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Ben D Giudice, Thomas M Young, Jacob P Bibb
Municipal biosolids are commonly applied to agricultural lands as fertilizer, but this also poses potential risks to groundwater and surface water quality from constituents that may be mobilized during storm events. In the present study, an existing model, Groundwater Loading Effects of Agricultural Management Systems (GLEAMS), is modified to predict the fate and transport of organic contaminants from land-applied biosolids, primarily via addition of a labile biosolids organic carbon phase distinct from soil organic carbon...
January 11, 2019: Journal of Environmental Management
Terhi T Piltonen, Paolo Giacobini, Åsa Edvinsson, Steinar Hustad, Susanne Lager, Laure Morin-Papunen, Juha S Tapanainen, Inger Sundström-Poromaa, Riikka K Arffman
OBJECTIVE: To investigate plasma antimüllerian hormone (AMH) concentration and its relation to steroid hormone levels in pregnant women with polycystic ovary syndrome (PCOS) and controls at term. DESIGN: Case-control study. SETTING: University-affiliated hospital. PATIENT(S): A total of 74 pregnant women at term: 25 women with PCOS (aged 31.6 ± 3.9 years [mean ± standard deviation], body mass index 24.0 ± 3.9 kg/m2, mean gestational length 279 ± 9 days) and 49 controls (aged 31...
January 7, 2019: Fertility and Sterility
Taylor L Barnes, Kristin A Beede, Elena M Merrick, Caitlin N Cadaret, Andrea S Cupp, Dustin T Yates
No abstract text is available yet for this article.
September 2018: Translational animal science
Rihwa Choi, Hyung Doo Park, Hyeon Ju Oh, Kyounghoon Lee, Junghan Song, Soo Youn Lee
BACKGROUND: Screening for congenital adrenal hyperplasia (CAH) using immunoassays for 17α-hydroxyprogesterone generates many false-positive results. We developed and validated a liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay for simultaneous quantification of nine steroid hormones in dried blood spot (DBS) samples, and established reference intervals for these hormones. METHODS: We examined our method for linearity, precision, accuracy, extraction recovery, and matrix effects and determined the reference intervals of cortisol, 17α-hydroxyproges-terone, 11-deoxycortisol, 21-deoxycortisol, androstenedione, corticosterone, 11-deoxycorticosterone, testosterone, and progesterone in 1,146 DBS samples (from 272 preterm and 874 full-term neonates)...
May 2019: Annals of Laboratory Medicine
Fengsong Zhang, Qibiao Yu, Linsheng Yang
Natural steroid hormones in the aquatic environment have attracted increasing attention because of their strong endocrine disrupting potency. Seven steroid hormones (estrone, 17α-estradiol, 17β-estradiol, estriol, testosterone, androstenedione, and progesterone) were analyzed from surface water and sediment sampled from Chaohu Lake, its upstream rivers (the Hangbu River, Nanfei River, Shiwuli River, and Pai River), drainage from the adjacent farmland, and treated and untreated municipal sewage. Concentrations of the seven target steroid hormones ranged from below the detection limit (ND) to 69...
January 7, 2019: Environmental Science and Pollution Research International
F Z Stanczyk, S Chaikittisilpa, I Sriprasert, A Rafatnia, M Nadadur, D R Mishell
OBJECTIVE: This study aimed to determine the effect of oophorectomy on baseline serum levels of androgens and estrogens in premenopausal and postmenopausal women. METHODS: Fourteen premenopausal and 10 postmenopausal women underwent total hysterectomy and bilateral oophorectomy for benign disease of the uterus. Serum levels of dehydroepiandrosterone sulfate (DHEAS), androstenedione (A), testosterone (T), dihydrotestosterone (DHT), 5α-androstane-3α,17β-diol-17β-glucuronide (3α-diol G), estrone (E1 ), estradiol (E2 ), and sex hormone-binding globulin (SHBG) were measured by highly specific immunoassays prior to surgery and 2 weeks afterward...
January 7, 2019: Climacteric: the Journal of the International Menopause Society
Jan Idkowiak, Yasir S Elhassan, Pascoe Mannion, Karen Smith, Rachel Webster, Vrinda Saraff, Timothy G Barrett, Nicholas G Shaw, Nils Krone, Renuka P Dias, Melanie Kershaw, Jeremy M Kirk, Wolfgang Högler, Ruth E Krone, Michael W O'Reilly, Wiebke Arlt
OBJECTIVE: Androgen excess in childhood is a common presentation and may signify sinister underlying pathology. Data describing its patterns and severity are scarce, limiting the information available for clinical decision processes. Here, we examined the differential diagnostic value of serum dehydroepiandrosterone sulfate (DHEAS), androstenedione (A4), and testosterone (T) in childhood androgen excess. DESIGN: Retrospective review of all children undergoing serum androgen measurement at a single center over 5 years...
December 1, 2018: European Journal of Endocrinology
Elizabeth R May, Linda A Frank, Mee-Ja M Sula
BACKGROUND: Schipperkes develop bilaterally symmetrical alopecia preceded by lightening of the hair coat not associated with systemic clinical signs. The alopecia is presumptively diagnosed as Alopecia X but has never been investigated. HYPOTHESIS/OBJECTIVES: The purpose of this study was to describe clinical features, histopathological and laboratory abnormalities associated with symmetrical, noninflammatory alopecia in schipperkes. ANIMALS: Three healthy and eight affected schipperkes...
December 17, 2018: Veterinary Dermatology
M R Nagaraja, Satya Prakash Gubbala, C R Wilma Delphine Silvia, Ramars Amanchy
We aimed to survey the monogenic causes of disorders of sex development (DSD) and thereby its prevalence in India. This study revealed mutations resulting in androgen insensitivity syndrome, 5α-reductase type 2 deficiency, and gonadal dysgenesis were commonly reported. Intriguingly, AR deficits were the most prevalent (32 mutations) and of 11/26 missense mutations were in exons 4-8 (encoding ligand binding domain). The unique features of SRD5A2 defects were p.R246Q (most prevalent) and p.G196S could be mutational hotspots, dual gene defects (p...
December 14, 2018: Systems Biology in Reproductive Medicine
Xinchen Wu, Mengqi Zhang
Osteoporosis is liable to affect patients with gonadal hormone deficiency, and a supplement of androgens may be used to increase bone density of patients with osteoporosis. Since the androgens currently used may cause severe side effects, it is useful to investigate the effect of other androgens and progestin on bone improvement. The aim of the current study was to investigate the effects of pregnenolone (Preg), androstenedione (AD), etiocholanolone (Etio), androsterone (An), nandrolone (NA) and testosterone (T) on the proliferation and differentiation of osteoblasts for potential clinical applications...
December 2018: Experimental and Therapeutic Medicine
Sandra Rinne Dahl, Ingrid Nermoen, Ingeborg Brøndstad, Eystein Sverre Husebye, Kristian Løvås, Per Medbøe Thorsby
Immunoassays of steroid hormones are still used in the diagnosis and monitoring of patients with congenital adrenal hyperplasia. However, cross-reactivity between steroids can give rise to falsely elevated steroid levels. Here we compare the use of immunoassays and liquid chromatography-tandem mass spectrometry (LC-MS/MS) in the monitoring of patients with classic 21-hydroxylase deficiency (21OHD). Steroid profiles in different mutation groups (genotypes) were also compared. Fifty-five patients with classic 21OHD (38 women) were studied...
December 1, 2018: Endocrine Connections
Alexandra Efthymiadou, Maria Bogiatzidou, Dimitra Kritikou, Dionisios Chrysis
OBJECTIVES: To assess whether the serum levels of anti-Müllerian hormone (AMH) are increased in girls with premature adrenarche because they are at a higher risk of developing polycystic ovary syndrome (PCOS) later in life. STUDY DESIGN: We measured serum levels of AMH, dehydroepiandrosterone sulfate (DHEAS), testosterone, sex hormone binding globulin, androstenedione, and 17-hyroxyprogesterone in 89 girls with premature adrenarche aged 6.98 ± 1.60 years, and in 55 prepubertal normal girls aged 6...
October 24, 2018: Journal of Pediatrics
Javaid Iqbal, Alyssa Kahane, Alison L Park, Tianhua Huang, Wendy S Meschino, Joel G Ray
OBJECTIVE: Some maternal hormone levels in pregnancy are associated with a higher risk of breast and ovarian cancer. This study systematically assessed the association between blood hormone levels measured in pregnancy and future risk of these cancers. METHODS: Two reviewers independently conducted a literature search of MEDLINE and EMBASE databases from January 1970 to August 2017. Studies were included that measured one or more serum hormone levels in pregnancy and later assessed for cancer...
October 24, 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
Kirsty A Walters, Stephanie Eid, Melissa C Edwards, Rachel Thuis-Watson, Reena Desai, Mark Bowman, Anthony J Marren, David J Handelsman
RESEARCH QUESTION: Can IVF outcomes be predicted from the steroid profile generated by liquid chromatography-mass spectrometry (LC-MS/MS) from follicular fluid collected from a single dominant follicle and serum after ovarian stimulation. DESIGN: Prospective observational cohort study in which serum and follicular fluid were collected from women and used to generate steroid profiles by LC-MS/MS. A total of 93 consecutive women enrolled for IVF treatment were recruited at the Fertility Unit, Royal Prince Alfred Women and Babies Hospital, Sydney between September 2014 and July 2015...
November 22, 2018: Reproductive Biomedicine Online
Lisal J Folsom, Mariam Hjaige, Jiayan Liu, Erica A Eugster, Richard J Auchus
17β-hydroxysteroid dehydrogenase type 3 (17βHSD3) deficiency is an autosomal recessive disorder of male sex development that results in defective testosterone biosynthesis. Although mutations in the cognate HSD17B3 gene cause a spectrum of phenotypic manifestations, the majority of affected patients are genetic males having female external genitalia. Many cases do not present until puberty, at which time peripheral conversion of androgen precursors causes progressive virilization. Measurement of the testosterone-to-androstenedione ratio is useful to screen for 17βHSD3 deficiency, and genetic analysis can confirm the diagnosis...
November 30, 2018: Molecular and Cellular Endocrinology
Katarzyna Kisielewska, Edyta Rytelewska, Marlena Gudelska, Marta Kiezun, Kamil Dobrzyn, Karol Szeszko, Kinga Bors, Joanna Wyrebek, Tadeusz Kaminski, Nina Smolinska
The aim of this study was to investigate the effect of orexin B (OXB) on progesterone (P4) and androstenedione (A4) secretion by porcine endometrial and myometrial tissue explants and on the expression of key steroidogenic proteins and enzymes involved in steroid production. The hormones secretion and the expression of steroidogenic acute regulatory protein (StAR), P450 side-chain cleavage enzyme (CYP11A1) and 3β-hydroxysteroid dehydrogenase (HSD3B1) was analyzed on days 10 to 11, 12 to 13, 15 to 16, 27 to 28 of pregnancy and during the luteal phase of the oestrous cycle (days 10 to 11)...
December 2, 2018: Journal of Animal Science
Rosie Cornish, Anne Cathrine Staff, Andy Boyd, Debbie A Lawlor, Steinar Tretli, Gary Bradwin, Thomas F McElrath, Marianne Hyer, Robert N Hoover, Rebecca Troisi
PURPOSE: Breast cancer risk associated with pregnancy characteristics may be mediated by maternal hormones or angiogenic factors. METHODS: We conducted a prospective breast cancer case-control study among women in the Avon Longitudinal Study of Parents and Children (ALSPAC) and Norwegian Mother and Child Cohort Study (MoBa) related to maternal pregnancy prolactin (n = 254 cases and 374 controls), placental growth factor (PlGF, n = 252 and 371), soluble fms-like tyrosine kinase-1 (sFlt-1, n = 118 and 240) and steroid hormone concentrations (ALSPAC only, n = 173 and 171)...
December 1, 2018: Cancer Causes & Control: CCC
J Heráček, V Sobotka, L Kolátorová, J Kočárek, R Hampl
Five intratesticular sex steroids (testosterone, dihydrotestosterone, androstenedione, estradiol and epitestosterone) along with six serum hormones (LH, FSH, prolactin, SHBG, testosterone and estradiol) were determined in 84 non-obstructive azoospermic men, in order to evaluate to what extent serum and testicular tissue as well as individual hormones in the same material mutually correlate. With exception of androstenedione, tight correlations were found among tissue content of sex steroids, while only weak correlation was recorded between serum and testicular concentrations of major sex steroids testosterone and estradiol...
November 28, 2018: Physiological Research
L Kolatorova, J Vitku, A Vavrous, R Hampl, K Adamcova, M Simkova, A Parizek, L Starka, M Duskova
Endocrine disruptors (EDs) are known to have harmful effects on the human endocrine system; special effort is actually given to the exposure during pregnancy. Humans are usually exposed to a mixture of EDs, which may potentiate or antagonize each other, and the combined effect may be difficult to estimate. The main phthalate monoesters monoethyl-, mono-n-butyl-, monoisobutyl-, monobenzyl-, mono-(2-ethylhexyl)-, mono-(2-ethyl-5-hydroxyhexyl)- and mono-(2-ethyl-5-oxohexyl) phthalate were determined in 18 maternal (37th week of pregnancy) and cord plasma samples using liquid chromatography-tandem mass spectrometry...
November 28, 2018: Physiological Research
M Dušková, L Kolátorová, L Stárka
The androgens dehydroepiandrosterone sulfate, dehydro-epiandrosterone, androstenedione and testosterone are routinely assessed in women, and circulating levels of these androgens reflect their production. These androgens are measured in most laboratories using various immuno-analytical methods. Recently, however, androgen assays have begun to be performed using gas or liquid chromatography combined with mass spectrometry. To better understand the difficulties and issues of androgen laboratory diagnostics, it is important to assess each of the methods used, how and why they were introduced into practice, and their advantages, limits, historic milestones and current status...
November 28, 2018: Physiological Research
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