C M Whitfield-Cargile, H C Chung, M C Coleman, N D Cohen, A M Chamoun-Emanuelli, I Ivanov, J S Goldsby, L A Davidson, I Gaynanova, Y Ni, R S Chapkin
BACKGROUND: The equine gastrointestinal (GI) microbiome has been described in the context of various diseases. The observed changes, however, have not been linked to host function and therefore it remains unclear how specific changes in the microbiome alter cellular and molecular pathways within the GI tract. Further, non-invasive techniques to examine the host gene expression profile of the GI mucosa have been described in horses but not evaluated in response to interventions. Therefore, the objectives of our study were to (1) profile gene expression and metabolomic changes in an equine model of non-steroidal anti-inflammatory drug (NSAID)-induced intestinal inflammation and (2) apply computational data integration methods to examine host-microbiota interactions...
April 15, 2024: Microbiome