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Foxo3a SirT3

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https://www.readbyqxmd.com/read/30091830/sirtuin3-protects-aged-human-mesenchymal-stem-cells-against-oxidative-stress-and-enhances-efficacy-of-cell-therapy-for-ischaemic-heart-diseases
#1
Dong-Yang Zhang, Chun-Feng Zhang, Bi-Cheng Fu, Lu Sun, Xue-Qing Wang, Wei Chen, Wei Liu, Kai-Yu Liu, Guo-Qing Du, Chong-Yi Ma, Shu-Lin Jiang, Ren-Ke Li, Hai Tian
Sirtuin3 (SIRT3) is associated with oxidative stress and lifespan. However, the possible mechanisms underlying its influence are unknown. We hypothesized that SIRT3 increases the antioxidant capacity of aged cells and improves the efficacy of human mesenchymal stem cell (hMSC) therapy for ischaemic heart diseases in aged patients. In vitro, the antioxidant capacity of old hMSCs (O-hMSCs) was increased after SIRT3 overexpression using a gene transfection technique, while the antioxidant capacity of young hMSCs (Y-hMSCs) was decreased by SIRT3 silencing...
August 9, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29915018/suppression-of-endothelial-to-mesenchymal-transition-by-sirt-sirtuin-3-alleviated-the-development-of-hypertensive-renal-injury
#2
Jing-Rong Lin, Yan-Jun Zheng, Ze-Bei Zhang, Wei-Li Shen, Xiao-Dong Li, Tong Wei, Cheng-Chao Ruan, Xiao-Hui Chen, Ding-Liang Zhu, Ping-Jin Gao
Endothelial-to-mesenchymal transition (EndoMT) has recently emerged as a potentially important contributor in promoting fibrosis in chronic kidney disease. However, little is known about the role and molecular basis of its involvement in hypertensive renal injury. Here, we aim to determine the role of SIRT (sirtuin) 3 on EndoMT in hypertensive renal injury and to explore its underlying mechanisms. We found that SIRT3 expression was significantly reduced in Ang II (angiotensin II)-induced hypertensive model, accompanied with induction of EndoMT and increased reactive oxygen species and renal fibrosis...
August 2018: Hypertension
https://www.readbyqxmd.com/read/29898623/depletion-of-sirt3-leads-to-the-impairment-of-adipogenic-differentiation-and-insulin-resistance-via-interfering-mitochondrial-function-of-adipose-derived-human-mesenchymal-stem-cells
#3
Yu-Ting Wu, Kun-Ting Chi, Yueh-Wen Lan, Jui-Chi Chan, Yi-Shing Ma, Yau-Huei Wei
Upregulation of mitochondrial function and oxidative metabolism is a hallmark in the differentiation of stem cells. However, the mechanism underlying the metabolic reprogramming and upregulation of mitochondrial function during the differentiation of human mesenchymal stem cells (hMSCs) is largely unclear. Sirt3 has emerged as a sensor in regulating mitochondrial function and antioxidant defence system in cellular response to energy demand or environmental stimuli, but its roles in stem cell differentiation have not been fully understood...
July 23, 2018: Free Radical Research
https://www.readbyqxmd.com/read/29421536/sirt3-inhibits-prostate-cancer-metastasis-through-regulation-of-foxo3a-by-suppressing-wnt-%C3%AE-catenin-pathway
#4
Rong Li, Yizhou Quan, Weiliang Xia
SIRT3, a mitochondrial NAD+ -dependent deacetylase, has been reported to restrain prostate cancer growth both in vitro and in vivo, however, its role in metastatic prostate cancer has not been revealed. In this study, we reported that SIRT3 inhibited the epithelial-mesenchymal transition (EMT) and migration of prostatic cancer cells in vitro and their metastasis in vivo. Consistently, based on analyses of tissue microarray and microarray datasets, lower SIRT3 expression level was correlated with higher prostate cancer Gleason scores, and SIRT3 expression were significantly decreased in metastatic tissues compared with prostate tumor tissues...
March 15, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29411439/insulin-signaling-pathway-protects-neuronal-cell-lines-by-sirt3-mediated-irs2-activation
#5
Neha Mishra, Sonam Lata, Priyanka Deshmukh, Kajal Kamat, Avadhesha Surolia, Tanushree Banerjee
Cellular stress like ER and oxidative stress are the principle causative agents of various proteinopathies. Multifunctional protein PARK7/DJ-1 provides protection against cellular stress. Recently, insulin/IGF also has emerged as a neuro-protective molecule. However, it is not known whether DJ-1 and insulin/IGF complement each other for cellular protection in response to stress. In this study, we show for the first time, that in human and mouse neuronal cell lines, down regulation of DJ-1 for 48 h leads to compensatory upregulation of insulin/IGF signaling (IIS) pathway genes, namely, insulin receptor, insulin receptor substrate, and Akt under normal physiological conditions as well as in cellular stress conditions...
May 2018: BioFactors
https://www.readbyqxmd.com/read/29198881/role-of-arsenic-exposure-in-adipose-tissue-dysfunction-and-its-possible-implication-in-diabetes-pathophysiology
#6
REVIEW
Kaviyarasi Renu, Harishkumar Madhyastha, Radha Madhyastha, Masugi Maruyama, Sankarganesh Arunachlam, Abilash V G
Exposure to arsenic in drinking water can stimulate a diverse number of diseases that originate from impaired lipid metabolism in adipose and glucose metabolism, leading to insulin resistance. Arsenic inhibits differentiation of adipocyte and mediates insulin resistance with diminutive information on arsenicosis on lipid storage and lipolysis. This review focused on different mechanisms and pathways involved in adipogenesis and lipolysis in adipose tissue during arsenic-induced diabetes. Though arsenic is known to cause type2 diabetes through different mechanisms, the role of adipose tissue in causing type2 diabetes is still unclear...
March 1, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/28912098/melatonin-mediated-upregulation-of-sirt3-attenuates-sodium-fluoride-induced-hepatotoxicity-by-activating-the-mt1-pi3k-akt-pgc-1%C3%AE-signaling-pathway
#7
Chao Song, Jiamin Zhao, Beibei Fu, Dan Li, Tingchao Mao, Wei Peng, Haibo Wu, Yong Zhang
Mitochondrial reactive oxygen species (ROS) production has been implicated in the pathogenesis of fluoride toxicity in liver. Melatonin, an indolamine synthesized in the pineal gland, was previously shown to protect against sodium fluoride (NaF)-induced hepatotoxicity. This study investigated the protective effects of melatonin pretreatment on NaF-induced hepatotoxicity and elucidates the potential mechanism of melatonin-mediated protection. Reducing mitochondrial ROS by melatonin substantially attenuated NaF-induced NADPH oxidase 4 (Nox4) upregulation and cytotoxicity in L-02 cells...
November 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28526626/longevity-and-healthy-ageing-genes-foxo3a-and-sirt3-serum-protein-marker-and-new-road-map-to-burst-oxidative-stress-by-withania-somnifera
#8
Rashmita Pradhan, Rahul Kumar, Shashank Shekhar, Nitish Rai, Akash Ambashtha, Joyita Banerjee, Mona Pathak, S N Dwivedi, Sharmistha Dey, Aparajit B Dey
BACKGROUND: Ageing process is characterized by a decline in function; different age related diseases and excessive age associated mortality. There has always been a quest for easily accessible biomarkers to monitor and identify the development of age-associated stress for providing new anti-ageing strategies. Forkhead box protein O3A (FOXO3A) and Sirtuin3 (SIRT3) are such potential markers which plays important role in a wide variety of cellular mechanisms and has been proposed to be an ideal candidate to study longevity and are potential candidate for healthy ageing by oxidative burst...
September 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28506746/the-nad-dependent-deacetylase-bifidobacterium-longum-sir2-in-response-to-oxidative-stress-by-deacetylating-sigh-%C3%AF-h-and-foxo3a-in-bifidobacterium-longum-and-hek293t-cell-respectively
#9
Qing Guo, Shiyu Li, Yajie Xie, Qian Zhang, Mengge Liu, Zhenrui Xu, Hanxiao Sun, Yan Yang
Silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. The mammalian sirtuin family SIRT1, SIRT2, SIRT3 and SIRT6 can regulate oxidative stress. The probiotics (Bifidobacterium longum(B.longum) and Lactobacillus acidophilus(L. acidophilus)) have Sir2 gene family and have antioxidant activity in human body. it remains unknown whether probiotics Sir2 has a direct role in regulating oxidative stress. To this end, we knockout BL-sir2(sir2 B. longum) and LA-sir2(sir2 L...
July 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28386112/sodium-fluoride-induces-nephrotoxicity-via-oxidative-stress-regulated-mitochondrial-sirt3-signaling-pathway
#10
Chao Song, Beibei Fu, Jingcheng Zhang, Jiamin Zhao, Mengke Yuan, Wei Peng, Yong Zhang, Haibo Wu
Accumulation of mitochondrial reactive oxygen species (mROS) has been implicated in the pathogenesis of fluorosis. As the main mitochondrial deacetylase, SIRT3 is closely associated with oxidative stress. To investigate the role of SIRT3 in response to sodium fluoride (NaF)-induced nephrotoxicity. Our results showed that NaF treatment impaired mitochondrial ultrastructure, decreased cell viability and increased apoptosis in TCMK-1 cells. Oxidative stress, detected by mROS and 8-Hydroxy-2'-deoxyguanosine (8-OHdG) were higher in NaF-treated cells, accompanied by decreased level of reduced glutathione (GSH)...
April 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28286268/resveratrol-rescues-cadmium-induced-mitochondrial-injury-by-enhancing-transcriptional-regulation-of-pgc-1%C3%AE-and-sod2-via-the-sirt3-foxo3a-pathway-in-tcmk-1-cells
#11
Beibei Fu, Jiamin Zhao, Wei Peng, Haibo Wu, Yong Zhang
Resveratrol has been reported to ameliorate Cd-induced nephrotoxicity. However, the beneficial effects of resveratrol on Cd-induced nephrotoxicity and the underlying mechanisms of this protection remain unclear. Here, we showed that mouse renal tubular epithelial (TCMK-1) cells exposed to Cd experienced significantly increased mitochondrial reactive oxygen species (mROS) production, as well as decreased mitochondrial biogenesis and function. Cd exposure dramatically decreased Sirt3 protein expression and activity and promoted the acetylation of forkhead box O3 (FoxO3a)...
April 22, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28202079/a-novel-cytoprotective-peptide-protects-mesenchymal-stem-cells-against-mitochondrial-dysfunction-and-apoptosis-induced-by-starvation-via-nrf2-sirt3-foxo3a-pathway
#12
Shuo Wang, Chao Zhang, Sidikejiang Niyazi, Long Zheng, Jiawei Li, Weitao Zhang, Ming Xu, Ruiming Rong, Cheng Yang, Tongyu Zhu
BACKGROUND: Mesenchymal stem cell (MSC) has been widely explored in the past decade as a cell-based treatment for various diseases. However, poor survival of adaptively transferred MSCs limits their clinical therapeutic potentials, which is largely ascribed to the nutrient starvation. In this study, we determined whether a novel kidney protective peptide CHBP could protect MSCs against starvation and invested the underlying mechanisms. METHODS: MSCs were subjected to serum deprivation and CHBP of graded concentrations was administered...
February 15, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27794418/sirt3-deficiency-exacerbates-diabetic-cardiac-dysfunction-role-of-foxo3a-parkin-mediated-mitophagy
#13
REVIEW
Wenjun Yu, Beilei Gao, Na Li, Jiaxing Wang, Cuiting Qiu, Guoyong Zhang, Min Liu, Rongqing Zhang, Congye Li, Gang Ji, Yingmei Zhang
Diabetic cardiomyopathy (DCM) is often associated with suppressed cardiac autophagy, mitochondrial structural and functional impairment. Sirtuin-3 (Sirt3) has been reported to play a crucial role in mitochondrial homeostasis and confers a protective role against the onset and development of DCM although the precise mechanism(s) remains elusive. Here we hypothesized that Sirt3 exerts cardioprotection against DCM by activating Parkin-mediated mitophagy, en route to preserved mitochondrial homeostasis and suppressed cardiomyocyte apoptosis...
August 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27731402/melatonin-improves-age-induced-fertility-decline-and-attenuates-ovarian-mitochondrial-oxidative-stress-in-mice
#14
Chao Song, Wei Peng, Songna Yin, Jiamin Zhao, Beibei Fu, Jingcheng Zhang, Tingchao Mao, Haibo Wu, Yong Zhang
Increasing evidence shows that melatonin protected against age-related mitochondrial oxidative damage. However, the protective effects of melatonin against ovarian aging has not been explored. Young Kunming females (aged 2-3 months) were fed with melatonin added to drinking water for 6 or 12 months (mo). We found that long-term (12 mo) melatonin treatment significantly reduced ovarian aging, as indicated by substantial increases in litter size, pool of follicles, and telomere length as well as oocyte quantity and quality...
October 12, 2016: Scientific Reports
https://www.readbyqxmd.com/read/26666995/liraglutide-ameliorates-non-alcoholic-fatty-liver-disease-by-enhancing-mitochondrial-architecture-and-promoting-autophagy-through-the-sirt1-sirt3-foxo3a-pathway
#15
Wenxin Tong, Liping Ju, Miaoyan Qiu, Qihai Xie, Ying Chen, Weili Shen, Weihong Sun, Weiqing Wang, Jingyan Tian
AIM: Overwhelming oxidative stress is implicated as crucial in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Liraglutide, a well-established antidiabetes drug, was recently reported to ameliorate NAFLD with an elusive mechanism. We used a mouse model to examine whether liraglutide could ameliorate NAFLD and explored the possible mechanisms. METHODS: Twenty C57BL/6J mice were randomly treated with a normal-fat diet or high-fat diet for 16 weeks, then further distributed into four groups and subjected to s...
August 2016: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/26523980/sirtuin-3-regulates-foxo3a-mediated-antioxidant-pathway-in-microglia
#16
P Rangarajan, A Karthikeyan, J Lu, E-A Ling, S T Dheen
Microglia are the prime cellular sources of reactive oxygen species (ROS) in the central nervous system (CNS). Chronic activation of microglia has been linked to aging-associated neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD) since they produce excessive amounts of ROS for a prolonged duration leading to oxidative stress. The present study was aimed at investigating the expression and role of Sirtuin 3 (Sirt3), a protein deacetylase which is implicated in regulating cellular ROS levels...
December 17, 2015: Neuroscience
https://www.readbyqxmd.com/read/26058697/sirtuin-3-mediates-neuroprotection-of-ketones-against-ischemic-stroke
#17
Junxiang Yin, Pengcheng Han, Zhiwei Tang, Qingwei Liu, Jiong Shi
Stroke is one of the leading causes of death. Growing evidence indicates that ketone bodies have beneficial effects in treating stroke, but their underlying mechanism remains unclear. Our previous study showed ketone bodies reduced reactive oxygen species by using NADH as an electron donor, thus increasing the NAD(+)/NADH ratio. In this study, we investigated whether mitochondrial NAD(+)-dependent Sirtuin 3 (SIRT3) could mediate the neuroprotective effects of ketone bodies after ischemic stroke. We injected mice with either normal saline or ketones (beta-hydroxybutyrate and acetoacetate) at 30 minutes after ischemia induced by transient middle cerebral artery (MCA) occlusion...
November 2015: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/26005404/differential-expression-of-sirtuins-in-the-aging-rat-brain
#18
Nady Braidy, Anne Poljak, Ross Grant, Tharusha Jayasena, Hussein Mansour, Tailoi Chan-Ling, George Smythe, Perminder Sachdev, Gilles J Guillemin
Although there are seven mammalian sirtuins (SIRT1-7), little is known about their expression in the aging brain. To characterize the change(s) in mRNA and protein expression of SIRT1-7 and their associated proteins in the brain of "physiologically" aged Wistar rats. We tested mRNA and protein expression levels of rat SIRT1-7, and the levels of associated proteins in the brain using RT-PCR and western blotting. Our data shows that SIRT1 expression increases with age, concurrently with increased acetylated p53 levels in all brain regions investigated...
2015: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/25979314/arsenic-induces-insulin-resistance-in-mouse-adipocytes-and-myotubes-via-oxidative-stress-regulated-mitochondrial-sirt3-foxo3a-signaling-pathway
#19
Sasidharan Padmaja Divya, Poyil Pratheeshkumar, Young-Ok Son, Ram Vinod Roy, John Andrew Hitron, Donghern Kim, Jin Dai, Lei Wang, Padmaja Asha, Bin Huang, Mei Xu, Jia Luo, Zhuo Zhang
Chronic exposure to arsenic via drinking water is associated with an increased risk for development of type 2 diabetes mellitus (T2DM). This study investigates the role of mitochondrial oxidative stress protein Sirtuin 3 (Sirt3) and its targeting proteins in chronic arsenic-induced T2DM in mouse adipocytes and myotubes. The results show that chronic arsenic exposure significantly decreased insulin-stimulated glucose uptake (ISGU) in correlation with reduced expression of insulin-regulated glucose transporter type 4 (Glut4)...
August 2015: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/25855962/oroxylin-a-inhibits-glycolysis-dependent-proliferation-of-human-breast-cancer-via-promoting-sirt3-mediated-sod2-transcription-and-hif1%C3%AE-destabilization
#20
L Wei, Y Zhou, C Qiao, T Ni, Z Li, Q You, Q Guo, N Lu
Alterations of cellular metabolism play a central role in the development and progression of cancer. Oroxylin A, an active flavonoid of a Chinese traditional medicinal plant, was previously shown to modulate glycolysis in cancer cells. However, the mechanism by which oroxylin A regulates glycolysis is still not well defined. Here, we show that oroxylin A inhibits glycolysis in breast cancer cells via the Sirtuin 3 (SIRT3)-mediated destabilization of hypoxia-inducible factor 1α (HIF1α), which controls glycolytic gene expression...
2015: Cell Death & Disease
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