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Agustina Schiappacasse, Romina Eugenia Maltaneri, María Eugenia Chamorro, Alcira Beatriz Nesse, Diana Elena Wetzler, Daniela Cecilia Vittori
Many patients under therapy with recombinant human erythropoietin (rhuEPO) show resistance to the treatment, an effect likely associated with the accumulation of tissue factors, especially in renal and cardiovascular diseases. Hyperhomocysteinemia due to high serum levels of homocysteine has been suggested among the risk factors in those pathologies. Its main effect is the N-homocysteinylation of proteins due to the interaction between the highly reactive homocysteine thiolactone (HTL) and lysine residues. The aim of this study was to evaluate the effect of N-homocysteinylation on the erythropoietic and antiapoptotic abilities of EPO, which can be a consequence of structural changes in the modified protein...
August 13, 2018: FEBS Journal
Oliver Lung, Mathew Fisher, Anthony Erickson, Charles Nfon, Aruna Ambagala
Differential diagnosis of diseases that share common clinical signs typically requires the performance of multiple independent diagnostic tests to confirm diagnosis. Diagnostic tests that can detect and discriminate between multiple differential pathogens in a single reaction may expedite, reduce costs and streamline the diagnostic testing workflow. Livestock hemorrhagic diseases like classical swine fever (CSF), African swine fever (ASF), and vesicular diseases such as foot-and-mouth disease (FMD), vesicular stomatitis (VS) and swine vesicular disease (SVD) can have an enormous impact on the livestock industry and economy of countries that were previously free of the diseases...
August 13, 2018: Transboundary and Emerging Diseases
Janine S Cardoso-Rurr, Juliana Patrão de Paiva, Ivan G Paulino-Lima, Tatiana A M de Alencar, Claudia A S Lage, Alvaro C Leitão
Rational use of water is a major challenge for governments and global organizations, with easy and inexpensive interventions being sought by communities that are not supplied with drinking water. In this context, solar disinfection (SODIS) has shown great efficiency for water disinfection. To speed up the process and improve inactivation, we studied the effects of methylene blue (MB) as a photodynamic agent because of its ability to absorb visible light (red wavelength) and generate singlet oxygen as a reactive species, thereby inactivating bacteria and viruses present in water...
August 13, 2018: Photochemistry and Photobiology
Lisa Gross, Dietmar Trenk, Claudius Jacobshagen, Anne Krieg, Meinrad Gawaz, Steffen Massberg, Monika Baylacher, Daniel Aradi, Fabian Stimpfle, Julia Hromek, Anja Vogelgesang, Martin Hadamitzky, Dirk Sibbing, Tobias Geisler
BACKGROUND:  Phenotype-guided de-escalation (PGDE) of P2Y12 -inhibitor treatment with an early switch from prasugrel to clopidogrel was identified as an effective alternative treatment strategy in acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI). The Testing Responsiveness to Platelet Inhibition on Chronic Antiplatelet Treatment for Acute Coronary Syndromes (TROPICAL-ACS) Genotyping Substudy aimed to investigate whether CYP2C19 genotypes correlate with on-treatment platelet reactivity (PR) in ACS patients treated with clopidogrel or prasugrel and thus might be useful for guidance of early de-escalation of anti-platelet treatment...
August 13, 2018: Thrombosis and Haemostasis
Mrinal Kumar Sarma, Mohd Golam Abdul Quadir, Rupam Bhaduri, Sharbani Kaushik, Pranab Goswami
Combined power generation and waste degradation through microbial fuel cell (MFC) technology is emerging as an attractive solution for controlling pollution in water bodies. Cyanobacteria as fuel cell catalysts for such shared energy activities are not well studied even though these possess robust metabolic systems supporting exo-electrogenicity, biodegradation of toxic compounds, and their survival under wide environmental conditions. Herein, a dual chambered (50 ml each) MFC assembled with Synechococcus sp...
July 31, 2018: Biosensors & Bioelectronics
Dengjie Zhong, Xinrong Liao, Yaqi Liu, Nianbing Zhong, Yunlan Xu
It is of significant importance to simultaneously shorten the start-up time and enhance the electricity generation performance for practical application of microbial fuel cell (MFC). In this paper, the polydiallyldimethylammonium chloride (PDDA) modified carbon felt (PDDA-CF) electrode was prepared and used as the anode of PDDA-MFC. The anode significantly enhanced the start-up speed and electricity generation and dye wastewater degradation performances of the PDDA-MFC. The start-up time of PDDA-MFC is only 9 h, which is only 7...
August 1, 2018: Biosensors & Bioelectronics
Yunling Gao, Yong Pan, Yu Chi, Yuanyuan He, Haiyan Chen, Victor N Nemykin
An aza-BODIPY-CNOH probe attached aldoxime group demonstrated the specific detection for hypochlorous acid by the turn-on red emission signal. NMR and HRMS experiments confirmed that the fluorescence originated from the oxidation degradation of the non-fluorescence, aldoxime-based aza-BODIPY-CNOH probe into the red-fluorescence, nitrile oxide-based aza-BODIPY compound aza-BODIPY-CNO. The aza-BODIPY-CNOH probe showed good biocompatibility and was low toxic to living cells as shown from MTT experiments. Living RAW264...
July 31, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
David Mou, Evan M Kleiman, Szymon Fedor, Stuart Beck, Jeff C Huffman, Matthew K Nock
Patients suffering from borderline personality disorder (BPD) are at elevated risk for suicidal thoughts and behaviors (STBs), but this well-described and clinically important association is not well-understood. Prior research suggests that STBs often function as an attempt to escape aversive affect, and that people with BPD experience stronger emotion reactivity and greater discomfort with emotion than those without BPD. Here, we tested whether negative affective states are more likely to predict suicidal thoughts among those with BPD than those without this disorder...
August 3, 2018: Journal of Psychiatric Research
Ya-Qing Du, Ju Tang, Zhen-Xiang Zhang, Jian Bian
BACKGROUND: In the present study, we aimed to inspect the correlation of interleukin-18 (IL-18) and high-sensitivity C-reactive protein (hs-CRP), if any present, with the occurrence of perioperative deep vein thrombosis (DVT) in patients suffering from an ankle fracture (AF). METHODS: 67 AF patients with complicated DVT (DVT group) and 448 AF patients without DVT (non-DVT group) were enrolled in the present study. To begin with, Hemorheological indexes were detected...
August 10, 2018: Annals of Vascular Surgery
Charles L Raison, Andrei Pikalov, Cynthia Siu, Joyce Tsai, Kenneth Koblan, Antony Loebel
Prior studies suggest that the inflammatory biomarker c-reactive protein (CRP) holds promise for predicting antidepressant response in patients with major depressive disorder. The objective of this study was to evaluate whether CRP might similarly predict antidepressant responses to lurasidone in patients with bipolar I depression. Serum CRP concentration was measured prior to, and following, 6 weeks of treatment in 485 outpatients with bipolar I depression. Patients were randomized to receive monotherapy with lurasidone 20-60 mg/day (N=161), lurasidone 80-120 mg/day (N=162) or placebo (N=162)...
August 10, 2018: Brain, Behavior, and Immunity
Yuan Cao, Xiaoyan Zhou, Zixiao Yin, Xinbo Yu, Qing Yang, Qikun Guo, Duxue Tian, Xiaoliang Xiong, Guogang Xu, Xiaodong Kuang
The aim of this study is to investigate whether the lipoxin receptor agonist BML-111 exerts a protective effect against inflammation in a mouse model of chronic obstructive pulmonary disease (COPD) by regulating NLRP3 inflammasome activation and reactive oxygen species (ROS) production. In this study, mice were randomly divided into the following five groups: control group (Control), COPD model group (Model), BML-111 low-dose group (Low-BML), BML-111 high-dose group (High-BML) and Dexamethasone group (Dex)...
August 10, 2018: Prostaglandins & Other Lipid Mediators
Christien Rondaan, Anoek A E de Joode, Sander van Assen, Nicolaas A Bos, Ralf Westerhuis, Johanna Westra
BACKGROUND: Patients in need of long-term renal replacement therapy (RRT) are known to be at increased risk of herpes zoster, occurring when the latently present varicella-zoster virus (VZV) reactivates. In this study we investigated immunity to VZV in patients receiving RRT, with the aim of better understanding the mechanism behind the increased risk. METHODS: Patients treated for at least three months with hemodialysis or peritoneal dialysis, and matched healthy controls (HC) were included...
August 10, 2018: Antiviral Research
Benigno C Valdez, Xiaowen Tang, Yang Li, David Murray, Yan Liu, Uday Popat, Richard E Champlin, Borje S Andersson
The combination of DNA alkylating agents busulfan (Bu) and cyclophosphamide is the most commonly used myeloablative pre-transplant conditioning therapy for myeloid leukemias. However, it is associated with significant non-relapse mortality, which prohibits dose-escalation to control relapse. We hypothesized that combining these two drugs with an epigenetic modifier would increase anti-leukemic efficacy without jeopardizing patient safety. A pre-clinical study was performed to determine the synergistic cytotoxicity of Bu, 4-hydroperoxycyclophosphamide (4HC) and the hypomethylating agent decitabine (DAC) in human AML cell lines...
August 10, 2018: Experimental Hematology
Jiangbiao Gong, Yu Zhu, Jianbo Yu, Jing Jin, Mantao Chen, Wenchao Liu, Renya Zhan
BACKGROUND: Interleukin-33 (IL-33) is an inflammatory biomarker. We elucidated the relationship between serum IL-33 concentrations, severity and prognosis in aneurysmal subarachnoid hemorrhage (aSAH). METHODS: We prospectively recruited 175 controls and 175 aSAH patients. Serum IL-33 concentrations were gauged using an enzyme-linked immunosorbent assay. Clinical and radiological severity was assessed by World Federation of Neurological Surgeons (WFNS) scale and modified Fisher grading scale respectively...
August 10, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
David J Koss, Marina Dubini, Heather Buchanan, Claire Hull, Bettina Platt
Alzheimer's disease (AD) pathology relevant proteins tau and beta-amyloid (Aβ) exist as an array of post-translationally modified and conformationally altered species with varying abundance, solubility and toxicity. Insoluble neurofibrillary tau tangles and Aβ plaques are end-stage AD hallmarks, yet may carry less disease significance compared to soluble species. At present, it is unclear how soluble and insoluble tau and Aβ relate to each other as well as to disease progression. Here, detergent soluble and insoluble fractions generated from post-mortem human temporal lobe samples (Brodmann area 21) were probed for tau and Aβ markers in immuno-dot assays...
August 10, 2018: Brain Research
Eduardo C Alexandre, Fabiano B Calmasini, Amanda C da S Sponton, Mariana G de Oliveira, Diana M André, Fábio H Silva, Maria Andréia Delbin, Fabíola Z Mónica, Edson Antunes
Obese mice display overactive bladder (OAB) associated with impaired urethra smooth muscle (USM) function. In this study, we evaluated the role of the adipose tissue surrounding the urethra and prostate in obese mice (here referred as periprostatic adipose tissue; PPAT) to the USM dysfunction. Male C57BL6/JUnib mice fed with either a standard-chow or high-fat diet to induce obesity were used. In PPAT, histological analysis, and qPCR analysis for gp91phox, tumor necrosis factor-α (TNF-α) and superoxide dismutase (SOD) were conducted...
August 10, 2018: European Journal of Pharmacology
Dieter Vanderelst, Herbert Peremans
Echolocating bats are the only mammals engaging in airborne pursuit. In this paper, we implement a reactive model of sonar based prey pursuit in bats. Our simulations include a realistic prey localization mechanism as well as a model of the bat's motor behavior. Critically, in contrast to previous work, our model incorporates bats' ability to execute rapid saccadic scanning motions keeping the prey within its field of view. Decoupling the flight direction from the gaze direction allows our model to capture erratically moving prey using reactive control...
August 10, 2018: Journal of Theoretical Biology
Kate Rundle, Mahmoud Sharaf, Don Stevens, Collins Kamunde, Michael R Van Den Heuvel
Naphthenic acids (NAs) are predominant compounds in oil sands-influenced waters. These acids cause numerous acute and chronic effects in fishes. However, the mechanism of toxicity underlying these effects has not been fully elucidated. Due to their carboxylic acid moiety and the reported disruption of cellular bioenergetics by similar structures, we hypothesized that NAs would uncouple mitochondrial respiration with the resultant production of reactive oxygen species (ROS). Naphthenic acids were extracted and purified from 17-year-old oil sands tailings waters yielding an extract of 99% carboxylic acids with 90% fitting the classical O2-NA definition...
August 13, 2018: Environmental Science & Technology
Swati Kumari, Ramona Gutkowski, Joao Junqueira, Aleksander Kostka, Katharina Hengge, Christina Scheu, Wolfgang Schuhmann, Alfred Ludwig
The search for suitable materials for solar water splitting is addressed with combinatorial material science methods. Thin film Fe-V-O materials libraries were synthesized using combinatorial reactive magnetron co-sputtering and subsequent annealing in air. The design of the libraries comprises a combination of large compositional gradients (from Fe10V90Ox to Fe79V21Ox) and thickness gradients (from 140 nm to 425 nm). These material libraries were investigated by high throughput characterization techniques in terms of composition, structure, optical and photoelectrochemical properties in order to establish correlations between composition, thickness, crystallinity, microstructure, and photocurrent density...
August 13, 2018: ACS Combinatorial Science
Afu Fu, Yu Ming Peh, Weida Ngan, Na Wei, Kathy Qian Luo
Treating systemic metastases at the micrometastatic stage is a potential strategy to inhibit cancer metastasis. This study aims to establish an apoptosis sensor-based platform for rapid, effective, and non-invasive identification of drugs that can inhibit the proliferation of micrometastatic cancer cells. We stably transfected the plasmid DNA encoding the fluorescence resonance energy transfer (FRET)-based caspase-3 sensor into highly metastatic melanoma B16F10 cells. The resulting B16F10-C3 cells were applied for screening of anti-proliferative and pro-apoptotic drugs in two-dimensional (2D) monolayer, three-dimensional (3D) spheroids, and zebrafish xenotransplantation tumors...
August 13, 2018: Biotechnology and Bioengineering
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