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https://www.readbyqxmd.com/read/30339194/biomarker-analysis-beyond-angiogenesis-ras-raf-mutation-status-tumour-sidedness-and-second-line-ramucirumab-efficacy-in-patients-with-metastatic-colorectal-carcinoma-from-raise-a-global-phase-3-study
#1
T Yoshino, D C Portnoy, R Obermannová, G Bodoky, J Prausová, R Garcia-Carbonero, T Ciuleanu, P García-Alfonso, A L Cohn, E Van Cutsem, K Yamazaki, S Lonardi, K Muro, T W Kim, K Yamaguchi, A Grothey, J O'Connor, J Taieb, S R Wijayawardana, R R Hozak, F Nasroulah, J Tabernero
Background: Second-line treatment with ramucirumab+FOLFIRI improved overall survival (OS) versus placebo+FOLFIRI for patients with metastatic colorectal carcinoma (mCRC) (hazard ratio [HR]=0.84, 95%CI=0.73-0.98, P=0.022). Post-hoc analyses of RAISE patient data examined the association of RAS/RAF mutation status and the anatomical location of the primary CRC tumour (left versus right) with efficacy parameters. Patients and methods: Patient tumour tissue was classified as BRAF mutant, KRAS/NRAS ("RAS") mutant, or RAS/BRAF wild-type...
October 18, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/30334944/an-unusual-location-of-squamous-cell-carcinoma-and-a-rare-cutaneous-infection-caused-by-serratia-marcescens-on-the-tumoral-tissue-a-case-report
#2
Nurhayat Ozkan Sevencan, Elcin Kal Cakmakliogullari, Aysegul Ertinmaz Ozkan, Burcak Kayhan
RATIONALE: Serratia marcescens (S. marcescens) is an opportunistic pathogen of the Enterobacteriaceae family. Although S. marcescens is known to cause sepsis, meningitis, endocarditis, urinary system and ocular infections, skin infections are sporadic. Squamous cell carcinoma (SCC) is the most aggressive skin cancer type that is often located in the head and neck region, and rarely in the scalp tissue. PATIENT CONCERNS: An 89-years-old male patient was diagnosed with SCC three years ago...
October 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30332953/synthesis-cytotoxicity-antimicrobial-and-docking-simulation-of-novel-pyrazolo-3-4-d-pyrimidine-and-pyrazolo-4-3-e-1-2-4-triazolo-3-4-c-pyrimidine-derivatives
#3
Hamdi M Hassaneen, Fatma M Saleh, Tayseer A Abdallah, Magda F Mohamed, Yasmin Sh Mohamed, Enas M Awad, Ismail A Abdelhamid
Isobutyrohydrazonoyl bromide 1 was used as precursor for the synthesis of 4-imino-3-isopropyl-1-(4-nitrophenyl)-1,4-dihydro-5H-pyrazolo[3,4-d]pyrimidin-5-amine 4, which was converted to hydrazino derivative 5 by heating with hydrazine hydrate at reflux. Hydrazino as well as imino and amino derivatives undergo condensation and cyclization reactions to give pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[3,4-c]pyrimidine derivatives, respectively. Antimicrobial studies are performed using two-gram positive bacteria and two-gram negative bacteria...
October 17, 2018: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/30324717/helicobacter-pylori-vaca-a-distinct-toxin-exerts-diverse-functionalities-in-numerous-cells-an-overview
#4
REVIEW
Nidhi Chauhan, Alfred Chin Yen Tay, Barry J Marshall, Utkarsh Jain
BACKGROUND: Helicobacter pylori, gastric cancer-causing bacteria, survive in their gastric environment of more than 50% of the world population. The presence of H. pylori in the gastric vicinity promotes the development of various diseases including peptic ulcer and gastric carcinoma. H. pylori produce and secret Vacuolating cytotoxin A (VacA), a major toxin facilitating the bacteria against the host defense system. The toxin causes multiple effects in epithelial cells and immune cells, especially T cells, B cells, and Macrophages...
October 16, 2018: Helicobacter
https://www.readbyqxmd.com/read/30323101/disseminated-tuberculosis-caused-by-mycobacterium-bovis-presenting-as-a-tongue-base-mass
#5
Sarah Pratt, Arthur Henderson, Stuart Gillett
An 80-year-old woman presented with dysphagia, odynophagia and progressive weight loss. Initial investigations suggested a large base of tongue squamous cell carcinoma. At panendoscopy, biopsies were taken which revealed granulomatous inflammation with multinucleated giant cells and areas of caseous necrosis. Acid-fast bacilli were identified on Ziehl-Neelsen stain and the appearances were consistent with Mycobacterium bovis Closer inspection of the patient's medical history revealed that she had previously undergone right hemicolectomy for an ascending colon stricture...
October 14, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/30321984/emodin-sensitizes-hepatocellular-carcinoma-cells-to-the-anti-cancer-effect-of-sorafenib-through-suppression-of-cholesterol-metabolism
#6
Young-Seon Kim, Yoon-Mi Lee, Taek-In Oh, Dong Hoon Shin, Geon-Hee Kim, Sang-Yeon Kan, Hyeji Kang, Ji Hyung Kim, Byeong Mo Kim, Woo Jong Yim, Ji-Hong Lim
Reduced therapeutic efficacy of sorafenib, a first-generation multikinase inhibitor, is often observed during the treatment of advanced hepatocellular carcinoma (HCC). Emodin is an active component of Chinese herbs, and is effective against leukemia, lung cancer, colon cancer, pancreatic cancer, and HCC; however, the sensitizing effect of emodin on sorafenib-based HCC therapy has not been evaluated. Here, we demonstrate that emodin significantly improved the anti-cancer effect of sorafenib in HCC cells, such as HepG2, Hep3B, Huh7, SK-HEP-1, and PLC/PRF5...
October 12, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30321829/a-case-report-of-postoperative-vrsa-enteritis-effective-management-of-rifampicin-for-vancomycin-resistant-staphylococcus-aureus-enteritis-after-esophagectomy-and-colon-reconstruction
#7
Naoya Okada, Takeo Fujita, Jun Kanamori, Ataru Sato, Yasumasa Horikiri, Takuji Sato, Hisashi Fujiwara, Hiroyuki Daiko
INTRODUCTION: Vancomycin is one of the most widely used antibiotics for the treatment of serious infectious caused by methicillin-resistant Staphylococcus aureus (MRSA). However, reduced susceptibility of S. aureus to vancomycin has been observed in recent years. We report on a case of vancomycin resistant methicillin-resistant Staphylococcus aureus (VRSA) enteritis after colon reconstruction followed by esophagectomy and completion gastrectomy, with extended lymph node dissection for esophageal squamous cell carcinoma...
August 24, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/30320262/biological-evaluation-and-docking-studies-of-synthetic-oleanane-type-triterpenoids
#8
Mariano Ortega-Muñoz, Fernando Rodríguez-Serrano, Eduardo De Los Reyes-Berbel, Nuria Mut-Salud, Fernando Hernández-Mateo, Andrea Rodríguez-López, José M Garrido, F Javier López-Jaramillo, Francisco Santoyo-González
Saponins are potential wide-spectrum antitumor drugs, and copper(I) catalyzed azide-alkyne 1,3-dipolar cycloaddition is a suitable approach to synthesizing saponin-like compounds by regioselective glycosylation of the C2/C3 hydroxyl and C28 carboxylic groups of triterpene aglycones maslinic acid (MA) and oleanolic acid (OA). Biological studies on the T-84 human colon carcinoma cell line support the role of the hydroxyl groups at C2/C3, the influence of the aglycone, and the bulky nature of the substituents in C28...
September 30, 2018: ACS Omega
https://www.readbyqxmd.com/read/30319196/increased-nuclear-factor-%C3%AE%C2%BAb-rela-expression-levels-in-human-colorectal-carcinoma-in-north-indian-patients
#9
Ram Rattan Negi, Satya Vati Rana, Rajesh Gupta, Vikas Gupta, Vijayta D Chadha, Devinder K Dhawan
Colorectal cancer is a major cause of cancer-related death in many countries. Inflammatory pathway is considered to play a major role in colorectal carcinogenesis. Nuclear factor kappa B (NF-κB) pathway is a link between inflammation and cancer. NF-κB is a transcription factor which belongs to the Rel family. Activation of NF-κB has been shown to play a role in cell proliferation, apoptosis, cytokine production, and oncogenesis. The aim of the present study was to evaluate the expression levels of NF-κB/RelA in colorectal carcinoma using Real-time PCR...
October 2018: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/30317849/diagnostic-value-of-18-f-fdg-pet-ct-in-patients-with-carcinoma-of-unknown-primary
#10
Arzu Cengiz, Sibel Göksel, Yakup Yürekli
Objective: The aim of this study is to investigate the clinical role of 18 F-fluorodeoxyglucose (18 F-FDG) positron emission tomography/computed tomography (PET/CT) in patients with carcinoma of unknown primary (CUP). Methods: One hundred twenty one patients with a diagnosis of CUP who underwent whole body 18 F-FDG PET/CT imaging were included in this retrospective study. The final diagnoses were confirmed either histopathologically or by clinical follow-up. Results: The 18 F-FDG-PET/CT successfully detected the primary tumor in 59 out of 121 (49%) patients...
October 9, 2018: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/30315348/association-of-il-36%C3%AE-with-tertiary-lymphoid-structures-and-inflammatory-immune-infiltrates-in-human-colorectal-cancer
#11
Aliyah M Weinstein, Nicolas A Giraldo, Florent Petitprez, Catherine Julie, Laetitia Lacroix, Frédérique Peschaud, Jean-François Emile, Laetitia Marisa, Wolf H Fridman, Walter J Storkus, Catherine Sautès-Fridman
IL-1 family cytokines play a dual role in the gut, with different family members contributing either protective or pathogenic effects. IL-36γ is an IL-1 family cytokine involved in polarizing type-1 immune responses. However, its function in the gut, including in colorectal cancer pathogenesis, is not well appreciated. In a murine model of colon carcinoma, IL-36γ controls tertiary lymphoid structure formation and promotes a type-1 immune response concurrently with a decrease in expression of immune checkpoint molecules in the tumor microenvironment...
October 12, 2018: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/30314823/acth-secreting-neuroendocrine-carcinoma-of-the-cecum-case-report-and-review-of-the-literature
#12
Ahmed Mokhtar, Thomas Arnason, Daniel Gaston, Weei-Yuarn Huang, Heather MacKenzie, Rayan Al-Hazmi, Nadine Vaninetti, Barna Tugwell, Daniel Rayson
BACKGROUND: Approximately 30% of neuroendocrine tumors (NETs) present with secretory syndromes or develop one during the course of the disease. Cushing syndrome caused by a gastrointestinal tract NET is rare, with limited published information. We describe a patient with florid Cushing syndrome due to ectopic adrenocorticotropic hormone (ACTH) from a NET of colonic origin. A literature review was conducted to describe the spectrum of this clinical and pathologic entity as reported in the scientific literature...
August 11, 2018: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/30314491/wide-excision-and-reconstruction-surgery-for-recurrent-sweat-gland-umbilical-adenocarcinoma-followed-by-chemotherapy-can-prevent-the-risk-of-recurrences
#13
Adeodatus Yuda Handaya, Nova Yuli Prasetyo Budi, Guntur Marganing Adi Nugroho, Aditya Rifqi Fauzi
BACKGROUND: Adenocarcinoma derived from umbilicus is very rare. Most adenocarcinomas in umbilicus are secondary events. Carcinoma derived from sweat glands is sporadic, highly radioresistant and has a clinical appearance that is difficult to predict. CASE PRESENTATION: A 37-year-old woman presented with recurrent umbilicus adenocarcinoma after a history of umbilicus tumor surgery 14 months earlier and Capecitabine chemotherapy six times. Malignant cells were found in Fine Needle Aspiration Biopsy (FNAB) examination...
October 12, 2018: BMC Surgery
https://www.readbyqxmd.com/read/30312888/microcystin-lr-promotes-migration-via-the-cooperation-between-microrna-221-pten-and-stat3-signal-pathway-in-colon-cancer-cell-line-dld-1
#14
Yan Ren, Mengli Yang, Rong Ma, Ying Gong, Yuntao Zou, Ting Wang, Jianzhong Wu
Previous researches have reported that microcystin-LR (MC-LR) contributes to the progression of multiple types of carcinomas including colon cancer; however, the underlying molecular mechanisms remain unclear and require in-depth investigation. Here, the colon cell line DLD-1 was arranged for the analysis by the microRNA microarray which was associated with the cancer metastasis after MC-LR exposure. 31 human microRNAs were differentially expressed, including miR-221, which targeted 3'-UTR of PTEN mRNA and PTEN level was down-regulated by MC-LR treatment...
October 9, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/30312431/smoking-and-risk-of-colorectal-cancer-sub-classified-by-tumor-infiltrating-t-cells
#15
Tsuyoshi Hamada, Jonathan A Nowak, Yohei Masugi, David A Drew, Mingyang Song, Yin Cao, Keisuke Kosumi, Kosuke Mima, Tyler S Twombly, Li Liu, Yan Shi, Annacarolina da Silva, Mancang Gu, Wanwan Li, Katsuhiko Nosho, NaNa Keum, Marios Giannakis, Jeffrey A Meyerhardt, Kana Wu, Molin Wang, Andrew T Chan, Edward L Giovannucci, Charles S Fuchs, Reiko Nishihara, Xuehong Zhang, Shuji Ogino
Background: Evidence indicates not only carcinogenic effect of cigarette smoking but also its immunosuppressive effect. We hypothesized that the association of smoking with colorectal cancer risk might be stronger for tumors with lower anti-tumor adaptive immune response. Methods: During follow-up of 134 981 participants (3 490 851 person-years) in the Nurses' Health Study and Health Professionals Follow-up Study, we documented 729 rectal and colon cancer cases with available data on T-cell densities in tumor microenvironment...
October 11, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/30309962/discovery-of-a-small-molecule-inhibitor-of-specific-serine-residue-bad-phosphorylation
#16
Vijay Pandey, Baocheng Wang, Chakrabhavi Dhananjaya Mohan, Ainiah Rushdiana Raquib, Shobith Rangappa, Venkatachalaiah Srinivasa, Julian E Fuchs, Kesturu S Girish, Tao Zhu, Andreas Bender, Lan Ma, Zhinan Yin, Basappa, Kanchugarakoppal S Rangappa, Peter E Lobie
Human BCL-2-associated death promoter (hBAD) is an apoptosis-regulatory protein mediating survival signals to carcinoma cells upon phosphorylation of Ser99, among other residues. Herein, we screened multiple small-molecule databases queried in a Laplacian-modified naive Bayesian-based cheminformatics platform and identified a Petasis reaction product as a site-specific inhibitor for hBAD phosphorylation. Based on apoptotic efficacy against mammary carcinoma cells, N -cyclopentyl-3-((4-(2,3-dichlorophenyl) piperazin-1-yl) (2-hydroxyphenyl) methyl) benzamide (NPB) was identified as a potential lead compound...
October 11, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/30308276/local-delivery-of-a-cancer-favoring-oncolytic-vaccinia-virus-via-poly-lactic-co-glycolic-acid-nanofiber-for-theranostic-purposes
#17
Narayanasamy Badrinath, Young Il Jeong, Hyun Young Woo, Seo Young Bang, Chan Kim, Jeong Heo, Dae Hwan Kang, So Young Yoo
Local delivery of viruses via nanomaterials has been demonstrated in the treatment of colon cancer. A cancer-favoring oncolytic vaccinia virus (CVV), which is an evolutionary cancer-favoring engineered vaccinia virus carrying the green fluorescent protein (GFP) gene, has antitumor efficacy in drug-resistant colon cancer and metastatic liver cells. Here, we present the antitumor efficacy of a CVV coated a poly lactic-co-glycolic acid (PLGA) nanofiber for local drug delivery in theranostic approaches. In vitro- and in vivo-based analyses using mouse colon carcinoma models confirmed the therapeutic efficacy of CVV-PLGA nanofibers through diagnostic localization of the tumors and reduced tumor burden as a result of enhanced apoptosis...
October 9, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/30306293/purification-characterization-and-fine-sugar-specificity-of-a-n-acetylgalactosamine-specific-lectin-from-adenia-hondala
#18
Mamta Sharma, Prajna Hegde, Kavita Hiremath, Vishwanath Reddy H, A S Kamalanathan, Bale M Swamy, Shashikala R Inamdar
Plant lectins are gaining interest because of their interesting biological properties. Several Adenia species, that are being used in traditional medicine to treat many health ailments have shown presence of lectins or carbohydrate binding proteins. Here, we report the purification, characterization and biological significance of N-Acetyl galactosamine specific lectin from Adenia hondala (AHL) from Passifloraceae family. AHL was purified in a single step by affinity chromatography on asialofetuin Sepharose 4B column, characterized and its fine sugar specificity determined by glycan array analysis...
October 10, 2018: Glycoconjugate Journal
https://www.readbyqxmd.com/read/30304298/underwater-endoscopic-mucosal-resection-of-serrated-adenomas
#19
Dalton Marques Chaves, Hélcio Pedrosa Brito, Lumi Tomishige Chaves, Rodrigo Azevedo Rodrigues, Beatriz Mônica Sugai
OBJECTIVES: Serrated polyps, which are considered to be precursors of colorectal carcinoma, include hyperplastic polyps, sessile serrated adenomas and traditional serrated adenomas. With the exception of hyperplastic polyps, all of these lesions must be removed. This study sought to examine whether underwater endoscopic mucosal resection is a safe and effective technique for treating serrated polyps. METHODS: Cases in which patients were submitted for underwater endoscopic mucosal resection and histologically diagnosed with sessile serrated adenoma were prospectively registered...
October 8, 2018: Clinics
https://www.readbyqxmd.com/read/30304016/ovarian-stromal-cells-as-a-source-of-cancer-associated-fibroblasts-in-human-epithelial-ovarian-cancer-a-histopathological-study
#20
Masayoshi Fujisawa, Aye Moh-Moh-Aung, Zheng Zeng, Teizo Yoshimura, Yoji Wani, Akihiro Matsukawa
Fibroblasts are a major component of cancer tissue and known to contribute to cancer progression. However, it remains unknown whether they are derived from local fibroblasts or of other origin. This study was designed to identify the contribution of local stromal cells to cancer stroma in human epithelial ovarian cancer. Seventy-six cases of surgically resected primary ovarian carcinoma (48 cases confined to the ovaries and 28 cases with distant metastases) and 17 cases of secondary ovarian tumor (e.g. colon cancer metastasized to the ovary) were enrolled in this study...
2018: PloS One
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