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https://www.readbyqxmd.com/read/30121675/the-effects-of-hypericum-perforatum-l-on-the-proliferation-osteogenic-differentiation-and-inflammatory-response-of-mesenchymal-stem-cells-from-different-niches
#1
Ayşegül Mendi, Beyza Gökçınar Yağcı, Nurdan Saraç, Mustafa Kızıloğlu, Aysel Uğur, Duygu Uçkan, Derviş Yılmaz
The aim of this study is to demonstrate and compare the differentiation, proliferation, migration and inflammatory behavior of dental pulp- and bone marrow-derived mesenchymal stem cells (DP-MSCs and BM-MSCs) in response to a Hypericum perforatum ethanol extract. Using xCELLigence, a real-time monitoring system, a dose of 10 µg/mL was found to be the most efficient concentration for vitality. The IC50 values and doubling time were calculated. The results showed that H. perforatum L. was able to accelerate osteogenic differentiation in DP-MSCs, but calcium granulation was impaired in BM-MSCs...
August 17, 2018: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/30121627/switchable-car-t-cells-mediate-remission-in-metastatic-pancreatic-ductal-adenocarcinoma
#2
Deepak Raj, Ming-Hsin Yang, David Rodgers, Eric N Hampton, Julfa Begum, Arif Mustafa, Daniela Lorizio, Irene Garces, David Propper, James G Kench, Travis S Young, Alexandra Aicher, Christopher Heeschen
OBJECTIVE: Pancreatic ductal adenocarcinoma (PDAC) is a disease of unmet medical need. While immunotherapy with chimeric antigen receptor T (CAR-T) cells has shown much promise in haematological malignancies, their efficacy for solid tumours is challenged by the lack of tumour-specific antigens required to avoid on-target, off-tumour effects. Switchable CAR-T cells whereby activity of the CAR-T cell is controlled by dosage of a tumour antigen-specific recombinant Fab-based 'switch' to afford a fully tunable response may overcome this translational barrier...
August 18, 2018: Gut
https://www.readbyqxmd.com/read/30120689/amanah-and-muslim-identity-relationships-with-religious-and-psychological-adjustment-in-malaysia
#3
Mustafa Tekke, P J Watson, Saim Kayadibi, Zhuo Job Chen
Amanah refers to the accountability of Muslims to their community. In Malaysian Muslim university students (N = 209), an Amanah Scale predicted a stronger sense of identity along with more adaptive religious and psychosocial functioning. Multiple regression analyses identified Accountability to Society as especially influential, but Accountability to Allah exhibited at least some problematic implications. Amanah mediated Identity linkages with some measures of religious and psychological adjustment, but also suppressed Identity relationships with greater self-knowledge and lower anxiety...
August 17, 2018: Journal of Religion and Health
https://www.readbyqxmd.com/read/30120554/necrotizing-fasciitis-of-the-head-and-neck-our-experience-with-vacuum-assisted-closure-therapy
#4
Mustafa Koray Balcı, Ejder Ciğer, Seçil Arslanoğlu, Akif İşlek
OBJECTIVES: To present the outcomes of our case series of head and neck necrotizing fasciitis (HNNF) in which vacuum-assisted closure (VAC) is used in most of the cases in the treatment. METHODS: Case series in a tertiary referral center. RESULTS: Eleven patients were treated for HNNF between January 2008 and January 2017. Patients were two females and nine males, the mean age was 57.1. Oral cavity and tracheotomy/tracheostomy sites were the main aetiological foci of the infection...
August 17, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/30119153/efficacy-and-safety-of-lenalidomide-and-dexamethasone-in-patients-with-relapsed-refractory-multiple-myeloma-a-real-life-experience
#5
Nur Soyer, Püsem Patır, Ayşe Uysal, Mustafa Duran, Hatice Demet Ünal, Raika Durusoy, Murat Tombuloğlu, Fahri Şahin, Mahmut Töbü, Filiz Vural, Güray Saydam
Background/aim: In Turkey, lenalidomide plus dexamethasone (RD) has been used to treat relapsed/refractory multiple myeloma (RRMM) since 2010. This retrospective, single-center study evaluated the efficacy and tolerability of RD in patients with RRMM between October 2010 and June 2016. Materials and methods: Patients’ records were reviewed, and overall (OS) and progression-free survival (PFS) were assessed. Results: One hundred and twenty patients (71 males; 59...
August 16, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/30119146/relationship-of-serum-hla-b-alleles-and-tnf-%C3%AE-with-rheumatic-heart-disease
#6
Azmi Eyiol, Çağrı Yayla, Serkan Ünlü, Abdurrahman Tufan, Mustafa Cemri, Rıdvan Yalçın, Bülent Boyacı
Background/aim: Acute rheumatic fever and rheumatic heart disease are major causes of morbidity and mortality in developing countries. Genetic studies have determined that the immune response in rheumatic heart disease is genetically controlled and that there is a close relationship between the gene of concern and the class II human leukocyte antigen (HLA) gene. The aim of this study was to evaluate the relationship of serum HLA-B alleles and tumor necrosis factor alpha (TNF-α) with rheumatic heart disease...
August 16, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/30118983/novel-thymol-bearing-oxypropanolamine-derivatives-as-potent-some-metabolic-enzyme-inhibitors-their-antidiabetic-anticholinergic-and-antibacterial-potentials
#7
Mustafa Zengin, Hayriye Genc, Parham Taslimi, Ali Kestane, Ertugrul Guclu, Aziz Ogutlu, Oguz Karabay, İlhami Gulçin
A series of classical and newly synthesized thymol bearing oxypropanolamine compounds were synthesized and characterized. Their in vitro antibacterial activity on A. baumannii, P. aeruginosa, E. coli and S. aureus strains were investigated with agar well diffusion method. The results were compared with commercially available drug active compounds. As well as 3a, 3b and 3c have the most significant antibacterial effect among all the tested compounds; approximately all of them have more antibacterial activity than the reference drugs...
August 7, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/30118962/a-giant-pulmonary-cyst-hydatid-imitating-plevral-effusion
#8
Tuba Apaydın, Mustafa Deniz
INTRODUCTION: Cystic echinococcosis is an endemic disease in east Turkey. Echinococcosis granulosus is reported as the most common agent of cystic echinoccocus. Hydatid cysts are generally involved in lung and liver. PRESENTATION OF CASE: 37 year old female admitted to our clinic with cough and expectoration of watery material progressing within 3 months. Thorax CT demonstrated a 110*100 mm well defined cavitary lesion in the right lower lobe of the lung. The patient was treated with cystotomy & capitonnage and postoperative albendazole treatment successfully...
August 9, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/30118755/genetics-of-stroke-recovery-bdnf-val66met-polymorphism-in-stroke-recovery-and-its-interaction-with-aging
#9
REVIEW
Mustafa Balkaya, Sunghee Cho
Stroke leads to long term sensory, motor and cognitive impairments. Most patients experience some degree of spontaneous recovery which is mostly incomplete and varying greatly among individuals. The variation in recovery outcomes has been attributed to numerous factors including lesion size, corticospinal tract integrity, age, gender and race. It is well accepted that genetics play a crucial role in stroke incidence and accumulating evidence suggests that it is also a significant determinant in recovery. Among the number of genes and variations implicated in stroke recovery the val66met single nucleotide polymorphism (SNP) in the BDNF gene influences post-stroke plasticity in the most significant ways...
August 14, 2018: Neurobiology of Disease
https://www.readbyqxmd.com/read/30117237/circulating-orexin-changes-during-withdrawal-are-associated-with-nicotine-craving-and-risk-for-smoking-relapse
#10
Mustafa al'Absi, Andrine Lemieux, James S Hodges, Sharon Allen
We examined the extent to which orexin measured during smoking and the early phase of abstinence was related to craving, withdrawal, stress hormones, and risk for smoking relapse in men and women. Considering its role in modulating nicotine-related reward, we predicted that a reduction in circulating orexin during withdrawal would be associated with increased craving and risk for smoking relapse. Two hundred and eighty five participants provided biological samples and self-report information to identify predictors of smoking relapse...
August 16, 2018: Addiction Biology
https://www.readbyqxmd.com/read/30117128/3d-echocardiographic-imaging-of-an-extremely-rare-rotation-anomaly-of-the-heart
#11
Kumral Cagli, Zehra Golbasi, Mustafa Ozdemir
No abstract text is available yet for this article.
August 16, 2018: Journal of Echocardiography
https://www.readbyqxmd.com/read/30117036/tenecteplase-versus-alteplase-for-management-of-acute-ischemic-stroke-a-pairwise-and-network-meta-analysis-of-randomized-clinical-trials
#12
Babikir Kheiri, Mohammed Osman, Ahmed Abdalla, Tarek Haykal, Sahar Ahmed, Mustafa Hassan, Ghassan Bachuwa, Mohammed Al Qasmi, Deepak L Bhatt
Tenecteplase is a genetically mutated variant of alteplase with superior pharmacodynamic and pharmacokinetic properties. However, its efficacy and safety in acute ischemic strokes are limited. Hence, we conducted a study to evaluate the efficacy and safety of tenecteplase compared with alteplase in acute ischemic stroke. Electronic databases were searched for randomized clinical trials (RCTs) comparing tenecteplase with alteplase in acute ischemic stroke patients eligible for thrombolysis. We evaluated various efficacy and safety outcomes using random-effects models for both pairwise and Bayesian network meta-analyses along with meta-regression analyses...
August 16, 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/30116997/adjuvant-pharmacotherapies-to-insulin-for-the-treatment-of-type-1-diabetes
#13
REVIEW
Mustafa Tosur, Maria J Redondo, Sarah K Lyons
PURPOSE OF REVIEW: Insulin therapy alone fails to achieve target glycemic control in the majority of individuals with type 1 diabetes (T1D), motivating the investigation of additive medications. This review focuses on the recent findings on the use of adjunctive pharmacotherapy in T1D. RECENT FINDINGS: Metformin and glucagon-like peptide-1 receptor agonists have been associated with weight reduction and decrease in daily insulin requirements without sustainable improvement in glycemic control...
August 17, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/30116938/challenging-the-conventional-treatment-of-colon-cancer-by-sentinel-lymph-node-mapping-and-its-role-of-detecting-micrometastases-for-adjuvant-chemotherapy
#14
REVIEW
Sukamal Saha, Mohamed Elgamal, Meghan Cherry, Robin Buttar, Swetha Pentapati, Suresh Mukkamala, Kiran Devisetty, Sunil Kaushal, Mustafa Alnounou, Trevor Singh, Sandeep Grewal, David Eilender, Madan Arora, David Wiese
All colon cancer patients with lymph node (LN) positive disease are treated with chemotherapy. Patients with node negative disease are usually cured by surgery alone. Yet about 20% of patients develop recurrence within 5 years despite node negative status. This may often be the result of missed micrometastases by conventional examination. Sentinel lymph node (SLN) mapping was developed to find those nodes detected by blue dye which was ultrastaged to detect micrometastases. Consecutive patients, underwent SLN mapping with the blue dye with success rate of 99...
August 16, 2018: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/30116741/the-all-cause-mortality-and-a-screening-tool-to-determine-high-risk-patients-among-prevalent-type-2-diabetes-mellitus-patients
#15
Mohamad Adam Bujang, Pei Xuan Kuan, Xun Ting Tiong, Fatin Ellisya Saperi, Mastura Ismail, Feisul Idzwan Mustafa, Abd Muneer Abd Hamid
Aims: This study aims to determine the all-cause mortality and the associated risk factors for all-cause mortality among the prevalent type 2 diabetes mellitus (T2DM) patients within five years' period and to develop a screening tool to determine high-risk patients. Methods: This is a cohort study of T2DM patients in the national diabetes registry, Malaysia. Patients' particulars were derived from the database between 1st January 2009 and 31st December 2009. Their records were matched with the national death record at the end of year 2013 to determine the status after five years...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/30116511/large-de-novo-ascending-aortic-thrombus-successfully-treated-with-anticoagulation
#16
Mustafa Houmsse, Asia McDavid, Ahmet Kilic
An ascending aortic thrombus is a rare source for embolic transient ischemic attack (TIA) or stroke without an associated aortic pathology. Here we describe a case of a patient who presented with generalized symptoms of headache and fatigue who, on subsequent work-up , was found to have an ascending aortic thrombus with no obvious associated aortic pathology, and was successfully treated with apixaban, a newer direct oral anticoagulant.
2018: Journal of Cardiovascular and Thoracic Research
https://www.readbyqxmd.com/read/30116441/low-vitamin-d-deficiency-associated-with-thyroid-disease-among-type-2-diabetic-mellitus-patients
#17
Abdulbari Bener, Yasar Ozdenkaya, Abdulla O A A Al-Hamaq, Cem Cahit Barisik, Mustafa Ozturk
Background: The aim of this study was to investigate the relationship between vitamin D deficiency and thyroid diseases among type 2 diabetes mellitus (T2DM) patients. Methods: This was a cohort case and control study, 546 T2DM patients and 546 control study participants were enrolled, aged between 25 and 65 years. The subjects were also investigated for fasting blood glucose levels (FBG), post prandial glucose (PPG,) glycosylated hemoglobin (HbA1c), thyroid stimulating hormone (TSH), T3, T4, and presence of other comorbid conditions...
September 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/30116131/distribution-of-childhood-skin-diseases-according-to-age-and-gender-a-single-institution-experience
#18
Sinan Özçelik, İbrahim Kulaç, Mustafa Yazıcı, Esra Öcal
Aim: Studies on pediatric skin diseases in Turkey are not yet sufficient. It was aimed to characterize the prevalence of skin diseases, age and gender distribution in children living in the Erzincan region. Material and Methods: 10,115 children aged 0-16 years who reached to our outpatient clinic between 01.11.2014 and 30.11.2016 were included in the study. The frequency, age and gender distribution of the skin diseases were examined. The cases were divided into 4 groups; infantile period (0-2 years), preschool period (3-5 years), school period (6-11 years) and adolescence period (12-16 years)...
June 2018: Türk Pediatri Arşivi
https://www.readbyqxmd.com/read/30115011/the-effect-of-patient-positions-on-perfusion-index
#19
Hakan Tapar, Serkan Karaman, Serkan Dogru, Tugba Karaman, Aynur Sahin, Gulsen Genc Tapar, Fatih Altiparmak, Mustafa Suren
BACKGROUND: The optimal position for surgery is one in which the patient is provided the best possible surgical intervention and put at minimum risk. Different surgical positions may cause changes in tissue perfusion. This study investigates the relationship between surgical patient positions and perfusion index. METHODS: A sample of 61 healthy individuals with no peripheral circulatory disorders, chronic diseases, or anemia was included in this study. Participants held six different positions: supine, prone, 45-degree sitting-supine, 45-degree supine with legs lifted, Trendelenburg (45-degrees head down), and reverse Trendelenburg (45-degrees head up)...
August 17, 2018: BMC Anesthesiology
https://www.readbyqxmd.com/read/30114942/serum-electrolyte-levels-and-ventricular-arrhythmia
#20
Yasin Ozen, Mustafa Bilal Ozbay, Ahmet Goktuğ Ertem, Çağri Yayla
No abstract text is available yet for this article.
August 16, 2018: Angiology
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