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Emergency system

Leah C Davis, Timothy G Baumer, Michael J Bey, Marnix van Holsbeeck
Shear wave elastography (SWE) is an emerging technology that provides information about the inherent elasticity of tissues by producing an acoustic radiofrequency force impulse, sometimes called an "acoustic wind," which generates transversely-oriented shear waves that propagate through the surrounding tissue and provide biomechanical information about tissue quality. Although SWE has the potential to revolutionize bone and joint imaging, its clinical application has been hindered by technical and artifactual challenges...
August 23, 2018: Ultrasonography
E Brooke Lerner, Jonathan R Studnek, Nicole Fumo, Anjishnu Banerjee, Igli Arapi, Lorin R Browne, Daniel G Ostermayer, Stacy Reynolds, Manish I Shah
BACKGROUND: Although all emergency departments (ED) should be ready to treat children, some may have illnesses or injuries that require higher-level pediatric resources that are not available at all hospitals. There are no national guidelines for EMS providers about when to directly transport children to hospitals with higher-level pediatric resources, with the exception of severe trauma. Variability exists in EMS protocols about when children warrant transport to hospitals with higher-level pediatric care...
October 21, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
Cecilia Granéli, Ryan Hicks, Gabriella Brolén, Jane Synnergren, Peter Sartipy
The global burden of diabetes has drastically increased over the past decades and in 2017 approximately 4 million deaths were caused by diabetes and cardiovascular complications. Diabetic cardiomyopathy is a common complication of diabetes with early manifestations of diastolic dysfunction and left ventricular hypertrophy with subsequent progression to systolic dysfunction and ultimately heart failure. An in vitro model accurately recapitulating key processes of diabetic cardiomyopathy would provide a useful tool for investigations of underlying disease mechanisms to further our understanding of the disease and thereby potentially advance treatment strategies for patients...
October 20, 2018: Stem Cell Reviews
Gee Su Yang, Sreelakshmy Kumar, Susan G Dorsey, Angela R Starkweather, Debra Lynch Kelly, Debra E Lyon
PURPOSE: Psychoneurological (PN) symptoms, such as anxiety, cognitive impairment, depression, fatigue, sleep disturbances, and pain, are highly prevalent in breast cancer patients undergoing cancer treatment. Emerging evidence suggests that genetic polymorphisms may contribute to differential symptom susceptibility. We aimed to systematically review associations between genetic polymorphisms and PN symptoms during or after cancer treatment for early-stage breast cancer. METHODS: Twenty-six eligible articles published until October 2017 were identified in PubMed, PsycINFO, Web of Science, and additional records...
October 20, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Kasra Kamali, Ali Taravati, Shayan Sayyadi, Fatemeh Zahra Gharib, Houman Maftoon
Exposure to electromagnetic radiation (EMR) is rapidly increasing in everyday environment, consequently conferring potential health effects. Oxidative stress is emerging as a mechanism implicated in pathophysiology and progression of various diseases. To our knowledge, no report has been made on the status of antioxidant redox systems after continuous exposure to radiofrequency radiation emitted from a Wi-Fi access point in animal model so far. Therefore, we aimed to continuously subject rats in the experimental group to radiofrequency (RF) radiation emitted from a commercially available Wi-Fi device...
October 21, 2018: Environmental Science and Pollution Research International
Masashi Watanave, Chiaki Hoshino, Ayumu Konno, Yumi Fukuzaki, Yasunori Matsuzaki, Tohru Ishitani, Hirokazu Hirai
Cerebellar Purkinje cells (PCs) are the sole output neurons of the cerebellar cortex, and damage to PCs results in motor deficits. Spinocerebellar ataxia type 3 (SCA3, also known as Machado-Joseph disease), a hereditary neurodegenerative disease, is caused by an abnormal expansion of the polyglutamine tract in the causative ATXN3 protein. SCA3 affects a wide range of cells in the central nervous system, including those in the cerebellum. To unravel SCA3 pathology, we used adeno-associated virus serotype 9 (AAV9) vectors to express full-length ATXN3 with an abnormally expanded 89 polyglutamine stretch (ATXN3[Q89]) in cerebellar neurons of mature wild-type mice...
October 18, 2018: Neurobiology of Disease
Ruijie K Zhang, Xiongyi Huang, Frances H Arnold
CH functionalization is an attractive strategy to construct and diversify molecules. Heme proteins, predominantly cytochromes P450, are responsible for an array of CH oxidations in biology. Recent work has coupled concepts from synthetic chemistry, computation, and natural product biosynthesis to engineer heme protein systems to deliver products with tailored oxidation patterns. Heme protein catalysis has been shown to go well beyond these native reactions and now accesses new-to-nature CH transformations, including CN and CC bond forming processes...
October 18, 2018: Current Opinion in Chemical Biology
Akiko Nakai, Kazuhiro Suzuki
Since the beginning of the last century, substantial evidence has suggested that various aspects of the immune system are influenced by the activity of the nervous system. However, the cellular and molecular basis for the neural control of immune responses has emerged only in the past decade. Recent studies have shown that adrenergic nerves control trafficking of immune cells through cell-type-specific mechanisms. Activation of the β2 -adrenergic receptor expressed on lymphocytes enhances signals mediated by a particular set of chemokine receptors, and consequently inhibits their exit from lymph nodes...
October 18, 2018: Neurochemistry International
Shveta Sethi, Ratnakar Shukla, Kiran Bala, Vikas Gautam, Archana Angrup, Pallab Ray
BACKGROUND: Bacteroides spp., an anaerobic resident intestinal flora is also known to cause severe morbidity. They are resistant to a wide variety of antimicrobial agents including metronidazole. Specific nitroimidazole (nim) resistance genes have been shown to be associated with the same. Worldwide, metronidazole resistance is emerging, though presently remains around 5%. This study was aimed at metronidazole susceptibility and distribution of nim genes within the Bacteroides spp. We also analyzed the relationship among the strains harboring nim genes and their susceptibility to metronidazole...
October 18, 2018: Journal of Global Antimicrobial Resistance
Krishani Dinali Perera, Anushka C Galasiti Kankanamalage, Athri D Rathnayake, Amanda Honeyfield, William Groutas, Kyeong-Ok Chang, Yunjeong Kim
Ferret and mink coronaviruses typically cause catarrhal diarrhea in ferrets and minks, respectively. In recent years, however, systemic fatal coronavirus infection has emerged in ferrets, which resembles feline infectious peritonitis (FIP) in cats. FIP is a highly fatal systemic disease caused by a virulent feline coronavirus infection in cats. Despite the importance of coronavirus infections in these animals, there are no effective commercial vaccines or antiviral drugs available for these infections. We have previously reported the efficacy of a protease inhibitor in cats with FIP, demonstrating that a virally encoded 3C-like protease (3CLpro) is a valid target for antiviral drug development for coronavirus infections...
October 18, 2018: Antiviral Research
Sanket Kumar Shukla, Khadija Rafiq
The ubiquitin proteasome system (UPS) is the major pathway for intracellular protein degradation in most organs, including the heart. UPS controls many fundamental biological processes such as cell cycle, cell division, immune responses, antigen presentation, apoptosis, and cell signaling. The UPS not only degrades substrates but also regulates activity of gene transcription at the post-transcription level. Emerging evidence suggests that impairment of UPS function is sufficient to cause a number of cardiac diseases, including heart failure, cardiomyopathies, hypertrophy, atrophy, ischemia-reperfusion, and atherosclerosis...
September 28, 2018: Translational Research: the Journal of Laboratory and Clinical Medicine
Laetitia Nebot-Bral, Clelia Coutzac, Patricia L Kannouche, Nathalie Chaput
In the last few years, immunotherapy has revolutionized the oncology landscape by targeting the host immune system. Blocking immune checkpoints such as cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), programmed cell death-1 (PD-1) and its ligand (PD-L1 or B7-H1), has proven its efficacy in several solid cancers. Recently, several clinical studies have demonstrated a significant improvement in clinical response to the anti-PD-1-based immunotherapy in a subset of patients with microsatellite instability-high (MSI-H)/mismatch repair (MMR)-deficient tumors that accumulate short insertion/deletion mutations notably in coding microsatellites regions of the genome...
October 17, 2018: Bulletin du Cancer
Hajar Mozaffar, Robin Williams, Kathrin Cresswell, Aziz Sheikh
CONTEXT: Despite widespread efforts to improve the quality and safety of healthcare through use of hospital information systems (HIS), many healthcare organizations face challenges in implementation and effective use of these applications, in particular when systems have been developed internationally (mainly in the US). Suppliers of these technologies also find it challenging to produce systems that work effectively across a range of geographical, cultural and institutional boundaries...
November 2018: International Journal of Medical Informatics
Sinan Ates, Mahmut Alp Karahan, Nuray Altay, Kazim Akelci, Nagehan Ikiz, Bulent Guzel, Mandeley Wilhelmina Ozer, Haci Durmus Yilmaz
OBJECTIVE: Scorpion stings remain a serious health problem in many parts of the world. There is very limited information regarding the effects of therapies delivered for scorpion stings in pregnant women on the mother and fetus. They can cause acute conditions such as fetal loss, preterm delivery, or placental abnormalities and can also result in other conditions that may have an effect on the baby in the long term. MATERIALS AND METHODS: In this study the medical records of 24 pregnant women who were admitted to the emergency room at Suruç State Hospital due to scorpion stings between January 1, 2013 and January 1, 2014 were retrospectively reviewed...
October 2018: Taiwanese Journal of Obstetrics & Gynecology
Annie E Moroco, Johnathan D McGinn
Systemic diseases commonly managed by the Internist may have presentations within the head and neck. Awareness of these manifestations, sometimes as the presenting signs or symptoms of systemic disease, may aid the Internist in diagnosis and management. The Otolaryngologist may be helpful in assisting in the evaluation of these patients and in some cases providing targeted symptomatic therapy. Some systemic processes can generate emergent airway events, and early engagement of the otolaryngologist is of value...
November 2018: Medical Clinics of North America
Tarun Pant, Anuradha Dhanasekaran, Juan Fang, Xiaowen Bai, Zeljko J Bosnjak, Mingyu Liang, Zhi-Dong Ge
Long noncoding RNAs (lncRNAs) are endogenous RNA transcripts longer than 200 nucleotides which regulate epigenetically the expression of genes but do not have protein-coding potential. They are emerging as potential key regulators of diabetes mellitus and a variety of cardiovascular diseases. Diabetic cardiomyopathy (DCM) refers to diabetes mellitus-elicited structural and functional abnormalities of the myocardium, beyond that caused by ischemia or hypertension. The purpose of this review was to summarize current status of lncRNA research for DCM and discuss the challenges and possible strategies of lncRNA research for DCM...
October 20, 2018: BMC Cardiovascular Disorders
Frédéric A Perras, Marek Pruski
Magic-angle-spinning (MAS) dynamic nuclear polarization (DNP) has recently emerged as a powerful technology enabling otherwise unrealistic solid-state NMR experiments. The simulation of DNP processes which might, for example, aid in refining the experimental conditions or the design of better performing polarizing agents, is, however, plagued with significant challenges, often limiting the system size to only 3 spins. Here, we present the first approach to fully ab initio large-scale simulations of MAS DNP enhancements...
October 21, 2018: Journal of Chemical Physics
Åsa Wahlberg, Ulf Högberg, Maria Emmelin
BACKGROUND: It is known that healthcare providers might be affected by severe medical events in which patients are badly hurt. In birth care, escalating situations can result in death or injury to a mother or new-born child. OBJECTIVE: To explore the process that Swedish midwives and obstetricians go through after a severe event in the maternity unit. DESIGN: A modified Constructivist Grounded Theory analysis, based on fourteen in-depth interviews with birth care professionals...
August 12, 2018: International Journal of Nursing Studies
Pavan Walvekar, Ramesh Gannimani, Thirumala Govender
Current drug therapy against infections is threatening to become obsolete due to the poor physical, chemical, biological and pharmacokinetic properties of drugs, followed by high risk of acquiring resistance. Taking into account the significant benefits of nanotechnology, nano-based delivery of anti-infectious agents is emerging as a potential approach to combat several lethal infections. Co-delivery of multiple anti-infectious agents in a single nano-based system is beginning to show significant advantages over mono-therapy, such as synergism, enhanced anti-microbial activity, broad anti-microbial spectrum, reduced resistance development, and improved and cost-effective treatment...
October 17, 2018: European Journal of Pharmaceutical Sciences
Ramesh Kumar, Divendu Bhushan, Mukesh Kumar
A 24-year-old male who presented to our emergency department with the history of having ingested mercury due to accidental breakage of the tip of mercury thermometer. He had 3 bouts of vomiting following ingestion; however, mercury beads were not seen in the vomitus. On admission, the patient was clinically stable, and his physical and systemic examinations were unremarkable. His routine investigations which included complete blood count, liver function test, kidney function tests, coagulation profiles, blood glucose, and electrocardiogram were normal...
January 2018: Journal of the Association of Physicians of India
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