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Victoria Strong, Torsten Möller, Ann-Sofie Tillman, Stefan Träff, Louise Guevara, Mike Martin, Sharon Redrobe, Kate White
OBJECTIVE: To characterize the cardiopulmonary characteristics of two different anaesthetic protocols (tiletamine/zolazepam ± medetomidine) and their suitability for the immobilization of healthy chimpanzees undergoing cardiac assessment. STUDY DESIGN: Prospective, clinical, longitudinal study. ANIMALS: Six chimpanzees (Pan troglodytes) aged 4-16 years weighing 19.5-78.5 kg were anaesthetized on two occasions. METHODS: Anaesthesia was induced with tiletamine/zolazepam (TZ) (3-4 mg kg-1 ) or tiletamine/zolazepam (2 mg kg-1 ) and medetomidine (0...
August 23, 2018: Veterinary Anaesthesia and Analgesia
Anthi-Marina Markantonatou, Konstantinos Samaras, Evangelia Yannaki, Evaggelia Zachrou, Timoleon-Achilleas Vyzantiadis
Aspergillus galactomannan immunoassay is a main diagnostic and monitoring tool in medical mycology. However, the specificity of the method can be skewered by the presence of several other fungi. Trying to diagnose a possible fungal infection of the lower respiratory tract in a haematology patient, it appeared that the fungus Trichoderma longibrachiatum is an additional probable cause of positive galactomannan results. Although, that Trichoderma is a rare but emerging pathogen in immunocompromised patients, the above information could be a caution point in the clinical evaluation of diagnostic results...
October 11, 2018: Current Microbiology
Agnes Loo Yee Cheah, Allen C Cheng, Denis Spelman, Roger L Nation, David C M Kong, Emma S McBryde
BACKGROUND: Clinical studies and mathematical simulation suggest that active surveillance with contact isolation is associated with reduced vancomycin-resistant enterococci (VRE) prevalence compared to passive surveillance. Models using pre- and post-intervention data that account for the imperfect observation and serial dependence of VRE transmission events can better estimate the effectiveness of active surveillance and subsequent contact isolation; however, such analyses have not been performed...
October 11, 2018: BMC Infectious Diseases
The Lancet Haematology
No abstract text is available yet for this article.
October 2018: Lancet Haematology
Ben Shillitoe, Rob Hollingsworth, Mark Foster, Tomaz Garcez, David Guzman, J David Edgar, Matthew Buckland
Supply of immunoglobulin in the UK faces pressures due to increasing demand, cost and variable supply. This paper describes immunoglobulin replacement therapy (IGRT) in primary immunodeficiency (PID) and secondary immunodeficiency (SID) to assist in the ongoing planning of UK immunoglobulin provision. A retrospective analysis of the National Immunoglobulin Database and the UKPID registry was carried out. In total, 3,222 patients are registered as receiving IGRT for immunodeficiencies. Predominately antibody disorders made up the largest diagnostic category (61% of patients)...
October 2018: Clinical Medicine: Journal of the Royal College of Physicians of London
Aishatu Muhammad Nalado, Johnny N Mahlangu, Raquel Duarte, Graham Paget, Gbenga Olorunfemi, Barry F Jacobson, Saraladevi Naicker
INTRODUCTION: Iron deficiency anaemia (IDA) worsens the prognosis and outcomes of chronic kidney disease (CKD). However, while the haemoglobin level is unreliable for early detection of IDA, reticulocyte haemoglobin content (CHr) and hypochromic red cells (%HYPO) are early markers of IDA. METHODS: This was a cross sectional study of black adult participants (n = 258) with CKD and apparently healthy members of staff and patients' relatives (n = 141) at the Charlotte Maxeke Johannesburg Academic Hospital, South Africa, between 1 June 2016 and 31 December 2016...
2018: PloS One
Paola Giordano, Flavia Urbano, Giuseppe Lassandro, Francesco Paolo Bianchi, Alessandra Tolva, Paola Saracco, Giovanna Russo, Lucia Dora Notarangelo, Maria Gabelli, Simone Cesaro, Malgorzata Wasniewska, Maria Felicia Faienza
BACKGROUND: Immune thrombocytopenia (ITP) is an acquired immune-mediated disorder characterized by isolated thrombocytopenia. Pediatric ITP patients are prone to develop autoantibodies such as antithyroglobulin (TG) and antithyroperoxidase (TPO), even in the absence of clinical signs of autoimmune disease. The aim of this multicenter retrospective study was to evaluate (1) the prevalence of positivity of antithyroid antibodies (TPO and TG) in a large cohort of pediatric patients with chronic ITP; (2) the role of autoimmune thyroiditis as a prognostic factor for chronicity of ITP...
September 30, 2018: Pediatric Blood & Cancer
George Ramsay, Duncan T Ritchie, Craig MacKay, Craig Parnaby, Graeme Murray, Leslie Samuel
BACKGROUND: Outcomes in locally advanced rectal cancer are improved by neoadjuvant therapy followed by surgical resection. Some patients respond completely to preoperative treatment. Therefore, predicting the pathological response to preoperative therapy is of clinical importance. Accurate prediction would allow for tailored approaches to neoadjuvant therapy. METHODS: All patients undergoing resection of rectal adenocarcinoma after neoadjuvant therapy between 2006 and 2015 were included in this cohort study...
September 28, 2018: Digestive Surgery
Karen Neoh, Ross Gray, John Grant-Casey, Lise Estcourt, Catherine Malia, Jason W Boland, Michael I Bennett
BACKGROUND: Red blood cell transfusions are commonly used in palliative care to treat anaemia or symptoms caused by anaemia. In patients with advanced disease, there is little evidence of benefit to guide treatment decisions in the face of increased risk of harms. AIM: To determine national transfusion practice in hospices and compare this against National Institute for Health and Care Excellence and British Society of Haematology guidelines to develop recommendations to improve practice...
September 27, 2018: Palliative Medicine
Ole Weis Bjerrum, Daniel El Fassi, Gitte Madsen, Jesper Stentoft, Hanne Vestergaard, Dorthe Rønnov-Jessen, Per Trøllund Pedersen, Stanislaw Pulczynski, Ulrik Malthe Overgaard, Christen Lykkegaard Andersen
When the number of eosinophil granulocytes in blood increases, the cause is not always easy to disentangle. This review highlights the symptoms of rare clonal and common reactive diagnoses, how to approach the patient clinically, and how to implement the armamentarium of available tests in order to identify the correct diagnosis and offer the proper treatment. Two referral centres for eosinophilia have been established in Denmark to support this activity by a collaboration between all departments of haematology and the relevant specialities, meeting the manifestations of eosinophilia...
September 10, 2018: Ugeskrift for Laeger
Sam E Grigg, Patrick Date, Zoe Loh, Ortis Estacio, Douglas F Johnson, Eliza A Hawkes, Andrew Grigg
PURPOSE: There is a paucity of data regarding the utility of routine urine cultures in adults with febrile neutropenia (FN) without urinary symptoms receiving protocolised antibiotics. This is reflected by inconsistent recommendations in international and regional FN guidelines. We addressed this issue by retrospectively reviewing the impact of routine urine cultures on antibiotic management in haematology cancer inpatients at a tertiary hospital. METHODS: All haematology inpatients over a 5-year period (2011-2015) were retrospectively reviewed for episodes of FN (neutrophil count < 0...
September 27, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Farhat Butt, Martin McKibbin
BACKGROUND: Bone marrow transplantation retinopathy is a rare condition affecting the posterior pole. The purpose of this case report is to highlight the possible risk factors and clinical features. CASE PRESENTATION: A 19y old male with relapsed and refractory acute lymphoblastic leukaemia was admitted under haematology with pyrexia of unknown origin. At the time of his admission, he reported bilateral and sequential visual impairment for 2 days. On examination, there was bilateral profound retinopathy across the posterior poles...
September 14, 2018: BMC Ophthalmology
O E Ola-Davies, O I Azeez, A A Oyagbemi, M O Abatan
Indiscriminate use of organophosphate acaricides especially among livestock and dog owners in the control of ticks and other ectoparasites has taken a worrisome dimension. In the present study, we investigated, the effects of acute dermal exposure in the form of acaricides baths of coumaphos at different concentrations on the haematology, blood pressure and liver functions in local mongrel dogs. Twenty-four, male mongrel dogs of about 8 months of age with an average weight of 9.88 ± 0.4 kg were used for the study...
June 2018: International Journal of Veterinary Science and Medicine
Turke Shawaf, Jamal Hussen, Mohammed Al-Zoubi, Hassein Hamaash, Khalid Al-Busadah
The Shetland ponies, which originate from harshest environments in the world islands in the north of the Atlantic Ocean, are now most popular pony breed distributed in almost every corner of the world. Reference ranges of physiological, biochemical and haematological values, which are widely used in veterinary clinics, may differ according to season, age, sex, type of feeding, and environmental circumstances of the area. Reference ranges of haematological and biochemical values of Shetland ponies are rare. The present study was therefore undertaken to evaluate the impact of season, age and sex on some haematological and biochemical values and cortisol levels in healthy ponies in Saudi Arabia...
June 2018: International Journal of Veterinary Science and Medicine
Imani B Kapinga, Samwel M Limbu, Nazael A Madalla, Wahabu H Kimaro, Rashid A Tamatamah
Growing mixed-sex Nile tilapia, Oreochromis niloticus in earthen ponds to table size is a major challenge due to its early maturity and prolific breeding. This study determined the effects of two medicinal plants; Aspilia plant, Aspilia mossambicensis and Neem tree, Azadirachta indica on hatchlings production, growth performance, feed utilization, survival and haematology of O. niloticus . Experimental diets were prepared by adding 1.0, 2.0, 4.0 and 8.0 g of either A. mossambicensis or A. indica leaf powders into a kg of the control diet subsequently administered daily to twenty triplicates of O...
June 2018: International Journal of Veterinary Science and Medicine
Ahmed M Elkhalifa
OBJECTIVES: To study the effects of heavy cigarette smoking on coagulation (CGG) screening tests and platelet counts (PLTs) in a Sudanese male adults population. METHODS: A case control study was conducted at both Kosti and Gabalein towns, Sudan, during October 2016 to May 2017. A 100 adult cigarette smokers were selected and another 100 matched non-smokers were selected as healthy controls. Blood samples were collected in trisodium citrate anti-coagulant for prothrombin time (PT), partial thromboplastin time (PTT), and international normalized ratio (INR), analyzed using standard methods (co-agulometer machine) and Ethylenediaminetetraacetic acid for the platelet counts, using an automated haematology analyzer (Sysmex, Tokoyo, Japan)...
September 2018: Saudi Medical Journal
Rene Ning Teh, Irene Ule Ngole Sumbele, Derick Ndelle Meduke, Samuel Takang Ojong, Helen Kuokuo Kimbi
BACKGROUND: Malaria, anaemia and malnutrition are frequently co-existing diseases that cause significant morbidity and mortality particularly among children. This study measured the prevalence, intensity and evaluated risk factors for malaria parasitaemia, anaemia and malnutrition among children living at low versus high altitude settings in the Mount Cameroon area. METHODS: A cross-sectional community based survey involving 828 children aged 6 months to 14 years was conducted between July and November 2017...
September 24, 2018: Malaria Journal
Tisungane Mvalo, Brian Eley, Colleen Bamford, Christopher Stanley, Maganizo Chagomerana, Marc Hendricks, Ann Van Eyssen, Alan Davidson
OBJECTIVES: This study investigated the epidemiology of bloodstream infection (BSI) in oncology patients at Red Cross War Memorial Children's Hospital (RCWMCH), Cape Town with focus on the commonest causes, complications and antimicrobial susceptibilities in BSI. METHODS: A retrospective cross-sectional study was conducted at the haematology-oncology unit of RCWMCH. All positive blood cultures from RCWMCH oncology patients taken in 2012 to 2014 were retrieved to identify BSI cases...
September 19, 2018: International Journal of Infectious Diseases: IJID
Ebenezer Yaw Ganyo, Johnson N Boampong, Daniel K Masiga, Jandouwe Villinger, Paa Kobina Turkson
Background: Animal trypanosomosis is a major cause of economic loss in livestock production in Africa. A suggested control measure is to use breeds with traits of trypanotolerance. The study examines the effect of natural Trypanosoma vivax challenge on haematological parameters in two trypanotolerant cattle [N'Dama and West African Short Horn (WASH)] herds. Methods: T. vivax -specific primers were used to diagnose T. vivax infection in an N'Dama herd at Cape Coast in southern Ghana and a WASH herd at Chegbani in northern Ghana from May to July 2011 in a cross-sectional study...
2018: F1000Research
M E Wright, E L Croser, S Raidal, R M Baral, W Robinson, J Lievaart, K P Freeman
BACKGROUND: Clinical pathology results are typically interpreted by referring to population-based reference intervals. The use of individualised (subject-based) reference intervals is more appropriate for measurands with a high degree of variation between individuals. OBJECTIVES: To determine the biological variation of routinely analysed equine haematology and biochemistry measurands and calculate indices of individuality and reference change values which enable production of individualised reference intervals, in a group of healthy, privately owned horses...
September 8, 2018: Equine Veterinary Journal
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