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https://www.readbyqxmd.com/read/28053286/increased-autophagy-in-fibroblast-like-synoviocytes-leads-to-immune-enhancement-potential-in-rheumatoid-arthritis
#1
Ru Yang, Yingzi Zhang, Lin Wang, Ji Hu, Jian Wen, Leixi Xue, Mei Tang, Zhichun Liu, Jinxiang Fu
The incidence of rheumatoid arthritis (RA) has been reported to be correlated with a disorder of immunregulation. Rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs) play an important role in regulating the local immune microenvironment. However, the potential mechanism of RA-FLS in regulating the immnue response is not clearly understood. In this study, we demonstrated that the expression of HIF-1α was significantly up-regulated in rheumatoid arthritis tissue which indicated that the hypoxia condition in the microenvironment...
February 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/26642654/methotrexate-and-myotrexate-induce-apoptosis-in-human-myoma-fibroblasts-t-hes-cell-line-via-mitochondrial-pathway
#2
Tatjana Kastratović, Slobodan Arsenijević, Zoran Matović, Marina Mitrović, Ivana Nikolić, Zoran Milosavljević, Zoran Protrka, Marija Šorak, Janko Đurić
Uterine leiomyomas (fibroids) are the most common benign tumors in women of reproductive age. Although the local application of low doses of methotrexate (MTX) is used as an effective treatment of the myomas, myotrexate could be a promising new drug. This study investigated the cytotoxic and apoptotic effects of both MTX and myotrexate in human fibroblasts derived from the uterine fibroids (T hES cell line). The myotrexate adduct is an aqueous solution of MTX and L-arginine. Cells were treated with a graded concentrations of both MTX and myothrexate (0...
May 2015: Acta Poloniae Pharmaceutica
https://www.readbyqxmd.com/read/25854343/tumor-derived-cd4-cd25-tregs-inhibit-the-maturation-and-antigen-presenting-function-of-dendritic-cells
#3
Yong Du, Xin Chen, Xiu-Qing Lin, Wei Wu, Zhi-Ming Huang
CD4+CD25+regulatory T cells (Tregs) play a key role in regulation of immnue response and maintenance of self-tolerance. Studies have found Tregs could suppress tumor-specific T cell-mediated immune response and promote cancer progression. Depletion of Tregs can enhance antitumor immunity. Dendritic cells (DCs) are professional antigen-presenting cells and capable of activating antigen-specific immune responses, which make them ideal candidate for cancer immunotherapy. Now various DC vaccines are considered as effective treatment for cancers...
2015: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/21856086/atrial-natriuretic-peptide-natriuretic-peptide-receptor-a-anp-npra-signaling-pathway-a-potential-therapeutic-target-for-allergic-asthma
#4
Libing Ma, Xudong Xiang
Allergic asthma is a chronic inflammatory disease of airway and immune disorder is an acknowledged mechanism. Numerous data demonstrate Th1/Th2 cells play an important role in the development of allergic asthma. Atrial natriuretic peptide (ANP) is a multifunctional hormone secreted by cardiac atria, lung, and so forth, which has been recognized for several decades due to its general effects on cardiovascular system, and natriuretic peptide receptor A (NPRA) is the major effecting receptor for ANP. In recent years, more and more studies suggest that ANP/NPRA signaling pathway is implicated in modulation of immnue and inflammatory reaction...
November 2011: Medical Hypotheses
https://www.readbyqxmd.com/read/19213341/-curative-effect-of-integrative-medical-therapy-for-systematic-lupus-erythematosus
#5
RANDOMIZED CONTROLLED TRIAL
Shu-Zhen Liu, Guang-Xi Liu, San-Yun Liu
OBJECTIVE: To observe the curative effect of integrative medicine for treatment of systematic lupu erythematosus (SLE). METHODS: Totally 110 cases of SLE were randomized into two groups, 50 in the control group and 60 in the treated group, both were treated with prednisone, but to the treated group, integrative medica treatment was given additionally according to syndrome differentiation. The course for both groups was 6 months. Clinical symptoms, immunological indexes, peripheral blood figure, erythrocyte sedimentation rate (ESR), levels of C-reactive protein (CRP) and creatinine (Cr) in blood, and 24 h urinary total protein (u-TP/24 h) were observed before and after treatment...
November 2008: Chinese Journal of Integrated Traditional and Western Medicine
https://www.readbyqxmd.com/read/19034913/micrornas-novel-regulators-during-the-immune-response
#6
REVIEW
Yujing Bi, Guangwei Liu, Ruifu Yang
MicroRNAs (miRNAs), an abundant class of highly conversed, small noncoding RNAs, present an entirely new way of post-transcriptional gene regulation. miRNAs play a key role in diverse biological processes, such as embryogenesis, differentiation, inflammation, viral infections, and carcinogenesis. Recently, more studies showed the importance of these noncoding small RNAs on immune system development and response, and miRNAs are found to involve in the regulation of immunity, including the development and differentiation of immnue cells, antibody production and the inflammatory mediator release...
March 2009: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/140699/the-release-of-beta-glucuronidase-from-leukocytes-in-the-presence-of-immune-complexes
#7
B Watson, R W Gange, E L Rhodes, A E Rosling
The lysosomal enzyme beta glucuronidase was selectively released from leukocytes when these were incubated with insoluble immnue complexes and also from the leukocytes of patients with immune complex disease when these were incubated with their own plasma.
April 1977: British Journal of Dermatology
https://www.readbyqxmd.com/read/67090/characterization-of-the-in-vitro-cytotoxic-assay-of-immune-lymphoid-cells-in-experimental-allergic-encephalomyelitis-eae
#8
A R Allbritton, R W Loan
Complement, antilymphocyte globulin, antiencephalitogenic antigen serum, actinomycin D and mitomycin C inhibited the cytotoxicty against syngenic fibroblasts of spleen cells more than lymph node cells. The results strongly suggest that the immune cell populations in EAE in the spleen andlymph nodes are qualitatively and/or quantitatively different. Cytotoxicity was dependent upon the number of immnue cells in the test. There was evidence of antigenic competition between encephalitogenic antigen and Myocobacterium tuberculosis in the induction of EAE...
1977: International Archives of Allergy and Applied Immunology
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