keyword
MENU ▼
Read by QxMD icon Read
search

Androstenedione

keyword
https://www.readbyqxmd.com/read/27905124/assessment-of-early-atherosclerosis-and-left-ventricular-dysfunction-in-children-with-21-hydroxylase-deficiency
#1
Rahmi Özdemir, Hüseyin Anil Korkmaz, Mehmet Küçük, Cem Karadeniz, Timur Meşe, Behzat Özkan
AIM: We analysed 25 children with 21-hydroxylase deficiency who received glucocorticoid and/or mineralocorticoid treatment for at least 12 months to determine the effects of the disease and its treatment on vascular structures and ventricular function. METHODS: Twenty-five patients with 21-hydroxylase-deficient congenital adrenal hyperplasia (CAH) and 25 control subjects were enrolled into this observational, cross-sectional study. The patients were investigated in terms of fasting blood glucose and insulin; fasting serum lipid profile; serum 17-hydroxyprogesterone; dehydroepiandrosterone sulphate; androstenedione; and adrenocorticotropic hormone...
November 7, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27901631/11-oxygenated-c19-steroids-are-the-predominant-androgens-in-polycystic-ovary-syndrome
#2
Michael W O'Reilly, Punith Kempegowda, Carl Jenkinson, Angela E Taylor, Jonathan L Quanson, Karl-Heinz Storbeck, Wiebke Arlt
CONTEXT: Androgen excess is a defining feature of polycystic ovary syndrome (PCOS) but the exact origin of hyperandrogenemia remains a matter of debate. Recent studies have highlighted the importance of the 11-oxygenated C19 steroid pathway to androgen metabolism in humans. In this study, we analyzed the contribution of 11-oxygenated androgens to the androgen excess phenotype in women with PCOS. METHODS: 114 women with PCOS and 49 healthy controls underwent measurement of serum androgens by liquid chromatography-tandem mass spectrometry...
November 30, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27871978/differences-in-testosterone-and-its-precursors-by-sex-of-the-offspring-in-meconium
#3
Alexander J Frey, Bo Y Park, Emily R Schriver, Daniel R Feldman, Samuel Parry, Lisa A Croen, Daniele M Fallin, Irva Hertz-Picciotto, Craig J Newschaffer, Nathaniel W Snyder
Prenatal metabolism exerts profound effects on development. The first stool of the newborn, meconium, provides a window into the prenatal metabolic environment. The objective of this study was to examine the feasibility of meconium as a novel matrix to quantify prenatal steroid levels. We quantified parameters of analytical interest regarding the use of meconium, including sample stability. We hypothesized that meconium steroid content would differ by sex, prompting analysis of meconium to test effects of prenatal steroid metabolism...
November 18, 2016: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27845856/modified-release-and-conventional-glucocorticoids-and-diurnal-androgen-excretion-in-congenital-adrenal-hyperplasia
#4
Christopher M Jones, Ashwini Mallappa, Nicole Reisch, Nikolaos Nikolaou, Nils Krone, Beverly A Hughes, Donna M O'Neil, Martin J Whitaker, Jeremy W Tomlinson, Karl-Heinz Storbeck, Deborah P Merke, Richard J Ross, Wiebke Arlt
CONTEXT: The classic androgen synthesis pathway proceeds via DHEA, androstenedione and testosterone to 5α-dihydrotestosterone (DHT). However, DHT synthesis can also be achieved by an alternative pathway originating from 17α-hydroxyprogesterone (17OHP), which accumulates in congenital adrenal hyperplasia (CAH). Similarly, recent work has highlighted androstenedione-derived 11-oxygenated 19-carbon steroids as active androgens and, in CAH, androstenedione is generated directly from 17OHP...
November 15, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27842549/acth-induced-stress-in-weaned-sows-impairs-lh-receptor-expression-and-steroidogenesis-capacity-in-the-ovary
#5
H S Zhu, Z Qian, H L Liu, E D Bao
BACKGROUND: Stress has been proved to impair the porcine reproduction soundly. Endocrine disruption, which is closely related to the persistent follicles, is possibly one of the results of stress, although the mechanism is unclear. Since the expression of luteinizing hormone receptor (LHR) in ovarian follicular wall and concentrations of steroid hormone in follicular fluid are related to the development of persistent follicles, this study is designed to evaluate the effect of administered adrenocorticotrophic hormone (ACTH) to weaned pigs on their ovarian steroidogenesis capacity and LHR expression...
November 14, 2016: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/27835057/effects-of-4-nonylphenol-on-the-steroidogenesis-of-human-adrenocarcinoma-cell-line-nci-h295r
#6
Jana Bistakova, Zsolt Forgacs, Zsuzsa Bartos, Maria Racz Szivosne, Tomas Jambor, Zuzana Knazicka, Eva Tvrda, Lubica Libova, Zofia Goc, Peter Massanyi, Norbert Lukac
In this study, the human H295R adrenocarcinoma cell line was exposed to different concentrations (0.04, 0.2, 1.0, 2.5 or 5 µg/mL) of nonylphenol (NP) to investigate its impact on the inhibition or induction of the steroid hormones production during 48 h of in vitro culture. The hormone production was measured using ELISA kits. Results of this in vitro study suggest various effect of nonylphenol in relatively low concentrations on the selected steroid hormones production by the human H295R adrenocarcinoma cell line...
November 11, 2016: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/27833751/leydig-cell-tumor-of-the-testis-with-azoospermia-and-elevated-delta4-androstenedione-case-report
#7
J Prasivoravong, A-L Barbotin, A Derveaux, C Leroy, X Leroy, P Puech, V Mitchell, F Marcelli, J-M Rigot
BACKGROUND: Secreting interstitial cell (Leydig cell) tumors are rare. In adults, the clinical picture and steroid levels are variable. CASE PRESENTATION: This paper presents a case of left testicular tumor, showing azoospermia with normal serum level of total testosterone, collapsed FSH and LH, and high delta4 androstenedione. Histopathological investigation revealed a Leydig cell tumor. TESE allowed spermatozoa extraction and freezing. Testicular histology found hypospermatogenesis and germ-cell aplasia with interstitial fibrosis...
2016: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/27797446/cross-sectional-association-of-endogenous-steroid-hormone-sex-hormone-binding-globulin-and-precursor-steroid-levels-with-hemostatic-factor-levels-in-postmenopausal-women
#8
Laura B Harrington, Brett T Marck, Kerri L Wiggins, Barbara McKnight, Susan R Heckbert, Nancy F Woods, Andrea Z LaCroix, Marc Blondon, Bruce M Psaty, Frits R Rosendaal, Alvin M Matsumoto, Nicholas L Smith
BACKGROUND: Oral use of exogenous estrogen/progestin alters hemostatic factor levels. The influence of endogenous hormones on these levels is incompletely characterized. OBJECTIVES: Our study aimed to test whether, among postmenopausal women, high levels of estradiol (E2), estrone (E1), testosterone (T), dehydroepiandrosterone-sulfate (DHEAS), DHEA, and androstenedione, and low levels of sex hormone-binding globulin (SHBG), are positively associated with measures of thrombin generation (TG), normalized activated protein C sensitivity ratio (nAPCsr), and factor VII activity (FVIIc), and negatively associated with antithrombin activity (ATc) and total protein S antigen (PSAg)...
October 31, 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/27790795/development-and-application-of-an-uhplc-ms-ms-method-for-the-simultaneous-determination-of-17-steroidal-hormones-in-equine-serum
#9
Michele Genangeli, Giovanni Caprioli, Manuela Cortese, Fulvio Laus, Mara Matteucci, Riccardo Petrelli, Massimo Ricciutelli, Gianni Sagratini, Stefano Sartori, Sauro Vittori
A new, fast and simple analytical method that is able to identify and quantify simultaneously 17 steroid hormones and metabolites (Pregnenolone, 17-OH-Pregnenolone, Progesterone, 17-OH Progesterone, Androsterone, Androstenedione, DHEA, DHEAS, Testosterone, Cortisol, Corticosterone, Aldosterone, 11-Deoxycortisol, 11-Deoxycorticosterone, Dihydrotestosterone, Estrone, Estradiol) has been developed in equine serum using the UHPLC-MS/MS technique. 400 μL of sample were deproteinized with 1000 µl of acetonitrile, evaporated, restored with 50 µl of a solution of 25% methanol and injected in UHPLC-MS/MS triple quadrupole...
October 27, 2016: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/27771738/serum-dehydroepiandrosterone-levels-are-associated-with-lower-risk-of-type-2-diabetes-the-rotterdam-study
#10
Adela Brahimaj, Taulant Muka, Maryam Kavousi, Joop S E Laven, Abbas Dehghan, Oscar H Franco
AIMS/HYPOTHESIS: Previous literature documents controversial results for the impact of dehydroepiandrosterone (DHEA) in glucose metabolism. We aimed to assess the associations between serum levels of DHEA and its main derivatives DHEA sulphate (DHEAS) and androstenedione, as well as the ratio of DHEAS to DHEA, and risk of type 2 diabetes. METHODS: We used data on serum levels of DHEA, DHEAS and androstenedione from 5189 middle-aged and elderly men and women from the prospective population-based Rotterdam Study...
October 22, 2016: Diabetologia
https://www.readbyqxmd.com/read/27758889/trpa1-mediates-aromatase-inhibitor-evoked-pain-by-the-aromatase-substrate-androstenedione
#11
Francesco De Logu, Raquel Tonello, Serena Materazzi, Romina Nassini, Camilla Fusi, Elisabetta Coppi, Simone Li Puma, Ilaria M Marone, Laura R Sadofsky, Alyn H Morice, Tommaso Susini, Alessandro Terreni, Gloriano Moneti, Mariarosaria Di Tommaso, Pierangelo Geppetti, Silvia Benemei
Aromatase inhibitors (AI) induce painful musculoskeletal symptoms (AIMSS), which are dependent upon the pain transducing receptor TRPA1. However, as the AI concentrations required to engage TRPA1 in mice are higher than those found in the plasma of patients, we hypothesized that additional factors may cooperate to induce AIMSS. Here we report that the aromatase substrate androstenedione, unique among several steroid hormones, targeted TRPA1 in peptidergic primary sensory neurons in rodent and human cells expressing the native or recombinant channel...
December 1, 2016: Cancer Research
https://www.readbyqxmd.com/read/27752129/exceptional-endocrine-profiles-characterise-the-meerkat-sex-status-and-reproductive-patterns
#12
Charli S Davies, Kendra N Smyth, Lydia K Greene, Debbie A Walsh, Jessica Mitchell, Tim Clutton-Brock, Christine M Drea
In vertebrates, reproductive endocrine concentrations are strongly differentiated by sex, with androgen biases typifying males and estrogen biases typifying females. These sex differences can be reduced in female-dominant species; however, even the most masculinised of females have less testosterone (T) than do conspecific males. To test if aggressively dominant, female meerkats (Suricata suricatta) may be hormonally masculinised, we measured serum androstenedione (A4), T and estradiol (E2) in both sexes and social classes, during both 'baseline' and reproductive events...
October 18, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27743906/validation-of-highly-sensitive-simultaneous-targeted-and-untargeted-analysis-of-keto-steroids-by-girard-p-derivatization-and-stable-isotope-dilution-liquid-chromatography-high-resolution-mass-spectrometry
#13
Alexander J Frey, Qingqing Wang, Christine Busch, Daniel Feldman, Lisa Bottalico, Clementina A Mesaros, Ian A Blair, Anil Vachani, Nathaniel W Snyder
A multiplexed quantitative method for the analysis of three major unconjugated steroids in human serum by stable isotope dilution liquid chromatography-high resolution mass spectrometry (LC-HRMS) was developed and validated on a Q Exactive Plus hybrid quadrupole/Orbitrap mass spectrometer. This quantification utilized isotope dilution and Girard P derivatization on the keto-groups of testosterone (T), androstenedione (AD) and dehydroepiandrosterone (DHEA) to improve ionization efficiency using electrospray ionization...
December 2016: Steroids
https://www.readbyqxmd.com/read/27732769/longitudinal-evaluation-of-the-isotope-ratio-mass-spectrometric-data-towards-the-isotopic-module-of-the-athlete-biological-passport
#14
Daniel Jardines, Francesco Botrè, Cristiana Colamonici, Davide Curcio, Gemma Procida, Xavier de la Torre
The detection of the abuse of pseudo-endogenous steroids (testosterone and/or its precursors) is currently based on the application of the steroid module of the World Anti-Doping Agency (WADA) Athletes' Biological Passport (ABP), implemented through ADAMS. Diagnostic metabolites are monitored for every athlete and statistically evaluated with a predictive Bayesian approach. In the case of suspicious samples, the data of the ABP are confirmed and the isotope ratio mass spectrometry (IRMS) test is activated. We have previously demonstrated that IRMS enables confirmation of the non-endogenous origin of pseudo-endogenous steroids in otherwise non-suspicious samples, after a longitudinal evaluation of the ABP, even after the inclusion of additional long-term diagnostic hydroxylated metabolites, and that the delta values of the parameters obtained during the IRMS confirmation process presented much less variability compared to the parameters of the ABP...
October 12, 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/27723553/the-evaluation-of-endothelial-function-and-structure-in-hirsute-patients-in-reproductive-age
#15
Kemal Atasayan, Tevfik Yoldemir, Sedef Ramoglu, Dilek Gogas Yavuz
OBJECTIVE: To evaluate the endothelial function and structure in patients with hirsutism in reproductive age. STUDY DESIGN: The study was conducted on 69 consecutive women admitted with complaints of hirsutism and 63 voluntary healthy women, as controls. A total of 132 subjects who applied to the Gynecology and Infertility Outpatient Clinics were included. Participants with modified Ferriman Gallway (mFG) score over 8 were considered to be hirsute. The demographic, metabolic, hormonal characteristics, risk factors of cardiovascular disease, CIMT (carotis intima media thickness) and FMD (flow-mediated dilatation) were compared between hirsute women and those in the control group...
October 3, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27698208/regulation-of-steroidogenesis-in-fetal-bovine-ovaries-differential-effects-of-lh-and-fsh
#16
Jeremy J Allen, Susan L Herrick, Joanne E Fortune
In cattle, primordial follicles form before birth. Fetal ovarian capacity to produce progesterone and estradiol is high before follicle formation begins and decreases around the time follicles first appear (around 90 days of gestation). However, mechanisms that regulate steroid production during this time remain unclear. We hypothesized that LH stimulates progesterone and androgen production and that FSH stimulates aromatization of androgens to estradiol. To test this, we cultured pieces from fetal bovine ovaries for 10 days without or with exogenous hormones and then measured the accumulation of steroids in the culture medium by RIA...
October 3, 2016: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/27692975/exposure-of-juvenile-turbot-scophthalmus-maximus-to-silver-nanoparticles-and-17%C3%AE-ethinylestradiol-mixtures-implications-for-contaminant-uptake-and-plasma-steroid-hormone-levels
#17
Julia Farkas, Iurgi Salaberria, Bjarne Styrishave, Radka Staňková, Tomasz M Ciesielski, Anders J Olsen, Wilfried Posch, Trond P Flaten, Åse Krøkje, Willi Salvenmoser, Bjørn M Jenssen
Combined exposure to engineered nanoparticles (ENPs) and anthropogenic contaminants can lead to changes in bioavailability, uptake and thus effects of both groups of contaminants. In this study we investigated effects of single and combined exposures of silver (Ag) nanoparticles (AgNPs) and the synthetic hormone 17α-ethinylestradiol (EE2) on tissue uptake of both contaminants in juvenile turbot (Scophthalmus maximus). Silver uptake and tissue distribution (gills, liver, kidney, stomach, muscle and bile) were analyzed following a 14-day, 2-h daily pulsed exposure to AgNPs (2 μg L(-1) and 200 μg L(-1)), Ag(+) (50 μg L(-1)), EE2 (50 ng L(-1)) and AgNP + EE2 (2 or 200 μg L(-1)+50 ng L(-1))...
January 2017: Environmental Pollution
https://www.readbyqxmd.com/read/27692342/per-and-polyfluoroalkyl-substances-pfass-new-endocrine-disruptors-in-polar-bears-ursus-maritimus
#18
Kathrine Eggers Pedersen, Robert J Letcher, Christian Sonne, Rune Dietz, Bjarne Styrishave
Per- and polyfluoroalkyl substances (PFASs) are emerging in the Arctic and accumulate in brain tissues of East Greenland (EG) polar bears. In vitro studies have shown that PFASs might possess endocrine disrupting abilities and therefore the present study was conducted to investigate potential PFAS induced alterations in brain steroid concentrations. The concentrations of eleven steroid hormones were determined in eight brain regions from ten EG polar bears. Pregnenolone (PRE), the dominant progestagen, was found in mean concentrations of 5-47ng/g (ww) depending on brain region...
September 27, 2016: Environment International
https://www.readbyqxmd.com/read/27690684/novel-adipokines-wisp1-and-betatrophin-in-pcos-relationship-to-amh-levels-atherogenic-and-metabolic-profile
#19
Gulcin Sahin Ersoy, Tugba Altun Ensari, Dogan Vatansever, Volkan Emirdar, Ozge Cevik
OBJECTIVE: To determine the levels of WISP1 and betatrophin in normal weight and obese women with polycystic ovary syndrome (PCOS) and to assess their relationship with anti-Müllerian hormone (AMH) levels, atherogenic profile and metabolic parameters Methods: In this prospective cross-sectional study, the study group was composed of 49 normal weighed and 34 obese women with PCOS diagnosed based on the Rotterdam criteria; 36 normal weight and 26 obese age matched non-hyperandrogenemic women with regular menstrual cycle...
September 30, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27688786/differential-effects-of-hydrocortisone-prednisone-and-dexamethasone-on-hormonal-and-pharmacokinetic-profiles-a-pilot-study-in-children-with-congenital-adrenal-hyperplasia
#20
Todd D Nebesio, Jamie L Renbarger, Zeina M Nabhan, Sydney E Ross, James E Slaven, Lang Li, Emily C Walvoord, Erica A Eugster
BACKGROUND: Little is known about the comparative effects of different glucocorticoids on the adrenal and growth hormone (GH) axes in children with congenital adrenal hyperplasia (CAH). We sought to compare the effects of hydrocortisone (HC), prednisone (PDN), and dexamethasone (DEX) in children with classic CAH and to investigate a potential role of pharmacogenetics. METHODS: Subjects were randomly assigned to three sequential 6-week courses of HC, PDN, and DEX, each followed by evaluation of adrenal hormones, IGF-1, GH, and body mass index (BMI)...
2016: International Journal of Pediatric Endocrinology
keyword
keyword
16940
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"