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Suresh Chandra Dash, Sanjay Kumar Agarwal, Ansuman Panigrahi, Jayanti Mishra, Debadutta Dash
Objectives: The study was designed to find out frequency of (i) Diabetes mellitus (DM) as a cause Chronic Kidney Disease (CKD), (ii) Association between diabetic-CKD (diabetic patients who subsequently developed CKD as complication), hypertension (HT) and obesity. Further assessment was made to (iii) Identify percentage of diabetics attending medical and nephrology OPD had prior testing for proteinuria and or creatinine. Methods: After ethical consideration this prospective observational study was conducted on consecutive 6175 patients who gave consent to participate in two major referral hospitals one in Delhi and other in Bhubaneswar (BBSR)...
March 2018: Journal of the Association of Physicians of India
Alyssa A Riley, Mary Watson, Carolyn Smith, Danielle Guffey, Charles G Minard, Helen Currier, Ayse Akcan Arikan
BACKGROUND: To evaluate changes in population characteristics and outcomes in a large single-center pediatric patient cohort treated with continuous renal replacement therapy (CRRT) over a 10 year course, coincident with multiple institutional practice changes in CRRT delivery. METHODS: A retrospective cohort study with comparative analysis of all patients treated from 2004 to 2013 with CRRT in the neonatal, pediatric, and cardiovascular intensive care units within a free-standing pediatric tertiary care hospital...
October 19, 2018: BMC Nephrology
P Ramachandran, R Morcus, M Tahir, I Onukogu, B Spinowitz, Jen C Wang
BACKGROUND: Lung cancer is among the top causes of cancer-related mortality in men and is the second most common cancer after breast cancer in women. There are approximately 234,030 new cases of lung cancer and 154,050 deaths from lung cancer in 2018 as per the latest American Cancer Society's report. Alectinib, a more potent orally active tyrosine kinase inhibitor which was approved by the US Food & Drug Administration for anaplastic lymphoma kinase-positive lung adenocarcinoma, has been shown to have a reasonable safety profile when compared with other anaplastic lymphoma kinase-targeted therapy...
October 19, 2018: Journal of Medical Case Reports
Julie Klein, Joost P Schanstra
Preclinical animal models are extensively used in nephrology. In this review we have assessed the utility of performing proteome analysis of kidney tissue or urine in such models and transfer of the results to human application. Analysis of the literature identified 68 relevant publications. Pathway analysis of the reported proteins clearly indicated links with known biological processes in kidney disease providing validation of the observed changes in the preclinical models. However, we found that although most studies focused on the identification of early markers of kidney disease or prediction of its progression, none of the identified makers has made it to substantial validation in the clinic or at least in human samples...
October 18, 2018: Proteomics. Clinical Applications
Yasuhiro Onishi, Haruhito A Uchida, Takeuchi Hidemi, Yuki Kakio, Hitoshi Sugiyama, Jun Wada, Noriaki Shimada, Hironobu Tokumasu, Masaki Fukushima, Kenichiro Asano
AIM: Deteriorated health-related quality of life (HRQOL) is associated with increased risk for death in both CKD and ESRD patients, however, the impact of HRQOL on CKD progression is not well investigated. METHODS: We aimed to evaluate the association between HRQOL and CKD progression in Japanese patients with CKD. One hundred and three outpatients who visited the department of nephrology at our hospital (mean eGFR; 32.1±11.2 mL/min/1.73m2 ) between April 2007 and March 2012 were enrolled in this study...
October 17, 2018: Nephrology
Ryo Koda, Masafumi Tsuchida, Noriaki Iino, Ichiei Narita
A 68-year-old man with type 2 diabetes mellitus and chronic hepatitis B infection was referred to the nephrology department before planned surgery for hepatocellular carcinoma. He had been receiving low-dose adefovir dipivoxil (ADV) for 11 years. Laboratory findings revealed impaired re-absorption in the proximal renal tubules. He had been diagnosed with diabetic kidney disease and osteomalacia due to vitamin D deficiency; thus, ADV was not discontinued until he was referred to us. In this case, concomitant diabetes mellitus and vitamin D deficiency might have prevented the early diagnosis of ADV-induced Fanconi syndrome...
October 17, 2018: Internal Medicine
Simon Sawhney, Monica Beaulieu, Corri Black, Ognjenka Djurdjev, Gabriela Espino-Hernandez, Angharad Marks, David J McLernon, Zainab Sheriff, Adeera Levin
Background: Outcomes after acute kidney injury (AKI) are well described, but not for those already under nephrology clinic care. This is where discussions about kidney failure risk are commonplace. We evaluated whether the established kidney failure risk equation (KFRE) should account for previous AKI episodes when used in this setting. Methods: This observational cohort study included 7491 people referred for nephrology clinic care in British Columbia in 2003-09 followed to 2016...
October 15, 2018: Nephrology, Dialysis, Transplantation
Peter W Crooks, Christopher O Thomas, Amy Compton-Phillips, Wendy Leith, Alvina Sundang, Yi Yvonne Zhou, Linda Radler
OBJECTIVES: To assess the association between optimal end-stage renal disease (ESRD) starts and clinical and utilization outcomes in an integrated healthcare delivery system. STUDY DESIGN: Retrospective observational cohort study in 6 regions of an integrated healthcare delivery system, 2011-2013. METHODS: Propensity score techniques were used to match 1826 patients who experienced an optimal start of renal replacement therapy (initial therapy of hemodialysis via an arteriovenous fistula or graft, peritoneal dialysis, or pre-emptive transplant) to 1826 patients who experienced a nonoptimal start (hemodialysis via a central venous catheter)...
October 1, 2018: American Journal of Managed Care
Lucas De Lavallaz, Carlos G Musso
INTRODUCTION: Chronobiology studies the phenomenon of rhythmicity in living organisms. The circadian rhythms are genetically determined and regulated by external synchronizers (the daylight cycle). Several biological processes involved in the pharmacokinetics and pharmacodynamics of drugs are subjected to circadian variations. Chronopharmacology studies how biological rhythms influence pharmacokinetics, pharmacodynamics, and toxicity, and determines whether time-of-day administration modifies the pharmacological characteristics of the drug...
October 15, 2018: International Urology and Nephrology
Farshid Kompani, Ehsan Valavi, Parisa Amuri, Neda Mohtasham
OBJECTIVE: Considering the predictive role of the relatively low urinary citrate for stone formation, especially in hypercalciuric patients, this study is aimed at comparing urine calcium to citrate (Ca/Cit) ratio in 3 groups of children, including patients with idiopathic hypercalciuria with and without renal stone as well as the healthy children. METHODS: This study was carried out on 96 children (2 to 12 years old) referred to a pediatric nephrology clinic in the city of Ahvaz, Southwest Iran...
October 12, 2018: Journal of Renal Nutrition
Fehime Kara Eroglu, Evrim Kargın Çakıcı, Gökçe Can Gür, Tülin Güngör, Fatma Yazılıtaş, Eda Didem Kurt-Sukur, Evra Celikkaya, Çiğdem Üner, Emin Çakmakçı, Mehmet Bülbül
INTRODUCTION: Increased ultrasonography (US) use has been correlated with an increased incidence of pediatric renal cysts. For simple and stage II cysts, the malignancy risk is low in adulthood, no follow-up is recommended; but there is no consensus on childhood management. Since pediatric renal cysts may be manifestations of hereditary cystic diseases, a different approach and follow-up should be taken for these patients. Herein we present the clinical characteristics and follow-up data of our pediatric patients with simple and stage II renal cysts...
October 15, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
Maryam Mozaffar, Shahrzad Shahidi, Marjan Mansourian, Shirinsadat Badri
Objective: Organ transplant recipients receive immunosuppressive regimens to prevent transplant rejection, which put them at increased risk for opportunistic infections like cytomegalovirus (CMV). Ganciclovir and Valganciclovir are mostly used to prevent or treat CMV. Any incorrect use of the drug may have serious consequences for patients. In this study, the outcome of transplant recipients was assessed in relation to the optimal or suboptimal use of Ganciclovir or Valganciclovir. Methods: This study was performed on 148 hospitalized patients who received Ganciclovir or Valganciclovir in the nephrology and kidney transplantation departments of our university hospitals, from March 2012 to December 2016...
2018: Journal of Transplantation
Pilar Arrizabalaga, Mónica Gómez, Ignacio Menacho, Lidia Pallisa, Vanesa Jorge, Esteban Poch
The coordination between nephrology and primary care is well documented in the management of chronic kidney disease (CKD), but the real impact is uncertain. OBJECTIVE: To evaluate the efficiency of an outpatient nephrology program (ONP) implanted progressively over the course of 10 years regarding the demand for CKD care in the Integral Health Area of Barcelona Esquerra, accounting for 524,395 inhabitants, which is more than a third of the population of Barcelona. MATERIAL AND METHODS: The number and age of the new referrals to nephrology between 2004 and 2014 were identified and a referral index (RI) was established between the number of new referrals and the estimated prevalence of CKD in the population treated, based on the implementation of the ONP...
October 11, 2018: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
Haridian Sosa Barrios, José Ibeas López, Ramón Roca Tey, Manuel Ceballos Guerrero, Angels Betriu Bars, Ignacio Cornago Delgado, Manuel Lanuza Luengo, Vicente Paraíso Cuevas, Pedro L Quirós Ganga, Maite E Rivera Gorrín
No abstract text is available yet for this article.
September 2018: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
Allan K Grill, Scott Brimble
OBJECTIVE: To help primary care providers, both family physicians and nurse practitioners, identify, detect, and manage patients with and at risk of chronic kidney disease (CKD), as well as outline criteria for appropriate referral to nephrology. SOURCES OF INFORMATION: Published guidelines on the topic of CKD and its comorbidities were reviewed. A MEDLINE search was conducted using the MeSH terms chronic renal insufficiency, family practice, and primary health care ...
October 2018: Canadian Family Physician Médecin de Famille Canadien
Aiqun Chen, Ying Sun, Ju Cui, Ban Zhao, Haitao Wang, Xianguang Chen, Yonghui Mao
BACKGROUND: Previous clinical studies found inconsistent relationship between circulating sclerostin levels and treatment outcome in patients undergoing maintenance hemodialysis (MHD). Therefore, this study aimed to assess the associations of sclerostin with carotid artery atherosclerosis and all-cause mortality in Chinese patients undergoing MHD. METHODS: This retrospective study assessed 84 patients undergoing MHD at the Nephrology Department of Beijing Hospital from January to April 2012, with a median follow-up of 61...
October 12, 2018: BMC Nephrology
A A Zulfiqar, A Hajjam, S Talha, M Hajjam, J Hajjam, S Ervé, E Andrès
Telemedicine is now in vogue, being deployed through computer and communication tools in various health fields, such as diabetology, nephrology, dermatology, neurology, and cardiology. With population ageing, geriatrics is coming into sharp focus. Telemedicine practices differ for home-based or institutionalized patients in long-term care homes. We take a look at telemedicine projects in France concerning the elderly.
2018: Current Gerontology and Geriatrics Research
Rasmus Ehren, Marcus R Benz, Jorg Doetsch, Alexander Fichtner, Jutta Gellermann, Dieter Haffner, Britta Höcker, Peter F Hoyer, Bärbel Kästner, Markus J Kemper, Martin Konrad, Steffen Luntz, Uwe Querfeld, Anja Sander, Burkhard Toenshoff, Lutz T Weber
INTRODUCTION: Idiopathic nephrotic syndrome is the most common glomerular disease in childhood with an incidence of 1.8 cases per 100 000 children in Germany. The treatment of the first episode implies two aspects: induction of remission and sustainment of remission. The recent Kidney Disease Improving Global Outcomes, American Academy of Pediatrics and German guidelines for the initial treatment of the first episode of a nephrotic syndrome recommend a 12-week course of prednisone. Despite being effective, this treatment is associated with pronounced glucocorticoid-associated toxicity due to high-dose prednisone administration over a prolonged period of time...
October 10, 2018: BMJ Open
Nicholas Wettersten, Alan S Maisel, Dinna N Cruz
Although the field of oncology has made significant steps toward individualized precision medicine, cardiology and nephrology still often use a "one size fits all" approach. This applies to the intersection of the heart-kidney interaction and the cardiorenal syndrome as well. Recent studies have shown that the prognostic implications of worsening renal function (WRF) in acute heart failure are variable; thus, there is a need to differentiate the implications of WRF to better guide precise care. This may best be performed with biomarkers that can give the clinician a real-time evaluation of the physiologic state at the time of developing WRF...
September 2018: Advances in Chronic Kidney Disease
Sihua Huang, Xixin Wu
OBJECTIVE: To compare the estimated glomerular filtration rates (eGFR) by five formulas based on serum creatinine (SCr), and to explore the diagnostic efficacy of full age spectrum (FAS) equation based on SCr for renal insufficiency in patients with chronic kidney disease (CKD). METHODS: 2 219 patients with CKD admitted to department of nephrology of Guangdong Provincial Second People's Hospital from December 2015 to January 2018 were enrolled. According to the diagnostic criteria of kidney disease outcomes quality initiative (K/DOQI), patients were divided into CKD 1-5 stages...
September 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
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