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https://www.readbyqxmd.com/read/30103094/adenosquamous-carcinoma-of-the-right-colon-a-case-report-and-review-of-the-literature
#1
Omar Toumi, Badii Hamida, Manel Njima, Amal Bouchrika, Houssem Ammar, Amira Daldoul, Sonia Zaied, Sadok Ben Jabra, Rahul Gupta, Faouzi Noomen, Khadija Zouari
INTRODUCTION: Adenosquamous carcinoma is a rare colorectal tumor with both an adenocarcinoma and a squamous cell carcinoma component. To the best of our knowledge, only few cases have been reported in the literature. CASE PRESENTATION: We report a case of a 46-year-old woman, hospitalized for large bowel obstruction syndrome. Computed tomography scan showed an irregular mass of the right colic angle, responsible for an occlusive syndrome with distension of the right colon, the appendix and the terminal ileum...
July 11, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/30101026/management-of-manec-of-the-colon-and-rectum-a-comprehensive-review-of-the-literature
#2
Anna Paspala, Nikolaos Machairas, Anastasia Prodromidou, Eleftherios Spartalis, Argyrios Ioannidis, Ioannis D Kostakis, Dimetrios Papaconstantinou, Nikolaos Nikiteas
Mixed adeno-neuroendocrine carcinoma (MANEC) is a rare pathological diagnosis recently acknowledged by the World Health Organization in 2010. MANEC is a neoplasm characterized by significant histological heterogeneity and is characterized by the simultaneous presence of both adenocarcinomatous and neuroendocrine differentiation; their definition includes each component found in at least 30% of the tumor. Colorectal MANEC constitutes an uncommon type of malignant tumor. The true prevalence of colorectal MANEC has not been precisely defined and published studies are limited to case reports and small case series...
August 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/30099687/design-synthesis-cytotoxicity-and-molecular-modeling-studies-of-some-novel-fluorinated-pyrazole-based-heterocycles-as-anticancer-and-apoptosis-inducing-agents
#3
Eman A Fayed, Sally I Eissa, Ashraf H Bayoumi, Nirvana A Gohar, Ahmed B M Mehany, Yousry A Ammar
3,5-Diamino-4-(3-trifluoromethylphenyldiazenyl)-1H-pyrazole was used as a starting scaffold for the synthesis of new pyrazole-based heterocycles to study their effects on the proliferation of three human cancer cell lines; human liver carcinoma cell line (HepG-2), colon cancer cell line (HCT-116) and human breast cancer cell line (MCF-7) using MTT assay. The synthesized compounds were characterized on the basis of IR, 1 H NMR, 13 C NMR, mass spectral data and elemental analysis results. Cytotoxicity assay results revealed that some of the compounds showed potent growth inhibition against all the cell lines tested, with IC50 values in the range of 0...
August 11, 2018: Molecular Diversity
https://www.readbyqxmd.com/read/30099342/long-noncoding-rna-kcna3-inhibits-the-progression-of-colorectal-carcinoma-through-down-regulating-yap1-expression
#4
Xiaolin Zhong, Muhan Lü, Juyi Wan, Tiejun Zhou, Bo Qin
Long non-coding RNAs (lncRNAs) regulate diverse cellular processes, and their anomalous expression exert an essential role in the progression of many kinds of cancers, including colorectal carcinoma (CRC). The objective of this study was to investigate the role of lncRNA kcna3 and its underlying mechanism in CRC progression. The expression of lncRNA kcna3 in human CRC tissues and the adjacent non-tumor tissues was evaluated by RT-PCR. The correlations between lncRNA kcna3 expression levels and the overall survival (OS), as well as the clinicopathological features of CRC patients were analyzed...
August 9, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30096783/phosphocholine-modified-lipooligosaccharides-of-haemophilus-influenzae-inhibit-atp-induced-il-1%C3%AE-release-by-pulmonary-epithelial-cells
#5
Katrin Richter, Christian Koch, Alexander Perniss, Philipp M Wolf, Elke K H Schweda, Sven Wichmann, Sigrid Wilker, Ilona Magel, Michael Sander, J Michael McIntosh, Winfried Padberg, Veronika Grau
Phosphocholine-modified bacterial cell wall components are virulence factors enabling immune evasion and permanent colonization of the mammalian host, by mechanisms that are poorly understood. Recently, we demonstrated that free phosphocholine (PC) and PC-modified lipooligosaccharides (PC-LOS) from Haemophilus influenzae , an opportunistic pathogen of the upper and lower airways, function as unconventional nicotinic agonists and efficiently inhibit the ATP-induced release of monocytic IL-1β. We hypothesize that H...
August 8, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/30094696/metachronous-rectal-metastasis-from-primary-transverse-colon-cancer-a-case-report
#6
Shigehiro Kojima, Tsuguo Sakamoto, Yuko Nagai, Masayuki Honda, Fumihiro Ogawa
BACKGROUND: Colorectal metastases from primary colorectal cancers are very rare, and little is known about their epidemiological aspects or the best diagnostic and therapeutic strategies. Herein, we report a case of a 65-year-old woman with suspected metachronous metastasis to the rectum from primary transverse colon cancer. CASE PRESENTATION: The patient underwent a laparoscopic extended right hemicolectomy for primary transverse colon cancer. Histopathological examination showed moderately differentiated adenocarcinoma, and the tumor was diagnosed as stage IIA (T3, N0, M0)...
August 9, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/30093473/synchronous-colon-cancer-with-pulmonary-metastasis-and-follicular-variant-of-papillary-thyroid-cancer-metastasising-to-kidney
#7
Arun Kadamkulam Syriac, Murtaza Mirza, Ashley Rose Malekunnel, Alberto Locante, Palak Desai
Thyroid malignancies are one of the fastest growing cancers in the world, with the majority being papillary thyroid cancer. Follicular variant of papillary thyroid cancer accounts for about 10%-20% of papillary thyroid carcinomas. The usual sites for metastases of these tumours are lungs and bones with renal metastases being extremely rare. We describe a case of a 64-year-old woman who presented with abdominal pain. On subsequent imaging, she was found to have a colonic mass with metastatic lesions in the lungs and tumour involving left kidney...
August 9, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/30093110/lncrna-snar-upregulates-grb2-associated-binding-protein-2-and-promotes-proliferation-of-ovarian-carcinoma-cells
#8
Yiping Huang, Yingying Hu, Zujian Jin, Zhaojun Shen
BACKGROUND: The functionality of lncRNA snaR has only been characterized in breast cancer and colon cancer. The aim of the current study is to explore the involvement of lncRNA snaR in ovarian carcinoma (OC). MATERIALS AND METHODS: Expression of lncRNA snaR and GRB2-associated binding protein 2 (GAB2) in plasma of both patients with OC and healthy females was detected by qRT-PCR. Application value of plasma lncRNA snaR in the diagnosis of OC was evaluated by ROC analysis...
August 1, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/30093071/deletion-of-garp-on-mouse-regulatory-t-cells-is-not-sufficient-to-inhibit-the-growth-of-transplanted-tumors
#9
E Vermeersch, S Liénart, A Collignon, S Lucas, A Gallimore, C Gysemans, D Unutmaz, K Vanhoorelbeke, S F De Meyer, W Maes, H Deckmyn
GARP is a transmembrane protein that presents latent TGF-β1 on the surface of regulatory T cells (Tregs). Neutralizing anti-GARP monoclonal antibodies that prevent the release of active TGF-β1, inhibit the immunosuppressive activity of human Tregs in vivo. In this study, we investigated the contribution of GARP on mouse Tregs to immunosuppression in experimental tumors. Unexpectedly, Foxp3 conditional garp knockout (KO) mice challenged orthotopically with GL261 tumor cells or subcutaneously with MC38 colon carcinoma cells did not show prolonged survival or delayed tumor growth...
July 30, 2018: Cellular Immunology
https://www.readbyqxmd.com/read/30090970/vitamin-d-deficiency-has-a-negative-impact-on-cetuximab-mediated-cellular-cytotoxicity-against-human-colon-carcinoma-cells
#10
Lorenzo Mortara, Marzia B Gariboldi, Annalisa Bosi, Marco Bregni, Graziella Pinotti, Luigina Guasti, Alessandro Squizzato, Douglas M Noonan, Elena Monti, Leonardo Campiotti
BACKGROUND: Hypovitaminosis D is associated with an adverse prognosis in colon cancer patients, possibly due to the effects of the vitamin on the immune system. Antibody-dependent cell-mediated cytotoxicity (ADCC) significantly contributes to the anti-tumor effects of monoclonal antibodies, including cetuximab, an epidermal growth factor receptor (EGFR)-targeted monoclonal antibody that is frequently added to chemotherapy in the treatment of colon cancer. OBJECTIVE: The present study evaluates the association between vitamin D serum levels and the ability of ex vivo NK cells to support cetuximab-mediated ADCC in colon cancer cell lines...
August 9, 2018: Targeted Oncology
https://www.readbyqxmd.com/read/30090005/endoscopic-diagnosis-of-sessile-serrated-adenoma-polyp-with-and-without-dysplasia-carcinoma
#11
REVIEW
Takashi Murakami, Naoto Sakamoto, Akihito Nagahara
Sessile serrated adenoma/polyps (SSA/Ps) are early precursor lesions in the serrated neoplasia pathway, which results in colorectal carcinomas with BRAF mutations, methylation for DNA repair genes, a CpG island methylator phenotype, and high levels of microsatellite instability. Some of these lesions can rapidly become dysplastic or invasive carcinomas that exhibit high lymphatic invasion and lymph node metastasis potentials. Detecting serrated lesions, including SSA/Ps with and without dysplasia/carcinoma, is critical, but SSA/Ps can be difficult to detect, are inconsistently identified by endoscopists and pathologists, and are often incompletely resected...
August 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/30088538/icariin-reduces-human-colon-carcinoma-cell-growth-and-metastasis-by-enhancing-p53-activities
#12
Meili Tian, Shuang Yang, Xinpeng Yan
Icariin has been reported to possess high anticancer activity. Colon carcinoma is one of the leading causes of cancer-related mortality worldwide. Here, the anticancer activity of icariin against HCT116 colon carcinoma cells and the possible underlying mechanism were studied. The trypan blue staining assay, wound healing assay, clonogenic assay, CCK-8 assay, and Annexin V-FITC/PI double staining method were carried out to determine the changes of HCT116 cell growth and migration. mRNA and protein expressions were determined by quantitative real-time PCR and western blot, respectively...
August 6, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/30087856/a-novel-dpyd-variant-associated-with-severe-toxicity-of-fluoropyrimidines-role-of-pre-emptive-dpyd-genotype-screening
#13
Chi C Tong, Ching W Lam, Ka O Lam, Victor H F Lee, Mai-Yee Luk
Background: The fluoropyrimidine anticancer drug, especially 5- fluorouracil (5-FU) and its prodrug capecitabine are still being the backbone of chemotherapeutic regimens for colorectal cancer. Dihydropyrimidine dehydrogenase (DPD) is the crucial enzyme in the catabolism of 5-FU. Over the past 30 years, there is substantial clinical evidence showing that DPD deficiency is strongly associated with severe and fatal fluoropyrimidine-induced toxicity. Patients and methods: A 49-year-old lady with resected stage III carcinoma of sigmoid colon was scheduled to have a course of 5-FU based adjuvant chemotherapy...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/30087398/reversine-inhibits-colon-carcinoma-cell-migration-by-targeting-jnk1
#14
Mohamed Jemaà, Yasmin Abassi, Chamseddine Kifagi, Myriam Fezai, Renée Daams, Florian Lang, Ramin Massoumi
Colorectal cancer is one of the most commonly diagnosed cancers and the third most common cause of cancer-related death. Metastasis is the leading reason for the resultant mortality of these patients. Accordingly, development and characterization of novel anti-cancer drugs limiting colorectal tumor cell dissemination and metastasis are needed. In this study, we found that the small molecule Reversine reduces the migration potential of human colon carcinoma cells in vitro. A coupled kinase assay with bio-informatics approach identified the c-Jun N-terminal kinase (JNK) cascade as the main pathway inhibited by Reversine...
August 7, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30086790/pcbp1-depletion-promotes-tumorigenesis-through-attenuation-of-p27-kip1-mrna-stability-and-translation
#15
Hongshun Shi, Hui Li, Ronghua Yuan, Wen Guan, Xiaomei Zhang, Shaoyang Zhang, Wenliang Zhang, Fang Tong, Li Li, Zhihong Song, Changwei Wang, Shulan Yang, Haihe Wang
BACKGROUND: Poly C Binding Protein 1 (PCBP1) is an RNA-binding protein that binds and regulates translational activity of subsets of cellular mRNAs. Depletion of PCBP1 is implicated in various carcinomas, but the underlying mechanism in tumorigenesis remains elusive. METHODS: We performed a transcriptome-wide screen to identify novel bounding mRNA of PCBP1. The bind regions between PCBP1 with target mRNA were investigated by using point mutation and luciferase assay...
August 7, 2018: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/30086059/risk-factors-associated-with-pouch-adenomas-in-patients-with-familial-adenomatous-polyposis
#16
Petra Ganschow, Silke Trauth, Ulf Hinz, Anja Schaible, Markus W Büchler, Martina Kadmon
BACKGROUND: Restorative proctocolectomy with ileal pouch-anal reconstruction is the standard prophylactic surgical procedure for patients with familial adenomatous polyposis. However, several groups have reported the development of adenomas and even carcinomas within the ileal pouch. The predisposing factor was the time interval after pouch surgery in some studies, but it was the severity of the initial colonic disease and duodenal adenomatosis in others. OBJECTIVE: The aim of this study was to further clarify the prevalence of pouch adenomas, clinical risk factors, and a possible phenotype-genotype relation in a large population of patients with familial adenomatous polyposis, as well as to analyze pouch adenoma-free survival...
September 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/30085964/factors-related-to-colorectal-cancer-in-advanced-adenomas-and-serrated-polyps-a-further-step-toward-individualized-surveillance
#17
Adán-Merino Luisa, Aldeguer-Martínez Mercedes, Barrio-Antoranz Jose, Burdaspal-Moratilla Ana, Martín Chávarri Sonia
AIM: The risk of presenting synchronous or metachronous neoplasm, either adenoma or carcinoma, increases after an initial colonic lesion develops. It is known as tumor multicentricity and constitutes the rationale for surveillance programs. This study was designed to identify the clinical, pathologic, and molecular features related to previous or synchronous colorectal cancer (CRC) in patients with advanced adenomas (AA) or serrated polyps (SP). PATIENTS AND METHODS: We carried out a prospective analysis of 4143 colonoscopies performed at our medical department between 1 September 2014 and 30 September 2015...
August 6, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/30085111/malignant-and-nonmalignant-complications-of-the-rectal-stump-in-patients-with-inflammatory-bowel-disease
#18
Joren R Ten Hove, Jonathan M K Bogaerts, Michiel T J Bak, Miangela M Laclé, Vincent Meij, Lauranne A A P Derikx, Frank Hoentjen, Nofel Mahmmod, Sebastiaan A van Tuyl, Bas Oldenburg
Background: Patients with refractory inflammatory bowel disease (IBD) might require a subtotal colectomy with construction of an ileostomy. Due to the risk of nerve damage and pelvic sepsis, the diverted rectum is often left in situ. Evidence on long-term complications of this rectal stump is limited, particularly in patients with Crohn's disease (CD). In addition to the risk of development of neoplasia, diversion proctitis is a frequently reported rectal stump associated complication...
August 1, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/30083271/carcinoma-associated-fibroblasts-promote-the-stemness-and-chemoresistance-of-colorectal-cancer-by-transferring-exosomal-lncrna-h19
#19
Jing Ren, Liang Ding, Dongya Zhang, Guoping Shi, Qianyun Xu, Sunan Shen, Yaping Wang, Tingting Wang, Yayi Hou
Long non-coding RNAs (lncRNAs) are involved in the pathology of various tumors, including colorectal cancer (CRC). The crosstalk between carcinoma- associated fibroblasts (CAFs) and cancer cells in the tumor microenvironment promotes tumor development and confers chemoresistance. In this study, we further investigated the underlying tumor-promoting roles of CAFs and the molecular mediators involved in these processes. Methods: The AOM/DSS-induced colitis-associated cancer (CAC) mouse model was established, and RNA sequencing was performed...
2018: Theranostics
https://www.readbyqxmd.com/read/30082676/synthesis-molecular-docking-and-anticancer-activity-of-diflunisal-derivatives-as-cyclooxygenase-enzyme-inhibitors
#20
Göknil Pelin Coşkun, Teodora Djikic, Taha Bartu Hayal, Nezaket Türkel, Kemal Yelekçi, Fikrettin Şahin, Ş Güniz Küçükgüzel
Cyclooxygenase enzymes play a vital role in inflammatory pathways in the human body. Apart from their relation with inflammation, the additional involvement of COX-2 enzyme with cancer activity was recently discovered. In some cancer types the level of COX-2 enzyme is increased indicating that this enzyme could be a suitable target for cancer therapy. Based on these findings, we have synthesized some new diflunisal thiosemicarbazides and 1,2,4-triazoles and tested them against androgen-independent prostate adenocarcinoma (PC-3), colon carcinoma (HCT-116), human breast cancer (T47D), breast carcinoma (MCF7) and human embryonic kidney (HEK-293) cell lines...
August 6, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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