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JOURNAL ARTICLE
Fayez Kheir, Juan Pablo Uribe Becerra, Brittany Bissell, Marya Ghazipura, Derrick Herman, Stephanie M Hon, Tanzib Hossain, Yet H Khor, Shandra L Knight, Michael Kreuter, Madalina Macrea, Manoj J Mammen, Fernando J Martinez, Venerino Poletti, Lauren Troy, Ganesh Raghu, Kevin C Wilson
Background: Usual interstitial pneumonia (UIP) is the histopathologic hallmark of idiopathic pulmonary fibrosis (IPF), the prototypical interstitial lung disease (ILD). Diagnosis of IPF requires that a typical UIP pattern be identified by using high-resolution chest computed tomography or lung sampling. A genomic classifier for UIP has been developed to predict histopathologic UIP by using lung samples obtained through bronchoscopy. Objective: To perform a systematic review to evaluate genomic classifier testing in the detection of histopathologic UIP to inform new American Thoracic Society, European Respiratory Society, Japanese Respiratory Society, and Asociación Latinoamericana del Tórax guidelines...
May 2022: Annals of the American Thoracic Society
#22
JOURNAL ARTICLE
Rubén Monárrez, Mitchell G Maltenfort, Andrew Figoni, Hannah J Szapary, Antonia F Chen, Erik N Hansen, Michael M Kheir
BACKGROUND: Preoperative calculation of treatment failure risk in patients undergoing surgery for periprosthetic joint infection (PJI) is imperative to allow for medical optimization and targeted prevention. A preoperative prognostic model for PJI treatment failure was previously developed, and this study sought to externally validate the model. METHODS: A retrospective review was performed of 380 PJIs treated at two institutions. The model was used to calculate the risk of treatment failure, and receiver operating characteristic curves were generated to calculate the area under the curve (AUC) for each institution...
July 2021: Journal of Arthroplasty
#23
MULTICENTER STUDY
Michael M Kheir, Julian E Dilley, Mary Ziemba-Davis, R Michael Meneghini
BACKGROUND: Surgical and host factors predispose patients to periprosthetic joint infection (PJI) after primary total hip arthroplasty (THA) and total knee arthroplasty (TKA). While surgical factors are modifiable, host factors can be challenging, and there are limited data demonstrating that preoperative patient optimization decreases risk of PJI. The goal of this study was to evaluate whether extended oral antibiotic prophylaxis reduces the one-year infection rate in high-risk patients...
July 2021: Journal of Arthroplasty
#24
REVIEW
Farah Ballout, Reem Daouk, Joseph Azar, Michael Timonian, Tarek Araji, Hisham F Bahmad, Wassim Abou-Kheir
Coronavirus disease 2019 (COVID-19) has infected millions of people worldwide and emerged to be the biggest global health threat claiming hundreds of thousands of lives at exponential rates. The severity of the disease increases with old age and presence of underlying health conditions, such as cancer. Managing cancer patients under these circumstances is rather challenging, given their compromised immunity and the overwhelmed health care services by COVID-19 community transmission. Thus, it is prudent to establish common guidelines for the monitoring and treatment of cancer patients...
2020: SN comprehensive clinical medicine
#25
JOURNAL ARTICLE
Michael Levy, Myriam Aouiti Trabelsi, Muhamed-Kheir Taha
The description of invasive meningococcal disease that is provoked by Neisseria meningitidis (Nm) is frequently restricted to meningitis. However, a wide panel of clinical presentations can be encountered including severe forms with intense inflammatory reaction leading to multi-organ failure. Several human factors are involved in the development of invasive infections such as transferrin, factor H or CEACAM1. In this study, we used an experimental meningococcal infection in transgenic mice expressing the human transferrin to show multi-organ infection...
September 23, 2020: Microorganisms
#26
REVIEW
Michael M Kheir, Timothy L Tan, Alexander J Rondon, Antonia F Chen
INTRODUCTION: Orthopaedic surgery residency has become increasingly competitive for medical school applicants with at least one in five applicants not matching annually. For unmatched applicants, the new application cycle is a perplexing and disconcerting period, where unique decisions must be addressed by the applicant. We aimed to investigate the risk factors and outcomes of unmatched orthopaedic applicants. METHODS: This was a retrospective study using a survey-based questionnaire administered electronically to medical students annually from 2016 to 2019 immediately after match day...
April 2020: JB & JS Open Access
#27
JOURNAL ARTICLE
Michael M Kheir
No abstract text is available yet for this article.
July 27, 2020: Clinical Orthopaedics and related Research
#28
JOURNAL ARTICLE
Michael M Kheir, Nicholas J Drayer, Antonia F Chen
No abstract text is available yet for this article.
July 28, 2020: Journal of Bone and Joint Surgery. American Volume
#29
JOURNAL ARTICLE
Carla J Guthridge, Timothy Gross, Magdalene Quintero, Joseph M Kheir, Jeremy Levin, Rebecka L Bourn, Sohail Khan, Michael Peercy, Bobby Saunkeah, Joel M Guthridge, Judith A James
OBJECTIVE: Many Native American (NA) patients with systemic lupus erythematosus (SLE) do not exhibit the classical SLE autoantibody profiles of European American (EA) and African American (AA) patients with SLE. The poorer SLE disease outcomes noted in NA patients highlights a need for more equitable diagnostic and prognostic tools for NA patients with SLE. The objective was to identify informative autoantibody profiles for NA, AA, and EA patients with SLE using an expanded set of autoantigens...
June 22, 2020: ACR open rheumatology
#30
JOURNAL ARTICLE
Erik E Folch, Gonzalo Labarca, Daniel Ospina-Delgado, Fayez Kheir, Adnan Majid, Sandeep J Khandhar, Hiren J Mehta, Michael A Jantz, Sebastian Fernandez-Bussy
BACKGROUND: Bronchoscopy is a useful tool for the diagnosis of lesions near central airways; however, the diagnostic accuracy of these procedures for peripheral pulmonary lesions (PPLs) is a matter of ongoing debate. In this setting, electromagnetic navigation bronchoscopy (ENB) is a technique used to navigate and obtain samples from these lesions. This systematic review and meta-analysis aims to explore the sensitivity of ENB in patients with PPLs suspected of lung cancer. RESEARCH QUESTION: In patients with peripheral pulmonary lesion suspected of lung cancer, what is the sensitivity and safety of electromagnetic navigation bronchoscopy compared to surgery or longitudinal follow up? STUDY DESIGN AND METHODS: A comprehensive search of several databases was performed...
October 2020: Chest
#31
RANDOMIZED CONTROLLED TRIAL
Fayez Kheir, Sanket Thakore, Hiren Mehta, Michael Jantz, Mihir Parikh, Alex Chee, Upendra Kaphle, Carlos Sisnega, Sebastian Fernandez-Bussy, Adnan Majid
Rationale: Pleural infection is frequently encountered in clinical practice and is associated with high morbidity and mortality. Limited evidence exists regarding the optimal treatment. Although both early medical thoracoscopy (MT) and tube thoracostomy with intrapleural instillation of tissue plasminogen activator and human recombinant deoxyribonuclease are acceptable treatments for patients with complicated pleural infection, there is a lack of comparative data for these modes of management. Objectives: The aim of this study was to compare the safety and efficacy of early MT versus intrapleural fibrinolytic therapy (IPFT) in selected patients with multiloculated pleural infection and empyema...
August 2020: Annals of the American Thoracic Society
#32
JOURNAL ARTICLE
Ido Didi Fabian, Elhassan Abdallah, Shehu U Abdullahi, Rula A Abdulqader, Sahadatou Adamou Boubacar, Dupe S Ademola-Popoola, Adedayo Adio, Armin R Afshar, Priyanka Aggarwal, Ada E Aghaji, Alia Ahmad, Marliyanti N R Akib, Lamis Al Harby, Mouroge H Al Ani, Aygun Alakbarova, Silvia Alarcón Portabella, Safaa A F Al-Badri, Ana Patricia A Alcasabas, Saad A Al-Dahmash, Amanda Alejos, Ernesto Alemany-Rubio, Amadou I Alfa Bio, Yvania Alfonso Carreras, Christiane Al-Haddad, Hamoud H Y Al-Hussaini, Amany M Ali, Donjeta B Alia, Mazin F Al-Jadiry, Usama Al-Jumaily, Hind M Alkatan, Charlotta All-Eriksson, Ali A R M Al-Mafrachi, Argentino A Almeida, Khalifa M Alsawidi, Athar A S M Al-Shaheen, Entissar H Al-Shammary, Primawita O Amiruddin, Romanzo Antonino, Nicholas J Astbury, Hatice T Atalay, La-Ongsri Atchaneeyasakul, Rose Atsiaya, Taweevat Attaseth, Than H Aung, Silvia Ayala, Baglan Baizakova, Julia Balaguer, Ruhengiz Balayeva, Walentyna Balwierz, Honorio Barranco, Covadonga Bascaran, Maja Beck Popovic, Raquel Benavides, Sarra Benmiloud, Nissrine Bennani Guebessi, Rokia C Berete, Jesse L Berry, Anirban Bhaduri, Sunil Bhat, Shelley J Biddulph, Eva M Biewald, Nadia Bobrova, Marianna Boehme, H C Boldt, Maria Teresa B C Bonanomi, Norbert Bornfeld, Gabrielle C Bouda, Hédi Bouguila, Amaria Boumedane, Rachel C Brennan, Bénédicte G Brichard, Jassada Buaboonnam, Patricia Calderón-Sotelo, Doris A Calle Jara, Jayne E Camuglia, Miriam R Cano, Michael Capra, Nathalie Cassoux, Guilherme Castela, Luis Castillo, Jaume Català-Mora, Guillermo L Chantada, Shabana Chaudhry, Sonal S Chaugule, Argudit Chauhan, Bhavna Chawla, Violeta S Chernodrinska, Faraja S Chiwanga, Tsengelmaa Chuluunbat, Krzysztof Cieslik, Ruellyn L Cockcroft, Codruta Comsa, Zelia M Correa, Maria G Correa Llano, Timothy W Corson, Kristin E Cowan-Lyn, Monika Csóka, Xuehao Cui, Isac V Da Gama, Wantanee Dangboon, Anirban Das, Sima Das, Jacquelyn M Davanzo, Alan Davidson, Patrick De Potter, Karina Q Delgado, Hakan Demirci, Laurence Desjardins, Rosdali Y Diaz Coronado, Helen Dimaras, Andrew J Dodgshun, Craig Donaldson, Carla R Donato Macedo, Monica D Dragomir, Yi Du, Magritha Du Bruyn, Kemala S Edison, I Wayan Eka Sutyawan, Asmaa El Kettani, Amal M Elbahi, James E Elder, Dina Elgalaly, Alaa M Elhaddad, Moawia M Ali Elhassan, Mahmoud M Elzembely, Vera A Essuman, Ted Grimbert A Evina, Zehra Fadoo, Adriana C Fandiño, Mohammad Faranoush, Oluyemi Fasina, Delia D P G Fernández, Ana Fernández-Teijeiro, Allen Foster, Shahar Frenkel, Ligia D Fu, Soad L Fuentes-Alabi, Brenda L Gallie, Moira Gandiwa, Juan L Garcia, David García Aldana, Pascale Y Gassant, Jennifer A Geel, Fariba Ghassemi, Ana V Girón, Zelalem Gizachew, Marco A Goenz, Aaron S Gold, Maya Goldberg-Lavid, Glen A Gole, Nir Gomel, Efren Gonzalez, Graciela Gonzalez Perez, Liudmira González-Rodríguez, Henry N Garcia Pacheco, Jaime Graells, Liz Green, Pernille A Gregersen, Nathalia D A K Grigorovski, Koffi M Guedenon, D Sanjeeva Gunasekera, Ahmet K Gündüz, Himika Gupta, Sanjiv Gupta, Theodora Hadjistilianou, Patrick Hamel, Syed A Hamid, Norhafizah Hamzah, Eric D Hansen, J William Harbour, M Elizabeth Hartnett, Murat Hasanreisoglu, Sadiq Hassan, Shadab Hassan, Stanislava Hederova, Jose Hernandez, Lorelay Marie Carcamo Hernandez, Laila Hessissen, Diriba F Hordofa, Laura C Huang, G B Hubbard, Marlies Hummlen, Kristina Husakova, Allawi N Hussein Al-Janabi, Russo Ida, Vesna R Ilic, Vivekaraj Jairaj, Irfan Jeeva, Helen Jenkinson, Xunda Ji, Dong Hyun Jo, Kenneth P Johnson, William J Johnson, Michael M Jones, Theophile B Amani Kabesha, Rolande L Kabore, Swathi Kaliki, Abubakar Kalinaki, Mehmet Kantar, Ling-Yuh Kao, Tamar Kardava, Rejin Kebudi, Tomas Kepak, Naama Keren-Froim, Zohora J Khan, Hussain A Khaqan, Phara Khauv, Wajiha J Kheir, Vikas Khetan, Alireza Khodabande, Zaza Khotenashvili, Jonathan W Kim, Jeong Hun Kim, Hayyam Kiratli, Tero T Kivelä, Artur Klett, Jess Elio Kosh Komba Palet, Dalia Krivaitiene, Mariana Kruger, Kittisak Kulvichit, Mayasari W Kuntorini, Alice Kyara, Eva S Lachmann, Carol P S Lam, Geoffrey C Lam, Scott A Larson, Slobodanka Latinovic, Kelly D Laurenti, Bao Han A Le, Karin Lecuona, Amy A Leverant, Cairui Li, Ben Limbu, Quah Boon Long, Juan P López, Robert M Lukamba, Livia Lumbroso, Sandra Luna-Fineman, Delfitri Lutfi, Lesia Lysytsia, George N Magrath, Amita Mahajan, Abdul Rahim Majeed, Erika Maka, Mayuri Makan, Emil K Makimbetov, Chatonda Manda, Nieves Martín Begue, Lauren Mason, John O Mason, Ibrahim O Matende, Miguel Materin, Clarissa C D S Mattosinho, Marchelo Matua, Ismail Mayet, Freddy B Mbumba, John D McKenzie, Aurora Medina-Sanson, Azim Mehrvar, Aemero A Mengesha, Vikas Menon, Gary John V D Mercado, Marilyn B Mets, Edoardo Midena, Divyansh K C Mishra, Furahini G Mndeme, Ahmed A Mohamedani, Mona T Mohammad, Annette C Moll, Margarita M Montero, Rosa A Morales, Claude Moreira, Prithvi Mruthyunjaya, Mchikirwa S Msina, Gerald Msukwa, Sangeeta S Mudaliar, Kangwa I Muma, Francis L Munier, Gabriela Murgoi, Timothy G Murray, Kareem O Musa, Asma Mushtaq, Hamzah Mustak, Okwen M Muyen, Gita Naidu, Akshay Gopinathan Nair, Larisa Naumenko, Paule Aïda Ndoye Roth, Yetty M Nency, Vladimir Neroev, Hang Ngo, Rosa M Nieves, Marina Nikitovic, Elizabeth D Nkanga, Henry Nkumbe, Murtuza Nuruddin, Mutale Nyaywa, Ghislaine Obono-Obiang, Ngozi C Oguego, Andrzej Olechowski, Scott C N Oliver, Peter Osei-Bonsu, Diego Ossandon, Manuel A Paez-Escamilla, Halimah Pagarra, Sally L Painter, Vivian Paintsil, Luisa Paiva, Bikramjit P Pal, Mahesh Shanmugam Palanivelu, Ruzanna Papyan, Raffaele Parrozzani, Manoj Parulekar, Claudia R Pascual Morales, Katherine E Paton, Katarzyna Pawinska-Wasikowska, Jacob Pe'er, Armando Peña, Sanja Peric, Chau T M Pham, Remezo Philbert, David A Plager, Pavel Pochop, Rodrigo A Polania, Vladimir G Polyakov, Manca T Pompe, Jonathan J Pons, Daphna Prat, Vireak Prom, Ignatius Purwanto, Ali O Qadir, Seema Qayyum, Jiang Qian, Ardizal Rahman, Salman Rahman, Jamalia Rahmat, Purnima Rajkarnikar, Rajesh Ramanjulu, Aparna Ramasubramanian, Marco A Ramirez-Ortiz, Léa Raobela, Riffat Rashid, M Ashwin Reddy, Ehud Reich, Lorna A Renner, David Reynders, Dahiru Ribadu, Mussagy M Riheia, Petra Ritter-Sovinz, Duangnate Rojanaporn, Livia Romero, Soma R Roy, Raya H Saab, Svetlana Saakyan, Ahmed H Sabhan, Mandeep S Sagoo, Azza M A Said, Rohit Saiju, Beatriz Salas, Sonsoles San Román Pacheco, Gissela L Sánchez, Phayvanh Sayalith, Trish A Scanlan, Amy C Schefler, Judy Schoeman, Ahad Sedaghat, Stefan Seregard, Rachna Seth, Ankoor S Shah, Shawkat A Shakoor, Manoj K Sharma, Sadik T Sherief, Nandan G Shetye, Carol L Shields, Sorath Noorani Siddiqui, Sidi Sidi Cheikh, Sónia Silva, Arun D Singh, Niharika Singh, Usha Singh, Penny Singha, Rita S Sitorus, Alison H Skalet, Hendrian D Soebagjo, Tetyana Sorochynska, Grace Ssali, Andrew W Stacey, Sandra E Staffieri, Erin D Stahl, Christina Stathopoulos, Branka Stirn Kranjc, David K Stones, Caron Strahlendorf, Maria Estela Coleoni Suarez, Sadia Sultana, Xiantao Sun, Meryl Sundy, Rosanne Superstein, Eddy Supriyadi, Supawan Surukrattanaskul, Shigenobu Suzuki, Karel Svojgr, Fatoumata Sylla, Gevorg Tamamyan, Deborah Tan, Alketa Tandili, Fanny F Tarrillo Leiva, Maryam Tashvighi, Bekim Tateshi, Edi S Tehuteru, Luiz F Teixeira, Kok Hoi Teh, Tuyisabe Theophile, Helen Toledano, Doan L Trang, Fousseyni Traoré, Sumalin Trichaiyaporn, Samuray Tuncer, Harba Tyau-Tyau, Ali B Umar, Emel Unal, Ogul E Uner, Steen F Urbak, Tatiana L Ushakova, Rustam H Usmanov, Sandra Valeina, Milo van Hoefen Wijsard, Adisai Varadisai, Liliana Vasquez, Leon O Vaughan, Nevyana V Veleva-Krasteva, Nishant Verma, Andi A Victor, Maris Viksnins, Edwin G Villacís Chafla, Vicktoria Vishnevskia-Dai, Tushar Vora, Antonio E Wachtel, Werner Wackernagel, Keith Waddell, Patricia D Wade, Amina H Wali, Yi-Zhuo Wang, Avery Weiss, Matthew W Wilson, Amelia D C Wime, Atchareeya Wiwatwongwana, Damrong Wiwatwongwana, Charlotte Wolley Dod, Phanthipha Wongwai, Daoman Xiang, Yishuang Xiao, Jason C Yam, Huasheng Yang, Jenny M Yanga, Muhammad A Yaqub, Vera A Yarovaya, Andrey A Yarovoy, Huijing Ye, Yacoub A Yousef, Putu Yuliawati, Arturo M Zapata López, Ekhtelbenina Zein, Chengyue Zhang, Yi Zhang, Junyang Zhao, Xiaoyu Zheng, Katsiaryna Zhilyaeva, Nida Zia, Othman A O Ziko, Marcia Zondervan, Richard Bowman
IMPORTANCE: Early diagnosis of retinoblastoma, the most common intraocular cancer, can save both a child's life and vision. However, anecdotal evidence suggests that many children across the world are diagnosed late. To our knowledge, the clinical presentation of retinoblastoma has never been assessed on a global scale. OBJECTIVES: To report the retinoblastoma stage at diagnosis in patients across the world during a single year, to investigate associations between clinical variables and national income level, and to investigate risk factors for advanced disease at diagnosis...
May 1, 2020: JAMA Oncology
#33
JOURNAL ARTICLE
Michael M Kheir, R Michael Meneghini
Antibiotic-impregnated intramedullary dowels historically have been advocated and are frequently used to facilitate periprosthetic knee infection eradication. They are used for focused delivery of antibiotics into the femoral and tibial intramedullary canals during 2-stage resection utilizing an antibiotic cement spacer. However, the literature is limited on the use and efficacy of antibiotic-eluding intramedullary dowels in periprosthetic joint infection. We reviewed the available literature and have found that the data at this point are equivocal with respect to whether antibiotic-impregnated cement intramedullary dowels augment the intra-articular antibiotic cement spacer in eradicating infection in total knee arthroplasty...
March 2020: Journal of Arthroplasty
#34
Adnan Majid, Gonzalo Labarca, Juan Pablo Uribe, Fayez Kheir, Cecilia Pacheco, Erik Folch, Michael A Jantz, Hiren J Mehta, Neal M Patel, Felix J F Herth, Sebastian Fernandez-Bussy
BACKGROUND: Spiration Valve System (SVS) is an alternative for patients with severe heterogeneous emphysema; however, data about efficacy from randomized controlled trials (RCT) are unclear. OBJECTIVES: To explore both efficacy and safety of SVS in patients with severe emphysema and hyperinflation. METHODS: We included PubMed, EMBASE, Coch-rane database. All searches were performed until August 2019. Only RCTs were included for analysis. Risk of bias was assessed using Cochrane risk of bias tool...
November 22, 2019: Respiration; International Review of Thoracic Diseases
#35
JOURNAL ARTICLE
Mirna Kheir Gouda, Michael Manhart, Gábor Balázsi
Evolutionary reversibility-the ability to regain a lost function-is an important problem both in evolutionary and synthetic biology, where repairing natural or synthetic systems broken by evolutionary processes may be valuable. Here, we use a synthetic positive-feedback (PF) gene circuit integrated into haploid Saccharomyces cerevisiae cells to test if the population can restore lost PF function. In previous evolution experiments, mutations in a gene eliminated the fitness costs of PF activation. Since PF activation also provides drug resistance, exposing such compromised or broken mutants to both drug and inducer should create selection pressure to regain drug resistance and possibly PF function...
November 21, 2019: Proceedings of the National Academy of Sciences of the United States of America
#36
JOURNAL ARTICLE
Payam Nahid, Sundari R Mase, Giovanni Battista Migliori, Giovanni Sotgiu, Graham H Bothamley, Jan L Brozek, Adithya Cattamanchi, J Peter Cegielski, Lisa Chen, Charles L Daley, Tracy L Dalton, Raquel Duarte, Federica Fregonese, C Robert Horsburgh, Faiz Ahmad Khan, Fayez Kheir, Zhiyi Lan, Alfred Lardizabal, Michael Lauzardo, Joan M Mangan, Suzanne M Marks, Lindsay McKenna, Dick Menzies, Carole D Mitnick, Diana M Nilsen, Farah Parvez, Charles A Peloquin, Ann Raftery, H Simon Schaaf, Neha S Shah, Jeffrey R Starke, John W Wilson, Jonathan M Wortham, Terence Chorba, Barbara Seaworth
Background: The American Thoracic Society, U.S. Centers for Disease Control and Prevention, European Respiratory Society, and Infectious Diseases Society of America jointly sponsored this new practice guideline on the treatment of drug-resistant tuberculosis (DR-TB). The document includes recommendations on the treatment of multidrug-resistant TB (MDR-TB) as well as isoniazid-resistant but rifampin-susceptible TB. Methods: Published systematic reviews, meta-analyses, and a new individual patient data meta-analysis from 12,030 patients, in 50 studies, across 25 countries with confirmed pulmonary rifampin-resistant TB were used for this guideline...
November 15, 2019: American Journal of Respiratory and Critical Care Medicine
#37
JOURNAL ARTICLE
Gonzalo Labarca, Melibea Sierra-Ruiz, Fayez Kheir, Erik Folch, Adnan Majid, Hiren J Mehta, Michael A Jantz, Sebastian Fernandez-Bussy
Rationale: Endobronchial ultrasound with transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive method used to diagnose suspected mediastinal lymph nodes or masses. However, the accuracy of the diagnosis in patients with suspected lymphoma is unclear. Objectives: To evaluate the diagnostic yield of EBUS-TBNA in patients with suspected lymphoma. Methods: A literature search including EMBASE, MEDLINE, Cochrane Library, and Google Scholar was performed by two reviewers. Included articles were evaluated using the QUADAS-2 tool and meta-analysis with a binary method model to compare the sensitivity, specificity, and summary receiver operating characteristic curve in patients with suspected lymphoma...
November 2019: Annals of the American Thoracic Society
#38
JOURNAL ARTICLE
Timothy L Tan, Karan Goswami, Michael M Kheir, Chi Xu, Qiaojie Wang, Javad Parvizi
BACKGROUND: Patients with periprosthetic joint infection (PJI) undergoing 2-stage exchange arthroplasty may undergo an interim spacer exchange for a variety of reasons including mechanical failure of spacer or persistence of infection. The objective of this study is to understand the risk factors and outcomes of patients who undergo spacer exchange during the course of a planned 2-stage exchange arthroplasty. METHODS: Our institutional database was used to identify 533 patients who underwent a 2-stage exchange arthroplasty for PJI, including 90 patients with a spacer exchange, from 2000 to 2017...
September 2019: Journal of Arthroplasty
#39
JOURNAL ARTICLE
Fayez Kheir, Mengmeng Zhao, Michael J Strong, Yi Yu, Asuka Nanbo, Erik K Flemington, Gilbert F Morris, Krzysztof Reiss, Li Li, Zhen Lin
Previous investigations proposed a link between the Epstein-Barr virus (EBV) and lung cancer (LC), but the results are highly controversial largely due to the insufficient sample size and the inherent limitation of the traditional viral screening methods such as PCR. Unlike PCR, current next-generation sequencing (NGS) utilizes an unbiased method for the global assessment of all exogenous agents within a cancer sample with high sensitivity and specificity. In our current study, we aim to resolve this long-standing controversy by utilizing our unbiased NGS-based informatics approaches in conjunction with traditional molecular methods to investigate the role of EBV in a total of 1127 LC...
May 31, 2019: Cancers
#40
JOURNAL ARTICLE
Gonzalo Labarca, Juan Pablo Uribe, Cecilia Pacheco, Erik Folch, Fayez Kheir, Adnan Majid, Michael A Jantz, Hiren J Mehta, Neal Patel, Felix J F Herth, Sebastian Fernandez-Bussy
BACKGROUND: Endoscopic lung volume reduction using Zephyr® valves has been recently adopted as a treatment option for patients with severe emphysema without collateral ventilation (CV). OBJECTIVES: To assess the efficacy and safety of Zephyr valves in such a population. METHODS: Studies were identified from MEDLINE and EMBASE databases. All searches were current until June 2018. We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) evaluating the efficacy and safety of Zephyr...
2019: Respiration; International Review of Thoracic Diseases
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