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https://www.readbyqxmd.com/read/27699133/classification-of-basal-cell-carcinoma-in-human-skin-using-machine-learning-and-quantitative-features-captured-by-polarization-sensitive-optical-coherence-tomography
#1
Tahereh Marvdashti, Lian Duan, Sumaira Z Aasi, Jean Y Tang, Audrey K Ellerbee Bowden
We report the first fully automated detection of basal cell carcinoma (BCC), the most commonly occurring type of skin cancer, in human skin using polarization-sensitive optical coherence tomography (PS-OCT). Our proposed automated procedure entails building a machine-learning based classifier by extracting image features from the two complementary image contrasts offered by PS-OCT, intensity and phase retardation (PR), and selecting a subset of features that yields a classifier with the highest accuracy. Our classifier achieved 95...
September 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27667271/-association-between-ambulatory-arterial-stiffness-index-with-left-ventricular-mass-index-in-the-elderly-hypertensive-patients
#2
H H Chen, Y S Sun, M L Liu
Objective: To investigate the relationship between ambulatory arterial stiffness index (AASI) and left ventricular mass index (LVMI) in the elderly hypertensive patients. Methods: This study population consisted of 332 elderly hypertensive patients, who hospitalized in our department from January 2012 to December 2014.AASI was calculated from 24 h ambulatory BP monitoring recordings and LVMI from echocardiography examination.According to the median value of AASI, patients were divided to less than the AASI median group (low AASI group) and equal to or above the AASI median group (high AASI group)...
September 24, 2016: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/27405964/arterial-stiffness-going-a-step-beyond
#3
Benjamin Gavish, Joseph L Izzo
Interest in arterial stiffness has been fueled by the scientific and clinical implications of its "vicious cycle" relationship with aging and systolic blood pressure. In physical terms, stiffness is the slope of the relationship between an artery's distending pressure and its cross-sectional area or volume. Pulse wave velocity (PWV, in m/s), the most common arterial stiffness indicator, is usually measured by the foot-to-foot time and distance method and is proportional to [stiffness × area (or volume)](1/2) at a given pressure...
July 12, 2016: American Journal of Hypertension
https://www.readbyqxmd.com/read/27317518/update-to-an-open-label-clinical-trial-of-vismodegib-as-neoadjuvant-before-surgery-for-high-risk-basal-cell-carcinoma-bcc
#4
Gina P Kwon, Mina Sarah Ally, Irene Bailey-Healy, Anthony E Oro, Jinah Kim, Anne Lynn Chang, Sumaira Aasi, Jean Y Tang
No abstract text is available yet for this article.
July 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27262708/management-of-high-risk-squamous-cell-carcinoma-of-the-skin
#5
REVIEW
Teresa Fu, Sumaira Z Aasi, S Tyler Hollmig
Non-melanoma skin cancer (NMSC) is the most common malignancy in the USA, with cutaneous squamous cell carcinomas (cSCCs) constituting approximately 20 % of all NMSC. While cSCCs typically behave in an indolent fashion and can be cured with local destructive or surgical methods, a small subset metastasizes and induces significant morbidity and mortality. Identifying and aggressively treating these "high-risk" cSCCs (HRcSCCs) is thus paramount. Recent improvements in staging cSCCs appear to offer better risk stratification than earlier staging criteria...
July 2016: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/27250350/peripheral-artery-disease-and-blood-pressure-profile-abnormalities-in-hemodialysis-patients
#6
Francesca Viazzi, Giovanna Leoncini, Elena Ratto, Giulia Storace, Annalisa Gonnella, Debora Garneri, Barbara Bonino, Francesca Cappadona, Emanuele L Parodi, Daniela Verzola, Giacomo Garibotto, Roberto Pontremoli
BACKGROUND: Patients undergoing chronic hemodialysis (HD) are at increased risk for peripheral artery disease (PAD). Both ankle-brachial index (ABI) and ambulatory blood pressure monitoring (ABPM) in the interdialytic period have been shown to be strong predictors of all-cause mortality. METHODS: This cross-sectional study investigated the relationship between ABPM profile and ABI in 81 HD patients. ABPM was measured throughout a 44-h midweek interdialytic period...
June 1, 2016: Journal of Nephrology
https://www.readbyqxmd.com/read/27160235/basal-cell-skin-cancer-version-1-2016-nccn-clinical-practice-guidelines-in-oncology
#7
Christopher K Bichakjian, Thomas Olencki, Sumaira Z Aasi, Murad Alam, James S Andersen, Daniel Berg, Glen M Bowen, Richard T Cheney, Gregory A Daniels, L Frank Glass, Roy C Grekin, Kenneth Grossman, Susan A Higgins, Alan L Ho, Karl D Lewis, Daniel D Lydiatt, Kishwer S Nehal, Paul Nghiem, Elise A Olsen, Chrysalyne D Schmults, Aleksandar Sekulic, Ashok R Shaha, Wade L Thorstad, Malika Tuli, Marshall M Urist, Timothy S Wang, Sandra L Wong, John A Zic, Karin G Hoffmann, Anita Engh
Basal cell carcinoma (BCC) of the skin is the most common cancer, with a higher incidence than all other malignancies combined. Although it is rare to metastasize, patients with multiple or frequently recurring BCC can suffer substantial comorbidity and be difficult to manage. Assessment of risk is a key element of management needed to inform treatment selection. The overall management of BCC primarily consists of surgical approaches, with radiation therapy as an alternate or adjuvant option. Many superficial therapies for BCC have been explored and continue to be developed, including topicals, cryosurgery, and photodynamic therapy...
May 2016: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/27118486/symmetric-ambulatory-arterial-stiffness-index-in-the-young
#8
Minh B Nguyen, Pamela Singer, Fredrick Kaskel, Joseph Mahgerefteh
The ambulatory arterial stiffness index (AASI) and the symmetric ambulatory arterial stiffness index (s-AASI) have been shown to correlate to arterial stiffness in adults. This study assesses these indices with anthropometric and blood pressure (BP) measures in children. A total of 102 children at a pediatric hypertension clinic who had ambulatory blood pressure monitoring (ABPM) done from 2009 to 2013 were included (75% males, 7-22yo, 47% hypertensive, 24% prehypertensive, and 34% white-coat hypertensives)...
June 2016: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/27050070/arterial-stiffness-bmi-dipping-status-and-ace-d-i-polymorphism-in-type-1-diabetic-children
#9
I Pietrzak, W Fendler, I Dróżdż, B Mianowska, W Młynarski, A Szadkowska
THE AIM: of the study was to investigate clinical and genetic determinants of arterial stiffness in children and adolescents with type 1 diabetes mellitus. MATERIAL AND METHODS: 122 patients (mean age: 16.0±2.35 years), with an average diabetes duration of 5.0 years and without evidence of arterial hypertension were recruited. Ambulatory arterial stiffness index (AASI) was assessed with 24-h automatic blood pressure monitoring. Body weight, height, HbA1c and plasma lipids were measured...
May 2016: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/27045747/skin-cancer-prevention-and-treatment-in-solid-organ-transplant-patients-a-survey-of-the-international-transplant-skin-cancer-collaborative
#10
Ange Wang, An-Wen Chan, Sumaira Aasi, Carolyn Lee, Michael Krathen
No abstract text is available yet for this article.
May 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/27025241/low-dose-hydrocortisone-replacement-is-associated-with-improved-arterial-stiffness-index-and-blood-pressure-dynamics-in-severely-adrenocorticotrophin-deficient-hypopituitary-male-patients
#11
Lucy-Ann Behan, David Carmody, Bairbre Rogers, Mark J Hannon, Colin Davenport, William Tormey, Diarmuid Smith, Christopher J Thompson, Alice Stanton, Amar Agha
OBJECTIVE: Increased cardiovascular and cerebrovascular morbidity and mortality in hypopituitary subjects may be linked to inappropriate glucocorticoid exposure; however, the pathophysiology remains unclear. We aimed to examine the effect of three commonly prescribed hydrocortisone (HC) regimens on vascular risk factors. DESIGN: An open crossover study randomising ten hypopituitary men with severe adrenocorticotrophic hormone deficiency to three HC dose regimens: dose A (20mg mane and 10mg tarde), dose B (10mg mane and 10mg tarde) and dose C (10mg mane and 5mg tarde)...
June 2016: European Journal of Endocrinology
https://www.readbyqxmd.com/read/26914830/alopecia-areata-and-health-related-quality-of-life-a-systematic-review-and-meta-analysis
#12
F Rencz, L Gulácsi, M Péntek, N Wikonkál, P Baji, V Brodszky
BACKGROUND: No systematic review has yet evaluated the available evidence on health-related quality of life (HRQOL) in alopecia areata (AA). OBJECTIVES: To conduct a systematic review and meta-analysis of HRQOL studies among patients diagnosed with AA. METHODS: A systematic search was performed for papers published between 1946 and 15 December 2014 in Medline, Embase, Web of Science, CINAHL, PsycINFO and the Cochrane Library. Random-effects meta-analyses were conducted to pool data...
September 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/26812298/the-association-between-metabolic-complications-and-arterial-hypertension-in-obese-adolescents
#13
Malgorzata Wojcik, Jadwiga Malek, Dominika Janus, Kamil Fijorek
OBJECTIVE: There is increasing evidence for the contribution of obesity and its metabolic sequels in the development of arterial hypertension (AH). METHODS: The casual blood pressure (CBP), 24hABPM, ambulatory arterial stiffness index (AASI) and symmetric (sAASI) ambulatory arterial stiffness index (both derived from a 24 h ABPM) and selected laboratory tests were performed in 130 obese (mean BMI SDS 4.2) adolescents at the mean age of 13.7 years. RESULTS: AH was diagnosed in 36...
December 2015: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/26684589/is-arterial-stiffness-predicted-by-continuous-metabolic-syndrome-score-in-obese-children
#14
Katarina Prochotska, Laszlo Kovacs, Eva Vitariusova, Janusz Feber
The aim of the article was to evaluate arterial stiffness, an early marker of increased cardiovascular risk, in relation to obesity. The continuous metabolic syndrome (cMetS) score was calculated as sum of Z score of mean arterial pressure, body mass index, serum glucose, triglyceride, and high-density lipoprotein cholesterol in 144 obese patients and 66 nonobese controls. Ambulatory arterial stiffness index (AASI) was calculated as 1 minus regression slope of diastolic on systolic blood pressure from ambulatory blood pressure measurements...
January 2016: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/26631849/ambulatory-arterial-stiffness-in-chronic-kidney-disease-a-methodological-review
#15
REVIEW
Andrea László, György Reusz, János Nemcsik
Cardiovascular mortality is the leading cause of death in chronic kidney disease (CKD) and end-stage renal disease (ESRD). This can be explained in part by an increased and progressive calcification of the medial layer of the large arteries leading to arterial stiffening. The prognostic value of measurements of arterial stiffness, especially pulse wave velocity (PWV), in the general population and in CKD and ESRD patients is high, and is above that of traditional risk factors with respect to cardiovascular outcome...
April 2016: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/26571979/evaluation-of-arterial-stiffness-in-elderly-with-prehypertension
#16
Patil Satish Gurunathrao, Aithala Manjunatha, Das Kusal Kanti
Arterial stiffness is an independent marker of cardiovascular (CV) risk that increases with age. Hypertension is known to augment the age-related arterial stiffness. The influence of prehypertension on arterial stiffness in elderly is least studied. The present study was aimed to assess the age-associated arterial stiffness in the elderly subjects with prehypertension. A cross sectional study was conducted on elderly subjects aged 60-80 years with prehypertension (n=25) and age-matched normotensives (n=20)...
January 2015: Indian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/26523988/sedentary-behaviour-patterns-and-arterial-stiffness-in-a-spanish-adult-population-the-evident-trial
#17
MULTICENTER STUDY
A García-Hermoso, B Notario-Pacheco, J I Recio-Rodríguez, V Martínez-Vizcaíno, E Rodrigo de Pablo, J F Magdalena Belio, M A Gómez-Marcos, L García-Ortiz
OBJECTIVE: Arterial stiffness is a contributor to the development of atherosclerosis and cardiovascular disease. The aim of the study was to analyse the relationship between sedentary behaviour and arterial stiffness in a Spanish adult population. METHODS: This cross-sectional study included 1365 subjects belonging to the EVIDENT project. Physical activity and sedentary behaviour were measured objectively over 7 days using ActiGraph accelerometers. Thresholds of 10 consecutive minutes were used to estimate the daily sedentary time in bouts ≥10 min...
December 2015: Atherosclerosis
https://www.readbyqxmd.com/read/26490088/seeking-a-blood-pressure-independent-measure-of-vascular-properties
#18
Jochen Steppan, Gautam Sikka, Daijiro Hori, Daniel Nyhan, Dan E Berkowitz, Allan Gottschalk, Viachaslau Barodka
Pulse wave velocity (PWV) and pulse pressure (PP) are blood pressure (BP)-dependent surrogates for vascular stiffness. Considering that there are no clinically useful markers for arterial stiffness that are BP-independent, our objective was to identify novel indices of arterial stiffness and compare them with previously described markers. PWV and PP were measured in young and old male Fisher rats and in young and old male spontaneously hypertensive rats (SHR) over a wide range of BPs. The BP dependence of these and several other indices of vascular stiffness were evaluated...
January 2016: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/26461882/the-relationship-between-25-hydroxyvitamin-d-levels-and-ambulatory-arterial-stiffness-index-in-newly-diagnosed-and-never-treated-hypertensive-patients
#19
Özgül Malçok Gürel, Ayşe Bilgiç, Bora Demirçelik, Meltem Özaydin, Fadime Bozduman, Zübeyde Aytürk, Hakki Yilmaz, Asli Atar, Yusuf Selçoki, Beyhan Eryonucu
OBJECTIVES: Vitamin D insufficiency has been shown to be associated with cardiac dysfunctions, such as cardiac hypertrophy and hypertension, in animal studies. Arterial stiffness is a prognostic marker for cardiovascular disease. Previous studies have demonstrated that 25-hydroxyvitamin D [25(OH)D] levels were negatively correlated with arterial stiffness index. The aim of this study was to investigate the relationship between 25(OH)D levels and arterial stiffness, which is evaluated using an ambulatory arterial stiffness index (AASI), in patients who have untreated and newly diagnosed essential hypertension...
February 2016: Blood Pressure Monitoring
https://www.readbyqxmd.com/read/26343814/effects-of-empagliflozin-on-blood-pressure-and-markers-of-arterial-stiffness-and-vascular-resistance-in-patients-with-type-2-diabetes
#20
RANDOMIZED CONTROLLED TRIAL
R Chilton, I Tikkanen, C P Cannon, S Crowe, H J Woerle, U C Broedl, O E Johansen
AIMS: To determine the effects of empagliflozin on blood pressure (BP) and markers of arterial stiffness and vascular resistance in patients with type 2 diabetes mellitus (T2DM). METHODS: We conducted a post hoc analysis of data from a phase III trial in patients with T2DM and hypertension receiving 12 weeks' empagliflozin and four phase III trials in patients with T2DM receiving 24 weeks' empagliflozin (cohort 1, n = 823; cohort 2, n = 2477). BP was measured using 24-h BP monitoring (cohort 1) or seated office measurements (cohort 2)...
December 2015: Diabetes, Obesity & Metabolism
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