Adrien Georges, Min-Lee Yang, Takiy-Eddine Berrandou, Mark K Bakker, Ozan Dikilitas, Soto Romuald Kiando, Lijiang Ma, Benjamin A Satterfield, Sebanti Sengupta, Mengyao Yu, Jean-François Deleuze, Delia Dupré, Kristina L Hunker, Sergiy Kyryachenko, Lu Liu, Ines Sayoud-Sadeg, Laurence Amar, Chad M Brummett, Dawn M Coleman, Valentina d'Escamard, Peter de Leeuw, Natalia Fendrikova-Mahlay, Daniella Kadian-Dodov, Jun Z Li, Aurélien Lorthioir, Marco Pappaccogli, Aleksander Prejbisz, Witold Smigielski, James C Stanley, Matthew Zawistowski, Xiang Zhou, Sebastian Zöllner, Philippe Amouyel, Marc L De Buyzere, Stéphanie Debette, Piotr Dobrowolski, Wojciech Drygas, Heather L Gornik, Jeffrey W Olin, Jerzy Piwonski, Ernst R Rietzschel, Ynte M Ruigrok, Miikka Vikkula, Ewa Warchol Celinska, Andrzej Januszewicz, Iftikhar J Kullo, Michel Azizi, Xavier Jeunemaitre, Alexandre Persu, Jason C Kovacic, Santhi K Ganesh, Nabila Bouatia-Naji
Fibromuscular dysplasia (FMD) is an arteriopathy associated with hypertension, stroke and myocardial infarction, affecting mostly women. We report results from the first genome-wide association meta-analysis of six studies including 1556 FMD cases and 7100 controls. We find an estimate of SNP-based heritability compatible with FMD having a polygenic basis, and report four robustly associated loci (PHACTR1, LRP1, ATP2B1, and LIMA1). Transcriptome-wide association analysis in arteries identifies one additional locus (SLC24A3)...
October 15, 2021: Nature Communications