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Pavan M V Raja, Gibran L Esquenazi, Kourtney D Wright, Cathren E Gowenlock, Bruce E Brinson, Shirin Alexander, Daniel R Jones, Varun Shenoy Gangoli, Andrew R Barron
The electromigration behaviour of raw and acid purified single walled carbon nanotubes (SWCNTs) in dilute aqueous systems (0.0034 mg mL-1), in the absence of surfactant, with the addition of either 0.85 M acetic acid or 0.1 M CuSO4, was evaluated using a 2-inch copper cathode and either a 2-inch copper or 0.5-inch platinum anode. The results showed that the electromigration of raw SWCNTs (with a high catalyst residue) in the presence of CuSO4 resulted in the formation of a Cu-SWCNT composite material at the cathode...
October 16, 2018: Nanoscale
Sima T Bhatt, Jeffrey J Bednarski, Julia Berg, Kathryn Trinkaus, Lisa Murray, Robert Hayashi, Ginny Schulz, Monica Hente, Michael Grimley, Ka Wah Chan, Naynesh Kamani, David Jacobsohn, Michael Nieder, Gregory Hale, Lolie Yu, Roberta Adams, Jignesh Dalal, Michael A Pulsipher, Paul Haut, Sonali Chaudhury, Jeffrey Davis, Jennifer Jaroscak, Martin Andreansky, Jennifer Willert, Shalini Shenoy
Hematopoietic stem cell transplantation (HSCT) is a therapeutic option for many nonmalignant disorders (NMD) and is curative or prevents disease progression. Reduced intensity conditioning (RIC) in HSCT for NMD may reduce regimen-related acute toxicities and late complications. Myeloablation is often replaced by immune suppression in RIC regimens to support donor engraftment. The pace of immune reconstitution following immune suppression by RIC regimens is influenced by agents used, donor source, and graft-versus-host disease (GVHD) prophylaxis/treatment...
October 12, 2018: Biology of Blood and Marrow Transplantation
C M Nasheeda, Prijo Philip, Rathika Damodara Shenoy, Sukanya Shetty
Even in the era of expanded newborn screening, utility of cord blood thyroid stimulating hormone (cTSH) for diagnosis of congenital hypothyroidism (CH) cannot be marginalised. This study was to assess the diagnostic utility of cTSH > 20 μIU/L for screening CH. Generation of new cTSH value was the main outcome measure, to increase specificity. Designed as a cross-sectional analytic study in the neonatal unit of teaching hospital, 1200 term neonates with birth weight ≥2500 g, with no perinatal complications were included...
October 2018: Indian Journal of Clinical Biochemistry: IJCB
Shalvika Gupta, Vijetha Shenoy Belle, Ramya Kumbarakeri Rajashekhar, Sushma Jogi, Rv Krishnananda Prabhu
Cholinesterases belongs to class hydrolases. There are two types acetylcholinesterase and butyryl cholinesterase. Acetylcholinesterase present in nerve endings and also in the RBC membrane. It helps to maintain the shape and size of RBCs. Any change in shape and size of RBCs may affect the activity of Acetylcholinesterase. Thus this study aimed to estimate RBCs Acetylcholinesterase enzyme activity in various types of anemias and correlate the RBCs Acetylcholinesterase enzyme activity with various hematological indices such as Erythrocyte Sedimentation Rate (ESR), Mean Corpuscular Hemoglobin (MCH), Mean Corpuscular Hemoglobin Concentration (MCHC), Mean Corpuscular Volume (MCV), Red cell Distribution Width (RDW) etc...
October 2018: Indian Journal of Clinical Biochemistry: IJCB
S Shruthi, K Bhasker Shenoy
Chemotherapeutic drugs are used for the treatment of cancer. However, the use of these drugs is limited due to their side effects on normal cells. One of the measures to detect chemoprotection of plant extracts is to evaluate their anticlastogenic effects. In this study, we report the anticlastogenic effect of gallic acid (GA) against cisplatin (Csp), a chemotherapeutic drug, in Swiss albino mice. Three different doses of GA (100, 200 and 400 mg per kg bw) were administered orally to the experimental animals in 0...
September 1, 2018: Toxicology Research
Fahad Mohammad, Aniruddh Shenoy
No abstract text is available yet for this article.
2018: Advances in Medical Education and Practice
David S Sarkany, Anuradha S Shenoy-Bhangle, Tara M Catanzano, Tabitha A Fineberg, Ronald L Eisenberg, Priscilla J Slanetz
Running a successful radiology residency program requires departments to navigate the evolving educational landscape at the departmental, institutional, and national levels. To attract the best applicants, departments must invest time and money to support the leadership of the program and its faculty to provide innovative educational opportunities in a positive learning environment while simultaneously complying with all of the requirements of the Accreditation Council for Graduate Medical Education. The key administrative requirements of a successful radiology residency program are described and can be grouped into (a) essential administrative components, (b) the clinical learning environment review and self-study process, and (c) resident recruitment...
October 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
Liyana Ahmad, Bayarchimeg Mashbat, Corwin Leung, Charlotte Brookes, Samar Hamad, Sina Krokowski, Avinash R Shenoy, Lazaro Lorenzo, Michael Levin, Peter O'Hare, Shen-Ying Zhang, Jean-Laurent Casanova, Serge Mostowy, Vanessa Sancho-Shimizu
No abstract text is available yet for this article.
October 5, 2018: Journal of Allergy and Clinical Immunology
Nimi N, Ariya Saraswathy, Shaiju S Nazeer, Nimmi Francis, Sachin J Shenoy, Ramapurath S Jayasree
Though nanoparticles are being used for several biomedical applications, the safety of the same is still a concern. It is very routine procedure to check the preliminary safety aspects of the particles intended for in vivo applications. The major tests include how the material reacts to a normal cell, how it behaves with the blood cells and also whether any lysis take place in the presence of these materials. Here we present these test data of two novel nanomaterials designed for its use as contrast agent for magnetic resonance imaging and a multimodal contrast agent for targeted liver imaging...
October 2018: Data in Brief
Sanjit Kumar Agrawal, Sachin Suresh Shenoy, Nikhil Nalawade, Soumtira Shankar Datta, Soumendranath Roy, Sanjoy Chatterjee, Indu Arun, Rosina Ahmed
Quality Indicators for Sentinel Lymph Node Biopsy in Breast Cancer: Applicability and Clinical Relevance in a Non-screened Population: sentinel lymph node biopsy (SLNB) has replaced axillary lymph node dissection (ALND) as standard of care for management of early breast cancer. This study assessed our SLNB program against 11 published quality indicators (QIs). All breast cancer patients who underwent SLNB in our centre from June 2013-Dec 2015 were included. Clinical, pathological and follow-up data were extracted from the institutional REDCap data system...
September 2018: Indian Journal of Surgical Oncology
Changliang Chen, Anitha K Shenoy, Ravi Padia, Dongdong Fang, Qing Jing, Ping Yang, Shi-Bing Su, Shuang Huang
BACKGROUND: Licorice is an herb extensively used for both culinary and medicinal purposes. Various constituents of licorice have been shown to exhibit anti-tumorigenic effect in diverse cancer types. However, majority of these studies focus on the aspect of their growth-suppressive role. In this study, we systematically analyzed known licorice's constituents on the goal of identifying component(s) that can effectively suppress both cell migration and growth. METHODS: Effect of licorice's constituents on cell growth was evaluated by MTT assay while cell migration was assessed by both wound-healing and Transwell assays...
October 3, 2018: Journal of Experimental & Clinical Cancer Research: CR
Sujith Raj Salian, Guruprasad Nayak, Sandhya Kumari, Sandesh Patel, Shruthi Gowda, Yashaswini Shenoy, Sinoy Sugunan, Rajanikant G K, Renuka Suresh Managuli, Srinivas Mutalik, Vandana Dahiya, Samanwita Pal, Satish Kumar Adiga, Guruprasad Kalthur
PURPOSE: Motility of spermatozoa helps not only in planning the type of infertility treatment but also directly reflects the success rate in assisted reproductive technology (ART). Previously, biotin, a water-soluble vitamin, has been shown to increase the motility and longevity of cryopreserved human spermatozoa. The present study was designed to understand the molecular basis of the beneficial effects of presence of biotin in sperm wash medium on early embryo development. METHODS: The effect biotin supplementation to sperm wash medium on the sperm parameters were assessed in swim-up fraction of normozoospermic and asthenozoospermic ejaculates collected from infertile men...
October 4, 2018: Journal of Assisted Reproduction and Genetics
Amanpreet Kaur, Brett L Ecker, Stephen M Douglass, Curtis H Kugel, Marie R Webster, Filipe V Almeida, Rajasekharan Somasundaram, James Hayden, Ehsan Ban, Hossein Ahmadzadeh, Janusz Franco-Barraza, Neelima Shah, Ian A Mellis, Frederick Keeney, Andrew Kossenkov, Hsin-Yao Tang, Xiangfan Yin, Qin Liu, Xiaowei Xu, Mitchell Fane, Patricia Brafford, Meenhard Herlyn, David W Speicher, Jennifer A Wargo, Michael T Tetzlaff, Lauren E Haydu, Arjun Raj, Vivek Shenoy, Edna Cukierman, Ashani T Weeraratna
Physical changes in skin are among the most visible signs of aging. We found that young dermal fibroblasts secrete high levels of extracellular matrix (ECM) constituents, including proteoglycans, glycoproteins and cartilage-linking proteins. The most abundantly secreted was HAPLN1, a hyaluronic and proteoglycan link protein. HAPLN1 was lost in aged fibroblasts, resulting in a more aligned ECM that promoted metastasis of melanoma cells. Reconstituting HAPLN1 inhibited metastasis in an aged microenvironment, in 3D skin reconstruction models, and in vivo...
October 2, 2018: Cancer Discovery
Rathika Damodara Shenoy, Vijaya Shenoy, Vikram Shetty
This case series of three children reports clinical features and chromosomal abnormalities seen in a craniofacial clinic. All presented with orofacial cleft, developmental or intellectual disability, and dysmorphism. Emanuel syndrome or supernumerary der (22)t(11; 22), the prototype of complex small supernumerary marker disorders, was seen in one child. Duplication 4q27q35.2 with concomitant deletion 21q22.2q22.3 and duplication 12p13.33p13.32 with concomitant deletion 18q22.3q23 seen in the remaining two children are not reported in literature...
2018: Case Reports in Genetics
Karthik Damodaran, Saradha Venkatachalapathy, Farid Alisafaei, A V Radhakrishnan, Doorgesh Sharma Jokhun, Vivek B Shenoy, G V Shivashankar
Fibroblasts exhibit heterogeneous cell geometries in tissues and integrate both mechanical and biochemical signals in their local microenvironment to regulate genomic programs via chromatin remodelling. While in connective tissues fibroblasts experience tensile and compressive forces (CFs), the role of compressive forces in regulating cell behaviour and in particular, the impact of cell geometry in modulating transcriptional response to such extrinsic mechanical forces is unclear. Here, we show that CF on geometrically well-defined mouse fibroblast cells reduces actomyosin contractility and shuttles Histone Deacetylase 3 (HDAC3), into the nucleus...
September 26, 2018: Molecular Biology of the Cell
Louis M Luttrell, Jialu Wang, Bianca Plouffe, Jeffrey S Smith, Lama Yamani, Suneet Kaur, Pierre-Yves Jean-Charles, Christophe Gauthier, Mi-Hye Lee, Biswaranjan Pani, Jihee Kim, Seungkirl Ahn, Sudarshan Rajagopal, Eric Reiter, Michel Bouvier, Sudha K Shenoy, Stéphane A Laporte, Howard A Rockman, Robert J Lefkowitz
G protein-coupled receptors (GPCRs) use diverse mechanisms to regulate the mitogen-activated protein kinases ERK1/2. β-Arrestins (βArr1/2) are ubiquitous inhibitors of G protein signaling, promoting GPCR desensitization and internalization and serving as scaffolds for ERK1/2 activation. Studies using CRISPR/Cas9 to delete βArr1/2 and G proteins have cast doubt on the role of β-arrestins in activating specific pools of ERK1/2. We compared the effects of siRNA-mediated knockdown of βArr1/2 and reconstitution with βArr1/2 in three different parental and CRISPR-derived βArr1/2 knockout HEK293 cell pairs to assess the effect of βArr1/2 deletion on ERK1/2 activation by four Gs -coupled GPCRs...
September 25, 2018: Science Signaling
Kiran Chawla, Elena Martinez, Ajay Kumar, Vishnu Prasad Shenoy, Vitali Sintchenko
OBJECTIVES: The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) Mycobacterium tuberculosis strains has opened up new challenges for tuberculosis (TB) control in India. This study examined molecular markers of resistance to bedaquiline, a new antituberculous drug with the potential to dramatically improve MDR-TB treatment outcomes and to reduce mortality. METHODS: A clinical M. tuberculosis isolate with a MDR-TB profile was subjected to whole-genome sequencing using an Illumina NextSeq500 platform, followed by genome-wide sequence analysis...
September 21, 2018: Journal of Global Antimicrobial Resistance
K Yogeswara Chari, Picheswara Rao Polu, Rekha R Shenoy
Background: Cancer is one of the most important public health burdens in developed and developing countries. Colon cancer (CC) is the sixth most common cause of death in India and third most important cause in developed countries. For treating cancer, several synthetic agents are available but they cause side effects. Therefore, there is a need to investigate plant derived anticancer agents with lesser side effects. In this direction, we have made an attempt to unravel the potential of pumpkin seed extract for treating colon cancer...
2018: Journal of Toxicology
Chethan Pandarinath, Daniel J O'Shea, Jasmine Collins, Rafal Jozefowicz, Sergey D Stavisky, Jonathan C Kao, Eric M Trautmann, Matthew T Kaufman, Stephen I Ryu, Leigh R Hochberg, Jaimie M Henderson, Krishna V Shenoy, L F Abbott, David Sussillo
Neuroscience is experiencing a revolution in which simultaneous recording of thousands of neurons is revealing population dynamics that are not apparent from single-neuron responses. This structure is typically extracted from data averaged across many trials, but deeper understanding requires studying phenomena detected in single trials, which is challenging due to incomplete sampling of the neural population, trial-to-trial variability, and fluctuations in action potential timing. We introduce latent factor analysis via dynamical systems, a deep learning method to infer latent dynamics from single-trial neural spiking data...
October 2018: Nature Methods
Anukul T Shenoy, Sarah M Beno, Terry Brissac, Jeremiah W Bell, Lea Novak, Carlos J Orihuela
Streptococcus pneumoniae is an opportunistic Gram-positive pathogen that can cause invasive disease. Recent studies have shown that S. pneumoniae is able to invade the myocardium and kill cardiomyocytes, with one-in-five adults hospitalized for pneumococcal pneumonia having a pneumonia-associated adverse cardiac event. Furthermore, clinical reports have shown up to a 10-year increased risk of adverse cardiac events in patients formerly hospitalized for pneumococcal bacteremia. In this study, we investigated the ability of nine S...
2018: PloS One
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