts, and genetic screening identified a mutation in the PRRC2A gene which is rarely reported. After surgery, retinopathy was found in this patient, combined with the published literature, we encourage that postoperative monitoring for retinal lesions during the follow-up visits should be conducted...
October 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30334924/effectiveness-of-en-bloc-removal-of-fibrinogen-rich-component-of-cystoid-lesion-for-the-treatment-of-cystoid-macular-edema
#9
Hisanori Imai, Keiko Otsuka, Akira Tetsumoto, Akiko Miki, Makoto Nakamura
PURPOSE: To introduce the methodology and outcomes of en bloc removal of the component of cystoid lesion during pars plana vitrectomy as a novel approach for the treatment of cystoid macular edema and show evidence that the component is an aggregation of fibrinogen by mass spectrometry analysis. METHODS: The surgical en bloc extraction of the component of cystoid lesion was performed for cystoid macular edemas secondary to diabetic retinopathy and retinal vein occlusion...
October 16, 2018: Retina
https://www.readbyqxmd.com/read/30334119/role-of-a-mydriasis-free-full-field-flicker-erg-device-in-the-detection-of-diabetic-retinopathy
#10
Mehmet Fatih Kağan Değirmenci, Sibel Demirel, Figen Batıoğlu, Emin Özmert
PURPOSE: To determine if the RETeval system can be used for the screening of diabetic retinopathy (DR) to provide early diagnosis. METHODS: The subjects were 42 diabetic patients selectively recruited by examination of their medical records to have varying severities of DR. The severity of DR was classified into four groups according to the International Clinical Diabetic Retinopathy Disease Severity Scale. Full-field electroretinograms (ERG) without mydriasis were obtained by the DR assessment protocol of the RETeval system...
October 17, 2018: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/30333091/serum-microrna-211-as-a-biomarker-for-diabetic-retinopathy-via-modulating-sirtuin-1
#11
He-Nan Liu, Nan-Jue Cao, Xun Li, Wei Qian, Xiao-Long Chen
Diabetic retinopathy (DR) is a progressive microvascular complication associated with diabetes, and remains the leading cause of preventable blindness worldwide. Recent studies have revealed that microRNAs (miRNAs) were involving in the physiological and pathophysiological processes of diabetes and its microvascular and macrovascular complications. The purpose of the current investigation is to identify the candidate miR-211 as a novel biomarker for occurrence and progression of DR in clinical study and experimental research...
October 14, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/30332969/molecular-and-pathophysiological-mechanisms-of-diabetic-retinopathy-in-relation-to-adhesion-molecules
#12
Salini Scaria Joy, Khalid Siddiqui
Diabetic retinopathy (DR) is considered as most common microvascular complication of diabetes affected by one in three people who are suffered for diabetes. Several pathophysiological mechanisms and adhesion molecules may play an etiologic role in the development of diabetes and its complications. The adhesion molecules located on both leucocytes and endothelial cells and considered as important molecules which can assessed the endothelial function. The functions of adhesion molecules involved in the cellular margination, slow rolling and transmigration of leukocytes...
October 16, 2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/30332687/correction-prevalence-and-progression-rate-of-diabetic-retinopathy-in-type-2-diabetes-patients-in-correlation-with-the-duration-of-diabetes
#13
Margarete Voigt, Sebastian Schmidt, Thomas Lehmann, Benjamin Köhler, Christof Kloos, Ulrich A Voigt, Daniel Meller, Gunter Wolf, Ulrich A Müller, Nicolle Müller
No abstract text is available yet for this article.
September 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/30332674/comparison-of-577-nm-multispot-and-standard-single-spot-photocoagulation-for-diabetic-retinopathy
#14
Renato M Passos, José Belucio-Neto, Camilla O Xavier, Eduardo A Novais, Mauricio Maia, Michel Eid Farah
OBJECTIVE: To compare two different laser strategies of panretinal photocoagulation for diabetic retinopathy. METHODS: Single-center, randomized study including 41 eyes treated with 577-nm multispot laser with a 20-ms pulse duration (group 1) or a 532-nm single-spot laser with a 100-ms pulse duration (group 2). The outcomes included best-corrected visual acuity (BCVA) and imaging changes at baseline, 6 and 12 months, laser parameters, and results of subjective pain analysis...
October 17, 2018: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/30328560/posterior-subtenon-infusion-of-triamcinolone-acetonide-as-adjunctive-treatment-to-panretinal-photocoagulation-using-pattern-scan-laser-for-diabetic-retinopathy
#15
Yutaka Yamada, Yoshihiro Takamura, Takehiro Matsumura, Masakazu Morioka, Makoto Gozawa, Masaru Inatani
PURPOSE: To estimate the effect of sub-Tenon's capsule triamcinolone acetonide injection (STTA) combined with panretinal photocoagulation (PRP) using pattern scan laser (PSL) for high risk non-proliferative diabetic retinopathy (NPDR), in terms of the inflammation and the progression of diabetic macular edema (DME). STUDY DESIGN: Retrospective comparative analysis. METHODS: NPDR patients who underwent PRP using PSL with (STTA+PSL group, n=24) or without (PSL group, n=19) pretreatment of STTA were enrolled...
October 17, 2018: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/30328477/pka-regulates-hmgb1-through-activation-of-igfbp-3-and-sirt1-in-human-retinal-endothelial-cells-cultured-in-high-glucose
#16
Li Liu, Paragi Patel, Jena J Steinle
OBJECTIVE AND DESIGN: Inflammation is a key component of a number of diseases, including diabetic retinopathy. We investigated the cellular pathway by which protein kinase A (PKA) inhibited high mobility group box 1 (HMGB1). METHODS: Primary human retinal endothelial cells (REC) were grown in normal glucose (5 mM) or high glucose (25 mM). Cells in high glucose were treated with exchange protein for cAMP 1 (Epac1) and IGFBP-3 siRNA. Additional cells in high glucose were treated with forskolin, a PKA agonist, and Epac1 siRNA...
October 17, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/30327785/five-year-predictors-of-insulin-initiation-in-people-with-type-2-diabetes-under-real-life-conditions
#17
Sandro Gentile, Felice Strollo, Francesca Viazzi, Giuseppina Russo, Pamela Piscitelli, Antonio Ceriello, Carlo Giorda, Piero Guida, Paola Fioretto, Roberto Pontremoli, Salvatore De Cosmo, The Amd-Annals Study Group
We performed a real-life analysis of clinical and laboratory parameters, in orally treated T2DM patients aiming at identifying predictors of insulin treatment initiation. Overall, 366955 patients (55.8% males, age 65 ± 11 years, diabetes duration 7 ± 8 years) were followed up between 2004 and 2011. Each patient was analyzed step-by-step until either eventually starting insulin treatment or getting to the end of the follow-up period. Patients switching to insulin showed a worse global risk profile, longer disease duration (10 ± 9 years vs...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/30327363/increased-prevalence-of-type-2-diabetes-related-complications-in-combined-type-2-diabetes-and-sickle-cell-trait
#18
Sarah C Skinner, Mor Diaw, Vincent Pialoux, Maïmouna Ndour Mbaye, Pauline Mury, Philomène Lopez, Delphine Bousquet, Fatou Gueye, Demba Diedhiou, Philippe Joly, Céline Renoux, Djiby Sow, Saliou Diop, Brigitte Ranque, Agnès Vinet, Abdoulaye Samb, Nicolas Guillot, Philippe Connes
OBJECTIVE: The prevalence of type 2 diabetes (T2D) is rapidly increasing in Sub-Saharan Africa, where sickle-cell trait (SCT) is also frequent. Although SCT is generally considered a benign condition, evidence suggests that SCT could exaggerate vascular dysfunction in T2D. However, it remains unclear whether SCT could increase the risk of the development of T2D complications. Therefore, this study was conducted to determine whether T2D complications were more prevalent among Senegalese individuals with SCT and T2D than among those with T2D only...
October 16, 2018: Diabetes Care
https://www.readbyqxmd.com/read/30326076/tractional-retinal-detachment-secondary-to-diabetic-retinopathy
#19
Daniel Q Li, Netan Choudhry
No abstract text is available yet for this article.
October 1, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/30326063/color-fundus-image-guided-artery-vein-differentiation-in-optical-coherence-tomography-angiography
#20
Minhaj Alam, Devrim Toslak, Jennifer I Lim, Xincheng Yao
Purpose: This study aimed to develop a method for automated artery-vein classification in optical coherence tomography angiography (OCTA), and to verify that differential artery-vein analysis can improve the sensitivity of OCTA detection and staging of diabetic retinopathy (DR). Methods: For each patient, the color fundus image was used to guide the artery-vein differentiation in the OCTA image. Traditional mean blood vessel caliber (m-BVC) and mean blood vessel tortuosity (m-BVT) in OCTA images were quantified for control and DR groups...
October 1, 2018: Investigative Ophthalmology & Visual Science
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