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Alexandra M Preisser, Rosalie V McDonough, Volker Harth
PURPOSE: Workers on offshore wind turbine installations face a variety of physical and psychological challenges. To prevent potentially dangerous situations or incidents, guidelines for the physical aptitude testing of offshore employees in Germany and other European countries have been developed. However, these criteria have not been previously empirically tested for validity. Although an important component of occupational health and safety, such aptitude testing should not lead to the unjustified exclusion of potential employees...
December 1, 2018: International Archives of Occupational and Environmental Health
Rosalie Corona, Kristina B Hood, Firoza Haffejee
HIV continues to be a health priority in South Africa. Consistent condom use helps prevent HIV, yet less than half of South African emerging adults use condoms consistently. Cultural beliefs about illnesses (e.g., being thin is perceived to be a sign of HIV infection) suggest that body image perceptions may play a role in emerging adults' condom use outcomes. We explored the relationships between body image perceptions (i.e., body dissatisfaction, body consciousness) and condom use outcomes (e.g., attitudes, negotiation efficacy, past use) in a sample of South African emerging adults...
November 30, 2018: Prevention Science: the Official Journal of the Society for Prevention Research
Susanne Steinbrecht, Rosalie König, Kai-Uwe Schmidtke, Natalie Herzog, Katrin Scheibner, Anne Krüger-Genge, Friedrich Jung, Sarah Kammerer, Jan-Heiner Küpper
Preclinical drug safety assessment includes in vitro studies with physiologically relevant cell cultures. As an in vitro system for hepatic toxicology testing, we have been generating cell clones of human hepatoma cell line HepG2 by lentiviral transduction of phase I cytochrome P450 (CYP) enzymes. Here, we present a stable CYP2C19-overexpressing HepG2 cell clone (HepG2-2C19 C1) showing an enzyme activity of approximately 82 pmol x min-1 x mg-1 total cellular protein. The phenotypic stability over several passages of HepG2-2C19 C1 renders them to be a suitable reference cell clone for benchmarking CYP2C19 enzyme activity...
November 27, 2018: Toxicology
Carole Kenner, Kristin Ashford, Lina Kurdahi Badr, Beth Black, Joan Bloch, Rosalie Mainous, Jacqueline McGrath, Shahirose Premji, Susan Sinclair, Mary Terhaar, M Terese Verklan, Marlene Walden, Deborah S Walker, Rosemary White-Traut, SeonAe Yeo, Linda B Zekas, Elizabeth A Kostas-Polston, Cindy Smith Greenberg, Marina Boykova
No abstract text is available yet for this article.
September 2018: Nursing Outlook
Linzhou Zhuang, Yi Jia, Hongli Liu, Xin Wang, Rosalie K Hocking, Hongwei Liu, Jun Chen, Lei Ge, Longzhou Zhang, Mengran Li, Chung-Li Dong, Yu-Cheng Huang, Shaohua Shen, Dongjiang Yang, Zhonghua Zhu, Xiangdong Yao
Rational design and synthesis of hetero-coordinated moieties at the atomic scale can significantly raise the performance of the catalyst and obtain mechanistic insight into the oxygen-involving electrocatalysis. Here, a facile plasma-photochemical strategy is applied to construct atomically coordinated Pt-Co-Se moieties in defective CoSe2 (CoSe2- x ) through filling the plasma-created Se vacancies in CoSe2- x with single Pt atomic species (CoSe2- x -Pt) under ultraviolet irradiation. The filling of single Pt can remarkably enhance the oxygen evolution reaction (OER) activity of CoSe2 ...
November 28, 2018: Advanced Materials
Cathalijn H C Leenaars, Jennifer Freymann, Koen Jakobs, Julia M L Menon, Thomas J Van Ee, Janneke Elzinga, Rosalie W M Kempkes, Bea Zoer, Pim W H I M Drinkenburg
Background: Microdialysis can be used to measure amino acids in the extracellular space in vivo, based on the principle of diffusion. Variations in experimental set-up result in variations in baseline levels of the compounds measured. Variations may also be due to circadian rhythms. Method: We systematically searched and mapped the literature on all studies reporting baseline microdialysis measurements of histamine and the amino acids asparagine, aspartate, GABA, glutamate, glutamine, glycine, proline and taurine...
October 9, 2018: Journal of Circadian Rhythms
Sebastian Rühl, Kateryna Shkarina, Benjamin Demarco, Rosalie Heilig, José Carlos Santos, Petr Broz
Pyroptosis is a lytic form of cell death that is induced by inflammatory caspases upon activation of the canonical or noncanonical inflammasome pathways. These caspases cleave gasdermin D (GSDMD) to generate an N-terminal GSDMD fragment, which executes pyroptosis by forming membrane pores. We found that calcium influx through GSDMD pores serves as a signal for cells to initiate membrane repair by recruiting the endosomal sorting complexes required for transport (ESCRT) machinery to damaged membrane areas, such as the plasma membrane...
November 23, 2018: Science
Rosalie M Sterner, Reona Sakemura, Michelle J Cox, Nan Yang, Roman H Khadka, Cynthia L Forsman, Michael J Hansen, Fang Jin, Katayoun Ayasoufi, Mehrdad Hefazi, Kendall J Schick, Denise K Walters, Omar Ahmed, Dale Chappell, Tarek Sahmoud, Cameron Durrant, Wendy K Nevala, Mrinal M Patnaik, Larry Pease, Karen E Hedin, Neil E Kay, Aaron J Johnson, Saad S Kenderian
Chimeric antigen receptor T (CAR-T) cell therapy is a new pillar in cancer therapeutics; however, its application is limited by the associated toxicities. These include cytokine release syndrome (CRS) and neurotoxicity. While the IL-6R antagonist tocilizumab is approved for treatment of CRS, there is no approved treatment of neurotoxicity associated with CD19 targeted CAR-T (CART19) cell therapy. Recent data suggest that monocytes and macrophages contribute to the development of CRS and neurotoxicity after CAR-T cell therapy...
November 21, 2018: Blood
François Michaud, Ning Li, Rosalie Plantefève, Zeynab Nosrati, Charles Tremblay, Katayoun Saatchi, Gerald Moran, Alexandre Bigot, Urs O Häfeli, Samuel Kadoury, An Tang, Pierre Perreault, Sylvain Martel, Gilles Soulez
PURPOSE: To demonstrate the feasibility of using a custom gradient sequence on an unmodified 3T magnetic resonance imaging (MRI) scanner to perform magnetic resonance navigation (MRN) by investigating the blood flow control method in vivo, reproducing the obtained rheology in a phantom mimicking porcine hepatic arterial anatomy, injecting magnetized microbead aggregates through an implantable catheter, and steering the aggregates across arterial bifurcations for selective tumor embolization...
November 19, 2018: Medical Physics
Rosalie Nguyen, Nikolaos Soldatos, Duong Tran, Popi Stylianou, Nikola Angelov, Robin Weltman
PURPOSE: The rate of dental implant failures ranges from 3% to 8%, with that number increasing as the number of implants placed increases. When an implant fails, the survival rate drops significantly when a second or third attempt is performed. The aim of this study was to evaluate the survival rate of an implant placed in a previously failed implant site and to explore the risk factors that might affect the outcome of the second procedure. MATERIALS AND METHODS: A retrospective chart review was conducted for patients receiving dental implants at the University of Texas, School of Dentistry from 1985 to 2017...
November 2018: International Journal of Oral & Maxillofacial Implants
Péricles Maranhão-Filho, Rosalie Branco Correa
Recognizing the semiologic importance of the second, and most famous, sign described by Joseph Babinski - the extension of the hallux after stimulation of the plantar region in order to differentiate organic from pithiatic paralysis- several authors have tried to find a comparable signal in the hand. After 122 years, no one has succeeded.
October 2018: Arquivos de Neuro-psiquiatria
Lisa R Hoving, Saeed Katiraei, Amanda Pronk, Marieke Heijink, Kelly K D Vonk, Fatiha Amghar-El Bouazzaoui, Rosalie Vermeulen, Lizette Drinkwaard, Martin Giera, Vanessa van Harmelen, Ko Willems van Dijk
Gut microbiota have been implicated in the development of atherosclerosis and cardiovascular disease. Since the prebiotic inulin is thought to beneficially affect gut microbiota, we aimed to determine the effect of inulin supplementation on atherosclerosis development in APOE*3-Leiden.CETP (E3L.CETP) mice. Female E3L.CETP mice were fed a western-type diet containing 0.1% or 0.5% cholesterol with or without 10% inulin. The effects of inulin were determined on: microbiota composition, cecal short-chain fatty acid (SCFA) levels, plasma lipid levels, atherosclerosis development, hepatic morphology and hepatic inflammation...
November 8, 2018: Scientific Reports
Rosalie Lubbers, Jayne S Sutherland, Delia Goletti, Roelof A de Paus, Coline H M van Moorsel, Marcel Veltkamp, Stefan M T Vestjens, Willem J W Bos, Linda Petrone, Franca Del Nonno, Ingeborg M Bajema, Karin Dijkman, Frank A W Verreck, Gerhard Walzl, Kyra A Gelderman, Geert H Groeneveld, Annemieke Geluk, Tom H M Ottenhoff, Simone A Joosten, Leendert A Trouw
Background: Tuberculosis (TB) remains a major threat to global health. Currently, diagnosis of active TB is hampered by the lack of specific biomarkers that discriminate active TB disease from other (lung) diseases or latent TB infection (LTBI). Integrated human gene expression results have shown that genes encoding complement components, in particular different C1q chains, were expressed at higher levels in active TB compared to LTBI. Methods: C1q protein levels were determined using ELISA in sera from patients, from geographically distinct populations, with active TB, LTBI as well as disease controls...
2018: Frontiers in Immunology
Phyllis Butow, Joanne Shaw, Heather L Shepherd, Melanie Price, Lindy Masya, Brian Kelly, Nicole M Rankin, Afaf Girgis, Thomas F Hack, Philip Beale, Rosalie Viney, Haryana M Dhillon, Joseph Coll, Patrick Kelly, Melanie Lovell, Peter Grimison, Tim Shaw, Tim Luckett, Jessica Cuddy, Fiona White
BACKGROUND: Health service change is difficult to achieve. One strategy to facilitate such change is the clinical pathway, a guide for clinicians containing a defined set of evidence-based interventions for a specific condition. However, optimal strategies for implementing clinical pathways are not well understood. Building on a strong evidence-base, the Psycho-Oncology Co-operative Research Group (PoCoG) in Australia developed an evidence and consensus-based clinical pathway for screening, assessing and managing cancer-related anxiety and depression (ADAPT CP) and web-based resources to support it - staff training, patient education, cognitive-behavioural therapy and a management system (ADAPT Portal)...
November 7, 2018: BMC Cancer
Nigel Pereira, Isaac Kligman, Rosalie Hunt, Rohini Kopparam, Bridget Wahmann, Zev Rosenwaks
We report a case of fertility preservation using random-start controlled ovarian stimulation (COS), intracytoplasmic sperm injection (ICSI) and embryo cryopreservation in a patient with early pregnancy-associated breast cancer. A 34-year-old nulliparous woman at 5 weeks of gestation was diagnosed with estrogen receptor (ER) positive, progesterone receptor (PR) positive and human epidermal growth factor receptor-2 (HER-2) negative infiltrating intraductal carcinoma. Urgent neoadjuvant chemotherapy was deemed necessary and the patient decided to terminate the pregnancy...
November 7, 2018: Gynecological Endocrinology
Christine Amisi, Rosalie Biaba Apassa, Aline Cikara, Gudrun Østby, Ragnhild Nordås, Siri Aas Rustad, John Quattrochi
In the eastern Democratic Republic of the Congo there are several support programmes for sexual violence survivors, but their impacts are rarely systematically assessed. We investigated the effects for women from two support programmes that include both survivors of sexual and gender-based violence (SGBV) and others. Specifically, we estimated (1) the effect of SGBV on social exclusion and economic well-being, and (2) the effects of support programmes on social exclusion and economic well-being, as well as differential effects for SGBV survivors and others...
November 7, 2018: Medicine, Conflict, and Survival
Becka Wagner, Cindra Holland, Rosalie Mainous, William Matcham, Gengxin Li, Jessica Luiken
BACKGROUND: Incivility occurs in various forms in higher education and negatively affects teaching and learning outcomes. It has not been determined if incivility is more prevalent in one discipline than another. PURPOSE: The purpose of this study was to compare faculty and student perceptions of incivility across disciplines at a large public university. METHODS: In this descriptive comparative study, a convenience sample of 156 faculty and 421 students completed the Incivility in Higher Education-Revised survey electronically...
November 5, 2018: Nurse Educator
Pippa Oakeshott, Sarah Kerry-Barnard, Charlotte Fleming, Rachel Phillips, Vari M Drennan, Elisabeth J Adams, Wendy Majewska, Emma M Harding-Esch, Emma C Cousins, Tim Planche, Alastair Green, Rosalie I Bartholomew, S Tariq Sadiq, Fiona Reid
OBJECTIVES: We conducted a cluster-randomised feasibility trial of 90-minute Chlamydia trachomatis tests and same day on-site treatment ("Test n Treat/TnT") in six technical colleges in London, England to assess: • TnT uptake rates • Follow-up rates • Prevalence of C.trachomatis at baseline and 7-months • Time to treatment • Acceptability of TnT METHODS: Participants completed questionnaires and provided genitourinary samples at baseline and seven months. Participants were informed that baseline samples would not be tested for 7- months and advised to get screened independently...
October 31, 2018: Clinical Microbiology and Infection
Brittany L Allen-Petersen, Tyler Risom, Zipei Feng, Zhiping Wang, Zina P Jenny, Mary C Thoma, Katherine R Pelz, Jennifer P Morton, Owen J Sansom, Charles D Lopez, Brett Sheppard, Dale J Christensen, Michael Ohlmeyer, Goutham Narla, Rosalie C Sears
In cancer, kinases are often activated and phosphatases suppressed, leading to aberrant activation of signaling pathways driving cellular proliferation, survival, and therapeutic resistance. Although pancreatic ductal adenocarcinoma (PDA) has historically been refractory to kinase inhibition, therapeutic activation of phosphatases is emerging as a promising strategy to restore balance to these hyperactive signaling cascades. In the current study, we hypothesized that phosphatase activation combined with kinase inhibition could deplete oncogenic survival signals to reduce tumor growth...
November 2, 2018: Cancer Research
Adam J Rose, Justin W Timbie, Claude Setodji, Mark W Friedberg, Rosalie Malsberger, Katherine L Kahn
BACKGROUND: Regular primary care visits may allow an opportunity to deliver high-value, proactive care. However, no previous study has examined whether more temporally regular primary care visits predict better outcomes. OBJECTIVE: To examine the relationship between the temporal regularity of primary care (PC) visits and outcomes. DESIGN: Retrospective cohort study. PARTICIPANTS: We used Medicare claims for 378,862 fee-for-service Medicare beneficiaries, who received PC at 1328 federally qualified health centers from 2010 to 2014...
October 26, 2018: Journal of General Internal Medicine
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