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Newborn, care, premature

Tanja A J Houweling, David van Klaveren, Sushmita Das, Kishwar Azad, Prasanta Tripathy, Dharma Manandhar, Melissa Neuman, Erik de Jonge, Jasper V Been, Ewout Steyerberg, Anthony Costello
Background: In poor settings, where many births and neonatal deaths occur at home, prediction models of neonatal mortality in the general population can aid public-health policy-making. No such models are available in the international literature. We developed and validated a prediction model for neonatal mortality in the general population in India, Nepal and Bangladesh. Methods: Using data (49 632 live births, 1742 neonatal deaths) from rural and urban surveillance sites in South Asia, we developed regression models to predict the risk of neonatal death with characteristics known at (i) the start of pregnancy, (ii) start of delivery and (iii) 5 minutes post partum...
October 15, 2018: International Journal of Epidemiology
Mohammed Abaraya, Sheka Shemsi Seid, Shemsedin Amme Ibro
Background: Preterm birth is the second leading cause of death next to pneumonia in children aged <5 years and the single-most important cause of death in the first month of life. Research examining determinants of preterm birth in Ethiopia is limited. Therefore, this study aimed to determine risk factors associated with preterm births at Jimma University Medical Center in southwest Ethiopia. Methods: This unmatched case-control study was conducted from March 15 to April 1, 2017 from medical records of mothers and newborns delivered at Jimma University Medical Center from January 1 to December 30, 2016...
2018: Pediatric Health, Medicine and Therapeutics
Caroline Diguisto, Laurence Foix L'Helias, Andrei S Morgan, Pierre-Yves Ancel, Gilles Kayem, Monique Kaminski, Franck Perrotin, Babak Khoshnood, Francois Goffinet
OBJECTIVE: To evaluate the association between active antenatal management and neonatal outcomes in extremely preterm newborns admitted to a neonatal intensive care unit (NICU). STUDY DESIGN: This population-based cohort study was conducted in 25 regions of France. Infants born in 2011 between 220/7 and 266/7 weeks of gestation and admitted to a NICU were included. Infants with lethal congenital malformations or death in the delivery room were excluded. A multilevel multivariable analysis was performed, accounting for clustering by mother (multiple pregnancies) and hospital plus individual characteristics, to estimate the association between the main exposure of no active antenatal management (not receiving antenatal corticosteroids, magnesium sulfate, or cesarean delivery for fetal indications) and a composite outcome of death or severe neonatal morbidity (including severe forms of brain or lung injury, retinopathy of prematurity, and necrotizing enterocolitis)...
September 27, 2018: Journal of Pediatrics
Linda Van Horn, Alan Peaceman, Mary Kwasny, Eileen Vincent, Angela Fought, Jami Josefson, Bonnie Spring, Lisa M Neff, Niki Gernhofer
INTRODUCTION: Technology-enhanced antenatal diet and lifestyle intervention could prevent excess gestational weight gain and benefit mother and child. STUDY DESIGN: A randomized clinical trial. SETTING/PARTICIPANTS: Overweight and obese ethnically diverse pregnant women in Chicago, Illinois, were enrolled between October 2012 and December 2015, with antenatal data collection completed by July 2016. Analysis was completed June 2017. INTERVENTION: Participants were randomized when their fetus was gestational age 16 weeks to dietitian-led Dietary Approaches to Stop Hypertension diet and physical activity coaching that was received as three individual and six group counseling sessions by phone and webinar...
September 14, 2018: American Journal of Preventive Medicine
A J Solaz-García, L Segovia-Navarro, J L Rodríguez de Dios-Benlloch, L Benavent-Taengua, D Y Castilla-Rodríguez, M A Company-Morenza
INTRODUCTION: Delayed meconium expulsion is a cause of bowel obstruction in the extremely premature newborn (<28 WGE) weighing less than 1500g at birth. OBJECTIVE: To evaluate the efficacy of conservative treatment in the prevention of meconium obstruction in very-low-birt- weight preterm infants. METHOD: Descriptive and retrospective study performed at the Neonatal Intensive Care Unit of a tertiary level hospital. All very-low-birth-weight preterm infants who were born during the study period, from August 2016 to January 2017, and who had meconium obstruction were included...
September 20, 2018: Enfermería Intensiva
Chenxia Juan, Qian Wang, Yan Mao, Qian Cao, Sheng Li, Chunmin Qiao, Daoqi Zhang, Guoping Zhou
Neonatal respiratory distress syndrome (NRDS) is a leading cause of morbidity in premature newborns and is a common reason for admission to the neonatal intensive care unit (NICU). Recent studies found that the pathogenesis of NRDS is not simply lung immaturity. Apoptosis is an essential process for the development and maturation of the lungs. In this study, we report a critical role of lncRNA MALAT1 in regulating CD80 transcription in the NRDS-associated apoptosis via binding with NF-κB. We first showed MALAT1 and CD80 were highly expressed in the peripheral blood mononuclear cells of NRDS with infection exposure...
September 19, 2018: International Journal of Biochemistry & Cell Biology
Annemarie Stroustrup, Jennifer B Bragg, Stefanie A Busgang, Syam S Andra, Paul Curtin, Emily A Spear, Allan C Just, Manish Arora, Chris Gennings
In the United States each year, more than 300,000 infants are admitted to neonatal intensive care units (NICU) where they are exposed to a chemical-intensive hospital environment during a developmentally vulnerable period. Although multiple studies have demonstrated elevated phthalate biomarkers in NICU patients, specific sources of NICU-based phthalate exposure have not been identified.In this study, premature newborns with birth weight <1500 g were recruited to participate in a prospective environmental health cohort during the NICU hospitalization...
September 21, 2018: Journal of Exposure Science & Environmental Epidemiology
Avneet K Mangat, Ju-Lee Oei, Kerry Chen, Im Quah-Smith, Georg M Schmölzer
Pain is a major problem in sick newborn infants, especially for those needing intensive care. Pharmacological pain relief is the most commonly used, but might be ineffective and has side effects, including long-term neurodevelopmental sequelae. The effectiveness and safety of alternative analgesic methods are ambiguous. The objective was to review the effectiveness and safety of non-pharmacological methods of pain relief in newborn infants and to identify those that are the most effective. PubMed and Google Scholar were searched using the terms: "infant", "premature", "pain", "acupuncture", "skin-to-skin contact", "sucrose", "massage", "musical therapy" and 'breastfeeding'...
September 20, 2018: Children
Maria J O Miele, Rodolfo C Pacagnella, Maria J D Osis, Carina R Angelini, Jussara L Souza, José G Cecatti
BACKGROUND: The principal aim of this study was to understand how communication between parents and health professionals concerning prematurity occurs, from delivery to admission to the neonatal Intensive Care Unit. METHODS: This is an exploratory, descriptive study with a qualitative methodology. Data were collected using tape-recorded and Focal Groups technique interview with mothers of premature newborns and health professionals involved in caring for preterm infants, at southeast Brazil...
September 12, 2018: Reproductive Health
Angela Grassi, Giada Sgherri, Olena Chorna, Viviana Marchi, Luigi Gagliardi, Francesca Cecchi, Cecilia Laschi, Andrea Guzzetta
BACKGROUND: Premature birth is associated with feeding difficulties due to inadequate coordination of sucking, swallowing, and breathing. Nonnutritive sucking (NNS) and oral stimulation interventions may be effective for oral feeding promotion, but the mechanisms of the intervention effects need further clarifications. PURPOSE: We reviewed preterm infant intervention studies with quantitative outcomes of sucking performance to summarize the evidence of the effect of interventions on specific components of sucking...
September 7, 2018: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
Laura A Wang, P Brian Smith, Matthew Laughon, Ronald N Goldberg, Lawrence C Ku, Kanecia O Zimmerman, Stephen Balevic, Reese H Clark, Daniel K Benjamin, Rachel G Greenberg
BACKGROUND: At very high doses, furosemide is linked to ototoxicity in adults, but little is known about the risk of hearing loss in premature infants exposed to furosemide. AIMS: Evaluate the association between prolonged furosemide exposure and abnormal hearing screening in premature infants. STUDY DESIGN: Using propensity scoring, infants with prolonged (≥28 days) exposure to furosemide were matched to infants never exposed. The matched sample was used to estimate the impact of prolonged furosemide exposure on the probability of an abnormal hearing screen prior to hospital discharge...
October 2018: Early Human Development
Désirée Díaz-Jiménez, María de Las Nieves Cano Lara, María García-Mauricio Pereira
We present a clinical case of a premature birth from a mother of 33+5 weeks gestation where the newborn was admitted to the neonatal unit due to her low weight, chest retraction and prematurity, despite an Apgar score of 8/9/10 and birth weight of 1.300 g. The team of midwives that attended the woman from her arrival performed an assessment according to Virginia Henderson's Needs. Nursing diagnoses for the mother of Situational low self- esteem and Deficient Knowledge were established, and of Ineffective thermoregulation for the newborn infant...
September 2018: Enfermería Clínica
A A Eduard Verhagen
An examination of the policies regarding the care of extremely premature newborns reveals unexpected differences between Scandinavian countries and the Netherlands. Three topics related to decision-making at the beginning and at the end of life are identified and discussed.
September 2018: Pediatrics
Maria Lorella Gianni, Elena Nicoletta Bezze, Patrizio Sannino, Michela Baro, Paola Roggero, Salvatore Muscolo, Laura Plevani, Fabio Mosca
BACKGROUND: The supply of breast milk to preterm infants tends to occur at a lower rate than that recorded among term infants. We aimed to investigate the facilitators of and barriers to breastfeeding during hospital stay according to the experiences of mothers that gave birth to premature infants requiring admission to neonatal intensive care unit. METHODS: A cross-sectional questionnaire survey was conducted. Mothers who had delivered a newborn with a gestational age ≤33 weeks requiring intensive care, entered the study...
August 27, 2018: BMC Pediatrics
Josephine Johnston, John D Lantos, Aaron Goldenberg, Flavia Chen, Erik Parens, Barbara A Koenig
Many scientists and doctors hope that affordable genome sequencing will lead to more personalized medical care and improve public health in ways that will benefit children, families, and society more broadly. One hope in particular is that all newborns could be sequenced at birth, thereby setting the stage for a lifetime of medical care and self-directed preventive actions tailored to each child's genome. Indeed, commentators often suggest that universal genome sequencing is inevitable. Such optimism can come with the presumption that discussing the potential limits, cost, and downsides of widespread application of genomic technologies is pointless, excessively pessimistic, or overly cautious...
July 2018: Hastings Center Report
Barbara Prediger, Stephanie Polus, Tim Mathes, Stefanie Bühn, Frank Louwen, Edmund A M Neugebauer, Dawid Pieper
BACKGROUND: The rate of caesarean sections increased in the last decades to about 30% of births in western populations. Many caesarean sections are electively planned without an urgent medical reason for mother or child. Especially in women with a foregoing caesarean section, the procedure is planned early. An early caesarean section though may harm the newborn. Our aim is to evaluate the gestational time point after the 37th gestational week (after prematurity = term) of performing an elective caesarean section with the lowest morbidity for mother and child...
August 16, 2018: Systematic Reviews
Girma Temam Shifa, Ahmed Ali Ahmed, Alemayehu Worku Yalew
BACKGROUND: Though Ethiopia has shown a considerable improvement in reducing under-five mortality rate since 1990, many children still continue to die prematurely. Mixed results have been reported about determinants of under-five mortality. Besides, there is paucity of mortality studies in the current study site. Therefore, this study was conducted to assess maternal and child health related predictors of under-five mortality in Southern Ethiopia. METHODS: A matched case control study was conducted in 2014 in Arba Minch Town and Arba Minch Zuria District of Gamo Gofa Zone, Southern Ethiopia...
2018: PloS One
Camila Padovani, Rosana Rosseto de Oliveira, Sandra Marisa Pelloso
OBJECTIVE: To analyze the prevalence of syphilis in during pregnancy and its association with socioeconomic characteristics, reproductive history, prenatal and labor care, and newborn characteristics. METHOD: A retrospective, cross-sectional study based on gestational and congenital syphilis reports. A (records) linkage was performed in the Brazilian databases: "Information System for Notifiable Diseases" (Sistema de Informação de Agravos de Notificação - SINAN); "Live Births Information System" (Sistema de Informação sobre Nascidos Vivos - SINASC); and "Mortality Information System" (Sistema de Informação sobre Mortalidade - SIM)...
August 9, 2018: Revista Latino-americana de Enfermagem
Benjamin Anathory Kamala, Andrew Hans Mgaya, Matilda Michael Ngarina, Hussein Lesio Kidanto
Introduction: The global prevalence of low birth weight (LBW) is 16%, representing more than 20 million infants worldwide, of which 96% are born in low-income countries. This study aimed to determine the prevalence, predictors and perinatal outcomes of LBW newborns. Methods: We conducted a retrospective analysis of data obtained from the hospital's obstetric and neonatal database. Descriptive statistics and multivariate logistic regression were performed with 95% confidence intervals (CI)...
2018: Pan African Medical Journal
Emily L Johnson, Anne E Burke, Anqi Wang, Page B Pennell
OBJECTIVE: To compare the proportions of unintended pregnancies, prenatal vitamin or folic acid (PNVF) use, adequate prenatal care visits, and breastfeeding among women with epilepsy (WWE) to women without epilepsy (WWoE). METHODS: The Pregnancy Risk Assessment Monitoring System (PRAMS) is an annual survey of randomly sampled postpartum women administered by the Centers for Disease Control and Prevention. We used PRAMS data from 13 states from 2009 to 2014 to compare the primary outcomes in WWE and WWoE, as well as our secondary outcomes of contraception practices, newborn outcomes, and time to recognition of pregnancy...
September 11, 2018: Neurology
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