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https://www.readbyqxmd.com/read/28228318/endocrine-and-cardiometabolic-cord-blood-characteristics-of-offspring-born-to-mothers-with-and-without-polycystic-ovary-syndrome
#1
Nadine M P Daan, Maria P H Koster, Regine P Steegers-Theunissen, Marinus J C Eijkemans, B C J M Fauser
OBJECTIVE: To compare the endocrine and cardiometabolic cord blood characteristics of offspring of mothers with polycystic ovary syndrome (PCOS) with those of healthy controls. DESIGN: Cross-sectional case control study. SETTING: University medical centers. PATIENT(S): Offspring from mothers with PCOS (n = 61) and healthy controls (n = 82). INTERVENTION(S): Cord blood withdrawal from neonates. MAIN OUTCOME MEASURE(S): Cord blood estradiol, androstenedione, dehydroepiandrosterone sulfate (DHEAS), testosterone, sex hormone-binding globulin, free androgen index (FAI), insulin, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, c-reactive protein, adiponectin, and leptin...
January 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28190856/virilism-and-ectopic-expression-of-hsd17b5-in-mature-cystic-teratoma
#2
Yohei Kawaguchi, Hiroko Mizuno, Mai Horikawa, Mayuko Kano, Kengo Yamada, Fumiko Yamakawa, Takashi Maekawa, Yuto Yamazaki, Keely M McNamara, Hironobu Sasano, Masayuki Hayashi
Mature cystic teratoma (MCT) is rarely involved in the overproduction of steroid hormones in contrast to sex cord stromal tumors. A 31-year-old woman visited our hospital with hirsutism, hoarseness, and hair loss from the scalp. Serum testosterone and free-testosterone levels were 7.3 ng/ml and 2.3 pg/ml, respectively, which were markedly in excess of the age adjusted female standard levels. Basal blood levels of steroid hormones and serum levels of 17-hydroxyprogesterone at 1 h after intravenous injection of adrenocorticotropic hormone demonstrated that 21-hydroxylase deficiency was not the underlying cause of her virilization...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28178574/is-acne-a-sign-of-androgen-excess-disorder-or-not
#3
Gulsum Uysal, Yılmaz Sahin, Kursad Unluhizarci, Ayten Ferahbas, Semih Zeki Uludag, Ercan Aygen, Fahrettin Kelestimur
OBJECTIVE: Acne is not solely a cosmetic problem. The clinical importance of acne in the estimation of androgen excess disorders is controversial. Recently, the Amsterdam ESHRE/ASRM-sponsored third PCOS Consensus Workshop Group suggested that acne is not commonly associated with hyperandrogenemia and therefore should not be regarded as evidence of hyperandrogenemia. Our aim was to investigate whether acne is a sign of androgen excess disorder or not. STUDY DESIGN: This is a cross sectional study that was performed in a university hospital involving 207 women, aged between 18 and 45 years, suffering mainly from acne...
January 23, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28164514/testosterone-measured-with-an-automatic-immunoassay-compares-reasonably-well-to-results-obtained-by-lc-ms-ms
#4
Cindy S Knudsen, Carsten S Hoejskov, Holger J Moller, Ebba Nexo
BACKGROUND: Previous studies have reported problems measuring testosterone with immunological assays. Here we explore an automatic second generation immunoassay compared to a LC-MS/MS method. METHODS: We collected blood samples from 76 women and measured testosterone, progesterone, gender hormonebinding globulin (SHBG), and albumin employing Cobas e601/c501. Testosterone, androstenedione (andro), dehydroepiandrosterone sulphate (DHEAS), and 17-hydroxyprogesterone (17-OHP) concentrations were measured employing LC-MS/MS...
October 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28163867/umbilical-cord-blood-androgen-levels-and-asd-related-phenotypes-at-12-and-36%C3%A2-months-in-an-enriched-risk-cohort-study
#5
Bo Y Park, Brian K Lee, Igor Burstyn, Loni P Tabb, Jeff A Keelan, Andrew J O Whitehouse, Lisa A Croen, Margaret D Fallin, Irva Hertz-Picciotto, Owen Montgomery, Craig J Newschaffer
BACKGROUND: Autism spectrum disorder (ASD) affects more than 1% of children in the USA. The male-to-female prevalence ratio of roughly 4:1 in ASD is a well-recognized but poorly understood phenomenon. An explicit focus on potential etiologic pathways consistent with this sex difference, such as those involving prenatal androgen exposure, may help elucidate causes of ASD. Furthermore, the multi-threshold liability model suggests that the genetic mechanisms in females with ASD may be distinct and may modulate ASD risk in families with female ASD in the pedigree...
2017: Molecular Autism
https://www.readbyqxmd.com/read/28163019/interrelationships-between-ovarian-follicles-grown-in-culture-and-possible-mediators
#6
Alexander V Sirotkin, Iveta Florkovičová Koničková, Hans-Jorg Schaeffer, Jozef Laurincik, Abdel Halim Harrath
Dominance or cooperation between ovarian follicles can determine the number of ovulations and fecundity, but interrelationships between follicles in mono- and poly-ovulatory species and their mechanisms are poorly understood. The goals of this work were to determine the existence and compare the character of mutual influence of cultured ovarian follicles from a mono-ovulatory species (cow) with established follicular dominance with those from a poly-ovulatory species (pig), in which interrelationship between follicles remain unknown, and to examine the role of ovarian cell proliferation, the insulin-like growth factor I (IGF-I)- oxytocin (OT) system, and steroid hormones in mediating interrelationships among ovarian follicles...
February 2, 2017: Reproductive Biology
https://www.readbyqxmd.com/read/28148717/blockage-of-androgen-and-administration-of-estrogen-induce-transdifferentiation-of-testis-into-ovary
#7
Hongjuan Shi, Tian Gao, Zhilong Liu, Lina Sun, Xiaolong Jiang, Lili Chen, Deshou Wang
Induction of sex reversal of XY fish has been restricted to the sex undifferentiated period. In the present study, differentiated XY tilapia were treated with Trilostane (TR), Metopirone (MN) and Glycyrrhetinic acid (GA) (inhibitor of 3β-HSD, Cyp11b2 and 11β-HSD respectively) alone, or in combination with 17β-estrodiol (E2) from 30 to 90 dah (days after hatching). At 180 dah, E2 alone resulted in 8.3%, and TR, MN and GA alone resulted in no secondary sex reversal (SSR), while TR+E2, MN+E2 and GA+E2 resulted in 88...
February 1, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28128864/aliphatic-c-c-bond-cleavage-of-%C3%AE-hydroxy-ketones-by-a-dioxygen-derived-nucleophilic-iron-oxygen-oxidant
#8
Tapan Kanti Paine, Shrabanti Bhattacharya, Rubina Rahaman, Sayanti Chatterjee
A nucleophilic iron-oxygen oxidant, formed in situ in the reaction between an iron(II)-benzilate complex and O2, oxidatively cleaves the aliphatic C-C bonds of α-hydroxy ketones. In the cleavage reaction, α-hydroxy ketones without any α-C-H bond afford a 1:1 mixture of carboxylic acid and ketone. Isotope labeling studies establish that one of the oxygen atoms from dioxygen is incorporated into the carboxylic acid product. Furthermore, the iron(II) complex cleaves an aliphatic C-C bond of, 17-α-hydroxyprogesterone, affording androstenedione and acetic acid...
January 27, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28126344/characterization-and-longitudinal-monitoring-of-serum-androgens-and-glucocorticoids-during-normal-pregnancy-in-the-killer-whale-orcinus-orca
#9
Todd R Robeck, Karen J Steinman, Justine K O'Brien
The secretory patterns of testosterone (T), androstenedione (A4), dehydroepiandrosterone (DHEA), cortisol (C), and corticosterone (Co) were characterized throughout 28 normal pregnancies until two-months post-partum in eleven killer whales. Effects of fetal sex, dam parity or age, and season were evaluated across either day post-conception (DPC), stage of pregnancy (PRE, EARLY, MID, LATE, POST) or indexed month post-conception (IMPC) using a mixed model linear regression with animal ID and pregnancy number as the random variables...
January 23, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28117267/androgens-and-psychosocial-factors-related-to-sexual-dysfunctions-in-premenopausal-women
#10
Sarah Wåhlin-Jacobsen, Ellids Kristensen, Anette Tønnes Pedersen, Nanna Cassandra Laessøe, Arieh S Cohen, David M Hougaard, Marika Lundqvist, Annamaria Giraldi
INTRODUCTION: The female sexual response is complex and influenced by several biological, psychological, and social factors. Testosterone is believed to modulate a woman's sexual response and desire, because low levels are considered a risk factor for impaired sexual function, but previous studies have been inconclusive. AIM: To investigate how androgen levels and psychosocial factors are associated with female sexual dysfunction (FSD), including hypoactive sexual desire disorder (HSDD)...
January 20, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28104344/in%C3%A2-vitro-effect-of-4-nonylphenol-on-human-chorionic-gonadotropin-hcg-stimulated-hormone-secretion-cell-viability-and-reactive-oxygen-species-generation-in-mice-leydig-cells
#11
Tomáš Jambor, Eva Tvrdá, Eva Tušimová, Anton Kováčik, Jana Bistáková, Zsolt Forgács, Norbert Lukáč
Nonylphenol is considered an endocrine disruptor and has been reported to affect male reproductive functions. In our in vitro study, we evaluated the effects of 4-nonylphenol (4-NP) on cholesterol levels, hormone formation and viability in cultured Leydig cells from adult ICR male mice. We also determined the potential impact of 4-NP on generation of reactive oxygen species (ROS) after 44 h of cultivation. The cells were cultured with addition of 0.04; 0.2; 1.0; 2.5 and 5.0 μg/mL of 4-NP in the present of 1 IU/mL human chorionic gonadotropin (hCG) and compared to the control...
March 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28103902/relationship-between-crown-like-structures-and-sex-steroid-hormones-in-breast-adipose-tissue-and-serum-among-postmenopausal-breast-cancer-patients
#12
Maeve Mullooly, Hannah P Yang, Roni T Falk, Sarah J Nyante, Renata Cora, Ruth M Pfeiffer, Derek C Radisky, Daniel W Visscher, Lynn C Hartmann, Jodi M Carter, Amy C Degnim, Frank Z Stanczyk, Jonine D Figueroa, Montserrat Garcia-Closas, Jolanta Lissowska, Melissa A Troester, Stephen M Hewitt, Louise A Brinton, Mark E Sherman, Gretchen L Gierach
BACKGROUND: Postmenopausal obesity is associated with increased circulating levels of androgens and estrogens and elevated breast cancer risk. Crown-like structures (CLS; microscopic foci of dying adipocytes surrounded by macrophages) are proposed to represent sites of increased aromatization of androgens to estrogens. Accordingly, we examined relationships between CLS and sex-steroid hormones in breast adipose tissue and serum from postmenopausal breast cancer patients. METHODS: Formalin-fixed paraffin embedded benign breast tissues collected for research from postmenopausal women (n = 83) diagnosed with invasive breast cancer in the Polish Breast Cancer Study (PBCS) were evaluated...
January 19, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28099123/hyperandrogenemia-in-women-with-polycystic-ovary-syndrome-prevalence-characteristics-and-association-with-body-mass-index
#13
Eleni Alexiou, Erifili Hatziagelaki, Vasilios Pergialiotis, Charalampos Chrelias, Dimitrios Kassanos, Charalampos Siristatidis, Giannoula Kyrkou, Maria Kreatsa, Eftihios Trakakis
BACKGROUND: Hyperandrogenemia is one of the major diagnostic features for the diagnosis of polycystic ovary syndrome (PCOS). The aim of this study was to estimate the prevalence and the characteristics of hyperandrogenemia in women with PCOS and to investigate the association of clinical and biochemical characteristics with body mass index (BMI) according to the presence of hyperandrogenemia. MATERIALS AND METHODS: We studied 266 women diagnosed with PCOS. Hyperandrogenemia was defined by testosterone (T) and/or free testosterone (FT) and/or ∆4 androstenedione (Δ4-A) higher than 75% of the upper limits of each hormone...
January 18, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28098892/metabolomics-study-on-primary-dysmenorrhea-patients-during-the-luteal-regression-stage-based-on-ultra-performance-liquid-chromatography-coupled-with-quadrupole%C3%A2-time%C3%A2-of%C3%A2-flight-mass-spectrometry
#14
Ling Fang, Caiyun Gu, Xinyu Liu, Jiabin Xie, Zhiguo Hou, Meng Tian, Jia Yin, Aizhu Li, Yubo Li
Primary dysmenorrhea (PD) is a common gynecological disorder which, while not life‑threatening, severely affects the quality of life of women. Most patients with PD suffer ovarian hormone imbalances caused by uterine contraction, which results in dysmenorrhea. PD patients may also suffer from increases in estrogen levels caused by increased levels of prostaglandin synthesis and release during luteal regression and early menstruation. Although PD pathogenesis has been previously reported on, these studies only examined the menstrual period and neglected the importance of the luteal regression stage...
January 13, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28096494/reproductive-performance-primarily-depends-on-the-female-genotype-in-a-two-factorial-breeding-experiment-using-high-fertility-mouse-lines
#15
Martina Langhammer, Marten Michaelis, Michaela F Hartmann, Stefan A Wudy, Alexander Sobczak, Gerd Nürnberg, Norbert Reinsch, Jennifer Schön, Joachim M Weitzel
Mouse models showing an improved fertility phenotype are barely described in the literature. In the present study, we further characterized two outbred mouse models that have been selected for the phenotype 'high fertility' for more than 177 generations (fertility lines (FL) 1 and 2). In order to delineate the impact of males and females on fertility parameters, we performed a two-factorial breeding experiment by mating males and females of the three different genotypes (FL1, FL2, unselected control (Ctrl)) in all 9 possible combinations...
March 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28090348/changes-in-hba1c-and-circulating-and-adipose-tissue-androgen-levels-in-overweight-obese-women-with-polycystic-ovary-syndrome-in-response-to-electroacupuncture
#16
E Stener-Victorin, M Maliqueo, M Soligo, V Protto, L Manni, E Jerlhag, M Kokosar, A Sazonova, C J Behre, M Lind, C Ohlsson, K Højlund, A Benrick
AIM: Insulin sensitivity is ~40% lower in women with polycystic ovary syndrome (PCOS) than in controls. We tested the hypothesis that 5 weeks of electroacupuncture treatment improves glucose regulation and androgen levels in overweight/obese women with PCOS. MATERIAL AND METHODS: Seventeen women with PCOS, aged 18 to 38 years, with a body mass index (BMI) ≥25 kg/m(2) and diagnosed with PCOS were included in this experimental and feasibility study and subjected to five weeks of electroacupuncture treatments three times/week...
December 2016: Obesity Science & Practice
https://www.readbyqxmd.com/read/28076306/parallel-diurnal-fluctuation-of-testosterone-androstenedione-dehydroepiandrosterone-and-17ohprogesterone-as-assessed-in-serum-and-saliva-validation-of-a-novel-liquid-chromatography-tandem-mass-spectrometry-method-for-salivary-steroid-profiling
#17
Marco Mezzullo, Alessia Fazzini, Alessandra Gambineri, Guido Di Dalmazi, Roberta Mazza, Carla Pelusi, Valentina Vicennati, Renato Pasquali, Uberto Pagotto, Flaminia Fanelli
BACKGROUND: Salivary androgen testing represents a valuable source of biological information. However, the proper measurement of such low levels is challenging for direct immunoassays, lacking adequate accuracy. In the last few years, many conflicting findings reporting low correlation with the serum counterparts have hampered the clinical application of salivary androgen testing. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) makes it possible to overcome previous analytical limits, providing new insights in endocrinology practice...
January 11, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28065637/the-steroid-metabolite-16-%C3%AE-oh-androstenedione-generated-by-cyp21a2-serves-as-a-substrate-for-cyp19a1
#18
J Neunzig, M Milhim, L Schiffer, Y Khatri, J Zapp, A Sánchez-Guijo, M F Hartmann, S A Wudy, R Bernhardt
The 21-hydroxylase (CYP21A2) is a steroidogenic enzyme crucial for the synthesis of mineralo- and glucocorticoids. It is described to convert progesterone as well as 17-OH-progesterone, through a hydroxylation at position C21, into 11-deoxycorticosterone (DOC) and 11-deoxycortisol (RSS), respectively. In this study we unraveled CYP21A2 to have a broader steroid substrate spectrum than assumed. Utilizing a reconstituted in vitro system, consisting of purified human CYP21A2 and human cytochrome P450 reductase (CPR) we demonstrated that CYP21A2 is capable to metabolize DOC, RSS, androstenedione (A4) and testosterone (T)...
March 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28051945/sex-specific-effects-of-high-yolk-androgen-levels-on-constitutive-and-cell-mediated-immune-responses-in-nestlings-of-an-altricial-passerine
#19
Jaime Muriel, Lorenzo Pérez-Rodríguez, Manuel E Ortiz-Santaliestra, Marisa Puerta, Diego Gil
Avian embryos are exposed to yolk androgens that are incorporated into the egg by the ovulating female. These steroids can affect several aspects of embryo development, often resulting in increases in overall size or the speed of growth of different traits. However, several studies suggest that they also entail immune costs to the offspring. In this study, we explored whether variation in yolk androgen concentration affected several measures of the constitutive and cell-mediated immune axes in the spotless starling (Sturnus unicolor)...
January 2017: Physiological and Biochemical Zoology: PBZ
https://www.readbyqxmd.com/read/28044214/associations-of-obesity-and-physical-activity-with-serum-and-intratumoral-sex-steroid-hormone-levels-among-postmenopausal-women-with-breast-cancer-analysis-of-paired-serum-and-tumor-tissue-samples
#20
Yoichiro Kakugawa, Hiroshi Tada, Masaaki Kawai, Takashi Suzuki, Yoshikazu Nishino, Seiki Kanemura, Takanori Ishida, Noriaki Ohuchi, Yuko Minami
PURPOSE: It has been hypothesized that intratumoral estrogens may play important roles in the growth of breast cancer. However, few studies have investigated such intratumoral hormones, or their association with risk factors of breast cancer. METHODS: In this cross-sectional study, hormone levels in paired serum and tumor tissue samples from 146 postmenopausal women with breast cancer were measured by liquid chromatography-tandem mass spectrometry and compared between estrogen/progesterone (ER/PgR) subtypes...
January 2, 2017: Breast Cancer Research and Treatment
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