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Kamel Charradi, Mohamed Mahmoudi, Takwa Bedhiafi, Khawla Jebari, Michèle Veronique El May, Ferid Limam, Ezzedine Aouani
Grape seed powder (GSP) contains high amount of bioactive polyphenols usually used as nutritional supplement or food preservatives due to their antioxidant and scavenging properties. The purpose of the present work was to evaluate the safety of increasing dosage GSP (w/w) of 0.5%, 5%, 10% and 20% corresponding to 0.4, 4, 8 and 16 g/kg bw respectively, when administered sub-chronically to Wistar rats in a 2 month-repeated dosing oral toxicity trial. Overally GSP had no effect on food intake, decreased body weight gain without affecting brain, liver, heart or kidney relative weight...
August 13, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Anselm Chi-Wai Lee
INTRODUCTION: Childhood immune thrombocytopenia (ITP) remains a diagnosis of exclusion when isolated thrombocytopenia is not part of another disease process. In practice, the diagnosis of ITP can only be confirmed when thrombocytopenia resolves or is excluded after the recognition of a primary cause. METHODS: The records of 87 consecutive children with isolated thrombocytopenia seen over a nine-year period in a private paediatric haematology practice were reviewed retrospectively...
July 2018: Singapore Medical Journal
Beatriz Pelegrina-Cortés, Laura M Bermejo, Bricia López-Plaza, Samara Palma-Milla, Natalia García-Vázquez, Carmen Gómez-Candela
Individualized parenteral nutrition is the most specialized type of nutritional support in the hospital setting. The composition and prescribing patterns for parenteral nutrition have evolved due to new emerging scientific evidence. In the last few years, there has been a tendency to increase the nitrogen and lipid content and decrease the carbohydrate content. To assess the prescribing pattern in a tertiary referral hospital in Spain, the nutritional composition of individualized parenteral nutrition was evaluated retrospectively from January to December of 2016...
August 13, 2018: Nutrients
J A Brett, S A Johnson, D R M Cameron, C R Lane, M Easton, A van Diemen, B Sutton, A L Bull, M J Richards, L J Worth
Carbapenemase-producing Enterobacteriaceae (CPE) infections are increasingly reported in Australian hospitals, but prevalence is unknown. In 2016, Victorian hospitals conducted CPE point-prevalence surveys (PPS) in high-risk wards (intensive care, haematology, transplant). Forty-three hospitals performed 134 surveys, with 1839/2342 (79%) high-risk patients screened. Twenty-four surveys were also performed in other wards. Inability to obtain patient consent was the leading reason for non-participation. In high-risk wards, no CPE cases were detected; three cases were identified in other wards...
August 10, 2018: Journal of Hospital Infection
Olwen Amy Westerland, Guy Pratt, Majid Kazmi, Inas El-Najjar, Matthew Streetly, Kwee Yong, Monica Morris, Rakesh Mehan, Martin Sambrook, Margaret Hall-Craggs, David Silver, Vicky Goh
OBJECTIVES: Cross-sectional imaging is now recommended by the National Institute for Health and Care Excellence (NICE) for patients with suspected and newly diagnosed myeloma instead of skeletal survey. The objectives of this study were: (1) To evaluate compliance of current UK imaging practice with reference to national NICE best-practice clinical guidelines for plasma cell malignancies. (2: To identify factors which may influence diagnostic imaging choices. METHODS: We conducted a national online survey to assess compliance with guidelines and to identify challenges to implementation (endorsed by Myeloma UK, UK Myeloma Forum and the British Society of Skeletal Radiologists)...
August 13, 2018: British Journal of Radiology
Carina Intke, Sini Korpelainen, Sari Hämäläinen, Matti Vänskä, Irma Koivula, Esa Jantunen, Kari Pulkki, Auni Juutilainen
OBJECTIVE: The study aim was to compare the performance of interleukin-1 receptor antagonist (IL-1Ra) to C-reactive protein (CRP) and procalcitonin (PCT) in early prediction of the clinical course of febrile neutropenia. METHODS: The study population consisted of 86 consecutive patients with febrile neutropenia who received intensive chemotherapy for haematological malignancy between November 2009 and November 2012 at the adult haematology ward of Kuopio University Hospital...
August 12, 2018: European Journal of Haematology
Markus Ruhnke, Gerhard Behre, Dieter Buchheidt, Maximilian Christopeit, Axel Hamprecht, Werner Heinz, Claus-Peter Heussel, Marius Horger, Oliver Kurzai, Meinolf Karthaus, Jürgen Löffler, Georg Maschmeyer, Olaf Penack, Christina Rieger, Volker Rickerts, Jörg Ritter, Martin Schmidt-Hieber, Nikolai Schuelper, Stefan Schwartz, Andrew Ullmann, Jörg-Janne Vehreschild, Marie von Lilienfeld-Toal, Thomas Weber, Hans-H Wolf
Invasive fungal diseases (IFD) are a primary cause of morbidity and mortality in patients with haematological malignancies. These infections are mostly life-threatening and an early diagnosis and initiation of appropriate antifungal therapy are essential for the clinical outcome. Most commonly, Aspergillus and Candida species are involved. However, other Non-Aspergillus moulds are increasingly identified in case of documented IFD. For definite diagnosis of IFD, a combination of diagnostic tools have to be applied, including conventional mycological culture and non-conventional microbiological tests such as antibody / antigen and molecular tests, as well as histopathology and radiology...
August 11, 2018: Mycoses
Christopher Imokhuede Esezobor, Patricia Akintan, Uche Nwaogazie, Edna Akinwunmi, Edamisan Temiye, Adebola Akinsulie, Rasheed Gbadegesin
BACKGROUND: No large studies have examined the prevalence of enuresis, its various forms and risk factors in children with sickle cell anaemia (SCA) in Sub-Saharan Africa using standardised definitions. We determined age and gender-specific prevalence of enuresis and compared the nature of enuresis in children with and without SCA. We also identified predictors of enuresis in children with SCA. METHODS: Caregivers of children with SCA attending a tertiary centre haematology clinic in Nigeria were interviewed using a questionnaire...
2018: PloS One
Muhammad Farhan Sohail, Hafiz Shoaib Sarwar, Ibrahim Javed, Akhtar Nadhman, Syed Zajif Hussain, Hamid Saeed, Abida Raza, Nadeem Irfan Bukhari, Irshad Hussain, Gul Shahnaz
Polymeric nanomaterials, hybridized with lipid components, e.g. phosphocholine or fatty acids, are currently being explored for efficient nano-platforms for hydrophobic drugs. However, their toxicology and toxicokinetics need to be established before enabling their clinical potential. The aim of this study was to investigate the toxicological profile of thiomer enveloped hybrid nanoliposomes (ENLs) and bare nanoliposomes (NLs), loaded with docetaxel (DTX) hydrophobic drug, biocompatible nano-carriers for therapeutic cargo...
November 1, 2017: Toxicology Research
Johan A Maertens, Corrado Girmenia, Roger J Brüggemann, Rafael F Duarte, Christopher C Kibbler, Per Ljungman, Zdenek Racil, Patricia Ribaud, Monica A Slavin, Oliver A Cornely, J Peter Donnelly, Catherine Cordonnier
The European Conference on Infections in Leukaemia (ECIL) updated its guidelines on antifungal prophylaxis for adults using the grading system of IDSA. The guidelines were extended to provide recommendations for other haematological diseases besides AML and recipients of an allogeneic haematopoietic stem cell transplantation (HSCT). Posaconazole remains the drug of choice when the incidence of invasive mould diseases exceeds 8%. For patients undergoing remission-induction chemotherapy for AML and myelodysplastic syndrome (MDS), fluconazole can still offer an alternative provided it forms part of an integrated care strategy that includes screening with biomarkers and imaging...
August 1, 2018: Journal of Antimicrobial Chemotherapy
F W Thielen, H M Blommestein, L E M Oosten, F G Calkoen, A C Lankester, J J Zwaginga, K Le Blanc, A Redondo, F Sánchez-Guijo, M Algeri, F Locatelli, W E Fibbe, C A Uyl-de Groot
OBJECTIVE: No standard second-line treatment exists for acute graft-versus-host disease steroid-refractory (SR-aGvHD) and long-term outcomes remain poor. Mesenchymal stromal cells (MSC) have been evaluated as treatment but no disease model (DM) exists that integrates and extrapolates currently available evidence. The aim to develop such a DM to describe the natural history of SR-aGvHD and to predict long-term outcomes. METHOD: The DM was developed in collaboration with experts in haematology-oncology...
August 6, 2018: European Journal of Haematology
M Martini, F Paluan
Between nineteenth and twentieth centuries, medicine knew the beginning of an incessant development: the birth of new medical specialties (radiology, for instance), the introduction of new devices in medical and surgical wards, and the discovery of bacteria represented important milestones in that first historical period. The Medical School of the University of Genoa, head by Edoardo Maragliano, full professor of internal medicine, took on a relevant role in the battle against tuberculosis, through the experimental demonstration of the existence of an immune response against M...
June 2018: Journal of Preventive Medicine and Hygiene
Abubakar Danmaigoro, Gayathri Thevi Selvarajah, Mohd Hezmee Mohd Noor, Rozi Mahmud, Md Zuki Abu Bakar
Doxorubicin (DOX) is a potent anticancer agent with cytotoxic effects which limit its clinical usage. This effect is due to its nonselective nature causing injury to the cells as a result of reactive free oxygen radical's release. Cockleshell-derived calcium carbonate nanoparticle (CS-CaCO3 NP) is a pH-responsive carrier with targeted delivery potentials. This study aimed at evaluating the toxicity effects of repeated dose administration of DOX-loaded CS-CaCO3 NP in healthy dogs. Fifteen dogs with an average body weight of 15 kg were randomized equally into 5 groups...
2018: Advances in Pharmacological Sciences
Cécile Aubron, Andrew W J Flint, Yves Ozier, Zoe McQuilten
BACKGROUND: Platelets (PLTs) are usually stored for up to 5 days prior to transfusion, although in some blood services the storage period is extended to 7 days. During storage, changes occur in both PLT and storage medium, which may lead to PLT activation and dysfunction. The clinical significance of these changes remains uncertain. METHODS: We performed a systematic review to assess the association between PLT storage time and clinical or transfusion outcomes in patients receiving allogeneic PLT transfusion...
August 5, 2018: Critical Care: the Official Journal of the Critical Care Forum
The Lancet Haematology
No abstract text is available yet for this article.
August 2018: Lancet Haematology
Kim Klein, Henrik Hasle, Jonas Abrahamsson, Barbara De Moerloose, Gertjan J L Kaspers
Prevention of infections is of obvious relevance in paediatric patients with acute myeloid leukaemia (AML). However, recommendations are often non-specific and supported by low-quality evidence, resulting in divergent infection preventive regimens. Using a web-based survey, we investigated the infection prophylaxis guidelines of 22 paediatric AML study groups affiliated to the international Berlin-Frankfürt-Münster study group. In order to evaluate differences in daily practice among hospitals, representatives (n = 27) from the Nordic Society for Paediatric Haematology and Oncology-Dutch-Belgium-Hong Kong - AML study group participated in a slightly modified survey...
August 3, 2018: British Journal of Haematology
Lauren Atkins, Belinda Steer, Hannah Ray, Nicole Kiss
PURPOSE: Effective, timely and evidence-based nutritional management is important in patients receiving autologous haematopoietic stem cell transplant (HSCT) to prevent the negative consequences of developing malnutrition. This study describes a robust process for development and implementation of an evidence-based nutrition care pathway for HSCT patients in a tertiary cancer centre. METHODS: A comprehensive review of the literature was completed to identify relevant articles and evidence-based guidelines to inform the development of the pathway...
August 2, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
(no author information available yet)
No abstract text is available yet for this article.
August 2018: Clinical Medicine: Journal of the Royal College of Physicians of London
María-Aránzazu Martínez, Irma Ares, María-Rosa Martínez-Larrañaga, Arturo Anadón, Victor Casado, Luis Vazquez, Diana Martin, Guillermo Reglero, Carlos Torres
Phosphatidyl-hydroxytyrosol, a carrier of hydroxytyrosol under the form of phospholipid with high antioxidant capacity, is being actively studied as a potential ingredient of functional foods and supplements. To support the safety, phosphatidyl-hydroxytyrosol has been examined in an acute and in a 28-day repeated dose oral toxicity studies in rats. Phosphatidyl-hydroxytyrosol administered in a single oral gavage dose of 2000 mg/kg of body weight (bw) resulted in no adverse events or mortality. In addition, phosphatidyl-hydroxytyrosol administered as a daily dose of 2000 mg/kg bw for 28 days by gavage resulted in no adverse events or mortality...
July 25, 2018: Food and Chemical Toxicology
Nicole Engel, Alicia Rovo, Manuela Badoglio, Myriam Labopin, Grzegorz W Basak, Yves Beguin, Denis Guyotat, Per Ljungman, Arnon Nagler, Anton Schattenberg, Thomas Schroeder, Wilfried Schroyens, Johanna Tischer, Gerard Socie, Hans-Jochem Kolb, Andre Tichelli, Nina Salooja, Rafael F Duarte
Donor cell leukaemia (DCL) is a rare complication of allogeneic haematopoietic cell transplantation (HCT). We have investigated the prevalence and outcome of donor cell haematology malignancies within centres registered with the European Society of Blood and Marrow transplantation (EBMT). We have sought to identify risk factors to shed light on the pathogenesis of DCL as a model for leukaemogenesis. DCL cases were identified by questionnaire and a follow-up questionnaire requested detailed data. Control subjects from the EBMT registry who had not developed DCL were used for a matched pair analysis to identify risk factors...
July 26, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
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