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https://www.readbyqxmd.com/read/30120397/hypertension-induced-cognitive-impairment-insights-from-prolonged-angiotensin-ii-infusion-in-mice
#1
Sébastien Foulquier, Pawel Namsolleck, Britt T Van Hagen, Irina Milanova, Mark J Post, W Matthijs Blankesteijn, Bart P Rutten, Jos Prickaerts, Robert J Van Oostenbrugge, Thomas Unger
The causal relation between hypertension and cerebral small vessel disease (cSVD) remains elusive, and appropriate animal models are scarce. We aimed to assess the relevance of prolonged angiotensin II-induced hypertension in mice for the study of cSVD.Adult male C57BL/6 mice were continuously infused for 3 months with Angiotensin II (Ang II; 2 µg/kg/min, sc) or saline (control) via osmotic minipumps. Blood pressure, neurological function, locomotor activity, and working memory (Y-maze alternation task) were assessed throughout the study...
August 17, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/30117489/eus-guided-portal-pressure-measurement-with-videos
#2
REVIEW
Jason B Samarasena, Allen R Yu, Kenneth J Chang
A growing number of studies have explored EUS-guided vascular catheterization due to the relative proximity of the gastrointestinal tract to the major blood vessels of the mediastinum and abdomen. In particular, EUS-guided access of the portal vein (PV) may be favorable given the relative difficulty of PV access through standard percutaneous routes. Two major diagnostic applications of EUS-guided vascular access include angiography and assessment of intravascular pressure. This review will outline the different devices and techniques employed to obtain angiographic visualization and/or direct pressure measurements of the portal circulation...
July 2018: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/30117487/eus-anatomy-of-the-liver-segments
#3
REVIEW
Takeshi Tsujino, Jason B Samarasena, Kenneth J Chang
Clinical applications of EUS for the liver have been recently increasing. They include the screening and diagnosis of liver parenchymal disease and malignant tumors as well as EUS-guided interventions such as hepaticogastrostomy, tumor ablation therapy, and portal pressure gradient measurement. Although the segmental localization of the targeted tumor, bile duct, and vessel in the liver is important to complete these procedures, little information is available regarding hepatic segmental anatomy on EUS. The liver can be visualized with EUS by transgastric and transduodenal scanning, and the EUS determination of segmental location can be achieved using various anatomical landmarks...
July 2018: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/30117146/off-hour-admission-and-impact-on-neurological-outcome-in-endovascular-treatment-for-acute-ischemic-stroke
#4
Pia Löwhagen Hendén, Alexandros Rentzos, Jan-Erik Karlsson, Lars Rosengren, Jonatan Oras, Sven-Erik Ricksten
BACKGROUND AND PURPOSE: In the new era of endovascular treatment for acute ischemic stroke, one of the main predictors of good neurological outcome is a short time interval from stroke onset to recanalization of the occluded vessel. In this study, we examined the effect of on-hour vs off-hour admittance on the time intervals from stroke onset to recanalization in patients with acute ischemic stroke (AIS) undergoing endovascular treatment (EVT). METHODS: One-hundred-ninety-eight patients receiving EVT for anterior AIS between 2007 and 2016 were included...
August 16, 2018: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/30114500/endovascular-repair-of-iliac-vein-laceration-associated-to-complex-pelvic-fracture
#5
Vicente Mosquera, Carlota Fernández, Amer Zanabili, Jose A Del Castro, Mónica G Pandavenes, Manuel Alonso
BACKGROUND: Iliac vein injury associated with pelvic fracture due to blunt trauma is an uncommon and difficult diagnosis but a life-threatening condition which often requires an emergent management. Although open repair has been traditionally used as the treatment of choice in unstable patients, it is controversial, given the difficulty injured vessel exposure in patients with significant retroperitoneal hematoma as well as tamponade effect loss associated to laparotomy. We present a challenging case of iliac vein laceration successfully treated by placement of a self-expanding covered stent...
August 13, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/30114216/arterial-compliance-probe-for-cuffless-evaluation-of-carotid-pulse-pressure
#6
Jayaraj Joseph, Nabeel P M, Malay Ilesh Shah, Mohanasankar Sivaprakasam
OBJECTIVE: Assessment of local arterial properties has become increasingly important in cardiovascular research as well as in clinical domains. Vascular wall stiffness indices are related to local pulse pressure (ΔP) level, mechanical and geometrical characteristics of the arterial vessel. Non-invasive evaluation of local ΔP from the central arteries (aorta and carotid) is not straightforward in a non-specialist clinical setting. In this work, we present a method and system for real-time and beat-by-beat evaluation of local ΔP from superficial arteries-a non-invasive, cuffless and calibration-free technique...
2018: PloS One
https://www.readbyqxmd.com/read/30112753/effects-of-cutaneous-negative-pressure-application-on-perforator-artery-flow-in-healthy-volunteers-a-preliminary-study
#7
Marco Innocenti, Mariella Santini, Emanuela Dreassi, Robin Martin, Dario Melita, Barbara Colombini, Alessandro Innocenti
INTRODUCTION:  The creation of skin flaps based on small perforator vessels is an increasingly popular procedure nowadays; the optimization of their blood supply enhances surgical success. This study evaluates the effects on the flowmetries of 7 days' negative pressure application on the skin surface overlying the muscle fascia emergence of periumbilical perforators of the deep inferior epigastric artery (DIEA). METHODS:  Ten volunteer participants were enrolled...
August 15, 2018: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/30112025/evaluation-of-blood-vessel-injury-oxidative-stress-and-circulating-inflammatory-factors-in-an-l-name-induced-preeclampsia-like-rat-model
#8
Wen Shu, Hanying Li, Hao Gong, Mei Zhang, Xiulong Niu, Yongqiang Ma, Xin Zhang, Wei Cai, Guohong Yang, Maoti Wei, Ning Yang, Yuming Li
Preeclampsia is a pregnancy-specific disease characterized by hypertension as well as proteinuria after the 20th week of pregnancy. Animal models are effective tools for studying the pathogenesis, diagnostic criteria and treatment methods of preeclampsia. The present study sought to establish and evaluate a preeclampsia-like Sprague Dawley (SD) rat model using N-nitro-L-arginine methyl ester (L-NAME). Rats were randomly assigned to 7 groups (n=10 in each): Control rats and rats treated with low-dose L-NAME (40 mg/kg body weight/day) starting from gestational day (GD) 9, medium-L-NAME (75 mg/kg body weight/day) starting from GD 9 (9D ML group), high-dose L-NAME (125 mg/kg body weight/day) starting from GD 9, low-dose L-NAME starting from GD 10, medium-dose L-NAME starting from GD 10 and high-dose L-NAME starting from GD 10...
August 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30111887/wound-healing-in-streptozotocin-induced-diabetic-rats-using-atmospheric-pressure-argon-plasma-jet
#9
Kuang-Yao Cheng, Zhi-Hua Lin, Yu-Pin Cheng, Hsien-Yi Chiu, Nai-Lun Yeh, Tung-Kung Wu, Jong-Shinn Wu
In this study, we used an argon-based round atmospheric-pressure plasma jet (APPJ) for enhancing wound healing in streptozotocin (STZ) induced diabetic rats. The APPJ was characterized by optical emission spectroscopy. We induced Type 1 and Type 2 diabetes in rats with different amounts of STZ combined with normal and high-fat diets, respectively. The wound area ratio of all the plasma-treated normal and diabetic groups was greatly reduced (up to 30%) compared with that of the untreated groups during healing...
August 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30107905/heart-rate-as-a-predictor-of-outcome-following-percutaneous-coronary-intervention
#10
Jessica O'Brien, Christopher M Reid, Nick Andrianopoulos, Andrew E Ajani, David J Clark, Henry Krum, Philippa Loane, Melanie Freeman, Martin Sebastian, Angela L Brennan, James Shaw, Anthony M Dart, Stephen J Duffy
Data from previous studies of patients with heart failure and coronary artery disease suggest that those with higher resting heart rates (HRs) have worse cardiovascular outcomes. We sought to evaluate whether HR immediately before percutaneous coronary intervention (PCI) is an independent predictor for 30-day outcome. We analyzed the outcome of 3,720 patients who had HR recorded before PCI from the Melbourne Interventional Group registry. HR and outcomes were analyzed by quintiles, and secondarily by dichotomizing into <70 or ≥70 beats/min...
July 4, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/30105752/speckle-tracking-carotid-artery-circumferential-strain-is-a-marker-of-arterial-sclerosis-but-not-coronary-atherosis
#11
Daniel M Patton, Terry Li, Marie-France Hétu, Andrew G Day, Erika Preece, Murray F Matangi, Amer M Johri
PURPOSE: Circumferential speckle tracking carotid artery strain is a novel method of quantifying vessel wall stiffness. We hypothesized that carotid wall stiffness would be associated with carotid intimal medial thickening (a medial process associated with risk factors), but not coronary artery disease (an intimal process). METHODS: Bilateral carotid artery ultrasound was conducted on outpatients who had previously undergone elective coronary angiography. Mean carotid artery far wall circumferential strain (FWCS) was assessed for correlations with coronary angiographic stenosis, cardiac risk factors, carotid intima-media thickness (CIMT), and carotid plaque...
August 13, 2018: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/30103491/comparison-of-different-electricity-based-thermal-pretreatment-methods-for-enhanced-bioenergy-production-from-municipal-sludge
#12
E Hosseini Koupaie, T Johnson, C Eskicioglu
This paper presents results for a comprehensive study that compares the performance of three electricity-based thermal pretreatment methods for improving the effectiveness of anaerobic digestion (AD) to process municipal wastewater sludge. The study compares thermal pretreatment using conventional heating (CH), microwave (MW), and radio frequency (RF) heating techniques. The effectiveness of the pretreatment methods was assessed in terms of chemical oxygen demand (COD) and biopolymers solubilization, AD bioenergy production, input electrical energy, and overall net energy production of the sequential pretreatment/AD process...
August 11, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/30102353/ergot-alkaloids-induce-vasoconstriction-of-bovine-uterine-and-ovarian-blood-vessels
#13
D H Poole, S E Lyons, R K Poole, M H Poore
Fescue toxicosis is a syndrome that impairs growth and reproduction in cattle grazing endophyte-infected tall fescue [Lolium arundinaceum [(Schreb.].) Darbysh)] in the U.S., resulting in approximately $1 billion in annual economic loss in species that utilize this forage resource. Approximately 90% of tall fescue contains an endophytic fungus (Epichloë coenophiala) that produces ergot alkaloids. Ergot alkaloids cause vasoconstriction and reduced blood flow to the extremities, however it remains unknown how blood flow to the reproductive organs is affected in cattle...
August 9, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/30102264/isolation-of-atrial-cardiomyocytes-from-a-rat-model-of-metabolic-syndrome-related-heart-failure-with-preserved-ejection-fraction
#14
David Bode, Tim Guthof, Burkert M Pieske, Frank R Heinzel, Felix Hohendanner
In this article, we describe an optimized, Langendorff-based procedure for the isolation of single-cell atrial cardiomyocytes (ACMs) from a rat model of metabolic syndrome (MetS)-related heart failure with preserved ejection fraction (HFpEF). The prevalence of MetS-related HFpEF is rising, and atrial cardiomyopathies associated with atrial remodeling and atrial fibrillation are clinically highly relevant as atrial remodeling is an independent predictor of mortality. Studies with isolated single-cell cardiomyocytes are frequently used to corroborate and complement in vivo findings...
July 26, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/30101218/immunohistochemistry-of-the-circadian-clock-in-mouse-and-human-vascular-tissues
#15
Ciprian B Anea, Ana M Merloiu, David J R Fulton, Vijay Patel, R Dan Rudic
Aim: The circadian clock is a molecular network that controls the body physiological rhythms. In blood vessels, the circadian clock components modulate vascular remodeling, blood pressure, and signaling. The goal in this study was to determine the pattern of expression of circadian clock proteins in the endothelium, smooth muscle, and adventitia of the vasculature of human and mouse tissues. Methods: Immunohistochemistry was performed in frozen sections of mouse aorta, common carotid artery, femoral artery, lung, and heart at 12 AM and 12 PM for Bmal1, Clock, Npas2, Per and other clock components...
2018: Vessel plus
https://www.readbyqxmd.com/read/30101034/counterbalance-modulation-of-vegf-vegfr-activities-by-tnfsf15
#16
Gui-Li Yang, Lu-Yuan Li
Vascular hyperpermeability occurs in angiogenesis and several pathobiological conditions, producing elevated interstitial fluid pressure and lymphangiogenesis. How these closely related events are modulated is a fundamentally important question regarding the maintenance of vascular homeostasis and treatment of disease conditions such as cancer, stroke, and myocardial infarction. Signals mediated by vascular endothelial growth factor receptors, noticeably VEGFR-1, -2, and -3, are centrally involved in the promotion of both blood vessel and lymphatic vessel growth...
2018: Signal Transduction and Targeted Therapy
https://www.readbyqxmd.com/read/30098342/important-roles-of-the-ca-2-sensing-receptor-in-vascular-health-and-disease
#17
REVIEW
Yanjun Guo, Xin Yang, Jialin He, Jingjing Liu, Shiming Yang, Hui Dong
Ca2+ -sensing receptor (CaSR), a member of G protein-coupled receptor family, is widely expressed in the vascular system, including perivascular neurons, vascular endothelial cells (VECs) and vascular smooth muscle cells (VSMCs). When stimulated, CaSR can further increase the cytosolic Ca2+ concentration ([Ca2+ ]cyt ) in two ways: intracellular Ca2+ release from endo/sarcoplasmic reticulum (ER/SR) and extracellular Ca2+ entry through Ca2+ -permeable cation channels. In endothelium, increased Ca2+ subsequently activate nitric oxide synthase (NOS) and intermediate conductance Ca2+ -activated K+ channels (IKCa), resulting in vasodilation through NOS-mediated NO release or membrane hyperpolarization...
August 8, 2018: Life Sciences
https://www.readbyqxmd.com/read/30098187/ultrastructural-morphology-of-the-optic-nerve-head-in-aged-and-glaucomatous-mice
#18
Ying Zhu, Anthony C Pappas, Rui Wang, Philip Seifert, Daniel Sun, Tatjana C Jakobs
Purpose: To study age- and intraocular pressure-induced changes in the glial lamina of the murine optic nerve on the ultrastructural level. Methods: Naïve C57bl/6 mice at various ages spanning the time between early adulthood (3 months) and senescence (30 months) were used in this study. In addition, the intraocular pressure (IOP) was increased in a group of young mice by injection of microbeads into the anterior chamber. The unmyelinated segments of the optic nerve containing the glial lamina were prepared for transmission electron microscopy and imaged at high resolution...
August 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/30098019/efficacy-of-treprostinil-in-the-su5416-hypoxia-model-of-severe-pulmonary-arterial-hypertension-hemodynamic-benefits-are-not-associated-with-improvements-in-arterial-remodelling
#19
Ketul R Chaudhary, Yupu Deng, Colin M Suen, Mohamad Taha, Thomas H Petersen, Shirley H J Mei, Duncan J Stewart
BACKGROUND AND PURPOSE: Pulmonary arterial hypertension (PAH) is a life-threatening disease that leads to progressive pulmonary hypertension, right heart failure and death. Parenteral prostaglandins, including treprostinil, a prostacyclin analogue, represent the most effective medical treatment for severe PAH. We investigated the effect of treprostinil on established severe PAH and underlying mechanisms using the rat SU5416 (SU, a vascular endothelial growth factor receptor-2 inhibitor)-chronic hypoxia (Hx) model of PAH...
August 11, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/30097706/effects-of-thoracic-epidural-anaesthesia-on-the-serosal-microcirculation-of-the-human-small-intestine
#20
A L M Tavy, A F J de Bruin, K van der Sloot, E C Boerma, C Ince, P G Noordzij, D Boerma, M van Iterson
BACKGROUND: The effect of thoracic epidural analgesia (TEA) on splanchnic blood flow during abdominal surgery remains unclear. The purpose of this study was to examine whether the hemodynamic effects of TEA resulted in microcirculatory alterations to the intestinal serosa, which was visualized using incident dark-field (IDF) videomicroscopy. METHODS: An observational cohort study was performed. In 18 patients, the microcirculation of the intestinal serosa was visualized with IDF...
August 10, 2018: World Journal of Surgery
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