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Rou-Jun Peng, Bo-Wei Han, Qing-Qing Cai, Xiao-Yu Zuo, Tao Xia, Jie-Rong Chen, Li-Na Feng, Jing Quan Lim, Shu-Wei Chen, Mu-Sheng Zeng, Yun-Miao Guo, Bo Li, Xiao-Jun Xia, Yi Xia, Yurike Laurensia, Burton Kuan Hui Chia, Hui-Qiang Huang, Ken He Young, Soon Thye Lim, Choon Kiat Ong, Yi-Xin Zeng, Jin-Xin Bei
Extranodal natural killer T-cell lymphoma (nasal type; NKTCL) is an aggressive malignancy strongly associated with Epstein-Barr virus (EBV) infection. However, the role of EBV in NKTCL development is unclear, largely due to the lack of information about EBV genome and transcriptome in NKTCL. Here, using high-throughput sequencing, we obtained whole genome (n = 27) and transcriptome datasets (n = 18) of EBV derived from NKTCL tumor biopsies. We assembled 27 EBV genomes and detected an average of 1,152 single nucleotide variants and 44...
December 13, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
Stephanie Pei Tung Yiu, Kwai Fung Hui, Chung King Choi, Richard Yi Tsun Kao, Chi Wang Ma, Dan Yang, Alan Kwok Shing Chiang
Pharmaceutical reactivation of lytic cycle of Epstein⁻Barr virus (EBV) represents a potential therapeutic strategy against EBV-associated epithelial malignancies, e.g., gastric carcinoma (GC) and nasopharyngeal carcinoma (NPC). A novel lytic-inducing compound, C7, which exhibits structural similarity to Di-2-Pyridyl Ketone 4, 4-Dimethyl-3-Thiosemicarbazone (Dp44mT), a known chelator of intracellular iron, is found to reactivate EBV lytic cycle in GC and NPC. This study aims to investigate the role of intracellular iron chelation by C7 and other iron chelators in lytic reactivation of EBV in GC and NPC...
December 11, 2018: Cancers
Yanbao Yu, Tamara Tsitrin, Harinder Singh, Sebastian N Doerfert, Maria V Sizova, Slava S Epstein, Rembert Pieper
Actinobaculum massiliense , a Gram-positive anaerobic coccoid rod colonizing the human urinary tract, belongs to the taxonomic class of Actinobacteria. We identified A. massiliense as a cohabitant of urethral catheter biofilms (CB). The CBs also harbored more common uropathogens, such as Proteus mirabilis and Aerococcus urinae , supporting the notion that A. massiliense is adapted to a life style in polymicrobial biofilms. We isolated a clinical strain from a blood agar colony and used 16S rRNA gene sequencing and shotgun proteomics to confirm its identity as A...
December 9, 2018: Proteomes
Mingliang Sui, Weibing Tang, Changjiang Wu
RATIONALE: The Epstein-Barr (EB) virus has rarely been reported as a cause of fulminant myocarditis. To our knowledge, the present case is the first report on myocardial calcification in EB viral myocarditis and rhabdomyolysis. PATIENT CONCERNS: A 17-year-old man was admitted to the department with fever, chest tightness, and tachypnea that had been present for 2 days. DIAGNOSES: The initial investigation showed elevated liver enzyme levels, creatine kinase levels, creatine kinase isoenzyme levels, and elevated serum myoglobin...
December 2018: Medicine (Baltimore)
Ghulam Rehman Mohyuddin, John Roller, Leyla Shune, Tara Lin, Ajoy Dias, Siddhartha Ganguly, Sunil Abhyankar, Joseph McGuirk, Anurag Singh
No abstract text is available yet for this article.
December 9, 2018: Hematology/oncology and Stem Cell Therapy
Susanne Delecluse, Ming-Han Tsai, Anatoliy Shumilov, Maja Bencun, Sebastian Arrow, Aisha Beshirova, Andréa Cottignies-Calamarte, Felix Lasitschka, Olcay Cem Bulut, Christian Münz, Martin Zeier, Uta Behrends, Henri-Jacques Delecluse
The Epstein-Barr virus (EBV) infects the oropharynx but surprisingly frequently induces B-cell proliferations in the gut of immunosuppressed individuals. We found that EBV infection in vitro induces the expression of the LPAM-1 integrin on tonsillar B cells and increases it on peripheral blood cells. Similarly, LPAM-1 was induced in the tonsils of patients undergoing primary infectious mononucleosis. EBV-induced LPAM-1 bound to the MAdCAM-1 addressin that allows B-cell homing to the gastrointestinal mucosa-associated lymphoid tissue (GALT)...
December 12, 2018: Journal of Virology
Wenmin Fu, Dinesh Verma, Ashlee Burton, Sankar Swaminathan
Epstein-Barr virus SM protein is an RNA-binding protein that has multiple post-transcriptional gene regulatory functions essential for EBV lytic replication. In this study, we identified an interaction between SM and DHX9, a DExH-box helicase family member, by mass spectrometry and co-immunoprecipitation. DHX9 participates in many cellular pathways involving RNA, including transcription, processing, transport and translation. DHX9 enhances virus production or infectivity of a wide variety of DNA and RNA viruses...
December 12, 2018: Journal of Virology
Molly K Candon, Colleen L Barry, Steven C Marcus, Andrew J Epstein, Alene Kennedy-Hendricks, Ming Xie, David S Mandell
BACKGROUND: The health care costs associated with treating autism spectrum disorder (ASD) in children can be substantial. State-level mandates that require insurers to cover ASD-specific services may lessen the financial burden families face by shifting health care spending to insurers. METHODS: We estimated the effects of ASD mandates on out-of-pocket spending, insurer spending, and the share of total spending paid out of pocket for ASD-specific services. We used administrative claims data from 2008 to 2012 from 3 commercial insurers, and took a difference-in-differences approach in which children who were subject to mandates were compared with children who were not...
December 12, 2018: Pediatrics
Clémentine Sarkozy, Christiane Copie-Bergmand, Diane Damotte, Susana Ben-Neriah, Barbara Burroni, Jérome Cornillon, Richard Lemal, Camille Golfier, Bettina Fabiani, Catherine Chassagne-Clément, Marie Parrens, Charles Herbaux, Luc Xerri, Celine Bossard, Camille Laurent, Morgane Cheminant, Guillaume Cartron, Jose Cabecadas, Thierry Molina, Gilles Salles, Christian Steidl, Hervé Ghesquières, Anja Mottok, Alexandra Traverse-Glehen
Gray-zone lymphoma (GZL) with features intermediate between classic Hodgkin lymphoma (cHL) and large B-cell lymphoma (LBCL) was introduced as a provisional entity into the World Health Organization classification in 2008. However, as diagnostic criteria are imprecise, reliable identification of GZL cases remains challenging. Here, we describe the histopathologic features of 139 GZL cases from a retrospective Lymphoma Study Association (LYSA) study with the goal to improve classification accuracy. Inclusion criteria were based on literature review and an expert consensus opinion of the LYSA hematopathologist panel...
December 11, 2018: American Journal of Surgical Pathology
Shao-Bing Dai, Ting Shen, Ting-Ting Zheng, Jia-Li Pu, Xin-Zhong Chen
Differentiation of human fibroblasts into functional neurons depends on the introduction of viral-mediated transcription factors, which present risks of viral gene integration and tumorigenicity. In recent years, although some studies have been successful in directly inducing neurons through sustained expression of small molecule compounds, they have only been shown to be effective on mouse-derived cells. Thus, herein we delivered vectors containing Epstein-Barr virus-derived oriP/Epstein-Barr nuclear antigen 1 encoding the neuronal transcription factor, Ascl1, the neuron-specific microRNA, miR124, and a small hairpin directed against p53, into human fibroblasts...
March 2019: Neural Regeneration Research
Yi Guan, Dejan Jakimovski, Murali Ramanathan, Bianca Weinstock-Guttman, Robert Zivadinov
Multiple sclerosis (MS) is a disease of the central nervous system characterized by inflammation, demyelination, and neuronal damage. Environmental and genetic factors are associated with the risk of developing MS, but the exact cause still remains unidentified. Epstein-Barr virus (EBV), vitamin D, and smoking are among the most well-established environmental risk factors in MS. Infectious mononucleosis, which is caused by delayed primary EBV infection, increases the risk of developing MS. EBV may also contribute to MS pathogenesis indirectly by activating silent human endogenous retrovirus-W...
March 2019: Neural Regeneration Research
Hiroyuki Kishi, Tatsuhiko Ozawa, Hiroshi Hamana, Eiji Kobayashi, Atsushi Muraguchi
Antigen-specific monoclonal antibodies are useful tools to detect very small amounts of antigenic materials and are applicable for antibody therapeutics. To produce mouse monoclonal antibodies, a hybridoma between B lymphocytes and myeloma cells is used to produce antigen-specific monoclonal antibodies. However, a good hybridoma system is not available to obtain human monoclonal antibodies. To produce antigen-specific human monoclonal antibodies, transformation of B lymphocytes with Epstein-Barr viruses or a phage-display system is used...
2019: Methods in Molecular Biology
Anjali V Desai, Virginia M Klimek, Kimberly Chow, Andrew S Epstein, Camila Bernal, Kelly Anderson, Molly Okpako, Robin Rawlins-Duell, Dana Kramer, Danielle Romano, Jessica I Goldberg, Judith E Nelson
BACKGROUND: Prior work to integrate early palliative care in oncology has focused on patients with advanced cancer and primarily on palliative care consultation. We developed this outpatient clinic initiative for newly diagnosed patients at any stage, emphasizing primary (nonspecialist) palliative care by oncology teams, with enhanced access to palliative care specialists. METHODS: We piloted the project in two medical oncology specialty clinics (for patients with myelodysplastic syndrome and GI cancer, respectively) to establish feasibility...
December 2018: Journal of Oncology Practice
Kwai Fung Hui, Tsz Fung Chan, Wanling Yang, Jiangshan Jane Shen, Ki Pui Lam, Hin Kwok, Pak C Sham, Sai Wah Tsao, Dora L Kwong, Maria Li Lung, Alan Kwok Shing Chiang
Whether certain variants of Epstein-Barr virus (EBV) are linked to the pathogenesis of nasopharyngeal carcinoma (NPC), which shows a marked geographic restriction, remains an unresolved issue. We performed a case-control study comparing genomic sequences of EBV isolated from saliva samples of 142 population carriers with those from primary tumour biopsies derived from 62 patients with NPC of Hong Kong. Cluster analysis discovered five EBV subgroups 1A-C and 2A-B amongst the population carriers in contrast to the predominance of 1A and -B in the majority of NPC...
December 10, 2018: International Journal of Cancer. Journal International du Cancer
Ryu Yanagisawa, Yozo Nakazawa, Kazuyuki Matsuda, Takahiro Yasumi, Hirokazu Kanegane, Shouichi Ohga, Akira Morimoto, Yoshiko Hashii, Masue Imaizumi, Yasuhiro Okamoto, Akiko M Saito, Keizo Horibe, Eiichi Ishii
Recent advances in intensive chemo- and immunotherapy have contributed to the outcome of hemophagocytic lymphohistiocytosis (HLH); however, the prognosis of HLH in children differs by HLH subtype. In Japan, secondary HLH, particularly Epstein-Barr virus-associated HLH (EBV-HLH), is the most common HLH subtype. The prognosis of HLH has improved in recent years. We here conducted a prospective study of 73 patients who were treated with HLH-2004 protocol in Japan. EBV-HLH, familial HLH (FHL), and HLH of unknown etiology were seen in 41, 9, and 23 patients, respectively...
December 7, 2018: International Journal of Hematology
Tiffany M Jones, Marina Epstein, Karl G Hill, Jennifer A Bailey, J David Hawkins
The current study examines the continuity in comorbidity between substance use and internalizing mental health problems from adolescence to adulthood and investigates the general and specific predictors of comorbidity across development. Participants were drawn from the Seattle Social Development Project (N = 808), a gender-balanced, ethnically diverse longitudinal panel. Structural equation modeling was used to examine risk factors for comorbid substance use and internalizing problems in family and peer social environments; substance use- and mental health-specific social environments (family tobacco, alcohol, and marijuana use; family history of depression); and individual risk factors (behavioral disinhibition)...
December 7, 2018: Prevention Science: the Official Journal of the Society for Prevention Research
Shotaro Masuoka, Natsuko Kusunoki, Ryo Takamatsu, Hiroshi Takahashi, Kazuaki Tsuchiya, Shinichi Kawai, Toshihiro Nanki
OBJECTIVE: The objective of the present study was to investigate Epstein-Barr virus (EBV) infection as an environmental factor for the development of rheumatoid arthritis (RA). METHODS: Synovial tissues were collected during surgery from 128 RA and 98 osteoarthritis (OA) patients. DNA was extracted from synovial tissues. The EBV gene was assessed by nested PCR for the amplification of EBV nuclear antigen-1 (EBNA-1). The nucleotide sequence of the PCR product was elucidated...
2018: PloS One
Feng Gu, Chong Wang, Fang Wei, Yuyan Wang, Qing Zhu, Ling Ding, Wenjia Xu, Caixia Zhu, Cankun Cai, Zhikang Qian, Zhenghong Yuan, Erle Robertson, Qiliang Cai
Aberrations in STAT6-mediated signaling are linked to the development of multiple cancer types. Increasing evidence has shown that activation of human oncogenic herpesvirus lytic replication is crucial for viral tumorigenesis. However, the role of STAT6 in herpesvirus lytic replication remains elusive. Here, by using Kaposi's sarcoma-associated herpesvirus (KSHV) as a model, we revealed that RTA, the master regulator of lytic replication, interacts with STAT6 and promotes lysine 48 (K48) and K63-linked ubiquitylation of STAT6 for degradation via the proteasome and lysosome systems...
December 2018: PLoS Pathogens
Gordana Halec, Tim Waterboer, Nicole Brenner, Julia Butt, David W Hardy, Gypsyamber D'Souza, Steven Wolinsky, Bernard J Macatangay, Michael Pawlita, Roger Detels, Otoniel Martínez-Maza, Shehnaz K Hussain
BACKGROUND: HIV infection is associated with increased susceptibility to common pathogens which may trigger chronic antigenic stimulation and hyperactivation of B-cells, events known to precede the development of AIDS-associated non-Hodgkin lymphoma (AIDS-NHL). METHODS: To explore whether cumulative exposure to infectious agents contributes to AIDS-NHL risk, we tested sera from 199 AIDS-NHL patients (pre-NHL, average lead-time 3.9 years) and 199 matched HIV-infected controls from the Multicenter AIDS Cohort Study (MACS), for anti-IgG responses to 18 pathogens using multiplex serology...
November 20, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Mónica García-Peris, M Isabel Jiménez Candel, Yolanda Mañes Jiménez, Macarena Pariente Martí, Damiana González Granda, Fernando Calvo Rigual
INTRODUCTION: The aim of this study is to assess epidemiological, clinical and laboratory characteristics of primary infection by Epstein-Barr virus (EBV) in children without previous diagnosis of any immune disease and its relationship with clinical presentation. PATIENTS AND METHODS: A retrospective study was conducted on all children from 0 to 15 years with IgM against viral capsid of EBV positive or indeterminate during a 22 month period. Epidemiological, clinical and laboratory data were analysed and compared between typical (mononucleosis syndrome) and non-typical clinical symptoms...
October 24, 2018: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
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