keyword
https://read.qxmd.com/read/38530749/a-peptide-selectively-recognizes-gram-negative-bacteria-and-forms-a-bacterial-extracellular-trap-bet-through-interfacial-self-assembly
#1
JOURNAL ARTICLE
Xiao-Ling Sha, Gan-Tian Lv, Qing-Hua Chen, Xin Cui, Lei Wang, Xu Cui
An innate immune system intricately leverages unique mechanisms to inhibit colonization of external invasive Bacteria, for example human defensin-6, through responsive encapsulation of bacteria. Infection and accompanying antibiotic resistance stemming from Gram-negative bacteria aggregation represent an emerging public health crisis, which calls for research into novel anti-bacterial therapeutics. Herein, inspired by naturally found host-defense peptides, we design a defensin-like peptide ligand, bacteria extracellular trap (BET) peptide, with modular design composed of targeting, assembly, and hydrophobic motifs with an aggregation-induced emission feature...
March 26, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/38522706/poly-l-lactic-acid-gelatin-electrospun-membrane-loaded-bone-marrow-derived-mesenchymal-stem-cells-attenuate-erectile-dysfunction-caused-by-cavernous-nerve-injury
#2
JOURNAL ARTICLE
Daoyuan Hu, Chang Liu, Yunlong Ge, Lei Ye, Qiang Guo, Yuhang Xi, Wenliang Zhu, Dejuan Wang, Tao Xu, Jianguang Qiu
Radical prostatectomy (RP) can cause neurogenic erectile dysfunction (ED), which negatively affects the quality of life of patients with prostate cancer. Currently, there is a dearth of effective therapeutic strategies. Although stem cell therapy is promising, direct cell transplantation to injured cavernous nerves is constrained by poor cell colonization. In this study, poly-L-lactic acid (PLLA)/gelatin electrospun membranes (PGEM) were fabricated to load bone marrow-derived mesenchymal stem cells (BM-MSCs) as a patch to be placed on injured nerves to alleviate ED...
March 22, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38521809/sex-drives-colonic-mucin-sialylation-in-wild-mice
#3
JOURNAL ARTICLE
Alexander R Bennett, Iris Mair, Andrew Muir, Hannah Smith, Larisa Logunova, Andrew Wolfenden, Jonathan Fenn, Ann E Lowe, Janette E Bradley, Kathryn J Else, David J Thornton
Mucin protein glycosylation is important in determining biological properties of mucus gels, which form protective barriers at mucosal surfaces of the body such as the intestine. Ecological factors including: age, sex, and diet can change mucus barrier properties by modulating mucin glycosylation. However, as our understanding stems from controlled laboratory studies in house mice, the combined influence of ecological factors on mucin glycosylation in real-world contexts remains limited. In this study, we used histological staining with 'Alcian Blue, Periodic Acid, Schiff's' and 'High-Iron diamine' to assess the acidic nature of mucins stored within goblet cells of the intestine, in a wild mouse population (Mus musculus)...
March 23, 2024: Scientific Reports
https://read.qxmd.com/read/38521185/glp-1r-signaling-modulates-colonic-energy-metabolism-goblet-cell-number-and-survival-in-the-absence-of-gut-microbiota
#4
JOURNAL ARTICLE
Thomas U Greiner, Ara Koh, Eduard Peris, Mattias Bergentall, Malin E V Johansson, Gunnar C Hansson, Daniel J Drucker, Fredrik Bäckhed
OBJECTIVE: Theut microbiota increases energy availability through fermentation of dietary fibers to short-chain fatty acids in conventionally raised mice. Energy deficiency in germ-free (GF) mice increases glucagon-like peptide-1 (GLP-1) levels, which slows intestinal transit. To further analyze the role of GLP-1-mediated signaling in this model of energy deficiency, we re-derived mice lacking GLP-1 receptor (GLP-1R KO) as GF. METHODS: GLP-1R KO mice were rederived as GF through hysterectomy and monitored for 30 weeks...
March 21, 2024: Molecular Metabolism
https://read.qxmd.com/read/38520724/fatty-acid-oxidation-supports-lymph-node-metastasis-of-cervical-cancer-via-acetyl-coa-mediated-stemness
#5
JOURNAL ARTICLE
Li Yuan, Hongye Jiang, Yan Jia, Yuandong Liao, Caixia Shao, Yijia Zhou, Jiaying Li, Yan Liao, Hua Huang, Yuwen Pan, Weijia Wen, Xueyuan Zhao, Linna Chen, Xu Jing, Chaoyun Pan, Wei Wang, Shuzhong Yao, Chunyu Zhang
Accumulating evidence indicates that metabolic reprogramming of cancer cells supports the energy and metabolic demands during tumor metastasis. However, the metabolic alterations underlying lymph node metastasis (LNM) of cervical cancer (CCa) have not been well recognized. In the present study, it is found that lymphatic metastatic CCa cells have reduced dependency on glucose and glycolysis but increased fatty acid oxidation (FAO). Inhibition of carnitine palmitoyl transferase 1A (CPT1A) significantly compromises palmitate-induced cell stemness...
March 23, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38518647/scutellarin-a-flavonoid-compound-from-scutellaria-barbata-suppresses-growth-of-breast-cancer-stem-cells-in-vitro-and-in-tumor-bearing-mice
#6
JOURNAL ARTICLE
Hui Ma, Grace Gar-Lee Yue, Julia Kin-Ming Lee, Si Gao, Ka-Ki Yuen, Wen Cheng, Xiang Li, Clara Bik-San Lau
BACKGROUND: Scutellaria barbata D. Don (SB), commonly known as Ban Zhi Lian and firstly documented by Shigong Chen, is a dried whole plant that has been studied for its therapeutic effects on breast cancer, colon cancer, and prostate cancer. Among its various compounds, scutellarin (SCU) has been demonstrated with anti-tumor effects. PURPOSE: This study aimed to evaluate the effects of SB water extract (SBW) and scutellarin on breast cancer stem cells (BCSCs), and to investigate their potential therapeutic effects on breast tumors in mice...
February 9, 2024: Phytomedicine
https://read.qxmd.com/read/38517952/intestinal-tuft-cell-immune-privilege-enables-norovirus-persistence
#7
JOURNAL ARTICLE
Madison S Strine, Eric Fagerberg, Patrick W Darcy, Gabriel M Barrón, Renata B Filler, Mia Madel Alfajaro, Nicole D'Angelo-Gavrish, Fang Wang, Vincent R Graziano, Bridget L Menasché, Martina Damo, Ya-Ting Wang, Michael R Howitt, Sanghyun Lee, Nikhil S Joshi, Daniel Mucida, Craig B Wilen
The persistent murine norovirus strain MNVCR6 is a model for human norovirus and enteric viral persistence. MNVCR6 causes chronic infection by directly infecting intestinal tuft cells, rare chemosensory epithelial cells. Although MNVCR6 induces functional MNV-specific CD8+ T cells, these lymphocytes fail to clear infection. To examine how tuft cells promote immune escape, we interrogated tuft cell interactions with CD8+ T cells by adoptively transferring JEDI (just EGFP death inducing) CD8+ T cells into Gfi1b-GFP tuft cell reporter mice...
March 22, 2024: Science Immunology
https://read.qxmd.com/read/38517383/cinobufotalin-regulates-the-usp36-c-myc-axis-to-suppress-malignant-phenotypes-of-colon-cancer-cells-in-vitro-and-in-vivo
#8
JOURNAL ARTICLE
Yongjun Hu, Ming Luo
Ubiquitin-specific protease 36 (USP36) has been reported to exhibit oncogenic effects in various malignancies, but the function of USP36 in colon cancer progression remains indefinite. Herein, we aimed to determine the role and mechanism of USP36 in malignant phenotypes of colon cancer cells and explore the potential drug targeting USP36. Bioinformatics analyses indicated that USP36 is highly expressed and significantly related to tumor stages in colon cancer. Besides, USP36 was further up-regulated in oxaliplatin (Oxa)-resistant colon cancer cells...
March 15, 2024: Aging
https://read.qxmd.com/read/38509965/identification-and-analysis-of-prognostic-metabolic-characteristics-in-colon-adenocarcinoma
#9
JOURNAL ARTICLE
Yang Yang, Xinyu Yang, Shiqi Ren, Yang Cao, Ziheng Wang, Zhouyang Cheng
Colon adenocarcinoma (COAD) is a highly lethal gastrointestinal malignancy. The five-year survival rate of metastatic colorectal cancer remains low, at 14 percent. Numerous publications have suggested a role for peroxisome proliferator-activated receptors (PPARs) in malignancy. Recent studies have shown that PPARs, as nuclear transcription factors, may serve as potential targets for the treatment of metabolic syndrome tumors and their associated complications. However, the molecular mechanism has not been thoroughly investigated...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38509106/autologous-cell-transplantation-for-treatment-of-colorectal-aganglionosis-in-mice
#10
JOURNAL ARTICLE
Weikang Pan, Ahmed A Rahman, Takahiro Ohkura, Rhian Stavely, Kensuke Ohishi, Christopher Y Han, Abigail Leavitt, Aki Kashiwagi, Alan J Burns, Allan M Goldstein, Ryo Hotta
Neurointestinal diseases cause significant morbidity and effective treatments are lacking. This study aimes to test the feasibility of transplanting autologous enteric neural stem cells (ENSCs) to rescue the enteric nervous system (ENS) in a model of colonic aganglionosis. ENSCs are isolated from a segment of small intestine from Wnt1::Cre;R26iDTR mice in which focal colonic aganglionosis is simultaneously created by diphtheria toxin injection. Autologous ENSCs are isolated, expanded, labeled with lentiviral-GFP, and transplanted into the aganglionic segment in vivo...
March 20, 2024: Nature Communications
https://read.qxmd.com/read/38508971/mesenchymal-stem-cells-attenuates-hirschsprung-disease-associated-enterocolitis-by-reducing-m1-macrophages-infiltration-via-cox-2-dependewhant-mechanism
#11
JOURNAL ARTICLE
Xinyao Meng, Jun Xiao, Jing Wang, Minxian Sun, Xuyong Chen, Luyao Wu, Ke Chen, Zejian Li, ChenZhao Feng, Didi Zhuansun, Jixin Yang, Xiaojuan Wu, Donghai Yu, Wei Li, Yonghua Niu, Ying He, Mingfa Wei, Feng Chen, Bo Xiong, Jiexiong Feng, Tianqi Zhu
OBJECTIVE AND DESIGN: Hirschsprung disease-associated enterocolitis (HAEC) is a common life-threatening complication of Hirschsprung disease (HSCR). We aimed to investigate the effectiveness, long-term safety and the underlying mechanisms of Mesenchymal stem cells (MSCs) based therapy for HAEC. MATERIAL OR SUBJECTS: Specimens from HSCR and HAEC patients were used to assess the inflammatory condition. Ednrb knock-out mice was used as HAEC model. MSCs was intraperitoneally transplanted into HAEC mice...
March 4, 2024: Journal of Pediatric Surgery
https://read.qxmd.com/read/38504374/tmem120b-strengthens-breast-cancer-cell-stemness-and-accelerates-chemotherapy-resistance-via-%C3%AE-1-integrin-fak-taz-mtor-signaling-axis-by-binding-to-myh9
#12
JOURNAL ARTICLE
Ran Hu, Yu Cao, Yuanyuan Wang, Tingting Zhao, Kaibo Yang, Mingwei Fan, Mengyao Guan, Yuekang Hou, Jiao Ying, Xiaowen Ma, Ning Deng, Xun Sun, Yong Zhang, Xiupeng Zhang
BACKGROUND: Breast cancer stem cell (CSC) expansion results in tumor progression and chemoresistance; however, the modulation of CSC pluripotency remains unexplored. Transmembrane protein 120B (TMEM120B) is a newly discovered protein expressed in human tissues, especially in malignant tissues; however, its role in CSC expansion has not been studied. This study aimed to determine the role of TMEM120B in transcriptional coactivator with PDZ-binding motif (TAZ)-mediated CSC expansion and chemotherapy resistance...
March 19, 2024: Breast Cancer Research: BCR
https://read.qxmd.com/read/38503815/bone-marrow-derived-mesenchymal-stem-cells-mitigate-chronic-colitis-and-enteric-neuropathy-via-anti-inflammatory-and-anti-oxidative-mechanisms
#13
JOURNAL ARTICLE
Rhian Stavely, Ainsley M Robinson, Sarah Fraser, Rhiannon T Filippone, Vanesa Stojanovska, Rajaraman Eri, Vasso Apostolopoulos, Samy Sakkal, Kulmira Nurgali
Current treatments for inflammatory bowel disease (IBD) are often inadequate due to limited efficacy and toxicity, leading to surgical resection in refractory cases. IBD's broad and complex pathogenesis involving the immune system, enteric nervous system, microbiome, and oxidative stress requires more effective therapeutic strategies. In this study, we investigated the therapeutic potential of bone marrow-derived mesenchymal stem cell (BM-MSC) treatments in spontaneous chronic colitis using the Winnie mouse model which closely replicates the presentation and inflammatory profile of ulcerative colitis...
March 20, 2024: Scientific Reports
https://read.qxmd.com/read/38496665/human-pluripotent-stem-cell-derived-organoids-reveal-a-role-for-wnt-signaling-in-dorsal-ventral-patterning-of-the-hindgut
#14
Na Qu, Abdelkader Daoud, Daniel O Kechele, Jorge O Múnera
The cloaca is a transient structure that forms in the terminal hindgut giving rise to the rectum dorsally and the urogenital sinus ventrally. Similarly, human hindgut cultures derived from human pluripotent stem cells generate human colonic organoids (HCOs) which also contain co-developing urothelial tissue. In this study, our goal was to identify pathways involved in cloacal patterning and apply this to human hindgut cultures. RNA-seq data comparing dorsal versus ventral cloaca in e10.5 mice revealed that WNT signaling was elevated in the ventral versus dorsal cloaca...
March 6, 2024: bioRxiv
https://read.qxmd.com/read/38493107/a-matter-of-differentiation-equine-enteroids-as-a-model-for-the-in-vivo-intestinal-epithelium
#15
JOURNAL ARTICLE
Christina Windhaber, Anna Heckl, Georg Csukovich, Barbara Pratscher, Iwan Anton Burgener, Nora Biermann, Franziska Dengler
Epithelial damage due to gastrointestinal disorders frequently causes severe disease in horses. To study the underlying pathophysiological processes, we aimed to establish equine jejunum and colon enteroids (eqJE, eqCE) mimicking the in vivo epithelium. Therefore, enteroids were cultivated in four different media for differentiation and subsequently characterized histomorphologically, on mRNA and on protein level in comparison to the native epithelium of the same donor horses to identify ideal culture conditions for an in vitro model system...
March 16, 2024: Veterinary Research
https://read.qxmd.com/read/38491161/notoginsenoside-r1-promotes-lgr5-stem-cell-and-epithelium-renovation-in-colitis-mice-via-activating-wnt-%C3%AE-catenin-signaling
#16
JOURNAL ARTICLE
Zhi-Lun Yu, Rui-Yang Gao, Cheng Lv, Xiao-Long Geng, Yi-Jing Ren, Jing Zhang, Jun-Yu Ren, Hao Wang, Fang-Bin Ai, Zi-Yi Wang, Bei-Bei Zhang, Dong-Hui Liu, Bei Yue, Zheng-Tao Wang, Wei Dou
Inflammatory bowel disease (IBD) is characterized by persistent damage to the intestinal barrier and excessive inflammation, leading to increased intestinal permeability. Current treatments of IBD primarily address inflammation, neglecting epithelial repair. Our previous study has reported the therapeutic potential of notoginsenoside R1 (NGR1), a characteristic saponin from the root of Panax notoginseng, in alleviating acute colitis by reducing mucosal inflammation. In this study we investigated the reparative effects of NGR1 on mucosal barrier damage after the acute injury stage of DSS exposure...
March 15, 2024: Acta Pharmacologica Sinica
https://read.qxmd.com/read/38490099/cancer-stem-cells-the-important-role-of-cd-markers-signaling-pathways-and-micrornas
#17
REVIEW
Amir Gholamzad, Niloofar Khakpour, Elaheh Mohandesi Khosroshahi, Saba Asadi, Zeinab Khazaei Koohpar, Arash Matinahmadi, Ali Jebali, Mohsen Rashidi, Mehrdad Hashemi, Farzaneh Hasani Sadi, Mehrdad Gholamzad
For the first time, a subset of small cancer cells identified in acute myeloid leukemia has been termed Cancer Stem Cells (CSCs). These cells are notorious for their robust proliferation, self-renewal abilities, significant tumor-forming potential, spread, and resistance to treatments. CSCs are a global concern, as it found in numerous types of cancer, posing a real-world challenge today. Our review encompasses research on key CSC markers, signaling pathways, and MicroRNA in three types of cancer: breast, colon, and liver...
February 28, 2024: Pathology, Research and Practice
https://read.qxmd.com/read/38487879/small-extracellular-vesicles-from-infarcted-and-failing-heart-accelerate-tumor-growth
#18
JOURNAL ARTICLE
Tal Caller, Itai Rotem, Olga Shaihov-Teper, Daria Lendengolts, Yeshai Schary, Ruty Shai, Efrat Glick-Saar, Dan Dominissini, Menachem Motiei, Idan Katzir, Rachela Popovtzer, Merav Nahmoud, Alex Boomgarden, Crislyn D'Souza-Schorey, Nili Naftali-Shani, Jonathan Leor
BACKGROUND: Myocardial infarction (MI) and heart failure are associated with an increased incidence of cancer. However, the mechanism is complex and unclear. Here, we aimed to test our hypothesis that cardiac small extracellular vesicles (sEVs), particularly cardiac mesenchymal stromal cell-derived sEVs (cMSC-sEVs), contribute to the link between post-MI left ventricular dysfunction (LVD) and cancer. METHODS: We purified and characterized sEVs from post-MI hearts and cultured cMSCs...
March 15, 2024: Circulation
https://read.qxmd.com/read/38485099/probiotic-consortia-protect-the-intestine-against-radiation-injury-by-improving-intestinal-epithelial-homeostasis
#19
JOURNAL ARTICLE
Li-Wei Xie, Hai-Yan Lu, Lin-Feng Tang, Feng-Ling Tang, Rui-Qiu Zhu, Di-Fan Wang, Shang Cai Md, Ye Tian, Ming Li
PURPOSE: Radiation-induced intestinal injuries (RIII) commonly occur during abdomin-pelvic cancer radiotherapy; however, no effective prophylactic or therapeutic agents are available to manage RIII currently. This study aimed to clarify the potential of probiotic consortium supplementation in alleviating RIII. MATERIALS AND METHODS: Male C57BL/6J mice were orally administered a probiotic mixture comprising Bifidobacterium longum BL21, Lactobacillus paracasei LC86, and Lactobacillus plantarum Lp90 for 30 days before exposure to 13 Gy of whole abdominal irradiation (WAI)...
March 12, 2024: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/38484479/from-the-archives-of-md-anderson-cancer-center-monomorphic-epitheliotropic-intestinal-t-cell-lymphoma-a-case-with-an-unusual-immunophenotype-and-discussion-of-differential-diagnosis
#20
REVIEW
Nicholas J Dcunha, Qing Wei, Beenu Thakral, L Jeffrey Medeiros
Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is a rare and aggressive T-cell neoplasm associated with poor survival. We report a case of MEITL that presented as an ulcerated mass in the jejunum with perforation. Microscopic examination showed that the neoplasm involved the full thickness of the intestinal wall, extended into the mesentery, and was composed of monomorphic, small to medium-size cells. Immunohistochemical analysis showed that the neoplastic cells were positive for T-cell receptor (TCR) delta, CD3, CD7, CD8 (small subset), BCL-2 and TIA-1, and negative for TCR beta, CD4, CD5, CD10, CD20, CD30, CD34, CD56, CD57, CD99, ALK, cyclin D1, granzyme B, MUM1/IRF4, and TdT...
March 8, 2024: Annals of Diagnostic Pathology
keyword
keyword
169326
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.