Olivier Le Bacquer, Phelipe Sanchez, Véronique Patrac, César Rivoirad, Nicolas Saroul, Christophe Giraudet, Ayhan Kocer, Stephane Walrand
Cancer and chemotherapy can both cause cachexia, a complex multi-organ syndrome characterized by body weight loss, due to adipose tissue and skeletal muscle wasting. Changes in body weight and muscle mass are predictive of response to chemotherapy, incidence of treatment-related complications and, ultimately, patient survival, but there are currently still no clear therapeutic strategies to counteract cachexia. Cannabidiol (CBD) is a bioactive phytocannabinoid produced from a plant named Cannabis sativa . In recent years, CBD has demonstrated beneficial effects on maintaining skeletal muscle mass, function and metabolism in models of muscular dystrophy or diet-induced obesity...
February 26, 2024: American Journal of Physiology. Cell Physiology