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https://www.readbyqxmd.com/read/30317817/-preliminary-comments-on-the-revised-standard-for-diagnosis-of-chronic-obstructive-pulmonary-disease-caused-by-occupational-irritant-chemicals
#1
Y J Yang, L Zhao, Q H Zhu
No abstract text is available yet for this article.
August 20, 2018: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/30317806/-effect-of-long-term-deep-slow-wave-sleep-deprivation-on-the-reproductive-system-in-male-rats
#2
F Xu, N Yang, S Y Liu, Y F Wei, J Y Zhen, Y Y Tian, Y Zhou, Q Yang, Y H Liang, T P Yue, L X Lin
Objective: To investigate the effect of long-term deep slow-wave sleep deprivation on the gonad axis, sperm abnormality rate, and structure of the testis in male rats and possible mechanisms. Methods: A total of 30 specific pathogen-free male Wistar rats aged 5 weeks were randomly divided into slow-wave sleep deprivation group 1 (SD1 group) , slow-wave sleep and sleep time deprivation group 2 (SD2 group) , and control group, with 10 rats in each group. The flower pot method was used to establish a model of sleep deprivation...
August 20, 2018: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/30317799/-research-progress-of-receptor-targeted-hepatic-stellate-cell-in-treatment-of-liver-fibrosis
#3
D Yang
Liver fibrosis is a major public health problem with high morbidity and mortality rate. Despite noteworthy progress in understanding the mechanisms of liver fibrosis, anti-hepatic fibrosis treatments have partial efficacy. The main reason is failure of transported target drug into the target cells, resulting in insufficient concentration of target drugs, and the side effects caused by non-target cells are large. Activation and proliferation of hepatic stellate cell is a key link in the progression of liver fibrosis...
August 20, 2018: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/30317780/-a-case-report-of-hepatitis-b-virus-reactivation-in-both-anti-hbs-hbc-positive-patients-with-chronic-lymphocytic-leukemia-after-chemotherapy
#4
Z R Yang, Q J Sheng, X Zhong, B B Kong, Y Ding, X G Dou
No abstract text is available yet for this article.
July 20, 2018: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/30317779/-clinical-analysis-of-1-058-cases-hepatic-cirrhosis-of-tibetan-nationality
#5
Y Ren, Y H Yang, J Wang
No abstract text is available yet for this article.
July 20, 2018: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/30317774/-long-non-coding-rna-hulc-affects-downstream-related-targets-to-regulate-migration-and-invasion-of-hepatoma-cells
#6
C Zhou, H Wu, Y Liu, C Yin, B Yang
Objective: To investigate the effects of long non-coding RNA HULC on downstream related targets regulating the migration and invasion of hepatoma cells and theirs mechanism of action. Methods: The expression of highly upregulated in liver cancer (HULC) in hepatocellular carcinoma, and adjacent normal liver tissues and different hepatocellular carcinoma cells were detected by qPCR. The correlation between clinicopathological data of HULC and liver cancer patients were analyzed. Dual-luciferase reporter gene detected the interaction between HULC and miR-186...
July 20, 2018: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/30317765/-2-cases-of-fitz-hugh-curtis-syndrome
#7
T J Guo, Y Yang, D F Chen, Y Guo
No abstract text is available yet for this article.
June 20, 2018: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/30317758/-study-on-effect-and-mechanism-of-honokiol-enhancing-tumor-necrosis-factor-related-apoptosis-inducing-ligand-against-hepatocellular-carcinoma-hepg2-cells-via-activating-jnk-signaling-pathway
#8
G Xiao, R Yang, L Dang, C L Dong
Objective: To investigate the effect and intrinsic mechanism of Honokiol (HNK) enhanced tumor necrosis factor-related apoptosis inducing ligand (TRAIL) on hepatocellular carcinoma HepG2 cells. Methods: HepG2 cells were routinely cultured. Firstly, a concentration gradient of HNK was given to observe its effect on the vitality of tumor cells. Western blot were used to detect change in the expression levels of c-jun N-terminal kinase (JNK), death receptor 4 (DR4), and DR5.Secondly, we observed the effect of combined drugs (HNK and TRAIL) on the vitality of tumor cells...
June 20, 2018: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/30317751/-diagnosis-and-differential-diagnosis-of-immunoglobulin-g4-related-hepatobiliary-disease
#9
L Yang, C Q Yang
Immunoglobulin G4-related disease (IgG4-RD) is an immune-mediated disease that share common pathologic, serologic and clinical features. IgG4- RD may include inflammatory pseudotumor, IgG4-related autoimmune hepatitis, and type 1 autoimmune pancreatitis mainly involving liver and clinically classified into three types. IgG4-related sclerosing cholangitis is a rare disease. It is frequently present in association with type 1 autoimmune pancreatitis, so it needs to be distinguishing from primary sclerosing cholangitis...
June 20, 2018: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/30317750/-histopathological-features-and-pathological-diagnosis-of-igg4-related-hepatobiliary-diseases
#10
Y F Yang
IgG4-related diseases (IgG4-RD) can affect multiple organs, including liver and bile ducts, and manifested as IgG4-related sclerosing cholangitis, IgG4-related liver disease, and IgG4-related autoimmune hepatitis. IgG4-RD has common pathogenesis and histopathological features. A histopathological examination is very important for the diagnosis of IgG4-RD. This article reviews the histopathological features and pathological diagnosis of IgG4-RD and IgG4- related hepatobiliary diseases.
June 20, 2018: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/30317728/-mammary-myofibroblastoma-a-clinicopathologic-analysis-of-nine-cases
#11
B H Yu, Q M Bai, X L Xu, W T Yang, J Wang
Objective: To study the clinicopathologic characteristics and differential diagnosis of mammary myofibroblastoma. Methods: Nine cases of mammary myofibroblastoma diagnosed between 2006 and 2017 were collected from the Department of Pathology, Fudan University Shanghai Cancer Center. Clinical and histopathologic features of these nine cases were examined, immunohistochemical staining was performed, FISH analysis for the detection of FOXO1 gene was performed in one case, and follow-up data were also collected...
October 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/30317726/-clinicopathologic-features-of-breast-lymphoma-in-core-needle-biopsy
#12
J Rao, M Ruan, B H Yu, X Q Li, W T Yang, R H Shui
Objective: To investigate the clinicopathologic features and differential diagnosis of breast lymphoma in core needle biopsy. Methods: Seventy-two cases of breast lymphoma in core needle biopsy between 2011 and 2016 were extracted from the pathology database of Fudan University Shanghai Cancer Center. The clinicopathologic features were analyzed. The histological diagnosis of the tumors was based on the WHO classifications of tumors of hematopoietic and lymphoid tissues. Immunohistochemistry and molecular methods were performed to detect related antigens and genes...
October 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/30317675/the-relationship-between-homeobox-b7-expression-and-the-clinical-characteristics-of-patient-with-prostate-cancer
#13
Zhangxing Song, Zhaolin Liao, Yingdong Cui, Chao Yang
BACKGROUND: The prognosis of patients with prostate cancer (PCa) remains poor. METHODS: GSE16560, GSE32448, GSE79957, GSE17951, and TCGA-PRAD were reanalyzed to evaluate the expression of homeobox B7 (HOXB7) between PCa tissues and normal prostate tissues and to characterize the correlation between the expression of HOXB7 and the clinicopathological features of patients with PCa. Gene set enrichment analysis was conducted to investigate the mechanisms. RESULTS: HOXB7 was upregulated in PCa tissues (P = 0...
October 14, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30317665/long-noncoding-rna-c21orf121-bone-morphogenetic-protein-2-microrna-140-5p-gene-network-promotes-directed-differentiation-of-stem-cells-from-human-exfoliated-deciduous-teeth-to-neuronal-cells
#14
Jun Liu, Zeng-Yu Zhang, Hong Yu, Ai-Ping Yang, Ping-Fang Hu, Zhuo Liu, Min Wang
Previous studies have revealed that long noncoding RNA (lncRNA) and microRNA play a crucial role in autism, which is a childhood neurodevelopmental disorder with complicated genetic origins. Hence, the study concerns whether lncRNA C21orf121/bone morphogenetic proteins 2 (BMP2)/miR-140-5p gene network affects directed differentiation of stem cells from human exfoliated deciduous teeth (SHED) to neuronal cells in rats with autism. Autism models were successfully established. The neuron cells that differentiated from SHED cell were identified...
October 14, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30317661/ccn2-promotes-drug-resistance-in-osteosarcoma-by-enhancing-abcg2-expression
#15
Hsiao-Chi Tsai, An-Chen Chang, Chun-Hao Tsai, Yuan-Li Huang, Lijun Gan, Chi-Kuan Chen, Shih-Chia Liu, Te-Yang Huang, Yi-Chin Fong, Chih-Hsin Tang
In recent years, osteosarcoma survival rates have failed to improve significantly with conventional treatment modalities because of the development of chemotherapeutic resistance. The human breast cancer resistance protein/ATP binding cassette subfamily G member 2 (BCRP/ABCG2), a member of the ATP-binding cassette family, uses ATP hydrolysis to expel xenobiotics and chemotherapeutics from cells. CCN family member 2 (CCN2) is a secreted protein that modulates the biological function of cancer cells, enhanced ABCG2 protein expression and activation in this study via the α6β1 integrin receptor and increased osteosarcoma cell viability...
October 14, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30317648/a-dual-role-of-cholesterol-in-osteogenic-differentiation-of-bone-marrow-stromal-cells
#16
Kun Li, Chunmei Xiu, Qiang Zhou, Li Ni, Jun Du, Tingting Gong, Meng Li, Saijilafu, Huilin Yang, Jianquan Chen
Osteoblasts, the chief bone-forming cells, are differentiated from mesenchymal stromal/stem cells. Disruption of this differentiation process can cause osteoporosis, a bone disease characterized by low bone mass and deteriorated bone structure. Cholesterol has been implicated in pathogenesis of osteoporosis, and was recently identified as an endogenous activator of Hedgehog (Hh) signaling. However, its pathological and physiological roles in osteoblast differentiation are still poorly understood. Moreover, it is unclear whether these potential roles played by cholesterol are related to its capability to modulate Hh pathway...
October 14, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30317643/small-molecule-based-generation-of-functional-cardiomyocytes-from-human-umbilical-cord-derived-induced-pluripotent-stem-cells
#17
Kai Hong Wu, Su Yun Wang, Qian Ru Xiao, Yu Yang, Ning Ping Huang, Xu Ming Mo, Jian Sun
The purpose of this study was to investigate the cardiac-differentiation potential of induced pluripotent stem cells (iPSCs) generated from human umbilical cord-derived mesenchymal cells. Spontaneous beating colonies were observed at day 7 after the sequential addition of CHIR99021 and IWP-4. The combined use of CHIR99021 and IWP-4 downregulated the expression of pluripotency markers while upregulating cardiac transcription factors and cardiomyocyte-specific markers. The derived cardiomyocytes demonstrated typical sarcomeric structures and action-potential features; most importantly, the derived cells exhibited responsiveness to β-adrenergic and muscarinic stimulations...
October 14, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30317626/hypermethylation-of-itgbl1-is-associated-with-poor-prognosis-in-acute-myeloid-leukemia
#18
Xin-Yue Lian, Ji-Chun Ma, Jing-Dong Zhou, Ting-Juan Zhang, De-Hong Wu, Zhao-Qun Deng, Zhi-Hui Zhang, Xi-Xi Li, Pin-Fang He, Yang Yan, Jiang Lin, Jun Qian
The current study was aimed to investigate integrin beta-like 1 (ITGBL1) methylation pattern and its clinical relevance in patients with acute myeloid leukemia (AML). Real-time methylation-specific polymerase chain reaction (PCR; RQ-MSP) and bisulfite sequencing PCR (BSP) were performed to detect the methylation of ITGBL1 promoter. Real-time quantitative PCR (RT-qPCR) was performed to analyze ITGBL1 transcript level. The results showed that ITGBL1 methylation level in 131 patients with AML was significantly higher than 29 controls (p < 0...
October 14, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30317616/analysis-of-gene-expression-and-methylation-datasets-identified-adamts9-fkbp5-and-pfkbf3-as-biomarkers-for-osteoarthritis
#19
ZhaoFang Li, RongQiang Zhang, XiaoLi Yang, DanDan Zhang, BaoRong Li, Di Zhang, Qiang Li, YongMin Xiong
BACKGROUND: Osteoarthritis (OA) is a kind of chronic osteoarthropathy and degenerative joint disease. Epigenetic regulation in the gene expression dynamics has become increasingly important in OA. We performed a combined analysis of two types of microarray datasets (gene expression and DNA methylation) to identify methylation-based key biomarkers to provide a better understanding of molecular biological mechanisms of OA. METHODS: We obtained two expression profiling datasets (GSE55235, GSE55457) and one DNA methylation profiling data set (GSE63695) from the Gene Expression Omnibus...
October 14, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30317609/zebrafish-znfl1s-regulate-left-right-asymmetry-patterning-through-controlling-the-expression-of-fgfr1a
#20
Jingyun Li, Feng Gao, Yingmin Zhao, Luqingqing He, Yun Huang, Xiaojing Yang, Yahui Zhou, Lingling Yu, Qingshun Zhao, Xiaohua Dong
Proper left-right (LR) axis establishment is critical for organogenesis in vertebrates. Previously, we reported that zinc finger transcription factors zinc finger transcription factor 1 (znfl1s) are expressed in the tailbud and axial mesoderm in zebrafish. However, a role of znfl1s in LR axis development has not been demonstrated. Here, we discovered that the knockdown of znfl1s using morpholino (MO) in whole embryos or dorsal forerunner cells (DFCs) interrupted LR asymmetry and normal development of the heart, liver, and pancreas...
October 14, 2018: Journal of Cellular Physiology
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