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Bart L Dolmatch, John C Gurley, Kevin M Baskin, Boris Nikolic, Jeffrey H Lawson, Surendra Shenoy, Theodore F Saad, Ingemar Davidson, Mark O Baerlocher, Emil I Cohen, Sean R Dariushnia, Salomão Faintuch, Bertrand Janne d'Othee, Thomas B Kinney, Mehran Midia, James Clifton
No abstract text is available yet for this article.
August 13, 2018: Journal of Vascular Access
Rukshana Shroff, Aysun Bayazit, Constantinos J Stefanidis, Varvara Askiti, Karolis Azukaitis, Nur Canpolat, Ayse Agbas, Ali Anarat, Bilal Aoun, Sevcan Bakkaloglu, Devina Bhowruth, Dagmara Borzych-Dużałka, Ipek Kaplan Bulut, Rainer Büscher, Claire Dempster, Ali Duzova, Sandra Habbig, Wesley Hayes, Shivram Hegde, Saoussen Krid, Christoph Licht, Mieczyslaw Litwin, Mark Mayes, Sevgi Mir, Rose Nemec, Lukasz Obrycki, Fabio Paglialonga, Stefano Picca, Bruno Ranchin, Charlotte Samaille, Mohan Shenoy, Manish Sinha, Colette Smith, Brankica Spasojevic, Enrico Vidal, Karel Vondrák, Alev Yilmaz, Ariane Zaloszyc, Michel Fischbach, Franz Schaefer, Claus Peter Schmitt
BACKGROUND: Cardiovascular disease is prevalent in children on dialysis and accounts for almost 30% of all deaths. Randomised trials in adults suggest that haemodiafiltration (HDF) with high convection volumes is associated with reduced cardiovascular mortality compared to high-flux haemodialysis (HD); however paediatric data are scarce. We designed the haemodiafiltration, heart and height (3H) study to test the hypothesis that children on HDF have an improved cardiovascular risk profile, growth and nutritional status and quality of life, compared to those on conventional HD...
August 10, 2018: BMC Nephrology
Abdullah Al-Mujaini, Kashinatha Shenoy, Upender Wali
Purpose: To describe a triad of fibrous histiocytoma, Systemic Lupus Erythematosus and Sero-positive Sjögren's Syndrome. Observations: This case was diagnosed first as bilateral fibrous histiocytoma of cheeks, which on further investigations proved to be a triad of Systemic Lupus Erythematosus, Fibrous histiocytoma and Sero-positive Sjögren's Syndrome. Conclusions and importance: Association between fibrous histiocytoma, Systemic Lupus Erythematosus and Sero-positive Sjögren's Syndrome has been known before, but fibrous histiocytoma as first presentation in the triad has not been reported...
September 2018: American Journal of Ophthalmology Case Reports
Sushruta S Hakkimane, Vishnu Prasad Shenoy, Santosh L Gaonkar, Indira Bairy, Bharath Raja Guru
Introduction: Tuberculosis (TB) is the single largest infectious disease which requires a prolonged treatment regime with multiple drugs. The present treatment for TB includes frequent administration of a combination of four drugs for a duration of 6 months. This leads to patient's noncompliance, in addition to developing drug-resistant strains which makes treatment more difficult. The formulation of drugs with biodegradable polymeric nanoparticles (NPs) promises to overcome this problem...
2018: International Journal of Nanomedicine
Anusha Vakiti, Ravi Pilla, Muhamad Alhaj Moustafa, Jacinth J Joseph, Aarthi G Shenoy
Ifosfamide, an alkylating agent used in cancer treatments, can cause neurotoxicity. The clinical presentation can range from mild symptoms such as acute confusion to non-convulsive seizures, severe irreversible coma, and death. The benefit of methylene blue use in treating ifosfamide-induced metabolic encephalopathy is not well established. In this article, we present 2 cases of ifosfamide-induced metabolic encephalopathy responsive to methylene blue treatment.
January 2018: Journal of Investigative Medicine High Impact Case Reports
Bhagyashree Jaipuria, Deviprasad Dosemane, Panduranga M Kamath, Suja S Sreedharan, Vijendra S Shenoy
Introduction: Computed tomography (CT) imaging is the choice of investigation for evaluation of extent of tumor under the mucosa, locally and regionally. This study was undertaken to assess the accuracy of preoperative CT imaging in the staging of carcinoma of the larynx and hypopharynx. Materials and Methods: In this retrospective study, all cases who were clinically (c) staged T3-T4 and who underwent surgery were evaluated. The sensitivity (Sn), specificity (Sp), positive predictive value (PPV), negative predictive value (NPV), and accuracy (Ac) of a preoperative CT scan to detect cartilaginous penetration and spread outside the larynx was evaluated...
July 2018: Iranian Journal of Otorhinolaryngology
Pramod Theetha Kariyanna, Apoorva Jayarangaiah, Ronald Pedalino, Sudhanva Hegde, Jonathan D Marmur, Aarti Shenoy, Michael Ashamalla, Justina Ray, Samy I McFarlane
Community acquired methicillin resistant Staphylococcus aureus (CA-MRSA) infection is a matter of public health concern. The incidence of community acquired Staphylococcus aureus (CA-MRSA) is rising. To date only 12 cases of CA-MRSA pericarditis and seven cases of esophageal cancer related purulent pericarditis have been reported. We here present a 54 year old woman who presented with cardiac tamponade that was noted to be purulent and in whom esophagopericardial fistula secondary to squamous cell esophageal cancer was discovered subsequently...
2018: American journal of medical case reports
Rahul Priyadarshi, Hari P S Arremsetty, Akhilesh K Singh, Durga Khandekar, Kandasamy Ulaganathan, Vinay Shenoy, Pallavi Sinha, Vikas K Singh
The degree of heterosis in different hybrid rice varieties is reported to be at the highest in indica / japonica cross combination, however, there is a problem of sterility and semi-sterility in such inter sub specific hybrids. To overcome this problem, it is essential to develop parental lines having wide compatibility ( S5 n ) gene. In this study, a functional marker S5-InDel was used for marker-assisted backcrossing (MABB) to introgress S5 n gene from Dular into the genetic background of a widely grown recurrent parent IR 58025B, a maintainer line of wild-abortive (WA) cytoplasmic male sterile line, IR 58025A...
2018: Frontiers in Plant Science
Niraj Shenoy, Mythri Mudireddy, Rangit Vallapureddy, Nelson Leung, Lance Pagliaro, Thomas Witzig, Fang-Shu Ou, Tamas Ordog, John Cheville, Mrinal Patnaik, R Houston Thompson, Ayalew Tefferi, Kebede Begna
BACKGROUND: Renal cell carcinoma (RCC) and certain myeloid malignancies are both characterized by widespread aberrant DNA hypermethylation. After clinical observations of patients with a personal history of both malignancies, we sought to explore a potential association, and to describe the clinical characteristics of these patients. PATIENTS AND METHODS: Mayo Clinic's 'Advanced Cohort Explorer' database was used to identify patients with a history of both malignancies...
June 28, 2018: Clinical Genitourinary Cancer
Shrikala Baliga, Christina Murphy, Leesha Sharon, Suchitra Shenoy, Dhanashree Biranthabail, Helena Weltman, Steve Miller, Ranjan Ramasamy, Jyotsna Shah
PURPOSE: Mycobacterium tuberculosis in sputum is mainly detected in resource-limited tuberculosis-endemic countries by acid-fast bacilli (AFB) staining and identifying sputum-derived cultures. PCR techniques are practical only in well-resourced laboratories. We investigated the application of a rapid, simple and inexpensive fluorescence in situ hybridization (FISH) assay to identify and differentiate M. tuberculosis complex (MTBC) from non-tuberculous mycobacteria (NTM) in sputa. METHODS: The Mycobacterium/Nocardia Genus (MN Genus)-MTBC FISH assay utilized two different DNA probes labelled with different fluorescent molecules that hybridize respectively with 16S rRNA of the genus Mycobacterium and 23S rRNA of MTBC...
July 23, 2018: International Journal of Infectious Diseases: IJID
Yongkang Zou, Zhi Qi, Weilong Guo, Liuzhen Zhang, Marcus Ruscetti, Tanu Shenoy, Ningshu Liu, Hong Wu
Targeting the PI3K pathway is a promising strategy for treating prostate cancers with PTEN-loss. However, current anti-PI3K therapies fail to show long-lasting in vivo effects. We find that not only the PI3Kα- and PI3kβ-isoforms, but also PI3Kδ are associated with the epithelial-mesenchymal transition (EMT), a critical process distinguishing indolent from aggressive prostate cancer. This suggests that co-targeting PI3Kα/β/δ could pre-empt the rebound activation of the parallel pathways induced by α- or β-isoform-selective inhibitor and prevent EMT...
July 25, 2018: Molecular Cancer Therapeutics
Chandrashekar Byalekere Shivanna, Chaithra Shenoy, R Arti Priya
Background: Alopecia areata (AA) is a chronic autoimmune disorder characterized by patchy loss of hair from scalp, beard, eyebrows, or rarely even body hair. Rarely, the disease can be widespread and severe leading to loss of entire scalp and body hair causing apprehension and psychological stress in patients. Management of such cases is equally difficult with the available options of topical and systemic immunosuppressant. Tofacitinib, JAK3 inhibitor, is emerging as a promising drug for the management of severe and resistant cases of AA/totalis/universalis...
May 2018: International Journal of Trichology
Shaiju S Nazeer, Ariya Saraswathy, Sachin J Shenoy, Ramapurath S Jayasree
The study utilizes autofluorescence spectroscopy (AFS) along with multivariate spectral analysis for differentiating various stages of hepatic fibrosis. AFS has recently emerged as an efficient tool for evaluating the variations in different endogenous flurophores. In this study, the potential of AFS for differentiating the stages of liver fibrosis is assessed and compared with the results of enzyme evaluation, histopathology and the most advanced diagnostic tool, MRI. Using a fiber optic probe, the emission profile of the flurophores such as flavin adenine dinucleotide (FAD), lipofuscin-like lipopigments (lipopigments), porphyrins and the variation in the total hemoglobin concentration are evaluated in vivo on liver fibrosis induced animal models adopting a minimally invasive technique...
July 20, 2018: Scientific Reports
Benjamin R Freedman, Ashley B Rodriguez, Ryan J Leiphart, Joseph B Newton, Ehsan Ban, Joseph J Sarver, Robert L Mauck, Vivek B Shenoy, Louis J Soslowsky
The extracellular matrix (ECM) is the primary biomechanical environment that interacts with tendon cells (tenocytes). Stresses applied via muscle contraction during skeletal movement transfer across structural hierarchies to the tenocyte nucleus in native uninjured tendons. Alterations to ECM structural and mechanical properties due to mechanical loading and tissue healing may affect this multiscale strain transfer and stress transmission through the ECM. This study explores the interface between dynamic loading and tendon healing across multiple length scales using living tendon explants...
July 18, 2018: Scientific Reports
Shiran Shetty, Shankar Prasad Nagaraju, Srinivas Shenoy, Ravindra Prabhu Attur, Dharshan Rangaswamy, Indu R Rao, Uday Venkat Mateti, Rajeevalochana Parthasarathy
BACKGROUND: Acute kidney injury (AKI) is a common complication of liver cirrhosis and is associated with poor survival. We studied the clinical profile and predictors of in-hospital mortality in patients with cirrhosis of the liver with AKI. METHODS: This retrospective cohort study examined patients at a tertiary care hospital. AKI staging was done based on the new 2015 Ascites Club Criteria. Patients were grouped into three types of AKI: pre-renal azotemia (PRA), hepatorenal syndrome (HRS), and acute tubular necrosis (ATN)...
May 2018: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
Madeleine D Hunter, Adele Shenoy, Andrew Dwork, Mitchell S V Elkind, Randolph Marshall, Jay P Mohr, Susan Morgello, Jose Gutierrez
OBJECTIVE: To test whether HIV is associated with brain large artery vulnerable intima. DESIGN: Cross-sectional study of autopsied HIV+ cases sex and age-matched to HIV- controls. METHODS: Brain large arteries from 302 autopsied cases (50% HIV+) were evaluated morphometrically for the presence of atherosclerosis, size of necrotic core, and fibrous cap thickness. Intima vulnerability was measured as intima elastolytic score [0-5, based on intimal metalloproteinases (MMP)-2, MMP-3, and MMP-9, and tissue inhibitor for MMP-1 and MMP-2 staining], intima inflammatory score (0-3, based on intimal presence of CD3 and CD68 cells and TNF-α staining), neoangiogenesis (factor VIII staining), and apoptosis (caspase 3 staining)...
July 12, 2018: AIDS
Sally Black, Carina Bradley, Florence Y Lai, Savitha Shenoy, Srini Bandi, David J Allen, Julian W Tang
Comparison of children hospitalized with enterovirus (EV) or human parechovirus (HPeV) detected in their cerebrospinal fluid (CSF) revealed that HPeV infections presented with more persistent fever, irritability and feeding problems, more frequent leukopenia and lymphopenia, and higher admission rates to high dependency or intensive care units. Few HPeV cases were followed-up, further studies on long-term outcomes are needed.
July 11, 2018: Pediatric Infectious Disease Journal
Carl Allen, Rebecca Marsh, Peter Dawson, Catherine M Bollard, Shalini Shenoy, Philip Roehrs, Rabi Hanna, Lauri Burroughs, Leslie Kean, Julie-An Talano, Kirk R Schultz, Sung-Yun Pai, K Scott Baker, Jeffrey R Andolina, Elizabeth O Stenger, James Connelly, Alyssa Ramirez, Christopher Bryant, Mary Eapen, Michael A Pulsipher
Allogeneic hematopoietic cell transplantation (HCT) with myeloablative conditioning for disorders associated with excessive inflammation such as hemophagocytic lymphohistiocytosis (HLH) is associated with early mortality. A multicenter prospective phase 2 trial of reduced intensity conditioning with melphalan, fludarabine and intermediate-timing alemtuzumab was conducted for HLA matched or single HLA-locus mismatched related or unrelated donor HCT in a largely pediatric cohort. Graft-versus-host disease (GVHD) prophylaxis was cyclosporine with methylprednisolone...
July 11, 2018: Blood
K Chawla, A Kumar, V P Shenoy, D S Chauhan, P Sharma
BACKGROUND: There are no published reports on the strain diversity and relative transmission of Mycobacterium tuberculosis isolates circulating in Karnataka State, India. OBJECTIVE: To explore the strain diversity of M. tuberculosis isolates and their relative transmission in south coastal Karnataka using spoligotyping and mycobacterial interspersed repetitive unit-variable number of tandem repeats (MIRU-VNTR) typing. DESIGN: A total of 108 clinical isolates of M...
August 1, 2018: International Journal of Tuberculosis and Lung Disease
Lucy Plumb, Anna Casula, Winnie Magadi, Fiona Braddon, Malcolm Lewis, Stephen D Marks, Mohan Shenoy, Manish D Sinha, Heather Maxwell
No abstract text is available yet for this article.
2018: Nephron
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