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Erbil Kilic, Mustafa Gerek, Omer Karakoc, Mehmet Gamsizkan
We investigated the effects of pepsin/hydrochloric acid and bile acids on eustachian tube function and eustachian tube mucosa in 40 Sprague-Dawley rats. The animals were randomly assigned to groups of 10: one group received pepsin/hydrochloric acid (pepsin/HCl group), another received human bile (human bile group), a third received a mixture of pepsin/HCl and human bile (combination group), and the fourth received isotonic saline solution (control group). Test solutions were applied transnasally three times a day for 10 days...
December 2018: Ear, Nose, & Throat Journal
Idrees Sher, Chris Daly, David Oehme, Ronil V Chandra, Mustafa Sher, Peter Ghosh, Julian Smith, Tony Goldschlager
STUDY DESIGN: Reliability Study. OBJECTIVE: To evaluate the applicability and reliability of 9.4T MRI in the assessment of degenerative disc disease compared to 3T MRI. SUMMARY OF BACKGROUND DATA: MRI is a reliable indicator of biochemical changes in the intervertebral disc (IVD) including hydration status, proteoglycan content and disc degeneration compared with anatomical and histological studies. High field 9.4T MRI has been shown to provide superior resolution and anatomical detail...
December 11, 2018: Spine
Hasan Erdogan, Osman Temizoz, Mustafa Koplay, Bahadir Ozturk
OBJECTIVE: Formation mechanisms and treatment of the urinary stones are different, depending on their chemical structure. Therefore, determining the stone type plays a key role in planning treatment and preventive measures. Computed tomography (CT), with the use of dual-energy technology in recent years, has made it possible to do in vivo analysis of urinary stones. In this study, we aimed to evaluate the diagnostic efficacy of dual-energy CT (DECT) and compare its results with in vitro analysis, which is accepted as a gold standard for analysis of urinary stones...
December 12, 2018: Journal of Computer Assisted Tomography
Kentaro Minagawa, Mustafa Al-Obaidi, Antonio Di Stasi
Chimeric antigen receptor (CAR)-redirected T-cells are a powerful tool for the treatment of several type of cancers; however, they can cause several adverse effects including cytokine release syndrome, off-target effects resulting in potentially fatal organ damage or even death. Particularly, for CAR T-cells redirected toward acute myeloid leukemia (AML) antigens myelosuppression can be a challenge. The previously validated inducible Caspase9 (iC9) suicide gene system is one of the approaches to control the infused cells in vivo through its activation with a nontherapeutic chemical inducer of dimerizer (CID)...
2019: Methods in Molecular Biology
Bulent Cetin, Irem Bilgetekin, Mustafa Cengiz, Ahmet Ozet
The most common site of blood-borne metastases from colorectal cancers (CRC) is the liver. Resection of (liver) metastases is a part of standard treatment of metastatic colorectal cancer. Hepatic resection is the first-line treatment of liver metastases, with 5-year survival rates between 25 and 58%. The enhanced efficacy of systemic chemotherapeutic regimens has increased tumor response rates and improved the progression-free and overall survival of patients with these malignancies. In approximately 20% of patients with initially unresectable liver metastases, the metastases may become resectable after administration of neoadjuvant chemotherapy...
December 2018: Indian Journal of Surgical Oncology
Alexandros Papachristodoulou, Rea Deborah Signorell, Beat Werner, Davide Brambilla, Paola Luciani, Mustafa Cavusoglu, Joanes Grandjean, Manuela Silginer, Markus Rudin, Ernst Martin, Michael Weller, Patrick Roth, Jean-Christophe Leroux
In glioblastoma, the benefit from temozolomide chemotherapy is largely limited to a subgroup of patients (30-35%) with tumors exhibiting methylation of the promoter region of the O6 -methylguanine-DNA methyltransferase (MGMT) gene. In order to allow more patients to benefit from this treatment, we explored magnetic resonance image-guided microbubble-enhanced low-intensity pulsed focused ultrasound (LIFU) to transiently open the blood-brain barrier and deliver a first-in-class liposome-loaded small molecule MGMT inactivator in mice bearing temozolomide-resistant gliomas...
December 8, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Ahmet Eser, Enis Ozkaya, Cigdem Yayla Abide, Tugba Eser, Gulcin Yildirim Eser, Faruk Abike, Ahter Tanay Tayyar, Mustafa Eroglu
PURPOSE: To analyze the effect of combined application of intravaginal PGE2 insert and intracervical Foley balloon catheter for induction of labor. METHODS: Patients with unfavorable cervices who required induction of labor from August 2017 to December 2017 were evaluated for the study. Three hundred and ten participants were randomly assigned to study (n:155) and control group (n:155). Nine patients in study group and seven patients in control group were excluded, because they declined to participate in the study...
December 7, 2018: Archives of Gynecology and Obstetrics
Seçil Arslansoyu Çamlar, Tülay Öztük, Alper Soylu, Mehmet Atilla Türkmen, Erdener Özer, Mustafa Olguner, Handan Güleryüz, Salih Kavukçu
No abstract text is available yet for this article.
December 10, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Seçil Arslansoyu Çamlar, Tülay Öztürk, Alper Soylu, Mehmet Atilla Türkmen, Erdener Özer, Mustafa Olguner, Handan Güleryüz, Salih Kavukcu
No abstract text is available yet for this article.
December 10, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Edme Roxana Mustafa, Diana Rodica Tudoraşcu, Alina Giucă, Despina Manuela Toader, Maria Camelia Foarfă, Ileana Puiu, Anca Maria Istrate-Ofiţeru
A 46-year-old female diagnosed several years ago with arterial hypertension and an ischemic stroke with significant recovery was admitted for dyspnea on usual physical activity and fatigue. Physical examination revealed signs of heart failure with crackles on both lung bases, distented jugular veins, accentuated pulmonic valve closure (P2) and tricuspid regurgitation murmur. Echocardiography identified a large tumor in the left atrium, suggestive of atrial myxoma, which caused a severe functional mitral stenosis and produced severe pulmonary hypertension...
2018: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
Karthik Vadamalai, Denise Sanche-Tejera, Jonathan Bress, S Shahzad Mustafa
BACKGROUND: Immunodeficiency is an underrecognized risk factor for infections, such as community-acquired pneumonia (CAP). OBJECTIVE: We evaluated patients admitted with CAP for humoral immunodeficiency. DESIGN: Prospective Cohort Study. SETTING: Inpatients. PATIENTS, INTERVENTION, AND MEASUREMENTS: We enrolled 100 consecutive patients admitted with a diagnosis of CAP from February 2017 to April 2017...
November 28, 2018: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
Mustafa Sungur, Murat Baykam, Selahattin Calışkan, Utku Lokman
Urinary retention is defined as the inability to void; frequently the patient is able to void partially, thus can not completely empty the bladder and diagnosed by increased post-void residual urine (PVR) volumes. It is usually seen in men, but a rare condition in women. The etiological factors may be neurological, anatomical, infectious or pharmacological. It can be encountered after gynecological or incontinence surgery. Urethral calculi associated with acute urinary retention in women is a very rare condition, because of the anatomic structure of female urethra...
December 2018: Turkish Journal of Emergency Medicine
Eva M Reinthaler, Elisabeth Graf, Tobias Zrzavy, Thomas Wieland, Christoph Hotzy, Chantal Kopecky, Sandra Pferschy, Christiane Schmied, Fritz Leutmezer, Mohammad Keilani, Christina M Lill, Sabine Hoffjan, Jörg T Epplen, Uwe K Zettl, Michael Hecker, Angela Deutschländer, Sven G Meuth, Mamoun Ahram, Baha Mustafa, Mohammed El-Khateeb, Carles Vilariño-Güell, A Dessa Sadovnick, Fritz Zimprich, Birgitta Tomkinson, Tim Strom, Wolfgang Kristoferitsch, Hans Lassmann, Alexander Zimprich
Objective: To ascertain the genetic cause of a consanguineous family from Syria suffering from a sterile brain inflammation mimicking a mild nonprogressive form of MS. Methods: We used homozygosity mapping and next-generation sequencing to detect the disease-causing gene in the affected siblings. In addition, we performed RNA and protein expression studies, enzymatic activity assays, immunohistochemistry, and targeted sequencing of further MS cases from Austria, Germany, Canada and Jordan...
December 2018: Neurology. Genetics
Colin M Haines, Rahul G Samtani, James T Bernatz, Mustafa Abugideiri, Joseph R O'Brien
Symptomatic far-lateral lumbar disc herniation is a less common causes of lumbar radiculopathy than paracentral or central disc herniation. Treatment of far-lateral disc herniation with a retroperitoneal, transpsoas approach and disc fragment excision has been described. However, treatment of far-lateral disc herniation using lateral lumbar interbody fusion (LLIF) without neural manipulation has not been described. We report one case in which symptom resolution was accomplished via indirect decompression with anterior column support via LLIF without disc fragment excision and review the current literature...
October 2, 2018: Curēus
Nur Atikah Mustafa, Noor Ilyani Othman, Siti Nur Atiqah Mohd Kandis, Nurul Surhana Mohd Daud
No abstract text is available yet for this article.
October 2018: Journal of Indian Prosthodontic Society
Mustafa Abbas, Peter Siordet Scolding, Abubaker Ahmed Yosif, Roa Fath El Rahman, Melka O El-Amin, Mohamed Kamal Elbashir, Nora Groce, Ahmed Hassan Fahal
Mycetoma is a neglected tropical disease endemic in tropical and subtropical countries, particularly Sudan. The disease is characterised by the triad of painless subcutaneous mass, multiple sinuses and discharge that contain grains. It is a chronic, debilitating disease most commonly affecting the feet or hands and leads to substantial morbidity, loss of function and even amputation. It predominantly affects poor, rural populations and patients typically present late with advanced disease and complications...
December 10, 2018: PLoS Neglected Tropical Diseases
Ali Rıza Kosker, Fatih Özogul, Deniz Ayas, Mustafa Durmus, Yılmaz Ucar, Joe M Regenstein, Yesim Özogul
Tetrodotoxin (TTX) levels in Lagocephalus sceleratus (Silverstripe blaasop), Lagocephalus spadiceus (Half-smooth golden pufferfish) and Lagocephalus suezensis (Suez puffer) caught in Mersin Bay in the Northeastern Mediterranean Sea were analysed using Q-TOF LC/MS. Pufferfish were caught using trawl fishing, longlining and fishing line from December 2015 to October 2016. The TTX changes in the gonads, livers, intestines, skins and muscle tissues were evaluated according to sex and season. TTX levels for L. sceleratus and L...
December 3, 2018: Chemosphere
Romina Brignardello-Petersen, Reem A Mustafa, Reed A C Siemieniuk, M Hassan Murad, Thomas Agoritsas, Ariel Izcovich, Holger J Schünemann, Gordon H Guyatt
This article presents official guidance from the Grading of Recommendations Assessments, Development, and Evaluation (GRADE) working group on how to address incoherence when assessing the certainty in the evidence from network meta-analysis. Incoherence represents important differences between direct and indirect estimates that contribute to a network estimate. Bias due to limitations in study design or publication bias, indirectness, and intransitivity may be responsible for incoherence. Addressing incoherence requires a judgment regarding the importance of the impact on the network estimate...
December 5, 2018: Journal of Clinical Epidemiology
Michael I Levinson, Matthew Hoerner, Adel Mustafa, Jay K Pahade
No abstract text is available yet for this article.
December 5, 2018: Journal of the American College of Radiology: JACR
Asif K Mustafa, Arnar Geirsson
No abstract text is available yet for this article.
November 2, 2018: Journal of Thoracic and Cardiovascular Surgery
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