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Saroj Kumar Patnaik, Pradeep Kumar, Priya Yadav, Anubha Mittal, Sakshi Patel, Mahendra Pal Yadav, Tathagata Bose, Madhuri Kanitkar
Introduction: In last few years, several studies have revealed the remarkable stability of extracellular microRNAs (miRNAs) circulating in the blood or excreted in the urine and underscored their key importance as biomarkers of certain diseases. Since miRNA in urinary sediment is relatively stable and easily quantified, it has the potential to be developed as a biomarker for disease diagnosis and monitoring. Identification of serum and urinary levels of certain miRNAs may assist in the diagnosis and assessment of disease activity in patients with nephrotic syndrome (NS)...
2018: BMJ Paediatrics Open
E Cousin, A Ryckewaert, C de Jorna Lecouvey, A P Arnaud
INTRODUCTION: Since April 2015, the French Society of Pediatrics has encouraged suprapubic aspiration (SA) and urethral catheterization (UC) for urine collection in non-toilet-trained children suspected of having urinary tract infections (UTIs) and has tried to reduce the use of urine bag (UB). OBJECTIVE: To analyze the medical practices concerning urine collection methods used for non-toilet-trained children in pediatric emergency departments in France. METHODS: We conducted a descriptive medical practice study in October 2017...
December 13, 2018: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
Andrew C Nixon, Theodoros M Bampouras, Neil Pendleton, Sandip Mitra, Ajay P Dhaygude
BACKGROUND/AIMS: Frail patients with chronic kidney disease (CKD) have an increased hospitalisation and mortality rate. However, many popular frailty screening methods have not been validated in patients with CKD. This study evaluates the diagnostic accuracy of several frailty screening methods in patients with CKD G4-5 and those established on haemodialysis (G5D). METHODS: Ninety participants with CKD G4-5D were recruited from Nephrology Outpatient Clinics and 2 Haemodialysis Units between December 2016 and December 2017...
December 14, 2018: Nephron
Mikołaj Michno, Antoni Sydor, Marta Wałaszek, Władysław Sułowicz
A retrospective study was conducted among 498 patients with urinary tract infections (UTI) referred to our department from January 2013 to December 2015. This study was performed to evaluate the etiology of UTI and the antibiotic susceptibility profile of Escherichia coli ( E. coli ) as the main etiological factor in different age groups. Urine samples were examined using standard microbiological methods. Three hundred sixty-three samples (72.9%) were identified as E. coli , of which 29 (8.0%) can produce extended-spectrum β-lactamases (ESBL)...
2018: Polish Journal of Microbiology
Michi Recupero, Pierluigi Fulignati, Alessandro Naticchia, Silvia D'Alonzo, Francesca D'Ascenzo, Stefano Costanzi
ADH is a hormone secreted by neurohypophysis that plays different roles based on the target organ. At the renal level, this peptide is capable of causing electrolyte-free water absorption, thus playing a key role in the hydro-electrolytic balance. There are pathologies and disorders that jeopardize this balance and, in this field, ADH receptor inhibitors such as Vaptans could play a key role. By inhibiting the activation pathway of vasopressin, they are potentially useful in euvolemic and hypervolemic hypotonic hyponatremia...
December 2018: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
Gianfranco Carnevali, Santina Castellino, Pietro Claudio Giovanni Dattolo, Giovanni Giorgio Battaglia, Giuseppe Quintaliani
Nephrology continues to be in transition. While rates of kidney diseases and injury continue to rise, changes in the general health care system and the delivery of kidney care make it unclear how increases in need will be translated into demand for nephrologists. The changes in the delivery system also raise questions as to the future roles and career paths for nephrologists. There a major interrelated workforce issues to be watched closely : how many nephrologists are needed ? The supply of nephrologists does not reflect the distribution of patients with kidney diseases or the activity and job description related to end stage renal disease (ESRD) patients...
December 2018: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
Markos Kyriakos Tomidis Chatzimanouil, Louise Wilkens, Hans-Joachim Anders
BACKGROUND: In 2004, researchers reported that the number of nephrology clinical trials was low and that the reporting quality of such trials was suboptimal. Furthermore, the number or quality of preclinical kidney-related studies has not been systematically evaluated. METHODS: We performed a systematic review of randomized clinical trials published in 1966-2017 (listed in the Cochrane Library) and preclinical studies published in 1945-2017 (listed in PubMed). For reporting quality analysis, we evaluated the final main paper of 118 clinical trial reports and 135 preclinical studies published in leading journals in 1996, 2006, and 2016 on the basis of criteria from the widely used CONSORT and ARRIVE guidelines...
December 13, 2018: Journal of the American Society of Nephrology: JASN
Claudia D'Alessandro, Giorgina Barbara Piccoli, Massimiliano Barsotti, Serena Tassi, Domenico Giannese, Riccardo Morganti, Adamasco Cupisti
BACKGROUND: Sarcopenia is a widespread concern in chronic kidney disease (CKD) as well in elderly patients and is one of the main reasons why low-protein diets for this population are controversial. The aim of this study was to assess the prevalence and correlates of sarcopenia among elderly male patients affected by CKD followed up in an outpatient nephrology clinic, where moderate protein restriction (0.6⁻0.8 g/Kg/day) is routinely recommended to patients in CKD stage 3b-5 not on dialysis...
December 10, 2018: Nutrients
Wei Zhang, Baohuan Cai, Xiaole Zhang, Jianhua Zhou, Liru Qiu, Huiming Yi
Vesicoureteral reflux (VUR) is one of the most common urinary tract anomalies in children. It has been reported that VUR may be associated with reflux nephropathy. Ultrasound contrast-enhanced voiding urosonography (CeVUS) has become a routine diagnostic method for VUR in a number of European countries; however, it is not widely used in China. The aim of the present study was to analyze the clinical application and evaluate the safety of CeVUS as a diagnostic tool for VUR in children in order to establish a standardized operating procedure for CeVUS in pediatric VUR in China...
December 2018: Experimental and Therapeutic Medicine
Elisa J Gordon, Catherine Wicklund, Jungwha Lee, Richard R Sharp, John Friedewald
INTRODUCTION: There is debate over whether Apolipoprotein L1 (APOL1) gene risk variants contribute to African American (AA) live donors' (LD) increased risk of kidney failure. Little is known about factors influencing physicians' integration of APOL1 genetic testing of AA LDs into donor evaluation. DESIGN: We conducted a cross-sectional survey, informed by Roger's Diffusion of Innovations theory, among nephrology and surgeon members of the American Society of Nephrology, American Society of Transplantation, and American Society of Transplant Surgeons about their practices of and attitudes about APOL1 genetic testing of AA potential LDs...
December 13, 2018: Progress in Transplantation
Panagiotis I Georgianos, Rajiv Agarwal
No abstract text is available yet for this article.
December 12, 2018: Nephrology, Dialysis, Transplantation
Carlos Terra, Ângelo Zambam de Mattos, Gustavo Pereira, Alberto Queiroz Farias, Mario Kondo, Angelo Alves de Mattos, José Eymard Moraes de Medeiros Filho, Edna Strauss, Fábio Ricardo Dantas Dutra, Marcelo Mazza, Edmundo Pessoa Lopes, Tiago Sevá Pereira, Leonardo Lucca Schiavon, Roberto José de Carvalho Filho, Cláudia Fagundes, Paulo Lisboa Bittencourt
Acute kidney injury is a common complication of cirrhosis, occurring in up to 20% of patients hospitalized with cirrhosis. This field is rapidly changing, with significant advances in classification, biomarkers and therapy over the last few years. On the behalf of the Brazilian Society of Hepatology, a panel of experts in Hepatology and Nephrology reviewed published evidence to integrate findings and develop the recommendations presented in this manuscript.
July 2018: Arquivos de Gastroenterologia
Yexin Liu, Yan Zhang, Di Liu, Xia Tan, Xiaofang Tang, Fan Zhang, Ming Xia, Guochun Chen, Liyu He, Letian Zhou, Xuejing Zhu, Hong Liu
BACKGROUND/AIMS: There is an increasing risk of end-stage renal disease (ESRD) among Asian people with immunoglobulin A nephropathy (IgAN). A computer-aided system for ESRD prediction in Asian IgAN patients has not been well studied. METHODS: We retrospectively reviewed biopsy-proven IgAN patients treated at the Department of Nephrology of the Second Xiangya Hospital from January 2009 to November 2013. Demographic and clinicopathological data were obtained within 1 month of renal biopsy...
December 7, 2018: Kidney & Blood Pressure Research
Inkyong Hur, Yong Kyu Lee, Kamyar Kalantar-Zadeh, Yoshitsugu Obi
BACKGROUND: Residual kidney function (RKF) is often expected to inevitably and rapidly decline among hemodialysis patients and, hence, has been inadvertently ignored in clinical practice. The importance of RKF has been revisited in some recent studies. Given that patients with end-stage renal disease now tend to initiate maintenance hemodialysis therapy with higher RKF levels, there seem to be important opportunities for incremental hemo-dialysis by individualizing the dose and frequency according to their RKF levels...
December 11, 2018: Cardiorenal Medicine
Julia Thumfart, Dirk Bethe, Sarah Wagner, Wolfgang Pommer, Cornelia Rheinländer, Dominik Müller
AIM: Children and adolescents with end stage renal disease face a high morbidity and mortality. Palliative care provides a multidisciplinary approach to reduce disease burden and improve quality of life. This study evaluated concepts and current structures of palliative care from the perspective of a multidisciplinary paediatric nephrology team including physicians, nurses and psychosocial health professionals. METHODS: Evaluation was done by an online survey sent to the members of the German Society of Nephrology and to the nurse managers of German paediatric dialysis centres between April 9th 2018 and May 31th 2018...
December 11, 2018: Acta Paediatrica
Akhtar Ashfaq
Of late, fewer residents are choosing nephrology as a career. Contributing factors may include lack of prestige, uncertain potential of future income, and poor work-life balance. Some current nephrologists are considering transitioning to another career for similar reasons. For those who decide that practicing nephrology is no longer appealing, there are many available avenues where they can use their nephrology expertise and still have a successful future. A leadership role in the pharmaceutical industry is a potentially attractive and viable option to nephrologists who are ready to transition to a different career...
November 2018: Advances in Chronic Kidney Disease
Wendy Weinstock Brown, Sharon Anderson
Women and men tend to take different paths to leadership, with men being more intentional. When women do undertake leadership activities, they tend to be surprised by how much they enjoy it. Women's leadership styles tend to be more collaborative and inclusive. Women are used to multitasking and tend to persist under difficult circumstances. The nephrology manpower crisis affects both men and women, although some of the drivers are different. There is a persistent and well-known pay disparity between men and women physicians that many have tried to address without consistent success...
November 2018: Advances in Chronic Kidney Disease
Belinda Jim, Jerry Yee
Mentorship has always been important in medicine. In fact, one can argue that that is how doctors are trained. Moreover, mentorship has been proven to preserve and elevate those who wish to pursue academic medicine. In nephrology, mentorship has become paramount, as interest in the field has declined during this decade. In this article, we will delineate how mentorship impacts physician careers, describe different types of mentors and their characteristics, and summarize responsibilities of mentors and mentees...
November 2018: Advances in Chronic Kidney Disease
Robert E Blaser, Dale Singer, Rebecca J Schmidt
As a specialty and profession, nephrology has deep roots in the arenas of advocacy and public policy, with nephrologists playing a significant role in garnering legislative attention on the needs of patients with end-stage renal disease. The depth of experiences and unique perspectives of nephrologists and sharing our positions with legislators, regulators, and decision makers are central to achieving the Triple Aim for patients with kidney disease. Advocacy and public policy are conducted externally as well as internally to the House of Medicine and shape the future of kidney care and nephrology practice...
November 2018: Advances in Chronic Kidney Disease
Nelson Kopyt, Ravindra Bollu
Private practice is entering an era of diminishing reimbursement and increasing overhead associated with federally mandated payment reforms resulting in a need to move from the traditional fee-for-service to a value-based model, changes that place financial and organizational strain on nephrology practices. In addition, the changing geopolitical scene is one of mergers and consolidation of health care networks, which in turn are developing their own insurance plans or partnering with commercial payers. The new landscape will require the leadership of a private nephrology practice to vigilantly monitor and adapt to these changes for success...
November 2018: Advances in Chronic Kidney Disease
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