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Symmetrical AASI

Yurie Obata, Viachaslau Barodka, Dan E Berkowitz, Allan Gottschalk, Charles W Hogue, Jochen Steppan
BACKGROUND: Pulse pressure, the ambulatory arterial stiffness index (AASI), and the symmetric AASI are established predictors of adverse cardiovascular outcomes. However, little is known about their relationship to cerebral autoregulation. This study evaluated whether these markers of vascular properties relate to the lower limit of cerebral autoregulation (LLA). METHODS AND RESULTS: The LLA was determined during cardiac surgery with transcranial Doppler ultrasonography in 181 patients...
February 8, 2018: Journal of the American Heart Association
Marialberta Battocchio, Andrea Rebellato, Andrea Grillo, Francesca Dassie, Pietro Maffei, Stella Bernardi, Bruno Fabris, Renzo Carretta, Francesco Fallo
Long-standing exposure to endogenous cortisol excess is associated with high cardiovascular risk. The aim of our study was to investigate arterial stiffness, which has been recognized as an independent predictor of adverse cardiovascular outcome, in a group of patients with Cushing's syndrome. Twenty-four patients with Cushing's syndrome (3 males, mean age 49±13 years; 20 pituitary-dependent Cushing's disease and 4 adrenal adenoma) underwent 24-h ambulatory blood pressure monitoring (ABPM) and evaluation of cardiovascular risk factors...
March 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
Benjamin Gavish, Joseph L Izzo
Interest in arterial stiffness has been fueled by the scientific and clinical implications of its "vicious cycle" relationship with aging and systolic blood pressure. In physical terms, stiffness is the slope of the relationship between an artery's distending pressure and its cross-sectional area or volume. Pulse wave velocity (PWV, in m/s), the most common arterial stiffness indicator, is usually measured by the foot-to-foot time and distance method and is proportional to [stiffness × area (or volume)](1/2) at a given pressure...
July 12, 2016: American Journal of Hypertension
Minh B Nguyen, Pamela Singer, Fredrick Kaskel, Joseph Mahgerefteh
The ambulatory arterial stiffness index (AASI) and the symmetric ambulatory arterial stiffness index (s-AASI) have been shown to correlate to arterial stiffness in adults. This study assesses these indices with anthropometric and blood pressure (BP) measures in children. A total of 102 children at a pediatric hypertension clinic who had ambulatory blood pressure monitoring (ABPM) done from 2009 to 2013 were included (75% males, 7-22yo, 47% hypertensive, 24% prehypertensive, and 34% white-coat hypertensives)...
June 2016: Journal of the American Society of Hypertension: JASH
Malgorzata Wojcik, Jadwiga Malek, Dominika Janus, Kamil Fijorek
OBJECTIVE: There is increasing evidence for the contribution of obesity and its metabolic sequels in the development of arterial hypertension (AH). METHODS: The casual blood pressure (CBP), 24hABPM, ambulatory arterial stiffness index (AASI) and symmetric (sAASI) ambulatory arterial stiffness index (both derived from a 24 h ABPM) and selected laboratory tests were performed in 130 obese (mean BMI SDS 4.2) adolescents at the mean age of 13.7 years. RESULTS: AH was diagnosed in 36...
December 2015: Neuro Endocrinology Letters
Zhendong Liu, Jie Peng, Fanghong Lu, Yingxin Zhao, Shujian Wang, Shangwen Sun, Hua Zhang, Yutao Diao
The authors investigated effects of excessive salt intake and potassium supplementation on ambulatory arterial stiffness index (AASI) and endothelin-1 (ET-1) in salt-sensitive and non-salt-sensitive individuals. AASI and symmetric AASI (s-AASI) were used as indicators of arterial stiffness. Plasma ET-1 levels were used as an index of endothelial function. Chronic salt-loading and potassium supplementation were studied in 155 normotensive to mild hypertensive patients from rural northern China. After 3 days of baseline investigation, participants were maintained sequentially for 7 days each on diets of low salt (51...
July 2013: Journal of Clinical Hypertension
Giuseppe Schillaci, Paolo Maggi, Giordano Madeddu, Giacomo Pucci, Elena Mazzotta, Giovanni Penco, Giancarlo Orofino, Barbara Menzaghi, Stefano Rusconi, Laura Carenzi, Benedetto M Celesia, Canio Martinelli, Paolo Bonfanti, Giuseppe Vittorio De Socio
OBJECTIVE: HIV infection has been associated with increased cardiovascular risk. Twenty-four-hour ambulatory blood pressure (BP) is a more accurate and prognostically relevant measure of an individual's BP load than office BP, and the ambulatory BP-derived ambulatory arterial stiffness index (AASI) and symmetric AASI (s-AASI) are established cardiovascular risk factors. METHODS: In the setting of the HIV and HYpertension (HIV-HY) study, an Italian nationwide survey on high BP in HIV infection, 100 HIV-infected patients with high-normal BP or untreated hypertension (72% men, age 48 ± 10 years, BP 142/91 ± 12/7 mmHg) and 325 HIV-negative individuals with comparable age, sex distribution, and office BP (68% men, age 48 ± 10 years, BP 141/90 ± 11/8 mmHg) underwent 24-h ambulatory BP monitoring...
March 2013: Journal of Hypertension
C Catena, S Bernardi, N Sabato, A Grillo, M Ermani, L A Sechi, B Fabris, R Carretta, F Fallo
BACKGROUND AND AIM: Non-alcoholic fatty liver disease (NAFLD) has been found to be strongly related to an increased arterial stiffness in patients with essential hypertension, suggesting a pathophysiologic link between major cardiovascular and metabolic abnormalities associated with liver steatosis and the functional and structural alterations of the arterial wall. The aim of our study was to investigate, in a group of essential hypertensive patients without additional cardiovascular risk factors, the relationship between NAFLD and arterial stiffness...
April 2013: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
Yoshio Matsui, Michael F O'Rourke, Joji Ishikawa, Kazuyuki Shimada, Kazuomi Kario
BACKGROUND: We aimed to investigate the association of the change in the ambulatory arterial stiffness index (AASI) with that in carotid-femoral pulse wave velocity (cfPWV) during treatment with antihypertensive medication. METHODS: We enrolled 207 hypertensive patients treated with olmesartan monotherapy for 12 weeks. Patients were randomly assigned to treatment with hydrochlorothiazide (HCTZ; n = 104) or azelnidipine (n = 103) for 24 weeks. The cfPWV and 24-h ambulatory blood pressure monitoring (ABPM) results were assessed at baseline and 24 weeks later...
August 2012: American Journal of Hypertension
Francesca Dassie, Andrea Grillo, Renzo Carretta, Bruno Fabris, Loredana Macaluso, Moreno Bardelli, Chiara Martini, Agostino Paoletta, Roberto Vettor, Nicola Sicolo, Francesco Fallo, Pietro Maffei
OBJECTIVE: Acromegaly is associated with increased cardiovascular morbidity and mortality and with specific heart and vascular abnormalities. The aim of our study was to investigate arterial stiffness using the ambulatory arterial stiffness index (AASI) and symmetric AASI (Sym-AASI), two indexes derived from 24-h ambulatory blood pressure monitoring (ABPM), in a group of normotensive and hypertensive patients with active acromegaly, compared with normotensive controls (NOR-CTR) or hypertensive controls (HYP-CTR)...
February 2012: European Journal of Endocrinology
Huimin Chen, Qi Hua, Haixia Hou
OBJECTIVE: Increased hemoglobin (Hb) levels are known to be associated with increased cardiovascular events and mortality in hypertensive patients, but the underlying mechanism remains unclear. However, an increased Ambulatory Arterial Stiffness Index (AASI), the surrogate maker of arterial stiffness, has been proven to be an independent predictor of cardiovascular disease. This pilot study evaluated the association between Hb and AASI in untreated essential hypertensive patients without anemia...
2011: Internal Medicine
Nicolas Roberto Robles, Candido Mena, Josefa Martin de Prado, Francisco Garcia Gallego, Antonio Cidoncha, Julio Herrera
OBJECTIVE: Increased central arterial stiffening is the consequence of many disease states such as diabetes, atherosclerosis, and chronic renal disease. Symmetrical Ambulatory Arterial Stiffness Index (Sym-AASI) may provide a simple clinical approach to evaluate arterial stiffness. This study has tried to evaluate the relationship of Sym-AASI with cystatin C levels. DESIGN AND METHODS: The sample subjects were 53 males and 34 females (mean age = 59.3 ± 13.5 years)...
2011: Renal Failure
Andrea Berni, Elisa Ciani, Ilaria Cecioni, Loredana Poggesi, Rosanna Abbate, Maria Boddi
BACKGROUND: A major contributor to poor blood pressure (BP) control is nonadherence to therapy, which remains poorly recognized by physicians. The prevention of hypertension-induced changes in arterial wall, namely increased arterial stiffness and peripheral vascular resistance, is a reasoned adequate end-point of hypertension treatment. Indirect measurement of these arterial factors can be derived from the analysis of 24-hour Ambulatory BP Monitoring (24 h-ABPM). This pilot study evaluated the association between antihypertensive therapy adherence and 24 h-ABPM-derived parameters in hypertensive patients...
February 2011: European Journal of Internal Medicine
Elizabeth S Muxfeldt, Claudia R L Cardoso, Vinicius B Dias, Ana C M Nascimento, Gil F Salles
OBJECTIVE: The ambulatory arterial stiffness index (AASI), derived from ambulatory blood pressure (BP) monitoring recordings, is an indirect marker of arterial stiffness and a potential predictor of cardiovascular risk. Resistant hypertension is defined as uncontrolled office BP despite the use of at least three antihypertensive drugs. The aim of this prospective study was to investigate the AASI prognostic value in patients with resistant hypertension. METHODS: At baseline, 547 patients underwent clinical-laboratory, and 24-h ambulatory BP monitoring examinations...
July 2010: Journal of Hypertension
N R Robles, C Mena, R Macias, E Garcia de Vinuesa, J Herrera, J F Macias
OBJECTIVE: The aim of this study was to investigate the arterial stiffness parameters derived from the proposed linear relationship between SBP and DBP obtained by ABPM, regarding its relationships with two markers of renal disease, microalbuminuria and renal function. DESIGN AND METHODS: One hundred and sixty six patients were studied: 73 males and 93 females mean age 55.2+/-15.5 years. 36.2% were receiving antihypertensive drug treatment. Microalbuminuria was measured in 24-h urine collection as well as albumin to creatinine ratio (ACR) in first morning urine...
April 2010: European Journal of Internal Medicine
George S Stergiou, Anastasios Kollias, Vayia C Rarra, Leonidas G Roussias
BACKGROUND: Ambulatory arterial stiffness index (AASI) has been proposed as a marker of arterial stiffness, which predicts cardiovascular mortality. This study compared the reproducibility of 24-h, daytime, night time, and symmetrical AASI. METHODS: A total of 126 untreated hypertensives (mean age 48.2 +/- 10.7 (s.d.) years, 70 men) underwent 24-h ambulatory blood pressure (ABP) monitoring twice 2-4 weeks apart. The reproducibility of AASI was assessed using the following criteria: (i) repeatability coefficient (RC = 2 x s...
February 2010: American Journal of Hypertension
Benjamin Gavish, Iddo Z Ben-Dov, Jeremy D Kark, Judith Mekler, Michael Bursztyn
We explored the predictive ability of the blood pressure variability ratio (BPVR), defined as the ratio of 24-h ambulatory systolic blood pressure variability to diastolic variability, and evaluated its predictable relation with blood pressure and the Ambulatory Arterial Stiffness Index (AASI). A total of 3433 consecutive patients were followed up to 16 years for all-cause mortality. Blood pressure variability was expressed by the standard deviation. BPVR, which is the systolic-on-diastolic slope estimated by a known type of symmetric regression ('reduced major axis'), was compared with other expressions of this slope and with AASI using other regression procedures...
June 2009: Hypertension Research: Official Journal of the Japanese Society of Hypertension
I Z Ben-Dov, B Gavish, J D Kark, J Mekler, M Bursztyn
Dependence of the ambulatory arterial stiffness index (AASI) on data scattering interferes with its potential clinical relevance. We assessed the correlates and all-cause mortality associations of a modified AASI (s-AASI). AASI was derived from the 24-h diastolic vs. systolic blood pressure linear regression line, whereas s-AASI was derived by symmetric regression (bisecting the line of diastolic vs systolic and systolic vs. diastolic). Of 2918 patients 55% were women; age was 56 +/- 16 years and body mass index was 27...
November 2008: Journal of Human Hypertension
Benjamin Gavish, Iddo Z Ben-Dov, Michael Bursztyn
OBJECTIVES: Systolic blood pressure (SBP) and diastolic blood pressure (DBP) frequently display a linear relationship characterized by the systolic-versus-diastolic slope ('Slope') or the 'ambulatory arterial stiffness index' [AASI = 1 - (diastolic-versus-systolic Slope)] and the correlation coefficient r. We evaluated the effect of using symmetric regression on the AASI and its dependence on clinical characteristics using 24-h ambulatory monitoring. METHODS: Ambulatory monitoring data of 140 patients (age 56 +/- 17 years, 45% men) were retrieved from a service database...
February 2008: Journal of Hypertension
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