keyword
https://read.qxmd.com/read/38103805/clinical-and-biomechanical-evaluation-of-midlevel-constrained-and-posterior-stabilized-polyethylene-inserts-in-primary-total-knee-arthroplasty-an-analysis-of-12-674-cases
#1
JOURNAL ARTICLE
Cynthia A Kahlenberg, Michael M Kheir, Isaiah Selkridge, Fernando J Quevedo Gonzalez, Yu-Fen Chiu, Timothy M Wright, Brian P Chalmers, Peter K Sculco
INTRODUCTION: Mid-level constraint polyethylene designs provide additional stability in total knee arthroplasty (TKA). The purposes of this study were to: 1) compare the survivorship and reason for revision between mid-level inserts and posterior-stabilized (PS) used in primary TKA, and 2) evaluate the biomechanical constraint characteristics of mid-level inserts. METHODS: We reviewed all cases of primary TKA performed at our institution from 2016 to 2019 using either PS or mid-level constrained inserts from one of six manufacturers...
December 14, 2023: Journal of Arthroplasty
https://read.qxmd.com/read/37875044/the-rapid-rebound-of-invasive-meningococcal-disease-in-france-at-the-end-of-2022
#2
JOURNAL ARTICLE
Samy Taha, Eva Hong, Mélanie Denizon, Michael Falguières, Aude Terrade, Ala-Eddine Deghmane, Muhamed-Kheir Taha
BACKGROUND: Invasive meningococcal disease (IMD) cases declined upon the implementation of non-pharmaceutical measures to control the COVID-19 pandemic. A rebound in IMD cases was feared upon easing these measures. METHODS: We conducted a retrospective descriptive study using the French National Reference Center Database for meningococci between 2015 and 2022. We scored serogroups, sex, age groups, and clonal complexes of the corresponding isolates. FINDINGS: Our data clearly show a decline in the number of IMD cases for all serogroups and age groups until 2021...
December 2023: Journal of Infection and Public Health
https://read.qxmd.com/read/37190236/epithelial-to-mesenchymal-transition-related-markers-in-prostate-cancer-from-bench-to-bedside
#3
REVIEW
Samantha Gogola, Michael Rejzer, Hisham F Bahmad, Wassim Abou-Kheir, Yumna Omarzai, Robert Poppiti
Prostate cancer (PCa) is the second most frequent type of cancer in men worldwide, with 288,300 new cases and 34,700 deaths estimated in the United States in 2023. Treatment options for early-stage disease include external beam radiation therapy, brachytherapy, radical prostatectomy, active surveillance, or a combination of these. In advanced cases, androgen-deprivation therapy (ADT) is considered the first-line therapy; however, PCa in most patients eventually progresses to castration-resistant prostate cancer (CRPC) despite ADT...
April 14, 2023: Cancers
https://read.qxmd.com/read/37093796/comparison-of-new-and-emerging-sars-cov-2-variant-transmissibility-through-active-contact-testing-a-comparative-cross-sectional-household-seroprevalence-study
#4
JOURNAL ARTICLE
Katherine M Gaskell, Natalie El Kheir, Mariyam Mirfendesky, Tommy Rampling, Michael Marks, Catherine F Houlihan, Norbert Lemonge, Hannah Bristowe, Suhail Aslam, Demetra Kyprianou, Eleni Nastouli, David Goldblatt, Katherine Fielding, David A J Moore
Historically SARS-CoV-2 secondary attack rates (SAR) have been based on PCR positivity on screening symptomatic contacts; this misses transmission events and identifies only symptomatic contacts who are PCR positive at the time of sampling. We used serology to detect the relative transmissibility of Alpha Variant of Concern (VOC) to non-VOC SARS-CoV-2 to calculate household secondary attack rates. We identified index patients diagnosed with Alpha and non-VOC SARS-CoV-2 across two London Hospitals between November 2020 and January 2021 during a prolonged and well adhered national lockdown...
2023: PloS One
https://read.qxmd.com/read/36693514/diagnostic-utility-and-thresholds-for-commonly-obtained-serum-and-synovial-markers-prior-to-reimplantation-in-periprosthetic-joint-infection
#5
JOURNAL ARTICLE
Abhijit Seetharam, Julian E Dilley, R Michael Meneghini, Michael M Kheir
BACKGROUND: Accurate diagnosis of persistent periprosthetic joint infection (PJI) during 2-stage exchange remains a challenge. This study evaluated the diagnostic performance and thresholds of several commonly obtained serum and synovial markers to better guide reimplantation timing. METHODS: This was a retrospective review of 249 patients who underwent 2-stage exchange with antibiotic spacers for PJI. Serum and synovial markers analyzed included white blood cell (WBC) count, polymorphonuclear percentage (PMN%), neutrophil-to-lymphocyte ratio (NLR), and absolute neutrophil count (ANC)...
January 21, 2023: Journal of Arthroplasty
https://read.qxmd.com/read/36283515/the-influence-of-dorr-type-and-femoral-fixation-on-outcomes-following-total-hip-arthroplasty-for-acute-femoral-neck-fractures-a-multicenter-study
#6
JOURNAL ARTICLE
Michael M Kheir, Julian E Dilley, Jacob Speybroeck, Emile-Victor Kuyl, George Ochenjele, Alexander S McLawhorn, R Michael Meneghini
INTRODUCTION: The American Academy of Orthopaedic Surgeons guidelines report moderate evidence for cementing femoral stems for hip fractures, mainly derived from hemiarthroplasty literature. This is the first large, non-registry study examining the influence of femoral fixation, implant type, patient characteristics, and radiographic factors on outcomes after total hip arthroplasty (THA) for acute femoral neck fractures. METHODS: A multicenter retrospective study was performed of 709 THA cases (199 cemented, 510 cementless) for femoral neck fractures from 2006 to 2020 at three large academic institutions...
October 22, 2022: Journal of Arthroplasty
https://read.qxmd.com/read/35843381/synovial-fluid-absolute-neutrophil-count-and-neutrophil-to-lymphocyte-ratio-are-not-superior-to-polymorphonuclear-percentage-in-detecting-periprosthetic-joint-infection
#7
JOURNAL ARTICLE
Julian E Dilley, Abhijit Seetharam, R Michael Meneghini, Michael M Kheir
BACKGROUND: Serum and synovial biomarkers are currently used to diagnose periprosthetic joint infection (PJI). Serum neutrophil-to-lymphocyte ratio (NLR) has shown promise as an inexpensive test in diagnosing infection, but there are no reports of synovial NLR or absolute neutrophil count (ANC) for diagnosing chronic PJI. The purpose of this study was to investigate the diagnostic potential of both markers. METHODS: A retrospective review of 730 patients who underwent total joint arthroplasty and subsequent aspiration was conducted...
July 16, 2022: Journal of Arthroplasty
https://read.qxmd.com/read/35726876/synovial-fluid-and-serum-neutrophil-to-lymphocyte-ratio-novel-biomarkers-for-the-diagnosis-and-prognosis-of-native-septic-arthritis-in-adults
#8
JOURNAL ARTICLE
Nathan H Varady, Pierre-Emmanuel Schwab, Michael M Kheir, Julian E Dilley, Hany Bedair, Antonia F Chen
BACKGROUND: Septic arthritis (SA) is a musculoskeletal emergency for which prompt diagnosis and treatment are critical. However, traditional diagnostic criteria of a synovial fluid (SF) white blood-cell count (WBC) of >50,000 cells/mm 3 or >90% polymorphonuclear leukocytes (%PMN) are not particularly sensitive or specific for the diagnosis of SA. Furthermore, prognostic markers are lacking. The purposes of this study were to assess the discriminative ability of the SF neutrophil-to-lymphocyte ratio (NLR) in the diagnosis of SA and of the serum NLR in the prognosis of SA...
September 7, 2022: Journal of Bone and Joint Surgery. American Volume
https://read.qxmd.com/read/35617288/long-term-impact-of-invasive-meningococcal-disease-in-children-seine-study-protocol
#9
JOURNAL ARTICLE
Alexiane Baloche, Camille Jung, Michael Levy, Annie Elbez-Rubinstein, Stéphane Béchet, Ines Layouni, Geneviève Monguillot, Muhamed Kheir Taha, Robert Cohen, Corinne Levy
INTRODUCTION: Invasive meningococcal disease (IMD) is still an important cause of mortality in children and survivors can have significant long-term disabling sequelae. There are few prospective studies looking at the long term neuropsychological and developmental consequences of IMD in surviving children, and the rate of sequelae may be underestimated. The SEINE study aims to have a more reliable estimate of the real rate of sequelae by assessing the long-term physical, neuropsychological, learning disorders and sensory sequelae of IMD in children and adolescents and by assessing the post-traumatic stress in parents...
2022: PloS One
https://read.qxmd.com/read/35499855/transbronchial-lung-cryobiopsy-in-patients-with-interstitial-lung-disease-a-systematic-review
#10
JOURNAL ARTICLE
Fayez Kheir, Juan Pablo Uribe Becerra, Brittany Bissell, Marya Ghazipura, Derrick Herman, Stephanie M Hon, Tanzib Hossain, Yet H Khor, Shandra L Knight, Michael Kreuter, Madalina Macrea, Manoj J Mammen, Fernando J Martinez, Venerino Poletti, Lauren Troy, Ganesh Raghu, Kevin C Wilson
Rationale: In 2018, a systematic review evaluating transbronchial lung cryobiopsy (TBLC) in patients with interstitial lung disease (ILD) was performed to inform American Thoracic Society, European Respiratory Society, Japanese Respiratory Society, and Asociación Latinoamericana del Tórax clinical practice guidelines on the diagnosis of idiopathic pulmonary fibrosis. Objectives: To perform a new systematic review to inform updated guidelines. Methods: Medline, Excerpta Medica Database, and the Cochrane Central Register of Controlled Trials (CCTR) were searched through June 2020...
July 2022: Annals of the American Thoracic Society
https://read.qxmd.com/read/35486080/antacid-medication-and-antireflux-surgery-in-patients-with-idiopathic-pulmonary-fibrosis-a-systematic-review-and-meta-analysis
#11
JOURNAL ARTICLE
Yet H Khor, Brittany Bissell, Marya Ghazipura, Derrick Herman, Stephanie M Hon, Tanzib Hossain, Fayez Kheir, Shandra L Knight, Michael Kreuter, Madalina Macrea, Manoj J Mammen, Maria Molina-Molina, Moises Selman, Marlies Wijsenbeek, Ganesh Raghu, Kevin C Wilson
Rationale: Idiopathic pulmonary fibrosis (IPF) is a fibrosing interstitial pneumonia with impaired survival. Previous guidelines recommend antacid medication to improve respiratory outcomes in patients with IPF. Objectives: This systematic review was undertaken during the development of an American Thoracic Society, European Respiratory Society, Japanese Respiratory Society, and Asociación Latinoamericana del Tórax guideline. The clinical question was, "Should patients with IPF who have documented abnormal gastroesophageal reflux (GER) with or without symptoms of GER disease 1 ) be treated with antacid medication or 2 ) undergo antireflux surgery to improve respiratory outcomes?" Methods: Medline, Embase, the Cochrane Central Register of Controlled Trials, and the gray literature were searched through June 30, 2020...
May 2022: Annals of the American Thoracic Society
https://read.qxmd.com/read/35486072/idiopathic-pulmonary-fibrosis-an-update-and-progressive-pulmonary-fibrosis-in-adults-an-official-ats-ers-jrs-alat-clinical-practice-guideline
#12
JOURNAL ARTICLE
Ganesh Raghu, Martine Remy-Jardin, Luca Richeldi, Carey C Thomson, Yoshikazu Inoue, Takeshi Johkoh, Michael Kreuter, David A Lynch, Toby M Maher, Fernando J Martinez, Maria Molina-Molina, Jeffrey L Myers, Andrew G Nicholson, Christopher J Ryerson, Mary E Strek, Lauren K Troy, Marlies Wijsenbeek, Manoj J Mammen, Tanzib Hossain, Brittany D Bissell, Derrick D Herman, Stephanie M Hon, Fayez Kheir, Yet H Khor, Madalina Macrea, Katerina M Antoniou, Demosthenes Bouros, Ivette Buendia-Roldan, Fabian Caro, Bruno Crestani, Lawrence Ho, Julie Morisset, Amy L Olson, Anna Podolanczuk, Venerino Poletti, Moisés Selman, Thomas Ewing, Stephen Jones, Shandra L Knight, Marya Ghazipura, Kevin C Wilson
Background: This American Thoracic Society, European Respiratory Society, Japanese Respiratory Society, and Asociación Latinoamericana de Tórax guideline updates prior idiopathic pulmonary fibrosis (IPF) guidelines and addresses the progression of pulmonary fibrosis in patients with interstitial lung diseases (ILDs) other than IPF. Methods: A committee was composed of multidisciplinary experts in ILD, methodologists, and patient representatives. 1 ) Update of IPF: Radiological and histopathological criteria for IPF were updated by consensus...
May 1, 2022: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/35439226/corr-insights%C3%A2-for-patients-with-acute-pji-treated-with-debridement-antibiotics-and-implant-retention-what-factors-are-associated-with-systemic-sepsis-and-recurrent-or-persistent-infection-in-septic-patients
#13
COMMENT
https://read.qxmd.com/read/35368851/diagnosis-of-prostate-adenocarcinoma-on-routine-pathology-after-a-primary-total-hip-arthroplasty
#14
Michael M Kheir, Thomas W Bauer, Geoffrey H Westrich
We present a 67-year-old male patient who presented with insidious worsening of right hip pain over a 6-month period with clinical and radiographic evidence of severe osteoarthritis. The patient underwent a primary total hip arthroplasty where the femoral head specimen was sent to pathology as a routine specimen. Pathology results demonstrated metastatic adenocarcinoma of prostate origin. The present case emphasizes the importance of routine pathologic examination of femoral head specimens retrieved during total hip arthroplasty, particularly since this was a clinically unsuspected finding...
June 2022: Arthroplasty Today
https://read.qxmd.com/read/35077819/reduced-infection-rate-after-aseptic-revision-total-knee-arthroplasty-with-extended-oral-antibiotic-protocol
#15
JOURNAL ARTICLE
Matthieu Zingg, Michael M Kheir, Mary Ziemba-Davis, R Michael Meneghini
BACKGROUND: The optimal postoperative antibiotic duration has not been determined for aseptic revision total knee arthroplasty (R-TKA) where the risk of periprosthetic joint infection (PJI) is 3%-7.5%. This study compared PJI rates in aseptic R-TKA performed with extended oral antibiotic prophylaxis (EOAP) to published rates. METHODS: Aseptic R-TKAs consecutively performed between 2013 and 2017 at a tertiary care referral center in the American Midwest were retrospectively reviewed...
May 2022: Journal of Arthroplasty
https://read.qxmd.com/read/34651133/safety-of-prolonged-inhalation-of-hydrogen-gas-in-air-in-healthy-adults
#16
JOURNAL ARTICLE
Alexis R Cole, Francesca Sperotto, James A DiNardo, Stephanie Carlisle, Michael J Rivkin, Lynn A Sleeper, John N Kheir
Ischemia-reperfusion injury is common in critically ill patients, and directed therapies are lacking. Inhaled hydrogen gas diminishes ischemia-reperfusion injury in models of shock, stroke, and cardiac arrest. The purpose of this study was to investigate the safety of inhaled hydrogen gas at doses required for a clinical efficacy study. DESIGN: Prospective, single-arm study. SETTING: Tertiary care hospital. PATIENTS/SUBJECTS: Eight healthy adult participants...
October 2021: Critical care explorations
https://read.qxmd.com/read/34595847/unique-serum-immune-phenotypes-stratify-oklahoma-native-american-rheumatic-disease-patients
#17
JOURNAL ARTICLE
Samantha Slight-Webb, Carla J Guthridge, Joseph Kheir, Hua Chen, Ly Tran, Tim Gross, Virginia Roberts, Sohail Khan, Michael Peercy, Bobby Saunkeah, Joel M Guthridge, Judith A James
OBJECTIVE: Native American (NA) populations have higher rates of rheumatic disease and present with overlapping disease symptoms and nontraditional serological features, thus presenting an urgent need for better biomarkers in NA diagnostics. This study utilized a machine-learning approach to identify immune signatures that more effectively stratify NA rheumatic disease patients. METHODS: Adult NA patients with autoantibody-positive (AAB+) rheumatoid arthritis (RA) (n=28), autoantibody negative (AAB-) RA (n=18), systemic autoimmune rheumatic disease (n=28), arthralgia/osteoarthritis (n=28), polyarthritis/undifferentiated connective tissue disease (n=28), and controls (n=28) provided serum samples for cytokine, chemokine, and autoantibody assessment...
October 1, 2021: Arthritis Care & Research
https://read.qxmd.com/read/34389452/modeling-severe-functional-impairment-or-death-following-ecpr-in-pediatric-cardiac-patients-planning-for-an-interventional-trial
#18
JOURNAL ARTICLE
Francesca Sperotto, Kwannapas Saengsin, Amy Danehy, Manasee Godsay, Diana L Geisser, Michael Rivkin, Angela Amigoni, Ravi R Thiagarajan, John N Kheir
AIM: We aimed to characterize extracorporeal CPR (ECPR) outcomes in our center and to model prediction of severe functional impairment or death at discharge. METHODS: All ECPR events between 2011 and 2019 were reviewed. The primary outcome measure was severe functional impairment or death at discharge (Functional Status Score [FSS] ≥ 16). Organ dysfunction was graded using the Pediatric Logistic Organ Dysfunction Score-2, neuroimaging using the modified Alberta Stroke Program Early Computed Tomography Score...
October 2021: Resuscitation
https://read.qxmd.com/read/34330228/haemophilus-influenzae-type-b-hib-seroprevalence-in-france-impact-of-vaccination-schedules
#19
JOURNAL ARTICLE
Eva Hong, Aude Terrade, Mélanie Denizon, Myriam Aouiti-Trabelsi, Michaël Falguières, Muhamed-Kheir Taha, Ala-Eddine Deghmane
BACKGROUND: Haemophilus influenzae serotype b (Hib) conjugate vaccine was introduced in France in 1992 as a 3 + 1 scheme at 2, 3, and 4 months (primary vaccination) with a booster at the age of 16-18 months. The vaccination was simplified in 2013 to a 2 + 1 scheme at 2 and 4 months (primary immunization) and a booster at the age of 11 months. The coverage was 95.4% in France at 24 months in 2017. During the period 2017-2019 the number of Hib invasive infections increased with several cases of vaccine failure...
July 30, 2021: BMC Infectious Diseases
https://read.qxmd.com/read/34077697/use-of-a-genomic-classifier-in-patients-with-interstitial-lung-disease-a-systematic-review-and-meta-analysis
#20
JOURNAL ARTICLE
Fayez Kheir, Juan Pablo Uribe Becerra, Brittany Bissell, Marya Ghazipura, Derrick Herman, Stephanie M Hon, Tanzib Hossain, Yet H Khor, Shandra L Knight, Michael Kreuter, Madalina Macrea, Manoj J Mammen, Fernando J Martinez, Venerino Poletti, Lauren Troy, Ganesh Raghu, Kevin C Wilson
Background: Usual interstitial pneumonia (UIP) is the histopathologic hallmark of idiopathic pulmonary fibrosis (IPF), the prototypical interstitial lung disease (ILD). Diagnosis of IPF requires that a typical UIP pattern be identified by using high-resolution chest computed tomography or lung sampling. A genomic classifier for UIP has been developed to predict histopathologic UIP by using lung samples obtained through bronchoscopy. Objective: To perform a systematic review to evaluate genomic classifier testing in the detection of histopathologic UIP to inform new American Thoracic Society, European Respiratory Society, Japanese Respiratory Society, and Asociación Latinoamericana del Tórax guidelines...
May 2022: Annals of the American Thoracic Society
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