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https://www.readbyqxmd.com/read/29332595/new-bis-pyrazolones-as-potential-leads-for-ros-inhibition-environment-friendly-green-synthesis-structural-characterization-and-in-vitro-studies
#1
Sahar Yousuf, Khalid Mohammed Khan, Uzma Salar, Almas Jabeen, Shakil Ahmed, Munira Taj Muhammad, Aisha Faheem, Shahnaz Perveen
BACKGROUND: Pyrazolones have identified as significant antioxidant agents and many marketed and clinically prescribed NSAIDs have pyrazolone ring as main scaffold. METHOD: Keeping in consideration the antioxidant potential of pyrazolone scaffold, new bis-pyrazolones 3-30 were synthesized by a green and enviroment friendly reaction route, in which two equivalents of 1-(4-chlorophenyl)-3-methyl-1H-pyrazol-5-ol were treated with one equivalent of benzaldehyde derivatives without any catalyst...
January 12, 2018: Medicinal Chemistry
https://www.readbyqxmd.com/read/29332199/analysis-of-the-data-on-pregnancy-and-lactation-provided-by-patient-information-leaflets-of-anti-rheumatic-drugs-in-argentina
#2
Miguel Ormaza Sabando, Maira Arias Saavedra, Gabriel Sequeira, Eduardo Kerzberg
To analyse the level of consistency and updating of the information on pregnancy and lactation provided by patient information leaflets (PILs) of the antirheumatic drugs approved in Argentina. Inconsistencies between the 2016 EULAR Task Force recommendations on the use of anti-rheumatic drugs during pregnancy and lactation and the information provided by PILs of the same drugs approved in Argentina were analysed along with inconsistencies within the PILs of different registered trademarks of these drugs. Eighty-eight PILs of 32 drugs were analysed...
January 13, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29329551/efficacy-and-safety-of-combined-treatment-of-miniscalpel-acupuncture-and-non-steroidal-anti-inflammatory-drugs-an-assessor-blinded-randomized-controlled-pilot-study
#3
Seungah Jun, Jung Hee Lee, Han Mi Gong, Yeon-Joong Chung, Ju-Ran Kim, Chung A Park, Seong Hun Choi, Geon-Mok Lee, Hyun-Jong Lee, Jae Soo Kim
BACKGROUND: Chronic neck pain is a common musculoskeletal disease during the lifespan of an individual. With an increase in dependence on computer technology, the prevalence of chronic neck pain is expected to rise and this can lead to socioeconomic problems. We have designed the current pilot study to evaluate the efficacy and safety of miniscalpel acupuncture treatment combined with non-steroidal anti-inflammatory drugs (NSAIDs) in patients with chronic neck pain. METHODS: This seven-week clinical trial has been designed as an assessor-blinded, randomized controlled trial with three parallel arms...
January 12, 2018: Trials
https://www.readbyqxmd.com/read/29327635/an-open-label-clinical-trial-of-thalidomide-in-nsaids-refractory-ankylosing-spondylitis
#4
Minhaj Rahim Choudhury, M Masudul Hassan, M Ekramul Kabir, M Golam Rabbani, Syed Atiqul Haq, Md Kasedur Rahman
No abstract text is available yet for this article.
January 12, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29326169/dual-cyclooxygenase-fatty-acid-amide-hydrolase-inhibitor-exploits-novel-binding-interactions-in-the-cyclooxygenase-active-site
#5
Michael C Goodman, Shu Xu, Carol A Rouzer, Surajit Banerjee, Kebreab Ghebreselasie, Marco Migliore, Daniele Piomelli, Lawrence J Marnett
The cyclooxygenases COX-1 and COX-2 oxygenate arachidonic acid (AA) to prostaglandin H2 (PGH2). COX-2 also oxygenates the endocannabinoids, 2-arachidonoylglycerol (2-AG) and arachidonoylethanolamide (AEA), to the corresponding PGH2 analogs. Both enzymes are targets of nonsteroidal anti-inflammatory drugs (NSAIDs), but NSAID-mediated COX inhibition is associated with gastrointestinal toxicity. One potential strategy to counter this toxicity is to also inhibit fatty acid amide hydrolase (FAAH), which hydrolyzes bioactive fatty acid ethanolamides (FAEs) into fatty acids and ethanolamine...
January 11, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29324184/effects-of-non-steroidal-anti-inflammatory-drugs-on-serum-proinflammatory-cytokines-in-the-treatment-of-ankylosing-spondylitis
#6
Yong Yan, Tuan-Mao Guo, Chao Zhu
OBJECTIVE: This study was conducted to investigate the correlation between levels of serum proinflammatory cytokines and the clinical efficacy of non-steroidal anti-inflammatory drugs (NSAIDs) in patients with ankylosing spondylitis (AS). METHODS: A total of 148 AS patients were selected and received NSAID treatment. ELISA was used to assess cytokine levels, and patients were assigned into positively effective, effective, moderately effective, and ineffective groups...
January 11, 2018: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/29319909/inhibitory-effects-of-sulfonylureas-and-non-steroidal-anti-inflammatory-drugs-on-in-vitro-metabolism-of-canagliflozin-in-human-liver-microsomes
#7
Sara Algeelani, Dalal Alkhelb, David J Greenblatt
Canagliflozin, used to treat type 2 diabetes mellitus (T2DM), is commonly co-administered with sulfonylureas. The objective of the present study was to evaluate the possible inhibitory effect of sulfonylureas and non-steroidal anti-inflammatory drugs (NSAIDs) on canagliflozin metabolism in vitro. Three sulfonylurea derivatives were evaluated as inhibitors: chlorpropamide, glimepiride, and gliclazide. Two other NSAIDs were used as positive control inhibitors: niflumic acid and diclofenac. The rate of formation of canagliflozin metabolites was determined by HPLC analysis of vitro incubations of canagliflozin as a substrate with and without inhibitors, using human liver microsomes (HLMs)...
January 10, 2018: Biopharmaceutics & Drug Disposition
https://www.readbyqxmd.com/read/29319718/effects-of-periarticular-injection-on-analgesic-effects-and-nsaid-use-in-total-knee-arthroplasty-and-total-hip-arthroplasty
#8
Wen-Rui Ban, Ery-Ang Zhang, Lei-Feng Lv, Xiao-Qian Dang, Chen Zhang
OBJECTIVES: This study examined periarticular multimodal drug injection and the use of nonsteroidal anti-inflammatory drugs for an early analgesic effect after total knee arthroplasty and total hip arthroplasty. Patient satisfaction and benefits from the treatment were also assessed. METHODS: A total of 110 patients who were scheduled to undergo total knee arthroplasty and 86 patients who were scheduled to undergo total hip arthroplasty were divided into two groups, the study group and the control group...
December 2017: Clinics
https://www.readbyqxmd.com/read/29317721/sex-differences-in-risk-factors-of-uncomplicated-colonic-diverticulosis-in-a-metropolitan-area-from-northern-china
#9
Fang Yang, Yanmin Zheng, Xihui Jiang, Zhengyan Su, Ya Wang, Lin Lin, Houning Lv, Jie Zhang, Jingwen Zhao, Bangmao Wang, Kui Jiang, Chao Sun
As the world's most populated and rapidly aging country, there is limited information on sex-related differences in factors regarding uncomplicated colonic diverticulosis in China. We aimed to investigate sex differences in individual risk factor in a northern metropolis. Patients with colonic diverticulosis who underwent indicated colonoscopy were queried with respect to medical history and demographic features. Demographic information, life style factors and co-morbidities were retrieved from a prospective dataset...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29316945/the-implementation-of-academic-detailing-and-its-effectiveness-on-appropriate-prescribing-of-pain-relief-medication-a-real-world-cluster-randomized-trial-in-belgian-general-practices
#10
Robin Bruyndonckx, Veronique Verhoeven, Sibyl Anthierens, Koen Cornelis, Katelijne Ackaert, Birgit Gielen, Samuel Coenen
BACKGROUND: In Belgium, the debate about the effect of the national academic detailing service (ADS) on prescribing quality in general practice is ongoing. In order to evaluate both the implementation strategies of the ADS and its effectiveness on appropriate prescribing of pain relief medication, we conducted a real-world cluster randomized controlled trial (cRCT). METHODS: In a pragmatic cRCT, all Belgian general practices previously visited by Farmaka were assessed for eligibility and randomized...
January 10, 2018: Implementation Science: IS
https://www.readbyqxmd.com/read/29316620/could-aspirin-and-diets-high-in-fiber-act-synergistically-to-reduce-the-risk-of-colon-cancer-in-humans
#11
REVIEW
Pan Pan, Yi-Wen Huang, Kiyoko Oshima, Martha Yearsley, Jianying Zhang, Jianhua Yu, Mark Arnold, Li-Shu Wang
Early inhibition of inflammation suppresses the carcinogenic process. Aspirin is the most commonly used non-steroid anti-inflammatory drugs (NSAIDs), and it irreversibly inhibits cyclooxygenase-1 and -2 (COX1, COX2). Multiple randomized clinical trials have demonstrated that aspirin offers substantial protection from colon cancer mortality. The lower aspirin doses causing only minimal gastrointestinal disturbance, ideal for long-term use, can achieve only partial and transitory inhibition of COX2. Aspirin's principal metabolite, salicylic acid, is also found in fruits and vegetables that inhibit COX2...
January 6, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29314744/clinical-and-economic-implications-of-upper-gastrointestinal-adverse-events-in-asian-rheumatological-patients-on-long-term-non-steroidal-anti-inflammatory-drugs
#12
Lydia Say Lee Pok, Fatiha Hana Shabaruddin, Maznah Dahlui, Sargunan Sockalingam, Mohd Shahrir Mohamed Said, Azmillah Rosman, Ing Soo Lau, Liza Mohd Isa, Heselynn Hussein, Chin Teck Ng, Sanjiv Mahadeva
AIM: To determine the incidence and direct costs of NSAID-induced upper GI adverse events in Malaysian rheumatology patients. METHODS: A retrospective, multi-centre, cohort study of rheumatology patients on long-term NSAIDs was conducted. Clinical data of patients treated between 2010 and 2013 were collected for a 24-month follow-up period. The costs of managing upper GI adverse events were based on patient level resource use data. RESULTS: Six hundred and thirty-four patients met the inclusion criteria: mean age 53...
January 5, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29310282/use-of-polymer-inclusion-membranes-pims-as-support-for-electromembrane-extraction-of-non-steroidal-anti-inflammatory-drugs-and-highly-polar-acidic-drugs
#13
Román-Hidalgo Cristina, Martín-Valero María Jesús, Fernández-Torres Rut, Bello-López Miguel Ángel
The use of polymer inclusion membranes (PIMs) as support of 1-octanol liquid membrane in electromembrane extraction (EME) procedure is proposed. Synthesis of PIMs were optimized to a composition of 29% (w/w) of cellulose triacetate as base polymer and 71% (w/w) of Aliquat®336 as cationic carrier. Flat PIMs of 25µm thickness and 6mm diameter were used. EME protocol was implemented for the simultaneous extraction of four non-steroidal anti-inflammatory drugs (NSAIDs) (salicylic acid, ketoprofen, naproxen and ibuprofen) and four highly polar acidic drugs (anthranilic acid, nicotinic acid, amoxicillin and hippuric acid)...
March 1, 2018: Talanta
https://www.readbyqxmd.com/read/29309797/treatment-of-pandas-and-pans-a-systematic-review
#14
REVIEW
Sofia Sigra, Eva Hesselmark, Susanne Bejerot
Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) are a subtype of acute-onset obsessive-compulsive disorder (OCD) thought to be caused by an autoimmune response to group A streptococcal infection. Based on this proposed pathophysiology, alternative treatments for acute-onset OCD have been introduced, including antibiotics and immunomodulatory interventions. However, the literature on treatment of PANDAS is diverse, and clinical consensus regarding optimal treatment strategy is lacking...
January 5, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29308843/associations-between-recreational-runners-anti-inflammatory-drug-use-coping-strategies-and-time-loss-due-to-injury-and-illness-during-preparations-for-a-marathon-event
#15
Bo Tillander, Håkan Gauffin, Örjan Dahlström, Toomas Timpka
BACKGROUND: Due to the dominance of overuse injuries among runners, knowledge of how use of non-steroidal anti-inflammatory drugs (NSAIDs) and behavioural factors contribute to injury events is important. The aim of this study was to explore recreational marathon runners' strategies for coping with injury and illness, including use of drugs for control of pain and inflammation, and to investigate whether these strategies were associated with the 1-year prevalence of time-loss injury and illness...
January 4, 2018: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/29307562/anti-inflammatory-drug-use-and-progressive-supranuclear-palsy
#16
Connie Marras, Christopher R Cunningham, Jiayi Hou, James Proudfoot, David G Standaert, Jorge Juncos, David Riley, Stephen G Reich, Deborah Hall, Benzi Kluger, Yvette Bordelon, David R Shprecher, Irene Litvan
BACKGROUND: Anti-inflammatory drug use, particularly ibuprofen, has been associated with a lower risk of Parkinson's disease. Microglial activation and inflammatory cytokine expression have been shown to be pathological features of progressive supranuclear palsy. We examined the association between NSAID use and risk of PSP, disease severity and age at onset. METHODS: The ENGENE-PSP multicenter case-control study recruited incident PSP cases who met the NINDS-PSP Society diagnostic criteria and age-, sex- and race-matched controls primarily from the same geographical areas...
December 6, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29307215/-peroral-and-transdermal-application-of-non-steroidal-anti-inflammatory-drugs-nsaids-for-the-treatment-of-regional-musculoskeletal-pain-syndromes
#17
László Hodinka, Géza Bálint, Erika Budai, Pál Géher, Renáta Papp, Péter Somogyi, Sándor Szántó, Edit Vereckei
In this review the available evidences regarding the most frequently applied medication (peroral and transdermal non-steroidal anti-inflammatory agents) for the most frequent musculoskeletal complaints (regional pain syndromes) have been collected for the appropriate medical professionals who are most frequently faced with these conditions (general practitioners, rheumatologists, orthopedics, occupational and sports medicine experts). The special population at risk (with repeated and high energy overuse because of occupational or sport activities) and the pathology of their syndromes are identified...
December 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/29307210/bleeding-in-cancer-patients-and-its-treatment-a-review
#18
Candice Johnstone, Shayna E Rich
Bleeding is a common problem in cancer patients, related to local tumor invasion, tumor angiogenesis, systemic effects of the cancer, or anti-cancer treatments. Existing bleeds can also be exacerbated by medications such as bevacizumab, nonsteroidal anti-inflammatory drugs (NSAIDs), and anticoagulants. Patients may develop acute catastrophic bleeding, episodic major bleeding, or low-volume oozing. Bleeding may present as bruising, petechiae, epistaxis, hemoptysis, hematemesis, hematochezia, melena, hematuria, or vaginal bleeding...
December 18, 2017: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/29306884/retrospective-cohort-study-on-risk-of-hearing-loss-in-patients-with-rheumatoid-arthritis-using-claims-data
#19
Chung-Ming Huang, Hsuan-Ju Chen, Po-Hao Huang, Gregory J Tsay, Joung-Liang Lan, Fung-Chang Sung
OBJECTIVES: Population studies on hearing loss (HL) associated with rheumatoid arthritis (RA) are lacking. This study investigated the risk of developing HL in patients with RA using a nationwide population cohort. SETTING: The population-based insurance claims data in the Taiwan National Health Insurance Research Database. DESIGN: Retrospective cohort study followed up RA cohort and control cohort without RA frequency matched by sex, age and diagnosis year...
January 5, 2018: BMJ Open
https://www.readbyqxmd.com/read/29306760/effect-of-acetaminophen-on-osteoblastic-differentiation-and-migration-of-mc3t3-e1-cells
#20
Yoshihiro Nakatsu, Fumio Nakagawa, Sen Higashi, Tomoko Ohsumi, Shunji Shiiba, Seiji Watanabe, Hiroshi Takeuchi
BACKGROUND: N-acetyl-p-aminophenol (APAP, acetaminophen, paracetamol) is a widely used analgesic/antipyretic with weak inhibitory effects on cyclooxygenase (COX) compared to non-steroidal anti-inflammatory drugs (NSAIDs). The mechanism of action of APAP is mediated by its metabolite that activates transient receptor potential channels, including transient receptor potential vanilloid 1 (TRPV1) and TRP ankyrin 1 (TRPA1) or the cannabinoid receptor type 1 (CB1). However, the exact molecular mechanism and target underlying the cellular actions of APAP remain unclear...
July 15, 2017: Pharmacological Reports: PR
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