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https://www.readbyqxmd.com/read/30121947/nampt-signaling-is-critical-for-the-proangiogenic-activity-of-tumor-associated-neutrophils
#1
Ekaterina Pylaeva, Mozhgan Dehghan Harati, Ilona Spyra, Sharareh Bordbari, Sarah Strachan, Basant Kumar Thakur, Benedikt Höing, Cindy Franklin, Julia Skokowa, Karl Welte, Dirk Schadendorf, Agnes Bankfalvi, Sven Brandau, Stephan Lang, Jadwiga Jablonska
Tumor-associated neutrophils regulate many processes associated with tumor progression, and depending on the microenvironment, they can exhibit pro- or antitumor functions. However, the molecular mechanisms regulating their tumorigenicity are not clear. Using transplantable tumor models, we showed here that Nicotinamide Phosphoribosyltransferase (NAMPT), a molecule involved in CSF3R downstream signaling, is essential for tumorigenic conversion of tumor-associated neutrophils and their pro-angiogenic switch...
August 19, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/30121877/behavioral-trajectories-during-middle-childhood-differential-effects-of-the-school-wide-positive-behavior-support-model
#2
Mari-Anne Sørlie, Thormod Idsoe, Terje Ogden, Asgeir Røyrhus Olseth, Torbjørn Torsheim
The aims of this study were to assess the longitudinal trajectories of externalizing problem behavior during middle childhood among typically developing children and to examine subgroup differences in the effectiveness of the School-Wide Positive Behavior Support (SWPBS) model, called N-PALS in Norway. Participants were approximately 3000 students, and behavioral assessments were performed by class head teachers at four time points from the 4th or 5th grade through the 7th grade. Using a combination of latent class growth analyses (LCGA) and growth mixture modeling (GMM), four distinct trajectory classes were identified, i...
August 18, 2018: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/30121648/mir-122-5p-inhibits-the-proliferation-invasion-and-growth-of-bile-duct-carcinoma-cells-by-targeting-aldoa
#3
Zhuo Xu, Guangchao Liu, Meng Zhang, Zhilei Zhang, Yuming Jia, Li Peng, Yanhong Zhu, Jianbin Hu, Runying Huang, Xiaonan Sun
BACKGROUND/AIMS: Bile duct cancer, although not among the most common tumors, still accounts for more and more worldwide deaths each year. By attempting to verify an overexpression of ALDOA in cholangiocarcinoma tissues and cells and explore the underlying molecular mechanism regulated by miR-122-5p, this study was designed to provide a potential molecular target in bile duct cancer treatment. METHODS: Western blot and immunohistochemistry were performed to detect the ALDOA protein level in duct carcinoma tissues...
August 17, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/30121627/switchable-car-t-cells-mediate-remission-in-metastatic-pancreatic-ductal-adenocarcinoma
#4
Deepak Raj, Ming-Hsin Yang, David Rodgers, Eric N Hampton, Julfa Begum, Arif Mustafa, Daniela Lorizio, Irene Garces, David Propper, James G Kench, Travis S Young, Alexandra Aicher, Christopher Heeschen
OBJECTIVE: Pancreatic ductal adenocarcinoma (PDAC) is a disease of unmet medical need. While immunotherapy with chimeric antigen receptor T (CAR-T) cells has shown much promise in haematological malignancies, their efficacy for solid tumours is challenged by the lack of tumour-specific antigens required to avoid on-target, off-tumour effects. Switchable CAR-T cells whereby activity of the CAR-T cell is controlled by dosage of a tumour antigen-specific recombinant Fab-based 'switch' to afford a fully tunable response may overcome this translational barrier...
August 18, 2018: Gut
https://www.readbyqxmd.com/read/30121626/prediagnostic-circulating-markers-of-inflammation-and-risk-of-oesophageal-adenocarcinoma-a-study-within-the-national-cancer-institute-cohort-consortium
#5
Michael B Cook, Matthew J Barnett, Cathryn H Bock, Amanda J Cross, Phyllis J Goodman, Gary E Goodman, Christopher A Haiman, Kay-Tee Khaw, Marjorie L McCullough, Christine C Newton, Marie-Christine Boutron-Ruault, Eiliv Lund, Martin Rutegård, Mark D Thornquist, Michael Spriggs, Carol Giffen, Neal D Freedman, Troy Kemp, Candyce H Kroenke, Loïc Le Marchand, Jin Young Park, Michael Simon, Lynne R Wilkens, Ligia Pinto, Allan Hildesheim, Peter T Campbell
OBJECTIVE: Cross-sectional data indicate that systemic inflammation is important in oesophageal adenocarcinoma. We conducted a prospective study to assess whether prediagnostic circulating markers of inflammation were associated with oesophageal adenocarcinoma and to what extent they mediated associations of obesity and cigarette smoking with cancer risk. DESIGN: This nested case-control study included 296 oesophageal adenocarcinoma cases and 296 incidence density matched controls from seven prospective cohort studies...
August 18, 2018: Gut
https://www.readbyqxmd.com/read/30121495/a-hybrid-approach-for-multiple-blastomeres-identification-in-early-human-embryo-images
#6
Reza Moradi Rad, Parvaneh Saeedi, Jason Au, Jon Havelock
Automatic quality assessment of the human embryo paves the way to improve the outcome of the In Vitro Fertilization (IVF) treatment by selecting embryos with the highest implantation potentials. Analyzing the shape, size, and motion of the cells, as well as other time-related changes, facilitates embryo quality assessment. However, the ambitious 3D-like side-lit appearance of the embryo, occlusion, transparency of cells and artifacts such as fragmentation make automatic detection of blastomeres (embryonic cells) a challenging task...
August 8, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/30121494/mmb-triazole-analogs-are-potent-nf-%C3%AE%C2%BAb-inhibitors-and-anti-cancer-agents-against-both-hematological-and-solid-tumor-cells
#7
Venumadhav Janganati, Jessica Ponder, Meenakshisundaram Balasubramaniam, Poornima Bhat-Nakshatri, Eli E Bar, Harikrishna Nakshatri, Craig T Jordan, Peter A Crooks
Triazole derivatives of melampomagnolide B (MMB) have been synthesized via click chemistry methodologies and screened against a panel of 60 human cancer cell lines. Several derivatives showed promising anti-cancer activity, affording growth inhibition (GI50 ) values in the nanomolar range (GI50  = 0.02-0.99 μM). Lead compound 7h exhibited EC50 values of 400 nM and 700 nM, respectively, against two AML clinical specimens. Compound 7h was significantly more potent than parthenolide as an inhibitor of p65 phosphorylation in both hematological and solid tumor cell lines, indicating its ability to inhibit the NF-κB pathway...
August 10, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/30121486/chronic-toxicity-of-an-environmentally-relevant-and-equitoxic-ratio-of-five-metals-to-two-antarctic-marine-microalgae-shows-complex-mixture-interactivity
#8
Darren J Koppel, Merrin S Adams, Catherine K King, Dianne F Jolley
Metal contaminants are rarely present in the environment individually, yet environmental quality guidelines are derived from single-metal toxicity data. Few metal mixture studies have investigated more than binary mixtures and many are at unrealistically high effect concentrations to freshwater organisms. This study investigates the toxicity of five metals (Cd, Cu, Ni, Pb, and Zn) to the Antarctic marine microalgae Phaeocystis antarctica and Cryothecomonas armigera. Two mixtures were tested: (i) an equitoxic mixture of contaminants present at their single-metal EC10 concentrations, and (ii) an environmental mixture based on the ratio metal concentrations in a contaminated Antarctic marine bay...
July 25, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/30121426/fluoropolymers-for-intracellular-and-in-vivo-protein-delivery
#9
Jia Lv, Bingwei He, Jingwen Yu, Yitong Wang, Changping Wang, Song Zhang, Hui Wang, Jingjing Hu, Qiang Zhang, Yiyun Cheng
The design of efficient and universal carriers to transport proteins into cells is highly desirable in the development of biotherapeutics. However, intracellular protein delivery remains a major challenge owing to the multiple barriers in protein delivery process, such as protein encapsulation, endocytosis, endosomal escape and intracellular protein release. Recently, it was reported that fluorination on polymers is beneficial for their self-assembly and intracellular trafficking. We hypothesize the fluoropolymers can be used to encapsulate proteins and developed as a new class of carriers to break down the barriers during intracellular protein delivery...
August 9, 2018: Biomaterials
https://www.readbyqxmd.com/read/30121385/nanoformulations-of-anticancer-fgfr-inhibitors-with-improved-therapeutic-index
#10
Sebastian Kallus, Bernhard Englinger, Julia Senkiv, Anna Laemmerer, Petra Heffeter, Walter Berger, Christian R Kowol, Bernhard K Keppler
Fibroblast growth factor receptor (FGFR) inhibitors like ponatinib and nintedanib are clinically approved for defined cancer patient cohorts but often exert dose-limiting adverse effects. Hence, we encapsulated FGFR inhibitors ponatinib, PD173074, and nintedanib into polylactic acid nanoparticles and liposomes to enable increased tumor accumulation/specificity and reduce side effects. Different methods of drug loading were tested and the resulting formulations compared regarding average size distribution as well as encapsulation efficiency...
August 16, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/30121216/sympathetic-nervous-remodeling-is-induced-in-the-intermediolateral-nucleus-after-myocardial-infarction-role-of-bdnf-trkb-axis
#11
Minoru Nodera, Masayoshi Oikawa, Kazuhiko Nakazato, Takafumi Ishida, Yasuchika Takeishi
Several studies have shown that neural remodeling in stellate ganglia (SG) is induced by myocardial infarction (MI). It remains unclear whether neural remodeling after MI is limited in SG within the sympathetic nervous system (SNS). MI was induced in a rat model by ligation of the left anterior descending artery. Neural remodeling in the intermediolateral nucleus (IML) and SG was assessed by immunohistochemistry 2 weeks after MI. The mRNA and protein expressions of brain-derived neurotrophic factor (BDNF), tropomyosin-related kinase receptor (TrkB) and extracellular signal-regulated kinase (ERK) were measured by quantitative RT-PCR, immunohistochemistry and Western blotting 1 week after MI...
August 16, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/30121214/optimization-of-diarylpentadienones-as-chemotherapeutics-for-prostate-cancer
#12
Manee Patanapongpibul, Changde Zhang, Guanglin Chen, Shanchun Guo, Qiang Zhang, Shilong Zheng, Guangdi Wang, Qiao-Hong Chen
Our earlier studies indicate that (1E,4E)-1,5-bis(1-alkyl-1H-imidazol-2-yl)penta-1,4-diene-3-ones and (1E,4E)-1,5-bis(1-alkyl-1H-benzo[d]imidazol-2-yl)penta-1,4-diene-3-ones exhibit up to 121-fold greater antiproliferative potency than curcumin in human prostate cancer cell models, but only 2-10 fold increase in mouse plasma concentrations. The present study aims to further optimize them as anti-prostate cancer agents with both good potency and bioavailability. (1E,4E)-1,5-Bis(1H-imidazol-2-yl)penta-1,4-diene-3-one, the potential metabolic product of (1E,4E)-1,5-bis(1-alkyl-1H-imidazol-2-yl)penta-1,4-diene-3-ones, was synthesized and evaluated for its anti-proliferative activity...
August 13, 2018: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/30121056/octreotide-ameliorates-dermal-fibrosis-in-bleomycin-induced-scleroderma
#13
Sibel Oyucu Orhan, Ahmet Tektemur, Nevzat Gözel, İbrahim Hanifi Özercan, Servet Yolbaş, Ahmet Yıldırım, Ebru Önalan, Süleyman Serdar Koca
Background/aim: Insulin-like growth factor (IGF)-I is a differentiation and growth factor. Antifibrotic action of octreotide has been reported in pulmonary fibrosis. The present study aimed to research the prophylactic and therapeutic potential of octreotide on a bleomycin (BLM)-induced experimental scleroderma model. Materials and methods: Sixty Balb/c female mice were divided into 6 groups. Daily subcutaneous BLM (100 μg) was injected for 3 weeks in groups II and III and for 6 weeks in groups V and VI...
August 16, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/30120964/fty720-enhances-the-anti-tumor-activity-of-carboplatin-and-tamoxifen-in-a-patient-derived-xenograft-model-of-ovarian-cancer
#14
Kelly M Kreitzburg, Samuel C Fehling, Charles N Landen, Tracy L Gamblin, Rebecca B Vance, Rebecca C Arend, Ashwini A Katre, Patsy G Oliver, Robert C A M van Waardenburg, Ronald D Alvarez, Karina J Yoon
Ovarian cancer is the fifth leading cause of cancer-related deaths among women in the United States. Although most patients respond to frontline therapy, virtually all patients relapse with chemoresistant disease. This study addresses the hypothesis that carboplatin or tamoxifen + FTY720, a sphingosine analogue, will minimize or circumvent drug-resistance in ovarian cancer cells and tumor models. In vitro data demonstrate that FTY720 sensitized two drug-resistant (A2780. cp20, HeyA8. MDR) and two high-grade serous ovarian cancer cell lines (COV362, CAOV3) to carboplatin, a standard of care for patients with ovarian cancer, and to the selective estrogen receptor modulator tamoxifen...
August 15, 2018: Cancer Letters
https://www.readbyqxmd.com/read/30120860/lncrna-fendrr-mediates-vegfa-to-promote-the-apoptosis-of-brain-microvascular-endothelial-cells-via-regulating-mir-126-in-mice-with-hypertensive-intracerebral-hemorrhage
#15
Baizhuo Dong, Zhigang Sun, Bin Zhou, Shengming Huang, Liang Han, Honghua Nie, Guohui Chen, Shibing Liu, Yanna Zhang, Ning Bao, Xiaolong Yang, Hongwei Feng
BACKGROUND: LncRNA-FENDRR is a kind of endothelial genes critical for vascular development. Moreover, miR-126 and vascular endothelial growth factor A (VEGFA) are also involved in the physiological process of vascular endothelial cells. This study aimed to the underlying mechanism of FENDRR involving miR-126 and VEGFA in hypertensive intracerebral hemorrhage (HICH). METHODS: C57BL/6 mice were chosen to establish HICH model. The expression of FENDRR, miR-126 and VEGFA at mRNA level were determined by qRT-PCR...
August 18, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/30120682/the-differential-time-varying-effect-model-dtvem-a-tool-for-diagnosing-and-modeling-time-lags-in-intensive-longitudinal-data
#16
Nicholas C Jacobson, Sy-Miin Chow, Michelle G Newman
With the recent growth in intensive longitudinal designs and the corresponding demand for methods to analyze such data, there has never been a more pressing need for user-friendly analytic tools that can identify and estimate optimal time lags in intensive longitudinal data. The available standard exploratory methods to identify optimal time lags within univariate and multivariate multiple-subject time series are greatly underpowered at the group (i.e., population) level. We describe a hybrid exploratory-confirmatory tool, referred to herein as the Differential Time-Varying Effect Model (DTVEM), which features a convenient user-accessible function to identify optimal time lags and estimate these lags within a state-space framework...
August 17, 2018: Behavior Research Methods
https://www.readbyqxmd.com/read/30120661/bevacizumab-irinotecan-temozolomide-tyrosine-kinase-inhibition-and-mek-inhibition-are-effective-against-pleomorphic-xanthoastrocytoma-regardless-of-v600e-status
#17
Eric M Thompson, Daniel Landi, David Ashley, Stephen T Keir, Darell Bigner
INTRODUCTION: Pleomorphic xanthoastrocytoma (PXA) is a rare Grade II and III glioma. Surgical resection is the mainstay of treatment, however, adjuvant therapy is sometimes necessary. Given the rarity of PXA, chemotherapeutic efficacy data is limited. The importance of the BRAF V600E mutation in the context of MAP kinase pathway inhibition is unknown. The purpose of this study was to perform an in vivo screen of a variety to agents to determine efficacy against both V600E mutant and non-mutant PXA...
August 17, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/30120629/modified-fe-3-o-4-magnetic-nanoparticle-delivery-of-cpg-inhibits-tumor-growth-and-spontaneous-pulmonary-metastases-to-enhance-immunotherapy
#18
Xueyan Zhang, Fengbo Wu, Ke Men, Rong Huang, Bailin Zhou, Rui Zhang, Rui Zou, Li Yang
As a novel toll-like receptor 9 (TLR9) agonist, synthetic unmethylated cytosine-phosphate-guanine (CpG) oligodeoxynucleotides can stimulate a Th1 immune response and potentially be used as therapeutic agents or vaccine adjuvants for the treatment of cancer. However, some drawbacks of CpG limit their applications, such as rapid elimination by nuclease-mediated degradation and poor cellular uptake. Therefore, repeat high-dose drug administration is required for treatment. In this work, a CpG delivery system based on 3-aminopropyltriethoxysilane (APTES)-modified Fe3 O4 nanoparticles (FeNPs) was designed and studied for the first time to achieve better bioactivity of CpG...
August 17, 2018: Nanoscale Research Letters
https://www.readbyqxmd.com/read/30120625/pluronic-f127-blended-polycaprolactone-scaffolds-via-e-jetting-for-esophageal-tissue-engineering
#19
Bin Wu, Nobuyoshi Takeshita, Yang Wu, Sanjairaj Vijayavenkataraman, Khek Yu Ho, Wen Feng Lu, Jerry Ying Hsi Fuh
Several attempts have been made to fabricate esophageal tissue engineering scaffolds. However, most of these scaffolds possess randomly oriented fibres and uncontrollable pore sizes. In order to mimic the native esophageal tissue structure, electro-hydrodynamic jetting (e-jetting) was used in this study to fabricate scaffolds with aligned fibres and controlled pore size. A hydrophilic additive, Pluronic F127 (F127), was blended with polycaprolactone (PCL) to improve the wettability of the scaffolds and hence the cell adhesion...
August 17, 2018: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/30120430/socioeconomic-inequalities-in-weight-height-and-body-mass-index-from-birth-to-5-years
#20
M Ballon, J Botton, M A Charles, S Carles, B de Lauzon-Guillain, A Forhan, A J Cameron, B Heude, S Lioret
BACKGROUND/OBJECTIVES: Studies in high-income countries show that despite the positive association of weight with socioeconomic position at birth, an inverse socioeconomic gradient in overweight (OW) appears later in childhood. The objectives were to understand the natural history of socioeconomic inequalities in weight, height and body mass index (BMI), by investigating their associations with maternal educational level between birth and 5 years, separately in boys and girls. SUBJECTS/METHODS: A published work of growth modelling between birth and 5 years allowed us to calculate predicted weight, height and BMI at 1 month, 6 months, 1, 3 and 5 years for 1735 children from the French EDEN mother-child cohort...
August 17, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
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