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Yi-Chen Yeh, Hua-Lin Kao, Kang-Lung Lee, Mei-Han Wu, Hsiang-Ling Ho, Teh-Ying Chou
Lymphoepithelioma-like carcinoma (LELC) of the lung is a rare Epstein-Barr virus (EBV)-associated carcinoma. It is histologically characterized by a syncytial growth pattern with marked lymphocytic infiltration that is indistinguishable from the histology observed in undifferentiated nasopharyngeal carcinomas. However, it has been noted that LELC can display nonclassic morphology and lack significant lymphocytic infiltration. In this study, we conducted a comprehensive clinicopathologic analysis of 61 patients with pulmonary LELC and performed automatic quantification of the lymphocytic infiltrate using the IHC Profiler software...
October 16, 2018: American Journal of Surgical Pathology
Adam C Wilberger, Xiayuan Liang
Peripheral NK/T-cell lymphoma (PNKTCL) represents a group of uncommon diagnoses for children in Western countries, and studies have often necessitated multiple institutions to assemble enough cases. We retrospectively analyzed 11 cases of nonanaplastic PNKTCL in children over 19 years at our institution with comparison to several published large multi-institutional studies. Patients included 9 males and 2 females of white (5), Native American (3), and Hispanic (3) background with 6 cases of extranodal NK/T-cell lymphoma, nasal type (EN-NKTL, 54...
October 18, 2018: Pediatric and Developmental Pathology
Jian-Hua Han, Hai-Feng Wang, Fang-Hu Chen, Gang Chen
OBJECTIVE: To investigate the clinical effect of absorbable screw fixation by anterolateral approach (McFarland and Osborne approach) for the treatment of Pipkin type I and type II fractures. METHODS: From March 2008 to February 2016, 8 cases of femoral head fractures were treated by absorbable screw fixation through anterolateral approach (McFarland and Osborne approach) including 5 males and 3 females with an average age of 36 years old ranging 23 to 58 years old...
September 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
Douglas G Widman, Savanna Gornisiewicz, Sharon Shacham, Sharon Tamir
Infection of immunocompromised individuals with normally benign opportunistic viruses is a major health burden globally. Infections with viruses such as Epstein-Barr virus (EBV), human cytomegalovirus (HCMV), Kaposi's sarcoma virus (KSHV), adenoviruses (AdV), BK virus (BKPyV), John Cunningham virus (JCPyV), and human papillomavirus (HPV) are significant concerns for the immunocompromised, including when these viruses exist as a co-infection with human immunodeficiency virus (HIV). These viral infections are more complicated in patients with a weakened immune system, and often manifest as malignancies resulting in significant morbidity and mortality...
2018: PloS One
Jian-Jun Ding, Ya-Lian Chen, Shui-Hong Zhou, Kui Zhao
Natural killer/T-cell lymphoma (NKTL) is a rare subtype of non-Hodgkin's lymphoma that is associated with Epstein-Barr virus infection. The clinicopathological features of NKTL are unique among lymphomas. NKTL is an aggressive disease with a poor prognosis in the absence of effective treatment. Accurate diagnosis and staging are essential to ensure an appropriate treatment strategy and accurate prognosis of NKTL. 18 F-Fluorodexoyglucose-positron emission tomography/computed tomography (18 F-FDG PET/CT) is a valuable technique in the diagnosis, staging, and prognostic evaluation of various types of malignant tumors, including NKTL...
October 17, 2018: Journal of International Medical Research
Kate Hopper, Marlis L Rezende, Angela Borchers, Steven E Epstein
The efficacy of ventilation of dogs during cardiopulmonary resuscitation (CPR) with a tight fitting face mask or mouth-to-nose rescue breathing has not been evaluated. Twenty-four purpose bred research dogs: Dogs were randomized to be ventilated by cuffed orotracheal tube, tight fitting face mask, mouth-to-nose breathing or compressions only during CPR ( n = 6 in all groups). Orotracheal tube and face mask ventilation was performed on room air. Chest compressions were performed during the experimental procedure...
2018: Frontiers in Veterinary Science
Yasushi Matsuzaki, Satoko Minakawa, Chihiro Sagara, Noriko Takiyoshi, Hajime Nakano, Daisuke Sawamura
No abstract text is available yet for this article.
October 15, 2018: European Journal of Dermatology: EJD
David Dahan, Gali Epstein Shochet, Ester Fizitsky, Miriam Almagor, David Shitrit
BACKGROUND: Sepsis is a common cause of hospitalization, particularly in intensive care units (ICUs), and is a major cause of morbidity and mortality. Diagnosis is often difficult due to the absence of characteristic clinical signs (e.g., fever and leukocytosis); therefore, additional markers, in addition to C-reactive protein (CRP) and white blood cell (WBC) count, are needed. OBJECTIVES: To prospectively link resting energy expenditure (REE) with CRP, WBC count, and sequential organ failure assessment (SOFA) scores in ICU patients...
October 2018: Israel Medical Association Journal: IMAJ
Harini D de Silva, Rosemary A Ffrench, Maya Korem, Eva Orlowski, David J Curtis, Andrew Spencer, Sharon Avery, Sushrut Patil, Catherine Orla Morrissey
Objectives: Infections are a major cause of mortality after allogeneic haemopoietic stem cell transplantation (alloHSCT), and immune recovery is necessary for prevention. Novel transplant procedures have changed the epidemiology of infections but contemporary data on functional immune recovery are limited. In this pilot study, we aimed to measure immune recovery in the current era of alloHSCT. Methods: Twenty, 13, 11, 9 and 9 alloHSCT recipients had blood collected at baseline (time of conditioning) and 3-, 6-, 9-, and 12-months post-alloHSCT, respectively...
2018: Clinical & Translational Immunology
Rutika Mehta, Anand Shah, Khaldoun Almhanna
Gastric and esopahgeal cancers account for the six most common causes of cancer death worldwide. Locally advanced resectable cancers have a 5-year life expectancy of 30%. Despite use of chemotherapy, median overall survival for stage IV cancer rarely exceeds 1 year. A subset of gastric cancers such as microsatellite-instable tumor and Epstein-Barr virus-positive tumors have a rich immune infiltrate that makes them more responsive to immune-directed therapies. Tumors can evade T-cell-mediated "immune surveillance" by activating the programmed cell death receptor 1 (PD-1)/programmed death ligand 1 (PD-L1) pathway...
2018: OncoTargets and Therapy
Marco Venniro, Michelle Zhang, Daniele Caprioli, Jennifer K Hoots, Sam A Golden, Conor Heins, Marisela Morales, David H Epstein, Yavin Shaham
Addiction treatment has not been appreciably improved by neuroscientific research. One problem is that mechanistic studies using rodent models do not incorporate volitional social factors, which play a critical role in human addiction. Here, using rats, we introduce an operant model of choice between drugs and social interaction. Independent of sex, drug class, drug dose, training conditions, abstinence duration, social housing, or addiction score in Diagnostic & Statistical Manual IV-based and intermittent access models, operant social reward prevented drug self-administration...
October 15, 2018: Nature Neuroscience
Shuang Gao, Yingming Zhou, Xiaolong Jin, Zhongjing Lin, Yisheng Zhong, Xi Shen
A 50-year-old woman developed recurrent vitreous opacities in her left eye. The first diagnostic vitrectomy revealed no significant abnormality. OCT showed multiple high-density reflective nodules. The ratio of Interleukin 6 to 10 was over 1 in her aqueous humor, and Epstein-Barr virus was present. Conventional immunohistochemistry examination of vitrectomy specimens was diffusely positive for CD2, CD3, Ki67. Highly-metabolic nodules were found in her right breast on PET-CT scan. Immunohistochemistry of the breast biopsy was suggestive of NK/T cell lymphoma...
October 12, 2018: Survey of Ophthalmology
Ori Wand, Elad Guber, Alexander Guber, Gali Epstein Shochet, Lilach Israeli-Shani, David Shitrit
BACKGROUND: Tranexamic Acid (TA) is an antifibrinolytic drug currently used systemically to control bleeding. To date, there are no prospective studies of the effectiveness of inhaled TA for hemoptysis treatment. OBJECTIVE: To prospectively assess the effectiveness of TA inhalations (i.e. nebulized TA) for hemoptysis treatment. METHODS: We conducted a double-blind, randomized controlled trial of treatment with nebulize TA (500mg, three times daily) vs...
October 12, 2018: Chest
Andre Pinto, Marilyn Huang, Mehrdad Nadji
Objectives: Lymphoepithelioma-like carcinoma (LELC) of the uterine cervix is a rare tumor. The goal of this study was to evaluate a series of cases of cervical LELC and to investigate possible association with human papillomavirus (HPV) and/or Epstein-Barr virus (EBV). Methods: Immunohistochemistry for p63, p16, human leukocyte antigen-D related (HLA-DR), and B-cell lymphoma 2 (BCL-2); in situ hybridization (ISH) for EBV and HPV; and polymerase chain reaction (PCR) genotyping were performed...
October 15, 2018: American Journal of Clinical Pathology
Camille A Farfan, Jordan Epstein, Daniel B Turner
A key requirement for femtosecond spectroscopy measurements is to compress the laser pulse to its transform-limited duration. In particular, for few-cycle laser pulses, the compression process is time-consuming using conventional algorithms that converge statistically. Here we show that machine learning can accelerate the process of pulse compression: we have developed an adaptive neural-network algorithm to control a deformable-mirror-based pulse shaper that converges 100× faster than a standard evolutionary algorithm...
October 15, 2018: Optics Letters
Alejandro A Gru, Eli Williams, Jacqueline M Junkins-Hopkins
Iatrogenic lymphoproliferative disorders have been described in patients receiving immunosuppressive/immunomodulatory agents outside the transplantation setting. Novel biological agents such as TNF-α blockers and JAK-inhibitors have also proven to be effective in many disorders including rheumatoid arthritis, inflammatory bowel disease (ulcerative colitis and Crohn disease), psoriasis, and others. A significant dilemma exists in those lymphoproliferative disorders associated with immunosuppressants and rheumatologic conditions, that relies on whether the association of the process is with the medication or the underlying autoimmune condition...
October 12, 2018: American Journal of Surgical Pathology
Zhendong Zhu, Yunmei Zhang, Jiyun Ye, Xuechang Wang, Xuemei Fu, Yan Yin, Jin Wen, Xinran Wu, Zhonghua Xia
Interleukin (IL)-35 is a heterodimeric cytokine composed of the IL-12A subunit and the Epstein-Barr virus induced gene 3 (EBI3) subunit. Binding of IL-35 with IL-12 receptor subunit beta 2 (IL-12RB2) and IL-6 signal transducer (IL-6ST) occupies the binding sites of IL-6, IL-12, and IL-27 and prevents their signal transduction. IL-35 is also shown to promote the development of regulatory T cells (Tregs) and regulatory B cells (Bregs). In this study, we investigated B cell-mediated IL-35 production in patients with coronary artery disease (CAD)...
October 11, 2018: Human Immunology
Anupriya Dutta, Hajime Uno, David R Lorenz, Steven M Wolinsky, Dana Gabuzda
Immunological parameters that influence susceptibility to virus-associated cancers in HIV-seronegative individuals are unclear. We conducted a case-control cohort study of immunological parameters associated with development of incident virus-associated cancers among 532 HIV-seronegative men who have sex with men (MSM) enrolled in the Multicenter AIDS Cohort Study (MACS) with median (IQR) 21 (8-26) years of follow-up. Thirty-two incident virus-associated cancers (anal cancer, non-Hodgkin lymphoma, liver cancer, other cancers with etiologies linked to human papillomavirus, Epstein-Barr virus, hepatitis B virus, or human herpesvirus-8) were identified among 3,408 HIV-seronegative men in the MACS during 1984-2010...
October 12, 2018: Cancer Causes & Control: CCC
Jaret Daniels, Chase Kimmel, Simon McClung, Samm Epstein, Jonathan Bremer, Kristin Rossetti
The North American monarch butterfly ( Danaus plexippus ) population has declined significantly over the past two decades. Among the many other factors, loss of breeding habitat has been implicated as a potential leading driver. In response, wildlife agencies and conservation practitioners have made a strong push to restore and conserve milkweeds on both wild and managed landscapes including agricultural lands as well as transportation and utility rights-of-way. Roadsides in particular have been emphasized as a targeted landscape for monarch habitat restoration...
October 11, 2018: Insects
Nicholas A Smith, Paul C Baresel, Conner L Jackson, Sidney Ogolla, Eunice N Toko, Sara Heit, Erwan Piriou, Odada P Sumba, Jaap M Middeldorp, Kathryn L Colborn, Rosemary Rochford
Background: The EBV viral glycoprotein gp350 has been proposed as a candidate antigen for an EBV vaccine. However, the proposed formulations of these vaccines have not taken into account the presence of two unique EBV strains (EBV-1 and EBV-2) present in areas of high incidence of the EBV associated cancer, Burkitt's lymphoma. Methods: In this study, we analyze the kinetics of EBV-1 and EBV-2 infection in an asymptomatic infant cohort from Kisumu, Kenya. We also analyzed the kinetics of the antibody response against five EBV antigens, gp350 (IgG and IgA), VCA (IgG), EBNA-1 (IgG), EAd (IgG), and Zta (IgG)...
October 12, 2018: Journal of Infectious Diseases
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