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https://www.readbyqxmd.com/read/30319965/different-response-of-ptch-mutant-and-ptch-wildtype-rhabdomyosarcoma-toward-smo-and-pi3k-inhibitors
#1
Natalie Geyer, Rosalie Ridzewski, Julia Bauer, Maria Kuzyakova, Kai Dittmann, Christian Dullin, Albert Rosenberger, Hans-Ulrich Schildhaus, Anja Uhmann, Simone Fulda, Heidi Hahn
Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma with poor prognosis. RMS frequently show Hedgehog (HH) pathway activity, which is predominantly seen in the embryonal subtype (ERMS). They also show activation of Phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) signaling. Here we compared the therapeutic effectiveness and the impact on HH target gene expression of Smoothened (SMO) antagonists with those of the PI3K inhibitor pictilisib in ERMS with and without mutations in the HH receptor Patched1 ( PTCH )...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/30311017/australian-indigenous-land-management-ecological-knowledge-and-languages-for-conservation
#2
Rosalie Schultz, Tammy Abbott, Jessica Yamaguchi, Sheree Cairney
Many Indigenous Australians hold cultural, ecological and language knowledge, but common representations of Indigenous Australians focus on social disadvantage and poor comparisons with other Australians in education, employment and health. Indigenous Land Management works with Indigenous people's cultural, ecological and language expertise, employing Indigenous people in activities contributing to biodiversity conservation. The Interplay research surveyed 841 Indigenous people in remote communities. Those employed in land management reported greater participation in cultural activities, language knowledge, and belief that their land was looked after...
October 11, 2018: EcoHealth
https://www.readbyqxmd.com/read/30309309/absolute-cardiovascular-disease-risk-and-lipid-lowering-therapy-among-aboriginal-and-torres-strait-islander-australians
#3
Rosalie Schultz
No abstract text is available yet for this article.
October 15, 2018: Medical Journal of Australia
https://www.readbyqxmd.com/read/30305424/sumo-protease-senp1-desumoylates-and-stabilizes-c-myc
#4
Xiao-Xin Sun, Yingxiao Chen, Yulong Su, Xiaoyan Wang, Krishna Mohan Chauhan, Juan Liang, Colin J Daniel, Rosalie C Sears, Mu-Shui Dai
Posttranslational modifications play a crucial role in the proper control of c-Myc protein stability and activity. c-Myc can be modified by small ubiquitin-like modifier (SUMO). However, how SUMOylation regulates c-Myc stability and activity remains to be elucidated. The deSUMOylation enzyme, SENP1, has recently been shown to have a prooncogenic role in cancer; however, mechanistic understanding of this is limited. Here we show that SENP1 is a c-Myc deSUMOylating enzyme. SENP1 interacts with and deSUMOylates c-Myc in cells and in vitro...
October 10, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/30292451/outcomes-of-vital-pulp-therapy-using-mineral-trioxide-aggregate-or-biodentine-a-prospective-randomized-clinical-trial
#5
Lama Awawdeh, Aladdin Al-Qudah, Hanan Hamouri, Rosalie Jean Chakra
INTRODUCTION: Mineral trioxide aggregate (MTA) has been used in pulp capping of cariously exposed mature permanent teeth with promising results. The search for alternative materials that seal better and set faster than MTA and do not stain is ongoing. Biodentine (Septodont, St Maur-des-Fossés, France) exhibits these advantages but has not been tested yet for a prolonged duration in mature teeth. This study aimed to evaluate the clinical performance of Biodentine and white MTA (Angelus, Londrina, Brazil) in cariously exposed mature permanent teeth...
October 3, 2018: Journal of Endodontics
https://www.readbyqxmd.com/read/30289360/effects-of-generalization-of-engagement-in-parkour-from-physical-education-to-recess-on-physical-activity
#6
Rosalie Coolkens, Phillip Ward, Jan Seghers, Peter Iserbyt
PURPOSE: To investigate the effect of generalization of engagement in parkour from physical education (PE) to organized and supervised recess on voluntary participation and moderate-to-vigorous physical activity (MVPA). METHOD: Children received a 6-day parkour unit in PE and every two lessons they could voluntarily participate in 20-min parkour recess. Fourteen elementary school classes constituting 281 children (8-10 years old) and 16 PE teachers were randomized to either three supervised or three organized parkour recess sessions...
October 5, 2018: Research Quarterly for Exercise and Sport
https://www.readbyqxmd.com/read/30281733/decidix-meeting-of-the-paulo-freire-pedagogy-with-the-serious-games-in-the-field-of-health-education-with-adolescents
#7
Rosana Juliet Silva Monteiro, Marcela Paula Conceição de Andrade Oliveira, Rosalie Barreto Belian, Luciane Soares de Lima, Maria Eliete Santiago, Daniela Tavares Gontijo
INTRODUCTION: Health education with adolescents is a challenge. Serious games are considered strategic tools, and their effectiveness is related to the pedagogical model adopted. Health education can promote leadership and autonomy, especially since is based on Paulo Freire's Pedagogy as the theoretical foundation. OBJECTIVE: To analyze the contributions of the DECIDIX serious game for educational purposes, supported by Paulo Freire's foundations, applied to health education with adolescents in the sexual and reproductive field...
September 2018: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/30270109/automated-design-of-efficient-and-functionally-diverse-enzyme-repertoires
#8
Olga Khersonsky, Rosalie Lipsh, Ziv Avizemer, Yacov Ashani, Moshe Goldsmith, Haim Leader, Orly Dym, Shelly Rogotner, Devin L Trudeau, Jaime Prilusky, Pep Amengual-Rigo, Victor Guallar, Dan S Tawfik, Sarel J Fleishman
Substantial improvements in enzyme activity demand multiple mutations at spatially proximal positions in the active site. Such mutations, however, often exhibit unpredictable epistatic (non-additive) effects on activity. Here we describe FuncLib, an automated method for designing multipoint mutations at enzyme active sites using phylogenetic analysis and Rosetta design calculations. We applied FuncLib to two unrelated enzymes, a phosphotriesterase and an acetyl-CoA synthetase. All designs were active, and most showed activity profiles that significantly differed from the wild-type and from one another...
October 4, 2018: Molecular Cell
https://www.readbyqxmd.com/read/30253879/thin-composite-wire-strut-durable-polymer-coated-resolute-onyx-versus-ultrathin-cobalt-chromium-strut-bioresorbable-polymer-coated-orsiro-drug-eluting-stents-in-allcomers-with-coronary-artery-disease-bionyx-an-international-single-blind-randomised-non-inferiority
#9
Clemens von Birgelen, Paolo Zocca, Rosaly A Buiten, Gillian A J Jessurun, Carl E Schotborgh, Ariel Roguin, Peter W Danse, Edouard Benit, Adel Aminian, K Gert van Houwelingen, Rutger L Anthonio, Martin G Stoel, Samer Somi, Marc Hartmann, Gerard C M Linssen, Carine J M Doggen, Marlies M Kok
BACKGROUND: During the past decade, many patients had zotarolimus-eluting stents implanted, which had circular shape cobalt-chromium struts with limited radiographic visibility. The Resolute Onyx stent was developed to improve visibility while reducing strut thickness, which was achieved by using a novel composite wire with a dense platinum-iridium core and an outer cobalt-chromium layer. We did the first randomised clinical trial to assess the safety and efficacy of this often-used stent compared with the Orsiro stent, which consists of ultrathin cobalt-chromium struts...
September 21, 2018: Lancet
https://www.readbyqxmd.com/read/30246132/an-atypical-case-of-papular-necrobiosis-lipoidica-masquerading-as-sarcoidosis
#10
David A Hashemi, Caroline A Nelson, Rosalie Elenitsas, Misha Rosenbach
No abstract text is available yet for this article.
September 2018: JAAD Case Reports
https://www.readbyqxmd.com/read/30234022/mobilizable-plasmids-for-tunable-gene-expression-in-francisella-novicida
#11
Maj Brodmann, Rosalie Heilig, Petr Broz, Marek Basler
Francisella tularensis is the causative agent of the life-threatening disease tularemia. However, the molecular tools to study Francisella are limited. Especially, expression plasmids are sparse and difficult to use, as they are unstable and prone to spontaneous loss. Most Francisella expression plasmids lack inducible promoters making it difficult to control gene expression levels. In addition, available expression plasmids are mainly designed for F. tularensis , however, genetic differences including restriction-modification systems impede the use of these plasmids in F...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/30232459/differentiation-state-plasticity-is-a-targetable-resistance-mechanism-in-basal-like-breast-cancer
#12
Tyler Risom, Ellen M Langer, Margaret P Chapman, Juha Rantala, Andrew J Fields, Christopher Boniface, Mariano J Alvarez, Nicholas D Kendsersky, Carl R Pelz, Katherine Johnson-Camacho, Lacey E Dobrolecki, Koei Chin, Anil J Aswani, Nicholas J Wang, Andrea Califano, Michael T Lewis, Claire J Tomlin, Paul T Spellman, Andrew Adey, Joe W Gray, Rosalie C Sears
Intratumoral heterogeneity in cancers arises from genomic instability and epigenomic plasticity and is associated with resistance to cytotoxic and targeted therapies. We show here that cell-state heterogeneity, defined by differentiation-state marker expression, is high in triple-negative and basal-like breast cancer subtypes, and that drug tolerant persister (DTP) cell populations with altered marker expression emerge during treatment with a wide range of pathway-targeted therapeutic compounds. We show that MEK and PI3K/mTOR inhibitor-driven DTP states arise through distinct cell-state transitions rather than by Darwinian selection of preexisting subpopulations, and that these transitions involve dynamic remodeling of open chromatin architecture...
September 19, 2018: Nature Communications
https://www.readbyqxmd.com/read/30228977/a-statewide-model-for-assisting-nursing-home-residents-to-transition-successfully-to-the-community
#13
Darci Buttke, Valerie Cooke, Kathleen Abrahamson, Tetyana Shippee, Heather Davila, Rosalie Kane, Greg Arling
Minnesota's Return to Community Initiative (RTCI) is a novel, statewide initiative to assist private paying nursing home residents to return to the community and to remain in that setting without converting to Medicaid. The objective of this manuscript is to describe in detail RTCI's development and design, its key operational components, and characteristics of its clients and their care outcomes. Data on client characteristics and outcomes come from the Minimum Data Set, staff assessments of clients and caregivers, and Medicaid eligibility files...
June 2018: Geriatrics
https://www.readbyqxmd.com/read/30218046/the-gut-microbiota-promotes-hepatic-fatty-acid-desaturation-and-elongation-in-mice
#14
Alida Kindt, Gerhard Liebisch, Thomas Clavel, Dirk Haller, Gabriele Hörmannsperger, Hongsup Yoon, Daniela Kolmeder, Alexander Sigruener, Sabrina Krautbauer, Claudine Seeliger, Alexandra Ganzha, Sabine Schweizer, Rosalie Morisset, Till Strowig, Hannelore Daniel, Dominic Helm, Bernhard Küster, Jan Krumsiek, Josef Ecker
Interactions between the gut microbial ecosystem and host lipid homeostasis are highly relevant to host physiology and metabolic diseases. We present a comprehensive multi-omics view of the effect of intestinal microbial colonization on hepatic lipid metabolism, integrating transcriptomic, proteomic, phosphoproteomic, and lipidomic analyses of liver and plasma samples from germfree and specific pathogen-free mice. Microbes induce monounsaturated fatty acid generation by stearoyl-CoA desaturase 1 and polyunsaturated fatty acid elongation by fatty acid elongase 5, leading to significant alterations in glycerophospholipid acyl-chain profiles...
September 14, 2018: Nature Communications
https://www.readbyqxmd.com/read/30216138/the-effect-of-organized-versus-supervised-recess-on-elementary-school-children-s-participation-physical-activity-play-and-social-behavior-a-cluster-randomized-controlled-trial
#15
Rosalie Coolkens, Phillip Ward, Jan Seghers, Peter Iserbyt
BACKGROUND: Recess strategies that increase children's physical activity and contribute to the daily 60 minutes of moderate to vigorous physical activity (MVPA) are recommended. METHODS: A cluster randomized trial was conducted to examine the effect of supervised versus organized recess on children's participation, physical activity, play, and social behavior. In supervised recess, children were free to play, and physical education (PE) teachers ensured safety. In organized recess, PE teachers provided challenging tasks...
October 1, 2018: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/30215202/circulating-leptin-and-branched-chain-amino-acids-correlation-with-intraductal-papillary-mucinous-neoplasm-dysplastic-grade
#16
Michele T Yip-Schneider, Rachel Simpson, Rosalie A Carr, Huangbing Wu, Hao Fan, Ziyue Liu, Murray Korc, Jianjun Zhang, C Max Schmidt
BACKGROUND: The most common type of mucinous pancreatic cyst that may progress to pancreatic cancer is intraductal papillary mucinous neoplasm (IPMN). Low-risk IPMN with low-/moderate-grade dysplasia may be safely watched, whereas high-risk IPMN with high-grade dysplasia or invasive components should undergo resection. However, there is currently no reliable means of making this distinction. We hypothesize that blood concentrations of insulin resistance biomarkers may aid in the differentiation of low- and high-risk IPMN...
September 13, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/30196257/effect-of-halo-type-frontal-cockpit-protection-on-overtaking
#17
Simon M Rosalie, James M Malone
In 2018, the Fédération Internationale de l'Automobile introduced the halo frontal cockpit protection system into Formula 1. While extensive testing was conducted to confirm that the halo protects the driver from contact, the halo's effect on the driver during overtaking was not tested prior to its introduction. Here, we describe the effect of a halo-type structure on the neck muscle activity of one of the authors, a national-level amateur racing driver, during on-track simulations designed to practise overtaking...
September 8, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/30194697/enhanced-interdisciplinary-communication-development-of-an-interactive-thyroid-nodule-cancer-disease-map
#18
Sami P Moubayed, Rosalie Machado, R Michael Tuttle, Lisa A Orloff, Gregory Randolph, Juan C Hernandez-Prera, Martha J Griffin, Mark L Urken
OBJECTIVES: Deficits related to inadequate clinical communication can result in incorrect diagnoses, inappropriate surgery, incorrect disease stratification, pathologic reporting, and/or interpretation. There are currently no validated or defined solutions to disease-specific communication with regard to thyroid care. METHODS: We propose a solution that could ameliorate problems arising from inadequate disease-specific communications between physicians through the development of a thyroid disease-specific database, the Thyroid Care Collaborative...
September 7, 2018: Laryngoscope
https://www.readbyqxmd.com/read/30194624/one-method-many-methodological-choices-a-structured-review-of-discrete-choice-experiments-for-health-state-valuation
#19
REVIEW
Brendan Mulhern, Richard Norman, Deborah J Street, Rosalie Viney
BACKGROUND: Discrete-choice experiments (DCEs) are used in the development of preference-based measure (PBM) value sets. There is considerable variation in the methodological approaches used to elicit preferences. OBJECTIVE: Our objective was to carry out a structured review of DCE methods used for health state valuation. METHODS: PubMed was searched until 31 May 2018 for published literature using DCEs for health state valuation. Search terms to describe DCEs, the process of valuation and preference-based instruments were developed...
September 8, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/30191658/rational-design-principles-for-the-transport-and-subcellular-distribution-of-nanomaterials-into-plant-protoplasts
#20
Tedrick Thomas Salim Lew, Min Hao Wong, Seon-Yeong Kwak, Rosalie Sinclair, Volodymyr B Koman, Michael S Strano
The ability to control the subcellular localization of nanoparticles within living plants offers unique advantages for targeted biomolecule delivery and enables important applications in plant bioengineering. However, the mechanism of nanoparticle transport past plant biological membranes is poorly understood. Here, a mechanistic study of nanoparticle cellular uptake into plant protoplasts is presented. An experimentally validated mathematical model of lipid exchange envelope penetration mechanism for protoplasts, which predicts that the subcellular distribution of nanoparticles in plant cells is dictated by the particle size and the magnitude of the zeta potential, is advanced...
September 6, 2018: Small
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