keyword
https://read.qxmd.com/read/38630632/oxidized-sodium-alginate-hydrogel-mouse-nerve-growth-factor-sustained-release-system-promotes-repair-of-peripheral-nerve-injury
#21
JOURNAL ARTICLE
Yuming Sun, Xiangyu Sun, Ruiqi Wang, Yuhang Xing, Xiang Ma, Jie Yue, Min Zhang, Yuezhu Wang, Weiming Tian, Guangping Jing
In recent years, mouse nerve growth factor (mNGF) has emerged as an important biological regulator to repair peripheral nerve injury, but its systemic application is restricted by low efficiency and large dosage requirement. These limitations prompted us to search for biomaterials that can be locally loaded. Oxidized sodium alginate hydrogel (OSA) exhibits good biocompatibility and physicochemical properties, and can be loaded with drugs to construct a sustained-release system that can act locally on nerve injury...
April 17, 2024: Journal of Biomaterials Science. Polymer Edition
https://read.qxmd.com/read/38630361/neuroprotective-effect-of-withania-somnifera-leaves-extract-nanoemulsion-against-penconazole-induced-neurotoxicity-in-albino-rats-via-modulating-tgf-%C3%AE-1-smad2-signaling-pathway
#22
JOURNAL ARTICLE
Mohamed Abomosallam, Basma M Hendam, Amr A Abdallah, Rasha Refaat, Heba Nageh Gad El-Hak
Penconazole (PEN) is a systemic triazole fungicide used to control various fungal diseases on grapes, stone fruits, cucurbits, and strawberries. Still, it leaves residues on treated crops after collection with many hazardous effects on population including neurotoxicity. Withania somnifera leaves extract (WSLE) is known for its memory and brain function enhancing ability. To evoke such action efficiently, WSLE bioactive metabolites are needed to cross the blood-brain barrier, that could limit the availability of such compounds to be localized within the brain...
April 17, 2024: Inflammopharmacology
https://read.qxmd.com/read/38629102/bone-marrow-stromal-cell-conditioned-medium-regenerates-injured-sciatic-nerve-by-increasing-expression-of-mpz-and-ngf-and-decreasing-apoptosis
#23
JOURNAL ARTICLE
Mitra Ghasemi, Athar Talebi, Ali Ghanbari, Parisa Hayat, Behpour Yousefi, Moslem Mohammadi, Mahmood Abedinzade, Nooshin Ahmadirad, Sam Zarbakhsh
OBJECTIVES: Despite the many benefits of mesenchymal stem cell (MSC) transplantation for tissue regeneration, there are some limitations to using them, including the high costs, applying invasive procedures, the possibility of transplant rejection, and cell malignancy. This study aimed to investigate the effect of secretions of bone marrow stromal cells (BMSCs) with the cell-free strategy on damaged sciatic nerve with an emphasis on the role of apoptosis and the expression of myelin protein zero (MPZ) and nerve growth factor (NGF) proteins...
2024: Iranian Journal of Basic Medical Sciences
https://read.qxmd.com/read/38628571/ultra-low-frequency-magnetic-energy-focusing-for-highly-effective-wireless-powering-of-deep-tissue-implantable-electronic-devices
#24
JOURNAL ARTICLE
Yuanyuan Li, Zhipeng Chen, Yuxin Liu, Zijian Liu, Tong Wu, Yuanxi Zhang, Lelun Peng, Xinshuo Huang, Shuang Huang, Xudong Lin, Xi Xie, Lelun Jiang
The limited lifespan of batteries is a challenge in the application of implantable electronic devices. Existing wireless power technologies such as ultrasound, near-infrared light and magnetic fields cannot charge devices implanted in deep tissues, resulting in energy attenuation through tissues and thermal generation. Herein, an ultra-low frequency magnetic energy focusing (ULFMEF) methodology was developed for the highly effective wireless powering of deep-tissue implantable devices. A portable transmitter was used to output the low-frequency magnetic field (<50 Hz), which remotely drives the synchronous rotation of a magnetic core integrated within the pellet-like implantable device, generating an internal rotating magnetic field to induce wireless electricity on the coupled coils of the device...
May 2024: National Science Review
https://read.qxmd.com/read/38621948/-effects-of-tetramethylpyrazine-on-pharmacokinetics-in-plasma-and-brain-dialysate-and-neuropathic-pain-in-rat-model-of-spared-sciatic-nerve-injury
#25
JOURNAL ARTICLE
Zhi Chen, Dan-Dan DU, Ya Gao, Jun-Miao Chen, Cui-Ping Wei, Xiao-Gang Weng, Jian Sun, Xin-Yuan Wang, Zhi-Guo Wang, Mei-Yu Zhang
This study aims to explore the effects of tetramethylpyrazine(TMP) on pharmacokinetics in plasma and brain dialysate and neuropathic pain in the rat model of partial sciatic nerve injury(SNI), and to investigate the correlation between the analgesic effect of TMP and its concentrations in the plasma and brain dialysate. Male SD rats were randomized into Sham, SNI, and SNI+TMP groups. Mechanical stimulation with von frey filaments and cold spray method were employed to evaluate the mechanical sensitivity and cold sensitivity of rats...
March 2024: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://read.qxmd.com/read/38621666/evaluating-stromal-vascular-fraction-as-a-treatment-for-peripheral-nerve-regeneration-a-scoping-review
#26
REVIEW
Tyler Jacobs, Connor Mahoney, Saad Mohammed, Vincent Ziccardi
PURPOSE: This study aims to investigate the potential of stromal vascular fraction (SVF) for peripheral nerve regeneration. METHODS: A scoping review of Scopus and PubMed databases was conducted. Inclusion criteria were human or animal studies exploring the use of SVF for peripheral nerve regeneration. Studies were categorized by assessed outcomes: pain assessment, neural integrity, muscle recovery, and functional recovery. Level of evidence and study quality were assessed...
March 28, 2024: Journal of Oral and Maxillofacial Surgery
https://read.qxmd.com/read/38621303/phantom-limb-pain-traumatic-neuroma-or-nerve-sheath-tumor-illustrative-case
#27
JOURNAL ARTICLE
Patrick J Halloran, E Antonio Chiocca, Andres Santos
BACKGROUND: Phantom limb pain and traumatic neuromas are not commonly seen in neurosurgical practice. These conditions can present with similar symptoms; however, management of traumatic neuroma is often surgical, whereas phantom limb pain is treated with conservative measures. OBSERVATIONS: A 77-year-old female patient with a long-standing history of an above-the-knee amputation experienced severe pain in her right posterior buttocks area for several years' duration, attributed to phantom limb pain, which radiated down the stump of her leg and was treated with a variety of conservative measures...
April 15, 2024: J Neurosurg Case Lessons
https://read.qxmd.com/read/38618174/nerve-preparation-and-recordings-for-pharmacological-tests-of-sensory-and-nociceptive-fiber-conduction-ex-vivo
#28
JOURNAL ARTICLE
Volodymyr Krotov, Olga Kopach
Measuring signal propagation through nerves is a classical electrophysiological technique established decades ago to evaluate sensory and motor functions in the nervous system. The whole-nerve preparation provides a valuable model to investigate nerve function ex vivo; however, it requires specific knowledge to ensure successful and stable measurements. Although the methodology for sciatic nerve recordings has long existed, a method for reliable and long-lasting recordings from myelinated and non-myelinated (nociceptive) fibers still needs to be adapted for pharmacological testing...
April 5, 2024: Bio-protocol
https://read.qxmd.com/read/38615504/neurogenic-heterotopic-ossification-of-the-hip-magnetic-resonance-imaging-versus-computed-tomography-for-pre-surgical-assessment
#29
JOURNAL ARTICLE
Raphaël Amar, Marjorie Salga, Mickaël Tordjman, Nadia Venturelli, Lionelle Nkam, Madalina Jacota, Lamiae Grimaldi-Bensouda, Fabien Cale, Robert-Yves Carlier
PURPOSE: Neurogenic heterotopic ossification (NHO) of the hip is a frequent complication of spinal cord injuries, often requiring surgical management. Pre-surgical imaging assessment is essential, usually with computed tomography (CT)-scan. We aimed to compare magnetic resonance imaging (MRI) and CT for pre-surgical imaging assessment of the NHO, particularly for their relationships with vessels and nerves. METHOD: This prospective study included consecutive patients who underwent surgery for NHO from July 2019 to April 2022...
April 10, 2024: European Journal of Radiology
https://read.qxmd.com/read/38612497/fibrin-glue-coating-limits-scar-tissue-formation-around-peripheral-nerves
#30
JOURNAL ARTICLE
Maximilian Mayrhofer-Schmid, Martin Aman, Adriana C Panayi, Floris V Raasveld, Ulrich Kneser, Kyle R Eberlin, Leila Harhaus, Arne Böcker
Scar tissue formation presents a significant barrier to peripheral nerve recovery in clinical practice. While different experimental methods have been described, there is no clinically available gold standard for its prevention. This study aims to determine the potential of fibrin glue (FG) to limit scarring around peripheral nerves. Thirty rats were divided into three groups: glutaraldehyde-induced sciatic nerve injury treated with FG (GA + FG), sciatic nerve injury with no treatment (GA), and no sciatic nerve injury (Sham)...
March 26, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38611670/ultrasound-guided-sciatic-nerve-hydrodissection-can-improve-the-clinical-outcomes-of-patients-with-deep-gluteal-syndrome-a-case-series-study
#31
JOURNAL ARTICLE
Yun-Shan Yen, Chang-Hao Lin, Chen-Hao Chiang, Cheng-Yi Wu
Deep gluteal syndrome (DGS) is caused by sciatic nerve entrapment. Because fascial entrapment neuropathies may occur in multiple locations, ultrasound-guided nerve hydrodissection is a key component of DGS treatment. In this study, we examined the clinical outcomes of patients with DGS undergoing ultrasound-guided sciatic nerve hydrodissection. A 10 mL mixture consisting of 5% dextrose, 0.2% lidocaine (Xylocaine), and 4 mg betamethasone (Rinderon) was used for nerve hydrodissection. Clinical outcomes were evaluated using Numeric Rating Scale (NRS) scores of pain, the proportion of patients with favorable outcomes (reduction of ≥50% in pain), the duration for which patients exhibited favorable outcomes (percentage of follow-up duration), and the occurrence of major complications and minor side effects...
April 2, 2024: Diagnostics
https://read.qxmd.com/read/38611609/the-association-between-anatomical-variants-of-musculoskeletal-structures-and-nerve-compressions-of-the-lower-limb-a-systematic-review-and-meta-analysis
#32
REVIEW
Juan José Valenzuela-Fuenzalida, Alfredo Inostroza-Wegner, Francisca Osorio-Muñoz, Daniel Milos-Brandenberg, Andres Santana-Machuca, Pablo Nova Baeza, Mathias Orellana Donoso, Alejandro Bruna-Mejias, Joe Iwanaga, Juan Sanchis-Gimeno, Hector Gutierrez-Espinoza
Objective: The aim of this study was to describe the main anatomical variants and morphofunctional alterations in the lower limb that compress surrounding nervous structures in the gluteal region, thigh region, and leg and foot region. Methods: We searched the Medline, Scopus, Web of Science, Google Scholar, CINAHL, and LILACS databases from their inception up to October 2023. An assurance tool for anatomical studies (AQUA) was used to evaluate methodological quality, and the Joanna Briggs Institute assessment tool for case reports was also used...
March 26, 2024: Diagnostics
https://read.qxmd.com/read/38610888/anatomical-safety-area-for-periarticular-analgesic-infiltration-through-the-posterior-capsule-in-total-knee-arthroplasty-radiological-study-in-magnetic-resonance
#33
JOURNAL ARTICLE
Marta Mifsut-Aleixandre, Damián Mifsut, Eva María González-Soler, Arantxa Blasco-Serra, Alfonso Amador Valverde
Background : One of the main challenges of orthopedic surgery is adequate pain management after total knee arthroplasty. This work aimed to determine the anatomical safety area for infiltration through the posterior capsule of the knee in prosthetic surgery using Magnetic Resonance Imaging (MRI). Methods : A descriptive, observational, cross-sectional study was performed on 126 knee MRIs. The variables studied were age, sex, and distance between different neurovascular structures of the popliteal fossa (tibial nerve, common peroneal nerve, and vascular bundle)...
April 6, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38604162/pulsed-electromagnetic-field-assisted-reduced-graphene-oxide-composite-3d-printed-nerve-scaffold-promotes-sciatic-nerve-regeneration-in-rats
#34
JOURNAL ARTICLE
Zichao Wang, Shijun Li, Zongxi Wu, Yifan Kang, Shang Xie, Zhigang Cai, Xiaofeng Shan, Qing Li
Peripheral nerve injuries can lead to sensory or motor deficits that have a serious impact on a patient's mental health and quality of life. Nevertheless, it remains a major clinical challenge to develop functional nerve conduits as an alternative to autologous grafts. We applied reduced graphene oxide (rGO) as a bioactive conductive material to impart electrophysiological properties to the catheter and the application of a pulsed magnetic field to excite the formation of microcurrents and induce nerve regeneration...
April 11, 2024: Biofabrication
https://read.qxmd.com/read/38599367/rejuvenating-fecal-microbiota-transplant-enhances-peripheral-nerve-repair-in-aged-mice-by-modulating-endoneurial-inflammation
#35
JOURNAL ARTICLE
Martin K R Svačina, Tong Gao, Alina Sprenger-Svačina, Jianxin Lin, Bhanu P Ganesh, Juneyoung Lee, Louise D McCullough, Kazim A Sheikh, Gang Zhang
Peripheral nerve injury (PNI) resulting from trauma or neuropathies can cause significant disability, and its prognosis deteriorates with age. Emerging evidence suggests that gut dysbiosis and reduced fecal short-chain fatty acids (SCFAs) contribute to an age-related systemic hyperinflammation (inflammaging), which hinders nerve recovery after injury. This study thus aimed to evaluate the pro-regenerative effects of a rejuvenating fecal microbiota transplant (FMT) in a preclinical PNI model using aged mice...
April 9, 2024: Experimental Neurology
https://read.qxmd.com/read/38598278/dental-pulp-stem-cell-derived-exosomes-promote-sciatic-nerve-regeneration-via-optimizing-schwann-cell-function
#36
JOURNAL ARTICLE
Ying Chai, Yuemin Liu, Zhiyang Liu, Wenbin Wei, Yabing Dong, Chi Yang, Minjie Chen
Repair strategies for injured peripheral nerve have achieved great progresses in recent years. However, the clinical outcomes remain unsatisfactory. Recent studies have found that exosomes secreted by dental pulp stem cells (DPSC-exos) have great potential for applications in nerve repair. In this study, we evaluated the effects of human DPSC-exos on improving peripheral nerve regeneration. Initially, we established a coculture system between DPSCs and Schwann cells (SCs) in vitro to assess the effect of DPSC-exos on the activity of embryonic dorsal root ganglion neurons (DRGs) growth in SCs...
April 10, 2024: Cellular Reprogramming
https://read.qxmd.com/read/38591541/n-cadherin-directs-the-collective-schwann-cell-migration-required-for-nerve-regeneration-through-slit2-3-mediated-contact-inhibition-of-locomotion
#37
JOURNAL ARTICLE
Julian J A Hoving, Elizabeth Harford-Wright, Patrick Wingfield-Digby, Anne-Laure Cattin, Mariana Campana, Alex Power, Toby Morgan, Erica Torchiaro, Victor Quereda, Alison C Lloyd
Collective cell migration is fundamental for the development of organisms and in the adult, for tissue regeneration and in pathological conditions such as cancer. Migration as a coherent group requires the maintenance of cell-cell interactions, while contact inhibition of locomotion (CIL), a local repulsive force, can propel the group forward. Here we show that the cell-cell interaction molecule, N-cadherin, regulates both adhesion and repulsion processes during rat Schwann cell (SC) collective migration, which is required for peripheral nerve regeneration...
April 9, 2024: ELife
https://read.qxmd.com/read/38591338/sexually-dimorphic-effects-of-pexidartinib-on-nerve-injury-induced-neuropathic-pain-in-mice
#38
JOURNAL ARTICLE
Fumihiro Saika, Yohji Fukazawa, Yu Hatano, Shiroh Kishioka, Yuko Hino, Shinjiro Hino, Kentaro Suzuki, Norikazu Kiguchi
It is well-established that spinal microglia and peripheral macrophages play critical roles in the etiology of neuropathic pain; however, growing evidence suggests sex differences in pain hypersensitivity owing to microglia and macrophages. Therefore, it is crucial to understand sex- and androgen-dependent characteristics of pain-related myeloid cells in mice with nerve injury-induced neuropathic pain. To deplete microglia and macrophages, pexidartinib (PLX3397), an inhibitor of the colony-stimulating factor 1 receptor, was orally administered, and mice were subjected to partial sciatic nerve ligation (PSL)...
April 9, 2024: Glia
https://read.qxmd.com/read/38590761/cholesterol-dependent-lxr-transcription-factor-activity-represses-pronociceptive-effects-of-estrogen-in-sensory-neurons-and-pain-induced-by-myelin-basic-protein-fragments
#39
JOURNAL ARTICLE
Swathi K Hullugundi, Jennifer Dolkas, Andrei V Chernov, Tony L Yaksh, Kelly A Eddinger, Mila Angert, Glaucilene Ferreira Catroli, Alex Y Strongin, Patrick M Dougherty, Yan Li, Oswal Quehenberger, Aaron Armando, Veronica I Shubayev
BACKGROUND: A bioactive myelin basic protein (MBP) fragment, comprising MBP84-104 , is released in sciatic nerve after chronic constriction injury (CCI). Intraneural injection (IN) of MBP84-104 in an intact sciatic nerve is sufficient to induce persistent neuropathic pain-like behavior via robust transcriptional remodeling at the injection site and ipsilateral dorsal root ganglia (DRG) and spinal cord. The sex (female)-specific pronociceptive activity of MBP84-104 associates with sex-specific changes in cholesterol metabolism and activation of estrogen receptor (ESR)1 signaling...
July 2024: Brain, behavior, & immunity health
https://read.qxmd.com/read/38590640/endurance-exercise-has-a-negative-impact-on-the-onset-of-sod1-g93a-als-in-female-mice-and-affects-the-entire-skeletal-muscle-motor-neuron-axis
#40
JOURNAL ARTICLE
Silvia Scaricamazza, Valentina Nesci, Illari Salvatori, Gianmarco Fenili, Marco Rosina, Michela Gloriani, Maria Paola Paronetto, Luca Madaro, Alberto Ferri, Cristiana Valle
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a fatal neuromuscular disease characterized by the degeneration of motor neurons that leads to muscle wasting and atrophy. Epidemiological and experimental evidence suggests a causal relationship between ALS and physical activity (PA). However, the impact of PA on motor neuron loss and sarcopenia is still debated, probably because of the heterogeneity and intensities of the proposed exercises. With this study, we aimed to clarify the effect of intense endurance exercise on the onset and progression of ALS in the SOD1-G93A mouse model...
2024: Frontiers in Pharmacology
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