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https://www.readbyqxmd.com/read/30552864/first-report-of-two-consecutive-respiratory-syncytial-virus-outbreaks-by-the-novel-genotypes-on-1-and-na-2-in-a-neonatal-intensive-care-unit
#1
Daniella Gregoria Bomfim Prado da Silva, Flávia Jacqueline Almeida, Mariana Volpe Arnoni, Marco Aurélio Palazzi Sáfadi, Marcelo Jenne Mimica, Daniel Jarovsky, Gabriela Pereira de Almeida Rossetti, Mauricio Magalhães, Danielle Bruna Leal de Oliveira, Luciano Matsumiya Thomazelli, Thais Cristina Colmanetti, Edison Luiz Durigon, Eitan Naaman Berezin
OBJECTIVE: Respiratory syncytial virus is a pathogen frequently involved in nosocomial outbreaks. Although several studies have reported nosocomial outbreaks in neonatal intensive care units, molecular epidemiology data are scarce. Here, the authors describe two consecutive respiratory syncytial virus outbreaks caused by genotypes ON-1 and NA-2 in a neonatal intensive care unit in São Paulo, Brazil. METHODS: A prospective search for respiratory syncytial virus was performed after diagnosing the index case and four other symptomatic newborns in the neonatal intensive care unit...
December 12, 2018: Jornal de Pediatria
https://www.readbyqxmd.com/read/30523661/standardization-of-nitric-oxide-inhalation-in-extremely-preterm-infants-in-japan
#2
Jun Shiraishi, Satoshi Kusuda, Kazutoshi Cho, Atsushi Nakao, Takehiko Hiroma, Hiroshi Sugiura, Satoshi Suzuki, Makoto Oshiro, Seiji Yoshimoto, Shinichi Watabe
BACKGROUND: In perinatal medicine, inhaled nitric oxide (iNO) has been an important tool for the treatment of full-term and late-preterm infants with persistent pulmonary hypertension of the newborn (PPHN) and hypoxemic respiratory failure (HRF). However, its use in more premature infants is controversial. To evaluate the current clinical practices regarding use of acute inhaled nitric oxide (iNO) therapy in extremely preterm infants, a nationwide survey was conducted in Japan. METHODS: A questionnaire survey was conducted from May to September, 2015...
December 6, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/30521741/maternal-and-perinatal-outcomes-of-expectant-treatment-of-severe-preeclampsia
#3
Juan Gustavo Vázquez-Rodríguez, Dulce Yadira Barboza-Alatorre
Background: In severe preeclampsia (SP), pregnancy interruption is the first recommendation. However, some patients receive expectant treatment. Objetive: To determine maternal and perinatal results of expectant treatment of SP in the intensive care unit (ICU) of a high-specialty hospital. Methods: Observational, descriptive and retrospective study; the files of 40 pregnant patients with SP managed in the ICU with expectant treatment were reviewed...
November 30, 2018: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/30521458/-morbidity-in-prematurity-associated-with-fetal-growth-restriction-experience-of-a-tertiary-care-center
#4
Noémia Rosado Silva, Joana Oliveira, Alberto Berenguer, André M Graça, Margarida Abrantes, Carlos Moniz
INTRODUCTION: Prematurity and low birth weight have been associated with increased neonatal morbidity and mortality. This study aimed to evaluate possible risk factors for prematurity associated with fetal growth restriction and being small for gestational age and to determine the incidence of morbidity in these two groups of infants. MATERIAL AND METHODS: Retrospective case-control study of newborns with gestational age of less than 32 weeks, with obstetric diagnosis of fetal growth restriction and with the clinical diagnosis of small for gestational age, admitted to the Neonatal Intensive Care Unit of a tertiary hospital for a period of six years...
November 30, 2018: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/30513543/-treatment-of-hiv-in-pregnancy-progress-over-one-decade
#5
Isabelle Catherine Pitzen, Lucia Anna Otten, Till Dresbach, Christoph Boesecke, Jan-Christian Wasmuth, Andreas Mueller, Ulrich Gembruch, Waltraut M Merz, Christian P Strassburg, Annette Haberl, Juergen K Rockstroh, Silvia Poralla, Carolynne Schwarze-Zander
INTRODUCTION: Worldwide, 37 million people are infected with HIV; more than 50% are women. Currently, MTCT (mother-to-child transmission) can be reduced to<1%. The intention of the present study was to analyze the development of (1) the course of pregnancy of HIV-infected women, (2) the mode of delivery and (3) the post-exposure prophylaxis of the newborn over the last decade. METHODOLOGY: In this retrospective study, data from HIV-infected women who between 2005 and 2016 received care at the HIV outpatient department and gave birth at the Department of Obstetrics at University Hospital Bonn was analyzed...
December 4, 2018: Zeitschrift Für Geburtshilfe und Neonatologie
https://www.readbyqxmd.com/read/30507374/characterization-of-a-multidrug-resistant-klebsiella-pneumoniae-st607-k25-clone-responsible-for-a-nosocomial-outbreak-in-a-neonatal-intensive-care-unit
#6
F Peltier, M Choquet, V Decroix, C C Adjidé, S Castelain, R Guiheneuf, E Pluquet
PURPOSE: Multidrug-resistant Klebsiella pneumoniae strains are regularly involved in hospital outbreaks. This study describes an ESBL-producing K. pneumoniae clone (ST607-K25) responsible for a nosocomial outbreak in a neonatal intensive care unit. METHODOLOGY: Fourteen strains isolated from 13 patients were included. Antimicrobial susceptibility testing was performed by the agar diffusion method. A clonal link was first investigated by fingerprinting (ERIC-PCR and REP-PCR) then confirmed by MLST...
December 3, 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/30499415/long-term-outcome-of-infants-with-nec
#7
S Federici, L De Biagi
Necrotizing enterocolitis (NEC) is a significant complication for premature newborns. Infants who survive NEC are at increased risk of having poor long-term physiological and neurodevelopmental growth. The objective of this paper is to give a comprehensive description of the long-term consequences of NEC. Despite the rise in incidence of NEC there is a paucity of data regarding long-term outcomes of these infants that can be divided into two groups. The first group includes gastrointestinal complications that could occur in relation to the bowel disease, the surgical treatment and quality of the residual bowel...
November 30, 2018: Current Pediatric Reviews
https://www.readbyqxmd.com/read/30457716/results-of-the-national-program-for-the-prevention-of-blindness-in-childhood-by-retinopathy-of-prematurity-in-argentina-2004-2016
#8
Ernesto Alda, Celia C Lomuto, Alicia M Benítez, Liliana Bouzas, Marina Brussa, Adriana Cattaino, N Alejandro Dinerstein, Norma Erpen, Lidia Galina, Celeste Mansilla, Silvia Marinaro, Ana Quiroga, Gabriela Saidman, Celia Sánchez, Teresa Sepúlveda, Patricia Visintin
INTRODUCTION: The ROP Argentina Group was created in 2003 and is responsible for the National Program for the Prevention of Blindness in Childhood by Retinopathy of Prematurity (ROP) in Argentina. OBJETIVES: To describe the program implementation and results achieved in relation to ROP care in terms of effectiveness, access, and quality (2004-2016). POPULATION AND METHODS: Descriptive, retrospective study with a dynamic cohort carried out in facilities that are part of the registry...
December 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/30455518/public-health-system-integration-of-avoidable-blindness-screening-and-management-india
#9
Venkata Sm Gudlavalleti, Rajan Shukla, Tripura Batchu, Bala Vidyadhar S Malladi, Clare Gilbert
In India, 73 million people have diabetes and 3.5 million infants are born preterm. Without timely screening, there is a risk of visual loss due to diabetic retinopathy and retinopathy of prematurity in these two groups, respectively. Both conditions are emerging causes of visual impairment in India but there is no public health programme for screening or management. Pilot projects were initiated in 2014 to integrate the screening and management of these conditions into existing public health systems, particularly in rural communities and their referral networks...
October 1, 2018: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/30407356/two-case-reports-of-neonatal-autoantibody-associated-congenital-heart-block
#10
Xiaoxia Li, Xianmei Huang, Hui Lu
RATIONALE: Neonatal lupus erythematosus (NLE) is an infrequent disease caused by transplacental maternal autoantibodies. The most common effects of NLE include cutaneous involvement and congenital heart block (CHB), although it might involve multiple organs, such as the liver, lungs, blood, and nervous or digestive systems. Izmirly PM1 and Tonello et al recently reported cutaneous manifestations of neonatal lupus and risk of subsequent CHB. The most serious complication of NLE is complete atrioventricular (AV) block...
November 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30384032/impact-of-parental-incarceration-on-neonatal-outcomes-and-newborn-home-environments-a-case-control-study
#11
D H Dallaire, A Woodards, C Kelsey
OBJECTIVES: Parental incarceration (PI) is a prevalent adverse childhood experience (ACE) that has been linked to numerous social, emotional, and health problems in childhood and adulthood. A growing body of research has emphasized the importance of the timing of parent's incarceration on developmental outcomes. STUDY DESIGN: The present study uses case-control matching to examine the impact of recent PI on newborn health and home safety outcomes. METHODS: Neonatal health and newborn sleep and home safety data, including rates of premature birth, low birth weight (LBW), neonatal intensive care unit admittance, breastfeeding initiation, safe sleep, and home environment (e...
October 26, 2018: Public Health
https://www.readbyqxmd.com/read/30365906/hemoglobin-oxygen-saturation-targets-in-the-neonatal-intensive-care-unit-is-there-a-light-at-the-end-of-the-tunnel
#12
Payam Vali, Mark A Underwood, Satyan Lakshminrusimha
The optimal oxygenation target to avoid the extremes of hypoxia and oxygen toxicity in premature and sick newborns has been the subject of much research and debate. The advent of the pulse oximeter has provided a means to continuously monitor oxyhemoglobin saturations (SpO2) and to deliver oxygen with greater precision. Well conducted, large clinical trials to determine the safest oxygen concentration have led to several revisions in guidelines for neonatal care. However, SpO2 monitoring has its own limitations and does not provide a comprehensive assessment of tissue oxygenation...
October 26, 2018: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/30344873/the-effect-of-kangaroo-mother-care-on-physiological-parameters-of-premature-infants-in-hamadan-city-iran
#13
RANDOMIZED CONTROLLED TRIAL
Parisa Parsa, Simin Karimi, Behnaz Basiri, Godratalah Roshanaei
Introduction: Breast-feeding and being with mother have positive effects on the preterm infant's health status. Therefore, this study was conducted to evaluate the effect of Kangaroo Mother Care (KMC) on physiological parameters of premature infants in Fatemiyeh Hospital in Hamadan in 2016. Methods: This was a quasi-experimental study. One hundred newborns who were admitted to in neonatal intensive care unit of Fatemiyeh Hospital in Hamadan city, Iran were selected by convenience sampling...
2018: Pan African Medical Journal
https://www.readbyqxmd.com/read/30340943/regular-and-prolonged-skin-to-skin-contact-improves-short-term-outcomes-for-very-preterm-infants-a-dose-dependent-intervention
#14
C Casper, I Sarapuk, H Pavlyshyn
INTRODUCTION: Skin-to-skin contact (SSC) is a cornerstone of neurodevelopment and family-oriented care for preterm infants. The purpose of the present study was to investigate the effectiveness of skin-to-skin contact in preterm babies depending on regularity, duration, and the period of the first contact. MATERIALS AND METHODS: This retrospective study involved 26 premature infants with gestational age 24/0-28/6 weeks who were treated in the neonatal intensive care unit and neonatal department...
November 2018: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/30325465/a-prediction-model-for-neonatal-mortality-in-low-and-middle-income-countries-an-analysis-of-data-from-population-surveillance-sites-in-india-nepal-and-bangladesh
#15
Tanja A J Houweling, David van Klaveren, Sushmita Das, Kishwar Azad, Prasanta Tripathy, Dharma Manandhar, Melissa Neuman, Erik de Jonge, Jasper V Been, Ewout Steyerberg, Anthony Costello
Background: In poor settings, where many births and neonatal deaths occur at home, prediction models of neonatal mortality in the general population can aid public-health policy-making. No such models are available in the international literature. We developed and validated a prediction model for neonatal mortality in the general population in India, Nepal and Bangladesh. Methods: Using data (49 632 live births, 1742 neonatal deaths) from rural and urban surveillance sites in South Asia, we developed regression models to predict the risk of neonatal death with characteristics known at (i) the start of pregnancy, (ii) start of delivery and (iii) 5 minutes post partum...
October 15, 2018: International Journal of Epidemiology
https://www.readbyqxmd.com/read/30289125/determinants-of-preterm-birth-at-jimma-university-medical-center-southwest-ethiopia
#16
Mohammed Abaraya, Sheka Shemsi Seid, Shemsedin Amme Ibro
Background: Preterm birth is the second leading cause of death next to pneumonia in children aged <5 years and the single-most important cause of death in the first month of life. Research examining determinants of preterm birth in Ethiopia is limited. Therefore, this study aimed to determine risk factors associated with preterm births at Jimma University Medical Center in southwest Ethiopia. Methods: This unmatched case-control study was conducted from March 15 to April 1, 2017 from medical records of mothers and newborns delivered at Jimma University Medical Center from January 1 to December 30, 2016...
2018: Pediatric Health, Medicine and Therapeutics
https://www.readbyqxmd.com/read/30270165/neonatal-outcomes-in-extremely-preterm-newborns-admitted-to-intensive-care-after-no-active-antenatal-management-a-population-based-cohort-study
#17
Caroline Diguisto, Laurence Foix L'Helias, Andrei S Morgan, Pierre-Yves Ancel, Gilles Kayem, Monique Kaminski, Franck Perrotin, Babak Khoshnood, Francois Goffinet
OBJECTIVE: To evaluate the association between active antenatal management and neonatal outcomes in extremely preterm newborns admitted to a neonatal intensive care unit (NICU). STUDY DESIGN: This population-based cohort study was conducted in 25 regions of France. Infants born in 2011 between 220/7 and 266/7 weeks of gestation and admitted to a NICU were included. Infants with lethal congenital malformations or death in the delivery room were excluded. A multilevel multivariable analysis was performed, accounting for clustering by mother (multiple pregnancies) and hospital plus individual characteristics, to estimate the association between the main exposure of no active antenatal management (not receiving antenatal corticosteroids, magnesium sulfate, or cesarean delivery for fetal indications) and a composite outcome of death or severe neonatal morbidity (including severe forms of brain or lung injury, retinopathy of prematurity, and necrotizing enterocolitis)...
September 27, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/30262148/dietary-approaches-to-stop-hypertension-diet-and-activity-to-limit-gestational-weight-maternal-offspring-metabolics-family-intervention-trial-a-technology-enhanced-randomized-trial
#18
Linda Van Horn, Alan Peaceman, Mary Kwasny, Eileen Vincent, Angela Fought, Jami Josefson, Bonnie Spring, Lisa M Neff, Niki Gernhofer
INTRODUCTION: Technology-enhanced antenatal diet and lifestyle intervention could prevent excess gestational weight gain and benefit mother and child. STUDY DESIGN: A randomized clinical trial. SETTING/PARTICIPANTS: Overweight and obese ethnically diverse pregnant women in Chicago, Illinois, were enrolled between October 2012 and December 2015, with antenatal data collection completed by July 2016. Analysis was completed June 2017. INTERVENTION: Participants were randomized when their fetus was gestational age 16 weeks to dietitian-led Dietary Approaches to Stop Hypertension diet and physical activity coaching that was received as three individual and six group counseling sessions by phone and webinar...
November 2018: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/30245147/prevention-of-meconium-obstruction-in-very-low-birth-weight-preterm-infants
#19
A J Solaz-García, L Segovia-Navarro, J L Rodríguez de Dios-Benlloch, L Benavent-Taengua, D Y Castilla-Rodríguez, M A Company-Morenza
INTRODUCTION: Delayed meconium expulsion is a cause of bowel obstruction in the extremely premature newborn (<28 WGE) weighing less than 1500g at birth. OBJECTIVE: To evaluate the efficacy of conservative treatment in the prevention of meconium obstruction in very-low-birt- weight preterm infants. METHOD: Descriptive and retrospective study performed at the Neonatal Intensive Care Unit of a tertiary level hospital. All very-low-birth-weight preterm infants who were born during the study period, from August 2016 to January 2017, and who had meconium obstruction were included...
September 20, 2018: Enfermería Intensiva
https://www.readbyqxmd.com/read/30243953/knockdown-of-lncrna-malat1-contributes-to-cell-apoptosis-via-regulating-nf-%C3%AE%C2%BAb-cd80-axis-in-neonatal-respiratory-distress-syndrome
#20
Chenxia Juan, Qian Wang, Yan Mao, Qian Cao, Sheng Li, Chunmin Qiao, Daoqi Zhang, Guoping Zhou
Neonatal respiratory distress syndrome (NRDS) is a leading cause of morbidity in premature newborns and is a common reason for admission to the neonatal intensive care unit (NICU). Recent studies found that the pathogenesis of NRDS is not simply lung immaturity. Apoptosis is an essential process for the development and maturation of the lungs. In this study, we report a critical role of lncRNA MALAT1 in regulating CD80 transcription in the NRDS-associated apoptosis via binding with NF-κB. We first showed MALAT1 and CD80 were highly expressed in the peripheral blood mononuclear cells of NRDS with infection exposure...
November 2018: International Journal of Biochemistry & Cell Biology
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