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Yi-Xin Wang, Chong Liu, Ying Shen, Qi Wang, An Pan, Pan Yang, Ying-Jun Chen, Yan-Ling Deng, Qing Lu, Li-Ming Cheng, Xiao-Ping Miao, Shun-Qing Xu, Wen-Qing Lu, Qiang Zeng
BACKGROUND: Bisphenol F (BPF) and bisphenol S (BPS) are increasingly used as alternatives to endocrine disrupting chemical bisphenol A (BPA). Evidence from in vitro and animal studies demonstrates that BPA, BPF and BPS induce oxidative stress, a proposed mechanism that is relevant to various adverse health effects. Evaluation in humans is hampered by the potentially high within-subject variability of urinary measurements. OBJECTIVE: To evaluate the variability and associations of levels of BPA, BPS, BPF and 3 oxidative stress markers [i...
December 12, 2018: Environment International
Guangming Li, Guiyun Hou, Dong Yang, Hu Jian, Weijun Wang
Associations between anxiety, depression and adolescent Internet addiction have been well documented in the literature; however, few published studies have examined these relationships considering the developmental trajectory courses of adolescent Internet addiction as well as the individual differences over time. Using a sample of 1545 Chinese adolescents and 3 waves of data over six months, we examined the longitudinal associations between anxiety and depression and Internet addiction, considering sex and obesity...
December 7, 2018: Addictive Behaviors
Chao Wang, Jiqiu Hou, Hongsen Du, Shasha Yan, Jingjing Yang, Yun Wang, Xiujing Zhang, Lili Zhu, Haibin Zhao
Bone marrow mesenchymal stem cells (BM-MSCs) are recruited to injured site for cardiac self-repairing in acute myocardial infarction (AMI), but the spontaneous mobilization of BM-MSCs is insufficient for self-repairing. Inflammation initiated by necrosis cardiomyocytes induced cardiac remodeling and depression. Given the anti-inflammatory effects of BM-MSCs and the inextricably relationship among inflammation, ventricular remodeling and depression following AMI, methods focused on enhancing BM-MSCs mobilization are promising...
December 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Hai-Fang Chen, Chen Zhang, Yun Yao, Jun-Mao Li, Wen-di Du, Mu-Lan Li, Bei Wu, Shi-Lin Yang, Yu-Lin Feng, Wu-Gang Zhang
TongFengTangSan (TFTS), a traditional Tibetan medicine comprising of Tinospora sinensis (TS), Terminalia chebula Retz (TC) and Trogopterori faeces (TF), is used to treat joint diseases like gout, gout arthritis, swelling, pain etc. Despite the significant therapeutic effects of TFTS, its pharmacological components have not been analyzed so far. Therefore, the chemical composition of the effective part of TFTS was analyzed by ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS/MS)...
November 17, 2018: Journal of Pharmaceutical and Biomedical Analysis
Seunguk Kim, Youngjin Lee, Jae Yeon Kim, Jae Hoon Yang, Hyuk-Jun Kwon, Jae Youn Hwang, Cheil Moon, Jae Eun Jang
A color-sensitive and spectrometer-free sensing method using plasmonic nanohole arrays and the color components, L* , a* , and b* , of the CIELAB defined by the international commission on illumination (CIE) is introduced for the analysis of optically transparent materials in the visible range. Spectral analysis based on plasmonic nanoparticles or nanostructures can be applied to real-time bio-detection, but complex optical instrumentations and low spatial resolution have limited the sensing ability. Therefore, we take an advantage of color image processing instead of spectral analysis which induces the distinctive color information of plasmonic nanohole arrays with different transparent materials...
December 7, 2018: Biosensors & Bioelectronics
Dongqing Wu, Fan Jing, Xin Xi, Lie Ma, Deng Lu, Peng Yang, Ruili Liu
An acid-pasting approach is developed in this work to fabricate the composite of perylenetetracarboxylic diimide (PTCDI) and carbon black in concentrated sulfuric acid. Different from traditional mechanical mixing, the solution-based fabrication strategy enables the sufficient blending of PTCDI as active component and carbon black as conductive agent in the PTCDI/CB composite. Serving as the cathode material, the PTCDI/CB composite shows excellent electrochemical performances in both lithium ion battery (137 mAh g-1 at 100 mA g-1 and 110 mAh g-1 at 2000 mA g-1 ) and sodium ion battery (134 mAh g-1 at 100 mA g-1 and 99 mAh g-1 at 1000 mA g-1 ), which are comparable to the state-of-art organic/inorganic cathode materials...
November 23, 2018: Journal of Colloid and Interface Science
Jiahong Wang, Xuntong Chen, Chonlong Chio, Chun Yang, Erzheng Su, Yongcan Jin, Fuliang Cao, Wensheng Qin
Based on a general understanding that hemicellulose removal is more efficient than delignification for biomass deconstruction, an Aspergillus niger strain producing high xylanase activity was screened out from seventeen strains by clear halo experiments. Low-cost enzyme cocktail with high xylanase activity was produced from wheat straw medium fermented by the Gyx086 strain. The enzyme cocktail with high xylanase activity could more effectively hydrolyze wheat straw than other biomasses. However, only 30% of total carbohydrates could be hydrolyzed to reducing sugar in untreated wheat straw...
December 10, 2018: Bioresource Technology
Xiaoding Huang, Jianwei Zhao, Qiuxiang Xu, Xiaoming Li, Dongbo Wang, Qi Yang, Yang Liu, Ziletao Tao
In this study, an economical and eco-friendly strategy (i.e., adding tofu residue (TR) into waste activated sludge (WAS)) to enhance volatile fatty acid (VFA) production was reported. Experimental results indicated that the maximal VFA yield at T/W ratio (TR/WAS, the ratio of the volatile suspended solids (VSS)) of 0.64 on 5 d was 240.8 mg COD/g VSS, which was 10.2 and 1.1-fold of that in sole WAS and sole TR, respectively. The feasible fermentation time was shortened by 2 days, as compared with sole WAS or sole TR...
December 7, 2018: Bioresource Technology
Junlong Han, Shuhong Yi, Xinlu Zhao, Yundan Zheng, Donghong Yang, Gaofei Du, Xiao-Yan Yang, Qing-Yu He, Xuesong Sun
Stable isotope labeling with amino acids in cell culture (SILAC) is a robust proteomics method with advantages such as reproducibility and easy handling. This method is popular for the analysis of mammalian cells. However, amino acid conversion in bacteria decreases the labeling efficiency and quantification accuracy, limiting the application of SILAC in bacterial proteomics to auxotrophic bacteria or to single labeling with lysine. In this study, we found that adding high concentrations of isotope-labeled (heavy) and natural (light) amino acids into SILAC minimal medium can efficiently inhibit the complicated amino acid conversions...
December 12, 2018: Journal of Proteomics
Xuechao Jiang, Hui Wang, Yongchun Song, Xiaoguang Wang, Fengtong Li, Yang Dong, Jingsheng Wang, Huaming Chen, Zhiyong Yuan
OBJECTIVES: The purpose of this research was to study the outcome of brain metastases in a cohort of patients undergoing a second course of stereotactic image-guided robotic radiosurgery, and to identify predictors corelated with survival. METHODS: A total of 63 patients with primary malignancies underwent a second course of Cyberknife radiosurgery for intracranial progression, including recurrence and new metastases after initial stereotactic radiosurgery (SRS)...
December 12, 2018: World Neurosurgery
Lingyan Sun, Tingting Qu, Danying Wang, Yan Chen, Ying Fu, Qing Yang, Yunsong Yu
Here we report the prevalence of the suppressed vanM gene cluster as a reservoir of vancomycin resistance genes. Among 1284 clinical isolates of enterococci from four hospitals in Hangzhou, China, 55 isolates of Enterococcus faecium and one isolate of Enterococcus faecalis screened positive for the vanM genotype. Antimicrobial susceptibility testing showed that 55 of the 56 vanM-positive isolates were susceptible to vancomycin and teicoplanin. Most of them (54/56) belonged to the main epidemic lineage CC17, mostly the ST78 type...
December 12, 2018: Infection, Genetics and Evolution
Yongquan Li, Jukka Rantanen, Mingshi Yang, Adam Bohr
Amorphous systems prepared with different strategies, such as solid dispersion with colloidal particles or soluble polymers and inclusion complex, have been used for improving solubility and dissolution of poorly water soluble drugs. The purpose of this study was to obtain a deeper understanding of the impact of three different amorphous systems prepared by spray drying with silica, polyvinylpyrrolidone (PVP) or 2-hydroxypropyl-β-cyclodextrin (HPβCD) using indomethacin (IND) as a model drug. IND was spray dried with silica, PVP or HPβCD at different mass ratios, and the obtained powders were characterized with respect to colloidal silica particle redispersion, morphology, thermal properties, solid state properties and physical stability...
December 12, 2018: European Journal of Pharmaceutical Sciences
Chongye Fang, Xianbin Cai, Shuhei Hayashi, Shumei Hao, Haruhiko Sakiyama, Xuanjun Wang, Qin Yang, Shizuo Akira, Shuhei Nishiguchi, Noriko Fujiwara, Hiroko Tsutsui, Jun Sheng
Caffeine intake is associated with a reduced risk developing non-alcoholic fatty liver disease (NAFLD), but the underlying molecular mechanisms remain to be fully elucidated. We report here that caffeine markedly improved high fat diet-induced NAFLD in mice resulting in a 10-fold increase in circulating IL-6 levels, leading to STAT3 activation in the liver. Interestingly, the expression of IL-6 mRNA was not increased in the liver, but increased substantially in the muscles of caffeine-treated mice. Caffeine was found to stimulate IL-6 production in cultured myotubes but not in hepatocytes, adipocytes, or macrophages...
December 12, 2018: Biochimica et biophysica acta. Molecular and cell biology of lipids
Xiu-Fei Cao, Yong-Jun Dai, Ming-Yang Liu, Xiang-Yang Yuan, Cong-Cong Wang, Yang-Yang Huang, Wen-Bin Liu, Guang-Zhen Jiang
This study was conducted to understand the effect of high-fat diet challenge on lipid transport and endoplasmic reticulum stress in blunt snout bream. Ninety fish (average weight: 41.84 ± 0.07 g) were randomly fed a control diet (6% fat) or a high-fat diet (11% fat) for 9 weeks. The growth performance and feed utilization efficiency were evaluated at the end of the trial. The liver samples of both groups were harvested for molecular analysis and histological evaluation. Compared to the Control group, the high-fat diet group showed no effects on either growth performance or energy intake in blunt snout bream...
December 12, 2018: Biochimica et biophysica acta. Molecular and cell biology of lipids
Hyuk Jin Yun, Ai Wern Chung, Lana Vasung, Edward Yang, Tomo Tarui, Caitlin K Rollins, Cynthia M Ortinau, P Ellen Grant, Kiho Im
Accurate parcellation and labeling of primary cortical sulci in the human fetal brain is useful for regional analysis of brain development. However, human fetal brains show large spatio-temporal changes in brain size, cortical folding patterns, and relative position/size of cortical regions, making accurate automatic sulcal labeling challenging. Here, we introduce a novel sulcal labeling method for the fetal brain using spatio-temporal gyrification information from multiple fetal templates. First, spatial probability maps of primary sulci are generated on the templates from 23 to 33 gestational weeks and registered to an individual brain...
December 12, 2018: NeuroImage
Hualu Han, Runhua Zhang, Gaifen Liu, Huiyu Qiao, Zhensen Chen, Yang Liu, Xiaoyi Chen, Dongye Li, Yongjun Wang, Xihai Zhao
Reduction in cerebral blood flow (CBF), one of the major metrics for cerebral perfusion, is associated with many brain disorders. Therefore, early characterization of CBF prior to occurrence of symptoms is essential for prevention of cerebral ischemic disorders. We hypothesized that large artery atherosclerosis might be a potential indicator for decline in cerebral perfusion. The aim of this study was to investigate the relationship between large artery atherosclerosis and CBF in asymptomatic adults. A total of 134 asymptomatic subjects (mean age, 56...
December 12, 2018: NeuroImage
Ying Wang, Shukui Zhou, Ranxing Yang, Qingsong Zou, Kaile Zhang, Qinghua Tian, Weixin Zhao, Lijuan Zong, Qiang Fu
Cell-seeded scaffolds are a common route of cell transplantation for bladder repair and reconstruction. However, when cell suspensions are harvested, proteolytic enzymes often cause extracellular matrix damage and loss of intercellular junctions. To overcome this problem, we developed a bioengineered three-dimensional bladder patch comprising porous scaffolds and multilayered adipose-derived stem cell (ASC) sheets, and evaluated its feasibility for bladder regeneration in a rat model. Adipose-derived stem cells (ASCs) were labeled with ultrasmall super-paramagnetic iron oxide (USPIO) nanoparticles...
December 12, 2018: Acta Biomaterialia
Yuhua Li, Yang Sun, Tianle Tang, Yinbo Niu, Xiaoqiang Li, Ming Xie, Hongchuan Jin, Qibing Mei
ETHNOPHARMACOLOGICAL RELEVANCE: The development of a multidrug-resistant (MDR) phenotype is a main obstacle to the successful treatment of breast cancer. Saponins of several herbs are considered as promising candidates for drug resistance treatment. We extracted Paris saponin VII (PS VII) from Trillium tschonoskii Maxim. and investigated whether it could sensitize chemoresistant breast cancer cells MCF-7/ADR to the cytotoxic effects of adriamycin. MATERIALS AND METHODS: MCF-7/ADR cells were exposed to 0...
December 12, 2018: Journal of Ethnopharmacology
Yang Chen, Yumeng Lin, Xiwei Tian, Qianhui Li, Ju Chu
The yeast Starmerella bombicola is known to produce sophorolipids (SLs) by fermentation method. In the fermentative production of SLs, at least three phases i.e. hydrophilic phase of glucose, ions and acidic-form SLs; hydrophobic phase of oil and lactone-form SLs; solid phase of cell biomass and SLs crystals are present in the broth. Therefore, a rapid and real-time detection of residual oil and SLs can provide valuable information in the regulation and optimization of the process to better produce SLs effectively...
December 12, 2018: Journal of Microbiological Methods
Lihua Yang, Hanghui Kong, Jen-Pan Huang, Ming Kang
To consistently and objectively delineate species-level divergence from population subdivision has been a challenge in systematics. This is particularly evident in naturally fragmented and allopatric systems in which small population size often leads to extreme population structuring. Here we evaluated the robustness of the species delimitation methods implemented in BEAST, BPP, and iBPP in the Primulina hochiensis complex comprising four described and one candidate species (five taxa in total) distributed in karst landscapes of southern China...
December 12, 2018: Molecular Phylogenetics and Evolution
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